{"status":"ok","message-type":"work-list","message-version":"1.0.0","message":{"facets":{},"total-results":772017,"items":[{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:41:37Z","timestamp":1753890097479,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"In men with obesity and IGT, serum testosterone (T) is inversely associated with incident T2D. Hypothesizing that T treatment prevents or reverses T2D beyond the effects of a lifestyle program alone, we conducted a multi-center, double-blinded placebo-controlled trial. Men (N=1007), aged 50-74 yrs., waist circumference (WC)&gt;95cm, serum T\u226414nmol\/L (chemiluminescent assay), and IGT or newly diagnosed T2D, established by an OGTT, were randomized to receive, on a 1:1 basis, either IM T undecanoate (Reandron, Bayer) (1000mg\/4ml) or vehicle (V) at baseline, 6 weeks and then 3-monthly for 2 yrs. All participants were enrolled in a lifestyle program (Weight Watchers\u00ae (WW)). Co-primary 2-yr outcomes: (1) OGTT 2-hr glucose \u226511 mmol\/L: 55\/443 (12.4%) in the T and 87\/413 (21.1%) in V groups; RR (95% CI) 0.59 (0.43-0.80), P&lt;0.001; and (2) mean change from baseline in 2-hr glucose: -1.70 mmol\/L and -0.95 mmol\/L in the T and V groups, respectively (mean difference -0.75 (95% CI -1.10 to -0.40) P&lt;0.001). The treatment effect was independent of baseline serum T. Secondary 2-year outcomes: Greater decreases from baseline in fasting glucose by 0.17 mmol\/L, WC by 2.1 cm, total fat mass by 2.7kg, and abdominal fat mass by 2.3%, and greater increases in total muscle mass by 1.7kg, arm muscle mass by 0.36kg and hand grip strength by 2.2kg, occurred in the T vs. V group (all P&lt;0.004). Compliance with the WW program was similar in the T (30%) vs. V (28%) groups (P=0.89). Safety: Hematocrit \u2265 0.54: 106\/491 (21.6%) vs. 6\/484 (1.2%) in the T vs. V groups (P&lt;0.001). SAEs in T vs. V groups (total events 55 vs. 42): Arrythmias (8 vs. 3), IHD (7 vs. 13), cerebrovascular disease (4 vs. 3), BPH (8 vs. 3), prostate cancer (4 vs. 5), other cancers (10 vs. 4), depression (1 vs. 3). There were 2 deaths in each group. Beyond a lifestyle program, T treatment reduced the RR of T2D by \u223c40% at least partially mediated by favorable changes in body composition. Clinical Trial Registration: ACTRN12612000287831.<\/jats:p>\n \n Disclosure<\/jats:title>\n G.A. Wittert: Research Support; Self; Bayer Inc., Lawley Pharmaceuticals, Lilly, Weight Watchers International, Inc. Speaker\u2019s Bureau; Self; Besins. K.P. Robledo: None. M. Grossmann: Research Support; Self; Bayer Healthcare Pharmaceuticals Inc., Lilly Diabetes, Novartis Pharmaceuticals Canada Inc., Otsuka Pharmaceutical Co., Ltd., Weight Watchers International, Inc. Speaker\u2019s Bureau; Self; Besins Healthcare, Otsuka Pharmaceutical Co., Ltd. K. Bracken: None. B.B. Yeap: Advisory Panel; Self; Sanofi. Research Support; Self; Bayer AG, Lawley Pharmaceuticals. Speaker\u2019s Bureau; Self; Besins, Sanofi. B.G.A. Stuckey: None. R.I. McLachlan: None. D.J. Handelsman: None. C. Allan: Advisory Panel; Self; Ferring Pharmaceuticals. Speaker\u2019s Bureau; Self; Besins. W. Inder: Research Support; Self; Bayer Healthcare Pharmaceuticals Inc. Speaker\u2019s Bureau; Self; Amgen, Novo Nordisk Inc., Pfizer Inc. D. Jesudason: Other Relationship; Self; Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company. A.C. Keech: Advisory Panel; Self; Amgen, Kowa Research Institute, Inc. Consultant; Self; Sanofi-Aventis. Speaker\u2019s Bureau; Self; Abbott, Amgen. A. Jenkins: Advisory Panel; Self; Abbott, Medtronic. Research Support; Self; Abbott, GlySens Incorporated, Medtronic, Sanofi-Aventis. M. Ng Tang Fui: None. M. Daniel: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Health and Medical Council of Australia (1030123); Eli Lilly and Company; Bayer AG; Weight Watchers; University of Adelaide<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-274-or","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:49Z","timestamp":1592238589000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":4,"title":["274-OR: Effect of Testosterone Treatment on Type 2 Diabetes Incidence in High-Risk Men Enrolled in a Lifestyle Program: A Two-Year Randomized Placebo-Controlled Trial"],"prefix":"10.2337","volume":"69","author":[{"given":"GARY A.","family":"WITTERT","sequence":"first","affiliation":[{"name":"Adelaide, Australia, Heidelberg West, Australia, Perth, Australia, Nedlands, Australia, Sydney, Australia, Clayton, Australia, Brisbane, Australia, Woodville South, Australia, Bruce, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KRISTY P.","family":"ROBLEDO","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Heidelberg West, Australia, Perth, Australia, Nedlands, Australia, Sydney, Australia, Clayton, Australia, Brisbane, Australia, Woodville South, Australia, Bruce, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MATHIS","family":"GROSSMANN","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Heidelberg West, Australia, Perth, Australia, Nedlands, Australia, Sydney, Australia, Clayton, Australia, Brisbane, Australia, Woodville South, Australia, Bruce, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAREN","family":"BRACKEN","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Heidelberg West, Australia, Perth, Australia, Nedlands, Australia, Sydney, Australia, Clayton, Australia, Brisbane, Australia, Woodville South, Australia, Bruce, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BU B.","family":"YEAP","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Heidelberg West, Australia, Perth, Australia, Nedlands, Australia, Sydney, Australia, Clayton, Australia, Brisbane, Australia, Woodville South, Australia, Bruce, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRONWYN G.A.","family":"STUCKEY","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Heidelberg West, Australia, Perth, Australia, Nedlands, Australia, Sydney, Australia, Clayton, Australia, Brisbane, Australia, Woodville South, Australia, Bruce, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERT I.","family":"MCLACHLAN","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Heidelberg West, Australia, Perth, Australia, Nedlands, Australia, Sydney, Australia, Clayton, Australia, Brisbane, Australia, Woodville South, Australia, Bruce, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID J.","family":"HANDELSMAN","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Heidelberg West, Australia, Perth, Australia, Nedlands, Australia, Sydney, Australia, Clayton, Australia, Brisbane, Australia, Woodville South, Australia, Bruce, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CAROLYN","family":"ALLAN","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Heidelberg West, Australia, Perth, Australia, Nedlands, Australia, Sydney, Australia, Clayton, Australia, Brisbane, Australia, Woodville South, Australia, Bruce, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WARRICK","family":"INDER","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Heidelberg West, Australia, Perth, Australia, Nedlands, Australia, Sydney, Australia, Clayton, Australia, Brisbane, Australia, Woodville South, Australia, Bruce, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"JESUDASON","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Heidelberg West, Australia, Perth, Australia, Nedlands, Australia, Sydney, Australia, Clayton, Australia, Brisbane, Australia, Woodville South, Australia, Bruce, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTHONY C.","family":"KEECH","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Heidelberg West, Australia, Perth, Australia, Nedlands, Australia, Sydney, Australia, Clayton, Australia, Brisbane, Australia, Woodville South, Australia, Bruce, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Heidelberg West, Australia, Perth, Australia, Nedlands, Australia, Sydney, Australia, Clayton, Australia, Brisbane, Australia, Woodville South, Australia, Bruce, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK NG","family":"TANG FUI","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Heidelberg West, Australia, Perth, Australia, Nedlands, Australia, Sydney, Australia, Clayton, Australia, Brisbane, Australia, Woodville South, Australia, Bruce, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK","family":"DANIEL","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Heidelberg West, Australia, Perth, Australia, Nedlands, Australia, Sydney, Australia, Clayton, Australia, Brisbane, Australia, Woodville South, Australia, Bruce, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/274-OR\/56877\/274-OR-Effect-of-Testosterone-Treatment-on-Type-2","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/274-OR\/56877\/274-OR-Effect-of-Testosterone-Treatment-on-Type-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:51:12Z","timestamp":1647165072000},"score":7.885387,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/274-OR\/56877\/274-OR-Effect-of-Testosterone-Treatment-on-Type-2"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-274-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"274-OR"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:11Z","timestamp":1753889831037,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"We aimed to characterise the gut microbiome and small intestinal permeability in children with islet autoimmunity and type 1 diabetes (T1D). 88 participants, median age 11.8 (IQR 8.1-13.3) years at baseline were followed 6 monthly for a median of 13 months (range 2-34). 18 had islet autoimmunity, 29 recent-onset T1D, and 41 were age and gender-matched unrelated or sibling controls. Stool samples were collected (Omnigene kit) for 16S rRNA gene sequencing. Small intestinal permeability was measured by blood lactulose:rhamnose ratio (L\/R), 90 minutes after drinking a 5gm lactulose\/1gm rhamnose solution. Antibodies to insulin, GAD, IA2 and ZnT8 were assayed using IASP standardized radiobinding assays. Statistical analysis used linear mixed models. Differential abundance analysis used limma with total-sum scaling.<\/jats:p>\n Children with islet autoimmunity or T1D had gut microbiome dysbiosis with reduced \u03b1 diversity and different \u03b2 diversity compared with controls. Progressors from islet autoimmunity to T1D had lower observed richness (OTUs) (p=0.01) and different \u03b2 diversity (Adonis, P=0.004), compared with non-progressors. Genus Prevotella, with anti-inflammatory properties, was less abundant in children with T1D (p&lt;0.005) or \u2265 2 islet antibodies (p&lt;0.005) than in controls. Diet did not explain this difference. L\/R was higher in T1D than sibling controls (mean difference +3.03\u00b11.02, p=0.003). Progressors had higher L\/R than non-progressors (+4.74\u00b11.97, p=0.01) and sibling controls (+4.62\u00b11.69, p=0.006). There was a trend towards a relationship between higher L\/R and lower observed richness in the microbiome over time in children with \u2265 2 islet antibodies or T1D (coeff -0.0617, 95% CI -0.1254, 0.002 P=0.058).<\/jats:p>\n Australian children progressing from islet autoimmunity to T1D have gut dysbiosis and increased intestinal permeability. This observation supports a mechanism underlying progression to T1D.<\/jats:p>\n \n Disclosure<\/jats:title>\n J.E. Harbison: None. A.J. Roth-Schulze: None. S.C. Barry: None. C.D. Tran: None. K. Ngui: None. M.A. Penno: None. J. Wentworth: None. P.G. Colman: None. R. Thomson: None. M.E. Craig: None. A.T. Papenfuss: None. L. Giles: None. L.C. Harrison: None. J. Couper: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-230-or","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:33Z","timestamp":1529693853000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":3,"title":["Gut Microbiome Dysbiosis and Increased Intestinal Permeability in Australian Children with Islet Autoimmunity and Type 1 Diabetes"],"prefix":"10.2337","volume":"67","author":[{"given":"JESSICA E.","family":"HARBISON","sequence":"first","affiliation":[{"name":"Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALEXANDRA J.","family":"ROTH-SCHULZE","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SIMON C.","family":"BARRY","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CUONG D.","family":"TRAN","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATRINA","family":"NGUI","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MEGAN A.","family":"PENNO","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN","family":"WENTWORTH","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER G.","family":"COLMAN","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"REBECCA","family":"THOMSON","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA E.","family":"CRAIG","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTHONY T.","family":"PAPENFUSS","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LYNNE","family":"GILES","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEONARD C.","family":"HARRISON","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENNY","family":"COUPER","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/230-OR\/59246\/Gut-Microbiome-Dysbiosis-and-Increased-Intestinal","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/230-OR\/59246\/Gut-Microbiome-Dysbiosis-and-Increased-Intestinal","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:07:21Z","timestamp":1647166041000},"score":7.8784556,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/230-OR\/59246\/Gut-Microbiome-Dysbiosis-and-Increased-Intestinal"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-230-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"230-OR"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:35:56Z","timestamp":1753889756066,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Aboriginal and Torres Strait Islander women have high rates of gestational diabetes (GDM). The Pregnancy And Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study is a prospective longitudinal cohort of women with type 2 diabetes (T2D), GDM or normoglycemia in pregnancy in the Northern Territory, Australia. In this analysis we report progression to prediabetes and T2D at 2.5 years [range 2.1, 3] postpartum in a subgroup of Aboriginal and Europid women with GDM and normoglycemia in pregnancy (n=337). Women with pre-existing T2D were excluded. Data were analysed using Fisher\u2019s exact tests. Among Aboriginal women with GDM we assessed predictions for progression using multivariate logistic regression. Aboriginal women with GDM (n=111) were younger than Europid women with GDM (n=104) (29 years (SD 5.9) vs. 32 (5.6) p&lt;0.01), with similar first trimester BMI (28.9 kg\/m2 (SD 7.2) vs. 28.5 (6.7) p=0.64). Of Aboriginal women with GDM, 24 (22%) progressed to T2D and 12 (11%) to prediabetes. Of Aboriginal women with normoglycemia (n=60), 1 (2%) progressed to T2D and 1 (2%) to prediabetes (p&lt;0.01 for combined outcome vs. GDM women). Of Europid women with GDM, none progressed to T2D and 4 (4%) to prediabetes and of those with normoglycemia (n=62) none progressed to diabetes or prediabetes (p=0.09 vs. GDM women). Among Aboriginal women with GDM, factors associated with postpartum diabetes or prediabetes were age (OR 1.11, 1.03-1.2) and, after adjusting for age: severity of GDM (higher fasting plasma glucose (per 1 mmol\/L OR 2.11, 1.23-3.62), use of insulin (OR 3.20, 1.35-7.6)) and higher first trimester BMI (per 3 kg\/m2 OR 1.22, 1.01-1.47). Not smoking was protective (OR 0.35, 0.14-0.90), although any breastfeeding at 6-months postpartum was not (OR 0.95, 0.36-2.47). To our knowledge this is the only prospective study of Aboriginal and Torres Strait Islander women with GDM. We report the highest rates in the world of T2D after GDM at 2.5 years postpartum, highlighting a need for targeted interventions in this high-risk population.<\/jats:p>\n \n Disclosure<\/jats:title>\n A. Wood: None. J. Boyle: None. F. Barzi: None. E.L. Barr: None. M.J.I. Hare: None. A. Titmuss: None. E. Death: None. M. Kirkwood: None. A. Simmonds: None. E.M. Moore: None. J. Oats: None. D. McIntyre: Other Relationship; Self; Novo Nordisk A\/S. P.Z. Zimmet: None. A.D. Brown: None. J.E. Shaw: Advisory Panel; Self; AstraZeneca, Merck Sharp & Dohme Corp., Mylan, Sanofi. Research Support; Self; AstraZeneca. Speaker\u2019s Bureau; Self; Eli Lilly and Company, Mylan. L.J. Maple-Brown: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-1365-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:48Z","timestamp":1592238588000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1365-P: Type 2 Diabetes after Gestational Diabetes, a High-Risk Population"],"prefix":"10.2337","volume":"69","author":[{"given":"ANNA","family":"WOOD","sequence":"first","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JACQUELINE","family":"BOYLE","sequence":"additional","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FEDERICA","family":"BARZI","sequence":"additional","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH L.","family":"BARR","sequence":"additional","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MATTHEW J.I.","family":"HARE","sequence":"additional","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANGELA","family":"TITMUSS","sequence":"additional","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH","family":"DEATH","sequence":"additional","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIE","family":"KIRKWOOD","sequence":"additional","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALISON","family":"SIMMONDS","sequence":"additional","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH M.","family":"MOORE","sequence":"additional","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEREMY","family":"OATS","sequence":"additional","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"MCINTYRE","sequence":"additional","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL Z.","family":"ZIMMET","sequence":"additional","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"ESQ.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALEX D.","family":"BROWN","sequence":"additional","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JONATHAN E.","family":"SHAW","sequence":"additional","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LOUISE J.","family":"MAPLE-BROWN","sequence":"additional","affiliation":[{"name":"Darwin, Australia, Nightcliff, Australia, Melbourne, Australia, Casuarina, Australia, Kincumber, Australia, Alice Springs, Australia, Carlton, Australia, South Brisbane, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1365-P\/61167\/1365-P-Type-2-Diabetes-after-Gestational-Diabetes","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1365-P\/61167\/1365-P-Type-2-Diabetes-after-Gestational-Diabetes","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:22:20Z","timestamp":1647166940000},"score":7.8657093,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1365-P\/61167\/1365-P-Type-2-Diabetes-after-Gestational-Diabetes"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-1365-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"1365-P"},{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:58:40Z","timestamp":1760623120460,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Background: Multiple regimens for the pharmacological management of diabetes exist. In Australia, new agents have become available in recent years. We examined temporal trends in prescribing patterns of pharmacotherapy regimens in Australia.<\/jats:p>\n Methods: The EXTEND45 Study links health information on consenting participants of the 45 and Up Study (2006-2009) with administrative health information from the Medicare Benefits Schedule (MBS) and Pharmaceutical Benefits Scheme (PBS) (provided by the Department of Human Services), community pathology providers and other routinely collected health information sources. Linkage was performed by the Centre for Health Record Linkage and the Sax Institute (MBS and PBS). We identified a population-based cohort (2006-2014) of people aged \u226545 years who met a pre-specified definition for diabetes. Treatment episodes amongst our cohort were identified, and defined as the period that a patient adhered to a particular regimen of pharmacotherapy without any changes or treatment breaks of two or more standard coverage days (SCD). Episodes were attributed to the calendar year in which they commenced and were categorized into six patterns of glucose lowering medication use.<\/jats:p>\n Results: We identified 24,236 participants with diabetes who experienced 149,532 treatment episodes over a mean follow-up period of 4.97 years. Episodes included: never treated (4.4%), monotherapy (33.1%), dual therapy (17.0%), triple or more therapy (4.0%), insulin-based therapy (21.7%) and treatment break (20.3%). Metformin (a biguanide) accounted for the majority (68.5%) of monotherapy episodes, followed by sulfonlyureas (23.1%). The combination of metformin and a sulfonylurea was the most common dual therapy episode (56.1%) but became less common over the study period (75.5% in 2006 to 41.1% in 2014).<\/jats:p>\n Conclusion: Most treatment episodes in our cohort involved a monotherapy regimen. There was a temporal change in the specific drug agents prescribed in dual therapy regimens, likely related to the availability of newer agents.<\/jats:p>\n \n Disclosure<\/jats:title>\n T.K. Young: None. C. Hockham: None. L. Sukkar: None. A. Kang: None. M. Jun: Research Support; Self; AstraZeneca. J. Baker: None. K. Rogers: None. A. Cass: None. C.A. Pollock: Advisory Panel; Self; AstraZeneca, Merck Sharp & Dohme Corp., Otsuka Pharmaceutical Co., Ltd., Vifor Pharma. Board Member; Self; Boehringer Ingelheim Pharmaceuticals, Inc. Speaker's Bureau; Self; Amgen Inc., AstraZeneca, Novartis AG, Vifor Pharma. Other Relationship; Self; Janssen Pharmaceuticals, Inc. D. Sullivan: None. G. Wong: None. M.J. Jardine: Advisory Panel; Self; Akebia Therapeutics, Baxter, Boehringer Ingelheim International GmbH, CSL Behring, Vifor Pharma. Research Support; Self; Amgen Inc., Baxter, Eli Lilly and Company, Gambro, Merck Sharp & Dohme Corp. Speaker's Bureau; Self; Janssen Pharmaceuticals, Inc. Other Relationship; Self; Janssen Pharmaceuticals, Inc.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Heart Foundation of Australia (100720); Roche Products Pty Ltd. (FR-MIR-0095); Rebecca L. Cooper Grant (REB002); Eli Lilly Australia Pty Ltd. (PO4100294024); Merck Sharp & Dohme Australia Pty Ltd. (MSD_EXTEND45); Amgen Australia Pty Ltd. (Amgen01)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-1130-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:36:43Z","timestamp":1559695003000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":4,"title":["1130-P: Temporal Trends in Pharmacotherapy for Diabetes"],"prefix":"10.2337","volume":"68","author":[{"given":"TAMARA K.","family":"YOUNG","sequence":"first","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARINNA","family":"HOCKHAM","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LOUISA","family":"SUKKAR","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AMY","family":"KANG","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIN","family":"JUN","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANNAH","family":"BAKER","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KRIS","family":"ROGERS","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALAN","family":"CASS","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CAROL A.","family":"POLLOCK","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"SULLIVAN","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GERMAINE","family":"WONG","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MEG J.","family":"JARDINE","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"EXTEND45 STUDY STEERING COMMITTEE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1130-P\/58641\/1130-P-Temporal-Trends-in-Pharmacotherapy-for","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1130-P\/58641\/1130-P-Temporal-Trends-in-Pharmacotherapy-for","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:59:17Z","timestamp":1647165557000},"score":7.863508,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1130-P\/58641\/1130-P-Temporal-Trends-in-Pharmacotherapy-for"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-1130-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"1130-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:33Z","timestamp":1753889793135,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2022,6,1]]},"abstract":"Background: Mitochondrial DNA (Mt-DNA) copy number (mtDNA-CN) has been proposed as a marker of diabetic kidney disease (DKD) . Most studies are in type 2 diabetes. We determined mtDNA-CN in adults with type 1 diabetes vs. non-diabetic subjects, including associations with complications and risk factors.<\/jats:p>\n Methods: Cross-sectional study: 178 T1D adults (mean (SD) age: 38 (14) yrs, 21 (14) yrs T1D, HbA1c: 8.0 (1.5) %, 36% with complications (CX+)) ; 132 non-diabetic adults (CON) (age: 37 (14) yrs, HbA1c: 5.1 (0.4) %) . mtDNA-CN by RT-PCR (ScienCell, Carlsbad, CA) in DNA from whole blood samples.<\/jats:p>\n Results: T1D vs. CON: Median (LQ, UQ) mtDNA-CN in T1D vs. CON: 270.8 (189.4, 348.1) vs. 320.5 (264.4, 410.5) ; p&lt;0.0001. mtDNA-CN was lower in T1D with vs. without DKD (238.2 (179.6, 309.1) vs. 293.7 (197.6, 364.4) ; p=0.02, but did not differ by retinopathy or macrovascular disease. T1D mtDNA-CN tertiles: The highest tertile had lowest CX rate (25% (tertile 3) vs. 41% (tertiles 1+2) , p=0.03. Detectable C-peptide rates increased with higher mtDNA-CN tertiles (55%, 69%, 79%, p=0.02) . There were no differences by sex, smoking, BMI status, metabolic syndrome, HbA1c, exercise, statins or ACE\/ARB. Correlates of mtDNA-CN: In T1D: FBG (r=-0.19, p=0.02) , HDL-C (r=0.17, p=0.03) , WCC (r=-0.16, p=0.04) , sVCAM-1 (r=-0.17, p=0.03) and sICAM-1 (r=-0.20, p=0.02) . In CON: WHR (r=-0.22, p=0.03) ; WCC (r=-0.24, p=0.007) . Independent determinants of mtDNA-CN: In T1D: age (-0.25\u00b10.10; p=0.02) , HDL-C (0.27\u00b10.10; p=0.007) , sICAM-1 (-0.42\u00b10.12; p=0.001) . Area under ROC curve 0.72. In CON: pulse pressure (0.25\u00b1013; p=0.047) , WCC (-0.41\u00b10.15; p=0.005) , smoking status (never) (0.22\u00b10.13; p=0.09) ; sex (female) (0.35\u00b10.12; p=0.005) . Area under ROC curve 0.74.<\/jats:p>\n Conclusion: T1D per se is associated with lower mtDNA-CN than CON, particularly with DKD. Higher mtDNA-CN in T1D is associated with detectable C-peptide. Age and inflammation related factors are associated with mtDNA-CN. Longitudinal and intervention studies are merited.<\/jats:p>\n \n Disclosure<\/jats:title>\n A.S.Januszewski: None. L.Carroll: None. Y.W.Loh: None. D.N.O'neal: None. A.Jenkins: Advisory Panel; Abbott Diabetes, Amgen Inc., Board Member; Insulin for Life , International Diabetes Federation Western Pacific Region, Research Support; JDRF, Medtronic, Mylan N.V., NHMRC Australia.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db22-403-p","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T06:15:46Z","timestamp":1653977746000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["403-P: Reduced Mitochondrial DNA Copy Number in Type 1 Diabetes and Nephropathy and Correlates Thereof"],"prefix":"10.2337","volume":"71","author":[{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"first","affiliation":[{"name":"Sydney NSW, Australia, Australia, Australia, Camperdown, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUKE","family":"CARROLL","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Australia, Australia, Camperdown, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YIK W.","family":"LOH","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Australia, Australia, Camperdown, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Australia, Australia, Camperdown, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Australia, Australia, Camperdown, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/403-P\/146611\/403-P-Reduced-Mitochondrial-DNA-Copy-Number-in","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/403-P\/146611\/403-P-Reduced-Mitochondrial-DNA-Copy-Number-in","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T06:15:47Z","timestamp":1653977747000},"score":7.85807,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/403-P\/146611\/403-P-Reduced-Mitochondrial-DNA-Copy-Number-in"}},"issued":{"date-parts":[[2022,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db22-403-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2022,6,1]]},"article-number":"403-P"},{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:20:25Z","timestamp":1773289225820,"version":"3.50.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"Background: Conventional insulin pumps can be inconvenient and increase diabetes distress in people with type 1 diabetes (T1D). A tubeless insulin pump discreetly controlled by a handheld device, may be more acceptable. This is the first randomized controlled trial on patient-reported outcomes with tubeless insulin pumps.<\/jats:p>\n Aim: To compare treatment satisfaction with Omnipod DASH\u00ae Insulin Management System (Insulet, Acton MA) vs. usual care (MDI or conventional IPT) in T1D adults self-monitoring with fingerstick blood glucose.<\/jats:p>\n Methods: T1D adults were randomized to 12-weeks of Omnipod DASH System (intervention) or usual care (control). At study-end, treatment satisfaction was assessed by the difference in Diabetes Technology Questionnaire current score (DTQ-current). Secondary outcomes included patient-reported measures assessed through six other questionnaires and HbA1c.<\/jats:p>\n Results: Baseline characteristics were similar between both groups. Those on Omnipod DASH System expressed significantly higher treatment satisfaction, better sleep quality, reduced fear of hypoglycemia and diabetes distress than those on usual care. HbA1c reduction was clinically relevant in the intervention group.<\/jats:p>\n Conclusion: This study demonstrated that Omnipod DASH System is associated with better treatment satisfaction and patient-reported outcomes whilst maintaining glycemia in T1D adults.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n Y.W.Kong: None. E.I.Ekinci: Advisory Panel; Eli Lilly Australia Pty Limited, Research Support; Eli Lilly Australia Pty Limited, Novo Nordisk, Boehringer Ingelheim and Eli Lilly Alliance, Insulet Corporation, Medtronic. D.N.O'neal: None. C.Yuan: None. K.V.Kiburg: None. K.Brown: None. S.Trawley: Research Support; Insulet Corporation, Juvenile Diabetes Research Foundation (JDRF). A.Partovi: None. K.L.Roem: None. N.Harrison: None. S.Fourlanos: Advisory Panel; Viatris Inc., Pfizer Inc., Speaker's Bureau; Novo Nordisk, AstraZeneca, Boehringer Ingelheim and Eli Lilly Alliance.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Insulet Corporation<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-917-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:38:03Z","timestamp":1687239483000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":2,"title":["917-P: Treatment Satisfaction with Omnipod DASH System vs. Usual Care in Adults with Type 1 Diabetes in Australia"],"prefix":"10.2337","volume":"72","author":[{"given":"YEE W.","family":"KONG","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHENG","family":"YI YUAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATERINA V.","family":"KIBURG","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATRIN","family":"BROWN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEVEN","family":"TRAWLEY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDISHEH","family":"PARTOVI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KERRYN L.","family":"ROEM","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NATALIE","family":"HARRISON","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SPIROS","family":"FOURLANOS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIF I.","family":"EKINCI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/917-P\/149840\/917-P-Treatment-Satisfaction-with-Omnipod-DASH","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/917-P\/149840\/917-P-Treatment-Satisfaction-with-Omnipod-DASH","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:38:03Z","timestamp":1687239483000},"score":7.846179,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/917-P\/149840\/917-P-Treatment-Satisfaction-with-Omnipod-DASH"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-917-p","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"917-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:30Z","timestamp":1753890030336,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Background: A missed or late meal insulin bolus can impact glycemia in type 1 diabetes (T1D).<\/jats:p>\n Aim: To study glucose control after missed and late meal boluses in T1D adults using a prototype enhanced hybrid closed-loop (E-HCL) system (Medtronic) providing automated basal insulin and correction boluses.<\/jats:p>\n Methods: Twelve T1D adults (median HbA1c 6.8% [IQR 6.2-7.2] | 51mmol\/mol [44-55] participated. After 1-week run-in at home in Open Loop, E-HCL was activated during 1-week supervised hotel phase followed by 3 weeks free-living at-home. Participants consumed a standardized 40g carbohydrate dinner in the supervised phase. Four hours of post-prandial glucose data following a standard bolus pre-meal in E-HCL at home were compared in a pairwise manner to 1) Pre-meal bolus in Open Loop Run-In; 2) 20minute Late bolus in E-HCL supervised; 3) Missed bolus in E-HCL supervised using Wilcoxon Signed-Rank Test.<\/jats:p>\n Results: Late bolus was associated with mild hypoglycemia and higher glucose variability; missed bolus was associated with hyperglycemia (Table). Overall time in CL was 99.98%. E-HCL at home vs. Open Loop (run-in) had greater time-in-70-180mg\/dL range (85.3 vs. 75.0%, p=0.003). There was no severe hypoglycemia or ketoacidosis.<\/jats:p>\n Conclusions: While glucose excursions were modest, the administration and timing of meal boluses influenced post-meal glycemia in well-controlled T1D adults using E-HCL.<\/jats:p>\n \n Disclosure<\/jats:title>\n M.H. Lee: Research Support; Self; Medtronic. Speaker's Bureau; Self; AstraZeneca. S. Vogrin: None. B. Paldus: Other Relationship; Self; Australian Diabetes Society, JDRF, Medtronic. H. Jones: None. V.R. Obeyesekere: None. C.M. Sims: Stock\/Shareholder; Self; Medtronic. S.A. Wyatt: Other Relationship; Self; Animas Corporation, Medtronic. G.M. Ward: None. S.A. McAuley: Research Support; Self; JDRF, Medtronic. Speaker's Bureau; Self; Australian Diabetes Society, Eli Lilly and Company. R. MacIsaac: Advisory Panel; Self; AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Novo Nordisk Inc. Speaker's Bureau; Self; AstraZeneca, Novo Nordisk Inc. Other Relationship; Self; AstraZeneca, Novo Nordisk Inc. B. Krishnamurthy: None. V. Sundararajan: None. A. Jenkins: Advisory Panel; Self; Abbott, Australian Diabetes Society, Medtronic. Research Support; Self; Abbott, GlySens Incorporated, Medtronic, Mylan. Speaker's Bureau; Self; Eli Lilly and Company, Novo Nordisk Inc. D.N. O'Neal: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-1037-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:28:47Z","timestamp":1559694527000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1037-P: Glucose Control following Missed and Late Meal Boluses with a Medtronic Enhanced-Hybrid Closed-Loop (E-HCL) System"],"prefix":"10.2337","volume":"68","author":[{"given":"MELISSA H.","family":"LEE","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SARA","family":"VOGRIN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BARBORA","family":"PALDUS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HANNAH","family":"JONES","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VARUNI R.","family":"OBEYESEKERE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CATRIONA M.","family":"SIMS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUE A.","family":"WYATT","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GLENN M.","family":"WARD","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SYBIL A.","family":"MCAULEY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"MACISAAC","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BALASUBRAMANIAN","family":"KRISHNAMURTHY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VIJAYA","family":"SUNDARARAJAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1037-P\/58756\/1037-P-Glucose-Control-following-Missed-and-Late","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1037-P\/58756\/1037-P-Glucose-Control-following-Missed-and-Late","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:01:34Z","timestamp":1647165694000},"score":7.842615,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1037-P\/58756\/1037-P-Glucose-Control-following-Missed-and-Late"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-1037-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"1037-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:31Z","timestamp":1753889791769,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"Background: Tubeless insulin pump therapy (IPT) offers an alternative to tubed insulin pumps and multi-dose injections (MDI) for people with type 1 diabetes (T1D). No formal interview studies have explored individual's lived experiences of using tubeless IPT.<\/jats:p>\n Aim: To gain insight into the lived experience of using a tubeless IPT system compared to usual tubed IPT or MDI care.<\/jats:p>\n Methods: Interviews were conducted 12-weeks after using an Omnipod DASH\u00ae Insulin Management System (Insulet, Acton MA) in a randomised controlled trial. The interview transcripts were subject to a thematic analysis, a method for identifying patterned meaning across datasets.<\/jats:p>\n Results: Thirty-six adults (24 female; age 43\u00b114 years; 21 previous MDI) were interviewed. Overall experiences of the Omnipod DASH were encompassed by 3 major themes: 1. Taking back control of my diabetes: many previous MDI users perceived improvement in glycaemic control, explained by more accurate insulin dosing, with some reporting positive effects during exercise and sleep. 2. Taking back control of the narrative: many previous MDI and IPT users endorsed positive experiences in relation to concealing or disclosing their diabetes to others (\u201cyou can hide it if you want to, you can let it be seen if you want to\u201d). However, some previous MDI users reported negative psychosocial experiences due to the visibility of their diabetes and continuous device attachment (\u201c\u2026it's always there, whereas with the needles, you just set and forget\u201d). 3. Barriers affecting long-term use: many participants reported wearability issues, alarm issues and the financial burden of the device. However, the majority indicated they would use and recommend tubeless IPT to others with T1D.<\/jats:p>\n Conclusion: Perceptions regarding tubeless IPT were related to individual needs and lifestyle, with previous treatment experience playing an important role. This work highlights the importance of understanding lived experience for future device development.<\/jats:p>\n \n Disclosure<\/jats:title>\n A.P.Stocco: None. S.Fourlanos: Advisory Panel; Viatris Inc., Pfizer Inc., Speaker's Bureau; Novo Nordisk, AstraZeneca, Boehringer Ingelheim and Eli Lilly Alliance. E.I.Ekinci: Advisory Panel; Eli Lilly Australia Pty Limited, Research Support; Eli Lilly Australia Pty Limited, Novo Nordisk, Boehringer Ingelheim and Eli Lilly Alliance, Insulet Corporation, Medtronic. D.N.O'neal: None. S.Trawley: Research Support; Insulet Corporation, Juvenile Diabetes Research Foundation (JDRF). Y.W.Kong: None. C.Yuan: None. K.V.Kiburg: None. K.Brown: None. A.Partovi: None. K.L.Roem: None. N.Harrison: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-683-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:19:04Z","timestamp":1687241944000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["683-P: Lived Experiences of Using Omnipod DASH System among Australians with Type 1 Diabetes\u2014A Qualitative Study"],"prefix":"10.2337","volume":"72","author":[{"given":"AMBER P.","family":"STOCCO","sequence":"first","affiliation":[{"name":"Hawthorn East, Australia, Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEVEN","family":"TRAWLEY","sequence":"additional","affiliation":[{"name":"Hawthorn East, Australia, Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YEE W.","family":"KONG","sequence":"additional","affiliation":[{"name":"Hawthorn East, Australia, Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHENG","family":"YI YUAN","sequence":"additional","affiliation":[{"name":"Hawthorn East, Australia, Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATERINA V.","family":"KIBURG","sequence":"additional","affiliation":[{"name":"Hawthorn East, Australia, Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATRIN","family":"BROWN","sequence":"additional","affiliation":[{"name":"Hawthorn East, Australia, Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDISHEH","family":"PARTOVI","sequence":"additional","affiliation":[{"name":"Hawthorn East, Australia, Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KERRYN L.","family":"ROEM","sequence":"additional","affiliation":[{"name":"Hawthorn East, Australia, Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NATALIE","family":"HARRISON","sequence":"additional","affiliation":[{"name":"Hawthorn East, Australia, Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SPIROS","family":"FOURLANOS","sequence":"additional","affiliation":[{"name":"Hawthorn East, Australia, Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIF I.","family":"EKINCI","sequence":"additional","affiliation":[{"name":"Hawthorn East, Australia, Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Hawthorn East, Australia, Melbourne, Australia, Fitzroy, Australia, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/683-P\/150625\/683-P-Lived-Experiences-of-Using-Omnipod-DASH","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/683-P\/150625\/683-P-Lived-Experiences-of-Using-Omnipod-DASH","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:19:05Z","timestamp":1687241945000},"score":7.8412414,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/683-P\/150625\/683-P-Lived-Experiences-of-Using-Omnipod-DASH"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-683-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"683-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:43Z","timestamp":1753890043730,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: We aim to profile ketone levels in free-living people with type 1 diabetes (T1D).<\/jats:p>\n Methods: In addition to demographic, anthropometric, HbA1c and CGM (Abbott Freestyle Libre 2) data, interstitial ketone profiles were assessed 5-minutely with a novel subcutaneously-inserted continuous ketone monitor (CKM, Abbott) during a 2 week run-in for the PARTNER Study (ACTRN12624000448549) where prior SGLT2 inhibitor use was an exclusion.<\/jats:p>\n Results: Twelve participants (4 female (33.3%); Age 49.4 (33.0 - 63.6) years; HbA1c 54.1 (48.6 - 58.5) mmol\/mol) have been studied to date (16.7% MDI and 83.3% AID). The majority (n=10, 83.3%) had ketone profiles that were &lt;0.6mmol\/L throughout the 2 weeks. Two participants had ketones &gt;0.6 mmol\/L (0.4% and 2.7% time with ketones 0.6-0.9mmol\/L; 0.0% and 0.3% time with ketones 1.0-1.5mmol\/L respectively, highest ketone 1.1mmol\/L for the latter). Both were males with T1D for at least 10 years and undetectable C-peptide levels, on automated insulin delivery systems with excellent glycemia (HbA1c&lt;53 mmol\/mol or &lt;7%) and with total daily insulin doses 0.38 and 0.56 units\/kg.<\/jats:p>\n Conclusion: Whilst the majority of T1D adults had stable normal ketone levels, a small proportion had acceptable\/elevated baseline ketone levels. We aim to determine the factors that could help predict those with T1D who would be at higher risk of diabetic ketoacidosis.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n J. Ngan: None. Y.W. Kong: None. J.L. Goad: None. M.L. Huang: None. A. Jenkins: Advisory Panel; Abbott. Speaker's Bureau; GlaxoSmithKline plc. Research Support; Abbott, Metronics, Ypsomed AG, Insulet Corporation, Jaeb Center for Health Research, Endogenex, Hemsley Charitable Trust. Speaker's Bureau; CSL Seqirus. Research Support; AbbVie Inc, National Institutes of Health, Juvenile Diabetes Research Foundation (JDRF). S. Vogrin: None. S. Trawley: None. E.I. Ekinci: Research Support; Amgen Inc, Novo Nordisk, Lilly Diabetes, AstraZeneca, Endogenex, Versanis. Advisory Panel; Lilly Diabetes, Novo Nordisk. A. Kriketos: None. S. Fourlanos: Speaker's Bureau; Novo Nordisk, Boehringer-Ingelheim. Research Support; Dexcom, Inc. C.J. Nolan: None. P.V. Taylor: Research Support; Eli Lilly and Company, Novo Nordisk, Boehringer-Ingelheim. J. Fenn: Research Support; Eli Lilly and Company, Novo Nordisk, Boehringer-Ingelheim, Amgen Inc, ACADI. S. Stranks: None. D.N. O'Neal: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Australian Centre for Accelerating Diabetes Innovations and Breakthrough T1D (2-SRA-2025-1614-M-B)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-1003-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T06:56:22Z","timestamp":1749797782000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["1003-P: Ketone Profiles in Free-living People with Type 1 Diabetes Using Continuous Ketone Monitoring"],"prefix":"10.2337","volume":"74","author":[{"given":"JENNIFER","family":"NGAN","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Melbournse, Australia, Parkville, Australia, Woden, Australia, Oaklands Park, SA, Australia, Oaklands Park, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YEE W.","family":"KONG","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Melbournse, Australia, Parkville, Australia, Woden, Australia, Oaklands Park, SA, Australia, Oaklands Park, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENNA L.","family":"GOAD","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Melbournse, Australia, Parkville, Australia, Woden, Australia, Oaklands Park, SA, Australia, Oaklands Park, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL L-H.","family":"HUANG","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Melbournse, Australia, Parkville, Australia, Woden, Australia, Oaklands Park, SA, Australia, Oaklands Park, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Melbournse, Australia, Parkville, Australia, Woden, Australia, Oaklands Park, SA, Australia, Oaklands Park, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SARA","family":"VOGRIN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Melbournse, Australia, Parkville, Australia, Woden, Australia, Oaklands Park, SA, Australia, Oaklands Park, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEVEN","family":"TRAWLEY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Melbournse, Australia, Parkville, Australia, Woden, Australia, Oaklands Park, SA, Australia, Oaklands Park, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIF I.","family":"EKINCI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Melbournse, Australia, Parkville, Australia, Woden, Australia, Oaklands Park, SA, Australia, Oaklands Park, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ADAMANDIA","family":"KRIKETOS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Melbournse, Australia, Parkville, Australia, Woden, Australia, Oaklands Park, SA, Australia, Oaklands Park, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SPIROS","family":"FOURLANOS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Melbournse, Australia, Parkville, Australia, Woden, Australia, Oaklands Park, SA, Australia, Oaklands Park, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTOPHER J.","family":"NOLAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Melbournse, Australia, Parkville, Australia, Woden, Australia, Oaklands Park, SA, Australia, Oaklands Park, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAMELA V.","family":"TAYLOR","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Melbournse, Australia, Parkville, Australia, Woden, Australia, Oaklands Park, SA, Australia, Oaklands Park, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOANNE","family":"FENN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Melbournse, Australia, Parkville, Australia, Woden, Australia, Oaklands Park, SA, Australia, Oaklands Park, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN","family":"STRANKS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Melbournse, Australia, Parkville, Australia, Woden, Australia, Oaklands Park, SA, Australia, Oaklands Park, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Melbournse, Australia, Parkville, Australia, Woden, Australia, Oaklands Park, SA, Australia, Oaklands Park, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1003-P\/159422\/1003-P-Ketone-Profiles-in-Free-living-People-with","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1003-P\/159422\/1003-P-Ketone-Profiles-in-Free-living-People-with","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T16:26:51Z","timestamp":1750436811000},"score":7.839763,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1003-P\/159422\/1003-P-Ketone-Profiles-in-Free-living-People-with"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-1003-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"1003-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:11Z","timestamp":1753889771056,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: There has been a growing interest in the utility of continuous glucose monitoring (CGM) in type 1 diabetes (T1D) to better define the glycaemic impact of beta-cell preservation trials and as a surrogate for the current gold standard measurement of beta-cell function, the area under the curve (AUC) of meal-stimulated C-peptide. We aimed to determine the relationship between CGM metrics and meal-stimulated C-peptide in the first 2 years after diagnosis, and the relationship between glucagon and C-peptide in the BANDIT study participants.<\/jats:p>\n Methods: BANDIT was a randomised, placebo-controlled study of 91 new-onset T1D participants aged 10-30 years. Participants were randomised 2:1 to baricitinib or placebo for 48 weeks, followed by a 48-week off-treatment period. CGM 14-day data, meal-stimulated C-peptide and glucagon were available at 0, 12, 24, 48, 72 and 96 weeks. The proportion of variance of the CGM metric explained by C-peptide or glucagon at all time points combined was examined (r2 metric).<\/jats:p>\n Results: Meal-stimulated C-peptide had a significant relationship with glycaemic variability (SD r2 of 0.25; p&lt;0.001), time in range (TIR; r2 0.23; p&lt;0.001) and time above range (r2 0.21; p&lt;0.001) in new-onset T1D. Adjustment for confounders (i.e. age, insulin dose, BMI and insulin pump use), strengthened the relationship between C-peptide and all CGM metrics, except for time below range. C-peptide explained &gt;40% variance in TIR (adjusted r2 0.41; p&lt;0.001); every 10% increase in C-peptide resulting in a 4% increase in TIR. Alpha-cell function \/ glucagon had no impact on the relationship between C-peptide and CGM metrics, nor a strong relationship with beta-cell function or CGM.<\/jats:p>\n Conclusion: Glucose control measured by CGM correlates strongly with meal-stimulated C-peptide production in the first 2 years of T1D diagnosis. Meal-stimulated glucagon does not correlate with beta cell function or impact glucose control in new-onset T1D.<\/jats:p>\n \n Disclosure<\/jats:title>\n M. So: None. S. Vogrin: None. B. Krishnamurthy: None. M. Waibel: None. J.J. Couper: None. F. Cameron: None. M.E. Craig: None. J.Y. Gong: None. J. Wentworth: None. T. Kay: Advisory Panel; Sanofi, SAB Biotherapeutics, Inc.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Supported by JDRF International and JDRF Australia; a grant(4-SRA-2020-912-M-B) from the Australian Government Department of Health through the Emerging Priorities and Consumer-Driven Research Initiative, part of the Medical Research Future Fund; a grant (GNT1150425) from the National Health and Medical Research Council of Australia<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-1198-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:19:32Z","timestamp":1749791972000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1198-P: Relationship between CGM Metrics and Beta-Cell Function in First Two Years after Diagnosis of Type 1 Diabetes (BANDIT Study)"],"prefix":"10.2337","volume":"74","author":[{"given":"MICHELLE","family":"SO","sequence":"first","affiliation":[{"name":"Fitzroy, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SARA","family":"VOGRIN","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BALASUBRAMANIAN","family":"KRISHNAMURTHY","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAELA","family":"WAIBEL","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENNIFER J.","family":"COUPER","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FERGUS","family":"CAMERON","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA E.","family":"CRAIG","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOANNA Y.","family":"GONG","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN","family":"WENTWORTH","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"THOMAS","family":"KAY","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1198-P\/158685\/1198-P-Relationship-between-CGM-Metrics-and-Beta","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1198-P\/158685\/1198-P-Relationship-between-CGM-Metrics-and-Beta","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T15:48:42Z","timestamp":1750434522000},"score":7.838243,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1198-P\/158685\/1198-P-Relationship-between-CGM-Metrics-and-Beta"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-1198-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"1198-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:06Z","timestamp":1753889766573,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Aims: To evaluate burden of cardiovascular risk factors and associations with cardiovascular disease (CVD) among adults with type 1 diabetes attending Australian diabetes centers.<\/jats:p>\n Methods: De-identified, prospectively collected data from patients with type 1 diabetes aged \u226518 years included in ANDA-2015 were analysed. Cardiovascular risk factors (age, sex, diabetes duration, HbA1c, BP, high density lipoprotein-cholesterol (HDL-C), BMI, smoking status and albuminuria) and associations with CVD inclusive of stroke, myocardial infarction, coronary artery bypass graft\/angioplasty and peripheral vascular disease were assessed. Likelihood ratio test and restricted cubic splines assessed for interactions and non-linear associations. Discriminatory ability of multivariate models was assessed with area under the receiver operating characteristic curves (AUC).<\/jats:p>\n Results: Data from 1,169 patients were analysed. Median (IQR) age and diabetes duration were 37.0 (24.9-52.0) and 16.0 (8.0-27.0) years respectively. Cardiovascular risk factors were prevalent including hypertension (22%), dyslipidemia (89%), overweight or obesity (56%), ever smoking (39%), albuminuria (31%), and an HbA1c &gt;7.0% (53mmol\/mol) (81%). Older age, longer diabetes duration, smoking and antihypertensive use were positively associated, while higher HDL-C was negatively associated with CVD (all p&lt;0.05). Association with CVD and diabetes duration remained constant until 20 years when a linear increase was noted. The multivariate model demonstrated good discriminatory ability for CVD (AUC 0.88; 95% CI 0.85-0.92).<\/jats:p>\n Conclusions: Cardiovascular risk factors were prevalent and strongly associated with CVD among adults with type 1 diabetes. Given the approximate J-shaped association between diabetes duration and CVD, the impact of cardiovascular risk stratification and management before and after 20 years duration will need to be further assessed.<\/jats:p>\n \n Disclosure<\/jats:title>\n A.J. Pease: None. A. Earnest: None. N. Nanayakkara: None. S. Ranasinha: None. J.R. Flack: None. W.A. Davis: Speaker's Bureau; Self; Eli Lilly and Company. Speaker's Bureau; Spouse\/Partner; Novo Nordisk A\/S. Advisory Panel; Spouse\/Partner; Novo Nordisk A\/S. Research Support; Spouse\/Partner; Novo Nordisk A\/S. Other Relationship; Spouse\/Partner; Novo Nordisk A\/S. Speaker's Bureau; Spouse\/Partner; Merck Sharp & Dohme Corp.. Advisory Panel; Spouse\/Partner; Merck Sharp & Dohme Corp.. Speaker's Bureau; Spouse\/Partner; AstraZeneca. Advisory Panel; Spouse\/Partner; AstraZeneca. Speaker's Bureau; Spouse\/Partner; Boehringer Ingelheim GmbH, Pfizer Inc.. G.M. Kilmartin: None. N. Wischer: None. S. Zoungas: Advisory Panel; Self; AstraZeneca.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-1697-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:32Z","timestamp":1529693852000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Burden of Cardiovascular Risk Factors and Disease in Type 1 Diabetes\u2014Results of the Australian National Diabetes Audit (ANDA)"],"prefix":"10.2337","volume":"67","author":[{"given":"ANTHONY J.","family":"PEASE","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Clayton, Australia, Bankstown, Australia, Fremantle, Australia, Shepparton, Australia, Ghin Ghin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ARUL","family":"EARNEST","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Clayton, Australia, Bankstown, Australia, Fremantle, Australia, Shepparton, Australia, Ghin Ghin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NATALIE","family":"NANAYAKKARA","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Clayton, Australia, Bankstown, Australia, Fremantle, Australia, Shepparton, Australia, Ghin Ghin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SANJEEVA","family":"RANASINHA","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Clayton, Australia, Bankstown, Australia, Fremantle, Australia, Shepparton, Australia, Ghin Ghin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEFF R.","family":"FLACK","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Clayton, Australia, Bankstown, Australia, Fremantle, Australia, Shepparton, Australia, Ghin Ghin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WENDY A.","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Clayton, Australia, Bankstown, Australia, Fremantle, Australia, Shepparton, Australia, Ghin Ghin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GLORIA M.","family":"KILMARTIN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Clayton, Australia, Bankstown, Australia, Fremantle, Australia, Shepparton, Australia, Ghin Ghin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NATALIE","family":"WISCHER","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Clayton, Australia, Bankstown, Australia, Fremantle, Australia, Shepparton, Australia, Ghin Ghin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SOPHIA","family":"ZOUNGAS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Clayton, Australia, Bankstown, Australia, Fremantle, Australia, Shepparton, Australia, Ghin Ghin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1697-P\/54480\/Burden-of-Cardiovascular-Risk-Factors-and-Disease","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1697-P\/54480\/Burden-of-Cardiovascular-Risk-Factors-and-Disease","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T10:47:37Z","timestamp":1652698057000},"score":7.8337984,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1697-P\/54480\/Burden-of-Cardiovascular-Risk-Factors-and-Disease"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-1697-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"1697-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:38:36Z","timestamp":1753889916708,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2021,6,1]]},"DOI":"10.2337\/db21-699-p","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T22:15:03Z","timestamp":1624572903000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["699-P: Prerandomization Factors Associated with Time-in-Target Glucose Range with Hybrid Closed-Loop Use in a Six-Month Randomized Controlled Trial in Adults with Type 1 Diabetes"],"prefix":"10.2337","volume":"70","author":[{"given":"ALICIA","family":"JENKINS","sequence":"first","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ADRIENNE","family":"KIRBY","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SYBIL A.","family":"MCAULEY","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MELISSA H.","family":"LEE","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BARBORA","family":"PALDUS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SARA","family":"VOGRIN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTIN DE","family":"BOCK","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MORTON","family":"BURT","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NEALE","family":"COHEN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER G.","family":"COLMAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH A.","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANE","family":"HOLMES-WALKER","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTHONY C.","family":"KEECH","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"MACISAAC","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CATRIONA M.","family":"SIMS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VIJAYA","family":"SUNDARARAJAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEVEN","family":"TRAWLEY","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GLENN M.","family":"WARD","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIM","family":"JONES","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O\u2019NEAL","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Adelaide, Australia, Melbourne, Australia, Parkville, Australia, Perth, Australia, Westmead, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"JDRF AUSTRALIA ADULT HYBRID CLOSED LOOP TRIA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/699-P\/140790\/699-P-Prerandomization-Factors-Associated-with","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/699-P\/140790\/699-P-Prerandomization-Factors-Associated-with","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T11:42:57Z","timestamp":1647171777000},"score":7.8317423,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/699-P\/140790\/699-P-Prerandomization-Factors-Associated-with"}},"issued":{"date-parts":[[2021,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db21-699-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2021,6,1]]},"article-number":"699-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:39:14Z","timestamp":1753889954060,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and is the leading cause of ESKD. The role of T lymphocytes in DKD remains unclear. We aimed to determine the distribution of T lymphocytes in renal biopsies in people with T2DM with varying degrees of kidney function and albuminuria. Fresh renal biopsy samples were provided by the Victorian Cancer Biobank at the time of surgery from individuals undergoing partial\/complete nephrectomy or from people with diabetes who had a renal biopsy for clinical indications at Austin Health. Participants were divided into the following groups: Diabetic kidney disease group (DKD was diagnosed by clinical and histologic characteristics), nondiabetic and intact renal function (Control) (eGFR &gt; 60ml\/min\/m2, no albuminuria) and nondiabetic kidney disease (NDKD) (eGFR &lt; 60ml\/min\/m2, no history of diabetes). DKD group was further stratified into normo-, micro-, or macroalbuminuria groups. Sections were immunostained with CD3 antibody. Results showed higher level of creatinine, systolic blood pressure, and reduced level of eGFR, poor glycemic control in people with DKD and macroalbuminuria as compared with people without diabetes. T lymphocytes numbers were significantly increased in the interstitial compartment of people with T2DM and macroalbuminuria compared to those without diabetes, suggesting the immunopathologic role of T lymphocytes in the development of DKD.