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However, the CEnNS process generates signals at the few keV level, requiring very sensitive detection technologies. The European Spallation Source (ESS) has been identified as an optimal source of low energy neutrinos offering an opportunity to explore at depth the physics of CEnNS, with large discovery potential. In this project, I propose to apply the high-pressure noble gas TPC technology to the detection of the CEnNS process at the ESS. This will require the detection techniques sensitive to very low-energy depositions as well as improving the current knowledge of the quenching factor for nuclear recoils in xenon, argon and neon gas at keV energies. This project proposes the development of a novel detector able to hold 20 kg of xenon gas at high pressure. The device will operate at the ESS, providing more than 7,000 CEnNS events per year, potentially overtaking the sensitivities of much larger detectors in current spallation sources. Operation with xenon will explore most of the possible new physics associated with the CEnNS process. 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Regarding gearing technology, there is a long-standing challenge to get the maximum gear range (large variation between the easiest and hardest gears in order to access a wider set of terrains) with minimum steps between gears (for improved efficiency on each terrain). However, little changes have been observed in bicycle transmissions in the last 60 years. Even the recent introduction of electronic derailleurs did not meet market expectations regarding the possibility of achieving sequential or automatic shifting. SEGSEQ presents a segmented chainring actuation system that provides smooth and reliable shifting in any situation. The disruptive technological proposal of SEGSEQ introduces several characteristics that cannot be found currently in any product of a market very much monopolized by 2 companies (Shimano and Sram). The system provides performance gains in all metrics: 30% more usable gears, 15% wider gear-range, 15% closer gear-steps, 6% less weight and the possibility to operate shifts in sequential form and even in automatic form using cadence, pedalling power and\/or heart-rate feedback.\nAfter multiple iterations and refinements of the SEGSEQ concept, application for several patents and the favorable timing for using complementary solutions whose patent protection expires in 2019-2020, the aim of the present project is to enter the 2,400 M\u20ac groupset market and become the leading technological reference. Due to the strong competitors, it is daring for conventional investors to finance a promising concept that has not been thoroughly tested by the market. However, it is believed that the disruptive nature of SEGSEQ has the potential to become the European contender to lead the groupset market. In this context, ZUMA is looking for 1.7 M\u20ac for product development (1.2 M\u20ac EIC grant + 0.5 M\u20ac via other sources) and 3.5 M\u20ac for market deployment (via EIC equity).","language":"en"}],"award-amount":{"amount":1217475.0,"currency":"EUR"},"award-start":{"date-parts":[[2020,9,1]]},"funding":[{"type":"grant","scheme":"H2020-EU.2.3.","award-amount":{"amount":1217475.0,"currency":"EUR","percentage":100},"funder":{"id":[{"id":"10.13039\/100010675","id-type":"DOI","asserted-by":"publisher"}],"name":"H2020 Innovation In SMEs"}}]}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T07:46:54Z","timestamp":1738050414000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/cordis.europa.eu\/project\/id\/953550"}},"issued":{"date-parts":[[2020,9,1]]},"URL":"https:\/\/doi.org\/10.3030\/953550"},{"indexed":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T13:40:11Z","timestamp":1690206011813},"publisher":"Publications Office of the European Union","award-start":{"date-parts":[[2022,11,3]]},"award":"101031112","DOI":"10.3030\/101031112","type":"grant","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T15:09:28Z","timestamp":1670857768000},"source":"Crossref","prefix":"10.3030","member":"4854","project":[{"project-title":[{"title":"Uncovering the mechanisms of osteoarthritis in human knee applying spatial transcriptomics","language":"en"},{"title":"SpatialArth","language":"en"}],"project-description":[{"description":"Osteoarthritis (OA) is the most prevalent chronic musculoskeletal disorder causing pain, morbidity and disability, giving rise to enormous healthcare expenditures and loss of work. The exact triggers and pathogenesis of OA are still poorly understood. Currently, there are no measures to slow down the progression of OA. Bulk tissue-based multi-omics and small-scale single cell RNA-seq studies focussing on chondrocytes and synoviocytes have identified novel cell clusters, supporting the hypothesis that OA is a disease of the whole joint. However, one of the key relevant tissues (bone) have not yet been studied. In addition, approaches to date have employed lengthy live cell extraction approaches that affect the transcriptome pattern. Finally, the spatial dimension of molecular changes in the osteochondral unit has not been studied to date. This work will fill this fundamental gap in our understanding of the molecular aetiopathogenesis and progression of OA by employing a novel cutting-edge technique, spatial transcriptomics (ST). 