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n L. Kong: None. S. Andrikopoulos: None. R. MacIsaac: None. N. Torkamani: None. M. Coughlan: None. D. Power: None. E.C. Marin: None. L.K. Mackay: None. E.I. Ekinci: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-485-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:52Z","timestamp":1592238592000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["485-P: T Lymphocytes Infiltration in Kidneys of People with Type 2 Diabetes"],"prefix":"10.2337","volume":"69","author":[{"given":"LINGYUN","family":"KONG","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SOF","family":"ANDRIKOPOULOS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"MACISAAC","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NILOUFAR","family":"TORKAMANI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MELINDA","family":"COUGHLAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"POWER","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EVELYN C.","family":"MARIN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LAURA K.","family":"MACKAY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIF I.","family":"EKINCI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/485-P\/57954\/485-P-T-Lymphocytes-Infiltration-in-Kidneys-of","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/485-P\/57954\/485-P-T-Lymphocytes-Infiltration-in-Kidneys-of","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:46:56Z","timestamp":1647164816000},"score":7.826812,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/485-P\/57954\/485-P-T-Lymphocytes-Infiltration-in-Kidneys-of"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-485-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"485-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:30Z","timestamp":1753889790585,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Introduction: Current ISPAD guidelines recommend biennial diabetic retinopathy (DR) screening starting at age 11 yrs with type 1 diabetes (T1D) duration 2-5 yrs. Growing evidence suggesting less frequent screening.<\/jats:p>\n Methods: DR was ETDRS graded and progress assed by Markov chain model analysis. Retinal photos were from 2,169 patients (baseline (mean\u00b1SD): age 13.1\u00b12.1 yrs, HbA1c 8.5\u00b11.4%, 5.4\u00b12.9 yrs T1D, follow-up 5.3\u00b13.6 yrs) who attended the T1D clinic at least twice in 1990-2018.<\/jats:p>\n Results: In 11\/2,169 patients DR progressed to severe non-proliferative (SNP) DR or above. See tables 1 and 2 below for detailed results.<\/jats:p>\n Conclusions: Our data support less frequent DR screening in T1D youth without any DR. Although DR progression is generally slow, poor glycaemic control greatly accelerates it.<\/jats:p>\n \n \n \n Disclosure<\/jats:title>\n A.S. Januszewski: None. V. Velayutham: None. P.Z. Benitez-Aguirre: None. M.E. Craig: None. G. Liew: None. Y. Cho: None. A. Jenkins: Advisory Panel; Self; Abbott, Medtronic. Research Support; Self; Abbott, GlySens Incorporated, Medtronic, Sanofi-Aventis. K.C. Donaghue: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-328-or","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:52Z","timestamp":1592238592000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["328-OR: Retinopathy Screening in Adolescents with Type 1 Diabetes"],"prefix":"10.2337","volume":"69","author":[{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"first","affiliation":[{"name":"Sydney, Australia, Campbelltown, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VALLIMAYIL","family":"VELAYUTHAM","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Campbelltown, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL Z.","family":"BENITEZ-AGUIRRE","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Campbelltown, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA E.","family":"CRAIG","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Campbelltown, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GERALD","family":"LIEW","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Campbelltown, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOON HI","family":"CHO","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Campbelltown, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Campbelltown, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KIM C.","family":"DONAGHUE","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Campbelltown, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/328-OR\/56378\/328-OR-Retinopathy-Screening-in-Adolescents-with","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/328-OR\/56378\/328-OR-Retinopathy-Screening-in-Adolescents-with","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:29:33Z","timestamp":1647163773000},"score":7.826264,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/328-OR\/56378\/328-OR-Retinopathy-Screening-in-Adolescents-with"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-328-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"328-OR"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:09Z","timestamp":1753889829158,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Background: Comparative, real-world evidence for clinical outcomes of different glucose lowering pharmacotherapy regimens in diabetes is limited. We compared therapy persistence and achieved HbA1c amongst episodes of different pharmacotherapy regimens in a community-based Australian cohort.<\/jats:p>\n Methods: The EXTEND45 Study combines baseline questionnaire responses (2006-2009) with data from community pathology providers, the Medicare Benefits Schedule (MBS) and Pharmaceutical Benefits Scheme (PBS) (provided by the Department of Human Services) and other routinely collected health databases for participants of the 45 and Up study for the period 2005 to 2014. Linkage of MBS and PBS data was performed by the Sax Institute and all other data sources by the Centre for Health Record Linkage. We identified 24,236 people aged \u226545 years with diabetes. Using treatment episodes as our unit of analysis, the persistence and achieved glycaemic control of episodes was compared according to therapy regimens using Wilcoxon Sum rank tests.<\/jats:p>\n Results: Among 149,532 episodes, mean (median) therapy persistence was 163 (76), 175 (84), 132 (54) and 164 (108) days for mono-, dual, multioral-, and insulin-based therapy episodes, respectively. For monotherapy episodes, mean persistence was greatest for metformin (178 days). For dual therapy, mean persistence was longest for combinations that did not involve metformin or a sulfonylurea (195 days). Mean HbA1c was 6.9%, 7.3%, 7.4% and 7.9% for mono-, dual, multioral-, and insulin-based therapy episodes, respectively. For monotherapy episodes, mean HbA1c was lowest for metformin (6.8%) whilst for dual therapy, mean persistence was highest for sulfonylurea combinations that did not involve metformin (7.5%).<\/jats:p>\n Conclusion: Persistence with therapy is heterogeneous across different intensities of therapy and is shortest for multioral-agent regimens. Participants requiring insulin therapy have the highest achieved HbA1c, which is likely to reflect disease severity.<\/jats:p>\n \n Disclosure<\/jats:title>\n T.K. Young: None. C. Hockham: None. L. Sukkar: None. A. Kang: None. M. Jun: Research Support; Self; AstraZeneca. J. Baker: None. K. Rogers: None. A. Cass: None. C.A. Pollock: Advisory Panel; Self; AstraZeneca, Merck Sharp & Dohme Corp., Otsuka Pharmaceutical Co., Ltd., Vifor Pharma. Board Member; Self; Boehringer Ingelheim Pharmaceuticals, Inc. Speaker's Bureau; Self; Amgen Inc., AstraZeneca, Novartis AG, Vifor Pharma. Other Relationship; Self; Janssen Pharmaceuticals, Inc. D. Sullivan: None. G. Wong: None. M.J. Jardine: Advisory Panel; Self; Akebia Therapeutics, Baxter, Boehringer Ingelheim International GmbH, CSL Behring, Vifor Pharma. Research Support; Self; Amgen Inc., Baxter, Eli Lilly and Company, Gambro, Merck Sharp & Dohme Corp. Speaker's Bureau; Self; Janssen Pharmaceuticals, Inc. Other Relationship; Self; Janssen Pharmaceuticals, Inc.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Heart Foundation of Australia (100720); Roche Products Pty Ltd. (FR-MIR-0095); Rebecca L. Cooper Grant (REB002); Eli Lilly Australia Pty Ltd. (PO4100294024); Merck Sharp & Dohme Australia Pty Ltd. (MSD_EXTEND45); Amgen Australia Pty Ltd. (Amgen01)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-1129-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:36:26Z","timestamp":1559694986000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1129-P: Association between the Intensity of Diabetes Therapy, Achieved HbA1c, and Persistence"],"prefix":"10.2337","volume":"68","author":[{"given":"TAMARA K.","family":"YOUNG","sequence":"first","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARINNA","family":"HOCKHAM","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LOUISA","family":"SUKKAR","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AMY","family":"KANG","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIN","family":"JUN","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANNAH","family":"BAKER","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KRIS","family":"ROGERS","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALAN","family":"CASS","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CAROL A.","family":"POLLOCK","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"SULLIVAN","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GERMAINE","family":"WONG","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MEG J.","family":"JARDINE","sequence":"additional","affiliation":[{"name":"Newtown, Australia, Sydney, Australia, Darwin, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"EXTEND45 STUDY STEERING COMMITTEE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1129-P\/58531\/1129-P-Association-between-the-Intensity-of","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1129-P\/58531\/1129-P-Association-between-the-Intensity-of","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:58:20Z","timestamp":1647165500000},"score":7.8248916,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1129-P\/58531\/1129-P-Association-between-the-Intensity-of"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-1129-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"1129-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:08Z","timestamp":1753889828435,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Dietary protein increases the postprandial glycemic response and insulin requirements in people with type 1 diabetes (T1D). The aim of this study was to determine the appropriate amount of additional insulin required for the protein content of a meal to prevent postprandial hyperglycemia. Twenty-nine subjects (12 male) with T1D using CSII (HbA1c&lt;8.1%\/65mmol\/mol) aged 10-40 years consumed 5 test meals containing 50g protein, 0g fat and 30g CHO. Insulin doses were calculated based on the individual insulin:CHO ratio with 0 (standard), 15, 30, 45 and 60% additional insulin added to the dose and delivered over 3 hours using a dual\/combination bolus. Postprandial glycemia was assessed by 4 hours of CGM. Standard insulin dosing resulted in delayed and sustained postprandial hyperglycemia. From 150 minutes, additional insulin doses of 30% resulted in significantly lower postprandial glycemic excursions, returning to baseline by 4 hours; compared with 0-15% additional insulin (p&lt;0.05). Additional insulin doses of 45 and 60% resulted in increased episodes of hypoglycemia in 50% (n=15) and 80% (n=23) of participants respectively. This study demonstrates that adding 30% more insulin to a standard meal-time dose for a high protein meal, delivered using a dual\/combination bolus, improves postprandial glycemia in individuals with T1D using CSII.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n M.A. Paterson: None. C.E. Smart: None. J. Rafferty: None. B. Fenton: None. D. Price: None. D.C. Foskett: None. A. Maher: None. P. Howley: None. B.R. King: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n John Hunter Children's Hospital; Dexcom External Research Program<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-330-or","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T02:49:06Z","timestamp":1559702946000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["330-OR: A 30% Increased Insulin Dose Is Necessary to Control Postprandial Hyperglycemia for High Protein Meals in Individuals with Type 1 Diabetes Using Insulin Pump Therapy"],"prefix":"10.2337","volume":"68","author":[{"given":"MEGAN A.","family":"PATERSON","sequence":"first","affiliation":[{"name":"New Lambton Heights, Australia, Newcastle, Australia, Gosford, Australia, Southport, Australia, Gold Coast, Australia, Callaghan, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARMEL E.","family":"SMART","sequence":"additional","affiliation":[{"name":"New Lambton Heights, Australia, Newcastle, Australia, Gosford, Australia, Southport, Australia, Gold Coast, Australia, Callaghan, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JORDAN","family":"RAFFERTY","sequence":"additional","affiliation":[{"name":"New Lambton Heights, Australia, Newcastle, Australia, Gosford, Australia, Southport, Australia, Gold Coast, Australia, Callaghan, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRETT","family":"FENTON","sequence":"additional","affiliation":[{"name":"New Lambton Heights, Australia, Newcastle, Australia, Gosford, Australia, Southport, Australia, Gold Coast, Australia, Callaghan, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DARRELL","family":"PRICE","sequence":"additional","affiliation":[{"name":"New Lambton Heights, Australia, Newcastle, Australia, Gosford, Australia, Southport, Australia, Gold Coast, Australia, Callaghan, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DEBORAH C.","family":"FOSKETT","sequence":"additional","affiliation":[{"name":"New Lambton Heights, Australia, Newcastle, Australia, Gosford, Australia, Southport, Australia, Gold Coast, Australia, Callaghan, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREW","family":"MAHER","sequence":"additional","affiliation":[{"name":"New Lambton Heights, Australia, Newcastle, Australia, Gosford, Australia, Southport, Australia, Gold Coast, Australia, Callaghan, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER","family":"HOWLEY","sequence":"additional","affiliation":[{"name":"New Lambton Heights, Australia, Newcastle, Australia, Gosford, Australia, Southport, Australia, Gold Coast, Australia, Callaghan, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRUCE R.","family":"KING","sequence":"additional","affiliation":[{"name":"New Lambton Heights, Australia, Newcastle, Australia, Gosford, Australia, Southport, Australia, Gold Coast, Australia, Callaghan, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/330-OR\/55330\/330-OR-A-30-Increased-Insulin-Dose-Is-Necessary-to","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/330-OR\/55330\/330-OR-A-30-Increased-Insulin-Dose-Is-Necessary-to","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:31:57Z","timestamp":1647163917000},"score":7.8179674,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/330-OR\/55330\/330-OR-A-30-Increased-Insulin-Dose-Is-Necessary-to"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-330-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"330-OR"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:23Z","timestamp":1753889843495,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Type 2 diabetes (T2D) is a major cause of morbidity and death worldwide. Women with gestational diabetes mellitus (GDM) have a seven-fold higher risk of developing T2D later in life. However, accurate methods for post-partum T2D risk stratification of GDM women, are lacking. MicroRNAs are now well recognised as circulating biomarkers or mediators of metabolic disease. We aimed to determine if post-partum circulating microRNAs can predict the devolvement of T2D in women with previous GDM. Participants were part of the GDM follow-up program at the Mercy Hospital for Women, Australia. Plasma samples were collected at 12-week post-partum from 103 women following an index GDM pregnancy. Women were followed for 10 years to assess development of T2D. In a discovery approach, we measured 754 miRNAs in plasma from T2D non-progressors (N=11) and in T2D progressors (N=10) using TaqMan-based real time PCR on an OpenArray platform. Data were analysed using penalised logistic regression followed by bootstrapping. Top 15 miRNAs with high frequencies in this discovery bootstrap analysis were selected for validation in the remaining samples (N=82; 71 non-progressors and 11 progressors). Validation data were normalized to spike-in control (ath-miR-172a). Four miRNAs (miR-543, miR-410, miR-491 and miR-369-3p) were significantly dysregulated (p&lt;0.05) between progressors and non-progressors to T2D, identifying these as risk factors. In a clinical model of prediction of T2D that included six traditional risk factors (age, BMI, pregnancy fasting glucose, post-OGTT change, cholesterol and triglycerides), the addition of these four circulating microRNA biomarkers measured at 12-weeks post-partum improved the prediction of future T2D from traditional AUC=0.8259 (95% CI: 0.68-0.9717) to an AUC= 0.9155 (95% CI: 0.8307-1). Replication of our findings in other cohorts is merited. Improved prediction will be beneficial in facilitating early intervention for T2D.<\/jats:p>\n \n Disclosure<\/jats:title>\n M. Joglekar: None. W.K. Wong: None. F. Ema: None. H.M. Georgiou: None. A. Hardikar: None. M. Lappas: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-94-or","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:38:49Z","timestamp":1592239129000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["94-OR: Postpartum Circulating MicroRNAs Can Predict the Development of Type 2 Diabetes in Women with Previous Gestational Diabetes"],"prefix":"10.2337","volume":"69","author":[{"given":"MUGDHA","family":"JOGLEKAR","sequence":"first","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WILSON K.","family":"WONG","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FAHMIDA KHAN","family":"EMA","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HARRY M.","family":"GEORGIOU","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANAND","family":"HARDIKAR","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTHA","family":"LAPPAS","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/94-OR\/56591\/94-OR-Postpartum-Circulating-MicroRNAs-Can-Predict","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/94-OR\/56591\/94-OR-Postpartum-Circulating-MicroRNAs-Can-Predict","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:34:43Z","timestamp":1647164083000},"score":7.8161826,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/94-OR\/56591\/94-OR-Postpartum-Circulating-MicroRNAs-Can-Predict"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-94-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"94-OR"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:35:55Z","timestamp":1753889755550,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: SGLT2i have major cardiorenal benefits for people with type 2 diabetes. While some guidelines recommend temporarily withholding SGLT2i during hospitalization, limited evidence suggests many people may not restart SGLT2i following discharge. We examined if hospitalization was a risk factor for SGLT2i discontinuation, and if this differed to other diabetes therapy (DPP-4i) not typically withheld in hospital.<\/jats:p>\n Methods: We conducted a retrospective cohort study using linked population level data for all adult residents of New South Wales, Australia. We included adults aged 40+ years initiating either SGLT2i or DPP-4i (separately) between 2016 to 2020 and followed up until the earliest: mid 2021 or death. We defined discontinuation as a period of 90 days without a dispensing. We used Cox proportional hazards models to estimate hazard ratios (HR) for the effect of recent hospitalization (within 90 days of discharge, as a time dependent variable) on discontinuation. Models were adjusted for demographic and clinical characteristics.<\/jats:p>\n Results: Of people initiating SGLT2i (n=106,098, median age 63 years, 61% male), 42.6% were hospitalized and 63.1% discontinued SGLT2i during follow-up. Discontinuation rates were higher in periods when people had recently been hospitalized (16.7 per 10,000 person-years) compared to periods with no hospitalization (10.1 per 10,000 person-years). This association remained in adjusted models (HR 1.63; 95% CI 1.59-1.66, p &lt;0.001). Of people initiating DPP-4i (n=91,960, median age 66 years, 57% male), 47.6% were hospitalized, and 64.0% discontinued DPP-4i during follow-up. Discontinuation rates were similarly higher around periods of hospitalization (adjusted HR 1.40, 95% CI 1.37-1.43, p &lt;0.001).<\/jats:p>\n Conclusion: Hospitalization is a risk factor for SGLT2i and DPP-4i discontinuation. Given their cardiorenal protection, our data should increase clinician awareness to ensure that SGLT2i and other critical medicines are not discontinued following hospitalization.<\/jats:p>\n \n Disclosure<\/jats:title>\n T.Y. Milder: None. L. Shepherd: Consultant; AbbVie Inc, IQVIA Inc. S. Pearson: None. H. R\u00e5ket: None. J. Greenfield: Other Relationship; Novo Nordisk. Speaker's Bureau; Novartis AG, Amgen Inc, Lilly Diabetes, Boehringer-Ingelheim. R.O. Day: None. J. Lin: None. C.A. Pollock: Speaker's Bureau; Amgen Inc. Advisory Panel; AstraZeneca. Speaker's Bureau; AstraZeneca, Boehringer-Ingelheim, CSL Behring. Advisory Panel; CSL Behring, Novo Nordisk A\/S. Speaker's Bureau; Novo Nordisk. B. Neuen: Consultant; AstraZeneca, Alexion Pharmaceuticals, Inc, Bayer Pharmaceuticals, Inc, Boehringer-Ingelheim, Novo Nordisk, Traveere Pharmaceuticals. Research Support; Menarini. M. Jun: Research Support; Boehringer Ingelheim and Eli Lilly Alliance. J. de Oliveira Costa: None. S. Stocker: Research Support; Gilead Sciences, Inc. Consultant; Nutromics Pty Ltd, Bellberry Pty Ltd, Virtus Health Pty Ltd, 23strands Pty Ltd. J. Ludington: None. M.O. Falster: Consultant; IQVIA Inc.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Health and Medical Research Council Ideas grant (grant number: 2002889); National Health and Medical Research Council Medicines Intelligence Centre of Research Excellence (1196900); National Heart Foundation of Australia Future Leader Fellowship (105609)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-904-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:07:37Z","timestamp":1749791257000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["904-P: Hospitalization Is a Risk Factor for SGLT2i Discontinuation"],"prefix":"10.2337","volume":"74","author":[{"given":"TAMARA Y.","family":"MILDER","sequence":"first","affiliation":[{"name":"Copenhagen NV, Denmark, Sydney, Australia, Darlinghurst, Australia, Kensington, Australia, Newtown, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEAH","family":"SHEPHERD","sequence":"additional","affiliation":[{"name":"Copenhagen NV, Denmark, Sydney, Australia, Darlinghurst, Australia, Kensington, Australia, Newtown, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SALLIE-ANNE","family":"PEARSON","sequence":"additional","affiliation":[{"name":"Copenhagen NV, Denmark, Sydney, Australia, Darlinghurst, Australia, Kensington, Australia, Newtown, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HANS","family":"KRISTIAN R\u00c5KET","sequence":"additional","affiliation":[{"name":"Copenhagen NV, Denmark, Sydney, Australia, Darlinghurst, Australia, Kensington, Australia, Newtown, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JERRY","family":"GREENFIELD","sequence":"additional","affiliation":[{"name":"Copenhagen NV, Denmark, Sydney, Australia, Darlinghurst, Australia, Kensington, Australia, Newtown, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD O.","family":"DAY","sequence":"additional","affiliation":[{"name":"Copenhagen NV, Denmark, Sydney, Australia, Darlinghurst, Australia, Kensington, Australia, Newtown, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIALING","family":"LIN","sequence":"additional","affiliation":[{"name":"Copenhagen NV, Denmark, Sydney, Australia, Darlinghurst, Australia, Kensington, Australia, Newtown, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CAROL A.","family":"POLLOCK","sequence":"additional","affiliation":[{"name":"Copenhagen NV, Denmark, Sydney, Australia, Darlinghurst, Australia, Kensington, Australia, Newtown, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRENDON","family":"NEUEN","sequence":"additional","affiliation":[{"name":"Copenhagen NV, Denmark, Sydney, Australia, Darlinghurst, Australia, Kensington, Australia, Newtown, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIN","family":"JUN","sequence":"additional","affiliation":[{"name":"Copenhagen NV, Denmark, Sydney, Australia, Darlinghurst, Australia, Kensington, Australia, Newtown, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JULIANA","family":"DE OLIVEIRA COSTA","sequence":"additional","affiliation":[{"name":"Copenhagen NV, Denmark, Sydney, Australia, Darlinghurst, Australia, Kensington, Australia, Newtown, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SOPHIE","family":"STOCKER","sequence":"additional","affiliation":[{"name":"Copenhagen NV, Denmark, Sydney, Australia, Darlinghurst, Australia, Kensington, Australia, Newtown, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANE","family":"LUDINGTON","sequence":"additional","affiliation":[{"name":"Copenhagen NV, Denmark, Sydney, Australia, Darlinghurst, Australia, Kensington, Australia, Newtown, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL O.","family":"FALSTER","sequence":"additional","affiliation":[{"name":"Copenhagen NV, Denmark, Sydney, Australia, Darlinghurst, Australia, Kensington, Australia, Newtown, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/904-P\/158431\/904-P-Hospitalization-Is-a-Risk-Factor-for-SGLT2i","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/904-P\/158431\/904-P-Hospitalization-Is-a-Risk-Factor-for-SGLT2i","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T15:37:08Z","timestamp":1750433828000},"score":7.8158803,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/904-P\/158431\/904-P-Hospitalization-Is-a-Risk-Factor-for-SGLT2i"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-904-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"904-P"},{"indexed":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T05:16:05Z","timestamp":1678511765054},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Supplement 4","content-domain":{"domain":["www.auajournals.org"],"crossmark-restriction":true},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1097\/01.ju.0000555138.43594.e0","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T05:40:57Z","timestamp":1556084457000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["MP09-14\u2003HYBRID PSMA PET\/MRI FOR PRIMARY STAGING IN PRESUMED LOCALISED PROSTATE CANCER: A CONTEMPORARY, TERTIARY HOSPITAL SERIES"],"prefix":"10.1097","volume":"201","author":[{"given":"Georges","family":"Mehawed*","sequence":"first","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paria","family":"Saadat","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Ong","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Joshi","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Roberts","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlon","family":"Perera","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handoo","family":"Rhee","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Yeates","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janelle","family":"Munns","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Malone","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Chung","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Heathcote","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Preston","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Lawson","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Wood","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Gustafson","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Miles","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Ngai","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Vela","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"http:\/\/www.auajournals.org\/doi\/pdf\/10.1097\/01.JU.0000555138.43594.e0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T16:06:58Z","timestamp":1678464418000},"score":7.815584,"resource":{"primary":{"URL":"http:\/\/www.auajournals.org\/doi\/10.1097\/01.JU.0000555138.43594.e0"}},"issued":{"date-parts":[[2019,4]]},"references-count":0,"journal-issue":{"issue":"Supplement 4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1097\/01.JU.0000555138.43594.e0"],"URL":"https:\/\/doi.org\/10.1097\/01.ju.0000555138.43594.e0","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"2019-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:29:53Z","timestamp":1780471793918,"version":"3.54.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Introduction: Type 1 diabetes guidelines recommend that mealtime insulin dosing accounts for fat and protein. However, implementation remains a challenge.<\/jats:p>\n Aim: To evaluate an individual\u2019s glycemic response to a high fat, high protein meal (HFHP) and develop a personalized \u2018metabolic digital twin\u2019 (MDTwin) capable of predicting an optimal insulin dose and delivery pattern which accounts for meal fat and protein.<\/jats:p>\n Method: Participants (n=9) using pump therapy; mean age 13.9 \u00b13.2 years (5 male), T1D duration 4.8 \u00b13.8 years, and HbA1c 49 mmol\/mol (6.7 \u00b10.6%) wore Dexcom G5 CGMS and were given an insulin dual wave bolus (insulin to carbohydrate ratio [ICR] x1, ICRx1.2, ICRx1.4 or ICRx1.6) and ate a HFHP (C:30g, F:40g, P:50g) on 4 mornings. Individual MDTwins were fitted by System Identification methodology combined with a statistical quantification using the ICRx1 and ICRx1.6 CGMS traces. MDTwins were validated using the ICRx1.2 and ICRx1.4 traces.<\/jats:p>\n Results: The MDTwins identified individual insulin and distribution requirements to achieve optimal postprandial glycemic control (Figure). MDTwins identified marked inter-individual variability in insulin dose and distribution requirements.<\/jats:p>\n Conclusion: MDTwins can potentially be used to inform and individualize insulin dosing strategies for meal fat and protein to produce optimal glycemic outcomes. Further research is required.<\/jats:p>\n \n Disclosure<\/jats:title>\n T.A. Smith: None. M.M. Seron: None. G.C. Goodwin: None. A.M. Medioli: None. B.R. King: None. C.E. Smart: None. M. Harris: None. D.N. ONeal: None. J. Rafferty: None. P. Howley: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Diabetes Australia<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-1058-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:30:30Z","timestamp":1559694630000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":5,"title":["1058-P: The Use of Metabolic Digital Twins to Personalize Mealtime Insulin Dosing in Type 1 Diabetes Clinical Management"],"prefix":"10.2337","volume":"68","author":[{"given":"TENELE A.","family":"SMITH","sequence":"first","affiliation":[{"name":"Newcastle, Australia, Callaghan, Australia, Sydney, Australia, Brisbane, Australia, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIA M.","family":"SERON","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Callaghan, Australia, Sydney, Australia, Brisbane, Australia, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GRAHAM C.","family":"GOODWIN","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Callaghan, Australia, Sydney, Australia, Brisbane, Australia, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ADRIAN M.","family":"MEDIOLI","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Callaghan, Australia, Sydney, Australia, Brisbane, Australia, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BRUCE R.","family":"KING","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Callaghan, Australia, Sydney, Australia, Brisbane, Australia, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CARMEL E.","family":"SMART","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Callaghan, Australia, Sydney, Australia, Brisbane, Australia, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARK","family":"HARRIS","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Callaghan, Australia, Sydney, Australia, Brisbane, Australia, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVID N.","family":"ONEAL","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Callaghan, Australia, Sydney, Australia, Brisbane, Australia, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JORDAN","family":"RAFFERTY","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Callaghan, Australia, Sydney, Australia, Brisbane, Australia, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PETER","family":"HOWLEY","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Callaghan, Australia, Sydney, Australia, Brisbane, Australia, Fitzroy, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1058-P\/58902\/1058-P-The-Use-of-Metabolic-Digital-Twins-to","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1058-P\/58902\/1058-P-The-Use-of-Metabolic-Digital-Twins-to","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:55:42Z","timestamp":1647165342000},"score":7.814211,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1058-P\/58902\/1058-P-The-Use-of-Metabolic-Digital-Twins-to"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-1058-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"1058-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:39:30Z","timestamp":1753889970267,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Exosomes are membrane-bound extracellular vesicles secreted from a range of cells including human placental cells and contain specific cargo such as proteins, and miRNAs. The aim of this study was to determine the miRNA and protein profile in primary human trophoblast (PTH) and their secreted exosomes obtained from placentae from women with normal glucose tolerant (NGT) and gestational diabetes mellitus (GDM). Using quantitative proteomic analysis, 34 proteins were significantly different in PTH from GDM compared with NGT. Similarly, a specific set of proteins were significantly different in PTH exosomes from GDM compared with NGT. An Illumina TrueSeq Small RNA kit was used to construct a small RNA library from PTH and exosomes. We identified a set of miRNAs (miR-181, miR-151, miR-10a, miR-744, miR-1468 and miR-4507) which their expression varied in a consistent pattern in PTH and their secreted exosomes in GDM compared with NGT. Interestingly, a specific set of proteins and miRNAs were selectively enriched with exosomes and compared with their PTH of origin in NGT and GDM indicating a specific packaging of proteins and miRNAs into exosomes. We used Ingenuity Pathway Analysis (IPA) analysis to identify miRNA-gene interactions using the miRNA and proteomic data and created a network link with the down- and up-regulated pairs of miRNA-proteins. IPA core analysis showed that the top canonical pathway associated with these miRNAs were PI3\/AKT signalling and glucose metabolism\/insulin resistance, respectively. We proposed that exosomes are \u201cfingerprints\u201d of the releasing cells and their metabolic status. Exosomes released from placenta can modify the phenotype of target cells, inducing metabolic changes in GDM to contribute to changes in insulin sensitivity during pregnancy.<\/jats:p>\n \n Disclosure<\/jats:title>\n S. Nair: None. N. Jayabalan: None. D. Guanzon: None. A. Lai: None. D. McIntyre: Other Relationship; Self; Novo Nordisk A\/S. M. Lappas: None. C. Salomon: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Diabetes Australia; Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico (1170809)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-96-or","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:38:49Z","timestamp":1592239129000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["96-OR: Integrative Omics Analysis Revealed That the Metabolic Changes in Placental Cells from Gestational Diabetes Mellitus Are Reflected in Their Secreted Exosomes"],"prefix":"10.2337","volume":"69","author":[{"given":"SOUMYALEKSHMI","family":"NAIR","sequence":"first","affiliation":[{"name":"Brisbane, Australia, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NANTHINI","family":"JAYABALAN","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATHERIN","family":"SCHOLZ-ROMERO","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DOMINIC","family":"GUANZON","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREW","family":"LAI","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"MCINTYRE","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTHA","family":"LAPPAS","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARLOS","family":"SALOMON","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/96-OR\/56602\/96-OR-Integrative-Omics-Analysis-Revealed-That-the","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/96-OR\/56602\/96-OR-Integrative-Omics-Analysis-Revealed-That-the","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:34:48Z","timestamp":1647164088000},"score":7.811393,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/96-OR\/56602\/96-OR-Integrative-Omics-Analysis-Revealed-That-the"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-96-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"96-OR"},{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:42:12Z","timestamp":1759178532793,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Background: Few long-term RCTs compare Hybrid Closed Loop (HCL) insulin delivery to manual (non-HCL) insulin dosing in type 1 diabetes (T1D).<\/jats:p>\n Objective: To examine glycemic and psychosocial outcomes in adults with T1D using HCL vs. manual insulin dosing with self-monitoring of blood glucose (SMBG) for 6 months.<\/jats:p>\n Methods: Adults using multiple daily injections or pumps with SMBG were randomized 1:1 after insulin dose optimization to 26 weeks of HCL (Medtronic 670G) or continuation of current therapy. The primary outcome was time in target range (70-180mg\/dL) with masked CGM during the final 3 weeks. Secondary outcomes included other CGM metrics, HbA1c, treatment satisfaction (DTSQs) and diabetes distress (PAID). Intention to treat analysis was performed with ANCOVA or rank sum test.<\/jats:p>\n Results: HCL and control groups were well balanced at baseline (Table). At 26 weeks, mean (95% CI) CGM time in range with HCL was greater by 14.8% (11.1, 18.5), with reduced high and low glucose time, and lower HbA1c. There were no between-group differences in treatment satisfaction or diabetes distress (Table).<\/jats:p>\n Conclusions: HCL provided a significant and sustained glycemic benefit compared with standard therapy. Results will inform potential users and health professionals and a cost-benefit analysis may facilitate HCL access.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n S.A. McAuley: Advisory Panel; Self; Medtronic. Research Support; Self; Medtronic, Roche Diabetes Care. Speaker\u2019s Bureau; Self; Lilly Diabetes, Roche Diabetes Care. M.H. Lee: Research Support; Self; Medtronic. Speaker\u2019s Bureau; Self; AstraZeneca, Medtronic. B. Paldus: Research Support; Self; JDRF. Speaker\u2019s Bureau; Self; Australian Diabetes Society, Medtronic. S. Vogrin: None. M.B. Abraham: Speaker\u2019s Bureau; Self; Lilly Diabetes. L. Bach: None. M. Burt: None. N. Cohen: Advisory Panel; Self; Abbott, AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Lilly Diabetes. Research Support; Self; Ypsomed AG. Speaker\u2019s Bureau; Self; Novo Nordisk A\/S. P.G. Colman: None. E.A. Davis: None. C. Hendrieckx: None. M. de Bock: None. J. Holmes-Walker: None. J. Kaye: Advisory Panel; Self; Abbott. Speaker\u2019s Bureau; Self; AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Novo Nordisk Inc. K. Kumareswaran: None. R. MacIsaac: None. R.W. McCallum: None. C.M. Sims: Stock\/Shareholder; Self; Medtronic. J. Speight: Research Support; Self; Abbott, AstraZeneca, Medtronic, Sanofi-Aventis. Speaker\u2019s Bureau; Self; American Diabetes Association, Australian Diabetes Society, Roche Diabetes Care. S. Stranks: Advisory Panel; Self; AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Lilly Diabetes, Sanofi-Aventis. S. Trawley: None. V. Sundararajan: None. G. Ward: None. A.C. Keech: Advisory Panel; Self; Amgen, Kowa Research Institute, Inc. Consultant; Self; Sanofi-Aventis. Speaker\u2019s Bureau; Self; Abbott, Amgen. A. Jenkins: Advisory Panel; Self; Abbott, Medtronic. Research Support; Self; Abbott, GlySens Incorporated, Medtronic, Sanofi-Aventis. T. Jones: Other Relationship; Self; Medtronic. D.N. ONeal: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-999-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:38:49Z","timestamp":1592239129000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":6,"title":["999-P: Six Months At-Home Hybrid Closed-Loop vs. Manual Insulin Delivery with Finger-Stick Blood Glucose Monitoring in Adults with Type 1 Diabetes: A Randomized Controlled Trial"],"prefix":"10.2337","volume":"69","author":[{"given":"SYBIL A.","family":"MCAULEY","sequence":"first","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MELISSA H.","family":"LEE","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BARBORA","family":"PALDUS","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SARA","family":"VOGRIN","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARY B.","family":"ABRAHAM","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEON","family":"BACH","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MORTON","family":"BURT","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NEALE","family":"COHEN","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER G.","family":"COLMAN","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH A.","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTEL","family":"HENDRIECKX","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTIN DE","family":"BOCK","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANE","family":"HOLMES-WALKER","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOEY","family":"KAYE","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAVITA","family":"KUMARESWARAN","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"MACISAAC","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROLAND W.","family":"MCCALLUM","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CATRIONA M.","family":"SIMS","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANE","family":"SPEIGHT","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN","family":"STRANKS","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEVEN","family":"TRAWLEY","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VIJAYA","family":"SUNDARARAJAN","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GLENN","family":"WARD","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTHONY C.","family":"KEECH","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIM","family":"JONES","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"ONEAL","sequence":"additional","affiliation":[{"name":"Perth, Australia, Adelaide, Australia, Parkville, Australia, Christchurch, New Zealand, Westmead, Australia, Melbourne, Australia, Hobart, Australia, Fitzroy, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/999-P\/56713\/999-P-Six-Months-At-Home-Hybrid-Closed-Loop-vs","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/999-P\/56713\/999-P-Six-Months-At-Home-Hybrid-Closed-Loop-vs","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:35:45Z","timestamp":1647164145000},"score":7.8089185,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/999-P\/56713\/999-P-Six-Months-At-Home-Hybrid-Closed-Loop-vs"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-999-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"999-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:28Z","timestamp":1753890028512,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Introduction: Reviewing rCGM patterns may prompt lifestyle or therapeutic changes to achieve glycaemic targets but evidence for rCGM use in primary care management of T2D is limited.<\/jats:p>\n Methods: Two-arm RCT. Participants: Adults with T2D, HbA1c \u22650.5% above target, prescribed \u22652 non-insulin glycemia medications or insulin. Intervention: 1-hour diabetes education and (at 0\/3\/6\/9\/12 months): HbA1c assessment + wearing FreeStyle Libre Pro (Abbott) for up to 14 days prior to being discussed at a clinic visit. Physicians were trained in interpreting ambulatory glucose profiles. Control: 3-monthly \u2018usual care\u2019 clinic visits + r-CGM device worn (blinded, research data) at 0 and 12 months. Primary outcome: difference in mean HbA1c at 12 months. Secondary outcomes: mean differences in time in range (TIR: 4-10 mmol\/L) and diabetes-specific distress (PAID) at 12 months, and HbA1c at 6 months. ITT analysis.<\/jats:p>\n Results: In 25 primary care practices, participants were: 299 adults with T2D, aged (mean(SD)) 60(10) years, HbA1c: 8.9(1.2)%, diabetes duration (median(IQR)) of 12(8,20) years. At 12 months, the between-group difference in mean HbA1c was 0.2% (p=0.112). The estimated mean percentage TIR was 8.4% higher in the intervention than the control arm (p=0.004). Diabetes-specific distress did not differ between arms (0.5; p=0.71). At 6 months, HbA1c was significantly lower in the intervention arm (0.5%; p&lt;0.001). We found little evidence of changes in the number of glycemic medications in either arm.<\/jats:p>\n Discussion: Use of 3-monthly rCGM in adults with T2D in primary care does not improve HbA1c at 12 months. We showed a statistically and clinically significant reduction in HbA1c at 6 months in the intervention group, as well as significant improvements in TIR at 12 months, with no change in diabetes distress. Our findings suggest the primary impact of r-CGM use on HbA1c in this setting is short term, and not associated with increase in the number of diabetes medications.<\/jats:p>\n \n Disclosure<\/jats:title>\n J. Furler: Research Support; Self; Abbott, Sanofi. D.N. O\u2019Neal: None. J. Speight: Research Support; Self; AstraZeneca, Medtronic, Sanofi. Speaker\u2019s Bureau; Self; Novo Nordisk A\/S, Roche Diabetes Care. J.E. Manski-Nankervis: Research Support; Self; Australian National Health and Medical Research Council, Boehringer Ingelheim International GmbH, Diabetes Australia, Eli Lilly and Company. Speaker\u2019s Bureau; Self; RACGP. S. Thuraisingam: None. E. Holmes-Truscott: Research Support; Self; Sanofi. Speaker\u2019s Bureau; Self; Novo Nordisk Inc. K.R. De La Rue: None. L.E. Ginnivan: None. R.C. Doyle: None. K. Khunti: Advisory Panel; Self; Amgen Inc., AstraZeneca, Eli Lilly and Company, Merck Sharp & Dohme Corp., Novo Nordisk A\/S, Sanofi. Consultant; Self; AstraZeneca, Boehringer Ingelheim International GmbH, Eli Lilly and Company, Janssen Pharmaceuticals, Inc., Merck Sharp & Dohme Corp., Novartis AG, Novo Nordisk A\/S, Pfizer Inc., Sanofi-Aventis, Servier, Takeda Pharmaceutical Company Limited. Research Support; Self; AstraZeneca, Boehringer Ingelheim International GmbH, Eli Lilly and Company, Merck Sharp & Dohme Corp., Novartis AG, Novo Nordisk A\/S, Pfizer Inc., Sanofi-Aventis. Speaker\u2019s Bureau; Self; AstraZeneca, Berlin-Chemie AG, Boehringer Ingelheim International GmbH, Eli Lilly and Company, Janssen Pharmaceuticals, Inc., Menarini Group, Merck Sharp & Dohme Corp., Novartis AG, Novo Nordisk A\/S, Roche Pharma, Sanofi, Servier, Takeda Pharmaceutical Company Limited. M. Catchpool: None. K. Dalziel: None. J.I. Chiang: None. I. Blackberry: None. R. Audehm: Advisory Panel; Self; AstraZeneca, Novartis Pharmaceuticals Corporation. M. Kennedy: Advisory Panel; Self; AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Merck Sharp & Dohme Corp., Novo Nordisk Inc., Sanofi. M.J. Clark: None. A.J. Jenkins: Advisory Panel; Self; Abbott, Australian Diabetes Society, Medtronic. Research Support; Self; Abbott, GlySens Incorporated, Medtronic, Mylan. Speaker\u2019s Bureau; Self; Eli Lilly and Company, Novo Nordisk Inc. A.S. Januszewski: None. D. Liew: Advisory Panel; Self; AstraZeneca, Bayer AG. Research Support; Self; AbbVie Inc., AstraZeneca, Bristol-Myers Squibb Company, CSL Behring, Pfizer Inc. P.M. Clarke: None. J.D. Best: Consultant; Self; Abbott.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Health and Medical Research Council of Australia (APP1104241); Sanofi Australia; Abbott Diabetes Care<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-102-lb","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:28:10Z","timestamp":1559694490000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["102-LB: GP-OSMOTIC: An RCT to Determine the Effect of 3-Monthly Retrospective Continuous Glucose Monitoring (rCGM) on 12-Month HbA1c in Adults with Type 2 Diabetes (T2D) in Primary Care"],"prefix":"10.2337","volume":"68","author":[{"given":"JOHN","family":"FURLER","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O\u2019NEAL","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANE","family":"SPEIGHT","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JO-ANNE E.","family":"MANSKI-NANKERVIS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHARMALA","family":"THURAISINGAM","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH","family":"HOLMES-TRUSCOTT","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATIE R.","family":"DE LA RUE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LOUISE E.","family":"GINNIVAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"REBECCA C.","family":"DOYLE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAMLESH","family":"KHUNTI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAX","family":"CATCHPOOL","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KIM","family":"DALZIEL","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JASON I.","family":"CHIANG","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IRENE","family":"BLACKBERRY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RALPH","family":"AUDEHM","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK","family":"KENNEDY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MALCOLM J.","family":"CLARK","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA J.","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DANNY","family":"LIEW","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PHILIP M.","family":"CLARKE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAMES D.","family":"BEST","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia, Carlton, Australia, Geelong, Australia, Leicester, United Kingdom, Wodonga, Australia, Clayton, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/102-LB\/58796\/102-LB-GP-OSMOTIC-An-RCT-to-Determine-the-Effect","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/102-LB\/58796\/102-LB-GP-OSMOTIC-An-RCT-to-Determine-the-Effect","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:54:48Z","timestamp":1647165288000},"score":7.8088326,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/102-LB\/58796\/102-LB-GP-OSMOTIC-An-RCT-to-Determine-the-Effect"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-102-lb","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"102-LB"},{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:43:48Z","timestamp":1768693428935,"version":"3.49.0"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,6,14]]},"abstract":"Context: Individuals with diabetes frequently encounter sleep disturbances, which can detrimentally impact glycemic management. We review the relationship between sleep and glycemic variability in adults with diabetes.<\/jats:p>\n Methods: We systematically searched Medline, EMBASE, and Cochrane Library (2002-March 2023) for studies evaluating sleep and glycemic variability metrics in adults with type 1 and type 2 diabetes.<\/jats:p>\n Results: Among 3,049 records, 26 met inclusion criteria (type 1 diabetes studies=21). Due to methodological heterogeneity, a qualitative analysis was conducted. Most studies measuring sleep quality (5 out 7; 71%) reported a significant association with glycemic variability in type 1 and type 2 diabetes. In type 1 diabetes, sleep duration showed no significant association with glycemic variability, while other sleep metrics yielded inconclusive results. Hybrid closed-loop pump interventions (n=12) demonstrated varying sleep outcomes but consistently improved glycemic variability. Conversely, sleep interventions (n=3) enhanced sleep but not glycemic variability. Limitations included moderate to high-risk of study bias, confounders, methodological heterogeneity, and limited type 2 diabetes data.<\/jats:p>\n Conclusion: A potential association between sleep quality and glycemic variability exists. However, associations with other sleep metrics remain elusive, with no discernible association between sleep duration and glycemic variability in type 1 diabetes. Despite advancements in continuous glucose monitoring and ambulatory sleep monitoring, standardized sleep assessment methodologies are lacking in real-world research. Establishing standard protocols for sleep assessment and defining optimal sleep targets is crucial for meaningful comparisons between studies. Understanding the complex interplay between sleep and glycemic variability holds promise for improving diabetes management and sleep health.<\/jats:p>\n \n Disclosure<\/jats:title>\n C.T. Pham: Research Support; Eli Lilly and Company, Boehringer-Ingelheim, Sanofi, Novo Nordisk, Versanis, Endogenex. A. Ali: None. L. Churilov: None. S. Baqar: None. C. Hendrieckx: None. D.N. O'Neal: None. M.E. Howard: None. E.I. Ekinci: Advisory Panel; Lilly Diabetes. Research Support; Novo Nordisk, Boehringer-Ingelheim, Eli Lilly and Company. Board Member; Eli Lilly and Company. Advisory Panel; Abbott. Research Support; Endogenex, Versanis, AstraZeneca.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db24-683-p","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T05:27:00Z","timestamp":1718342820000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":2,"title":["683-P: Association between Glycaemic Variability and Sleep in Adults with Type 1 and Type 2 Diabetes\u2014A Systematic Review"],"prefix":"10.2337","volume":"73","author":[{"given":"CECILIA T.","family":"PHAM","sequence":"first","affiliation":[{"name":"Parkville, Australia, Clayton, Australia, Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALEENA","family":"ALI","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Clayton, Australia, Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEONID","family":"CHURILOV","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Clayton, Australia, Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SARA","family":"BAQAR","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Clayton, Australia, Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTEL","family":"HENDRIECKX","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Clayton, Australia, Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Clayton, Australia, Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK E.","family":"HOWARD","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Clayton, Australia, Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIF I.","family":"EKINCI","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Clayton, Australia, Melbourne, Australia, Fitzroy, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/683-P\/155341\/683-P-Association-between-Glycaemic-Variability","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/683-P\/155341\/683-P-Association-between-Glycaemic-Variability","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T05:27:00Z","timestamp":1718342820000},"score":7.806281,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/683-P\/155341\/683-P-Association-between-Glycaemic-Variability"}},"issued":{"date-parts":[[2024,6,14]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2024,6,14]]}},"URL":"https:\/\/doi.org\/10.2337\/db24-683-p","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2024,6,14]]},"article-number":"683-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:41:39Z","timestamp":1753890099113,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"Aim: To compare neonatal outcomes between women with early GDM (eGDM: diagnosed&lt;20 weeks\u2019 gestation), incident GDM (iGDM: diagnosed \u2265 24 weeks\u2019 gestation) and normoglycemia<\/jats:p>\n Methods: Pregnant women with GDM risk factors were enrolled &lt;20 weeks\u2019 gestation into an eGDM treatment trial across 17 sites in Australia, India, Europe. Women undertook a 2-h 75g oral glucose tolerance test on entry & at 24-28 weeks\u2019 gestation. GDM was defined by WHO 2013 criteria. Logistic regression compared outcomes between women with eGDM, iGDM and normoglycemia adjusted for age, body mass index (BMI), site, smoking status, parity and tertiary qualifications. Women randomized to receive eGDM treatment were excluded from this analysis.<\/jats:p>\n Results: Baseline characteristics differed by age, BMI, parity and glycemia across the 3211 women (Table 1). Similar proportions of eGDM and iGDM women received pharmacotherapy. eGDM group gestational weight gain was lower; eGDM and iGDM neonatal outcomes were similar; neonatal intensive care unit admission and respiratory distress were higher in offspring of eGDM than normoglycemic women.<\/jats:p>\n Conclusions: Adverse neonatal outcomes are increased in pregnancies complicated by eGDM with delayed treatment.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n D.Simmons: Consultant; Sanofi, Speaker's Bureau; Abbott Diabetes. M.Mclean: None. A.Sweeting: None. V.Mohan: None. J.Harreiter: None. Tobogm core investigator group: n\/a. J.Immanuel: None. N.Cheung: None. W.Hague: None. H.Teede: None. C.J.Nolan: None. H.E.Backman: None. E.Hibbert: None. M.J.Peek: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Health and Medical Research Council (1104231, 2009326); Region \u00d6rebro Research Committee (OLL-970566, OLL-942177); Medical Scientific Fund of the Mayor of Vienna (15205); South Western Sydney Local Health District Academic Unit (2016); Western Sydney University Ainsworth Trust (2019)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-281-or","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:25:02Z","timestamp":1687238702000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["281-OR: Neonatal Outcomes in Early and Incident Gestational Diabetes Mellitus\u2014Are They Normalized with Treatment from 24\u201328 Weeks\u2019 Gestation?"],"prefix":"10.2337","volume":"72","author":[{"given":"DAVID","family":"SIMMONS","sequence":"first","affiliation":[{"name":"Campbelltown, Australia, North Adelaide, Australia, Melbourne, Australia, Woden, Australia, Orebro, Sweden, Kingswood, Australia, Canberra, Australia, Westmead, Australia, Sydney, Australia, Chennai, India, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JINCY","family":"IMMANUEL","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, North Adelaide, Australia, Melbourne, Australia, Woden, Australia, Orebro, Sweden, Kingswood, Australia, Canberra, Australia, Westmead, Australia, Sydney, Australia, Chennai, India, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"WAH CHEUNG","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, North Adelaide, Australia, Melbourne, Australia, Woden, Australia, Orebro, Sweden, Kingswood, Australia, Canberra, Australia, Westmead, Australia, Sydney, Australia, Chennai, India, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WILLIAM","family":"HAGUE","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, North Adelaide, Australia, Melbourne, Australia, Woden, Australia, Orebro, Sweden, Kingswood, Australia, Canberra, Australia, Westmead, Australia, Sydney, Australia, Chennai, India, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HELENA","family":"TEEDE","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, North Adelaide, Australia, Melbourne, Australia, Woden, Australia, Orebro, Sweden, Kingswood, Australia, Canberra, Australia, Westmead, Australia, Sydney, Australia, Chennai, India, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTOPHER J.","family":"NOLAN","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, North Adelaide, Australia, Melbourne, Australia, Woden, Australia, Orebro, Sweden, Kingswood, Australia, Canberra, Australia, Westmead, Australia, Sydney, Australia, Chennai, India, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HELENA E.","family":"BACKMAN","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, North Adelaide, Australia, Melbourne, Australia, Woden, Australia, Orebro, Sweden, Kingswood, Australia, Canberra, Australia, Westmead, Australia, Sydney, Australia, Chennai, India, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EMILY","family":"HIBBERT","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, North Adelaide, Australia, Melbourne, Australia, Woden, Australia, Orebro, Sweden, Kingswood, Australia, Canberra, Australia, Westmead, Australia, Sydney, Australia, Chennai, India, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL J.","family":"PEEK","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, North Adelaide, Australia, Melbourne, Australia, Woden, Australia, Orebro, Sweden, Kingswood, Australia, Canberra, Australia, Westmead, Australia, Sydney, Australia, Chennai, India, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK","family":"MCLEAN","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, North Adelaide, Australia, Melbourne, Australia, Woden, Australia, Orebro, Sweden, Kingswood, Australia, Canberra, Australia, Westmead, Australia, Sydney, Australia, Chennai, India, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ARIANNE","family":"SWEETING","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, North Adelaide, Australia, Melbourne, Australia, Woden, Australia, Orebro, Sweden, Kingswood, Australia, Canberra, Australia, Westmead, Australia, Sydney, Australia, Chennai, India, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VISWANATHAN","family":"MOHAN","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, North Adelaide, Australia, Melbourne, Australia, Woden, Australia, Orebro, Sweden, Kingswood, Australia, Canberra, Australia, Westmead, Australia, Sydney, Australia, Chennai, India, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00dcRGEN","family":"HARREITER","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, North Adelaide, Australia, Melbourne, Australia, Woden, Australia, Orebro, Sweden, Kingswood, Australia, Canberra, Australia, Westmead, Australia, Sydney, Australia, Chennai, India, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"TOBOGM CORE INVESTIGATOR GROUP","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/281-OR\/149531\/281-OR-Neonatal-Outcomes-in-Early-and-Incident","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/281-OR\/149531\/281-OR-Neonatal-Outcomes-in-Early-and-Incident","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:25:02Z","timestamp":1687238702000},"score":7.805814,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/281-OR\/149531\/281-OR-Neonatal-Outcomes-in-Early-and-Incident"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-281-or","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"281-OR"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:16Z","timestamp":1753889836733,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Young adult onset type 2 diabetes (YT2DM) is an aggressive disease. Cross-sectional studies have shown a higher prevalence of albuminuria in YT2DM compared to age-matched young adults with T1DM (YT1DM). Whether this translates to poorer long-term renal outcomes has not been widely studied. We aimed (i) to examine progression to renal replacement therapy (RRT) and renal-related death (RRD) in our young adult population, and (ii) to examine survival on RRT for those individuals who reached end stage renal disease. We performed probabilistic linkage of prospectively collected data from the RPA Diabetes Centre eMR to the Australian National Death Index and the Australian and New Zealand Dialysis and Transplant Registry up to 31\/12\/2015. In our patient cohort diagnosed between the ages of 15 and 35 years, 1,248 had YT1DM and 1,534 had YT2DM. After a median (IQR) observation of 13.6 (6.9-20.7) years, 56 (4.5%) of YT1DM vs. 98 (6.4%) of YT2DM reached the combined renal end-point of RRT\/RRD. Analysis of Kaplan-Meier survival curves demonstrated a greater rate of progression of renal disease in YT2DM (Log-rank p=0.003). Cox proportional hazard modelling of RRT\/RRD with adjustment for gender, ethnicity and duration of diabetes exposure was undertaken. The HR (95% CI) for an adverse renal outcome in YT2DM relative to YT1DM was 2.0 (1.4-2.9), p&lt;0.001. This HR was attenuated when further adjustments were made for HbA1c, blood pressure, BMI and cholesterol. Similar results were obtained after multiple imputation for missing data. For the 80 young adults who commenced RRT, there were 19 deaths (70%) in the YT1DM subgroup and 26 deaths (49%) in the YT2DM subgroup after a median (IQR) observation time of 4.2 (2.2-9.1) years. KM survival analysis demonstrated equally poor survival in YT1DM and YT2DM. Cox regression with transplant as a time-varying covariate also showed non-significance. These data highlight the more rapidly progressive renal disease seen in YT2DM compared to YT1DM; however, survival on RRT appears to be equally poor for both diabetes types.<\/jats:p>\n \n Disclosure<\/jats:title>\n T. Middleton: Other Relationship; Self; AstraZeneca. S. Chadban: None. L.M. Molyneaux: None. M.I. D'Souza: None. M.I. Constantino: None. D. Yue: None. M. McGill: None. T. Wu: Advisory Panel; Self; Boehringer Ingelheim International GmbH, Eli Lilly and Company, Novo Nordisk A\/S, Sanofi. Speaker's Bureau; Self; AstraZeneca, Boehringer Ingelheim International GmbH, Eli Lilly and Company, Merck Sharp & Dohme Corp., Novo Nordisk A\/S, Sanofi. S.M. Twigg: Advisory Panel; Self; Abbott, Boehringer Ingelheim Pharmaceuticals, Inc., Novo Nordisk Inc., Sanofi-Aventis. Board Member; Self; AstraZeneca. Research Support; Self; Abbott. Speaker's Bureau; Self; Abbott, AstraZeneca, Merck Sharp & Dohme Corp., Novo Nordisk Inc., Sanofi-Aventis. J. Wong: Advisory Panel; Self; Sanofi. Speaker's Bureau; Self; AstraZeneca, Lilly Diabetes.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-522-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T03:06:15Z","timestamp":1559703975000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["522-P: Long-Term Renal Outcomes in Young Onset Type 2 Diabetes"],"prefix":"10.2337","volume":"68","author":[{"given":"TIMOTHY","family":"MIDDLETON","sequence":"first","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEVE","family":"CHADBAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"SR.","given":"LYNDA M.","family":"MOLYNEAUX","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIO I.","family":"D'SOUZA","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA I.","family":"CONSTANTINO","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DENNIS","family":"YUE","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARGARET","family":"MCGILL","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TED","family":"WU","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN M.","family":"TWIGG","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENCIA","family":"WONG","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/522-P\/60633\/522-P-Long-Term-Renal-Outcomes-in-Young-Onset-Type","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/522-P\/60633\/522-P-Long-Term-Renal-Outcomes-in-Young-Onset-Type","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:14:25Z","timestamp":1647166465000},"score":7.805798,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/522-P\/60633\/522-P-Long-Term-Renal-Outcomes-in-Young-Onset-Type"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-522-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"522-P"},{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:39:59Z","timestamp":1772152799706,"version":"3.50.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Previously we introduced furin-cleavable human insulin (INSFUR) to the livers in several animal models using a lentiviral vector. Reversal of diabetes with normal glucose tolerance and pancreatic transdifferentiation was seen. The aim of the present study was to ascertain if we could similarly reverse diabetes in the non-obese diabetic (NOD) mouse using a clinically-applicable AAV system to deliver INSFUR \u00b1 the \u03b2-cell transcription factor (TF) Pdx1 to the livers of the diabetic mice. The traditional AAV8 that allows predominantly episomal expression, and the hybrid AAV8\/piggyBac that results in transgene integration into the host genome were used. Weight and blood glucose levels were monitored. Intraperitoneal glucose tolerance tests (IPGTTs) were performed. Immunofluorescence was carried out to monitor transduction utilising marker genes Venus and mCherry. RT-PCR was used to identify expression of pancreatic genes. Diabetic mice that received intraperitoneal (IP) injections of AAV8-INSFUR-mCherry (2.3x 1010-4.5x1010vg) became hypoglycaemic with abnormal responses to IPGTTs. No \u03b2-cell TF could be detected in the livers. Reversal of diabetes could not be achieved in the mice (n=8) that received combinations of AAV8-INSFUR-venus (5x1010 or 7.5x1010vg) and AAV8-Pdx1-mCherry (7.5x1010 vg). Both INSFUR and Pdx1 were detected using RT-PCR and immunofluorescence showed the expression of both marker genes. IPGTTs were abnormal; however, the \u03b2-cell TF MafA was detected by RT-PCR. Euglycaemia and normal IPGTTs were achieved in mice (n=4) that received AAV8\/piggyBac-INSFUR-mCherry (transposase 4x1010 vg and transposon 3.5x1010 vg). The INSFUR gene and the \u03b2-cell TFs NKx6.1 and MafA were detected in the livers, however wider evidence of pancreatic transdifferentiation was not seen. This is the first in vivo study using the hybrid AAV8\/piggyBac system to treat type 1 diabetes (T1D). The AAV system, with further development, may hold promise for gene therapy of T1D.<\/jats:p>\n \n Disclosure<\/jats:title>\n Q.T. La: None. B. Ren: None. G.J. Logan: None. S.C. Cunningham: None. N. Khandekar: None. N.T. Nassif: None. B.A. O'Brien: None. I.E. Alexander: Other Relationship; Self; LogicBio. A.M. Simpson: Consultant; Self; Pharmacyte Biotech.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-1778-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T01:38:56Z","timestamp":1559698736000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":3,"title":["1778-P: Delivery of the Insulin Gene Using an Integrating Adeno-Associated Viral Vector (AAV) to Diabetic NOD Mice"],"prefix":"10.2337","volume":"68","author":[{"given":"QUE T.","family":"LA","sequence":"first","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BINHAI","family":"REN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GRANT J.","family":"LOGAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHARON C.","family":"CUNNINGHAM","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NEETA","family":"KHANDEKAR","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NAJAH T.","family":"NASSIF","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRONWYN A.","family":"O'BRIEN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IAN E.","family":"ALEXANDER","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANN M.","family":"SIMPSON","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1778-P\/59185\/1778-P-Delivery-of-the-Insulin-Gene-Using-an","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1778-P\/59185\/1778-P-Delivery-of-the-Insulin-Gene-Using-an","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:06:37Z","timestamp":1647165997000},"score":7.8031473,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1778-P\/59185\/1778-P-Delivery-of-the-Insulin-Gene-Using-an"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-1778-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"1778-P"},{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:43:13Z","timestamp":1784205793549,"version":"3.55.0"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Gestational diabetes (GDM) is increasingly common and the burden to healthcare services is well recognized. Less understood is the emotional burden associated with a diagnosis of GDM, from the women\u2019s perspective. A qualitative study of women attending the Royal Prince Alfred Hospital, Sydney Antenatal Diabetes Service was undertaken during a 14-week period in 2018. Women were invited to complete an anonymous questionnaire which asked, \u201cHow do you feel about the diagnosis of Gestational Diabetes?\u201d Women were included in the study at three time points, i) newly diagnosed with GDM ii) at 36 weeks gestation and iii) at 3-month follow-up post-delivery. Responses were received from 189 women; 121, 32 and 36 at diagnosis, 36 weeks and post-delivery time points respectively. Their free text responses were transcribed and a thematic analysis of content was undertaken. Results were visualized using a word cloud and tag cloud generator (www.wordclouds.com) with font size representing the prominence or frequency of words expressed. As demonstrated by the images generated, the predominant feelings expressed at diagnosis were \u2018worried,\u2019 \u2018disappointed,\u2019 \u2018upset,\u2019 \u2018sad\u2019 and \u2018anxious.\u2019 These negative emotions prevailed irrespective of previous GDM experience and maternal age. At 36 weeks the predominant feelings expressed were \u2018frustrated,\u2019 \u2018disappointed,\u2019 \u2018worried,\u2019 \u2018upset\u2019 and \u2018anxious.\u2019 The primary emotion expressed in diet treated women was \u2018anxious\u2019 and in insulin treated women \u2018worried.\u2019 Post-delivery, the predominant words were \u2018relieved,\u2019 \u2018supported\u2019 and \u2018anxious.\u2019<\/jats:p>\n In conclusion, there was a high prevalence of negative emotion expressed by women with GDM at diagnosis which persisted throughout pregnancy and, for many, into the postnatal period. Clinicians need to be mindful of this high emotional burden with the aim to better support women with GDM and reduce associated distress.<\/jats:p>\n \n Disclosure<\/jats:title>\n A. Harding: None. M. McGill: None. A. Gauld: None. C.M. Pech: None. D. O'Connor: None. M.I. Constantino: None. G.P. Ross: Other Relationship; Self; Roche Diabetes Care Australia. T. Wu: Advisory Panel; Self; Boehringer Ingelheim International GmbH, Eli Lilly and Company, Novo Nordisk A\/S, Sanofi. Speaker's Bureau; Self; AstraZeneca, Boehringer Ingelheim International GmbH, Eli Lilly and Company, Merck Sharp & Dohme Corp., Novo Nordisk A\/S, Sanofi. J. Wong: Advisory Panel; Self; Sanofi. Speaker's Bureau; Self; AstraZeneca, Lilly Diabetes.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-2288-pub","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T02:20:32Z","timestamp":1559701232000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":3,"title":["2288-PUB: Capturing the Emotional Burden of Gestational Diabetes"],"prefix":"10.2337","volume":"68","author":[{"given":"ANNA-JANE","family":"HARDING","sequence":"first","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARGARET","family":"MCGILL","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AMANDA","family":"GAULD","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTINE M.","family":"PECH","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DANIEL","family":"O'CONNOR","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIA I.","family":"CONSTANTINO","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GLYNIS P.","family":"ROSS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TED","family":"WU","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JENCIA","family":"WONG","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/2288-PUB\/60154\/2288-PUB-Capturing-the-Emotional-Burden-of","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/2288-PUB\/60154\/2288-PUB-Capturing-the-Emotional-Burden-of","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:24:13Z","timestamp":1647167053000},"score":7.8031473,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/2288-PUB\/60154\/2288-PUB-Capturing-the-Emotional-Burden-of"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-2288-pub","ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"2288-PUB"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:35Z","timestamp":1753890035720,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Aim: Current guidelines recommend screening for retinopathy from 11 years in youth with type 1 diabetes (T1D) and 2-5 years T1D duration. We examined the longitudinal progression and regression of retinopathy in adolescents seen at our Diabetes Complications assessment service (DCAS) clinic.<\/jats:p>\n Methods: We analyzed digitized retinal photographs taken from 2000-2018 (n=814) in youth with &gt;3 assessments. Retinopathy was graded using the modified Airlie house classification. Generalized estimating equations were used to explore the association between progression\/regression and covariates (HbA1c, gender, and diabetes duration).<\/jats:p>\n Results: Mean age at baseline was 13.3+2.6 years, mean T1D duration 6.1+&gt;3.4 years and mean follow- up 7.4 years. Retinopathy was present in 18.7% (n=152) at baseline assessment; with progression in 32.6% (n=266), regression in 7% (n=57) and persistence in 60.3% (n=491). Of those with progression, 185\/266 (22.7%) had one step and 81 (9.9%) had &gt; 2 step progression. Factors associated with retinopathy progression were HbA1c and T1D duration and for regression T1D duration (Table 1). Neither height nor SBP was significant for other outcomes.<\/jats:p>\n Conclusion: In adolescents with T1D, retinopathy persistence or progression was greater than of regression. Follow-up of into adulthood will inform the development of appropriate retinopathy screening schedules.<\/jats:p>\n \n Disclosure<\/jats:title>\n V. Velayutham: None. G. Liew: None. A.S. Januszewski: None. Y. Cho: None. P.Z. Benitez-Aguirre: None. M.E. Craig: None. A. Jenkins: Advisory Panel; Self; Abbott, Australian Diabetes Society, Medtronic. Research Support; Self; Abbott, GlySens Incorporated, Medtronic, Mylan. Speaker's Bureau; Self; Eli Lilly and Company, Novo Nordisk Inc. K.C. Donaghue: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-595-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T03:12:24Z","timestamp":1559704344000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["595-P: Progression of Retinopathy in Adolescents with Type 1 Diabetes"],"prefix":"10.2337","volume":"68","author":[{"given":"VALLIMAYIL","family":"VELAYUTHAM","sequence":"first","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GERALD","family":"LIEW","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOON HI","family":"CHO","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL Z.","family":"BENITEZ-AGUIRRE","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA E.","family":"CRAIG","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KIM C.","family":"DONAGHUE","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/595-P\/58498\/595-P-Progression-of-Retinopathy-in-Adolescents","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/595-P\/58498\/595-P-Progression-of-Retinopathy-in-Adolescents","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:58:00Z","timestamp":1647165480000},"score":7.800061,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/595-P\/58498\/595-P-Progression-of-Retinopathy-in-Adolescents"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-595-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"595-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:52Z","timestamp":1753889872413,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: The 2025 ADA standards recognize early pregnancy dysglycemia is associated with worse outcomes, and recommend detection with either fasting glucose (FG) or A1C. This study compared different early glycemic screening strategies for overt diabetes (ODIP) and GDM prediction.<\/jats:p>\n Methods: Pregnant women with GDM risk factors enrolled in a multicenter early GDM RCT had a 75g OGTT and A1C &lt;20 wks using ADA ODIP and GDM criteria. Repeat OGTT occurred at 24-28 wks if untreated (normal OGTT and randomized 50% early GDM). Area under the receiver operator curve (AUROC) with 95%CI was used for ODIP and late GDM prediction. The proportion of late OGTTs avoided included those with an A1C or FG &lt;90% sensitivity thresholds or reaching the ADA early screening thresholds (A1C\u22655.9%; FG\u2265110 mg\/dL).<\/jats:p>\n Results: Among 3515 women, mean age was 31\u00b15 yrs, BMI 29.9\u00b17.4 kg\/m2, OGTT gestation 16\u00b13 wks, 40.6% were European. A1C and FG had similar AUROCs for ODIP and similar, but lower, AUROCs for GDM. The ADA-recommended A1C and FG thresholds were&lt;50% sensitive for ODIP and &lt;5% sensitive for GDM. An early FG threshold of 92 mg\/dL was &lt;70% sensitive for ODIP and persistent GDM. An early A1C threshold of 4.8% or FG of 76 mg\/dL (@90% sensitivity for GDM) could avoid 22.7% of 24-28 week OGTTs (Table 1).<\/jats:p>\n Conclusion: The 2025 ADA recommended early pregnancy A1C and FG thresholds are insensitive tests for detecting women with ODIP and later pregnancy GDM.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n D. Simmons: Research Support; Novo Nordisk, AMSL. Other Relationship; Abbott, Abbott, Boehringer-Ingelheim. Speaker's Bureau; Ascensia Diabetes Care. C.J. Nolan: None. J. Immanuel: None. H. Teede: None. J.R. Flack: None. V.W.M. Wong: None. E. Hibbert: None. M. McLean: Advisory Panel; Recordati Rare Diseases. A. Kautzky-Willer: None. J. Harreiter: None. H.E. Backman: None. E.J. Gianatti: None. A. Sweeting: None. V. Mohan: Speaker's Bureau; Novo Nordisk. Advisory Panel; Abbott. Research Support; Servier Laboratories. Speaker's Bureau; USV Private Limited, Sanofi, Medtronic, Eli Lilly and Company. W. Hague: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n NHMRC (grants 1104231 and 2009326); Region ?rebro Research Committee Dnr OLL-970566, OLL-942177; Medical Scientific Fund of the Mayor of Vienna, project 15205; South Western Sydney Local Health District Academic Unit grant 2016; Western Sydney University Ainsworth Trust grant 2019<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-178-or","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:18:53Z","timestamp":1749791933000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["178-OR: Sensitivity of Different Screening Approaches for Early Hyperglycemia in Pregnancy"],"prefix":"10.2337","volume":"74","author":[{"given":"DAVID","family":"SIMMONS","sequence":"first","affiliation":[{"name":"Campbelltown NSW, Australia, Woden, Australia, Campbelltowm, Australia, Melbourne, Australia, Bankstown, Australia, Liverpool, Australia, Kingswood, Australia, Sydney, Australia, Vienna, Austria, \u00d6rebro, Sweden, Palmyra DC, Australia, Chennai, India, North Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTOPHER J.","family":"NOLAN","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, Woden, Australia, Campbelltowm, Australia, Melbourne, Australia, Bankstown, Australia, Liverpool, Australia, Kingswood, Australia, Sydney, Australia, Vienna, Austria, \u00d6rebro, Sweden, Palmyra DC, Australia, Chennai, India, North Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JINCY","family":"IMMANUEL","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, Woden, Australia, Campbelltowm, Australia, Melbourne, Australia, Bankstown, Australia, Liverpool, Australia, Kingswood, Australia, Sydney, Australia, Vienna, Austria, \u00d6rebro, Sweden, Palmyra DC, Australia, Chennai, India, North Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HELENA","family":"TEEDE","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, Woden, Australia, Campbelltowm, Australia, Melbourne, Australia, Bankstown, Australia, Liverpool, Australia, Kingswood, Australia, Sydney, Australia, Vienna, Austria, \u00d6rebro, Sweden, Palmyra DC, Australia, Chennai, India, North Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEFF R.","family":"FLACK","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, Woden, Australia, Campbelltowm, Australia, Melbourne, Australia, Bankstown, Australia, Liverpool, Australia, Kingswood, Australia, Sydney, Australia, Vienna, Austria, \u00d6rebro, Sweden, Palmyra DC, Australia, Chennai, India, North Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VINCENT W.M.","family":"WONG","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, Woden, Australia, Campbelltowm, Australia, Melbourne, Australia, Bankstown, Australia, Liverpool, Australia, Kingswood, Australia, Sydney, Australia, Vienna, Austria, \u00d6rebro, Sweden, Palmyra DC, Australia, Chennai, India, North Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EMILY","family":"HIBBERT","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, Woden, Australia, Campbelltowm, Australia, Melbourne, Australia, Bankstown, Australia, Liverpool, Australia, Kingswood, Australia, Sydney, Australia, Vienna, Austria, \u00d6rebro, Sweden, Palmyra DC, Australia, Chennai, India, North Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK","family":"MCLEAN","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, Woden, Australia, Campbelltowm, Australia, Melbourne, Australia, Bankstown, Australia, Liverpool, Australia, Kingswood, Australia, Sydney, Australia, Vienna, Austria, \u00d6rebro, Sweden, Palmyra DC, Australia, Chennai, India, North Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALEXANDRA","family":"KAUTZKY-WILLER","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, Woden, Australia, Campbelltowm, Australia, Melbourne, Australia, Bankstown, Australia, Liverpool, Australia, Kingswood, Australia, Sydney, Australia, Vienna, Austria, \u00d6rebro, Sweden, Palmyra DC, Australia, Chennai, India, North Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00dcRGEN","family":"HARREITER","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, Woden, Australia, Campbelltowm, Australia, Melbourne, Australia, Bankstown, Australia, Liverpool, Australia, Kingswood, Australia, Sydney, Australia, Vienna, Austria, \u00d6rebro, Sweden, Palmyra DC, Australia, Chennai, India, North Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HELENA E.","family":"BACKMAN","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, Woden, Australia, Campbelltowm, Australia, Melbourne, Australia, Bankstown, Australia, Liverpool, Australia, Kingswood, Australia, Sydney, Australia, Vienna, Austria, \u00d6rebro, Sweden, Palmyra DC, Australia, Chennai, India, North Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EMILY J.","family":"GIANATTI","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, Woden, Australia, Campbelltowm, Australia, Melbourne, Australia, Bankstown, Australia, Liverpool, Australia, Kingswood, Australia, Sydney, Australia, Vienna, Austria, \u00d6rebro, Sweden, Palmyra DC, Australia, Chennai, India, North Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ARIANNE","family":"SWEETING","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, Woden, Australia, Campbelltowm, Australia, Melbourne, Australia, Bankstown, Australia, Liverpool, Australia, Kingswood, Australia, Sydney, Australia, Vienna, Austria, \u00d6rebro, Sweden, Palmyra DC, Australia, Chennai, India, North Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VISWANATHAN","family":"MOHAN","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, Woden, Australia, Campbelltowm, Australia, Melbourne, Australia, Bankstown, Australia, Liverpool, Australia, Kingswood, Australia, Sydney, Australia, Vienna, Austria, \u00d6rebro, Sweden, Palmyra DC, Australia, Chennai, India, North Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WILLIAM","family":"HAGUE","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, Woden, Australia, Campbelltowm, Australia, Melbourne, Australia, Bankstown, Australia, Liverpool, Australia, Kingswood, Australia, Sydney, Australia, Vienna, Austria, \u00d6rebro, Sweden, Palmyra DC, Australia, Chennai, India, North Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"TOBOGM RESEARCH GROUP","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/178-OR\/158662\/178-OR-Sensitivity-of-Different-Screening","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/178-OR\/158662\/178-OR-Sensitivity-of-Different-Screening","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T15:47:36Z","timestamp":1750434456000},"score":7.799748,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/178-OR\/158662\/178-OR-Sensitivity-of-Different-Screening"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-178-or","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"178-OR"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:39:19Z","timestamp":1753889959539,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Objective: Despite therapeutic advances, type 1 diabetes (T1D) is associated with a risk of development of micro- and macrovascular complications. Early treatment of complications is associated with a more favorable prognosis, hence biomarkers to enable early detection and to monitor treatments may be useful.<\/jats:p>\n Methods: Plasma (EDTA) samples were obtained from 30 adult (M\/F = 20\/10) individuals with T1D, age 42\u00b116 years, T1D duration 24\u00b111 years, HbA1c 7.5\u00b11.2% and BMI 26.5\u00b14.0 kg\/m2 (15 with microvascular complications (retinopathy or nephropathy) - CX+, and 15 without complications - CX-) and compared with 15 nondiabetic controls (CON, matched age, gender, smoking and BMI). T1D CX+ and CX- individuals were matched for age, gender, diabetes duration, smoking, BMI, HbA1c and insulin therapy modality (CSII\/MDI). In these discovery cohort samples, profiling of 754 miRs was done using a high throughput probe based quantitative PCR on nanofluidics Open Array platform . Results were analyzed using independent T test, Mann-Whitney test and classification trees. Statistical analysis was undertaken using R (ver. 3.5.1) and XLStat (ver. 2018.6).<\/jats:p>\n Results: Of 754 available miRs on the array, 186 miRs were detectable in plasma. Using an unbiased approach expression of 32 miRs differed significantly in CON vs. T1D and 16 miRs were differentially expressed between CX+ and CX- T1D subjects. Using a Random Forest wrapper algorithm 5 miRs were identified with importance for segregating CX+ vs. CX- status: miR-483-5p, miR-328, miR-1274B, miR-7 and miR-30a-5p. In logistic regression those 5 miRs provided a ROC curve with AUC=0.90 for the CX+ vs. CX- discrimination.<\/jats:p>\n Conclusion: In a discovery analysis of well- matched CX+ and CX- selected miRs provided good discrimination between T1D CX status. Validation studies in a larger cohort of cross-sectional and longitudinal samples are in progress.<\/jats:p>\n \n Disclosure<\/jats:title>\n A.S. Januszewski: None. E.S. Scott: None. M. Joglekar: None. L. Carroll: None. R. Farr: None. W. Wong: None. D.N. O\u2019Neal: None. C. Karschimkus: None. G. Fulcher: Advisory Panel; Self; Boehringer Ingelheim Pharmaceuticals, Inc., Janssen Research & Development, Merck Sharp & Dohme Corp., Novo Nordisk Inc. Consultant; Self; Boehringer Ingelheim Pharmaceuticals, Inc., Janssen Research & Development, Merck Sharp & Dohme Corp., Novo Nordisk Inc. Research Support; Self; Novo Nordisk Inc. A. Hardikar: None. A.J. Jenkins: Advisory Panel; Self; Abbott, Australian Diabetes Society, Medtronic. Research Support; Self; Abbott, GlySens Incorporated, Medtronic, Mylan. Speaker\u2019s Bureau; Self; Eli Lilly and Company, Novo Nordisk Inc.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Sydney Medical School Foundation; National Health and Medical Research Council of Australia<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-38-lb","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T02:55:06Z","timestamp":1559703306000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["38-LB: Discovery Analysis of MicroRNAs (miRs) Associated with Microvascular Complications in Adults with Type 1 Diabetes"],"prefix":"10.2337","volume":"68","author":[{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"first","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Fitzroy, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EMMA S.","family":"SCOTT","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Fitzroy, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MUGDHA","family":"JOGLEKAR","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Fitzroy, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUKE","family":"CARROLL","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Fitzroy, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RYAN","family":"FARR","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Fitzroy, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WILSON","family":"WONG","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Fitzroy, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O\u2019NEAL","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Fitzroy, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CONNIE","family":"KARSCHIMKUS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Fitzroy, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GREG","family":"FULCHER","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Fitzroy, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANAND","family":"HARDIKAR","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Fitzroy, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA J.","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Fitzroy, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/38-LB\/55210\/38-LB-Discovery-Analysis-of-MicroRNAs-miRs","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/38-LB\/55210\/38-LB-Discovery-Analysis-of-MicroRNAs-miRs","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:18:51Z","timestamp":1647163131000},"score":7.7991314,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/38-LB\/55210\/38-LB-Discovery-Analysis-of-MicroRNAs-miRs"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-38-lb","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"38-LB"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:31Z","timestamp":1753890031008,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Introduction: The prevalence of early-onset type 2 diabetes (EOT2D; diagnosed with T2DM before 40 years old), has increased sharply in recent years. Peripheral neuropathy (DPN) is a common and debilitating complication associated with T2DM, and it is also common in EOT2D, even among adolescents. Nerve excitability studies (NES) examine nerve axonal ion channel function; and may allow early detection of axonal dysfunction. The aim of this study was to explore the differences in NES outcomes between a cohort with EOT2D and matched healthy controls.<\/jats:p>\n Method: Thirteen participants with EOT2D with no clinical evidence of DPN and 14 matched healthy control participants (HC) were included in the study. Nerve conduction studies (NCS) were used to assess amplitude, latency, and conduction velocity in sural (sensory) and peroneal (motor) nerves. Motor and sensory NES were conducted on the median nerve. NES parameters assessed included strength-duration time constant, threshold electrotonus (TE), current-threshold relationship and recovery cycle. HbA1c was measured. Independent sample t-tests were used to compare the group means \u00b1 standard deviations.<\/jats:p>\n Results: Participants with EOT2D (F:M 5:8, age 34.1\u00b16.7yr, BMI 31.7\u00b15.4kg\u2219m-2) differed from matched HC (F:M 6:8, age 32.5\u00b15.1yr, BMI 29.6\u00b14.4kg\u2219m-2) for HbA1c (EOT2D=6.8\u00b11.0%, HC=5.2\u00b10.3%, p&lt;0.0001). There were no significant between-group differences in any NCS parameters, confirming the absence of clinical neuropathy. Minor changes in sensory axon NES were found in TE, which measures internodal conductances. Sensory depolarizing TE (TEd) at 10-20ms was decreased significantly in the EOT2D group (TEd 10-20ms: EOT2D = 60.1\u00b12.9ms, HC = 62.9\u00b13.0ms, p = 0.02). There were no significant changes in motor NES.<\/jats:p>\n Conclusion: Participants with EOT2D and no clinical evidence of DPN may demonstrate minor changes in sensory axonal function. Prospective studies are required to determine the clinical significance and progression of these changes.<\/jats:p>\n \n Disclosure<\/jats:title>\n Y. Gu: None. A.R. Harmer: None. S.M. Dennis: None. T. Li: None. H.C. Timmins: None. P. Loh: None. N. Garg: None. T. Dharmadasa: None. J. Wong: Advisory Panel; Self; Sanofi. Speaker\u2019s Bureau; Self; AstraZeneca, Merck & Co., Inc. A. Gauld: None. P.A. Munoz: None. S.B. Park: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Diabetes Australia; Sydney Local Health District<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-559-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:52Z","timestamp":1592238592000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["559-P: Signs of Early Change in Peripheral Axons in People with Early-Onset Type 2 Diabetes Mellitus"],"prefix":"10.2337","volume":"69","author":[{"given":"YU","family":"GU","sequence":"first","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALISON R.","family":"HARMER","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SARAH M.","family":"DENNIS","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIFFANY","family":"LI","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HANNAH C.","family":"TIMMINS","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PATRICIA CHIN","family":"TIEN LOH","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NIDHI","family":"GARG","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"THANUJA","family":"DHARMADASA","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENCIA","family":"WONG","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AMANDA","family":"GAULD","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PHILLIP A.","family":"MUNOZ","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUSANNA B.","family":"PARK","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/559-P\/58003\/559-P-Signs-of-Early-Change-in-Peripheral-Axons-in","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/559-P\/58003\/559-P-Signs-of-Early-Change-in-Peripheral-Axons-in","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:47:41Z","timestamp":1647164861000},"score":7.7985125,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/559-P\/58003\/559-P-Signs-of-Early-Change-in-Peripheral-Axons-in"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-559-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"559-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:03Z","timestamp":1753889823387,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Background: Hybrid closed loop (HCL) insulin delivery with the Medtronic MiniMed 670G system is safe and effective in improving glycemia for people with type 1 diabetes (T1D).<\/jats:p>\n Aims: To compare glucose control, CL exits and alarm frequency with standard HCL vs. enhanced HCL (eHCL) systems.<\/jats:p>\n Methods: Pump experienced adults with T1D (n=11; 9 women; mean[SD] age: 51[15]Y; HbA1c 7.5[1.0]%) were assigned in random order HCL and eHCL for 1 week each in a supervised live-in setting. eHCL incorporated enhanced bolus reminders and iterative changes broadening glucose and insulin delivery parameters permitting persistence in CL. For both HCL and eHCL insulin delivery was by a Medtronic pump with identical interventions (missed bolus, exercise, high GI and high fat meals), insulin action times and insulin-carbohydrate ratios implemented. The primary outcome was CGM time in target range.<\/jats:p>\n Results: eHCL resulted in fewer CL alerts and exits. Time in target and mean glucose favored eHCL but did not reach significance (Table). No episodes of severe hypoglycemia or ketoacidosis occurred.<\/jats:p>\n Conclusions: Iterative changes to the Medtronic HCL system resulted in trends towards improved glycemia, fewer CL exits and alerts without compromising safety, despite multiple food and exercise challenges during the study periods. Longer term studies at home are required to confirm these findings.<\/jats:p>\n Table: All results are Mean (SD); *NS= Not Significant.HCL (n=11)eHCL (n=11)pInsulin DeliveryTotal daily insulin (units\/day)44 (18)47 (24)NS*Daily basal (%)55 (8)55 (7)NS*Daily bolus (%)45 (8)45 (7)NS*Daily insulin to carbohydrate ratio9.6 (3.1)9.6 (3.1)NS*Insulin action time (hrs)3.7 (0.6)3.7 (0.6)NS*Glucose Metrics% time in 70-180mg\/dL69 (11)74 (10)0.16Mean sensor glucose (mg\/dL)160 (13)151 (11)0.091Time &lt;70mg\/dL (%)1.9 (2.4)1.2 (1.2)0.42Time &lt;50mg\/dL (%)0.4 (0.5)0.2 (0.3)0.21Time&gt;180mg\/dL (%)29 (11)24 (9)0.37Time &gt;250mg\/dL (%)7.3 (5.6)6.1 (4.7)0.48Algorithm related Alerts and Dropout Alerts (n\/week)8.6 (5.8)3.9 (2.8)0.01CL exits (n\/week)3.5 (3.1)0 (0)0.004<\/jats:p>\n \n Disclosure<\/jats:title>\n B. Paldus: None. M.H. Lee: None. H. Jones: None. S.A. McAuley: Research Support; Self; JDRF. Speaker's Bureau; Self; Novo Nordisk Inc., Australian Diabetes Society. J.C. Horsburgh: None. K.L. Roem: None. G. Ward: None. R. MacIsaac: None. N. Cohen: None. P.G. Colman: None. A. Jenkins: Research Support; Self; Medtronic, Mylan, Sanofi-Aventis. D.N. O'Neal: Research Support; Self; Medtronic MiniMed, Inc.. Advisory Panel; Self; Medtronic MiniMed, Inc.. Speaker's Bureau; Self; Medtronic MiniMed, Inc.. Advisory Panel; Self; Abbott. Speaker's Bureau; Self; Novo Nordisk Inc.. Advisory Panel; Self; Novo Nordisk Inc.. Research Support; Self; Novo Nordisk Inc.. Advisory Panel; Self; Sanofi. Research Support; Self; Sanofi.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-986-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:35Z","timestamp":1529693855000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Glucose Control Using a Standard vs. an Enhanced Hybrid Closed-Loop System\u2014A Pilot Study"],"prefix":"10.2337","volume":"67","author":[{"given":"BARBORA","family":"PALDUS","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MELISSA H.","family":"LEE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HANNAH","family":"JONES","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SYBIL A.","family":"MCAULEY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JODIE C.","family":"HORSBURGH","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KERRYN L.","family":"ROEM","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GLENN","family":"WARD","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"MACISAAC","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NEALE","family":"COHEN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER G.","family":"COLMAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/986-P\/54852\/Glucose-Control-Using-a-Standard-vs-an-Enhanced","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/986-P\/54852\/Glucose-Control-Using-a-Standard-vs-an-Enhanced","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:15:39Z","timestamp":1647162939000},"score":7.7984724,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/986-P\/54852\/Glucose-Control-Using-a-Standard-vs-an-Enhanced"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-986-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"986-P"},{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:25:34Z","timestamp":1784546734924,"version":"3.55.0"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,6,14]]},"abstract":"Introduction: Robust predictive measures for Type 2 diabetes (T2D) vascular complications to facilitate early intervention strategies are needed.<\/jats:p>\n Methods: Fasting plasma from 363 Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial participants (mean\u00b1SD) age: 61.3\u00b16.4 yrs, 5.6\u00b15.4 yrs T2D, HbA1c: 6.7\u00b11.2% (49.7\u00b113.4 mmol\/mol), were collected at baseline and stored (-80\u00b0C) until quantitative proteomics analysis of tryptic peptides. Protein signatures associated with future micro- or macrovascular complications (100 and 54 subjects, respectively) were identified using a random forest approach, adjusted for treatment allocation. Exhaustive search using logistic regression was then carried out to optimise models. Pathway analysis was carried out using the NIH functional annotation tool, DAVID Bioinformatics. Resources.<\/jats:p>\n Results: Fifty targets were selected: 14 were associated with microvascular, 13 with macrovascular complications and 23 were common for both. Pathway analysis revealed six main pathways: cholesterol metabolism, platelet activation, complement and coagulation, focal cell adhesion, actin cytoskeleton and hypertrophic cardiomyopathy. In logistic regression, the optimal model for prediction of microvascular complications with overall p&lt;0.0001, AUC=0.74 contained Cadherin-5, Clusterin, Ceruloplasmin, Glutathione peroxidase 3 and Inter-alpha-trypsin inhibitor heavy chain H3. For macrovascular complications the model contained Zinc-alpha-2-glycoprotein and Coagulation factor V (p&lt;0.0001, AUC=0.72). For any micro- or macro-vascular complications, the model contained Cholinesterase, Ceruloplasmin, Mannose-binding protein C and Coagulation factor V (p&lt;0.0001, AUC=0.70).<\/jats:p>\n Conclusion: Proteomic signatures represent a promising first step towards identifying protein signatures associated with T2D complications. Future research will aim at finding therapeutic targets in the metabolic pathways identified by those proteins.<\/jats:p>\n \n Disclosure<\/jats:title>\n H. Francis: None. A.S. Januszewski: None. A.A. Hardikar: None. M.V. Joglekar: None. D. Sullivan: None. A. Jenkins: Research Support; Abbott, Viatris Inc. Advisory Panel; Abbott. Research Support; Medtronic. Board Member; Insulin for Life. Research Support; Leona M. and Harry B. Helmsley Charitable Trust, Juvenile Diabetes Research Foundation (JDRF), Jaeb Center for Health Research, National Institutes of Health, National Health and Medical Research Council Australia. M.P. Molloy: None. A.C. Keech: Research Support; Abbott, Amgen Inc., Bayer Inc., Kowa Company, Ltd., Mylan. Speaker's Bureau; Novartis Pharmaceuticals Corporation. Research Support; Novartis Pharmaceuticals Corporation, Sanofi, Viatris Inc.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Health and Medical Research Council (GNT1147897)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db24-1799-lb","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T06:36:21Z","timestamp":1718346981000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["1799-LB: Identification of Proteomics Signature for Vascular Complications in Type 2 Diabetes"],"prefix":"10.2337","volume":"73","author":[{"given":"HABIB","family":"FRANCIS","sequence":"first","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Campbelltown, Australia, Camperdown, Australia, St. Leonards, Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Campbelltown, Australia, Camperdown, Australia, St. Leonards, Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MATTHEW","family":"O'ROURKE","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Campbelltown, Australia, Camperdown, Australia, St. Leonards, Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHAEL L.","family":"HUANG","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Campbelltown, Australia, Camperdown, Australia, St. Leonards, Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANANDWARDHAN A.","family":"HARDIKAR","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Campbelltown, Australia, Camperdown, Australia, St. Leonards, Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MUGDHA V.","family":"JOGLEKAR","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Campbelltown, Australia, Camperdown, Australia, St. Leonards, Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVID","family":"SULLIVAN","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Campbelltown, Australia, Camperdown, Australia, St. Leonards, Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Campbelltown, Australia, Camperdown, Australia, St. Leonards, Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARK P.","family":"MOLLOY","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Campbelltown, Australia, Camperdown, Australia, St. Leonards, Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANTHONY C.","family":"KEECH","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Campbelltown, Australia, Camperdown, Australia, St. Leonards, Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ON","family":"BEHALF OF THE FIELD STUDY INVESTIGATORS","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Campbelltown, Australia, Camperdown, Australia, St. Leonards, Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/1799-LB\/156059\/1799-LB-Identification-of-Proteomics-Signature-for","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/1799-LB\/156059\/1799-LB-Identification-of-Proteomics-Signature-for","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T06:36:21Z","timestamp":1718346981000},"score":7.797764,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/1799-LB\/156059\/1799-LB-Identification-of-Proteomics-Signature-for"}},"issued":{"date-parts":[[2024,6,14]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2024,6,14]]}},"URL":"https:\/\/doi.org\/10.2337\/db24-1799-lb","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2024,6,14]]},"article-number":"1799-LB"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:24Z","timestamp":1753889844972,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: We have previously identified 50 proteins associated with T2D vascular complications (CX). We now measured their mRNA expression in T2D patients with and without CX.<\/jats:p>\n Methods: RNA was extracted from citrate plasma samples of 542 people with T2D from the Fenofibrate Intervention and Event Lowering in Diabetes trial (Age: 62\u00b17 yrs; T2D duration: 6\u00b16 yrs; HbA1c: 6.8\u00b11.3%). There were n=179 participants with CX at baseline, n=142 developing first CX during follow-up (FUP) and n=221 who had no CX. OpenArray was used to measure mRNA with normalisation using housekeeping gene (MT-ATP6). For differences between groups \u0394\u0394CT values were used.<\/jats:p>\n Results: Seven genes had circulating mRNA levels below the detection limit in all samples, 32 were detected in &lt; 20% of samples. The remaining 11 genes were detected in 23-90% of samples. Genes differentially expressed between T2D patients with and without CX were involved in vascular repair and extracellular matrix remodeling. E.g. FERMT3 mRNA was 1.8-fold higher in those developing macroCX during FUP vs. no CX group. Clusterin mRNA was 1.1-1.5-fold higher with CX during FUP and 1.3-1.7-fold higher with baseline CX vs. no CX. Comparisons of proteomic and mRNA levels across the study groups revealed that in 32% of cases differences in mRNA levels were paralleled in protein level differences. E.g. TLN1 exhibited reduced mRNA and protein expression in subjects who developed both micro- and\/or macroCX during FUP. In contrast, in 45% of instances, differences in mRNA were not paralleled by the same differences in protein expression, suggesting potential post-transcriptional regulation in those pathways.<\/jats:p>\n Conclusion: These findings underscore the importance of integrating transcriptomic and proteomic analyses to better understand the molecular mechanisms driving vascular complications in T2D and to identify potential therapeutic targets.<\/jats:p>\n \n Disclosure<\/jats:title>\n H. Francis: None. A.S. Januszewski: None. M. O'Rourke: None. M.L. Huang: None. F. Ema: None. A.A. Hardikar: None. M.V. Joglekar: None. D. Sullivan: Other Relationship; Amgen Inc. Research Support; Arrowhead Pharmaceuticals, Inc. Other Relationship; Novartis Pharmaceuticals Corporation, Merck Sharp & Dohme Corp. Research Support; Ionis Pharmaceuticals. R.S. Scott: None. A. Jenkins: Advisory Panel; Abbott. Speaker's Bureau; GlaxoSmithKline plc. Research Support; Abbott, Metronics, Ypsomed AG, Insulet Corporation, Jaeb Center for Health Research, Endogenex, Hemsley Charitable Trust. Speaker's Bureau; CSL Seqirus. Research Support; AbbVie Inc, National Institutes of Health, Juvenile Diabetes Research Foundation (JDRF). M.P. Molloy: None. A.C. Keech: Research Support; Abbott, Amgen Inc, ASPEN Australia, Mylan. Speaker's Bureau; Novartis AG, Pfizer Inc. Research Support; Kowa Company, Ltd. Speaker's Bureau; Sanofi. Research Support; AbbVie Inc, Viatris Inc.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Health and Medical Research Council of Australia (GNT1147879)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-444-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T06:46:46Z","timestamp":1749797206000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["444-P: Protein and mRNA Comparison in Complications of Type 2 Diabetes\u2014Integrating Proteomics with Transcriptomics"],"prefix":"10.2337","volume":"74","author":[{"given":"HABIB","family":"FRANCIS","sequence":"first","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Sydney, Australia, Campbelltown, Australia, Camperdown, Australia, Christchurch, New Zealand, St. Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Sydney, Australia, Campbelltown, Australia, Camperdown, Australia, Christchurch, New Zealand, St. Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MATTHEW","family":"O'ROURKE","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Sydney, Australia, Campbelltown, Australia, Camperdown, Australia, Christchurch, New Zealand, St. Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL L.","family":"HUANG","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Sydney, Australia, Campbelltown, Australia, Camperdown, Australia, Christchurch, New Zealand, St. Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FAHMIDA","family":"KHAN EMA","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Sydney, Australia, Campbelltown, Australia, Camperdown, Australia, Christchurch, New Zealand, St. Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANANDWARDHAN A.","family":"HARDIKAR","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Sydney, Australia, Campbelltown, Australia, Camperdown, Australia, Christchurch, New Zealand, St. Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MUGDHA V.","family":"JOGLEKAR","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Sydney, Australia, Campbelltown, Australia, Camperdown, Australia, Christchurch, New Zealand, St. Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"SULLIVAN","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Sydney, Australia, Campbelltown, Australia, Camperdown, Australia, Christchurch, New Zealand, St. Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RUSSELL S.","family":"SCOTT","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Sydney, Australia, Campbelltown, Australia, Camperdown, Australia, Christchurch, New Zealand, St. Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Sydney, Australia, Campbelltown, Australia, Camperdown, Australia, Christchurch, New Zealand, St. Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK P.","family":"MOLLOY","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Sydney, Australia, Campbelltown, Australia, Camperdown, Australia, Christchurch, New Zealand, St. Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTHONY C.","family":"KEECH","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Niagara Park, Australia, Melbourne, Australia, Sydney, Australia, Campbelltown, Australia, Camperdown, Australia, Christchurch, New Zealand, St. Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/444-P\/160062\/444-P-Protein-and-mRNA-Comparison-in-Complications","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/444-P\/160062\/444-P-Protein-and-mRNA-Comparison-in-Complications","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T16:56:05Z","timestamp":1750438565000},"score":7.7965913,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/444-P\/160062\/444-P-Protein-and-mRNA-Comparison-in-Complications"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-444-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"444-P"},{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:05:27Z","timestamp":1780704327151,"version":"3.54.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2026,6,5]]},"abstract":"Introduction and Objective: Mental health (MH) conditions are common among young people with diabetes, affecting self-management and increasing complications risk. The aim of this trial was to test the efficacy of an app to reduce distress among young adults with diabetes.<\/jats:p>\n Methods: This multicenter, open-label trial (ACTRN12623000734662) randomized young adults aged 16-30y with diabetes and a MH condition from 8 Australian hospitals to start a bespoke app providing both diabetes and MH self-management tools or continue with standard care. Presence of a MH condition was defined as any past history, the presence of a Kessler Psychological Distress Scale (K10) \u226540 and\/or a Problem Areas in Diabetes (PAID) scale \u2265 20. The primary outcome was change in K10, and secondary outcomes included change in PAID or HbA1c, assessed at baseline and 6 months. Analyses were performed by both intention to treat (ITT) and per-protocol (PP) by a blinded statistician.<\/jats:p>\n Results: Of the 142 participants (mean age 22\u00b14y), 50% female, 71.8% European, BMI 27.6\u00b16.3 kg\/m2, 95.1% Type 1 diabetes), 71 were randomised to the app, with 68% (48\/71) successfully onboarding. Engagement was high (6-7 sessions and 3 tasks\/day). The crude mean (SD) difference (Intervention vs control) in K10 was not significantly different by ITT: -4.74 (8.59) vs -3.48 (6.41), Treatment effect (95% CI) -1.23 (-4.25,1.8) or PP: -4.06 (9.06) vs -3.11 (5.96) respectively, Treatment effect-1.28 (-4.31,2.19). The crude mean (SD) difference in PAID was not significantly different in the ITT analysis -8.83 (16.99) vs -4.14 (16.57), Treatment effect -4.88 (-12.05,2.29) (ITT) but significantly lower in the PP analysis: -9.6 (16.65) vs -3.05 (16.62) respectively, Treatment effect: -7.67 (-15.05, -0.06, p=0.047). The HbA1c and weight differences trended downwards but were not significant.<\/jats:p>\n Conclusion: While only 2\/3 of young adults with diabetes with MH onboarded the app, those who did engaged well with a reduction in PAID score. Larger trials are needed to test whether apps can improve the MH of young adults with diabetes.