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If miR-124 disruption causes aberrant activity of epigenetic modifiers including NRSF then we will test whether miR-124 restitution can restore correct gene expression networks and prevent or modify epileptogenesis in a mouse model of the disorder. Next we will determine whether data obtained in mouse models is translatable to the human form of the condition by obtaining and maintaining resected human epileptic hippocampus live in culture. We will ectopically introduce miR-124 and test the effect of miR-124 restitution on network activity and energetics using live-calcium imaging as well as the epigenomic and transcriptomic effects. Together this proposal represents the most in-depth analysis of miRNA function and will set the standard for future functional analyses of these molecules. 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Malaria parasites are also responsible for wildlife population declines and even extinction of many bird species. Despite being exposed to the same risk, there is a clear inter-individual variation in the susceptibility to malaria infection. Through MATHORMAL, I propose that such inter-individual variability in malaria susceptibility might be linked to both the prenatal programming of physiology by maternal hormonal effects and by initial differences in cellular ageing (i.e. assessed through telomere length). Higher exposure to certain maternal hormones can depress immunity, accelerate cellular ageing, and deregulate the protective microbiome of the uropygial gland linked to antimalarial defensive mechanisms. Thus, I hypothesize that increased prenatal exposure to certain maternal hormones could make the offspring more susceptible to malarial infections, potentially through its effects on telomeres and uropygial microbiome. 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MATHORMAL will use an integrative approach at the crossroad of evolutionary ecology, ecophysiology, and parasitology and largely benefit from the dual knowledge transfer between myself (expertise in maternal hormonal effects and avian malaria) and my host group (expertise in maternal hormonal effects and telomere biology).","language":"en"}],"award-amount":{"amount":215534.4,"currency":"EUR"},"award-start":{"date-parts":[[2023,9,1]]},"funding":[{"type":"grant","scheme":"HORIZON.1.2","award-amount":{"amount":215534.4,"currency":"EUR","percentage":100},"funder":{"id":[{"id":"10.13039\/100018694","id-type":"DOI","asserted-by":"publisher"}],"name":"HORIZON EUROPE HORIZON.1.2"}}]}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T13:42:29Z","timestamp":1741700549000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/cordis.europa.eu\/project\/id\/101063149"}},"issued":{"date-parts":[[2023,9,1]]},"URL":"https:\/\/doi.org\/10.3030\/101063149"},{"indexed":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:36:35Z","timestamp":1741754195349,"version":"3.38.0"},"publisher":"Publications Office of the European Union","award-start":{"date-parts":[[2022,4,1]]},"award":"190117010","DOI":"10.3030\/190117010","type":"grant","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T15:24:02Z","timestamp":1670858642000},"source":"Crossref","prefix":"10.3030","member":"4854","project":[{"project-title":[{"title":"Ubiquitous in-line mass spectroscopy for industrial process monitoring and optimization with sustainable impacts","language":"en"},{"title":"UBISpec","language":"en"}],"project-description":[{"description":"Spectro Inlets aims to commercialise the first mass-spectrometer (MS) to be used as an integral part of chemical-process based industries. 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As core novelty, the CO will be produced in situ apart from the electrode in the bulk solution from CO2 through a mediated electron transfer to free floating beads where CO-dehydrogenase is immobilized within the acetate forming bacterial cell culture. This will enable for the first time, full compatibility between electrochemical and biocatalytic processes. The synthetic aim is to yield high value-added diamine monomers as building blocks for established classes of polymeric materials. ECOMO will establish new bio based and biohybrid modules that will be directly compatible with the existing bioreactor infrastructure for the producing of specialty chemicals directly from CO2. By achieving the production of diamines as a proof-of-concept, ECOMO will foster further diversification to many other products made from CO2 and thus enhances the synthetic availability of needed building blocks for the chemical industry. 