<\/jats:p>\n \n Disclosure<\/jats:title>\n D. Simmons: Speaker's Bureau; Ended; Novo Nordisk. Other - Educational grant; Ended; Abbott Diabetes. Research Support; Current; Novo Nordisk. Consultant; Ended; Dexcom, Inc. S. Abdo: None. J. Greenfield: Research Support; Current; Novo Nordisk A\/S. M.E. Craig: None. M. Reyes: Speaker's Bureau; Current; Lilly. R. Hicks: None. W.K. Tannous: None. T. Wong: None. V.W. Wong: None. K.O. Mathews: None. M. Piya: Advisory Panel; Ended; Novo Nordisk. Speaker's Bureau; Current; Novo Nordisk. Advisory Panel; Ended; Eli Lilly and Company. Speaker's Bureau; Current; Eli Lilly and Company. Advisory Panel; Ended; Boehringer Ingelheim International GmbH. Speaker's Bureau; Ended; Johnson & Johnson. Research Support; Ended; Abbott Diabetes. P. Hay: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n MTPConnect (TTRA2004)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db26-1052-or","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:41:41Z","timestamp":1780702901000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1052-OR: A Multicenter Randomized Controlled Trial of an App to Reduce Distress among Young Adults with Diabetes"],"prefix":"10.2337","volume":"75","author":[{"given":"DAVID","family":"SIMMONS","sequence":"first","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Darlinghurst, Australia, Westmead, Australia, Kogarah, Australia, Parramatta, Australia, Bankstown, Australia, Liverpool, Australia, Campbelltown, NSW, Australia, Campbelltown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SARAH","family":"ABDO","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Darlinghurst, Australia, Westmead, Australia, Kogarah, Australia, Parramatta, Australia, Bankstown, Australia, Liverpool, Australia, Campbelltown, NSW, Australia, Campbelltown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JERRY","family":"GREENFIELD","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Darlinghurst, Australia, Westmead, Australia, Kogarah, Australia, Parramatta, Australia, Bankstown, Australia, Liverpool, Australia, Campbelltown, NSW, Australia, Campbelltown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIA E.","family":"CRAIG","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Darlinghurst, Australia, Westmead, Australia, Kogarah, Australia, Parramatta, Australia, Bankstown, Australia, Liverpool, Australia, Campbelltown, NSW, Australia, Campbelltown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHAEL","family":"REYES","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Darlinghurst, Australia, Westmead, Australia, Kogarah, Australia, Parramatta, Australia, Bankstown, Australia, Liverpool, Australia, Campbelltown, NSW, Australia, Campbelltown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RACHEL","family":"HICKS","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Darlinghurst, Australia, Westmead, Australia, Kogarah, Australia, Parramatta, Australia, Bankstown, Australia, Liverpool, Australia, Campbelltown, NSW, Australia, Campbelltown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WADAD K.","family":"TANNOUS","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Darlinghurst, Australia, Westmead, Australia, Kogarah, Australia, Parramatta, Australia, Bankstown, Australia, Liverpool, Australia, Campbelltown, NSW, Australia, Campbelltown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TANG","family":"WONG","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Darlinghurst, Australia, Westmead, Australia, Kogarah, Australia, Parramatta, Australia, Bankstown, Australia, Liverpool, Australia, Campbelltown, NSW, Australia, Campbelltown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VINCENT W.M.","family":"WONG","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Darlinghurst, Australia, Westmead, Australia, Kogarah, Australia, Parramatta, Australia, Bankstown, Australia, Liverpool, Australia, Campbelltown, NSW, Australia, Campbelltown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAREN O.","family":"MATHEWS","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Darlinghurst, Australia, Westmead, Australia, Kogarah, Australia, Parramatta, Australia, Bankstown, Australia, Liverpool, Australia, Campbelltown, NSW, Australia, Campbelltown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MILAN","family":"PIYA","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Darlinghurst, Australia, Westmead, Australia, Kogarah, Australia, Parramatta, Australia, Bankstown, Australia, Liverpool, Australia, Campbelltown, NSW, Australia, Campbelltown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PHILLIPA","family":"HAY","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Darlinghurst, Australia, Westmead, Australia, Kogarah, Australia, Parramatta, Australia, Bankstown, Australia, Liverpool, Australia, Campbelltown, NSW, Australia, Campbelltown, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/1052-OR\/168599\/1052-OR-A-Multicenter-Randomized-Controlled-Trial","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/1052-OR\/168599\/1052-OR-A-Multicenter-Randomized-Controlled-Trial","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:41:41Z","timestamp":1780702901000},"score":7.7940435,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/1052-OR\/168599\/1052-OR-A-Multicenter-Randomized-Controlled-Trial"}},"issued":{"date-parts":[[2026,6,5]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2026,6,5]]}},"URL":"https:\/\/doi.org\/10.2337\/db26-1052-or","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2026,6,5]]},"article-number":"1052-OR"},{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:52:04Z","timestamp":1759179124489,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"Aims: To assess the effect of early intervention with electronic-based proactive specialist diabetes care in surgical inpatients on glycaemia and clinical outcomes.<\/jats:p>\n Methods: The Specialist Treatment of Inpatients: Caring for Diabetes (STOIC-D) Surgery randomised controlled trial (RCT) recruited consecutive adults admitted to surgical units of the Royal Melbourne Hospital (Australia) in 2021 with diabetes or blood glucose \u2265200 mg\/dL and length of stay (LOS) \u226524 hours. Intervention arm patients received remote proactive consultation by the inpatient diabetes service (IDS) in the electronic medical record (Epic\u00ae) within 24 hours of admission and, if escalation criteria were met, received a bedside consultation. Patients receiving standard care were reviewed by the IDS at the bedside only following referral. Insulin and non-insulin agents were used to target glucose 90-180 mg\/dL. Outcomes included glucometrics, healthcare-associated infection (HAI), and mortality. Registration: ACTRN12620001303932.<\/jats:p>\n Results: 1,383 admissions met inclusion criteria; 689 received the intervention. The primary outcome of mean patient-day mean glucose was lower in the active (158.4 mg\/dL, standard deviation [SD] 48.6) vs. control arm (162.0 mg\/dL, SD 46.8, p&lt;0.001). HAI (most commonly pneumonia) was lower in the active vs. control arm (11% vs. 16%, p=0.02). Mortality (2.4% vs. 4.2%, p=0.08) and LOS (10.7 vs. 10.0 days, p=0.26) were no different. The number needed to treat for HAI prevention was 22. Hypoglycaemia &lt;72 mg\/dL was not increased (1.0% active vs. 0.9% control, p=0.23). The IDS performed a bedside consultation in 333 (49%) of the active vs. 93 (14%) of the control arm.<\/jats:p>\n Conclusion: The STOIC-D Surgery trial is the largest RCT of a diabetes model-of-care intervention in non-critical care. Early, electronic-based specialist diabetes intervention significantly reduced patient-day mean glucose and HAIs in a surgical population.<\/jats:p>\n \n Disclosure<\/jats:title>\n R.Barmanray: None. L.J.Worth: None. S.Fourlanos: Advisory Panel; Viatris Inc., Pfizer Inc., Speaker's Bureau; Novo Nordisk, AstraZeneca, Boehringer Ingelheim and Eli Lilly Alliance. M.Kyi: None. P.G.Colman: None. L.M.Rowan: None. L.Collins: None. L.E.Donaldson: Stock\/Shareholder; Medtronic, Novo Nordisk. S.Montalto: None. E.Sun: None. M.V.H.Le: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-165-or","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:24:07Z","timestamp":1687242247000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["165-OR: Early Electronic Consultation Reduces Glucose and Health Care\u2013Associated Infection in Hospital\u2014The STOIC-D Surgery Randomised Controlled Trial"],"prefix":"10.2337","volume":"72","author":[{"given":"RAHUL","family":"BARMANRAY","sequence":"first","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MERVYN","family":"KYI","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER G.","family":"COLMAN","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LOIS M.","family":"ROWAN","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUCY","family":"COLLINS","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LAURA E.","family":"DONALDSON","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHANIE","family":"MONTALTO","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EMILY","family":"SUN","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MINH V.H.","family":"LE","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEON J.","family":"WORTH","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SPIROS","family":"FOURLANOS","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/165-OR\/150718\/165-OR-Early-Electronic-Consultation-Reduces","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/165-OR\/150718\/165-OR-Early-Electronic-Consultation-Reduces","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:24:08Z","timestamp":1687242248000},"score":7.7910748,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/165-OR\/150718\/165-OR-Early-Electronic-Consultation-Reduces"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-165-or","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"165-OR"},{"indexed":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T05:15:35Z","timestamp":1678511735765},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Supplement 4","content-domain":{"domain":["www.auajournals.org"],"crossmark-restriction":true},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1097\/01.ju.0000556027.16655.05","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T05:40:57Z","timestamp":1556084457000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["MP36-17\u2003DEFINING BIOCHEMICAL RECURRENCE IN PROSTATE CANCER WITH HYBRID PSMA PET MRI"],"prefix":"10.1097","volume":"201","author":[{"given":"Paria","family":"Saadat","sequence":"first","affiliation":[{"name":"South Brisbane, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Mehawed*","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Ong","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Joshi","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Roberts","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlon","family":"Perera","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handoo","family":"Rhee","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeates","family":"Alexander","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janelle","family":"Munns","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Malone","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Chung","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Heathcote","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Preston","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawson","family":"Malcolm","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Wood","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pryor","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"Lehman","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustafson","family":"Sonja","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Miles","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Ngai","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Vela","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"http:\/\/www.auajournals.org\/doi\/pdf\/10.1097\/01.JU.0000556027.16655.05","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T16:23:53Z","timestamp":1678465433000},"score":7.790024,"resource":{"primary":{"URL":"http:\/\/www.auajournals.org\/doi\/10.1097\/01.JU.0000556027.16655.05"}},"issued":{"date-parts":[[2019,4]]},"references-count":0,"journal-issue":{"issue":"Supplement 4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1097\/01.JU.0000556027.16655.05"],"URL":"https:\/\/doi.org\/10.1097\/01.ju.0000556027.16655.05","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"2019-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:10Z","timestamp":1753889830291,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Background: The prevalence of early-onset type 2 diabetes (EOT2D, diagnosed with T2DM under the age 40) is increasing. There is limited research on the perceptions and knowledge about diabetes and its management. The aim of the study was to explore the insights on diabetes and exercise among this cohort.<\/jats:p>\n Method: Twelve participants who underwent an 8-week, supervised, high-intensity intermittent training (HIIT) program were invited to participate in a semi-structured interview. The interview explored exercise history, perception of EOT2D, knowledge of EOT2D management and complications, feedback on HIIT, and barriers and facilitators to regular exercise. Inductive thematic analysis was used.<\/jats:p>\n Results: Eight males and four females aged between 20-44 years were interviewed. Four themes emerged from analysis: (i) The diagnosis of T2DM was often unexpected. Participants reported the sense of \u201closs control\u201d at diagnosis. This motivated people to exercise, but regular and structured exercise was rarely maintained: \u201cdidn\u2019t continue after a few months.\u201d (ii) Participants had varying levels of knowledge about diabetes, its management and complications: \u201c\u22efdidn\u2019t really understand how T2DM works and how exercise could affect it.\u201d Most participants did not monitor blood glucose levels regularly: \u201cmonitoring sugar regularly to me is obsessive behaviour.\u201d (iii) Financial and time commitments were the two most common barriers to exercise, especially for people with young children. (iv) HIIT was well-tolerated. Participants valued the individual supervision - \u201chaving the supervision gives you structure and a commitment.\u201d However, participants were unlikely to continue with the HIIT program independently or unsupervised.<\/jats:p>\n Clinical implication: Although diagnosis of EOT2D can be an impetus for behaviour change, diabetes management in this cohort was not prioritised over work and family commitments. Diabetes management and education in this young cohort needs to have tailored approaches.<\/jats:p>\n \n Disclosure<\/jats:title>\n Y. Gu: None. A. Harmer: None. J. Wong: Advisory Panel; Self; Sanofi. Speaker\u2019s Bureau; Self; AstraZeneca, Merck & Co., Inc. A. Gauld: None. M.I. Constantino: None. P.A. Munoz: None. S. Dennis: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Diabetes Australia; Sydney Local Health District<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-1236-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:46Z","timestamp":1592238586000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1236-P: Perceptions of People with Early-Onset Type 2 Diabetes Mellitus about Diabetes and Exercise"],"prefix":"10.2337","volume":"69","author":[{"given":"YU","family":"GU","sequence":"first","affiliation":[{"name":"Lidcombe, Australia, Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALISON","family":"HARMER","sequence":"additional","affiliation":[{"name":"Lidcombe, Australia, Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENCIA","family":"WONG","sequence":"additional","affiliation":[{"name":"Lidcombe, Australia, Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AMANDA","family":"GAULD","sequence":"additional","affiliation":[{"name":"Lidcombe, Australia, Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA I.","family":"CONSTANTINO","sequence":"additional","affiliation":[{"name":"Lidcombe, Australia, Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PHILLIP A.","family":"MUNOZ","sequence":"additional","affiliation":[{"name":"Lidcombe, Australia, Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SARAH","family":"DENNIS","sequence":"additional","affiliation":[{"name":"Lidcombe, Australia, Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1236-P\/61054\/1236-P-Perceptions-of-People-with-Early-Onset-Type","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1236-P\/61054\/1236-P-Perceptions-of-People-with-Early-Onset-Type","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:21:14Z","timestamp":1647166874000},"score":7.786231,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1236-P\/61054\/1236-P-Perceptions-of-People-with-Early-Onset-Type"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-1236-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"1236-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:13Z","timestamp":1753889833815,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2021,6,1]]},"abstract":"Background: In addition to the acute illness associated with DKA at diagnosis of T1D in children, there is some evidence of its association with poor long-term glycaemic outcomes, increasing risk of complications. With growing global interest in screening for pre-diabetes in children, long-term outcomes are an important consideration in terms of economic viability but there is limited high quality data. This population-based study helps to address this gap.<\/jats:p>\n Methods: All children &lt;16 years presenting to Perth Children\u2019s Hospital with new onset T1D 2000-2019 were included and followed up for \u2264 14 years. Moderate-severe DKA at diagnosis was defined as serum pH &lt;7.2 or bicarb &lt;15mmol\/l in the presence of hyperglycaemia and ketosis. HbA1c was recorded at each clinic visit, ~3 monthly from diagnosis. A linear mixed model, adjusted for sex, diagnosis age, socioeconomic status and metro\/regional area of residence, was used to examine long-term HbA1c associated with DKA at diagnosis at each year of duration.<\/jats:p>\n Results: The population-based cohort included 2063 patients and median [IQR] follow-up time was 5.4 [3.0-8.4] years. The incidence of DKA at diagnosis was 25%. Patients presenting with DKA had a higher mean HbA1c at diagnosis as expected but from 2 to 7 years post-diagnosis there was no difference between the two groups. Mean HbA1c of patients presenting with DKA increased relative to the remainder from 7 years. The only comparable study, conducted in Colorado in 2017, reported an immediate and sustained relationship between DKA severity at onset and HbA1c over 15 years.<\/jats:p>\n Conclusion: The difference in findings for similar cohorts in Australia and the US raises questions regarding the variables that influence long-term glycaemic outcomes in children diagnosed with T1D. Further studies are required to explore the association between DKA at diagnosis and HbA1c over time and to understand the importance of sociodemographic, physiological and other factors.<\/jats:p>\n \n Disclosure<\/jats:title>\n H. Clapin: None. G. J. Smith: None. S. Vijayanand: None. T. Jones: None. E. A. Davis: None. A. Haynes: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db21-929-p","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T22:15:10Z","timestamp":1624572910000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["929-P: A Population-Based Study of Long-Term HbA1c Associated with Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Western Australian Children"],"prefix":"10.2337","volume":"70","author":[{"given":"HELEN","family":"CLAPIN","sequence":"first","affiliation":[{"name":"Nedlands, Australia, Subiaco, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GRANT J.","family":"SMITH","sequence":"additional","affiliation":[{"name":"Nedlands, Australia, Subiaco, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SATHYAKALA","family":"VIJAYANAND","sequence":"additional","affiliation":[{"name":"Nedlands, Australia, Subiaco, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIM","family":"JONES","sequence":"additional","affiliation":[{"name":"Nedlands, Australia, Subiaco, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH A.","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Nedlands, Australia, Subiaco, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AVENI","family":"HAYNES","sequence":"additional","affiliation":[{"name":"Nedlands, Australia, Subiaco, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/929-P\/140422\/929-P-A-Population-Based-Study-of-Long-Term-HbA1c","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/929-P\/140422\/929-P-A-Population-Based-Study-of-Long-Term-HbA1c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T11:48:12Z","timestamp":1647172092000},"score":7.782448,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/929-P\/140422\/929-P-A-Population-Based-Study-of-Long-Term-HbA1c"}},"issued":{"date-parts":[[2021,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db21-929-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2021,6,1]]},"article-number":"929-P"},{"indexed":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T04:15:59Z","timestamp":1686370559732},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"7_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,4,4]]},"abstract":"Abstract<\/jats:title>\n Purpose Patients with melanoma liver metastases have significantly reduced overall response and survival when treated with immune checkpoint inhibitors (ICI) compared to those without liver metastases. Melanoma liver metastases are less likely to respond to ICI compared to other sites of metastases, and the presence of liver metastases has also been associated with reduced responses to ICI at other metastatic sites. We aimed to profile circulating and tumor immune profiles of melanoma patients with versus without liver metastases to elucidate the factors behind this observation.<\/jats:p>\n Methods Pre-treatment PBMCs from 37 advanced melanoma patients (Cohort A) were profiled using mass cytometry (CyTOF) spanning 46 markers. Expression of specific immune cells were compared between those with (n = 8) vs without (n = 29) liver metastases. In a separate independent cohort of 93 untreated metastatic melanoma patients (Cohort B), FFPE tumour samples comprised of subcutaneous, lymph node (LN) and brain metastases were stained for myeloid and T cell markers using multiplex IHC. Immune cell populations in cohort B tissues were compared between patients with (n=40) vs without (n=53) liver metastases.<\/jats:p>\n Results PBMCs from patients in Cohort A with liver metastases had an increased proportion of a myeloid population characterised as HLA-DR+CD14+CD16- compared to patients without liver metastases (p = 0.035). However, a difference in CD68+CD14+CD16- myeloid cells was not seen in cohort B melanoma tissues (subcut, LN, brain metastases) between patients with vs without liver metastases. In subcutaneous tissues, there was a significantly reduced density of T cells in patients with liver metastases (median = 59 cells\/mm2) compared to those without (median = 217 cells\/mm2; p = 0.037). This trend was also observed in LN and brain metastases but did not reach significance. In brain metastases, a higher proportion of FoxP3+ T cells was observed in patients with liver metastases (p = 0.003). An increase in this population was also observed in the LN and subcutaneous metastases in the presence (vs absence) of liver metastases, however this did not reach significance. LN metastases also showed a reduced proportion of both TIM3+ (p = 0.049) and CD103+ (p = 0.048) T cells in patients with liver metastases (vs absence), and a similar trend was observed in subcutaneous metastases. In contrast, brain metastases showed the opposite trend as well as higher proportion of PD1+ T cells in patients with liver metastases vs those without (p = 0.033).<\/jats:p>\n Conclusion These data provide insights into the differences in the anti-tumor immune profiles of patients with versus without liver metastases; the presence of liver metastases may have a specific impact at different metastatic sites. This highlights the need for further validation and investigation into the mechanism by which the presence of liver metastases may exert this effect.<\/jats:p>\n Citation Format: Jordan W. Conway, Felix Marsh-Wakefield, Kazi J. Nahar, Serigne N. Lo, Ismael A. Vergara, Tuba N. Gide, Grace H. Attrill, Jorja Braden, Matteo S. Carlino, Robyn P. Saw, John F. Thompson, Andrew J. Spillane, Kerwin F. Shannon, Brindha Shivalingam, Alexander M. Menzies, Umaimainthan Palendira, James S. Wilmott, Georgina V. Long, Richard A. Scolyer, Ines Pires Da Silva. The association between melanoma liver metastases (mets) and the systemic anti-tumor immune profile [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 81.<\/jats:p>","DOI":"10.1158\/1538-7445.am2023-81","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T20:28:20Z","timestamp":1680640100000},"page":"81-81","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 81: The association between melanoma liver metastases (mets) and the systemic anti-tumor immune profile"],"prefix":"10.1158","volume":"83","author":[{"given":"Jordan W.","family":"Conway","sequence":"first","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Marsh-Wakefield","sequence":"additional","affiliation":[{"name":"2The University of Sydney, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazi J.","family":"Nahar","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serigne N.","family":"Lo","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismael A.","family":"Vergara","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuba N.","family":"Gide","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace H.","family":"Attrill","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorja","family":"Braden","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo S.","family":"Carlino","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn P.","family":"Saw","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Thompson","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Spillane","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerwin F.","family":"Shannon","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brindha","family":"Shivalingam","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander M.","family":"Menzies","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umaimainthan","family":"Palendira","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Wilmott","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina V.","family":"Long","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Scolyer","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines Pires","family":"Da Silva","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/83\/7_Supplement\/81\/720004\/Abstract-81-The-association-between-melanoma-liver","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/83\/7_Supplement\/81\/720004\/Abstract-81-The-association-between-melanoma-liver","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T16:33:53Z","timestamp":1686328433000},"score":7.7817297,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/83\/7_Supplement\/81\/720004\/Abstract-81-The-association-between-melanoma-liver"}},"issued":{"date-parts":[[2023,4,4]]},"references-count":0,"journal-issue":{"issue":"7_Supplement","published-print":{"date-parts":[[2023,4,4]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2023-81","ISSN":["1538-7445"],"issn-type":[{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2023,4,4]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:35:42Z","timestamp":1753889742295,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2021,6,1]]},"abstract":"Studies on how a gluten free (GF) diet in youth with T1D and CD impacts glycemic control, quality of life (QoL) and nutrient intake are limited. The study aim was to determine the effects of the introduction of a GF diet in children with T1D and newly diagnosed CD on glycemic control, nutrient intake, QoL and body mass index (BMI). Subjects wore a continuous glucose monitor for 12 days and completed a 4-day food record at baseline and 3 months after implementing a GF diet. Participants and one parent completed the PedsQL questionnaire at baseline and 3 months. Ten children participated (age 10.8y \u00b1 3.3, 40% male, BMI Z-score 0.5 \u00b1 0.6, diabetes duration 2.2y \u00b1 2.6 (50% with diabetes duration of &lt;12 months), 60% on multiple daily injections, 20% on insulin pump therapy and 20% on twice-daily injections, HbA1c 6.0 \u00b1 1.1%). BMI Z-score (0.4 vs. 0.5, p=0.73), glycemic variability % CV (40.4% vs. 40.2%, p=0.94), HbA1c (6.0% vs. 5.8%, p=0.56), percentage glucose time above target range &gt;180mg\/dL (30.3% vs. 36.1%, p=0.09) and below target range &lt;70mg\/dL (7.2% vs. 7.9%, p=0.76) did not change significantly from baseline to 3-months, however time in range (TIR) 70-180mg\/dL (62.6% vs. 56.0%, p=0.02) was significantly lower at 3 months. Intake of fibre (18g vs. 16g, p=0.40), iron (9g vs. 8g, p=0.35), calcium (826mg vs. 791mg, p=0.75) and saturated fat (13.5% vs. 14.0%, p=0.77) were not significantly different from baseline to 3 months. QoL score was not significantly different for parents (63.2 vs. 67.4, p=0.08) or children (56.8 vs. 63.5, p=0.08) from baseline to 3 months. This study suggests that implementation of a GF diet in children with T1D does not adversely impact glycemic control, nutrient intake, QoL or BMI Z-score. The only change in glycemic control reduced TIR at 3 months which may represent changing insulin requirements with gut healing and the end of the remission phase of T1D.<\/jats:p>\n \n Disclosure<\/jats:title>\n A. L. Marlow: None. B. R. King: None. S. E. Johnson: Consultant; Self; Medtronic. S. K. Binkowski: None. J. Fairchild: None. E. A. Davis: None. C. E. Smart: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Australasian Paediatric Endocrine Group; Pfizer Inc. (WI205278)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db21-502-p","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T22:15:03Z","timestamp":1624572903000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["502-P: Introduction of a Gluten-Free Diet in Children with Type 1 Diabetes and Coeliac Disease Did Not Impact Glycemic Control, Nutrient Intake, or Quality of Life at Three Months"],"prefix":"10.2337","volume":"70","author":[{"given":"ALEXANDRA L.","family":"MARLOW","sequence":"first","affiliation":[{"name":"New Lambton, Australia, Newcastle, Australia, North Adelaide, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRUCE R.","family":"KING","sequence":"additional","affiliation":[{"name":"New Lambton, Australia, Newcastle, Australia, North Adelaide, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHAUN E.","family":"JOHNSON","sequence":"additional","affiliation":[{"name":"New Lambton, Australia, Newcastle, Australia, North Adelaide, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SABRINA K.","family":"BINKOWSKI","sequence":"additional","affiliation":[{"name":"New Lambton, Australia, Newcastle, Australia, North Adelaide, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAN","family":"FAIRCHILD","sequence":"additional","affiliation":[{"name":"New Lambton, Australia, Newcastle, Australia, North Adelaide, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH A.","family":"DAVIS","sequence":"additional","affiliation":[{"name":"New Lambton, Australia, Newcastle, Australia, North Adelaide, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARMEL E.","family":"SMART","sequence":"additional","affiliation":[{"name":"New Lambton, Australia, Newcastle, Australia, North Adelaide, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/502-P\/140084\/502-P-Introduction-of-a-Gluten-Free-Diet-in","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/502-P\/140084\/502-P-Introduction-of-a-Gluten-Free-Diet-in","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T11:45:19Z","timestamp":1647171919000},"score":7.781126,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/502-P\/140084\/502-P-Introduction-of-a-Gluten-Free-Diet-in"}},"issued":{"date-parts":[[2021,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db21-502-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2021,6,1]]},"article-number":"502-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:38:42Z","timestamp":1753889922671,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: Evidence suggests that modulating the gut microbiota during pregnancy through dietary interventions may reduce gestational diabetes mellitus (GDM) risk. To improve acceptability and reduce research waste, co-designing interventions with consumers has emerged as a powerful method of meaningful consumer engagement. This study aimed to co-design the Healthy Gut Diet, a complex dietary behavior change intervention for preventing GDM, with women who had previously experienced GDM.<\/jats:p>\n Methods: Co-design used a range of participatory methods with 6 researchers and 12 consumer participants across 3 online workshops. A 'behavior diagnosis' explored barriers and enablers of two dietary behaviors: increasing plant food intake and reducing ultra-processed food consumption. The COM-B model of behavior, the Theoretical Domains Framework (TDF) and the Behavior Change Wheel were used to select Behavior Change Techniques, embedded in all components of the intervention.<\/jats:p>\n Results: Barriers and enablers were mapped across six COM-B components and 10 TDF domains. Five intervention functions\u2014education, enablement, environmental restructuring, persuasion, and incentivization\u2014were employed, integrating 40 behavior change techniques. The intervention comprises telehealth dietitian sessions, participant handbooks, text messages, and social media support groups.<\/jats:p>\n Conclusion: The Healthy Gut Diet is the result of understanding consumer education and support preferences as well as targeting barriers to changing dietary behavior. This co-design process provided unique insights into what women want and need from dietary interventions with individualization and flexibility being perceived as key factors for success.<\/jats:p>\n \n Disclosure<\/jats:title>\n N.J.L. Meloncelli: None. S. Wilkinson: None. A. Rushton: None. K. Pateman: None. S. Gallaher: None. H.M. O'Connor: None. S.J. de Jersey: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Office of Research and Innovation, Queensland HealthThe University of Queensland, Faculty of Medicine<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-1257-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T06:31:19Z","timestamp":1749796279000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1257-P: Codesigning the Healthy Gut Diet\u2014A Complex Dietary Behavior Change Intervention to Prevent Gestational Diabetes Mellitus"],"prefix":"10.2337","volume":"74","author":[{"given":"NINA J.L.","family":"MELONCELLI","sequence":"first","affiliation":[{"name":"Brisbane, Australia, Herston, Australia, Surry Hills, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHELLEY","family":"WILKINSON","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Herston, Australia, Surry Hills, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALITA","family":"RUSHTON","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Herston, Australia, Surry Hills, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KELSEY","family":"PATEMAN","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Herston, Australia, Surry Hills, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SAMANTHA","family":"GALLAHER","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Herston, Australia, Surry Hills, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HANNAH M.","family":"O'CONNOR","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Herston, Australia, Surry Hills, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUSAN J.","family":"DE JERSEY","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Herston, Australia, Surry Hills, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1257-P\/159908\/1257-P-Codesigning-the-Healthy-Gut-Diet-A-Complex","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1257-P\/159908\/1257-P-Codesigning-the-Healthy-Gut-Diet-A-Complex","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T16:48:59Z","timestamp":1750438139000},"score":7.778591,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1257-P\/159908\/1257-P-Codesigning-the-Healthy-Gut-Diet-A-Complex"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-1257-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"1257-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:35:57Z","timestamp":1753889757493,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Background: There has been a change in the management of type 1 diabetes (T1D) with the availability of continuous glucose monitoring (CGM) systems. In Australia, subsidized CGM is available to patients below the age of 21. A randomized controlled trial (RCT) evaluating hybrid closed loop therapy is currently underway and the baseline data provided an opportunity to analyze the glycemic patterns in patients on contemporary management.<\/jats:p>\n Methods: Adolescents and young adults with T1D and HbA1c &lt;10.5% were eligible. All participants wore masked CGM (Enlite\u00ae Sensor 3, Medtronic) for 3 weeks during the run-in period. Glucose data from masked CGM were evaluated for glycemic patterns including sensor glucose (SG), glucose variability, percentage time in range, time in hypoglycemia and hyperglycemia.<\/jats:p>\n Results: Data were analyzed from 100 participants (47M, 53F; pump 80, MDI 20) with (mean\u00b1SD) age 14.9\u00b12.7 years, diabetes duration 7.6\u00b10.9 years, HbA1c 7.9\u00b10.9% of which 55% participants were on real-time CGM. The (mean\u00b1SD) SG was 9.6\u00b11.6mmol\/l with fasting SG of 8.8\u00b11.9mmol\/l. The SG coefficient of variation was 41.3\u00b16.04%. The median [IQR] %time in range (3.9 to 10mmol\/l) was 55.9 [44.1,62.3]. The %time in hypoglycemia (&lt;3.0 and &lt; 3.9mmol\/l) were 1.1[0.3,2.2] and 4.4[2.2,8.6] respectively. The %time in hyperglycemia (&gt;10 and &gt;13.9mmol\/l) were 35.5[24.7,45.7] and 14.1[8.1,18.8] respectively.<\/jats:p>\n Conclusion: Majority of adolescents in the trial were on insulin pump therapy with half of them on CGM. The baseline CGM data of these participants provide a snapshot of the glycemic management in patients with T1D on current therapy; especially highlighting the reduced time in hypoglycemia compared to earlier trials. The data can further inform the conduct of future trials.<\/jats:p>\n \n Disclosure<\/jats:title>\n M.B. Abraham: None. G.J. Smith: None. M. de Bock: None. B.R. King: None. J. Fairchild: None. G. Ambler: None. F. Cameron: None. E.A. Davis: None. D.N. ONeal: None. T. Jones: Research Support; Self; Dexcom, Inc., Medtronic MiniMed, Inc. Speaker's Bureau; Self; Eli Lilly and Company, Roche Diabetes Care.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-2407-pub","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T02:29:34Z","timestamp":1559701774000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["2407-PUB: Glycemic Patterns Derived from Masked Continuous Glucose Monitoring in Adolescents with Type 1 Diabetes on Contemporary Management"],"prefix":"10.2337","volume":"68","author":[{"given":"MARY B.","family":"ABRAHAM","sequence":"first","affiliation":[{"name":"Perth, Australia, Christchurch, New Zealand, Newcastle, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GRANT J.","family":"SMITH","sequence":"additional","affiliation":[{"name":"Perth, Australia, Christchurch, New Zealand, Newcastle, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTIN DE","family":"BOCK","sequence":"additional","affiliation":[{"name":"Perth, Australia, Christchurch, New Zealand, Newcastle, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRUCE R.","family":"KING","sequence":"additional","affiliation":[{"name":"Perth, Australia, Christchurch, New Zealand, Newcastle, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAN","family":"FAIRCHILD","sequence":"additional","affiliation":[{"name":"Perth, Australia, Christchurch, New Zealand, Newcastle, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GEOFFREY","family":"AMBLER","sequence":"additional","affiliation":[{"name":"Perth, Australia, Christchurch, New Zealand, Newcastle, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FERGUS","family":"CAMERON","sequence":"additional","affiliation":[{"name":"Perth, Australia, Christchurch, New Zealand, Newcastle, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH A.","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Perth, Australia, Christchurch, New Zealand, Newcastle, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"ONEAL","sequence":"additional","affiliation":[{"name":"Perth, Australia, Christchurch, New Zealand, Newcastle, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIMOTHY","family":"JONES","sequence":"additional","affiliation":[{"name":"Perth, Australia, Christchurch, New Zealand, Newcastle, Australia, North Adelaide, Australia, Westmead, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/2407-PUB\/60393\/2407-PUB-Glycemic-Patterns-Derived-from-Masked","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/2407-PUB\/60393\/2407-PUB-Glycemic-Patterns-Derived-from-Masked","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:10:56Z","timestamp":1647166256000},"score":7.776372,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/2407-PUB\/60393\/2407-PUB-Glycemic-Patterns-Derived-from-Masked"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-2407-pub","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"2407-PUB"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:39:19Z","timestamp":1753889959715,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Diabetic vascular complications are characterized by impaired angiogenic responses to ischemia, resulting in delayed healing following tissue injury. MicroRNAs (miRNAs), small non-coding RNAs that target gene expression, regulate angiogenesis in a time-dependent manner. Using a miRNA array approach, we discovered that miR-181c was regulated by angiogenic stimuli but had no previous reported role in diabetes. We sought to elucidate the role of miR-181c in diabetes-impaired angiogenesis. We found that miR-181c was inhibited in endothelial cells (ECs) exposed to hypoxia but were, conversely, elevated in high glucose. To assess the importance of miR-181c in angiogenesis, ECs were transfected with mimics or antimiRs to mimic or suppress miR-181c activity respectively. Cells with increased miR-181c activity had a reduced capacity to form tubules and lower VEGFA protein levels. Conversely, suppression of miR-181c activity augmented tubule formation and VEGFA expression. This suggests that miR-181c plays an inhibitory role in angiogenesis, at least in part, through VEGFA regulation. In vivo, miR-181c was temporally tracked following ischemic induction in the hindlimb. Early post-ischemia, when angiogenesis is important, diabetic mice had elevated miR-181c levels compared to nondiabetic controls. However, at later timepoints, miR-181c levels dropped to levels similar to nondiabetic mice. This indicates that miR-181c suppression may be critical to facilitate early responses to ischemia. Diabetic mice were injected with antimiR-181c or antimiR-Neg to determine if miR-181c knockdown rescues diabetes-impaired angiogenesis. Inhibition of miR-181c completely rescued diabetes-impaired blood flow reperfusion, restoring it back to that of nondiabetic levels. Taken together, this study has identified that miR-181c plays a key role in the regulation of angiogenesis in ischemia and in diabetes. This highlights a potential new therapeutic approach for the treatment of diabetic vascular complications.<\/jats:p>\n \n Disclosure<\/jats:title>\n E. Solly: None. S.T. Hourigan: None. J. Mulangala: None. P.J. Psaltis: None. B. Di Bartolo: None. M. Ng: None. S. Nicholls: Consultant; Self; Amgen Inc., AstraZeneca, Boehringer Ingelheim International GmbH, Cerenis, CSL Behring, Eli Lilly and Company, Merck Sharp & Dohme Corp., Novo Nordisk Inc., Omthera, Pfizer Inc., Resverlogix Corp., Roche Pharma, Sanofi, Takeda Pharmaceutical Company Limited. Research Support; Self; Amgen Inc., AstraZeneca, Athernova, Cerenis, Eli Lilly and Company, InfraReDx, Novartis Pharmaceuticals Corporation, Resverlogix Corp., Sanofi. C. Bursill: None. J.T.M. Tan: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Diabetes Australia<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-425-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T02:58:13Z","timestamp":1559703493000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["425-P: Inhibition of miR-181c Rescues Diabetes-Impaired Angiogenesis"],"prefix":"10.2337","volume":"68","author":[{"given":"EMMA","family":"SOLLY","sequence":"first","affiliation":[{"name":"Adelaide, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SAMUEL T.","family":"HOURIGAN","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOCELYNE","family":"MULANGALA","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER J.","family":"PSALTIS","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BELINDA DI","family":"BARTOLO","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTIN","family":"NG","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN","family":"NICHOLLS","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTINA","family":"BURSILL","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOANNE T.M.","family":"TAN","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/425-P\/60519\/425-P-Inhibition-of-miR-181c-Rescues-Diabetes","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/425-P\/60519\/425-P-Inhibition-of-miR-181c-Rescues-Diabetes","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:12:36Z","timestamp":1647166356000},"score":7.7721686,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/425-P\/60519\/425-P-Inhibition-of-miR-181c-Rescues-Diabetes"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-425-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"425-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:42:00Z","timestamp":1753890120416,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,6,14]]},"abstract":"Insulin resistance is a cardiovascular (CV) risk factor in type 1 diabetes (T1D). The effect of metformin on liver and muscle insulin resistance has not been studied in adults with T1D. We recruited 40 adults with T1D (HbA1c 7.5\u00b10.9% [58\u00b110mmol\/mol], diabetes duration 22.9\u00b18.9 years, age 37.4\u00b18.8 years, 60% male, BMI 26.4\u00b13.8 kg\/m2). Twenty age, gender and BMI matched controls without diabetes were studied at baseline only. Subjects with T1D were randomized to metformin XR 1500mg daily or placebo for 26 weeks. At baseline and end of treatment, subjects completed two-step hyperinsulinemic-euglycemic clamps with 6,6-2H2 glucose to measure insulin sensitivity at liver (endogenous glucose production during low dose insulin infusion; EGP) and muscle (glucose infusion rate during high dose insulin infusion; GIR). Arterial stiffness (augmentation index; AIx), body composition (DXA, MRI), continuous glucose monitoring (CGM) and growth differentiation factor 15 (GDF15) were measured. Adults with T1D displayed insulin resistance in muscle (GIR 29% lower) and liver (EGP 64% higher). After 26 weeks, metformin reduced total daily insulin dose (estimated treatment difference [ETD] -6.5 units\/day [95% CI -11.4 to -1.7]; p=0.009) and visceral fat (p=0.04), and increased serum GDF15 levels (ETD 382 pg\/mL [59 to 704]; p&lt;0.001). Metformin did not improve EGP, GIR, AIx, body composition, HbA1c or CGM time in range vs placebo. Metformin reduced insulin dose and visceral fat, and increased GDF15, without improving insulin resistance. This insulin dose difference was previously associated with a 6% CV risk difference. This study: 1) Implicates insulin resistance-independent actions of metformin; 2) Highlights reducing insulin dose as a possible mediator of metformin\u2019s cardioprotection; and 3) Postulates that metformin\u2019s effects in adults with T1D may involve GDF15.<\/jats:p>\n \n Disclosure<\/jats:title>\n J.R. Snaith: None. N.D. Olsen: Stock\/Shareholder; Pfizer Inc. G.M. Kowalski: None. C. Bruce: None. J.L. Evans: None. A.S. Januszewski: None. A. Jenkins: Research Support; Abbott, Viatris Inc. Advisory Panel; Abbott. Research Support; Medtronic. Board Member; Insulin for Life. Research Support; Leona M. and Harry B. Helmsley Charitable Trust, Juvenile Diabetes Research Foundation (JDRF), Jaeb Center for Health Research, National Institutes of Health, National Health and Medical Research Council Australia. S.N. Breit: Other Relationship; Novo Nordisk A\/S, Aveo Pharmaceutical, Roche Diagnostics. J. Holmes-Walker: None. J. Greenfield: Other Relationship; Novo Nordisk.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Diabetes Australia; St Vincent's Clinic Foundation; UNSW Cardiac, Vascular and Metabolic Medicine Theme; National Health and Medical Research Council (NHMRC)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db24-865-p","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:16:18Z","timestamp":1718349378000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["865-P: Metformin Reduces Insulin Dose and Visceral Fat Accumulation, and Increases GDF15 without Reducing Insulin Resistance in Adults with Type 1 Diabetes\u2014A 26-Week, Randomized, Double-Blind Placebo-Controlled Trial (INTIMET)"],"prefix":"10.2337","volume":"73","author":[{"given":"JENNIFER R.","family":"SNAITH","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Sydney NSW, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NICHOLAS D.","family":"OLSEN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Sydney NSW, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GREG M.","family":"KOWALSKI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Sydney NSW, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CLINTON","family":"BRUCE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Sydney NSW, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENNIFER L.","family":"EVANS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Sydney NSW, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Sydney NSW, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Sydney NSW, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SAMUEL N.","family":"BREIT","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Sydney NSW, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANE","family":"HOLMES-WALKER","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Sydney NSW, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JERRY","family":"GREENFIELD","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Sydney NSW, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/865-P\/156513\/865-P-Metformin-Reduces-Insulin-Dose-and-Visceral","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/865-P\/156513\/865-P-Metformin-Reduces-Insulin-Dose-and-Visceral","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:16:18Z","timestamp":1718349378000},"score":7.7714305,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/865-P\/156513\/865-P-Metformin-Reduces-Insulin-Dose-and-Visceral"}},"issued":{"date-parts":[[2024,6,14]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2024,6,14]]}},"URL":"https:\/\/doi.org\/10.2337\/db24-865-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2024,6,14]]},"article-number":"865-P"},{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:53:28Z","timestamp":1782867208321,"version":"3.54.5"},"publisher-location":"Reston, VA","reference-count":0,"publisher":"American Society of Civil Engineers","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2017,7,6]]},"DOI":"10.1061\/9780784480779.132","type":"proceedings-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T11:01:04Z","timestamp":1499338864000},"page":"1061-1068","source":"Crossref","is-referenced-by-count":6,"title":["A Bounding Surface Plasticity Model for Unsaturated Soils Accounting for the Void Ratio Dependency of the Water Retention Curve"],"prefix":"10.1061","author":[{"given":"H.","family":"Moghaddasi","sequence":"first","affiliation":[{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Alipour","family":"Esgandani","sequence":"additional","affiliation":[{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Khoshghalb","sequence":"additional","affiliation":[{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Shahbodagh-Khan","sequence":"additional","affiliation":[{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Khalili","sequence":"additional","affiliation":[{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30","published-online":{"date-parts":[[2017,7,6]]},"event":{"name":"Sixth Biot Conference on Poromechanics","location":"Paris, France"},"container-title":["Poromechanics VI"],"link":[{"URL":"https:\/\/ascelibrary.org\/doi\/pdf\/10.1061\/9780784480779.132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:10:18Z","timestamp":1782864618000},"score":7.771019,"resource":{"primary":{"URL":"https:\/\/ascelibrary.org\/doi\/10.1061\/9780784480779.132"}},"issued":{"date-parts":[[2017,7,6]]},"references-count":0,"alternative-id":["10.1061\/9780784480779.132","10.1061\/9780784480779"],"URL":"https:\/\/doi.org\/10.1061\/9780784480779.132","published":{"date-parts":[[2017,7,6]]}},{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:55:29Z","timestamp":1782867329602,"version":"3.54.5"},"publisher-location":"Reston, VA","reference-count":0,"publisher":"American Society of Civil Engineers","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2017,7,6]]},"DOI":"10.1061\/9780784480779.121","type":"proceedings-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T11:01:04Z","timestamp":1499338864000},"page":"972-979","source":"Crossref","is-referenced-by-count":2,"title":["A 3D Bounding Surface Plasticity Model for Soils"],"prefix":"10.1061","author":[{"given":"Golnaz Alipour","family":"Esgandani","sequence":"first","affiliation":[{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Moghaddasi","sequence":"additional","affiliation":[{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Shahbodagh-Khan","sequence":"additional","affiliation":[{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Khoshghalb","sequence":"additional","affiliation":[{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Khalili","sequence":"additional","affiliation":[{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30","published-online":{"date-parts":[[2017,7,6]]},"event":{"name":"Sixth Biot Conference on Poromechanics","location":"Paris, France"},"container-title":["Poromechanics VI"],"link":[{"URL":"https:\/\/ascelibrary.org\/doi\/pdf\/10.1061\/9780784480779.121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:10:15Z","timestamp":1782864615000},"score":7.769015,"resource":{"primary":{"URL":"https:\/\/ascelibrary.org\/doi\/10.1061\/9780784480779.121"}},"issued":{"date-parts":[[2017,7,6]]},"references-count":0,"alternative-id":["10.1061\/9780784480779.121","10.1061\/9780784480779"],"URL":"https:\/\/doi.org\/10.1061\/9780784480779.121","published":{"date-parts":[[2017,7,6]]}},{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:59:41Z","timestamp":1768255181720,"version":"3.49.0"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: Exercise increases hypoglycemia risk in people with T1D. Pre exercise whey protein ingestion, which stimulates glucagon secretion and endogenous glucose production, may be a novel strategy to mitigate hypoglycemia with exercise in T1D.<\/jats:p>\n Methods: Three adults with T1D (mean \u00b1 SD HbA1c 6.6 \u00b1 0.3%) using MiniMed 780G underwent two bouts of moderate intensity continuous cycling in the afternoon (60min at 50% VO2max). A standard meal was ingested 4 hours prior and a temporary target set 2 hours pre-exercise. In random order water (control) or whey protein (0.5g\/kg) was ingested 30min pre-exercise.<\/jats:p>\n Results: Protein ingestion resulted in a diminished exercise associated fall in glucose from exercise onset to end of exercise (-9.6 \u00b1 7.5 vs -55.2 \u00b1 31.6 mg\/dL, mean \u00b1 SD). From exercise onset to 2 hours post exercise, protein vs control resulted in higher mean glucose (118.7 \u00b1 24.5 vs 168.5 \u00b1 34.4 mg\/dL, mean \u00b1 SD), and more time &gt;180mg\/dL (24.3 \u00b1 29.2 vs 1.8 \u00b1 3.1 %, mean \u00b1 SD). There were no instances of hypoglycemia.<\/jats:p>\n Conclusion: Pre exercise whey protein ingestion mitigates the drop in glucose during exercise in people with T1D, although the optimal timing and dose of protein ingestion pre-exercise may need to be optimized.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n D. Morrison: None. L. Agnoletto: None. C. Schofield: None. D.T. Hennessy: None. D.P. Zaharieva: Research Support; Hemsley Charitable Trust. Speaker's Bureau; Dexcom, Inc. Research Support; Insulet Corporation, International Society for Pediatric and Adolescent Diabetes. Y.W. Kong: None. J. Apostolopoulos: None. J. Ngan: None. C.E. Smart: None. C. Bruce: None. G.M. Kowalski: None. D.N. O'Neal: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n The Leona M. & Harry B. Helmsley Charitable Trust Grant (2311-06395)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-573-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T07:15:45Z","timestamp":1749798945000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["573-P: Pre-exercise Whey Protein Ingestion to Mitigate Exercise-Induced Hypoglycemia in Adults with Type 1 Diabetes"],"prefix":"10.2337","volume":"74","author":[{"given":"DALE","family":"MORRISON","sequence":"first","affiliation":[{"name":"Stanford, CA, Parkville, Australia, Newcastle, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUCAS","family":"AGNOLETTO","sequence":"additional","affiliation":[{"name":"Stanford, CA, Parkville, Australia, Newcastle, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARA","family":"SCHOFIELD","sequence":"additional","affiliation":[{"name":"Stanford, CA, Parkville, Australia, Newcastle, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DECLAN T.","family":"HENNESSY","sequence":"additional","affiliation":[{"name":"Stanford, CA, Parkville, Australia, Newcastle, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DESSI P.","family":"ZAHARIEVA","sequence":"additional","affiliation":[{"name":"Stanford, CA, Parkville, Australia, Newcastle, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YEE W.","family":"KONG","sequence":"additional","affiliation":[{"name":"Stanford, CA, Parkville, Australia, Newcastle, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN","family":"APOSTOLOPOULOS","sequence":"additional","affiliation":[{"name":"Stanford, CA, Parkville, Australia, Newcastle, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENNIFER","family":"NGAN","sequence":"additional","affiliation":[{"name":"Stanford, CA, Parkville, Australia, Newcastle, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARMEL E.","family":"SMART","sequence":"additional","affiliation":[{"name":"Stanford, CA, Parkville, Australia, Newcastle, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CLINTON","family":"BRUCE","sequence":"additional","affiliation":[{"name":"Stanford, CA, Parkville, Australia, Newcastle, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GREG M.","family":"KOWALSKI","sequence":"additional","affiliation":[{"name":"Stanford, CA, Parkville, Australia, Newcastle, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Stanford, CA, Parkville, Australia, Newcastle, Australia, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/573-P\/160514\/573-P-Pre-exercise-Whey-Protein-Ingestion-to","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/573-P\/160514\/573-P-Pre-exercise-Whey-Protein-Ingestion-to","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T17:25:39Z","timestamp":1750440339000},"score":7.7689495,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/573-P\/160514\/573-P-Pre-exercise-Whey-Protein-Ingestion-to"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-573-p","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"573-P"},{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:24:18Z","timestamp":1762431858072,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Adipose tissue exosomal miRNAs (exomiRs) serve as a signalling molecule that is involved in conveying intercellular message signalling. In this study, we aimed to profile the adipose tissue exomiRs in patients with normal glucose tolerant (NGT) and gestational diabetes mellitus (GDM). Omentum were obtained from BMI-matched NGT (n=10) and GDM (n=10) women at delivery (&gt;37 weeks gestation). Isolated exosomes were characterised based on size distribution and protein enrichment. Total exosomal RNA was isolated by miRNeasy (Qiagen) according to manufacturer\u2019s instructions. Illumina TrueSeq Small RNA kit was used to construct a small RNA library. Finally, the resulting sequencing FASTQ files were analysed using miRDeep2 to identify both known and novel miRNAs. A selected exomiR mimic was overexpressed in the human primary trophoblast (PHT) cells and its effect on glucose uptake was evaluated using 2-NBDG. We identified a total of 1209 miRNAs with 18 miRNAs were significantly differentially expressed in GDM exosomes. Comparatively, 12 miRNAs were upregulated while 6 were downregulated in the exosomes from GDM pregnancy compared to normal pregnancy. Consequently, has-miR-515-5p was selected to be investigated in further functional studies, following validation of its expression using real-time PCR. The QRT-PCR analysis of placental tissue showed a significant increase in the expression of GDM placenta compared to NGT placenta. In PHT cells, the overexpression of miR-515-5p significantly stimulated the glucose uptake (p&lt;0.0001) compared to control group. The proteomics analysis of miR-515-5p overexpressed PHT cells showed differential expression of proteins that are associated with glycolysis. These findings suggest adipose tissue exosomal miR515-5p mediated placental glucose uptake could contribute to an excessive placental nutrient transfer GDM, which could instigate consequences, such as fetal overgrowth.<\/jats:p>\n \n Disclosure<\/jats:title>\n N. Jayabalan: None. D. Guanzon: None. A. Lai: None. D. McIntyre: Other Relationship; Self; Novo Nordisk A\/S. M. Lappas: None. C. Salomon: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Diabetes Australia; Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico (1170809)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-1972-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:48Z","timestamp":1592238588000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":3,"title":["1972-P: Adipose Tissue\u2013Derived Exosomal MicroRNA Regulates Placental Glucose Uptake in Gestational Diabetes Mellitus Pregnancies"],"prefix":"10.2337","volume":"69","author":[{"given":"NANTHINI","family":"JAYABALAN","sequence":"first","affiliation":[{"name":"Herston, Australia, Brisbane, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATHERIN","family":"SCHOLZ-ROMERO","sequence":"additional","affiliation":[{"name":"Herston, Australia, Brisbane, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DOMINIC","family":"GUANZON","sequence":"additional","affiliation":[{"name":"Herston, Australia, Brisbane, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREW","family":"LAI","sequence":"additional","affiliation":[{"name":"Herston, Australia, Brisbane, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"MCINTYRE","sequence":"additional","affiliation":[{"name":"Herston, Australia, Brisbane, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTHA","family":"LAPPAS","sequence":"additional","affiliation":[{"name":"Herston, Australia, Brisbane, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARLOS","family":"SALOMON","sequence":"additional","affiliation":[{"name":"Herston, Australia, Brisbane, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1972-P\/57421\/1972-P-Adipose-Tissue-Derived-Exosomal-MicroRNA","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1972-P\/57421\/1972-P-Adipose-Tissue-Derived-Exosomal-MicroRNA","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:45:07Z","timestamp":1647164707000},"score":7.7682285,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1972-P\/57421\/1972-P-Adipose-Tissue-Derived-Exosomal-MicroRNA"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-1972-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"1972-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:39:35Z","timestamp":1753889975287,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2022,6,1]]},"abstract":"We evaluated the association between age of onset of type 2 diabetes and the risk for major diabetes complications. We included 1.1 million people with type 2 diabetes from the Australian diabetes registry, followed from 2010-2019. We evaluated the incidence of hospitalization for, or death from, myocardial infarction (MI) , stroke, and heart failure (HF) , and hospitalization for lower extremity amputation (LEA) ; the incidence of end-stage kidney disease (ESKD; including kidney replacement therapy or death from ESKD) ; and all-cause mortality (ACM) . Poisson regression was used to model rates by age of diabetes onset, current age, and diabetes duration. During 6.9 million person-years of follow-up, 72338, 46533, 101023, 20024, 13331, and 203542 MI, stroke, HF, LEA, ESKD, and ACM events occurred, respectively. The risk for all outcomes increased exponentially with diabetes duration (Figure) . The effects of age and duration differed for each: age was the stronger risk factor for MI, stroke, HF, and ACM, while duration was the predominant determinant of ESKD and LEA risk. At a given age, a 10-year younger age of onset was associated with a 1.1-1.5-fold increased risk of stroke and ACM, a 1.5-2-fold increased risk of MI and HF, and a 2-4-fold increased risk of LEA and ESKD. Thus, the increase in prevalence of young-onset type 2 diabetes may shift the burden of diabetes complications in coming decades.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n J.I.Morton: None. P.Lazzarini: None. K.Polkinghorne: None. D.J.Magliano: None. J.E.Shaw: Advisory Panel; Abbott Diagnostics, AstraZeneca, Eli Lilly and Company, Pfizer Inc., Roche Diagnostics, Research Support; AstraZeneca, Boehringer Ingelheim International GmbH, Speaker's Bureau; AstraZeneca, Eli Lilly and Company, Novo Nordisk, Sanofi.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n JIM is supported by an Australian Government Research Training Program (RTP) Scholarship and Monash Graduate Excellence Scholarship. PAL is supported by a National Health and Medical Research Council Early Career Fellowship. DJM is supported by a National Health and Medical Research Council Senior Research Fellowship. JES is supported by a National Health and Medical Research Council Investigator Grant. This work is partially supported by the Victorian Government\u2019s Operational Infrastructure Support Program.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db22-1139-p","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T06:10:44Z","timestamp":1653977444000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1139-P: The Association between Age of Onset of Type 2 Diabetes and the Long-Term Risk for Major Diabetes-Related Complications"],"prefix":"10.2337","volume":"71","author":[{"given":"JEDIDIAH I.","family":"MORTON","sequence":"first","affiliation":[{"name":"Melbourne, Victoria, Australia, Brisbane, Australia, Clayton, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER","family":"LAZZARINI","sequence":"additional","affiliation":[{"name":"Melbourne, Victoria, Australia, Brisbane, Australia, Clayton, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KEVAN","family":"POLKINGHORNE","sequence":"additional","affiliation":[{"name":"Melbourne, Victoria, Australia, Brisbane, Australia, Clayton, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DIANNA J.","family":"MAGLIANO","sequence":"additional","affiliation":[{"name":"Melbourne, Victoria, Australia, Brisbane, Australia, Clayton, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JONATHAN E.","family":"SHAW","sequence":"additional","affiliation":[{"name":"Melbourne, Victoria, Australia, Brisbane, Australia, Clayton, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/1139-P\/146521\/1139-P-The-Association-between-Age-of-Onset-of","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/1139-P\/146521\/1139-P-The-Association-between-Age-of-Onset-of","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T06:10:44Z","timestamp":1653977444000},"score":7.7665033,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/1139-P\/146521\/1139-P-The-Association-between-Age-of-Onset-of"}},"issued":{"date-parts":[[2022,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db22-1139-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2022,6,1]]},"article-number":"1139-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:38:03Z","timestamp":1753889883865,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"In the mid-2000s in Australia, national guidelines were introduced to promote diabetes screening in people aged 40+ years. We have tested whether diabetes screening has increased, and the prevalence of undiagnosed diabetes has decreased since the introduction of these guidelines. \u2019Crossroads\u2019 is a repeat cross-sectional study conducted between 2000-2003 (Crossroads-I) and then 2016-2018 (Crossroads-II) in rural Australia (the Goulburn Valley, Victoria). Households visited were randomly selected, and the same households were then revisited in Crossroads-II, alongside proportionately randomly selected new houses. All adult residents are interviewed face to face by trained research assistants. Questions enquire about diabetes status, occurrence of diabetes screening in last 2 years and primary care utilisation. Randomly selected participants are invited to attend a \u2019clinic\u2019 including a glucose tolerance test. The Crossroads-I cohort (n=3787) was younger and had a higher proportion of male participants than the Crossroads-II cohort (n=1733) (44 \u00b1 17 vs. 53 \u00b1 19 years p&lt;0.0001, 46% vs. 42% male, p&lt;0.0001). The age standardised prevalence of self-reported diabetes (7.0% vs. 5.4%, p&lt;0.05), and age standardised screening rates (56.5% vs. 49.7%, p&lt;0.05) were higher in Crossroads-II than Crossroads-I. Crude undiagnosed diabetes prevalence was also higher in Crossroads-II than Crossroads-I (17\/430 (3.9%) vs. 15\/814 (1.8%) p&lt;0.05). Primary care utilisation was higher in Crossroads-II than I (6.4 vs. 4.7 visits in past 12 months, p&lt;0.0001) and waiting times were shorter (3.0 vs. 3.9 days, p&lt;0.0001). We conclude that diabetes screening has increased in this area in association with improved access to primary care, and guideline changes. Despite this, rates of undiagnosed diabetes have also increased in line with the overall prevalence of diabetes. Additional strategies are required to reduce undiagnosed diabetes rates further.<\/jats:p>\n \n Disclosure<\/jats:title>\n D. Simmons: Speaker's Bureau; Self; Roche Diabetes Care Health and Digital Solutions, AstraZeneca, Novo Nordisk Inc., Medtronic. K. Glenister: None. D.J. Magliano: None. S.J. Wright: None. L. Bourke: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-1515-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:32Z","timestamp":1529693852000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["The Prevalence of Undiagnosed Diabetes Has Not Decreased in Spite of Increased Screening in an Australian Rural Area"],"prefix":"10.2337","volume":"67","author":[{"given":"DAVID","family":"SIMMONS","sequence":"first","affiliation":[{"name":"Campbelltown, Australia, Wangaratta, Australia, Melbourne, Australia, Shepparton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KRISTEN","family":"GLENISTER","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Wangaratta, Australia, Melbourne, Australia, Shepparton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DIANNA J.","family":"MAGLIANO","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Wangaratta, Australia, Melbourne, Australia, Shepparton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SIAN J.","family":"WRIGHT","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Wangaratta, Australia, Melbourne, Australia, Shepparton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LISA","family":"BOURKE","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Wangaratta, Australia, Melbourne, Australia, Shepparton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1515-P\/54680\/The-Prevalence-of-Undiagnosed-Diabetes-Has-Not","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1515-P\/54680\/The-Prevalence-of-Undiagnosed-Diabetes-Has-Not","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:14:16Z","timestamp":1647162856000},"score":7.7651496,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1515-P\/54680\/The-Prevalence-of-Undiagnosed-Diabetes-Has-Not"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-1515-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"1515-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:38:29Z","timestamp":1753889909528,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: Mitochondrial dysfunction contributes to cardiovascular and microvascular disease risks in type 2 diabetes (T2D). This study investigates whether mitochondrial DNA copy number (mtDNA-CN) in whole blood can serve as a biomarker for these complications.<\/jats:p>\n Methods: mtDNA-CN was measured in the DNA extracted from whole blood samples of 497 T2D adults from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial. The relationship of mtDNA-CN with cardiovascular and microvascular complications over 5 years was assessed.<\/jats:p>\n Results: The cohort (29.8 % women, mean(SD) age 62(7) years, HbA1c 7.1(1.4)%) showed no variation in mtDNA-CN by sex. There were no significant associations of mtDNA-CN with traditional risk factors of age, BMI, HbA1c, diabetic duration (P&gt;0.05), but mtDNA-CN correlated with eGFR (Pearson r = 0.117, P = 0.009) and plasma uric acid (Pearson r = -0.114, P = 0.012). mtDNA-CN was not related to new on-trial total CVD events, but inversely associated with new on-trial total microvascular events (Table 1).<\/jats:p>\n Conclusion: Mitochondrial DNA copy number could serve as a biomarker for assessing microvascular disease risk in T2D patients.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n A. Mangani: None. A.S. Januszewski: None. K. Ong: None. H. Francis: None. R.L. O'Connell: None. L. Li: None. D. Sullivan: Other Relationship; Amgen Inc. Research Support; Arrowhead Pharmaceuticals, Inc. Other Relationship; Novartis Pharmaceuticals Corporation, Merck Sharp & Dohme Corp. Research Support; Ionis Pharmaceuticals. R.S. Scott: None. P.G. Colman: None. A. Jenkins: Advisory Panel; Abbott. Speaker's Bureau; GlaxoSmithKline plc. Research Support; Abbott, Metronics, Ypsomed AG, Insulet Corporation, Jaeb Center for Health Research, Endogenex, Hemsley Charitable Trust. Speaker's Bureau; CSL Seqirus. Research Support; AbbVie Inc, National Institutes of Health, Juvenile Diabetes Research Foundation (JDRF). A.C. Keech: Research Support; Abbott, Amgen Inc, ASPEN Australia, Mylan. Speaker's Bureau; Novartis AG, Pfizer Inc. Research Support; Kowa Company, Ltd. Speaker's Bureau; Sanofi. Research Support; AbbVie Inc, Viatris Inc.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Laboratoires Fournier, Dijon, France and the National Health and MedicalResearch Council of Australia (457103, 1024105, 1037786, 1105467, 1121272, 1137071 and 2018537)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-376-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:04:46Z","timestamp":1749791086000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["376-P: The Relationship of Mitochondrial DNA Copy Number with Cardiovascular and Microvascular Complications in Patients with Type 2 Diabetes\u2014A Field Substudy"],"prefix":"10.2337","volume":"74","author":[{"given":"ABUBAKAR","family":"SIDDIQ MANGANI","sequence":"first","affiliation":[{"name":"Sydney NSW, Australia, Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KWOK","family":"LEUNG ONG","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HABIB","family":"FRANCIS","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RACHEL L.","family":"O'CONNELL","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LIPING","family":"LI","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"SULLIVAN","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RUSSELL S.","family":"SCOTT","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER G.","family":"COLMAN","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTHONY C.","family":"KEECH","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Sydney, Australia, Camperdown, Australia, Christchurch, New Zealand, Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/376-P\/158358\/376-P-The-Relationship-of-Mitochondrial-DNA-Copy","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/376-P\/158358\/376-P-The-Relationship-of-Mitochondrial-DNA-Copy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T15:33:51Z","timestamp":1750433631000},"score":7.7644873,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/376-P\/158358\/376-P-The-Relationship-of-Mitochondrial-DNA-Copy"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-376-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"376-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:15Z","timestamp":1753889835296,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"There is increasing evidence that miRNA, which are enriched in small nanovesicles called exosomes, are important regulators of gene expression. In this study, we tested the hypothesis that circulating exosomes from womem with gestational diabetes mellitus (GDM) carry a specific set of miRNAs which regulate genes associated with placental glucose metabolism. Exosomes were isolated from plasma obtained from normal glucose tolerant women (NGT; n=12) and women with GDM (n=12) pregnancies at delivery by differential and buoyant density centrifugation. Exosomal RNA was extracted and an Illumina TrueSeq Small RNA kit was used to construct a small RNA library. Gene target identification and gene ontology analysis for miRNAs was performed using the Ingenuity pathway analysis (IPA). The effect of exosomes on glucose metabolism in placental cells was assessed using a human glucose metabolism array. In plasma, a total of 44 miRNAs were upregulated in exosomes from women with GDM compared to NGT pregnant women (p&lt;0.005). IPA showed that exosomal miRNAs isolated from women with GDM regulates the expression of placental genes associated with the glycolytic pathway including 6-phosphofructokinase and phosphopyruvate hydratase. Interestingly, exosomes from women with GDM increases the expression of placental genes associated with glycolysis and decrease the expression of genes associated with pentose phosphate pathway. After integration of the miRNA and mRNA data, we identified 74 differentially expressed exosomal miRNAs associated with the modulation of 10 potential target mRNAs in placental cells, which are associated with glucose metabolism. This data suggests that circulating exosomes under diabetic conditions might modulate the placental metabolic state to enhance glycogen metabolism in GDM.<\/jats:p>\n \n Disclosure<\/jats:title>\n S. Nair: None. V. Ormazabal: None. N. Jayabalan: None. D. Guanzon: None. A. Lai: None. H. McIntyre: Speaker's Bureau; Self; Novo Nordisk Inc.. Research Support; Self; Danish Diabetes Academy. M. Lappas: None. C. Salomon: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-164-lb","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:32Z","timestamp":1529693852000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["Circulating Exosomal miRNA Signature in Gestational Diabetes Mellitus Influences Glucose Metabolism in Placental Cells"],"prefix":"10.2337","volume":"67","author":[{"given":"SOUMYALEKSHMI","family":"NAIR","sequence":"first","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VALESKA","family":"ORMAZABAL","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NANTHINI","family":"JAYABALAN","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DOMINIC","family":"GUANZON","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREW","family":"LAI","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"DAVID MCINTYRE","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTHA","family":"LAPPAS","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARLOS","family":"SALOMON","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, Herston, Australia, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/164-LB\/54340\/Circulating-Exosomal-miRNA-Signature-in","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/164-LB\/54340\/Circulating-Exosomal-miRNA-Signature-in","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T10:40:07Z","timestamp":1652697607000},"score":7.7623677,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/164-LB\/54340\/Circulating-Exosomal-miRNA-Signature-in"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-164-lb","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"164-LB"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:54Z","timestamp":1753890054552,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: In people with T1D, ingestion of fast-absorbing protein potently stimulates glucagon secretion and can effectively increase endogenous glucose production. The study characterizes the glucose responses to whey protein ingestion in adults with T1D, which will inform future research into using whey protein to manage hypoglycemia.<\/jats:p>\n Methods: Nine adults (5F\/4M) with T1D (Age: 50.22\u00b116.9y; BMI: 26.2\u00b14.1kg\/cm2) on insulin pumps received 3 interventions in random order after an overnight fast: i) water (CON), ii) low-dose protein (LP; 0.25g\/kg), iii) medium-dose protein (MP; 0.5g\/kg); 3 participants received a 4th intervention iv) high-dose protein (HP; 0.75g\/kg). On test days, insulin pumps were replaced with IV insulin. After 4h for subcutaneous insulin wash-out, insulin infusion rate was fixed, the test drink was given, and blood was sampled every 10min for 3h.<\/jats:p>\n Results: Peak increase in glucose and glucose AUC were similar for HP and MP, and were lowest for LP (Fig. 1A). Blood glucose decreased steadily for CON (Fig. 1A). Postprandial plasma glucagon was higher with increasing protein amount, while glucagon remained unchanged from baseline for CON (Fig. 1B).<\/jats:p>\n Conclusion: Whey protein ingestion stimulates glucagon secretion and raises blood glucose in a dose-dependent manner in people with T1D, suggesting a potential use of whey protein to manage hypoglycemia in this population.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n G. Dao: None. S. Zhao: None. G.M. Kowalski: None. C. Bruce: None. C.E. Smart: None. D.P. Zaharieva: Research Support; Hemsley Charitable Trust. Speaker's Bureau; Dexcom, Inc. Research Support; Insulet Corporation, International Society for Pediatric and Adolescent Diabetes. J. Ngan: None. J. Apostolopoulos: None. Y.W. Kong: None. D.N. O'Neal: None. D. Morrison: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Leona M, and Harry B. Helmsley Charitable Trust (grant #2311-06395)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-598-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:25:57Z","timestamp":1749792357000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["598-P: The Glycemic Impact of Whey Protein Ingestion in Adults with Type 1 Diabetes"],"prefix":"10.2337","volume":"74","author":[{"given":"GIANG","family":"DAO","sequence":"first","affiliation":[{"name":"Geelong, Australia, Melbourne, Australia, Newcastle, Australia, Stanford, CA, Parkville, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SAM","family":"ZHAO","sequence":"additional","affiliation":[{"name":"Geelong, Australia, Melbourne, Australia, Newcastle, Australia, Stanford, CA, Parkville, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GREG 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Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534718410464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534718410464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2018.02.1736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:28:56Z","timestamp":1651210136000},"score":7.757759,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2018.02.1736"}},"issued":{"date-parts":[[2018,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1016\/j.juro.2018.02.1736"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2018.02.1736","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2018,4]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:39:12Z","timestamp":1753889952995,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Objective: To document the characteristics and outcomes for patients with malignancies with or without diabetes at a tertiary referral hospital.<\/jats:p>\n Research Design and Methods: Emergency department and hospital discharge data between 1 Jan 2015 and 31 Dec 2017 were used to identify patients with a diagnosis of a malignancy and diabetes. Multivariate Cox-regression models were used to estimate the effect of diabetes on all-cause mortality. A truncated negative binomial regression model was used to assess the impact of diabetes on length of hospital inpatient stay. Prentice, Williams and Peterson Total Time (PWP-TT) models were used to assess the effect of diabetes on number of Emergency Department presentations and inpatient admissions. Results are presented as incidence-rate ratios (IRR) or hazard ratios (HR). These models were adjusted for age, gender, type of malignancy and Charlson comorbidities.<\/jats:p>\n Results: For 7,058 patients identified with malignancies, 1,230(17.4%) were also diagnosed with diabetes. During the three-year study period a diagnosis of diabetes was associated with an increased number of inpatient admissions (adjusted Hazard Ratio (adjHR): 1.14, 95% CI: 1.04, 1.25), increased number of emergency department presentations (adjHR: 1.19, 95% CI: 1.11, 1.28) and length of stay for patients with diabetes (adjIRR: 1.16, 95% C.I: 1.06, 1.28). A co-diagnosis of diabetes was also associated with a 48% increased risk of all-cause mortality (adjHR 1.48, 95% CI: 1.23-1.77).<\/jats:p>\n Conclusions: Patients with diabetes had significantly higher numbers of emergency department presentations, inpatient admissions, length of hospital stay and higher rates of all-cause mortality compared to cancer patients without diabetes. This adverse link between diabetes and health outcomes in patients with malignancies requires further exploration.<\/jats:p>\n \n Disclosure<\/jats:title>\n K.V. Kiburg: None. G. Ward: None. K.M. Steele: None. E.M. Mulrooney: None. M.M. Loh: None. S. McLachlan: None. V. Sundararajan: None. R. MacIsaac: Advisory Panel; Self; AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Novo Nordisk Inc. Speaker's Bureau; Self; AstraZeneca, Novo Nordisk Inc. Other Relationship; Self; AstraZeneca, Novo Nordisk Inc.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Australian Government Research Training Program (to K.V.K.)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-1646-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T01:27:45Z","timestamp":1559698065000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1646-P: The Impact of a Diabetes Codiagnosis on Hospitalisation and Mortality in Patients with Malignancy"],"prefix":"10.2337","volume":"68","author":[{"given":"KATERINA V.","family":"KIBURG","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GLENN","family":"WARD","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATHLEEN M.","family":"STEELE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH M.","family":"MULROONEY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARGARET M.","family":"LOH","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUE-ANNE","family":"MCLACHLAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VIJAYA","family":"SUNDARARAJAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"MACISAAC","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1646-P\/59666\/1646-P-The-Impact-of-a-Diabetes-Codiagnosis-on","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1646-P\/59666\/1646-P-The-Impact-of-a-Diabetes-Codiagnosis-on","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:05:06Z","timestamp":1647165906000},"score":7.752053,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1646-P\/59666\/1646-P-The-Impact-of-a-Diabetes-Codiagnosis-on"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-1646-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"1646-P"},{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:10:23Z","timestamp":1788869423411,"version":"build-2803163510"},"reference-count":53,"publisher":"Association for Computing Machinery (ACM)","issue":"6","license":[{"start":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T00:00:00Z","timestamp":1421193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"funder":[{"DOI":"10.13039\/100018237","name":"Asian Office of Aerospace Research & Development","doi-asserted-by":"crossref","award":["FA2386-14-1-0007 AOARD 134144, and FA2386-14-1-0022 AOARD 134131"],"award-info":[{"award-number":["FA2386-14-1-0007 AOARD 134144, and FA2386-14-1-0022 AOARD 134131"]}],"id":[{"id":"10.13039\/100018237","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":["ACM Trans. Comput.-Hum. Interact."],"published-print":{"date-parts":[[2015,1,14]]},"abstract":"This article presents a framework of adaptive, measurable decision making for Multiple Attribute Decision Making (MADM) by varying decision factors in their types, numbers, and values. Under this framework, decision making is measured using physiological sensors such as Galvanic Skin Response (GSR) and eye-tracking while users are subjected to varying decision quality and difficulty levels. Following this quantifiable decision making, users are allowed to refine several decision factors in order to make decisions of high quality and with low difficulty levels. A case study of driving route selection is used to set up an experiment to test our hypotheses. In this study, GSR features exhibit the best performance in indexing decision quality. These results can be used to guide the design of intelligent user interfaces for decision-related applications in HCI that can adapt to user behavior and decision-making performance.<\/jats:p>","DOI":"10.1145\/2687924","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T09:29:58Z","timestamp":1421400598000},"page":"1-23","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":43,"title":["Measurable Decision Making with GSR and Pupillary Analysis for Intelligent User Interface"],"prefix":"10.1145","volume":"21","author":[{"given":"Jianlong","family":"Zhou","sequence":"first","affiliation":[{"name":"National ICT Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjun","family":"Sun","sequence":"additional","affiliation":[{"name":"National ICT Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"National ICT Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"National ICT Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie","family":"Taib","sequence":"additional","affiliation":[{"name":"National ICT Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Khawaji","sequence":"additional","affiliation":[{"name":"National ICT Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidong","family":"Li","sequence":"additional","affiliation":[{"name":"National ICT Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"320","published-online":{"date-parts":[[2015,1,14]]},"reference":[{"key":"e_1_2_1_1_1","first-page":"46","article-title":"Models of commuters\u2019 information use and route choice: Initial results based on Southern California Commuter Route Choice Survey","volume":"1453","author":"Abdel-Aty M. 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Retrieved September 20, 2013 from http:\/\/news.xerox.com\/news\/Xerox-researchers-create-new-transportation-applications."},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1145\/1979742.1979819"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1109\/21.310529"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.artint.2013.09.003"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1109\/ICCSEE.2012.1"}],"container-title":["ACM Transactions on Computer-Human Interaction"],"language":"en","link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/2687924","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/2687924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T02:12:14Z","timestamp":1750212734000},"score":7.749833,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/2687924"}},"issued":{"date-parts":[[2015,1,14]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,1,14]]}},"alternative-id":["10.1145\/2687924"],"URL":"https:\/\/doi.org\/10.1145\/2687924","ISSN":["1073-0516","1557-7325"],"issn-type":[{"value":"1073-0516","type":"print"},{"value":"1557-7325","type":"electronic"}],"published":{"date-parts":[[2015,1,14]]},"assertion":[{"value":"2013-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:42Z","timestamp":1753889862341,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"Aim: To examine the potential negative and positive impacts of, and reaction to, eight Australian National Diabetes Week campaign videos (originally broadcast between 2005 and 2015) among adults with and without diabetes.<\/jats:p>\n Method: Cross-sectional, quasi-experimental, 10-arm online study. A general population sample (n=1023, aged 41\u00b114 years, 60% women) and a diabetes population sample (n=510, aged 52\u00b112 years, 49% women, 78% type 2 diabetes) were recruited via an Australian research panel. Participants were randomly exposed to one of eight diabetes campaign videos (intervention) or allocated to one of two control groups (active or passive). Post-exposure, study-specific scales measured diabetes Misconceptions and Seriousness, General and Diabetes Risk-Reduction Motivation and Self-efficacy, and perceptions of video Stigmatization of diabetes. Scores were compared by condition (intervention vs. control), and by campaign Stigma (high vs. low), separately by cohort (general and diabetes).<\/jats:p>\n Results: Exposure to diabetes campaigns had no significant impact on diabetes perceptions, relative to control, with one exception: a modest effect on General Self-efficacy among the general cohort only (p=0.015; d=-0.19). Those perceiving high campaign Stigma (15%), relative to low Stigma (60%), reported significantly greater diabetes Misconceptions (general: d=1.5; diabetes: d=-1.9) and lower Seriousness (d=0.5; d=0.3), as well as lower General Motivation (d=0.2) but higher Diabetes Risk Reduction Motivation (d=0.3) for the general cohort only.<\/jats:p>\n Conclusion: Single exposure to diabetes campaign videos had seemingly little positive impact on public perceptions. The minority, who perceive them as stigmatising, have greater misconceptions about diabetes, and perceive diabetes as less serious. This novel study has implications for the design and evaluation of future diabetes campaign videos globally.<\/jats:p>\n \n Disclosure<\/jats:title>\n E.Holmes-truscott: Research Support; Sanofi, AstraZeneca. J.Hateley-browne: None. E.M.Charalambakis: None. A.D.Ventura: None. A.G.Glenister: None. R.Scibilia: Advisory Panel; Ascensia Diabetes Care, Eli Lilly and Company, Roche Diagnostics, Employee; Diabetes Australia, Speaker's Bureau; diaTribe. J.Speight: Research Support; Sanofi, Medtronic, Abbott Diabetes, Lilly, Novo Nordisk A\/S, Speaker's Bureau; Sanofi.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Diabetes Victoria<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-648-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:27:53Z","timestamp":1687242473000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["648-P: Perceptions of Diabetes and Stigma\u2014A Quasi-Experimental, Cross-Sectional Evaluation of Australian Diabetes Campaign Videos"],"prefix":"10.2337","volume":"72","author":[{"given":"ELIZABETH","family":"HOLMES-TRUSCOTT","sequence":"first","affiliation":[{"name":"Geelong, Australia, Burwood, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JESSICA","family":"HATELEY-BROWNE","sequence":"additional","affiliation":[{"name":"Geelong, Australia, Burwood, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH M.","family":"CHARALAMBAKIS","sequence":"additional","affiliation":[{"name":"Geelong, Australia, Burwood, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ADRIANA D.","family":"VENTURA","sequence":"additional","affiliation":[{"name":"Geelong, Australia, Burwood, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANNETTE G.","family":"GLENISTER","sequence":"additional","affiliation":[{"name":"Geelong, Australia, Burwood, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RENZA","family":"SCIBILIA","sequence":"additional","affiliation":[{"name":"Geelong, Australia, Burwood, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANE","family":"SPEIGHT","sequence":"additional","affiliation":[{"name":"Geelong, Australia, Burwood, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/648-P\/150787\/648-P-Perceptions-of-Diabetes-and-Stigma-A-Quasi","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/648-P\/150787\/648-P-Perceptions-of-Diabetes-and-Stigma-A-Quasi","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:27:53Z","timestamp":1687242473000},"score":7.749343,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/648-P\/150787\/648-P-Perceptions-of-Diabetes-and-Stigma-A-Quasi"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-648-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"648-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:46Z","timestamp":1753889866356,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,6,14]]},"abstract":"Background and Aims: Impaired insulin sensitivity in type 1 diabetes (T1D) is an under-appreciated cardiovascular risk factor yet is challenging to measure. Euglycemic hyperinsulinemic clamps are the \u201cgold standard\u201d for quantifying insulin sensitivity. Adding stable isotope-labeled glucose allows for differentiation of hepatic and muscle insulin sensitivity (assessed by endogenous glucose production [EGP] and glucose infusion rate [GIR] respectively). Non-invasive estimation of both EGP and GIR using biomarkers has not been previously assessed in T1D.<\/jats:p>\n Methods: Two-step clamps were conducted in 40 adults with T1D in the INTIMET trial (INsulin resistance in Type 1 diabetes managed with METformin, ACTRN12619001440112). Subjects were characterized with 33 clinical and research biomarkers. Exhaustive search (XLStat, Lumivero, Denver, CO) was used to derive equations correlating with baseline clamp-quantified EGP and GIR.<\/jats:p>\n Results: Exhaustive search analyses derived a formula predicting unfavorable GIR (dichotomous variable: below median of 60.4 \u00b5mol\/kgFFM\/min) using: total daily insulin dose (TDI), fasting triglycerides (TG), insulin-like growth factor-1 and aspartate aminotransferase (AST) levels, with an AUROC of 0.97, p&lt;0.0001, R2 (Nagelkerke)=0.78, 92.5% accuracy. A model predicting unfavorable EGP level (above median of 6.2 \u00b5mol\/kgFFM\/min) contained four variables: TDI, TG, alkaline phosphatase and uric acid levels, with an AUROC of 0.86, p=0.001, R2 (Nagelkerke) of 0.47, 80% accuracy. Our free online calculator (available at https:\/\/bit.ly\/EGP-GIR-calculator) enables estimation of GIR and EGP by these binary categories.<\/jats:p>\n Conclusions: Tissue specific estimation of insulin sensitivity is feasible in T1D using clinical and research biomarkers. Incorporating estimates of hepatic and muscle insulin sensitivity in clinical trials may predict response to lifestyle and drug interventions. Validation studies are merited.<\/jats:p>\n \n Disclosure<\/jats:title>\n A.S. Januszewski: None. J.R. Snaith: None. G.M. Kowalski: None. C. Bruce: None. J. Holmes-Walker: None. A. Jenkins: Research Support; Abbott, Viatris Inc. Advisory Panel; Abbott. Research Support; Medtronic. Board Member; Insulin for Life. Research Support; Leona M. and Harry B. Helmsley Charitable Trust, Juvenile Diabetes Research Foundation (JDRF), Jaeb Center for Health Research, National Institutes of Health, National Health and Medical Research Council Australia. J. Greenfield: Other Relationship; Novo Nordisk.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db24-1607-p","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T05:16:33Z","timestamp":1718342193000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1607-P: Estimation of Muscle and Hepatic Insulin Sensitivity in Type 1 Diabetes Adults Using Clinical and Research Biomarkers"],"prefix":"10.2337","volume":"73","author":[{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"first","affiliation":[{"name":"Sydney NSW, Australia, Darlinghurst, Australia, Melbourne, Australia, Westmead, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENNIFER R.","family":"SNAITH","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Darlinghurst, Australia, Melbourne, Australia, Westmead, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GREG M.","family":"KOWALSKI","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Darlinghurst, Australia, Melbourne, Australia, Westmead, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CLINTON","family":"BRUCE","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Darlinghurst, Australia, Melbourne, Australia, Westmead, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANE","family":"HOLMES-WALKER","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Darlinghurst, Australia, Melbourne, Australia, Westmead, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Darlinghurst, Australia, Melbourne, Australia, Westmead, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JERRY","family":"GREENFIELD","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Darlinghurst, Australia, Melbourne, Australia, Westmead, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/1607-P\/155235\/1607-P-Estimation-of-Muscle-and-Hepatic-Insulin","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/1607-P\/155235\/1607-P-Estimation-of-Muscle-and-Hepatic-Insulin","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T05:16:33Z","timestamp":1718342193000},"score":7.747927,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/1607-P\/155235\/1607-P-Estimation-of-Muscle-and-Hepatic-Insulin"}},"issued":{"date-parts":[[2024,6,14]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2024,6,14]]}},"URL":"https:\/\/doi.org\/10.2337\/db24-1607-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2024,6,14]]},"article-number":"1607-P"},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T06:42:46Z","timestamp":1651214566184},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.juro.2018.02.2600","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T12:45:58Z","timestamp":1522759558000},"source":"Crossref","is-referenced-by-count":0,"title":["MP77-12\n 68<\/sup>\n GA-PSMA PET\/CT VERSUS MPMRI FOR LOCOREGIONAL PROSTATE CANCER STAGING: CORRELATION WITH FINAL HISTOPATHOLOGY"],"prefix":"10.1097","volume":"199","author":[{"given":"Israel","family":"Berger","sequence":"first","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra","family":"Annabattula","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Lewis","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa","family":"Shetty","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Kam","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Maclean","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan","family":"Arianayagam","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertram","family":"Canagasingham","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Khadra","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Ko","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Winter","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Loh","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celi","family":"Varol","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002253471841912X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002253471841912X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2018.02.2600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T06:10:49Z","timestamp":1651212649000},"score":7.747226,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2018.02.2600"}},"issued":{"date-parts":[[2018,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1016\/j.juro.2018.02.2600"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2018.02.2600","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2018,4]]}},{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:05:31Z","timestamp":1766138731539,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,6,14]]},"abstract":"Aim: To compare maternal glycemia and pregnancy outcomes with treatment initiation before 20 weeks\u2019 versus after 24 weeks' gestation among women with early gestational diabetes mellitus (EGDM).<\/jats:p>\n Methods: This prospective study included participants enrolled in the Treatment of Booking Gestational Diabetes Mellitus randomized controlled trial. Women diagnosed with GDM were provided with an Accu-Chek Guide glucose meter and instructed to monitor capillary blood glucose (BG) 4 times\/day (fasting and 2-h post-prandial). Optimal glycemia was defined as 95% of BG measurements between 3.5 and 7.8 mmol\/l. Pregnancy complications comprised a composite of preterm birth, macrosomia, birth trauma, respiratory distress, phototherapy, stillbirth\/neonatal death, and\/or shoulder dystocia.<\/jats:p>\n Results: 120,677 BG values (mean n=302, 13.2\u00b16.9 weeks\u2019 duration) were obtained from 399 women (mean age 32.4\u00b14.9 years, BMI 31.4\u00b17.8 kg\/m2, 36% European, gestation at GDM diagnosis 15.2\u00b12.4 weeks\u2019). Optimal glycemia was achieved in 72% of women; associated with reduced complications (&gt;95% BGs optimal: 23.6%, 90-95% optimal: 31.3%, &lt;90% optimal: 45.5%; p=0.007). Complications were less in women with lower mean fasting glucose (MFG) (&lt;5.0 mmol\/l: 17.1%, 5.0-5.2 mmol\/l: 30.9%, 5.3-5.5 mmol\/l: 25.6%, &gt;5.6 mmol\/l: 41.7%; p=0.009). Women with EGDM treated early (n=213) showed lower mean glucose (MG) and MFG compared with those treated late (n=116) (MG: 5.7\u00b10.4 vs. 5.9\u00b10.5, p&lt;0.001, MFG: 5.2\u00b10.3 vs. 5.3\u00b10.4; p=0.004), with greater optimal glycemia (95.9% vs. 93.8%, respectively; p=0.04). Similar findings were seen in the second and third trimesters.<\/jats:p>\n Conclusion: Early initiation of treatment in women with EGDM can improve subsequent maternal glycemia and reduce adverse pregnancy outcomes.<\/jats:p>\n \n Disclosure<\/jats:title>\n J. Immanuel: None. W. Hague: None. A. Sweeting: None. V.W.M. Wong: None. E. Hibbert: None. E.J. Gianatti: None. M.J. Peek: None. H. Teede: None. V. Mohan: None. N. Cheung: None. C.J. Nolan: None. A. Kautzky-Willer: None. J. Harreiter: None. H.E. Backman: None. D. Simmons: Speaker's Bureau; Abbott. Consultant; Sanofi. Speaker's Bureau; Ascensia Diabetes Care. Other Relationship; Ascensia Diabetes Care, Boehringer-Ingelheim. Research Support; Dexcom, Inc. Speaker's Bureau; Novo Nordisk. Research Support; Wests Club, NSW, Australia, Roche Diabetes Care.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Health and Medical Research Council (NHMRC) (grants 1104231 and 2009326); Region \u00d6rebro Research Committee Dnr OLL-970566, OLL-942177; Medical Scientific Fund of the Mayor of Vienna, project 15205; South Western Sydney Local Health District Academic Unit grant 2016; Western Sydney University Ainsworth Trust grant 2019; Roche supplied glucose meters for the TOBOGM trial and provided access to the data.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db24-258-or","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:22:19Z","timestamp":1718349739000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["258-OR: The Effect of Early Initiation of Treatment on Glycemia and Pregnancy Outcomes in Women with Early Gestational Diabetes Mellitus"],"prefix":"10.2337","volume":"73","author":[{"given":"JINCY","family":"IMMANUEL","sequence":"first","affiliation":[{"name":"Denton, TX, North Adelaide, Australia, SYDNEY, Australia, Liverpool, Australia, Kingswood, Australia, Palmyra DC, Australia, Canberra, Australia, Melbourne, Australia, Chennai, India, Woden, Australia, Vienna, Austria, \u00d6rebro, Sweden, Campbelltown NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WILLIAM","family":"HAGUE","sequence":"additional","affiliation":[{"name":"Denton, TX, North Adelaide, Australia, SYDNEY, Australia, Liverpool, Australia, Kingswood, Australia, Palmyra DC, Australia, Canberra, Australia, Melbourne, Australia, Chennai, India, Woden, Australia, Vienna, Austria, \u00d6rebro, Sweden, Campbelltown NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ARIANNE","family":"SWEETING","sequence":"additional","affiliation":[{"name":"Denton, TX, North Adelaide, Australia, SYDNEY, Australia, Liverpool, Australia, Kingswood, Australia, Palmyra DC, Australia, Canberra, Australia, Melbourne, Australia, Chennai, India, Woden, Australia, Vienna, Austria, \u00d6rebro, Sweden, Campbelltown NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VINCENT W.M.","family":"WONG","sequence":"additional","affiliation":[{"name":"Denton, TX, North Adelaide, Australia, SYDNEY, Australia, Liverpool, Australia, Kingswood, Australia, Palmyra DC, Australia, Canberra, Australia, Melbourne, Australia, Chennai, India, Woden, Australia, Vienna, Austria, \u00d6rebro, Sweden, Campbelltown NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EMILY","family":"HIBBERT","sequence":"additional","affiliation":[{"name":"Denton, TX, North Adelaide, Australia, SYDNEY, Australia, Liverpool, Australia, Kingswood, Australia, Palmyra DC, Australia, Canberra, Australia, Melbourne, Australia, Chennai, India, Woden, Australia, Vienna, Austria, \u00d6rebro, Sweden, Campbelltown NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EMILY J.","family":"GIANATTI","sequence":"additional","affiliation":[{"name":"Denton, TX, North Adelaide, Australia, SYDNEY, Australia, Liverpool, Australia, Kingswood, Australia, Palmyra DC, Australia, Canberra, Australia, Melbourne, Australia, Chennai, India, Woden, Australia, Vienna, Austria, \u00d6rebro, Sweden, Campbelltown NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL J.","family":"PEEK","sequence":"additional","affiliation":[{"name":"Denton, TX, North Adelaide, Australia, SYDNEY, Australia, Liverpool, Australia, Kingswood, Australia, Palmyra DC, Australia, Canberra, Australia, Melbourne, Australia, Chennai, India, Woden, Australia, Vienna, Austria, \u00d6rebro, Sweden, Campbelltown NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HELENA","family":"TEEDE","sequence":"additional","affiliation":[{"name":"Denton, TX, North Adelaide, Australia, SYDNEY, Australia, Liverpool, Australia, Kingswood, Australia, Palmyra DC, Australia, Canberra, Australia, Melbourne, Australia, Chennai, India, Woden, Australia, Vienna, Austria, \u00d6rebro, Sweden, Campbelltown NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VISWANATHAN","family":"MOHAN","sequence":"additional","affiliation":[{"name":"Denton, TX, North Adelaide, Australia, SYDNEY, Australia, Liverpool, Australia, Kingswood, Australia, Palmyra DC, Australia, Canberra, Australia, Melbourne, Australia, Chennai, India, Woden, Australia, Vienna, Austria, \u00d6rebro, Sweden, Campbelltown NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"WAH CHEUNG","sequence":"additional","affiliation":[{"name":"Denton, TX, North Adelaide, Australia, SYDNEY, Australia, Liverpool, Australia, Kingswood, Australia, Palmyra DC, Australia, Canberra, Australia, Melbourne, Australia, Chennai, India, Woden, Australia, Vienna, Austria, \u00d6rebro, Sweden, Campbelltown NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTOPHER J.","family":"NOLAN","sequence":"additional","affiliation":[{"name":"Denton, TX, North Adelaide, Australia, SYDNEY, Australia, Liverpool, Australia, Kingswood, Australia, Palmyra DC, Australia, Canberra, Australia, Melbourne, Australia, Chennai, India, Woden, Australia, Vienna, Austria, \u00d6rebro, Sweden, Campbelltown NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALEXANDRA","family":"KAUTZKY-WILLER","sequence":"additional","affiliation":[{"name":"Denton, TX, North Adelaide, Australia, SYDNEY, Australia, Liverpool, Australia, Kingswood, Australia, Palmyra DC, Australia, Canberra, Australia, Melbourne, Australia, Chennai, India, Woden, Australia, Vienna, Austria, \u00d6rebro, Sweden, Campbelltown NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00dcRGEN","family":"HARREITER","sequence":"additional","affiliation":[{"name":"Denton, TX, North Adelaide, Australia, SYDNEY, Australia, Liverpool, Australia, Kingswood, Australia, Palmyra DC, Australia, Canberra, Australia, Melbourne, Australia, Chennai, India, Woden, Australia, Vienna, Austria, \u00d6rebro, Sweden, Campbelltown NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HELENA E.","family":"BACKMAN","sequence":"additional","affiliation":[{"name":"Denton, TX, North Adelaide, Australia, SYDNEY, Australia, Liverpool, Australia, Kingswood, Australia, Palmyra DC, Australia, Canberra, Australia, Melbourne, Australia, Chennai, India, Woden, Australia, Vienna, Austria, \u00d6rebro, Sweden, Campbelltown NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"SIMMONS","sequence":"additional","affiliation":[{"name":"Denton, TX, North Adelaide, Australia, SYDNEY, Australia, Liverpool, Australia, Kingswood, Australia, Palmyra DC, Australia, Canberra, Australia, Melbourne, Australia, Chennai, India, Woden, Australia, Vienna, Austria, \u00d6rebro, Sweden, Campbelltown NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/258-OR\/156581\/258-OR-The-Effect-of-Early-Initiation-of-Treatment","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/258-OR\/156581\/258-OR-The-Effect-of-Early-Initiation-of-Treatment","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:22:19Z","timestamp":1718349739000},"score":7.7453165,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/258-OR\/156581\/258-OR-The-Effect-of-Early-Initiation-of-Treatment"}},"issued":{"date-parts":[[2024,6,14]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2024,6,14]]}},"URL":"https:\/\/doi.org\/10.2337\/db24-258-or","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2024,6,14]]},"article-number":"258-OR"},{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:46:38Z","timestamp":1756896398696},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"4_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2016,2,15]]},"abstract":"Abstract<\/jats:title>\n Background: Analyses across multiple Australian states have consistently demonstrated significantly inferior breast cancer survival for Indigenous patients (IPs). Studies compensating for increased remoteness, socioeconomic disadvantage and later presentation demonstrate a residual unexplained detriment. This survival disadvantage is confined to the first five years, akin to the inferior outcomes demonstrated by higher risk biological breast cancer subtypes. We postulated that a preponderance of such higher risk subtypes could explain the disparate mortalities.<\/jats:p>\n Methods: The distribution of breast cancer subtypes in Western Australian IPs diagnosed between 2001 and 2010 was assessed to explore the contribution of adverse prognostic subtypes to poorer outcome. This was a retrospective cohort study of Indigenous women (n=114) and 3:1 age and remoteness matched non-Indigenous women (n=310) diagnosed with invasive, non-metastatic, unilateral breast cancer, who underwent definitive local treatment. Subtypes were assigned as luminal A, B, HER2 enriched and triple negative by ER, PR, HER2 and tumour grade comparisons. Differences in basic tumour demographics and biological sub-types were analysed and racial survival discrepancies explored within biological subtype cohorts.<\/jats:p>\n Results: Hazards for overall and breast cancer-specific mortality in IPs were 4.07 (95% CI 2.55-6.49) and 4.19 (95% CI 2.42-7.25). IPs were significantly more likely to have grade 3 tumours (41 v 25%, p&lt;0.001), LN positive disease (39 v 27%, p&lt;0.001) and larger tumours (median 20 v 10 mm, p&lt;0.001). No significant differences in proportions of classical histological sub-types (ductal v lobular) or in tumours showing ER, PR or HER2 positivity were observed. There were no significant differences in biological sub-type proportions although IPs were diagnosed with numerically more non-Luminal A subtypes (56 v 44%, p=0.08), accounted for by increased Luminal B (21 v 15%) and HER2 enriched (10 v 5%) sub-types. The significant relative five-year survival deficit for IPs noted overall (94 v73%, p&lt;0.0001) was observed for each sub-type with the exception of HER2 positive patients. This extended from the relatively low risk luminal A sub-type where oral anti-estrogens are the mainstay of treatment (98 v 82%, p=0.0002) to the high risk triple negative sub-type where intravenous chemotherapy is the standard adjuvant therapy (94 v 50%, p=0.0014).<\/jats:p>\n Conclusions: The contribution of adverse tumour biological subtype to poorer outcomes for Indigenous women is modest. Indigenous women with almost all biological subtypes fare significantly worse than their non-Indigenous contemporaries. Ongoing work includes more detailed biological comparisons of RNA expression and DNA mutation between groups as well as an exploration of potentially disparate treatment patterns.<\/jats:p>\n Citation Format: Redfern A, Lee E, Bulsara M, Threlfall T, Harvey J, Cordell D. Does adverse tumour biology contribute to inferior outcomes for Indigenous Australians diagnosed with breast cancer?. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P1-09-08.<\/jats:p>","DOI":"10.1158\/1538-7445.sabcs15-p1-09-08","type":"journal-article","created":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T08:47:55Z","timestamp":1463734075000},"page":"P1-09-08-P1-09-08","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Abstract P1-09-08: Does adverse tumour biology contribute to inferior outcomes for Indigenous Australians diagnosed with breast cancer?"],"prefix":"10.1158","volume":"76","author":[{"given":"A","family":"Redfern","sequence":"first","affiliation":[{"name":"University ofWestern Australia, Perth, Western Australia, Australia; Royal Perth Hospital, Perth, Western Australia, Australia; University of Notre Dame, Perth, Western Australia, Australia; Department of Health, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Lee","sequence":"additional","affiliation":[{"name":"University ofWestern Australia, Perth, Western Australia, Australia; Royal Perth Hospital, Perth, Western Australia, Australia; University of Notre Dame, Perth, Western Australia, Australia; Department of Health, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bulsara","sequence":"additional","affiliation":[{"name":"University ofWestern Australia, Perth, Western Australia, Australia; Royal Perth Hospital, Perth, Western Australia, Australia; University of Notre Dame, Perth, Western Australia, Australia; Department of Health, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Threlfall","sequence":"additional","affiliation":[{"name":"University ofWestern Australia, Perth, Western Australia, Australia; Royal Perth Hospital, Perth, Western Australia, Australia; University of Notre Dame, Perth, Western Australia, Australia; Department of Health, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Harvey","sequence":"additional","affiliation":[{"name":"University ofWestern Australia, Perth, Western Australia, Australia; Royal Perth Hospital, Perth, Western Australia, Australia; University of Notre Dame, Perth, Western Australia, Australia; Department of Health, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Cordell","sequence":"additional","affiliation":[{"name":"University ofWestern Australia, Perth, Western Australia, Australia; Royal Perth Hospital, Perth, Western Australia, Australia; University of Notre Dame, Perth, Western Australia, Australia; Department of Health, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/76\/4_Supplement\/P1-09-08\/614504\/Abstract-P1-09-08-Does-adverse-tumour-biology","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/76\/4_Supplement\/P1-09-08\/614504\/Abstract-P1-09-08-Does-adverse-tumour-biology","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T18:38:04Z","timestamp":1656095884000},"score":7.7426057,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/76\/4_Supplement\/P1-09-08\/614504\/Abstract-P1-09-08-Does-adverse-tumour-biology"}},"issued":{"date-parts":[[2016,2,15]]},"references-count":0,"journal-issue":{"issue":"4_Supplement","published-print":{"date-parts":[[2016,2,15]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.sabcs15-p1-09-08","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2016,2,15]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:13Z","timestamp":1753889833386,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2021,6,1]]},"abstract":"In prediabetes (PD), circulating inflammatory biomarkers are associated with increased CVD1 risk. Exercise (Ex) has a positive effect on cardiovascular fitness and metabolic outcomes in PD but Ex effects on inflammation markers in PD are not fully known and were investigated in this study. Adults with PD (n=34) and normal fasting glucose (NG) (n=34) were randomised into one of four groups: NG control (NGC, n=16), NG Ex (NGE, n=18), PD control (PC, n=16) and PD Ex (PE, n=18). NGE\/PE completed 12 weeks of supervised HIIT and progressive resistance training (PRT) 2 times\/week, and NGC\/PC unsupervised stretching 3 times\/week. Baseline, age and weight were similar in PD and NG. Compared with NG, FPG and HbA1c were higher and VO2peak was significantly lower in PD (29\u00b17 vs. 33\u00b18 mL\/kg\/min, p=0.03). Comparing NG and PD at baseline, serum IL-1\u03b2 was higher in NG (11.4\u00b19.0 vs. 7.9\u00b12.8 pg\/mL, p=0.04), IL-12p70 and IL-22 were higher in PD (respectively, 5.7\u00b13.6 vs. 4.4\u00b12.2 pg\/mL; 164.6\u00b190.3 vs. 122.2\u00b183.2 pg\/mL, both p&lt;0.05) and IL-1\u03b1, IL-6, IL-8, IL-15, M-CSF and TNF\u03b1 were similar. At follow-up, HbA1c was reduced by -0.07\u00b10.11% in NGE and -0.09\u00b10.17% in PC (both p&lt;0.05) and not changed in PE or NGC. PE had an increase in VO2peak (5.5\u00b17.5mL\/kg\/min, p=0.01). Inflammatory biomarkers were unchanged in PE but NGE had reduced IL-12p70 (4.3\u00b11.9 to 3.5\u00b10.8 pg\/mL, p=0.05) and M-CSF (124.5\u00b158.2 to 93.8\u00b136.2 pg\/mL, p=0.02). Analysis of Ex with &gt;80% adherence revealed that IL-1\u03b1, IL-1\u03b2, IL-8 and IL-15 were reduced in NGE, however no change was seen in PE despite a reduction in HbA1c of -0.14\u00b10.17% (p=0.02). PD is associated with reduced cardiorespiratory fitness and increased IL-12p70 and IL-22. Ex reduced IL-12p70 and M-CSF in those with NG but not PD, even after stratifying by adherence and despite improvements in clinical markers. This study indicates low volume HIIT with PRT may not be adequate to reduce serum inflammatory biomarkers in prediabetes.