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At a critical regulatory intersection of translation and folding, ribosomes act as integration hubs coordinating chaperone, enzyme and membrane targeting factor activity, influencing folding. Final assembly of proteins into oligomeric complexes however, has long been considered post-translational and dependent on random collision of fully synthesized diffusing subunits. In a shift of paradigm, recent evidence from the Bukau laboratory now suggests that in bacteria, assembly initiates co-translationally assisted by chaperones, and gene organization into operons drives co-localized translation of complex subunits that impacts efficiency of assembly. Fundamental differences in eukaryotes such as rarity of operons and differing chaperone constellations imply a widely different folding and assembly biology, which remains largely unexplored. The selective ribosome profiling (SeRP) method, developed by the Bukau lab, now allows ground breaking identification and definition of dynamic interactions of nascent chains, at near-residue resolution. Using SeRP with supporting biochemistry, I will unravel the nascent chain molecular biology underpinning protein folding and assembly in yeast, Saccharomyces cerevisiae, a powerful model for studying the fundamental aspects of this biology. Specifically, I will establish (1) basic features and prevalence of co-translational protein assembly, (2) how chaperones guide co-translational protein folding to affect assembly. Subunit interaction profiles complemented by chaperone interaction profiles, will expose the timing and interplay of protein folding and assembly steps linked to protein synthesis, establishing a detailed conceptually new biology of complex assembly in eukaryotes.","language":"en"}],"award-amount":{"amount":171460.8,"currency":"EUR"},"award-start":{"date-parts":[[2018,5,1]]},"funding":[{"type":"grant","scheme":"MSCA-IF-2016","award-amount":{"amount":171460.8,"currency":"EUR","percentage":100},"funder":{"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}],"name":"H2020 Marie Sk?odowska-Curie Actions"}}]}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T13:39:20Z","timestamp":1715693960000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/cordis.europa.eu\/project\/id\/753530"}},"issued":{"date-parts":[[2018,5,1]]},"URL":"https:\/\/doi.org\/10.3030\/753530"},{"indexed":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:51:34Z","timestamp":1710377494903},"publisher":"Austrian Science Fund (FWF)","award":"PAT2965423","DOI":"10.55776\/pat2965423","type":"grant","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T17:11:11Z","timestamp":1710349871000},"source":"Crossref","prefix":"10.55776","member":"34446","project":[{"project-title":[{"title":"Phosphate modifications in lipid A with glycochemistry tools"}],"funding":[{"type":"grant","award-amount":{"amount":484182.97,"currency":"EUR","percentage":100},"funder":{"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}],"name":"Austrian Science Fund (FWF)"}}]}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T17:11:29Z","timestamp":1710349889000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/www.fwf.ac.at\/en\/research-radar\/10.55776\/PAT2965423"}},"issued":{"date-parts":[[null]]},"URL":"https:\/\/doi.org\/10.55776\/pat2965423"},{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T02:59:59Z","timestamp":1649127599693},"publisher":"Japan Science and Technology Agency (JST)","award":"JPMJPR2093","DOI":"10.52926\/jpmjpr2093","type":"grant","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T08:05:13Z","timestamp":1643961913000},"source":"Crossref","prefix":"10.52926","member":"272","project":[{"project-title":[{"title":"\u5468\u671f\u30df\u30af\u30ed\u5f37\u5ea6\u52fe\u914d\u5236\u5fa1\u306b\u3088\u308b\u591a\u6a5f\u80fd\u6750\u6599\u8a2d\u8a08","language":"ja"}],"project-description":[{"description":"\u672c\u7814\u7a76\u3067\u306f\u3001\u69cb\u9020\u7528\u91d1\u5c5e\u6750\u6599\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u300c\u30ca\u30ce\u30b9\u30b1\u30fc\u30eb\u3067\u7d44\u7e54\u5236\u5fa1\u3057\u3066\u30df\u30ea\u30b9\u30b1\u30fc\u30eb\u3067\u6a5f\u80fd\u767a\u73fe\u300d\u3055\u305b\u308b\u6307\u91dd\u3092\u660e\u78ba\u5316\u3057\u307e\u3059\u3002\u5468\u671f\u69cb\u9020\u5185\u306e\u5168\u7d44\u7e54\u306b\u5bfe\u3059\u308b\u9023\u7d9a\u640d\u50b7\u8a08\u6e2c\u304a\u3088\u3073\u529b\u5b66\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u884c\u3044\u3001\u52d5\u7684\u8a66\u9a13\u306b\u304a\u3051\u308b\u30df\u30af\u30ed\u306a\u8ee2\u4f4d\u306e\u767a\u751f\u30fb\u904b\u52d5\u3068\u3001\u30de\u30af\u30ed\u306a\u5909\u5f62\u306e\u975e\u7dda\u5f62\u6027\u306e\u91cd\u7573\u52b9\u679c\u3092\u89e3\u660e\u3057\u307e\u3059\u3002\u9ad8\u5f37\u5ea6\u76f8\u304c\u4f4e\u5f37\u5ea6\u76f8\u3092\u5305\u307f\u8fbc\u3093\u3060\u5468\u671f\u69cb\u9020\u5236\u5fa1\u6750\u6599\u306b\u304a\u3051\u308b\u3001\u7279\u7570\u306a\u52d5\u7684\u640d\u50b7\u767a\u751f\u30fb\u9032\u884c\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3059\u3002","language":"ja"}],"lead-investigator":[{"given":"\u5c06\u4e00","family":"\u83ca\u6c60","affiliation":[{"name":"\u9759\u5ca1\u5927\u5b66, \u5de5\u5b66\u90e8"}]}],"award-start":{"date-parts":[[2020,4,1]]},"award-end":{"date-parts":[[2024,3,31]]},"funding":[{"type":"grant","scheme":"\u6226\u7565\u7684\u306a\u7814\u7a76\u958b\u767a\u306e\u63a8\u9032\/\u6226\u7565\u7684\u5275\u9020\u7814\u7a76\u63a8\u9032\u4e8b\u696d\/\u3055\u304d\u304c\u3051 \u529b\u5b66\u6a5f\u80fd\u306e\u30ca\u30ce\u30a8\u30f3\u30b8\u30cb\u30a2\u30ea\u30f3\u30b0","funder":{"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}],"name":"Japan Science and Technology Agency"}}]}],"deposited":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T08:06:30Z","timestamp":1643961990000},"score":0.0,"resource":{"primary":{"URL":"https:\/\/projectdb.jst.go.jp\/grant\/JST-PROJECT-20343899\/"}},"issued":{"date-parts":[[2020,4,1]]},"URL":"https:\/\/doi.org\/10.52926\/jpmjpr2093"}],"items-per-page":20,"query":{"start-index":0,"search-terms":null}}}