<\/jats:p>\n \n Disclosure<\/jats:title>\n C. J. Baker: None. D. Min: None. J. Gerofi: None. X. Wang: None. S. L. Hocking: Advisory Panel; Self; Eli Lilly and Company, Inova, Novo Nordisk, Pfizer Inc. S. Colagiuri: None. N. A. Johnson: None. S. M. Twigg: Advisory Panel; Self; Abbott Diabetes, AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Sanofi-Aventis, Consultant; Self; Aktivo Labs, Sanofi-Aventis, Research Support; Self; Abbott Diabetes, Speaker\u2019s Bureau; Self; Abbott Diabetes, AstraZeneca.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Health and Medical Research Council (APP1113612)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db21-233-or","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T22:14:53Z","timestamp":1624572893000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["233-OR: Circulating Inflammatory Biomarkers Are Not Improved with Combined Low-Volume High-Intensity Interval Training and Progressive Resistance Training in Prediabetes"],"prefix":"10.2337","volume":"70","author":[{"given":"CALLUM J.","family":"BAKER","sequence":"first","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia, Dulwich Hill, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DANQING","family":"MIN","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia, Dulwich Hill, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAMES","family":"GEROFI","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia, Dulwich Hill, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIAOYU","family":"WANG","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia, Dulwich Hill, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SAMANTHA L.","family":"HOCKING","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia, Dulwich Hill, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN","family":"COLAGIURI","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia, Dulwich Hill, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NATHAN A.","family":"JOHNSON","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia, Dulwich Hill, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN M.","family":"TWIGG","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia, Dulwich Hill, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/233-OR\/139862\/233-OR-Circulating-Inflammatory-Biomarkers-Are-Not","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/233-OR\/139862\/233-OR-Circulating-Inflammatory-Biomarkers-Are-Not","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T11:36:53Z","timestamp":1647171413000},"score":7.741094,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/233-OR\/139862\/233-OR-Circulating-Inflammatory-Biomarkers-Are-Not"}},"issued":{"date-parts":[[2021,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db21-233-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2021,6,1]]},"article-number":"233-OR"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:13Z","timestamp":1753889773554,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: Gestational diabetes mellitus (GDM) risk varies by area and is potentially associated with social disparity and variation in the built environment. There remains limited evidence examining the association between socio-ecological factors and GDM risk. This study examined the association between socio-ecological factors and GDM risk at local area level over time in Australia.<\/jats:p>\n Methods: An ecological study was undertaken using multisource national data at Statistical Area Level 2 (SA2: medium-sized geographical unit) in Australia from 2016-22. SA2-level GDM cases and births were obtained from national registries. Social and built environment covariates were aggregated to the SA2 level. Spatiotemporal ecological regression was undertaken using a Bayesian approach, and an adjusted risk ratio with 95% credible intervals (CrIs) was estimated.<\/jats:p>\n Results: Across 1,486 SA2s, 207,163 GDM cases occurred from 1,719,396 births. In areas with a high concentration of at-risk migrant women (location quotient \u2265 1), GDM was 1.10 (95% CrI; 1.07, 1.13) compared to low concentration. GDM risk was associated with a lower level of socioeconomic position, with least (vs most) advantaged areas having an 18% greater risk of GDM (1.18[95% CrI; 1.10, 1.26]). Compared to areas with the least access to fast food outlets (4th quartile), other quartiles were associated with increased GDM risk, with the greatest in the 1st (highest access) (1.12 [95% CrI; 1.04,1.20]). Residing in the least-moderate walkable areas (2nd quartile) was associated with higher GDM risk (1.08[95% CrI; 1.02, 1.14]) than most walkable areas.<\/jats:p>\n Conclusion: Area-level GDM risk was associated with socioeconomic disadvantage, high concentrations of at-risk migrant women, least-moderate walkability, and highest fast-food access. Tailored population-level interventions targeting socioeconomic, ethnic, and built environment attributes may improve preventive health efforts.<\/jats:p>\n \n Disclosure<\/jats:title>\n W.W. Takele: None. R. Beare: None. L.L. Dalli: None. S. Lim: None. J. Boyle: Other Relationship; Elsevier.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-1245-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:07:10Z","timestamp":1749791230000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1245-P: Where You Live Matters\u2014Association between Socioecological Factors and Gestational Diabetes Mellitus Risk in Australia"],"prefix":"10.2337","volume":"74","author":[{"given":"WUBET W.","family":"TAKELE","sequence":"first","affiliation":[{"name":"Clayton, Australia, Frankston, Australia, Boxhill, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"BEARE","sequence":"additional","affiliation":[{"name":"Clayton, Australia, Frankston, Australia, Boxhill, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LACHLAN L.","family":"DALLI","sequence":"additional","affiliation":[{"name":"Clayton, Australia, Frankston, Australia, Boxhill, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SIEW","family":"LIM","sequence":"additional","affiliation":[{"name":"Clayton, Australia, Frankston, Australia, Boxhill, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JACQUELINE","family":"BOYLE","sequence":"additional","affiliation":[{"name":"Clayton, Australia, Frankston, Australia, Boxhill, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1245-P\/158411\/1245-P-Where-You-Live-Matters-Association-between","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1245-P\/158411\/1245-P-Where-You-Live-Matters-Association-between","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T15:36:17Z","timestamp":1750433777000},"score":7.7406554,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1245-P\/158411\/1245-P-Where-You-Live-Matters-Association-between"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-1245-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"1245-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:35:54Z","timestamp":1753889754966,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Clinical practice guidelines recommend screening for diabetes after the age of 45 years, but without an upper age limit. An ageing population has resulted in increasing numbers of older people being diagnosed. Previous reports indicate a J-shaped relationship between HbA1c and mortality in older populations with largely longstanding diabetes. However, whether these mortality relationships hold true in the newly diagnosed elderly remains uncertain, as do appropriate glycaemic targets. We aimed to study the relationship between HbA1c and mortality in newly diagnosed elderly aged \u2265 75 years. Records from the RPA Diabetes Clinical Database from 1988 to 2015, linked with the Australian National Death Index to establish all cause, IHD and cancer mortality outcomes were examined. 376 subjects were studied; median diabetes duration at first visit was 0.8 years (IQR 0.2-2.4), with mean age at diagnosis 78.7\u00b13.1 years, 48% male and 53% Angloceltic. Data were stratified by updated HbA1c% NGSP Units categories (&lt; 6; 6.1-7.0; 7.1-8.0; 8.1-9.0 and &gt;9) with a median of 1.8\u00b11.5 measures. Over a median observation period of 6.0 (IQR 2.8-10.4) years there were 237 deaths (17% from cancer, 38.9% from IHD). Using Kaplan-Meier survival analysis for all-cause mortality, no differences in survival between the HbA1c categories were seen (logrank p=0.8). Cox regression was used to examine the relationship between all-cause mortality and updated HbA1c categories after accounting for age or duration at first visit, gender and ethnicity. No significant differences nor observable trends in RR were seen using the HbA1c 6.1-7% group as reference. Prior albuminuria, stroke history and lipid status also had no impact on this relationship. Examination of IHD and cancer-related deaths similarly showed no relationship with HbA1c in this population. Whilst current guidelines recommend a general HbA1c target of 7% to 8% in the elderly we did not demonstrate a survival benefit for any HbA1c level in these newly diagnosed over 75 years of age.<\/jats:p>\n \n Disclosure<\/jats:title>\n M. McGill: None. L.M. Molyneaux: None. M.I. Constantino: None. S.M. Twigg: Advisory Panel; Self; Abbott, Boehringer Ingelheim Pharmaceuticals, Inc., Novo Nordisk Inc., Sanofi-Aventis. Board Member; Self; AstraZeneca. Research Support; Self; Abbott. Speaker's Bureau; Self; Abbott, AstraZeneca, Merck Sharp & Dohme Corp., Novo Nordisk Inc., Sanofi-Aventis. T. Middleton: Other Relationship; Self; AstraZeneca. T. Wu: Advisory Panel; Self; Boehringer Ingelheim International GmbH, Eli Lilly and Company, Novo Nordisk A\/S, Sanofi. Speaker's Bureau; Self; AstraZeneca, Boehringer Ingelheim International GmbH, Eli Lilly and Company, Merck Sharp & Dohme Corp., Novo Nordisk A\/S, Sanofi. J. Wong: Advisory Panel; Self; Sanofi. Speaker's Bureau; Self; AstraZeneca, Lilly Diabetes.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-1440-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T01:10:57Z","timestamp":1559697057000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1440-P: Does HbA1c Impact Survival in the Newly Diagnosed Elderly Aged 75 Years and Over?"],"prefix":"10.2337","volume":"68","author":[{"given":"MARGARET","family":"MCGILL","sequence":"first","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"SR.","given":"LYNDA M.","family":"MOLYNEAUX","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA I.","family":"CONSTANTINO","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN M.","family":"TWIGG","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIMOTHY","family":"MIDDLETON","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TED","family":"WU","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENCIA","family":"WONG","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1440-P\/61320\/1440-P-Does-HbA1c-Impact-Survival-in-the-Newly","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1440-P\/61320\/1440-P-Does-HbA1c-Impact-Survival-in-the-Newly","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:52:16Z","timestamp":1647168736000},"score":7.739846,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1440-P\/61320\/1440-P-Does-HbA1c-Impact-Survival-in-the-Newly"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-1440-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"1440-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:46Z","timestamp":1753889866277,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"Background: We evaluated the feasibility and safety of endoscopic re-cellularization via electroporation therapy (ReCET) (Endogenex. Plymouth, MN) in restoring impaired duodenal signaling adversely impacting glucose control in type 2 diabetes (T2D).<\/jats:p>\n Method: We enrolled 30 adults with T2D: duration \u226410 years; HbA1c 7.5-11.0%; BMI of 24-40 kg\/m2; C-peptide \u2265333pmol\/L; 1-4 non-insulin glucose-lowering medications (GLMs) at stable dose. Post-procedure GLMs were unchanged. Primary endpoint: Device or procedure-related serious adverse events (SAEs). Secondary endpoints: Changes in metabolic parameters at 24W.<\/jats:p>\n Results: The first 12 participants received single energy (Single Tx) then 18 received double energy application (Double Tx) with no device\/procedure-related SAEs. Forty-five adverse events were reported in 23\/30 participants (sore throat [17\/30]; transient diarrhea [9\/30]) and 80% were mild.<\/jats:p>\n HbA1c reduction at 24W was greater with double vs. single Tx (p&lt;0.05). For double Tx vs. baseline: FPG was 7.5\u00b11.7 mmol\/L vs. 9.8\u00b12.2 mmol\/L (p&lt;0.01), HOMA-IR 4.5\u00b13.6 vs. 7.4\u00b13.3 (p&lt;0.01), Time-in-range 79.4\u00b118.8 % vs. 59.0\u00b124.2% (p&lt;0.01), triglyceride 2.0\u00b11.2mmol\/L vs. 2.9\u00b11.9mmol\/L (P&lt;0.05) and \u0394weight -5.1%\u00b14.1% (p&lt;0.01).<\/jats:p>\n Conclusions: Our data suggest that ReCET is safe and associated with clinically meaningful changes in metabolic control in T2D patients on GLMs.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n C.Yuan: None. A.Sartoretto: Advisory Panel; Bariatek, Research Support; Endogenex, Erbe Electromedizin GMBH, Speaker's Bureau; Pfizer Inc., Stock\/Shareholder; Apollo Endosurgery. B.Holt: None. G.Cameron: None. G.Marinos: None. F.E.Napier-flood: None. B.K.Abu dayyeh: Advisory Panel; Endogenex, Consultant; Apollo Endosurgery, Boston Scientific Corporation, Medtronic, Research Support; USGI, Endogastric Solutions. D.N.O'neal: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-835-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:30:16Z","timestamp":1687239016000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":3,"title":["835-P: First-in-Human Duodenal Endoscopic Recellularization via Electroporation Therapy for Type 2 Diabetes\u2014An Interim Report"],"prefix":"10.2337","volume":"72","author":[{"given":"CHENG","family":"YI YUAN","sequence":"first","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Randwick, Australia, Gladesville, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ADRIAN","family":"SARTORETTO","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Randwick, Australia, Gladesville, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRONTE","family":"HOLT","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Randwick, Australia, Gladesville, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GEORGINA","family":"CAMERON","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Randwick, Australia, Gladesville, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GEORGE","family":"MARINOS","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Randwick, Australia, Gladesville, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FIONA E.","family":"NAPIER-FLOOD","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Randwick, Australia, Gladesville, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BARHAM K.","family":"ABU DAYYEH","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Randwick, Australia, Gladesville, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Randwick, Australia, Gladesville, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/835-P\/149654\/835-P-First-in-Human-Duodenal-Endoscopic","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/835-P\/149654\/835-P-First-in-Human-Duodenal-Endoscopic","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:30:16Z","timestamp":1687239016000},"score":7.738736,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/835-P\/149654\/835-P-First-in-Human-Duodenal-Endoscopic"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-835-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"835-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:18Z","timestamp":1753889838861,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Objective: We aimed to determine the prevalence of preexisting dysglycaemia in inpatients admitted with acute coronary syndrome (ACS), their characteristics and, association with acute and 12-month clinical outcomes.<\/jats:p>\n Research Design and Methods: In this prospective observational cohort study, admission HbA1c testing was undertaken on consecutive inpatients aged \u226554 years admitted with ACS. Patients were categorised into those with diabetes (prior diagnosis or HbA1c \u2265 6.5%, \u226548mmol\/mol), prediabetes (HbA1c 5.7-6.4%, 39-46mmol\/mol) and no diabetes (HbA1c &lt;5.6%, &lt;38mmol\/mol).<\/jats:p>\n Results: Between July 2013 and July 2015, 847 consecutive inpatients aged \u226554 years were admitted with ACS. 313 (37%) inpatients had diabetes, 312(37%) had prediabetes and 222(25%) had no diabetes. After adjusting for age, sex, smoking status and previous myocardial infarction, diabetes, as opposed to no diabetes, was associated with higher odds of Acute Pulmonary Oedema (APO) (OR 2.60, P&lt;0.01), longer length of stay (LOS) (IRR 1.18, P=0.02) and, higher odds of 12-month ACS recurrence (OR 1.86, P&lt;0.05). Prediabetes was not a statistically significant marker of adverse clinical outcomes. However, analysed as a continuous variable, every 1% (11 mmol\/mol) increase in HbA1c was associated with increased odds of APO (OR 1.28, P=0.002) and, longer LOS (IRR 1.05, P=0.03).<\/jats:p>\n Conclusions: In our study, three-quarters of all inpatients aged \u226554 years admitted with ACS had preexisting dysglycaemia. Inpatients with diabetes had increased odds of APO, longer LOS and higher 12-month ACS recurrence. Higher HbA1c, was associated with increased odds of APO and longer LOS. Randomised studies with cardioprotective anti-hyperglycaemic agents are necessary in determining if improving dysglycaemia in ACS patients improves clinical outcomes.<\/jats:p>\n \n Disclosure<\/jats:title>\n D. Mahendran: None. G. Hamilton: None. J. Weiss: None. J. Lew: None. K. Khoo: None. E.I. Ekinci: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-420-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:33Z","timestamp":1529693853000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Preexisting Dysglycaemia among Inpatients with Acute Coronary Syndrome and Associations with Outcomes"],"prefix":"10.2337","volume":"67","author":[{"given":"DINESH","family":"MAHENDRAN","sequence":"first","affiliation":[{"name":"Carnegie, Australia, Melbourne, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GARRY","family":"HAMILTON","sequence":"additional","affiliation":[{"name":"Carnegie, Australia, Melbourne, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEREMY","family":"WEISS","sequence":"additional","affiliation":[{"name":"Carnegie, Australia, Melbourne, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEREMY","family":"LEW","sequence":"additional","affiliation":[{"name":"Carnegie, Australia, Melbourne, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAYLYN","family":"KHOO","sequence":"additional","affiliation":[{"name":"Carnegie, Australia, Melbourne, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIF I.","family":"EKINCI","sequence":"additional","affiliation":[{"name":"Carnegie, Australia, Melbourne, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/420-P\/60201\/Prevalence-of-Preexisting-Dysglycaemia-among","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/420-P\/60201\/Prevalence-of-Preexisting-Dysglycaemia-among","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:24:47Z","timestamp":1647167087000},"score":7.7363567,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/420-P\/60201\/Prevalence-of-Preexisting-Dysglycaemia-among"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-420-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"420-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:35:48Z","timestamp":1753889748916,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Background: Despite being a common comorbidity, diabetes is often overlooked when patients present to the emergency department (ED) with nondiabetic emergencies.<\/jats:p>\n Aims: To examine the associations between insulin treated patients presenting to the ED with nondiabetic emergencies and;<\/jats:p>\n (i) adverse glycaemia (AG); including hypoglycaemia (&lt; 70 mg\/dL) and hyperglycaemia (&lt; 180 mg\/dL) and insulin prescribing errors,<\/jats:p>\n (ii) glycaemic variability and AG following ED evaluation and ward diabetes management.<\/jats:p>\n Methods: A two-year retrospective medical record audit of discharged insulin treated adult patients (\u2265 18 years) was conducted at a quaternary hospital. All patients presented to the ED with nondiabetic emergencies and admitted to general wards for &gt; 24 hours and &lt; 30 days.<\/jats:p>\n Results: Of the 103 patients (Table), 25 (24%) had one or more prescribing errors charted in the ED. Thirty-nine (37.8%) patients experienced hypoglycaemia. Of these, 21 (53.8%) were prescribed sliding scale insulin (SSI) in the ED (p = 0.05). Despite uncontrolled hyperglycaemia, 40 (47.6%) patients had no change to their diabetes treatment during admission (p = 0.04).<\/jats:p>\n Conclusions: Half of insulin treated patients experienced uncontrolled hyperglycaemia. Use of SSI regimens prescribed in the ED were associated with higher risk of AG. Safety for insulin treated patients should be prioritised from the time the hospital journey begins in ED to after discharge.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n S.L. Patterson: None. E.I. Ekinci: None. A. Driscoll: None. B. Rasmussen: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-1203-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:46Z","timestamp":1592238586000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1203-P: Safety Implications of Insulin Prescribing in the Emergency Department"],"prefix":"10.2337","volume":"69","author":[{"given":"SIMONE L.","family":"PATTERSON","sequence":"first","affiliation":[{"name":"Heidelberg, Australia, Melbourne, Australia, Geelong, Australia, Burwood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIF I.","family":"EKINCI","sequence":"additional","affiliation":[{"name":"Heidelberg, Australia, Melbourne, Australia, Geelong, Australia, Burwood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREA","family":"DRISCOLL","sequence":"additional","affiliation":[{"name":"Heidelberg, Australia, Melbourne, Australia, Geelong, Australia, Burwood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BODIL","family":"RASMUSSEN","sequence":"additional","affiliation":[{"name":"Heidelberg, Australia, Melbourne, Australia, Geelong, Australia, Burwood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1203-P\/60925\/1203-P-Safety-Implications-of-Insulin-Prescribing","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1203-P\/60925\/1203-P-Safety-Implications-of-Insulin-Prescribing","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:20:05Z","timestamp":1647166805000},"score":7.736135,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1203-P\/60925\/1203-P-Safety-Implications-of-Insulin-Prescribing"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-1203-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"1203-P"},{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:50:21Z","timestamp":1761490221077},"reference-count":0,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"16_suppl","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1200\/jco.2005.23.16_suppl.6067","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T18:55:09Z","timestamp":1487876109000},"page":"6067-6067","source":"Crossref","is-referenced-by-count":4,"title":["Satisfaction with the decision to participate in cancer clinical trials (CCT) is high, but understanding is a problem"],"prefix":"10.1200","volume":"23","author":[{"given":"M.","family":"Jefford","sequence":"first","affiliation":[{"name":"Cancer Trials Australia, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Mileshkin","sequence":"additional","affiliation":[{"name":"Cancer Trials Australia, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Raunow","sequence":"additional","affiliation":[{"name":"Cancer Trials Australia, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"O\u2019Kane","sequence":"additional","affiliation":[{"name":"Cancer Trials Australia, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Cavicchiolo","sequence":"additional","affiliation":[{"name":"Cancer Trials Australia, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Brasier","sequence":"additional","affiliation":[{"name":"Cancer Trials Australia, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Cancer Trials Australia, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Cancer Trials Australia, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Cancer Trials Australia, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","container-title":["Journal of Clinical Oncology"],"language":"en","link":[{"URL":"http:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/jco.2005.23.16_suppl.6067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T21:19:34Z","timestamp":1574889574000},"score":7.7352037,"resource":{"primary":{"URL":"http:\/\/ascopubs.org\/doi\/10.1200\/jco.2005.23.16_suppl.6067"}},"issued":{"date-parts":[[2005,6]]},"references-count":0,"journal-issue":{"issue":"16_suppl","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1200\/jco.2005.23.16_suppl.6067"],"URL":"https:\/\/doi.org\/10.1200\/jco.2005.23.16_suppl.6067","ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"published":{"date-parts":[[2005,6]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:07Z","timestamp":1753889827914,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Background: Management of diabetes and chronic disease is a challenge, making mHealth an increasingly attractive option. There is evidence that these apps may be effective, with systematic reviews demonstrating improvements in HbA1c and other measures of diabetes control. However, dropout can be a major issue in apps. Recent research has indicated that rates of attrition in mHealth interventions may be as high as 98%. Knowledge of mHealth dropout rates is critical to assessing their efficacy.<\/jats:p>\n Methods: Medline, Pubmed, Cochrane CENTRAL, and Embase were searched from 2003 to the present, looking at mHealth and attrition or dropout. Studies looking at chronic disease with measures of dropout were included.<\/jats:p>\n Results: Of 830 studies identified in the literature search, 16 were included in the review and meta-analysis (results presented below). Chronic disease management apps had an overall dropout rate of 47%. Apps targeting metabolic disease had a lower rate of 32%. The studies were varied, with high heterogeneity (I2&gt;99%).<\/jats:p>\n Conclusion: Dropout rates in mHealth interventions are high, but lower in apps targeting metabolic disease. Reducing dropout rates will make these apps more effective for disease management in the long term.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n G. Meyerowitz-Katz: None. T. Astell-Burt: None. S. Ravi: None. L.F. Arnolda: None. X. Feng: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-775-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:38:49Z","timestamp":1592239129000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["775-P: Mobile Self-Management Apps to Manage Diabetes and Chronic Disease: A Systematic Review and Meta-analysis into Dropout and Attrition Rates"],"prefix":"10.2337","volume":"69","author":[{"given":"GIDEON","family":"MEYEROWITZ-KATZ","sequence":"first","affiliation":[{"name":"Blacktown, Australia, Wollongong, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"THOMAS","family":"ASTELL-BURT","sequence":"additional","affiliation":[{"name":"Blacktown, Australia, Wollongong, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUMATHY","family":"RAVI","sequence":"additional","affiliation":[{"name":"Blacktown, Australia, Wollongong, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEONARD F.","family":"ARNOLDA","sequence":"additional","affiliation":[{"name":"Blacktown, Australia, Wollongong, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIAOQI","family":"FENG","sequence":"additional","affiliation":[{"name":"Blacktown, Australia, Wollongong, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/775-P\/59049\/775-P-Mobile-Self-Management-Apps-to-Manage","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/775-P\/59049\/775-P-Mobile-Self-Management-Apps-to-Manage","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:57:06Z","timestamp":1647165426000},"score":7.734432,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/775-P\/59049\/775-P-Mobile-Self-Management-Apps-to-Manage"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-775-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"775-P"},{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:05:04Z","timestamp":1780700704438,"version":"3.54.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2026,6,5]]},"abstract":"Introduction and Objective: Type 1 diabetes (T1D) is characterized by pancreatic \u03b2-cell loss, impaired insulin secretion and hyperglycaemia. Insulin replacement normalises blood glucose, but may cause potentially lethal hypoglycaemia. Islet transplantation and stem cell therapy are limited by donor scarcity, and require life-long immunosuppression. This highlights the importance of preserving existing \u03b2-cells and\/or regenerating new \u03b2-cells in T1D. C-II-a is a mimetic peptide that regenerates insulin-containing, glucose-responsive cells and reduces hyperglycaemia in C57BL\/6J mice with diabetes. The study identifies C-II-a target genes in these mice and evaluates their relevance to T1D.<\/jats:p>\n Methods: C57BL\/6J mice were rendered diabetic with streptozotocin, then treated with C-II-a or PBS twice weekly for four weeks. Differentially expressed pancreatic genes were identified and localized by spatial transcriptomics. Changes in expression of key genes were validated by incubating INS-1E and AR42J cells with C-II-a, followed by RT-PCR and Western blotting. The functional impact of these changes were evaluated by glucose-stimulated insulin secretion.<\/jats:p>\n Results: Fasting blood glucose was 8.8\u00b11.5 mM in C-II-a-treated mice, and 11.9\u00b11.4 mM in control mice (p &lt;0.05). C-II-a treatment down regulated pancreatic Reg3 \u03b1, Reg3 \u03b2 , Reg3 \u03b3 and Mt1, and up regulated PRSS1 (p&lt;0.0001 for all). Incubation of INS-1E and AR42J cells with C-II-a decreased Reg3\u03b1, Reg3\u03b3, and Mt1 mRNA and protein levels (p&lt;0.05 for all) and increased PRSS1 expression (p&lt;0.05). Mt1 knockdown in INS-1E cells increased GSIS (p&lt;0.01).<\/jats:p>\n Conclusion: This study identifies C-II-a target genes associated with reduced fasting blood glucose in C57BL\/6J mice with diabetes and potential therapeutic approaches for improving glycaemic control in T1D.<\/jats:p>\n \n Disclosure<\/jats:title>\n I. Haleem: None. T. King: None. K. Chemello: None. B. Cochran: None. S. Thomas: None. K. Rye: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Health and Medical Research Council of Australia (APPP2004064)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db26-1819-p","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:41:44Z","timestamp":1780699304000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1819-P: Development of a Peptide That Improves Glycaemic Control in Type 1 Diabetes and Identification of Its Target Genes"],"prefix":"10.2337","volume":"75","author":[{"given":"IQRA","family":"HALEEM","sequence":"first","affiliation":[{"name":"Sydney, Australia, UNSW Sydney, Australia, Randwick, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THOMAS","family":"KING","sequence":"additional","affiliation":[{"name":"Sydney, Australia, UNSW Sydney, Australia, Randwick, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KEVIN","family":"CHEMELLO","sequence":"additional","affiliation":[{"name":"Sydney, Australia, UNSW Sydney, Australia, Randwick, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BLAKE","family":"COCHRAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, UNSW Sydney, Australia, Randwick, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHANE","family":"THOMAS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, UNSW Sydney, Australia, Randwick, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KERRY-ANNE","family":"RYE","sequence":"additional","affiliation":[{"name":"Sydney, Australia, UNSW Sydney, Australia, Randwick, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/1819-P\/168053\/1819-P-Development-of-a-Peptide-That-Improves","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/1819-P\/168053\/1819-P-Development-of-a-Peptide-That-Improves","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:41:44Z","timestamp":1780699304000},"score":7.7341704,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/1819-P\/168053\/1819-P-Development-of-a-Peptide-That-Improves"}},"issued":{"date-parts":[[2026,6,5]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2026,6,5]]}},"URL":"https:\/\/doi.org\/10.2337\/db26-1819-p","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2026,6,5]]},"article-number":"1819-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:25Z","timestamp":1753889845208,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2021,6,1]]},"DOI":"10.2337\/db21-625-p","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T22:15:03Z","timestamp":1624572903000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":5,"title":["625-P: Validation of Formulae to Estimate Insulin Sensitivity in Type 1 Diabetes"],"prefix":"10.2337","volume":"70","author":[{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"first","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAWEL","family":"NIEDZWIECKI","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NIRUPA","family":"SACHITHANANDAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GLENN M.","family":"WARD","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CONNIE","family":"KARSCHIMKUS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O\u2019NEAL","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DOROTA","family":"ZOZULINSKA-ZIOLKIEWICZ","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALEKSANDRA","family":"URUSKA","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/625-P\/140169\/625-P-Validation-of-Formulae-to-Estimate-Insulin","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/625-P\/140169\/625-P-Validation-of-Formulae-to-Estimate-Insulin","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T11:45:55Z","timestamp":1647171955000},"score":7.7337885,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/625-P\/140169\/625-P-Validation-of-Formulae-to-Estimate-Insulin"}},"issued":{"date-parts":[[2021,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db21-625-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2021,6,1]]},"article-number":"625-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:26Z","timestamp":1753889846728,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"The link between metabolic disorders during pregnancy and high risk of developing chronic noncommunicable diseases in later life has been well established. However, why the fetuses exposed to GDM have a higher risk of abnormal glucose homeostasis in later life, is still not fully understood. Exosomes have been well characterised in maternal circulation in normal and gestational diabetes pregnancies, however, the little is known about the profile of exosomes in fetal circulation. In this study, we isolated exosomes from cord-blood from women with normal tolerance glucose (NGT, n=35) and GDM (n=40) at the time of delivery. The miRNA content of exosomes was determined using a small RNA sequencing. The levels of circulating exosomes were significantly higher in GDM compared to NGT (p&lt;0.05). Linear regression analysis identified a positive association between fetal length, maternal BMI and the levels of circulating exosomes in GDM, while no significant association was observed for NGT. Analysis of the miRNA within exosomes identified a range of miRNAs differentially expressed between NGT and GDM samples. Principal component analysis reveals a separation of the groups based on their miRNA profile. The miRNA contributing the most to this separation between normal and GDM conditions is miR-22-3p, thus this miRNA may be a key candidate for future GDM diagnostic strategies. Gene Ontology analysis shows that the miRNAs identified in exosomes regulate genes involved in insulin secretion in response to glucose stimulus, insulin receptor signalling, and glucose homeostasis. Thus, these data suggest that exosomes may alter gene expression and ultimately the cell phenotype by transferring specific miRNAs to target cells.<\/jats:p>\n \n Disclosure<\/jats:title>\n V. Ormazabal: None. S. Nair: None. D. Guanzon: None. F. Zuniga: None. D. McIntyre: Other Relationship; Self; Novo Nordisk A\/S. M. Lappas: None. C. Salomon: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Diabetes Australia; Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico (1170809, 1190522)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-1375-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:48Z","timestamp":1592238588000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1375-P: Gestational Diabetes\u2013Associated Changes in the Circulating Exosomes in Fetal Circulation Revealed a Potential Role of These Nanovesicles in Fetal Growth and Metabolism"],"prefix":"10.2337","volume":"69","author":[{"given":"VALESKA","family":"ORMAZABAL","sequence":"first","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATHERIN","family":"SCHOLZ-ROMERO","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SOUMYALEKSHMI","family":"NAIR","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DOMINIC","family":"GUANZON","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FELIPE","family":"ZUNIGA","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"MCINTYRE","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTHA","family":"LAPPAS","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARLOS","family":"SALOMON","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1375-P\/61163\/1375-P-Gestational-Diabetes-Associated-Changes-in","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1375-P\/61163\/1375-P-Gestational-Diabetes-Associated-Changes-in","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:22:17Z","timestamp":1647166937000},"score":7.733674,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1375-P\/61163\/1375-P-Gestational-Diabetes-Associated-Changes-in"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-1375-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"1375-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:53Z","timestamp":1753890053036,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2022,6,1]]},"abstract":"Background: Dexamethasone improves COVID-outcomes. Detailed glycemic profile for patients receiving dexamethasone for COVID-is lacking.<\/jats:p>\n Methods: Our hospital recommends routine blood glucose monitoring for patients with COVID-receiving dexamethasone 6mg daily. Subjects without prior history of diabetes admitted in a non-critical care setting over a 1-month period were identified and evaluated. The primary outcome was hyperglycemia post-dexamethasone, defined as glucose \u226510mmol\/L.<\/jats:p>\n Results: Of 277 subjects (52% male, age 52\u00b118 yrs, weight 90\u00b126 kg, 7% with newly diagnosed diabetes [HbA1c \u22656.5%]) , hyperglycemia post-dexamethasone occurred in 51%, with peak glucose 12.4\u00b12.3 (mean 2.2 tests\/day) . Glucose excursions peaked 7-9 hours post-dexamethasone (figure) . Hyperglycemic subjects were older (58\u00b117 vs. 45\u00b17 yrs, p&lt;0.001) , had higher HbA1c (6.1\u00b11.0 vs. 5.6\u00b10.9%, p&lt;0.001) , higher initial venous glucose (6.7\u00b11.7 vs. 6.0\u00b11.5mmol\/L, p&lt;0.001) , lower initial eGFR (80\u00b118 vs. 84\u00b115mL\/min\/m2, p=0.02) , higher initial CRP (969\u00b1640 vs. 791\u00b1558nmol\/L, p=0.01) and greater mortality (7.7 vs. 1.5%, p=0.01) . Age, HbA1c and CRP were independent predictors of hyperglycemia.<\/jats:p>\n Conclusions: Dexamethasone led to hyperglycemia in half of patients without prior diabetes admitted with COVID-19, with peak occurring 7-9 hours after dexamethasone. Older age, higher HbA1c and initial CRP predicted development of hyperglycemia.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n Y.J.Rhou: None. A.Hor: None. M.Wang: None. Y.Wu: None. D.R.Chipps: None. N.Cheung: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db22-266-or","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T06:12:46Z","timestamp":1653977566000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["266-OR: Dexamethasone-Induced Hyperglycemia in Nondiabetic Patients with COVID-19"],"prefix":"10.2337","volume":"71","author":[{"given":"YOON JI J.","family":"RHOU","sequence":"first","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AMANDA","family":"HOR","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAWSON","family":"WANG","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YU-FANG","family":"WU","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID R.","family":"CHIPPS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. WAH","family":"CHEUNG","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/266-OR\/146557\/266-OR-Dexamethasone-Induced-Hyperglycemia-in","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/266-OR\/146557\/266-OR-Dexamethasone-Induced-Hyperglycemia-in","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T06:12:46Z","timestamp":1653977566000},"score":7.7336106,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/266-OR\/146557\/266-OR-Dexamethasone-Induced-Hyperglycemia-in"}},"issued":{"date-parts":[[2022,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db22-266-or","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2022,6,1]]},"article-number":"266-OR"},{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T04:11:56Z","timestamp":1747368716108,"version":"3.40.5"},"reference-count":0,"publisher":"Clinical Exercise Physiology Association","issue":"s2","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2024,5]]},"abstract":"\n INTRODUCTION AND AIMS<\/jats:title>\n Rehabilitation following total knee arthroplasty (TKA) is essential to mitigate delay in physical recovery and facilitate optimum patient outcomes. Telehealth is emerging as a cost-effective and efficacious delivery method. The aim of this study was to investigate the early post-operative outcomes of patients following a telehealth-delivered rehabilitation program (Tele) compared with those following conventional outpatient rehabilitation (Clinic) in patients following TKA.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n A single-blinded, randomized controlled non-inferiority trial was conducted, with 108 participants scheduled for primary TKA randomly allocated to a 6-week, telehealth-delivered rehabilitation program (n=54) or a 6-week supervised, in-person rehabilitation program (n=54). Knee flexion range of motion (KF-ROM) and the Quality of Life subscale of the Knee Injury and Osteoarthritis Outcome Score (KOOS-QOL) were collected pre-surgery and 7-weeks post-surgery. A linear mixed-effect model was used to assess differences between groups over time for both outcome measures. Change in KOOS-QOL of greater than 10 points was used to establish minimally clinically important change (MCIC), with chi square analyses used to assess between-group differences.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Baseline KF-ROM measures were 124.1\u00b0 and 122.2\u00b0 for telehealth-delivered and in-person groups respectively; and 108.7\u00b0 and 111.6\u00b0 at 7-week post-surgery. KOOS-QOL scores were 32.7 and 33.3 at baseline for the respective groups; and 60.9 and 62.9 at week-7. There were no significant differences in between group changes over time for both KF-ROM (mean difference = -2.9\u00b0, 95% CI = -7.7 to 1.8; p=0.226) and KOOS-QOL (mean difference = -2.1, 95% CI: -10.0 to 5.9; p=0.611). Chi square analyses revealed no differences between groups meeting the MCIC (Tele = 71%; Clinic = 79%) in KF-ROM (X2<\/jats:sup> = 0.78, p = 0.377).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n Short term outcomes following TKA are not different between telehealth-delivered and conventional supervised rehabilitation. Telehealth may provide an effective rehabilitation option for patients undergoing TKA.<\/jats:p>\n <\/jats:sec>","DOI":"10.31189\/2165-7629-13-s2.470","type":"journal-article","created":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T14:39:21Z","timestamp":1714919961000},"page":"470","source":"Crossref","is-referenced-by-count":0,"title":["EARLY POST-OPERATIVE CLINICAL OUTCOMES IN PATIENTS UNDERGOING TOTAL KNEE ARTHROPLASTY COMPARING IN-PERSON CLINIC VERSUS TELEHEALTH-DELIVERED REHABILITATION PROGRAM: A NON-INFERIORITY TRIAL"],"prefix":"10.31189","volume":"13","author":[{"given":"Mr Ray","family":"Seaby","sequence":"first","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"},{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dr Jay","family":"Ebert","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"},{"name":"HFRC, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dr Brendan","family":"Joss","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"},{"name":"HFRC, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dr Peter","family":"Edwards","sequence":"additional","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"},{"name":"Orthopaedic Research Foundation of Western Australia, Claremont, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prof Tim","family":"Ackland","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16145","container-title":["Journal of Clinical Exercise Physiology"],"link":[{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/13\/s2\/article-p470-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/jcep\/article-pdf\/13\/s2\/470\/3369486\/i2165-7629-13-s2-470.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/13\/s2\/article-p470-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/13\/s2\/article-p470-s.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:41:19Z","timestamp":1747356079000},"score":7.7327547,"resource":{"primary":{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/13\/s2\/article-p470-s.xml"}},"issued":{"date-parts":[[2024,5]]},"references-count":0,"journal-issue":{"issue":"s2"},"URL":"https:\/\/doi.org\/10.31189\/2165-7629-13-s2.470","ISSN":["2165-7629","2165-6193"],"issn-type":[{"type":"electronic","value":"2165-7629"},{"type":"print","value":"2165-6193"}],"published":{"date-parts":[[2024,5]]}},{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:55:21Z","timestamp":1774277721927,"version":"3.50.1"},"reference-count":68,"publisher":"Australian Society of Exploration Geophysicists","issue":"5","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,9,2]]},"DOI":"10.1080\/08123985.2023.2246492","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T01:54:29Z","timestamp":1692237269000},"page":"466-485","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["Application of audio-frequency magnetotelluric data to cover characterisation \u2013 validation against borehole petrophysics in the East Tennant region, Northern Australia"],"prefix":"10.63929","volume":"55","author":[{"given":"Wenping","family":"Jiang","sequence":"first","affiliation":[{"name":"Geoscience Australia, , Canberra, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian C.","family":"Roach","sequence":"additional","affiliation":[{"name":"MinEx CRC, , Kensington, , Australia"},{"name":"Geoscience Australia, , Canberra, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Doublier","sequence":"additional","affiliation":[{"name":"Geoscience Australia, , Canberra, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingming","family":"Duan","sequence":"additional","affiliation":[{"name":"Geoscience Australia, , Canberra, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Schofield","sequence":"additional","affiliation":[{"name":"Geoscience Australia, , Canberra, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Clark","sequence":"additional","affiliation":[{"name":"Geoscience Australia, , Canberra, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross C.","family":"Brodie","sequence":"additional","affiliation":[{"name":"Geoscience Australia, , Canberra, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"53371","reference":[{"key":"e_1_3_3_2_1","first-page":"1","volume-title":"Geology and mineral resources of the northern territory. 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Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534717313915?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534717313915?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2017.02.1167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T04:50:13Z","timestamp":1651207813000},"score":7.7316136,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2017.02.1167"}},"issued":{"date-parts":[[2017,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1016\/j.juro.2017.02.1167"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2017.02.1167","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2017,4]]}},{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T07:33:10Z","timestamp":1764055990646,"version":"3.45.0"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T00:00:00Z","timestamp":1746316800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pregnancy"],"published-print":{"date-parts":[[2025,5]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Accurate detection of fetal acidosis in labor is an unmet clinical need. Objectives of this study are:<\/jats:p>\n \n \n \n To run a pilot validation of a subcutaneous biosensor for continuous lactate monitoring (CLM) to detect acidosis in a fetal lamb model of asphyxia.<\/jats:p>\n <\/jats:list-item>\n \n Assess the feasibility of the CLM biosensor for intrapartum fetal monitoring by correlating sensor\u2010detected lactate levels with contemporaneously collected blood lactate values.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n Ewes (\n n<\/jats:italic>\n \u00a0=\u00a03) with singleton pregnancy were anesthetized and the lamb's head was exteriorized. Multiple biosensors were placed onto the lamb scalp, with electrical current outputs captured. Jugular venous blood samples were collected at regular intervals across the protocol, and lactate and other physiological parameters were recorded. After baseline, the umbilical cord was occluded for 10 min, with recordings continuing over at least 3 h during recovery.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Nine biosensors were tested across three animals. Six of the nine had a clear response to lactate rise from an acute hypoxic event, with five of these having strong correlation (\n R<\/jats:italic>\n 2<\/jats:sup>\n \u00a0>\u00a00.93). These five sensors responded to change in venous lactate from as low as 1.6\u00a0mmol\/L up to 8.4\u00a0mmol\/L over a range of pH (7.04\u20107.38) and p\n v<\/jats:sub>\n O\n 2<\/jats:sub>\n (1.6\u201023.5\u00a0mmHg) over 5.5\u00a0h, demonstrating the utility of the biosensor in monitoring in\u2010vivo lactate levels.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study demonstrates the capability of an innovative subcutaneous biosensor for CLM in detecting early signs of fetal lactic acidosis, highlighted by the strong correlation between sensor current and venous blood lactate levels. This technology has the potential to enable continuous fetal lactate measurement, with the ability to revolutionize intrapartum care and improve neonatal outcomes by enabling crucial early detection and management of fetal asphyxia during labor and delivery.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/pmf2.70017","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T02:17:47Z","timestamp":1746411467000},"source":"Crossref","is-referenced-by-count":0,"title":["Preclinical development of a continuous fetal lactate biosensor to detect acidosis"],"prefix":"10.1002","volume":"1","author":[{"given":"Maureen T.","family":"Ross","sequence":"first","affiliation":[{"name":"VitalTrace Pty Ltd Malaga Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaitya","family":"Shah","sequence":"additional","affiliation":[{"name":"VitalTrace Pty Ltd Malaga Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayley","family":"Powell","sequence":"additional","affiliation":[{"name":"The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Kershaw","sequence":"additional","affiliation":[{"name":"The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjusha","family":"Rajagopalan","sequence":"additional","affiliation":[{"name":"VitalTrace Pty Ltd Malaga Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Mahmood","sequence":"additional","affiliation":[{"name":"VitalTrace Pty Ltd Malaga Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allana","family":"Gurney","sequence":"additional","affiliation":[{"name":"The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. Jane","family":"Choi","sequence":"additional","affiliation":[{"name":"The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle","family":"Musk","sequence":"additional","affiliation":[{"name":"The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Challenor","sequence":"additional","affiliation":[{"name":"VitalTrace Pty Ltd Malaga Western Australia Australia"},{"name":"The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjun","family":"Kaushik","sequence":"additional","affiliation":[{"name":"VitalTrace Pty Ltd Malaga Western Australia Australia"},{"name":"The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Morris","sequence":"additional","affiliation":[{"name":"VitalTrace Pty Ltd Malaga Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee J.","family":"Hubble","sequence":"additional","affiliation":[{"name":"VitalTrace Pty Ltd Malaga Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Jane","family":"Pillow","sequence":"additional","affiliation":[{"name":"VitalTrace Pty Ltd Malaga Western Australia Australia"},{"name":"The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.07.032"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/02724936.1991.11747524"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.148205"},{"issue":"9","key":"e_1_2_8_6_1","first-page":"2487","article-title":"Interpretation of the Electronic Fetal Heart Rate During Labor","volume":"59","author":"Sweha A.","year":"1999","journal-title":"American Family Physician"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i6405"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2006.093"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xagr.2021.100008"},{"key":"e_1_2_8_10_1","article-title":"Fetal Pulse Oximetry for Fetal Assessment in Labour","volume":"10","author":"East C. E.","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Pregnancy"],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmf2.70017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T07:29:05Z","timestamp":1764055745000},"score":7.7310038,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pmf2.70017"}},"issued":{"date-parts":[[2025,5]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/pmf2.70017"],"URL":"https:\/\/doi.org\/10.1002\/pmf2.70017","archive":["Portico"],"ISSN":["2997-9684","2997-9684"],"issn-type":[{"type":"print","value":"2997-9684"},{"type":"electronic","value":"2997-9684"}],"published":{"date-parts":[[2025,5]]},"article-number":"e70017"},{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:03:56Z","timestamp":1780700636736,"version":"3.54.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2026,6,5]]},"abstract":"Introduction and Objective: Cognitive changes in older adults with Type 1 diabetes (T1D) can impact daily self-management tasks for diabetes, but are not consistently detected. We aimed to compare performance on three cognitive screening tools against a standardised clinical neuropsychology assessment. We also evaluated whether subjective cognitive concerns could help identify individuals who need formal cognitive testing.<\/jats:p>\n Methods: Forty-two adults with T1D aged \u226555 years completed the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Addenbrooke\u2019s Cognitive Examination-III (ACE-III), Cognitive Change Index (CCI - self and informant versions) and neuropsychological tests, all via telehealth. Cognitive impairment was defined as \u22651.5 SD below expected levels on \u22652 neuropsychological tests, using either age-based or premorbid ability norms; using this definition as the reference standard, we performed receiver operating characteristic (ROC) analyses to evaluate screening tool performance and determine cut-off scores.<\/jats:p>\n Results: ACE-III performed best: \u226492\/100 identified all impaired cases using age-norms. MoCA at its standard was less sensitive, and MMSE missed the most. For premorbid-norms, MoCA was most useful: \u226428\/30 captured most impaired participants, whereas ACE-III required an almost perfect score for similar sensitivity, and MMSE at its standard \u226425\/30 missed over 90% of those impaired. Under both impairment definitions, high CCI scores (both self and informant) showed moderate sensitivity, but required sacrificing specificity to detect subtle premorbid decline.<\/jats:p>\n Conclusion: ACE-III is the best initial screening tool for detecting age-normed cognitive impairment in T1D, whereas MoCA is more sensitive for detecting subtle, premorbid-normed decline. Subjective cognitive change reports are valuable for triaging further cognitive testing but cannot replace objective screening.<\/jats:p>\n \n Disclosure<\/jats:title>\n L. Li: None. D. Wong: None. C.A. Fisher: None. J.J. Conn: None. S. Fourlanos: Speaker's Bureau; Ended; Boehringer Ingelheim International GmbH, Novo Nordisk, AstraZeneca. Research Support; Current; Dexcom, Inc. P. Wraight: None. K. Pike: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db26-1624-p","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:37:35Z","timestamp":1780699055000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1624-P: Cognitive Screening in Older Adults with Type 1 Diabetes: Which Tools Best Detect Potential Cognitive Decline?"],"prefix":"10.2337","volume":"75","author":[{"given":"LILY","family":"LI","sequence":"first","affiliation":[{"name":"Bundoora, Australia, Parkville, Australia, Gold Coast, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DANA","family":"WONG","sequence":"additional","affiliation":[{"name":"Bundoora, Australia, Parkville, Australia, Gold Coast, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CAROLINE A.","family":"FISHER","sequence":"additional","affiliation":[{"name":"Bundoora, Australia, Parkville, Australia, Gold Coast, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JENNIFER J.","family":"CONN","sequence":"additional","affiliation":[{"name":"Bundoora, Australia, Parkville, Australia, Gold Coast, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SPIROS","family":"FOURLANOS","sequence":"additional","affiliation":[{"name":"Bundoora, Australia, Parkville, Australia, Gold Coast, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PAUL","family":"WRAIGHT","sequence":"additional","affiliation":[{"name":"Bundoora, Australia, Parkville, Australia, Gold Coast, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KERRYN","family":"PIKE","sequence":"additional","affiliation":[{"name":"Bundoora, Australia, Parkville, Australia, Gold Coast, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/1624-P\/169114\/1624-P-Cognitive-Screening-in-Older-Adults-with","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/1624-P\/169114\/1624-P-Cognitive-Screening-in-Older-Adults-with","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:37:35Z","timestamp":1780699055000},"score":7.7298346,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/1624-P\/169114\/1624-P-Cognitive-Screening-in-Older-Adults-with"}},"issued":{"date-parts":[[2026,6,5]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2026,6,5]]}},"URL":"https:\/\/doi.org\/10.2337\/db26-1624-p","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2026,6,5]]},"article-number":"1624-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:38:10Z","timestamp":1753889890592,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Objective: Diabetes screening and management guidelines have changed over the last 15 years. We compared diabetes prevalence, management, metabolic control and complications in 2 surveys, conducted 15 years apart.<\/jats:p>\n Methods: Repeat cross-sectional studies 2001-2003 (XRDS1) and 2016-2018 (XRDS2) across 4 rural Australian towns with previously low access to primary care, involving a household survey followed by biomedical assessments (including OGTTs) among randomly selected individuals.<\/jats:p>\n Results: Overall, household survey\/clinic responses were &gt;60% involving 4464\/1042 and 2315\/748 residents in XRDS1 and 2 respectively. The prevalence of known diabetes increased overall (5.4% to 10.4% p&lt;0.001), in those &lt;50, 50-59, 70+ years; but not 60-69 years (2.5% vs. 4.8% p&lt;0.001, 6.5% vs. 9.7% p&lt;0.05, 9.9% vs. 18.4% p&lt;0.001; 12.8% vs.13.4%). Proportions with undiagnosed diabetes and IFG\/IGT were not significantly different (2.3% vs. 1.5%; 11.7% vs. 10.0%). Diabetes screening increased from 48.9% to 59.5% (p&lt;0.001). Among those with known diabetes age (59\u00b116 vs. 63\u00b116 p&lt;0.01), lipid testing (84.8% vs. 92.8% p&lt;0.05), hypertension (52.2% vs. 65.8% p&lt;0.01) and dyslipidaemia (21.9% vs. 55.8% p&lt;0.001) diagnoses, increased. Age at diagnosis (53\u00b115 vs. 52\u00b116 years), BMI (30.4\u00b16.9 vs. 30.8\u00b17.1 kg\/m2), glycaemia testing (97.1 vs. 95.3%) and BP testing (98.4% vs. 98.2%) were similar. Mean HbA1c and diastolic BP were similar but systolic BP (143\u00b124 vs. 136\u00b119 mm Hg p&lt;0.05) and total cholesterol (4.8\u00b10.9 vs. 4.4\u00b11.1 mmol\/l p&lt;0.05) were lower. Complication rates were similar (nephropathy 27.8% vs. 22.4%, non-fatal stroke 6.2% vs. 5.0%) or increased (depression 14.1% vs. 33.5% p&lt;0.01; cardiac condition 24.1% vs. 32.4% p&lt;0.05).<\/jats:p>\n Conclusions: Over 15 years, diabetes prevalence increased, CVD risk management improved but complications were unchanged or increased. Further work is required to understand the extent to which changing survival, migration, access to care and ageing have contributed to these patterns.<\/jats:p>\n \n Disclosure<\/jats:title>\n D. Simmons: Speaker's Bureau; Self; Sanofi-Aventis. Other Relationship; Self; Medtronic. K. Glenister: None. D.J. Magliano: None. L. Bourke: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Health and Medicine Research Council of Australia<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-1629-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T01:26:26Z","timestamp":1559697986000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1629-P: Changes in the Prevalence of Diabetes, Its Management, and Complications over 15 Years in a Rural Australian Population"],"prefix":"10.2337","volume":"68","author":[{"given":"DAVID","family":"SIMMONS","sequence":"first","affiliation":[{"name":"Campbelltown, Australia, Wangaratta, Australia, Melbourne, Australia, Shepparton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KRISTEN","family":"GLENISTER","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Wangaratta, Australia, Melbourne, Australia, Shepparton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DIANNA J.","family":"MAGLIANO","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Wangaratta, Australia, Melbourne, Australia, Shepparton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LISA","family":"BOURKE","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Wangaratta, Australia, Melbourne, Australia, Shepparton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1629-P\/59540\/1629-P-Changes-in-the-Prevalence-of-Diabetes-Its","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1629-P\/59540\/1629-P-Changes-in-the-Prevalence-of-Diabetes-Its","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:03:55Z","timestamp":1647165835000},"score":7.726944,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1629-P\/59540\/1629-P-Changes-in-the-Prevalence-of-Diabetes-Its"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-1629-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"1629-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:41Z","timestamp":1753890041585,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2021,6,1]]},"DOI":"10.2337\/db21-1198-p","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T22:14:51Z","timestamp":1624572891000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1198-P: Sex Hormone Binding Globulin (SHBG) as an Indicator of Reduced Insulin Sensitivity in Type 1 Diabetes (T1D) Adults and a Potential Tool to Guide Adjunct Therapy"],"prefix":"10.2337","volume":"70","author":[{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"first","affiliation":[{"name":"Sydney, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WAYNE","family":"RANKIN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GARY A.","family":"WITTERT","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Adelaide, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/1198-P\/140695\/1198-P-Sex-Hormone-Binding-Globulin-SHBG-as-an","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/1198-P\/140695\/1198-P-Sex-Hormone-Binding-Globulin-SHBG-as-an","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T11:42:06Z","timestamp":1647171726000},"score":7.7269244,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/1198-P\/140695\/1198-P-Sex-Hormone-Binding-Globulin-SHBG-as-an"}},"issued":{"date-parts":[[2021,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db21-1198-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2021,6,1]]},"article-number":"1198-P"},{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:07:27Z","timestamp":1780704447900,"version":"3.54.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2026,6,5]]},"abstract":"Introduction and Objective: Early pregnancy insulin resistance (eIR) increases risk of gestational diabetes (GDM). We compared early (eGDM) and late GDM (lGDM) in their relationship with eIR.<\/jats:p>\n Methods: Pregnant women with GDM risk factors enrolled in a multicenter RCT had a 75g OGTT before 20w using IADPSG criteria, with fasting serum insulin measured. Repeat OGTT occurred at 24-28w if OGTT was normal and in 50% of those with eGDM. Homeostatic Model Assessment (HOMA)-IR (Glucose x Insulin)\/22.5) values were log-transformed and standardized to a z score to estimate odds ratios (OR(95% CI)) per 1-SD increase in log-HOMA. Logistic binomial regression was used to adjust the OR of GDM for confounders. A non-linear association between HOMA-IR and GDM was assessed by adding a squared term for HOMA-IR. Area under the receiver operator curve (AUROC) with 95% CI was used for eGDM and lGDM prediction.<\/jats:p>\n Results: Among 1225 women (mean age 32\u00b15y, BMI 29.6\u00b17.8 kg\/m2, OGTT gestation 15\u00b12w, 43.3% European), mean HOMA-IR (1.44\u00b11.86 for no-GDM) was 2.44\u00b12.08 for eGDM and 1.58\u00b11.85 for lGDM (p&lt;0.001). The OR for eGDM and lGDM were 2.09 (1.82-2.40) and 1.39 (1.17-1.65) per 1-SD increase in HOMA-IR respectively with adjusted OR 2.03(1.69-2.42) and 1.45 (1.15-1.82). The association was nonlinear for eGDM (p=0.002) but linear for lGDM (fig 1). The AUROC was significantly higher for eGDM than lGDM (0.71 (95% CI 0.68-0.74) vs 0.60(0.56-0.64)).<\/jats:p>\n Conclusion: Early pregnancy insulin resistance is a stronger predictor of eGDM than lGDM.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n D. Simmons: Speaker's Bureau; Ended; Novo Nordisk. Other - Educational grant; Ended; Abbott Diabetes. Research Support; Current; Novo Nordisk. Consultant; Ended; Dexcom, Inc. A. Sweeting: None. J. Immanuel: None. M. Hivert: None. V.W. Wong: None. J. Harreiter: None. W.M. Hague: None. N. Pham: None. C. Nolan: None. N. Cheung: Other - honorarium for speakership; Ended; AstraZeneca. V. Mohan: None. A. Kautzky-Willer: None. M.J. Peek: None. E. Gianatti: None. A.A. Hardikar: None. M.V. Joglekar: None. H.E. Backman: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n NHMRC (grants 1104231 and 2009326); Region \u00d6rebro Research Committee DnrOLL-970566, OLL-942177; Medical Scientific Fund of the Mayor of Vienna, project 15205; SouthWestern Sydney Local Health District Academic Unit grant 2016; Western Sydney University AinsworthTrust grant 2019<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db26-2156-p","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:56:26Z","timestamp":1780703786000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["2156-P: Early Insulin Resistance Is a Stronger Predictor of Early than Late Gestational Diabetes"],"prefix":"10.2337","volume":"75","author":[{"given":"DAVID","family":"SIMMONS","sequence":"first","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ARIANNE","family":"SWEETING","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JINCY","family":"IMMANUEL","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIE-FRANCE","family":"HIVERT","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VINCENT W.M.","family":"WONG","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00dcRGEN","family":"HARREITER","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WILLIAM M.","family":"HAGUE","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NHAN HO TRONG","family":"PHAM","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTOPHER","family":"NOLAN","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N WAH","family":"CHEUNG","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VISWANATHAN","family":"MOHAN","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALEXANDRA","family":"KAUTZKY-WILLER","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHAEL J.","family":"PEEK","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EMILY","family":"GIANATTI","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANANDWARDHAN A.","family":"HARDIKAR","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MUGDHA V.","family":"JOGLEKAR","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HELENA E.","family":"BACKMAN","sequence":"additional","affiliation":[{"name":"Penrith, Australia, Sydney, Australia, Hickory Creek, TX, Boston, MA, Liverpool, Australia, Scheibbs, Austria, North Adelaide, Australia, Woden, Australia, Westmead, Australia, Chennai, India, Vienna, Austria, Kingswood, Australia, Murdoch, Australia, Campbelltown, Australia, Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"TOBOGM RESEARCH GROUP","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/2156-P\/168383\/2156-P-Early-Insulin-Resistance-Is-a-Stronger","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/2156-P\/168383\/2156-P-Early-Insulin-Resistance-Is-a-Stronger","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:56:26Z","timestamp":1780703786000},"score":7.7252607,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/2156-P\/168383\/2156-P-Early-Insulin-Resistance-Is-a-Stronger"}},"issued":{"date-parts":[[2026,6,5]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2026,6,5]]}},"URL":"https:\/\/doi.org\/10.2337\/db26-2156-p","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2026,6,5]]},"article-number":"2156-P"},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:43:03Z","timestamp":1651210983092},"reference-count":0,"publisher":"Ovid 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Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534718409834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534718409834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2018.02.1673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:27:34Z","timestamp":1651210054000},"score":7.7239623,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2018.02.1673"}},"issued":{"date-parts":[[2018,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1016\/j.juro.2018.02.1673"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2018.02.1673","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2018,4]]}},{"indexed":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:23:05Z","timestamp":1741753385779,"version":"3.38.0"},"reference-count":0,"publisher":"SAGE 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Psychiatry"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1046\/j.1440-1665.2003.02045.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1046\/j.1440-1665.2003.02045.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1046\/j.1440-1665.2003.02045.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T06:50:29Z","timestamp":1741675829000},"score":7.723607,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1046\/j.1440-1665.2003.02045.x"}},"issued":{"date-parts":[[2003,12]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["10.1046\/j.1440-1665.2003.02045.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1440-1665.2003.02045.x","ISSN":["1039-8562","1440-1665"],"issn-type":[{"type":"print","value":"1039-8562"},{"type":"electronic","value":"1440-1665"}],"published":{"date-parts":[[2003,12]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:44Z","timestamp":1753890044049,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2022,6,1]]},"abstract":"Hospitalization for diabetes-related foot disease adds considerable burden for people living with diabetes and often leads to lower extremity amputation. We evaluated trends in the incidence of foot disease related hospital admission, revascularization and amputation procedures among people with type 1 and type 2 diabetes in Australia from 2010-2019. We included 70,766 people with type 1, and 1.1 million people with type 2 diabetes from the Australian diabetes registry (55% male) . We linked the diabetes registry to hospital admissions data to obtain the number of hospital admissions for foot disease, revascularization and amputation procedures. We estimated the annual incidence rates, using people with diabetes as the denominator, and evaluated trends over time with Joinpoint regression. In type 1 diabetes, rates of admission for foot disease and revascularization increased, while amputation rates were relatively stable (Table) . In type 2 diabetes, rates of foot disease admission and revascularization increased. While above the knee amputations decreased, below the knee amputations were stable, and foot and toe amputations increased. Average annual percent changes were generally higher for men than women (i.e. men showed greater increases or less of a decrease over time) . These findings highlight the importance of improving management of diabetes-related foot disease.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n M.Quigley: None. J.I.Morton: None. P.A.Lazzarini: None. J.E.Shaw: Advisory Panel; Abbott Diagnostics, AstraZeneca, Eli Lilly and Company, Pfizer Inc., Roche Diagnostics, Research Support; AstraZeneca, Boehringer Ingelheim International GmbH, Speaker's Bureau; AstraZeneca, Eli Lilly and Company, Novo Nordisk, Sanofi. D.J.Magliano: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n MQ is supported by an Australian Government Research Training Program (RTP) Scholarship. JIM is supported by an Australian Government Research Training Program (RTP) Scholarship and Monash Graduate Excellence Scholarship. PAL is supported by a National Health and Medical Research Council Early Career Fellowship. JES is supported by a National Health and Medical Research Council Investigator Grant. DJM is supported by a National Health and Medical Research Council Senior Research Fellowship. This work is partially supported by the Victorian Government\u2019s Operational Infrastructure Support Program.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db22-1147-p","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T06:15:14Z","timestamp":1653977714000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1147-P: Trends in Diabetes-Related Foot Disease Hospitalization, Revascularization, and Amputations in Australia 20to 2019"],"prefix":"10.2337","volume":"71","author":[{"given":"MATTHEW","family":"QUIGLEY","sequence":"first","affiliation":[{"name":"Melbourne, Victoria, Australia, Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEDIDIAH I.","family":"MORTON","sequence":"additional","affiliation":[{"name":"Melbourne, Victoria, Australia, Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER A.","family":"LAZZARINI","sequence":"additional","affiliation":[{"name":"Melbourne, Victoria, Australia, Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JONATHAN E.","family":"SHAW","sequence":"additional","affiliation":[{"name":"Melbourne, Victoria, Australia, Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DIANNA J.","family":"MAGLIANO","sequence":"additional","affiliation":[{"name":"Melbourne, Victoria, Australia, Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/1147-P\/146598\/1147-P-Trends-in-Diabetes-Related-Foot-Disease","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/1147-P\/146598\/1147-P-Trends-in-Diabetes-Related-Foot-Disease","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T06:15:14Z","timestamp":1653977714000},"score":7.723144,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/1147-P\/146598\/1147-P-Trends-in-Diabetes-Related-Foot-Disease"}},"issued":{"date-parts":[[2022,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db22-1147-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2022,6,1]]},"article-number":"1147-P"},{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:05:31Z","timestamp":1766138731463,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,6,14]]},"abstract":"Aim: To compare glycemic test characteristics for predicting GDM at 24-28 weeks\u2019 gestation (LGDM) among those with a normal OGTT &lt;20 weeks\u2019 gestation.<\/jats:p>\n Methods: Pregnant women with GDM risk factors were enrolled into a multicenter early GDM (EGDM) treatment trial. Women with EGDM are excluded from this analysis. A 2-h 75g OGTT with HbA1c occurred on entry. The OGTT was repeated at 24-28 weeks\u2019 gestation. GDM was defined by WHO 2013 criteria. Receiver Operator Curve (ROC) assessment compared early fasting (FBG), 1-h (1HBG), 2-h (2HBG) glucose and HbA1c prediction of LGDM. ROCs[95%CI] were calculated within European, Asian\/Pasifika and other ethnic groups. The proportions with LGDM \u226590th and &lt;90th centile, and their odds ratio (OR [95%CI]) using Mantel-Haenszel testing were calculated for each early glycemic test and a composite of any OGTT measure\u226590th centile (F12BG).<\/jats:p>\n Results: Those with LGDM (n=467) vs no GDM (n=2218) were older (31.4\u00b14.9 vs 30.7\u00b15.1 yrs p=0.009), more likely to be overweight\/obese (67.0% vs 57.3% p&lt;0.001), non-European (63.6% vs 57.0% p=0.030) and to have a diabetes family history (52.1% vs 40.7% p&lt;0.001). The ROCs for early FBG, 1HBG, 2HBG, HbA1c were 0.63[0.60-0.66], 0.73[0.70-0.76], 0.66[0.63-0.69], 0.63[0.60-0.66] respectively. ROC patterns were similar across ethnic groups. The \u226590th centile cut-offs (FBG, 1HBG, 2HBG, HbA1c) were \u22654.9 mmol\/l, \u22658.8 mmol\/l, \u22657.3 mmol\/l; \u22655.3% including 11.1%, 10.4%, 10.1%, 15.0% of the cohort. The F12BG composite included 34.0% of the cohort. Comparing \u226590th centile vs &lt;90th centile, LGDM was present in 32.6% vs 15.4%, 47.3% vs 13.9%, 36.4% vs 15.3%, 30.1% vs 14.6%, 35.3% vs 11.4% across the 5 measures with OR of 2.6[2.0-3.4], 5.6[4.3-7.2], 3.2[2.4-4.2], 2.5[2.0-3.2], 4.2[3.4-5.2] respectively. Sensitivities were 21.4%, 28.3%, 21.2%, 27.7%, 50.7% respectively.<\/jats:p>\n Conclusions: After excluding those with EGDM, the 1HBG was the best single test, but no single or combined early glycemic measure was sufficiently discriminatory to avoid the second OGTT.<\/jats:p>\n \n Disclosure<\/jats:title>\n D. Simmons: Speaker's Bureau; Abbott. Consultant; Sanofi. Speaker's Bureau; Ascensia Diabetes Care. Other Relationship; Ascensia Diabetes Care, Boehringer-Ingelheim. Research Support; Dexcom, Inc. Speaker's Bureau; Novo Nordisk. Research Support; Wests Club, NSW, Australia, Roche Diabetes Care. W. Hague: None. A. Sweeting: None. N. Cheung: None. C.J. Nolan: None. H. Teede: None. M.J. Peek: None. A. Kautzky-Willer: None. E. Hibbert: None. H.E. Fadl: None. V.W.M. Wong: None. J. Harreiter: None. J. Immanuel: None. E.J. Gianatti: None. V. Mohan: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Health and Medical Research Council (grants 1104231 and 2009326), the Region \u00d6rebro Research Committee (grants Dnr OLL-970566 and OLL-942177), Medical Scientific Fund of the Mayor of Vienna (project numbers 15205 and 23026), the South Western Sydney Local Health District Academic Unit (grant 2016), and a Western Sydney University Ainsworth Trust Grant (2019).<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db24-202-or","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T06:34:06Z","timestamp":1718346846000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["202-OR: Prediction of Late Gestational Diabetes Mellitus in Those without Early GDM"],"prefix":"10.2337","volume":"73","author":[{"given":"DAVID","family":"SIMMONS","sequence":"first","affiliation":[{"name":"Campbelltown NSW, Australia, North Adelaide, Australia, SYDNEY, Australia, Woden, Australia, Melbourne, Australia, Canberra, Australia, Vienna, Austria, Kingswood, Australia, \u00d6rebro, Sweden, Liverpool, Australia, Campbelltowm, Australia, Palmyra DC, Australia, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WILLIAM","family":"HAGUE","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, North Adelaide, Australia, SYDNEY, Australia, Woden, Australia, Melbourne, Australia, Canberra, Australia, Vienna, Austria, Kingswood, Australia, \u00d6rebro, Sweden, Liverpool, Australia, Campbelltowm, Australia, Palmyra DC, Australia, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ARIANNE","family":"SWEETING","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, North Adelaide, Australia, SYDNEY, Australia, Woden, Australia, Melbourne, Australia, Canberra, Australia, Vienna, Austria, Kingswood, Australia, \u00d6rebro, Sweden, Liverpool, Australia, Campbelltowm, Australia, Palmyra DC, Australia, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"WAH CHEUNG","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, North Adelaide, Australia, SYDNEY, Australia, Woden, Australia, Melbourne, Australia, Canberra, Australia, Vienna, Austria, Kingswood, Australia, \u00d6rebro, Sweden, Liverpool, Australia, Campbelltowm, Australia, Palmyra DC, Australia, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTOPHER J.","family":"NOLAN","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, North Adelaide, Australia, SYDNEY, Australia, Woden, Australia, Melbourne, Australia, Canberra, Australia, Vienna, Austria, Kingswood, Australia, \u00d6rebro, Sweden, Liverpool, Australia, Campbelltowm, Australia, Palmyra DC, Australia, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HELENA","family":"TEEDE","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, North Adelaide, Australia, SYDNEY, Australia, Woden, Australia, Melbourne, Australia, Canberra, Australia, Vienna, Austria, Kingswood, Australia, \u00d6rebro, Sweden, Liverpool, Australia, Campbelltowm, Australia, Palmyra DC, Australia, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL J.","family":"PEEK","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, North Adelaide, Australia, SYDNEY, Australia, Woden, Australia, Melbourne, Australia, Canberra, Australia, Vienna, Austria, Kingswood, Australia, \u00d6rebro, Sweden, Liverpool, Australia, Campbelltowm, Australia, Palmyra DC, Australia, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALEXANDRA","family":"KAUTZKY-WILLER","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, North Adelaide, Australia, SYDNEY, Australia, Woden, Australia, Melbourne, Australia, Canberra, Australia, Vienna, Austria, Kingswood, Australia, \u00d6rebro, Sweden, Liverpool, Australia, Campbelltowm, Australia, Palmyra DC, Australia, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EMILY","family":"HIBBERT","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, North Adelaide, Australia, SYDNEY, Australia, Woden, Australia, Melbourne, Australia, Canberra, Australia, Vienna, Austria, Kingswood, Australia, \u00d6rebro, Sweden, Liverpool, Australia, Campbelltowm, Australia, Palmyra DC, Australia, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HELENA 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Woden, Australia, Melbourne, Australia, Canberra, Australia, Vienna, Austria, Kingswood, Australia, \u00d6rebro, Sweden, Liverpool, Australia, Campbelltowm, Australia, Palmyra DC, Australia, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JINCY","family":"IMMANUEL","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, North Adelaide, Australia, SYDNEY, Australia, Woden, Australia, Melbourne, Australia, Canberra, Australia, Vienna, Austria, Kingswood, Australia, \u00d6rebro, Sweden, Liverpool, Australia, Campbelltowm, Australia, Palmyra DC, Australia, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EMILY J.","family":"GIANATTI","sequence":"additional","affiliation":[{"name":"Campbelltown NSW, Australia, North Adelaide, Australia, SYDNEY, Australia, Woden, Australia, Melbourne, Australia, Canberra, Australia, Vienna, Austria, Kingswood, Australia, \u00d6rebro, Sweden, Liverpool, Australia, 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India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/202-OR\/156029\/202-OR-Prediction-of-Late-Gestational-Diabetes","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/202-OR\/156029\/202-OR-Prediction-of-Late-Gestational-Diabetes","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T06:34:06Z","timestamp":1718346846000},"score":7.722554,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/202-OR\/156029\/202-OR-Prediction-of-Late-Gestational-Diabetes"}},"issued":{"date-parts":[[2024,6,14]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2024,6,14]]}},"URL":"https:\/\/doi.org\/10.2337\/db24-202-or","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2024,6,14]]},"article-number":"202-OR"},{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:11:09Z","timestamp":1759972269738,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"S8","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2023,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Dementia prevalence and incidence in Aboriginal Australians is three to five times that of the general population. Many of the known risk factors for dementia in this population are modifiable (e.g., head injury, hypertension, previous stroke and poor mobility). However, there is currently no evidence\u2010base on how to delay or prevent cognitive decline and dementia in Aboriginal Australians. Therefore, a comprehensive program to target dementia risk factors in this population is required.<\/jats:p><\/jats:sec>Method<\/jats:title>In partnership with three Aboriginal Community Controlled Health Services (ACCHS) in Western Australia, we have developed an Aboriginal health practitioner\u2010led health program (DAMPAA) to target key dementia risk factors for Aboriginal people over 45 years. The DAMPAA program was co\u2010designed by the research team, Elders and Aboriginal community\u2010controlled organisations. Qualitative data to inform the co\u2010design was collected through ACCHS staff workshops, Elders yarning groups and interviews with DAMPAA Aboriginal and non\u2010Aboriginal researchers using a Theory of Change framework. Additionally, a small pilot study was conducted in 2020, which included participant exit interviews conducted by Aboriginal researchers. Qualitative data from all data sources was analysed thematically by a qualitative researcher, and member checked by two DAMPAA Aboriginal researchers and the Elders Governance group.<\/jats:p><\/jats:sec>Result<\/jats:title>The DAMPAA program includes group physical activity, education, goal setting and medication management. Program enablers identified by ACCHS, research staff and participants include (but not limited to) group Aboriginal community controlled organisation based walking and yarning sessions, with additional activities such as aqua aerobics, tai chi and boot scooting, a buddy system for home exercising, connecting with others, transport, healthy food, being Aboriginal led, and the ACCHS partnership. An additional enabler identified by the Elders governance group include Aboriginal language education sessions. Program barriers identified include (but not limited to) family commitments, caring for grandchildren, travel for funerals and other appointments and participant contact details changed.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The barriers and enablers identified from participants, ACCHS and DAMPAA staff have informed the development of the program protocol. DAMPAA will be evaluated through a randomised controlled trial implemented at four sites in Western Australia and process evaluation using a Theory of Change framework.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.065352","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T06:25:12Z","timestamp":1686896712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Co\u2010design of an Aboriginal Health Practitioner\u2010led dementia prevention program (DAMPAA) using a Theory of Change framework"],"prefix":"10.1002","volume":"19","author":[{"given":"Irene Mateo","family":"Arriero","sequence":"first","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Lalovic","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Hill","sequence":"additional","affiliation":[{"name":"Monash University, Melbourne, VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"LoGiudice","sequence":"additional","affiliation":[{"name":"The University of Melbourne, Melbourne, VIC Australia"},{"name":"Melbourne Health, Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay L","family":"Cox","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Milte","sequence":"additional","affiliation":[{"name":"Flinders University, Bedford Park Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Ratcliffe","sequence":"additional","affiliation":[{"name":"The University of South Australia, Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela","family":"Pestell","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glennette","family":"Dowden","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bynder","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Bulten","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynette","family":"Yappo","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley","family":"Markey","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Lin","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Woods","sequence":"additional","affiliation":[{"name":"Geraldton Regional Aboriginal Medical Service, Geraldton, Western Australia 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Aboriginal Australians ( n\u2009=\u2009203) living with hepatitis C completed a survey assessing community attachment, stigma, resilience, quality of life, treatment intent, hepatitis C knowledge and positive lifestyle changes. A stronger sense of community attachment was associated with greater resilience, increased quality of life, less hepatitis C\u2013related stigma and with increased lifestyle changes after diagnosis. Hence, community attachment can buffer against the negative health effects of stigma and may promote the resources to engage in positive behaviour changes, ultimately increasing long-term health outcomes.<\/jats:p>","DOI":"10.1177\/2055102915601581","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T22:08:59Z","timestamp":1439935739000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["The role of Aboriginal community attachment in promoting lifestyle changes after hepatitis C diagnosis"],"prefix":"10.1177","volume":"2","author":[{"given":"Loren","family":"Brener","sequence":"first","affiliation":[{"name":"UNSW Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Wilson","sequence":"additional","affiliation":[{"name":"UNSW Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L Clair","family":"Jackson","sequence":"additional","affiliation":[{"name":"UNSW Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Johnson","sequence":"additional","affiliation":[{"name":"UNSW Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Saunders","sequence":"additional","affiliation":[{"name":"UNSW Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Treloar","sequence":"additional","affiliation":[{"name":"UNSW Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,8,18]]},"reference":[{"key":"bibr1-2055102915601581","doi-asserted-by":"crossref","unstructured":"Ahern J, Stuber J, Galea S (2007) Stigma, discrimination and the health of illicit drug users. 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Open"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2055102915601581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2055102915601581","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2055102915601581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:24:08Z","timestamp":1777451048000},"score":7.721392,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2055102915601581"}},"issued":{"date-parts":[[2015,7,1]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,7,1]]}},"alternative-id":["10.1177\/2055102915601581"],"URL":"https:\/\/doi.org\/10.1177\/2055102915601581","ISSN":["2055-1029","2055-1029"],"issn-type":[{"value":"2055-1029","type":"print"},{"value":"2055-1029","type":"electronic"}],"published":{"date-parts":[[2015,7,1]]},"article-number":"2055102915601581"},{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T09:52:59Z","timestamp":1773568379689,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"10S","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.arthro.2011.08.159","type":"journal-article","created":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T09:43:51Z","timestamp":1318239831000},"source":"Crossref","is-referenced-by-count":0,"title":["Paper # 159: A Randomized Comparison of Traditional and Accelerated Approaches to Post\u2010operative Rehabilitation following Matrix\u2010induced Autologous Chondrocyte Implantation (MACI)"],"prefix":"10.1002","volume":"27","author":[{"given":"Jay Robert","family":"Ebert","sequence":"first","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fallon","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Robertson","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lloyd","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia 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University Press (OUP)","issue":"suppl_1","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2017,7,1]]},"DOI":"10.1093\/geroni\/igx004.5166","type":"journal-article","created":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T10:38:57Z","timestamp":1498905537000},"page":"1403-1403","source":"Crossref","is-referenced-by-count":0,"title":["WHY AREN\u2019T PEOPLE WITH YOUNG ONSET DEMENTIA AND THEIR CAREGIVERS USING FORMAL SERVICES?"],"prefix":"10.1093","volume":"1","author":[{"given":"M.","family":"Cations","sequence":"first","affiliation":[{"name":"UNSW Australia, Sydney, South Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Withall","sequence":"additional","affiliation":[{"name":"UNSW Australia, Sydney, South Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"White","sequence":"additional","affiliation":[{"name":"University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Trollor","sequence":"additional","affiliation":[{"name":"UNSW Australia, Sydney, South Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Loy","sequence":"additional","affiliation":[{"name":"University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Gonski","sequence":"additional","affiliation":[{"name":"UNSW Australia, Sydney, South Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Brodaty","sequence":"additional","affiliation":[{"name":"UNSW Australia, Sydney, South Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Draper","sequence":"additional","affiliation":[{"name":"UNSW Australia, Sydney, South Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,6,30]]},"container-title":["Innovation in Aging"],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/innovateage\/article-pdf\/1\/suppl_1\/1403\/26049780\/igx004.5166.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T07:12:06Z","timestamp":1539587526000},"score":7.720508,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/innovateage\/article\/1\/suppl_1\/1403\/3902436"}},"issued":{"date-parts":[[2017,6,30]]},"references-count":0,"journal-issue":{"issue":"suppl_1","published-online":{"date-parts":[[2017,6,30]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/geroni\/igx004.5166","ISSN":["2399-5300"],"issn-type":[{"value":"2399-5300","type":"electronic"}],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2017,6,30]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:49Z","timestamp":1753889809820,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,6,14]]},"abstract":"Background: ReCET utilizing an endoscope administered non-thermal pulsed electric field to stimulate duodenal cellular regeneration may correct abnormal duodenal signaling in type 2 diabetes (T2D). We report updated results from a feasibility study of ReCET therapy in T2D.<\/jats:p>\n Method: This multicenter, open-label, treatment-only study recruited 18-70 yr old; T2D \u226410 years; HbA1c 7.5%-11.0%; BMI 24 - 40 kg\/m2; C-peptide \u2265 333 pmol\/l; and on 1-4 non-insulin glucose-lowering medications (GLMs) which were unchanged post-procedure. Primary endpoint: Device\/procedure-related serious adverse events (SAEs). Secondary endpoints: Changes in metabolic parameters at 24W.<\/jats:p>\n Results: Participants received single energy application (Single Tx, n=12), double energy application (Double Tx, n=18), or the Gen 2 catheter (Gen 2, n=21)- (Figure 1). Procedure success was 100% with no related SAEs. Common AEs were sore throat (25\/51) and transient diarrhea (11\/51), and mostly (76%) mild. Glycemia improved post procedure with trends suggesting an energy-dose response (Figure 1). Mean (SD) HbA1c at 24 wks vs baseline was 7.2 (1.2%) vs. 8.8 (0.9)% (p&lt;0.01) in the Gen 2 group. Gen 2 group follow up is ongoing. Durability of glycemic improvement was observed in Double Tx group at 48 wks.<\/jats:p>\n Conclusions: ReCET therapy is feasible and safe. Glycemic observations support further research.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n D.N. O'Neal: None. A. Sartoretto: Research Support; Endogenex, Erbe Electromedizin GmbH. Advisory Panel; Bariatek. Consultant; Boston Scientific Corporation, Intuitive Surgical. E.I. Ekinci: Advisory Panel; Lilly Diabetes. Research Support; Novo Nordisk, Boehringer-Ingelheim, Eli Lilly and Company. Board Member; Eli Lilly and Company. Advisory Panel; Abbott. Research Support; Endogenex, Versanis, AstraZeneca. G. Manos: None. B. Holt: None. G. Cameron: None. S. Chandran: None. R. Vaughan: None. B.K. Abu Dayyeh: Research Support; USGI Medical, Apollo Endosurgery. Consultant; Boston Scientific Corporation, Medtronic. Other Relationship; Endogenex. Research Support; ERBE.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db24-896-p","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:19:48Z","timestamp":1718349588000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["896-P: Duodenal Mucosal Recellularization via Pulsed Electric Field\u2013Induced Electroporation (ReCET) in Type 2 Diabetes\u2014First-in-Human Experience"],"prefix":"10.2337","volume":"73","author":[{"given":"DAVID N.","family":"O'NEAL","sequence":"first","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ADRIAN","family":"SARTORETTO","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIF I.","family":"EKINCI","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GEORGINA","family":"MANOS","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRONTE","family":"HOLT","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GEORGINA","family":"CAMERON","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUJIEVVAN","family":"CHANDRAN","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RHYS","family":"VAUGHAN","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BARHAM K.","family":"ABU DAYYEH","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/896-P\/156541\/896-P-Duodenal-Mucosal-Recellularization-via","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/896-P\/156541\/896-P-Duodenal-Mucosal-Recellularization-via","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:19:48Z","timestamp":1718349588000},"score":7.720401,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/896-P\/156541\/896-P-Duodenal-Mucosal-Recellularization-via"}},"issued":{"date-parts":[[2024,6,14]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2024,6,14]]}},"URL":"https:\/\/doi.org\/10.2337\/db24-896-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2024,6,14]]},"article-number":"896-P"},{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:47:55Z","timestamp":1778813275156,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2014208"],"award-info":[{"award-number":["GNT2014208"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1175509"],"award-info":[{"award-number":["GNT1175509"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1173874"],"award-info":[{"award-number":["GNT1173874"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012155","name":"Channel 7 Telethon Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024253","name":"Western Australian Future Health and Innovation Fund, Government of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024253","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Although essential for overall health and wellbeing, little is known about skin health in urban\u2010living Australian Aboriginal children. This co\u2010designed, research\u2010service project aimed to describe skin health and document skin disease frequency in urban\u2010living Aboriginal children and young people (CYP, i.e., 0\u201318\u2009years) in Western Australia (WA) and investigate housing associations for skin infections.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Cross\u2010sectional studies were conducted at Aboriginal Community Controlled Health Organizations in Bunbury and Perth, WA, over 2\u2009weeks in September\u2013October 2022. Aboriginal CYP were eligible to participate. Questionnaire responses and examination findings were analyzed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 164 CYP recruited, 149 (91%) were urban\u2010living Aboriginal CYP. Fifty\u2010three percent (78\/148) of caregivers described a dermatological concern in their child; with high caregiver diagnostic accuracy for impetigo (96%), tinea (92%), and atopic dermatitis (AD) (89%). AD (18%, 26\/147), head lice (18%, 27\/147), tinea (12%, 18\/147) and impetigo (7%, 10\/147) were most prevalent. Social housing predicted current head lice (odds ratio [OR] 4.63; 95% confidence interval [CI] 1.72\u201312.50), current tinea (OR 3.15; 95% CI 1.06\u20139.36) and ever impetigo (2.39; 95% CI 1.09\u20135.27). Crowded living conditions predicted ever impetigo (OR 6.28; 95% CI 2.03\u201319.37); whereas frequent bathing (\n p<\/jats:italic>\n value 0.032) and regular swimming in a chlorinated pool (OR 0.12; 95% CI 0.02\u20130.95) were protective.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n We report high caregiver diagnostic accuracy for skin conditions. AD is prevalent, with undertreatment, frequent impetiginization, and sleep disturbance indicating barriers to care. Healthcare providers must advocate for improved housing, as the link between skin infections and socioeconomic disadvantage impacts overall health for urban\u2010living Aboriginal CYP.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pde.70016","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T07:36:44Z","timestamp":1757662604000},"page":"26-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Koolungar<\/i>\n (Children)\n Moorditj<\/i>\n (Strong) Healthy Skin Project Part\n II<\/scp>\n : Skin Health in Urban\u2010Living Australian Aboriginal Children"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5902-040X","authenticated-orcid":false,"given":"Bernadette M.","family":"Ricciardo","sequence":"first","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"},{"name":"Perth Children's Hospital Nedlands Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather\u2010Lynn","family":"Kessaris","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel","family":"Nannup","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Tilbrook","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4261-2094","authenticated-orcid":false,"given":"Jacinta","family":"Walton","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Michie","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad","family":"Farrant","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1789-5570","authenticated-orcid":false,"given":"Ainslie","family":"Poore","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Amgarth\u2010Duff","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Rind","sequence":"additional","affiliation":[{"name":"Derbarl Yerrigan Health Services Aboriginal Corporation East Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richelle","family":"Douglas","sequence":"additional","affiliation":[{"name":"Derbarl Yerrigan Health Services Aboriginal Corporation East Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodie","family":"Ingrey","sequence":"additional","affiliation":[{"name":"South West Aboriginal Medical Service Bunbury Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Thomas","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3899-5250","authenticated-orcid":false,"given":"S. Prasad","family":"Kumarasinghe","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R.","family":"Carapetis","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"},{"name":"Perth Children's Hospital Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asha C.","family":"Bowen","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"},{"name":"Perth Children's Hospital Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136789"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(20)30308-4"},{"key":"e_1_2_11_4_1","volume-title":"Profile of Children and Young People in Western Australia","author":"Commissioner for Children and Young People","year":"2024"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188803"},{"key":"e_1_2_11_6_1","volume-title":"The Western Australian Aboriginal Child Health Survey: The Health of Aboriginal Children and Young People","author":"Zubrick S.","year":"2004"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18643"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15153"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40814\u2010023\u201001428\u20106"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1071\/PY23201"},{"key":"e_1_2_11_11_1","volume-title":"Microdata and TableBuilder: Census of Population and Housing","author":"Australian Bureau of Statistics","year":"2023"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12939\u2010022\u201001738\u2010w"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.14221\/2653\u20103219.1034"},{"key":"e_1_2_11_14_1","unstructured":"Australian Government \u201cAustralian Government Department of Health and Aged Care. Modified Monash Model \u201d(2021) https:\/\/www.health.gov.au\/health\u2010topics\/rural\u2010health\u2010workforce\/classifications\/mmm."},{"key":"e_1_2_11_15_1","unstructured":"K. S.Blake R. L.Kellerson andA.Simic \u201cU.S. Department of Housing and Urban Development \u201d(2007) Measuring Overcrowding in Housing."},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02866\u20102021"},{"key":"e_1_2_11_17_1","unstructured":"Eczema Support Australia \u201cThe Burden of Eczema\u2014Evidence for a National Strategy \u201d(2023) Queensland Australia."},{"key":"e_1_2_11_18_1","volume-title":"National Healthy Skin Guideline: For the Diagnosis, Treatment and Prevention of Skin Infections for Aboriginal and Torres Strait Islander Children and Communities in Australia","author":"The Australian Healthy Skin Consortium","year":"2023"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15122827"},{"key":"e_1_2_11_20_1","unstructured":"Australian Institute of Health and Welfare \u201cHousing Circumstances of First Nations People \u201d(2023) https:\/\/www.aihw.gov.au\/reports\/australias\u2010welfare\/indigenous\u2010housing."},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/09603123.2019.1657074"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20104642(24)00229\u20103"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753\u20106405.12433"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(05)66912\u20107"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754\u20109485.12832"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22968"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27123849"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.13.44"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002167"}],"container-title":["Pediatric Dermatology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.70016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T01:29:54Z","timestamp":1769736594000},"score":7.719959,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70016"}},"issued":{"date-parts":[[2025,9,12]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/pde.70016"],"URL":"https:\/\/doi.org\/10.1111\/pde.70016","archive":["Portico"],"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"published":{"date-parts":[[2025,9,12]]},"assertion":[{"value":"2025-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T08:41:50Z","timestamp":1653813710598},"reference-count":0,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"Supplement 2","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JGO"],"published-print":{"date-parts":[[2018,10,1]]},"abstract":" Background and context: Lung cancer is estimated to be the fifth most commonly diagnosed cancer and leading cause of cancer death in Australia, representing 9.2% of all new cancer cases (n = 138,321) diagnosed and 18.9% of all cancer deaths (n = 48,586). The 5-year survival rate for those with lung cancer is 16%, compared with 68% for all cancers combined (between 2009 and 2013). Lung cancer is also the leading cause of cancer burden in Australia and patients affected by lung cancer may experience high levels of unmet need with associated psychological distress and decreased quality of life. Cancer Australia, Australia's national cancer control agency, developed the national Lung Cancer Framework: Principles for Best Practice Lung Cancer Care (Framework) to provide evidence-based, best practice information, strategies, tools and resources to support local adoption of the 5 principles for best practice management of lung cancer (principles): patient-centered care; multidisciplinary care; timely access to evidence-based care; coordination, communication and continuity of care; and data-driven improvements. Aim: The framework aims to improve the outcomes and experiences of people affected by lung cancer in Australia by supporting national uptake of the principles. Strategy\/Tactics: Cancer Australia: \u2022 established a Lung Cancer Advisory Group to advise on strategies for national implementation of the framework and its principles \u2022 conducted a national lung cancer demonstration project, with advice from an Expert Steering Group, to demonstrate the delivery of lung cancer care according to the principles across a range of service delivery settings, and identify key factors contributing to ongoing delivery of best practice cancer care \u2022 completed systematic reviews for each principle to determine the effectiveness of the principles in improving lung cancer care processes and outcomes. Program\/Policy process: To support national adoption of the framework and its principles, Cancer Australia: \u2022 developed a promotion and communication strategy for widespread national dissemination \u2022 convened a National Summit to bring together policy makers, clinical stakeholders and consumers to support local application of the principles, and drive optimal care for people affected by lung cancer \u2022 identified and communicated consumer, service, and system-level approaches to aid sustainable use of the principles. Outcomes: The evidence-based approach to the development of the framework and its principles identified ways to improve the healthcare system to achieve better outcomes for those affected by lung cancer in Australia. A coordinated approach to the delivery of the National Summit supported those involved in lung cancer care to share and adopt innovative and multilevel strategies for best practice care. What was learned: Embedding strategies to support implementation of the principles, responsive to local context, was key to enabling sustainable improvements in national lung cancer control. <\/jats:p>","DOI":"10.1200\/jgo.18.97500","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T20:13:40Z","timestamp":1538165620000},"page":"243s-243s","update-policy":"http:\/\/dx.doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Improving Outcomes Through Principles of Best Practice Management: Australia's National Lung Cancer Framework"],"prefix":"10.1200","volume":"4","author":[{"given":"B.","family":"Daveson","sequence":"first","affiliation":[{"name":"Cancer Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Milch","sequence":"additional","affiliation":[{"name":"Cancer Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Chynoweth","sequence":"additional","affiliation":[{"name":"Cancer Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Kable","sequence":"additional","affiliation":[{"name":"Cancer Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Austen","sequence":"additional","affiliation":[{"name":"Cancer Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Basrai","sequence":"additional","affiliation":[{"name":"Cancer Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Salvestrin","sequence":"additional","affiliation":[{"name":"Cancer Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Wade","sequence":"additional","affiliation":[{"name":"Independent Health Researcher, Green Point, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Andereisz","sequence":"additional","affiliation":[{"name":"Cancer Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Zorbas","sequence":"additional","affiliation":[{"name":"Cancer Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","container-title":["Journal of Global Oncology"],"language":"en","link":[{"URL":"http:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/jgo.18.97500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T08:29:41Z","timestamp":1653812981000},"score":7.7198668,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/jgo.18.97500"}},"issued":{"date-parts":[[2018,10,1]]},"references-count":0,"journal-issue":{"issue":"Supplement 2","published-print":{"date-parts":[[2018,10,1]]}},"alternative-id":["10.1200\/jgo.18.97500"],"URL":"https:\/\/doi.org\/10.1200\/jgo.18.97500","ISSN":["2378-9506"],"issn-type":[{"value":"2378-9506","type":"electronic"}],"published":{"date-parts":[[2018,10,1]]},"assertion":[{"value":"2018-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication 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system?"],"prefix":"10.1111","volume":"54","author":[{"given":"Brandon","family":"Stretton","sequence":"first","affiliation":[{"name":"SA Health Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua G.","family":"Koovor","sequence":"additional","affiliation":[{"name":"SA Health Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis","family":"Hains","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Kleinig","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8310-0853","authenticated-orcid":false,"given":"Sheryn","family":"Tan","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aashray K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mana","family":"Ittimani","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Dwyer","sequence":"additional","affiliation":[{"name":"SA Health Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"South Australian Health and Medical Research Institute Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"McNeil","sequence":"additional","affiliation":[{"name":"Commission on Excellence and Innovation in Health Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WengOnn","family":"Chan","sequence":"additional","affiliation":[{"name":"SA Health Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Cusack","sequence":"additional","affiliation":[{"name":"SA Health Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick G.","family":"O'Callaghan","sequence":"additional","affiliation":[{"name":"SA Health Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Maddison","sequence":"additional","affiliation":[{"name":"SA Health Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5130-8628","authenticated-orcid":false,"given":"Stephen","family":"Bacchi","sequence":"additional","affiliation":[{"name":"SA Health Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16216"},{"key":"e_1_2_2_3_1","volume-title":"Public Hospitals \u2013 Cycle of Crisis","author":"Australian Medical Association","year":"2021"},{"key":"e_1_2_2_4_1","article-title":"How to solve Australia's health workforce shortage","author":"Chandrasiri S","year":"2023","journal-title":"Insight"},{"key":"e_1_2_2_5_1","volume-title":"China Lockdowns Behind Iodinated Contrast Media Shortage","author":"Australian Medical Association","year":"2022"},{"key":"e_1_2_2_6_1","first-page":"35","article-title":"Assessing technology success and failure using information value chain theory","volume":"263","author":"Coiera E","year":"2019","journal-title":"Stud Health Technol Inform"}],"container-title":["Internal Medicine Journal"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.16308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T03:15:32Z","timestamp":1706152532000},"score":7.717246,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.16308"}},"issued":{"date-parts":[[2024,1]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/imj.16308"],"URL":"https:\/\/doi.org\/10.1111\/imj.16308","archive":["Portico"],"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T11:50:26Z","timestamp":1775908226293,"version":"3.50.1"},"reference-count":0,"publisher":"CSIRO Publishing","issue":"1","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":3337,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2016,6,30]]},"abstract":"The Browse Basin hosts large gas accumulations, some of which are being developed for conventional liquefied natural gas (LNG). Extensive appraisal drilling has been focused in the central Caswell Sub-basin at Ichthys and Prelude, and along the extended Brecknock-Scott Reef Trend; whereas elsewhere the basin remains underexplored. To provide a better understanding of regional hydrocarbon prospectivity, the sequence stratigraphy of the Cretaceous succession and structural framework were analysed to determine the spatial relationship of reservoir and seal pairs, and those areas of enhanced source rock development.<\/jats:p>\n The sequence stratigraphic interpretation is based upon a common North West Shelf stratigraphic framework that has been developed in conjunction with industry, and aligned with the international time scale. Sixty key wells and 2D and 3D seismic data have been interpreted to produce palaeogeographic maps and depositional models for the Cretaceous succession. Geochemical analyses have characterised the molecular and stable isotopic signatures of fluids and correlated them with potential source rocks. The resultant petroleum systems model provides a more detailed understanding of source rock maturity, organic richness and hydrocarbon-generation potential in the basin. The model reveals that many accumulations have a complex charge history, with the mixing of hydrocarbon fluids from multiple Mesozoic source rocks, including the Lower\u2013Middle Jurassic J10\u2013J20 supersequences (Plover Formation), Upper Jurassic\u2013Lowermost Cretaceous J30\u2013K10 supersequences (Vulcan Formation), and Lower Cretaceous K20\u2013K30 supersequences (Echuca Shoals Formation). Burial history and hydrocarbon expulsion models, applied to these Jurassic and Cretaceous supersequences, suggest that numerous petroleum systems are effective within the basin. For example, hydrocarbons are interpreted to have been generated from several source pods within the southern Caswell Sub-basin with migration continuing onto the Yampi Shelf, an area of renewed exploration interest.<\/jats:p>","DOI":"10.1071\/aj15034","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T22:01:48Z","timestamp":1503352908000},"page":"483-494","source":"Crossref","is-referenced-by-count":7,"title":["New insights into the petroleum prospectivity of the Browse Basin: the results of a multi-disciplinary study"],"prefix":"10.1071","volume":"56","author":[{"given":"Nadege","family":"Rollet","sequence":"first","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Grosjean","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne","family":"Edwards","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tehani","family":"Palu","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Abbott","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Totterdell","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Lech","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Khider","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Hall","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Orlov","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duy","family":"Nguyen","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Nicholson","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Higgins","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"McLennan","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2016,6,30]]},"container-title":["The APPEA Journal"],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/56\/1\/483\/850290\/aj15034.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/56\/1\/483\/850290\/aj15034.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T04:02:09Z","timestamp":1766894529000},"score":7.716425,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/ep\/article\/56\/1\/483\/107419\/New-insights-into-the-petroleum-prospectivity-of"}},"issued":{"date-parts":[[2016,6,30]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,6,30]]}},"URL":"https:\/\/doi.org\/10.1071\/aj15034","ISSN":["1326-4966","2206-8996"],"issn-type":[{"value":"1326-4966","type":"print"},{"value":"2206-8996","type":"electronic"}],"published":{"date-parts":[[2016,6,30]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:18Z","timestamp":1753889778606,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"As the prevalence of type 2 diabetes (T2D) escalates, improved models of care (MoC) are necessary to provide the most appropriate care across different geographical locations. Current issues that influence diabetes health include physical, social and psychological factors. This study explores the perspectives of Stakeholders (staff members of community health services) relating to barriers and enablers towards the MoC for individuals with T2D. Semi-structured interviews were conducted with 21 stakeholders working in a semi-rural, low socio-demographic region of Victoria, Australia. Questions were designed to elicit participants\u2019 views on factors that can facilitate or impede access to care, and how best to enhance adoption of an appropriate MoC. Interview transcripts were analysed thematically and categorised using the individual, relationship, community, and societal levels of the socio-ecological model. Stakeholders identified barriers such as living alone and socio-economic constraints, as important to individuals. In terms of relationship factors, many complex influences outside the control of the individual were identified as resulting in diabetes management becoming a non-priority. Transportation issues and lack of culturally sensitive\/safe spaces were also identified as significant barriers for clinic attendance, as were lack of GP understanding of other health professionals\u2019 roles, particularly in a multidisciplinary care setting. Improved diabetes management was identified as an enabler. Stakeholders also perceived implementing an holistic approach to diabetes management as an important enabler for attendance at community centres. This study concludes that stakeholders valued a focus on improving the accessibility of a MoC, by adopting a more integrated approach in a more culturally and physically approachable environment. This may enhance patients\u2019 engagement and the sustainability of care.<\/jats:p>\n \n Disclosure<\/jats:title>\n E.L. Kennedy: None. A. Ng: Consultant; Self; Roche Diabetes Care, Ypsomed AG. B.A. Gordon: None. G. Smith: None. A. Forsyth: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-1208-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:46Z","timestamp":1592238586000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1208-P: Perspectives of Barriers and Enablers from Stakeholders of the Current Model of Care for Diabetes Management in an Australian Regional Area"],"prefix":"10.2337","volume":"69","author":[{"given":"ELIZABETH L.","family":"KENNEDY","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Bundoora, Australia, Bendigo, Australia, Lilydale Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ASHLEY","family":"NG","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Bundoora, Australia, Bendigo, Australia, Lilydale Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRETT A.","family":"GORDON","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Bundoora, Australia, Bendigo, Australia, Lilydale Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GILLIAN","family":"SMITH","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Bundoora, Australia, Bendigo, Australia, Lilydale Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ADRIENNE","family":"FORSYTH","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Bundoora, Australia, Bendigo, Australia, Lilydale Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1208-P\/61027\/1208-P-Perspectives-of-Barriers-and-Enablers-from","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1208-P\/61027\/1208-P-Perspectives-of-Barriers-and-Enablers-from","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:20:55Z","timestamp":1647166855000},"score":7.7162185,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1208-P\/61027\/1208-P-Perspectives-of-Barriers-and-Enablers-from"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-1208-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"1208-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:39:08Z","timestamp":1753889948577,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Glycemic control in the young child with type 1 diabetes (T1D) has traditionally been challenging. Unpredictability in appetite and dietary intake has made the achievement of glycemic targets difficult. This study aimed to assess the nutritional quality and dietary behaviors of young children with T1D that attend a clinic that meets glycemic targets in this age group.<\/jats:p>\n Carers of children aged &lt;7 years with type 1 diabetes attending a specialist Pediatric Diabetes Service in Australia completed a 3 day food diary and a survey regarding diabetes management and dietary behaviours.<\/jats:p>\n Twenty one children participated (mean age: 4.7 \u00b11.3y, 57% male, mean BMI z score: 0.9 \u00b1 0.9, duration since diagnosis 1.6 \u00b11.1y, 38% insulin pump therapy, mean HbA1c: 6.3 \u00b1 0.7% (45\u00b17mmol\/mol)). Offering food \u2019whenever they are hungry\u2019 was associated with higher HbA1c than routine meals (7.2% vs. 6.1%, p=0.02). HbA1c was not correlated with daily total CHO intake, which ranged from 126g to 236g\/day. Almost all carers (95%) gave mealtime insulin before food. Most carers (55%) substituted when 6-10 grams (range 1g to &gt;15g) of CHO less than the predicted quantity was consumed. Children consumed saturated fat in excess of recommendations (15 \u00b1 3% E) with no children meeting recommended serves of vegetables.<\/jats:p>\n Young children with type 1 diabetes can achieve target glycemic control and can safely dose insulin before meals. Continuous eating episodes were positively associated with HbA1c. Dietary quality remains a concern in this age group.<\/jats:p>\n \n Disclosure<\/jats:title>\n R.L. Seckold: None. P. Howley: None. B.R. King: None. K. Bell: Other Relationship; Self; Novo Nordisk Inc.. C.E. Smart: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-1368-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:30Z","timestamp":1529693850000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":2,"title":["Grazing in Young Children with Type 1 Diabetes Is Associated with Higher HbA1c"],"prefix":"10.2337","volume":"67","author":[{"given":"ROWEN L.","family":"SECKOLD","sequence":"first","affiliation":[{"name":"Newcastle, Australia, Callaghan, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER","family":"HOWLEY","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Callaghan, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRUCE R.","family":"KING","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Callaghan, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KIRSTINE","family":"BELL","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Callaghan, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARMEL E.","family":"SMART","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Callaghan, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1368-P\/54046\/Grazing-in-Young-Children-with-Type-1-Diabetes-Is","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1368-P\/54046\/Grazing-in-Young-Children-with-Type-1-Diabetes-Is","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:20:09Z","timestamp":1647163209000},"score":7.715163,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1368-P\/54046\/Grazing-in-Young-Children-with-Type-1-Diabetes-Is"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-1368-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"1368-P"},{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T16:41:33Z","timestamp":1760460093863,"version":"build-2065373602"},"reference-count":13,"publisher":"Australian Society of Exploration Geophysicists","issue":"215","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"published-print":{"date-parts":[[2021,11,2]]},"DOI":"10.1080\/14432471.2021.2012035","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T04:25:24Z","timestamp":1640319924000},"page":"61-63","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Metadata standards for magnetotelluric time-series data"],"prefix":"10.63929","volume":"2021","author":[{"given":"Jingming","family":"Duan","sequence":"first","affiliation":[{"name":"Geoscience Australia, , Canberra, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Kirkby","sequence":"additional","affiliation":[{"name":"Geoscience Australia, , Canberra, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Kyi","sequence":"additional","affiliation":[{"name":"Geoscience Australia, , Canberra, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Geoscience Australia, , Canberra, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Costelloe","sequence":"additional","affiliation":[{"name":"Geoscience Australia, , Canberra, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Hitchman","sequence":"additional","affiliation":[{"name":"Geoscience Australia, , Canberra, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"53371","reference":[{"volume-title":"Data formats, interoperability and sharing. Presentation to EMIW Workshop","year":"2018","author":"Duan J.","key":"CIT0001"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1080\/22020586.2019.12073191"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1029\/2018EO112859"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1080\/14432471.2019.1600210"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1093\/gji\/ggw319"},{"journal-title":"Intrepid Geophysics","year":"2020","author":"Leonard T.","key":"CIT0006"},{"journal-title":"USGS","year":"2018","author":"Peacock J.","key":"CIT0007"},{"journal-title":"IRIS Working Group for Data Handling and Software \u2013 PASSCAL Magnetotelluric Program","year":"2020","author":"Peacock J.","key":"CIT0008"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1080\/22020586.2019.12073015"},{"journal-title":"Scientific Technical Report 15\/08 \u2013 Data","year":"2015","author":"Ritter O.","key":"CIT0010"},{"key":"CIT0011","first-page":"249","author":"Wight D.E.","year":"1988","journal-title":"Expanded Abstracts"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2016.18"},{"journal-title":"Zenodo","year":"2020","author":"Wyborn L.","key":"CIT0013"}],"container-title":["Preview"],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14432471.2021.2012035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T16:09:12Z","timestamp":1760458152000},"score":7.7148876,"resource":{"primary":{"URL":"https:\/\/www.earthdoc.org\/content\/journals\/10.1080\/14432471.2021.2012035"}},"issued":{"date-parts":[[2021,11,2]]},"references-count":13,"journal-issue":{"issue":"215","published-print":{"date-parts":[[2021,11,2]]}},"URL":"https:\/\/doi.org\/10.1080\/14432471.2021.2012035","ISSN":["1443-2471","1836-084X"],"issn-type":[{"type":"print","value":"1443-2471"},{"type":"electronic","value":"1836-084X"}],"published":{"date-parts":[[2021,11,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=texp20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=texp20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-12-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T03:36:32Z","timestamp":1764905792326,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Introduction: Type 2 diabetes is increasingly diagnosed among younger people. Patient engagement with self-care practices is crucial for the optimal management of type 2 diabetes. This study examines the self-care practices of younger and older patients with type 2 diabetes.<\/jats:p>\n Methods: Data were analysed from the Australian National Diabetes Audit (ANDA) that included 2552 adult patients with type 2 diabetes from 56 participating Diabetes Centres. Pre-specified demographic and clinical variables were obtained. Self-care variables (physical activity, following dietary recommendations, medication adherence and monitoring blood glucose levels) were compared in patients \u226464 years and &gt;64 years of age.<\/jats:p>\n Results: Mean age (\u00b1SD) of participants was 63\u00b113 years overall, 53\u00b19 years for the younger group and 73\u00b16 years for the older group. Mean diabetes duration was 9\u00b18 years and 15\u00b110 years for younger and older patients, respectively (p&lt;0.01). A greater proportion of younger patients had HbA1c levels above 7.0% compared with older patients (76% vs. 68%, p&lt;0.001). A greater proportion of younger compared to older patients reported difficulty following dietary recommendations (50% vs. 32%) and forgetting medications (37% vs. 22%) (all p values &lt;0.001). A smaller proportion of younger compared with older patients reported monitoring their blood glucose levels as often as recommended (60%vs. 70%, p&lt;0.001). Younger age was associated with a 2-fold increase in the odds of not following the recommended self-care practices after adjustment for gender, smoking, insulin therapy, depression and allied health attendance (all p values &lt;0.001).<\/jats:p>\n Conclusion: Despite shorter diabetes duration, younger age was associated with worse glycaemic control and poorer diabetes self-care practices among patients with type 2 diabetes. Targeted strategies are urgently required to optimise diabetes self-care practices and thereby improve glycaemic control.<\/jats:p>\n \n Disclosure<\/jats:title>\n N. Nanayakkara: None. A.J. Pease: None. S. Ranasinha: None. N. Wischer: None. B. de Courten: None. S. Zoungas: Advisory Panel; Self; AstraZeneca.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-707-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:35Z","timestamp":1529693855000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["Younger Patients with Type 2 Diabetes Have Poorer Self-Care Practices Compared with Older Patients\u2014Results from the Australian National Diabetes Audit"],"prefix":"10.2337","volume":"67","author":[{"given":"NATALIE","family":"NANAYAKKARA","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Clayton, Australia, Ghin Ghin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTHONY J.","family":"PEASE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Clayton, Australia, Ghin Ghin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SANJEEVA","family":"RANASINHA","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Clayton, Australia, Ghin Ghin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NATALIE","family":"WISCHER","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Clayton, Australia, Ghin Ghin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BARBORA","family":"DE COURTEN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Clayton, Australia, Ghin Ghin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SOPHIA","family":"ZOUNGAS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Clayton, Australia, Ghin Ghin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/707-P\/58282\/Younger-Patients-with-Type-2-Diabetes-Have-Poorer","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/707-P\/58282\/Younger-Patients-with-Type-2-Diabetes-Have-Poorer","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:09:30Z","timestamp":1647166170000},"score":7.714794,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/707-P\/58282\/Younger-Patients-with-Type-2-Diabetes-Have-Poorer"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-707-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"707-P"},{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:08:50Z","timestamp":1758931730067,"version":"3.44.0"},"reference-count":0,"publisher":"BMJ Publishing Group Ltd","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1136\/injuryprev-2016-042156.152","type":"proceedings-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T15:38:01Z","timestamp":1472830681000},"page":"A56.1-A56","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["152\u2005Exercise training to prevent sports injuries: results from a clustered randomised controlled trial"],"prefix":"10.1136","author":[{"given":"Caroline F","family":"Finch","sequence":"first","affiliation":[{"name":"Federation University Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Fortington","sequence":"additional","affiliation":[{"name":"Federation University Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akram","family":"Muhammed","sequence":"additional","affiliation":[{"name":"Federation University Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dara","family":"Twomey","sequence":"additional","affiliation":[{"name":"Federation University Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Doyle","sequence":"additional","affiliation":[{"name":"University of Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Elliott","sequence":"additional","affiliation":[{"name":"University of Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lloyd","sequence":"additional","affiliation":[{"name":"University of Western Australia, Australia"},{"name":"Griffith University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,9,1]]},"event":{"name":"Safety 2016 World Conference, 18\u201321 September 2016, Tampere, Finland"},"container-title":["Sports and Exercise Safety"],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/injuryprev-2016-042156.152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T12:49:56Z","timestamp":1758890996000},"score":7.7146053,"resource":{"primary":{"URL":"https:\/\/injuryprevention.bmj.com\/lookup\/doi\/10.1136\/injuryprev-2016-042156.152"}},"issued":{"date-parts":[[2016,9]]},"references-count":0,"alternative-id":["10.1136\/injuryprev-2016-042156.152"],"URL":"https:\/\/doi.org\/10.1136\/injuryprev-2016-042156.152","published":{"date-parts":[[2016,9]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:19Z","timestamp":1753889839193,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"Early childhood onset of type 1 diabetes (T1D) is associated with poorer cognition. Yet, the contribution of glycemic control to poorer cognition is unclear. We examined the association between glycemic control and full-scale intelligence quotient (FSIQ) in a cohort of children diagnosed with T1D before age 3 followed over 30 years. We recruited children presenting to a tertiary hospital in Australia from 1990-1992 in the prospective Cognition and Longitudinal Assessment of Risk Factors over 30 Years (CLARiFY) cohort study. Those with T1D underwent a cognitive test series at entry and 2, 6, 12 and 30 years post-diagnosis. Linear mixed effects modelling examined associations between HbA1c mean and coefficient of variation and FSIQ over time. Data were available for 12 subjects (6 male). The mean diabetes diagnosis age was 1.9 years. The mean HbA1c at each time of 2, 6, 12 and 30 years was 7.9, 8.3, 8.4 and 8.7%, respectively (Fig.1 shows HbA1c plots across time for each subject). We did not find an association between mean HbA1c (\u03b2=-3.2, p=0.09) nor HbA1c coefficient of variability (\u03b2=23.2, p=0.34) and FSIQ. Future analyses with more data will further document the impact of lifetime glycemic control on IQ and other cognitive measures in later life. Future work will also examine the impact of diagnosis age and acute dysglycemic events on cognitive outcomes 30 years after diagnosis vs healthy controls.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n F.Cameron: None. C.Moran: None. A.Brown: None. R.Beare: None. O.Gbadeyan: None. S.A.Sakowski: None. V.Srikanth: None. E.L.Feldman: None. E.A.Northam: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Institutes of Health (R01DK129320)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-1370-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:56:58Z","timestamp":1687240618000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1370-P: Glycemic Control and Intelligence over 30 Years in Children Diagnosed with Diabetes before 3 Years of Age (CLARiFY Study)"],"prefix":"10.2337","volume":"72","author":[{"given":"FERGUS","family":"CAMERON","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Frankston, Australia, Ann Arbor, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRIS","family":"MORAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Frankston, Australia, Ann Arbor, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AMY","family":"BROWN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Frankston, Australia, Ann Arbor, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"BEARE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Frankston, Australia, Ann Arbor, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OYETUNDE","family":"GBADEYAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Frankston, Australia, Ann Arbor, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STACEY A.","family":"SAKOWSKI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Frankston, Australia, Ann Arbor, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VELANDAI","family":"SRIKANTH","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Frankston, Australia, Ann Arbor, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EVA L.","family":"FELDMAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Frankston, Australia, Ann Arbor, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELISABETH A.","family":"NORTHAM","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Frankston, Australia, Ann Arbor, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1370-P\/150249\/1370-P-Glycemic-Control-and-Intelligence-over-30","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1370-P\/150249\/1370-P-Glycemic-Control-and-Intelligence-over-30","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:56:58Z","timestamp":1687240618000},"score":7.7142963,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1370-P\/150249\/1370-P-Glycemic-Control-and-Intelligence-over-30"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-1370-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"1370-P"},{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:53:41Z","timestamp":1782867221176,"version":"3.54.5"},"publisher-location":"Reston, VA","reference-count":0,"publisher":"American Society of Civil Engineers","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2017,7,6]]},"DOI":"10.1061\/9780784480779.113","type":"proceedings-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T11:01:04Z","timestamp":1499338864000},"page":"913-920","source":"Crossref","is-referenced-by-count":6,"title":["Characterization of Small-Strain Shear Modulus of Sands Subjected to Anisotropic States of Stress"],"prefix":"10.1061","author":[{"given":"Meghdad","family":"Payan","sequence":"first","affiliation":[{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostas","family":"Senetakis","sequence":"additional","affiliation":[{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Khoshghalb","sequence":"additional","affiliation":[{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Khalili","sequence":"additional","affiliation":[{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]},{"name":"UNSW Australia","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30","published-online":{"date-parts":[[2017,7,6]]},"event":{"name":"Sixth Biot Conference on Poromechanics","location":"Paris, France"},"container-title":["Poromechanics VI"],"link":[{"URL":"https:\/\/ascelibrary.org\/doi\/pdf\/10.1061\/9780784480779.113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:10:32Z","timestamp":1782864632000},"score":7.7129664,"resource":{"primary":{"URL":"https:\/\/ascelibrary.org\/doi\/10.1061\/9780784480779.113"}},"issued":{"date-parts":[[2017,7,6]]},"references-count":0,"alternative-id":["10.1061\/9780784480779.113","10.1061\/9780784480779"],"URL":"https:\/\/doi.org\/10.1061\/9780784480779.113","published":{"date-parts":[[2017,7,6]]}},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:40:21Z","timestamp":1651203621106},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"St Vincent's Prostate Cancer Centre"},{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001171","name":"Cancer Institute of NSW","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hillcrest Foundation"},{"name":"National Health & Medical Research Council (NHMRC) project"},{"DOI":"10.13039\/100000892","name":"Prostate Cancer Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000892","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.juro.2011.02.219","type":"journal-article","created":{"date-parts":[[2011,5,19]],"date-time":"2011-05-19T12:36:07Z","timestamp":1305808567000},"source":"Crossref","is-referenced-by-count":0,"title":["151 QUALITY OF LIFE CHANGES FOLLOWING RADICAL PROSTATECTOMY: A PROSPECTIVE COMPARISON OF ROBOTIC & OPEN TECHNIQUES"],"prefix":"10.1097","volume":"185","author":[{"given":"James","family":"Symons","sequence":"first","affiliation":[{"name":"Darlinghurst, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruban","family":"THANIGASALAM","sequence":"additional","affiliation":[{"name":"Darlinghurst, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Savdie","sequence":"additional","affiliation":[{"name":"Darlinghurst, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Smith","sequence":"additional","affiliation":[{"name":"King's Cross, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Egger","sequence":"additional","affiliation":[{"name":"King's Cross, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Pe Benito","sequence":"additional","affiliation":[{"name":"Darlinghurst, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Maree","family":"Haynes","sequence":"additional","affiliation":[{"name":"Darlinghurst, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Siriwardana","sequence":"additional","affiliation":[{"name":"Darlinghurst, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayne","family":"Matthews","sequence":"additional","affiliation":[{"name":"Darlinghurst, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Brenner","sequence":"additional","affiliation":[{"name":"Darlinghurst, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Darlinghurst, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnan","family":"Rasiah","sequence":"additional","affiliation":[{"name":"St. Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Stricker","sequence":"additional","affiliation":[{"name":"Darlinghurst, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534711004678?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534711004678?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2011.02.219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:04:05Z","timestamp":1651201445000},"score":7.7120447,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2011.02.219"}},"issued":{"date-parts":[[2011,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1016\/j.juro.2011.02.219"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2011.02.219","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2011,4]]}},{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:41:52Z","timestamp":1758894112548,"version":"3.44.0"},"reference-count":0,"publisher":"BMJ","issue":"Suppl 1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inj Prev"],"published-print":{"date-parts":[[2012,10]]},"abstract":"\n Background<\/jats:title>\n Poor knowledge of restraint use, and ensuing lower levels of age-appropriate and correct restraint use are common among children whose families speak a language other than English at home in NSW Australia. Behaviour change theories suggest that knowing best practice may not be enough to change behaviour.<\/jats:p>\n <\/jats:sec>\n \n Aims\/Objectives\/Purpose<\/jats:title>\n To identify intervention elements for optimising restraint practices among children from culturally and linguistically diverse (CALD) communities in NSW.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A semi-structured discussion was held in 11 language specific focus groups in Arabic, Assyrian, Cantonese, Mandarin, Vietnamese and Turkish. Pre-existing community groups were used to recruit participants (n=72). Translated transcripts were analysed using the major concepts of the IBCM.<\/jats:p>\n <\/jats:sec>\n \n Results\/Outcome<\/jats:title>\n Restraint use intent among CALD community carers depends how they perceive their child's safety. Child restraint legislation and enforcement appears to increase parental self-efficacy, however concerns over child comfort may negatively influence parental motivation to comply. Large family size, vehicle size and restraint cost are real environmental constraints in some CALD communities. The government is seen as the most credible information source.<\/jats:p>\n <\/jats:sec>\n \n Significance\/Contribution to the Field<\/jats:title>\n Key messages in interventions targeting CALD communities should be the same as those targeting the mainstream, as determinants of restraint use intent are the same regardless of the population. However, for CALD communities there is a specific need to ensure access to detailed information through appropriate delivery strategies and languages. Furthermore, strategies to address practical constraints are particularly important elements for interventions targeting CALD communities.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/injuryprev-2012-040580a.10","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T13:21:21Z","timestamp":1349702481000},"page":"A4.2-A4","source":"Crossref","is-referenced-by-count":0,"title":["USING THE INTEGRATED BEHAVIOUR CHANGE MODEL (IBCM) TO IDENTIFY INTERVENTION ELEMENTS FOR PROMOTING OPTIMAL CHILD RESTRAINT PRACTICES IN NSW"],"prefix":"10.1136","volume":"18","author":[{"given":"J","family":"Brown","sequence":"first","affiliation":[{"name":"Neuroscience Research Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Burton","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Nikolin","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Crooks","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hatfield","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Bilston","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,10,7]]},"container-title":["Injury Prevention"],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/injuryprev-2012-040580a.10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:05:09Z","timestamp":1758891909000},"score":7.7107882,"resource":{"primary":{"URL":"https:\/\/injuryprevention.bmj.com\/lookup\/doi\/10.1136\/injuryprev-2012-040580a.10"}},"issued":{"date-parts":[[2012,10]]},"references-count":0,"journal-issue":{"issue":"Suppl 1","published-online":{"date-parts":[[2012,10,7]]},"published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1136\/injuryprev-2012-040580a.10"],"URL":"https:\/\/doi.org\/10.1136\/injuryprev-2012-040580a.10","ISSN":["1353-8047","1475-5785"],"issn-type":[{"type":"print","value":"1353-8047"},{"type":"electronic","value":"1475-5785"}],"published":{"date-parts":[[2012,10]]}},{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:34:08Z","timestamp":1775018048317,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:00:00Z","timestamp":1693094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian J Rural Health"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1111\/ajr.13031","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:44:30Z","timestamp":1693197870000},"page":"1032-1035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Proposal of the Whyalla Direct Access Tool and pathway for rural Australian colonoscopy services"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3880-3840","authenticated-orcid":false,"given":"Joshua G.","family":"Kovoor","sequence":"first","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Queen Elizabeth Hospital Adelaide South Australia Australia"},{"name":"Port Augusta Hospital Port Augusta South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-4554","authenticated-orcid":false,"given":"Joseph N.","family":"Hewitt","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Queen Elizabeth Hospital Adelaide South Australia Australia"},{"name":"Port Augusta Hospital Port Augusta South Australia Australia"},{"name":"Whyalla Hospital Whyalla South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Barbaro","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Queen Elizabeth Hospital Adelaide South Australia Australia"},{"name":"Whyalla Hospital Whyalla South Australia 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In HFD murine models, systemic IL-22 is efficacious to restore glucose tolerance, reduce circulating triglycerides and hepatic steatosis, and improve AST:ALT ratio, but is also associated with gut and skin toxicity. As an approach to maintain efficacy without skin\/gut adverse effects we have developed a prototype IL-22-based bispecific biologic drug candidate (IL-22-ScFv) which is targeted towards the pancreas and liver. In mouse models of T2D and NAFLD\/NASH twice-weekly subcutaneous administration of IL-22-ScFv provides numerous therapeutic and metabolic benefits. After IL-22-ScFv administration for four weeks in HFD mice random glucose, glucose tolerance and insulin tolerance were normalised (c.f. chow fed controls) . Significant reduction in hepatic steatosis was also seen, evidenced by liver weight, histology, oil-red-O, and (normalisation of) key lipogenic gene expression patterns. In both Thioacetamide\/HFD and Choline Deficient L-Amino acid defined\/HFD mice IL-22-ScFv administration significantly reduced hepatic fibrosis (Masson\u2019s trichrome, picrosirius red, and normalisation of hepatic expression of Col1a1&2, Col3a1, Timp2, Mmp2 and Cd68) . Effective targeting of IL-22 to liver and pancreas was observed with minimal IL-22 exposure to gut and skin. Following four weeks administration of a range of doses of IL-22-ScFv no adverse effects were observed. Histological analysis of gut and skin showed no features of hyperproliferation, consistent with effective targeting of IL-22 to liver and pancreas. Mechanism of action of IL-22-ScFv was again shown to be reduction in cellular stress via IL-22 receptor mediated STAT3 phosphorylation.<\/jats:p>\n In conclusion, liver\/pancreas targeted IL-22 shows promise as a therapeutic approach to metabolic liver disease, with concomitant improvement in disorders of glucose homeostasis.<\/jats:p>\n \n Disclosure<\/jats:title>\n J. B. Prins: None. H. Sajiir: None. S. Keshvari: None. K. Wong: None. J. Lockett: Advisory Panel; Lilly Diabetes. M. Mcguckin: None. S. Z. Hasnain: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db22-119-lb","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T06:24:25Z","timestamp":1653978265000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["119-LB: Targeted IL-22 Improves Glucose Tolerance and Reduces Hepatic Steatosis and Hepatic Fibrosis in Murine Models of Diabetes and Liver Disease"],"prefix":"10.2337","volume":"71","author":[{"given":"JOHN B.","family":"PRINS","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HARESSH","family":"SAJIIR","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SAHAR","family":"KESHVARI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KUAN YAU","family":"WONG","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JACK","family":"LOCKETT","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL","family":"MCGUCKIN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUMAIRA Z.","family":"HASNAIN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/119-LB\/146772\/119-LB-Targeted-IL-22-Improves-Glucose-Tolerance","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/119-LB\/146772\/119-LB-Targeted-IL-22-Improves-Glucose-Tolerance","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T06:24:28Z","timestamp":1653978268000},"score":7.7083654,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/119-LB\/146772\/119-LB-Targeted-IL-22-Improves-Glucose-Tolerance"}},"issued":{"date-parts":[[2022,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db22-119-lb","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2022,6,1]]},"article-number":"119-LB"},{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:08:21Z","timestamp":1785859701053,"version":"3.56.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian J Rural Health"],"published-print":{"date-parts":[[2023,10]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Stroke in Regional Australia may have worse outcomes due to difficulties accessing optimal care. The South Australian Regional Telestroke service aimed to improve telestroke neurologist access, supported by improved ambulance triage.<\/jats:p><\/jats:sec>Objective<\/jats:title>To assess stroke care quality and patient mortality pre\u2010 and postimplementation of a vascular neurologist\u2010led Telestroke service.<\/jats:p><\/jats:sec>Design<\/jats:title>Historically controlled mixed methods cohort study comparing key quality indicators and patient mortality (6\u2009months pre\u2010 vs. 18\u2009months postimplementation date [4 June 2018]) at the three major South Australian regional stroke centres. The primary outcome was 13 care quality indicators as a combined composite risk\u2010adjusted score, and the secondary outcome was risk\u2010adjusted mortality at 12\u2010month postadmission.<\/jats:p><\/jats:sec>Findings<\/jats:title>On an annualised basis, of 189 patients with stroke, more were admitted postintervention to the regional stroke centres than in the control period (158 [annualised rate 105.3, 95% CI 86.2\u2013127.4] vs. 31 [annualised rate 62.0, 95% CI 47.5\u201379.5]) Baseline patient characteristics were similar in both periods. Post\u2010implementation, median last\u2010known\u2010well time to presentation (3.5\u2009h [IQR 1.6\u201317] vs. 2.0 [IQR 1\u201314]; p<\/jats:italic>\u2009=\u20090.46) and door to needle times (121\u2009min [IQR 97\u2013144] vs. 90 [IQR 75\u2013138]; p<\/jats:italic>\u2009=\u20090.65) were not significantly lower but an improvement in the combined composite quality score was observed (0.069 [95% CI 0.004\u20130.134; p<\/jats:italic>\u2009=\u20090.04]), reflecting individual improvements in some quality indicators. Mortality at 12\u2010month postimplementation was substantially lower postimplementation (prechange 23% vs. postchange 13% [hazard ratio 0.58 (95% CI 0.44\u20130.76; p<\/jats:italic>\u2009<\u20090.001)]).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Implementation of a South Australian Regional Telestroke service was associated with improved care metrics and lower mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajr.13012","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:39:23Z","timestamp":1687653563000},"page":"878-885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Implementation of the South Australian Regional Telestroke service is associated with improved care quality and lower stroke mortality: A retrospective cohort study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1645-2258","authenticated-orcid":false,"given":"Rudy","family":"Goh","sequence":"first","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Lyell McEwin Hospital Elizabeth Vale South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Hillier","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thu\u2010Lan","family":"Kelly","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthea","family":"Worley","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Dixon","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Kurunawai","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Tan","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Mahadevan","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Willcourt","sequence":"additional","affiliation":[{"name":"Flinders Medical Centre Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Jannes","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4430-3276","authenticated-orcid":false,"given":"Timothy","family":"Kleinig","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,23]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"No Post Code Untouched [Internet].Stroke Foundation \u2013 Australia. [cited 2022 Feb 27]. Available from:https:\/\/strokefoundation.org.au\/What\u2010we\u2010do\/Research\/No%20Postcode%20Untouched"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000202588.95876.a7"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50570"},{"key":"e_1_2_12_5_1","unstructured":"DixonK KleinigT JannesJ.Improving Outcomes for Rural Stroke Patients: A South Australian Success Story.2019[cited 2022 Aug 14]. Available from:http:\/\/www.ruralhealth.org.au\/15nrhc\/sites\/default\/files\/E2\u20101_Dixon.pdf"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70201-5"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.023075"},{"key":"e_1_2_12_8_1","unstructured":"Stroke Foundation.National Stroke Audit Acute Services Report 2021 [Internet].2021[cited 2022 Aug 14]. Available from:https:\/\/informme.org.au\/media\/0bzk42xf\/2021_acute\u2010services\u2010national\u2010report.pdf"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.02.019"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-0361.2010.00352.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14544-8"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CA.S7094"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.08.015"}],"container-title":["Australian Journal of Rural Health"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajr.13012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T18:02:08Z","timestamp":1704391328000},"score":7.708225,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajr.13012"}},"issued":{"date-parts":[[2023,6,23]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/ajr.13012"],"URL":"https:\/\/doi.org\/10.1111\/ajr.13012","archive":["Portico"],"ISSN":["1038-5282","1440-1584"],"issn-type":[{"value":"1038-5282","type":"print"},{"value":"1440-1584","type":"electronic"}],"published":{"date-parts":[[2023,6,23]]},"assertion":[{"value":"2023-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T14:10:54Z","timestamp":1759932654189,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"S22","license":[{"start":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T00:00:00Z","timestamp":1703462400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2023,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Increased amount of physical activity has been associated with reduced incidence of dementia. It is less clear whether the discrete physical performance measures of balance and strength are associated with dementia incidence. We investigated whether baseline measures of balance and strength were associated with incident dementia.<\/jats:p><\/jats:sec>Method<\/jats:title>A cohort of 1,314 men with no recorded history of dementia, aged 79\u201097 underwent physical performance assessments between 2011 and 2013. These assessments were performed during wave 4 of the Health in Men Study, initially recruiting participants 1996\u20109 in Perth, Australia. Balance was assessed with a modified Balance Outcome Measure for Elder Rehabilitation (mBOOMER) score: a combination of three tests, the Timed Up and Go, Step and Functional Reach Tests. Strength was tested using knee extension with a spring dynamometer, measured in kilograms. Incident dementia was identified up to December 2017 from the Western Australian Data Linkage System and the national Aged Care Assessment Program. Data were analysed using Cox proportional hazards models. Balance and strength measures were entered as restricted cubic splines to allow for non\u2010linear relationships. Models were adjusted for sociodemographic, lifestyle and health variables, including hours of physical activity.<\/jats:p><\/jats:sec>Result<\/jats:title>A total of 187 (14.2%) incident cases of dementia were identified. Higher (better) mBOOMER scores were associated with decreased risk of incident dementia, with greater changes in risk occurring at higher scores (1 vs 0: HR 0.91, 95% CI 0.81\u20101.01, 6 vs 5: HR 0.91, 95% CI 0.81\u20101.01, 9 vs 8: HR 0.77, 95% CI 0.70\u20100.84, 12 vs 11: HR 0.51, 95% CI 0.37\u20100.69). Higher knee extension strength was associated with a decreased risk of incident dementia, with greater changes occurring at lower levels then plateauing at around 25 kilograms (5kg vs 4kg: HR 0.93, 95% CI 0.89\u20100.97, 15kg vs 14kg: HR 0.93, 95% CI 0.89\u20100.97, 25kg vs 24kg: HR 0.99, 95% CI 0.95\u20101.02, 35kg to 34kg: HR 1.00, 95% CI 0.95\u20101.06). Relationships remained after excluding those with a dementia diagnosis within two years of baseline physical performance assessment.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Better balance and strength are both associated with decreased risk of developing dementia, thus representing potentially modifiable risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.077415","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T10:04:59Z","timestamp":1703498699000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations between balance, strength and incident dementia in older men: the Health in Men Study"],"prefix":"10.1002","volume":"19","author":[{"given":"Michelle L","family":"Trevenen","sequence":"first","affiliation":[{"name":"University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Paterson","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Hill","sequence":"additional","affiliation":[{"name":"Monash University, Melbourne, VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo P","family":"Almeida","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bu","family":"Yeap","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Golledge","sequence":"additional","affiliation":[{"name":"James Cook University, Townsville, QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme","family":"Hankey","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Flicker","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,25]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.077415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T13:30:54Z","timestamp":1759930254000},"score":7.7080684,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.077415"}},"issued":{"date-parts":[[2023,12]]},"references-count":0,"journal-issue":{"issue":"S22","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/alz.077415"],"URL":"https:\/\/doi.org\/10.1002\/alz.077415","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"type":"print","value":"1552-5260"},{"type":"electronic","value":"1552-5279"}],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-12-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e077415"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:41:21Z","timestamp":1753890081044,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Background and Aims: Elevated maternal triglycerides (TG) have been associated with adverse pregnancy outcomes including an increased risk of preeclampsia and macrosomia. Maternal TG are primarily measured in the fasting state and at single time points during pregnancy. Temporal and prandial changes in TG levels during pregnancy are not well described. The purpose of this study was to examine flux of capillary glucose and TG in late pregnancy, how they are influenced by high and low fat meals, and whether they relate to infant body composition.<\/jats:p>\n Materials and Methods: Women in the third trimester of pregnancy completed 4 days of home capillary glucose and TG monitoring (4 times a day (fasting and two hours post each meal)). Using the Roche Accutrend Plus meter. Each woman consumed an isocaloric high fat (41%) and a low fat (25%) breakfast meal on different days during the study period. Area under the curve (AUC) for the capillary glucose and TG measures after the standardized meals was calculated using trapezoidal approximation. AUC for women with and without GDM was compared for each meal and metabolic measure. Infant body fat % was measured by air displacement plethysmography.<\/jats:p>\n Results: To date, thirteen women, 7 with GDM and 6 normoglycaemic have completed the study. Median capillary glucose levels: fasting 5.0 (95% CI 4.6-5.2) mmol\/L and postprandial 6.0 (95% CI 5.7-6.2) mmol\/L. Median capillary TG: fasting 3.3 (95% CI 2.9-3.8) mmol\/L and postprandial 3.6 (95% CI 3.2-3.8) mmol\/L. Mean infant body fat % 10.6 (SD4.9)%. There were no significant differences in capillary glucose or triglycerides between the meals although capillary glucose trended higher with the low fat meal. GDM status did not affect the AUC glucose or AUC triglycerides for either meal.<\/jats:p>\n Conclusion: This study demonstrates that capillary triglycerides can be monitored at home in a similar fashion to capillary glucose. Capillary triglyceride levels were not related to infant anthropometry and did not vary significantly with meal fat content. Recruitment is ongoing.<\/jats:p>\n \n Disclosure<\/jats:title>\n H.L. Barrett: None. M. Dekker: Speaker's Bureau; Self; Abbott. Other Relationship; Self; Nestl\u00e9. S.J. de Jersey: None. M.C. d'Emden: Advisory Panel; Self; AstraZeneca. Speaker's Bureau; Self; AstraZeneca. Advisory Panel; Self; Eli Lilly and Company. Speaker's Bureau; Self; Eli Lilly and Company, Boehringer Ingelheim GmbH. Advisory Panel; Self; Sanofi. Speaker's Bureau; Self; Sanofi, Novo Nordisk A\/S, Novartis Pharmaceuticals Corporation. L. Callaway: None. H. McIntyre: Speaker's Bureau; Self; Novo Nordisk Inc.. Research Support; Self; Danish Diabetes Academy.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-1422-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:30Z","timestamp":1529693850000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Postprandial Triglycerides in the Home Setting"],"prefix":"10.2337","volume":"67","author":[{"given":"HELEN L.","family":"BARRETT","sequence":"first","affiliation":[{"name":"South Brisbane, Australia, St. Lucia, Australia, Brisbane, Australia, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARLOES NITERT","family":"DEKKER","sequence":"additional","affiliation":[{"name":"South Brisbane, Australia, St. Lucia, Australia, Brisbane, Australia, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUSAN J.","family":"DE JERSEY","sequence":"additional","affiliation":[{"name":"South Brisbane, Australia, St. Lucia, Australia, Brisbane, Australia, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL C.","family":"D'EMDEN","sequence":"additional","affiliation":[{"name":"South Brisbane, Australia, St. Lucia, Australia, Brisbane, Australia, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEONIE","family":"CALLAWAY","sequence":"additional","affiliation":[{"name":"South Brisbane, Australia, St. Lucia, Australia, Brisbane, Australia, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"DAVID MCINTYRE","sequence":"additional","affiliation":[{"name":"South Brisbane, Australia, St. Lucia, Australia, Brisbane, Australia, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1422-P\/54342\/Maternal-Postprandial-Triglycerides-in-the-Home","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1422-P\/54342\/Maternal-Postprandial-Triglycerides-in-the-Home","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:23:01Z","timestamp":1647163381000},"score":7.7078934,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1422-P\/54342\/Maternal-Postprandial-Triglycerides-in-the-Home"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-1422-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"1422-P"},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:41:32Z","timestamp":1651203692505},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.juro.2012.02.1992","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T04:19:51Z","timestamp":1333513191000},"source":"Crossref","is-referenced-by-count":0,"title":["1471 QUALITY OF LIFE OUTCOMES AMONGST MEN UNDERGOING CONTEMPORARY TECHNIQUES FOR THE TREATMENT OF LOCALISED PROSTATE CANCER: A PROSPECTIVE STUDY"],"prefix":"10.1097","volume":"187","author":[{"given":"Samarth","family":"Chopra","sequence":"first","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruban","family":"Thanigasalam","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieran","family":"Beattie","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Egger","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Smith","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Symons","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Maree","family":"Haynes","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Savdie","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Brenner","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishan","family":"Rasiah","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Stricker","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534712023543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534712023543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2012.02.1992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:08:33Z","timestamp":1651201713000},"score":7.707678,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2012.02.1992"}},"issued":{"date-parts":[[2012,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1016\/j.juro.2012.02.1992"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2012.02.1992","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2012,4]]}},{"indexed":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T04:16:27Z","timestamp":1686370587578},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"7_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,4,4]]},"abstract":"Abstract<\/jats:title>\n Introduction The complex spatial cellular interactions of immune cell populations within the melanoma TIME are associated with patient prognosis and immunotherapy response. Novel multiplex immunofluorescence (mIHC) and spatial analysis techniques enable comprehensive investigation of these interactions. This study aimed to develop an automated spatial analysis workflow for large patient cohorts and to determine immunospatial patterns associated with outcome in patients (pts) with primary melanoma as well as pts with stage III melanoma treated with adjuvant immunotherapy.<\/jats:p>\n Methods Two cohorts with available clinical & mIHC data were studied: one of primary melanoma pts (primary cohort, n=46), and another of baseline resected stage III melanoma pts who received adjuvant anti-PD-1 (stage III cohort, n=119). Melanoma tissue was stained for CD8+ T cells and the markers CD103, PD-1 and CD39 in both cohorts and the primary cohort was additionally stained for NK cells, B cells, and Langerhans cells (LCs). mIHC data was investigated using the SPIAT spatial analysis R package. Immune-melanoma and immune-immune spatial relationships were quantified throughout the entire tissue and analysed using neighborhood analysis and cell colocalization metrics including entropy and mixing interaction scores.<\/jats:p>\n Results In the primary melanoma cohort, 11 neighborhood metaclusters (NMCs) were identified from 1617 neighborhoods. NMCs with high B cells, CD39+CD103+ CD8+ T cells, or LCs were associated with improved outcomes in this cohort. Neighborhood composition varied significantly based on tissue localisation, with B cells, LCs and NK cells significantly increased in marginal and stromal neighborhoods (p&lt;0.0001). Over 100 B cell aggregate (BCA) neighborhoods were identified predominantly at the tumor margins and adjacent stroma. These BCAs were likely early TLSs based on their localisation and immune composition. BCA composition was further compared based on patient outcomes, with those harboring increased CD103-PD-1+ CD8+ T cells associated with poor outcome. In-depth pairwise analysis of immune phenotypes with melanoma cells found that increased B cell-melanoma and CD103+PD-1- CD8+ T cell-melanoma interaction was associated with improved outcomes in the primary cohort. In the stage III cohort, increased intratumoral immune diversity was associated with reduced melanoma recurrence (p=0.0004).<\/jats:p>\n Conclusions In developing a cohort-wide TIME spatial analytic approach and workflow, we identified multiple immunospatial associations with patient outcome in primary and stage III metastatic melanoma. Intratumoral immune diversity and immune cell neighborhoods indicate beneficial anti-tumor immune functions contributing towards improved patient outcomes.<\/jats:p>\n Citation Format: Grace Heloise Attrill, Eva R. Shteinman, Xinyu Bai, Felix Marsh-Wakefield, Camelia Quek, Umaimainthan Palendira, Ismael A. Vergara, Georgina V. Long, Richard A. Scolyer, James S. Wilmott. Spatial organization of the tumour immune microenvironment (TIME) in primary and metastatic melanoma is associated with patient outcome [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2369.<\/jats:p>","DOI":"10.1158\/1538-7445.am2023-2369","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T02:28:05Z","timestamp":1680661685000},"page":"2369-2369","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 2369: Spatial organization of the tumour immune microenvironment (TIME) in primary and metastatic melanoma is associated with patient outcome"],"prefix":"10.1158","volume":"83","author":[{"given":"Grace Heloise","family":"Attrill","sequence":"first","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva R.","family":"Shteinman","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Bai","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Marsh-Wakefield","sequence":"additional","affiliation":[{"name":"2University of Sydney, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camelia","family":"Quek","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umaimainthan","family":"Palendira","sequence":"additional","affiliation":[{"name":"2University of Sydney, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismael A.","family":"Vergara","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina V.","family":"Long","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Scolyer","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Wilmott","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/83\/7_Supplement\/2369\/723368\/Abstract-2369-Spatial-organization-of-the-tumour","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/83\/7_Supplement\/2369\/723368\/Abstract-2369-Spatial-organization-of-the-tumour","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T18:10:46Z","timestamp":1686334246000},"score":7.7058144,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/83\/7_Supplement\/2369\/723368\/Abstract-2369-Spatial-organization-of-the-tumour"}},"issued":{"date-parts":[[2023,4,4]]},"references-count":0,"journal-issue":{"issue":"7_Supplement","published-print":{"date-parts":[[2023,4,4]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2023-2369","ISSN":["1538-7445"],"issn-type":[{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2023,4,4]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:38:29Z","timestamp":1753889909494,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"Background: Gestational diabetes mellitus (GDM) diagnosis is resource intensive and controversial. A modified COVID-19 GDM diagnostic method was introduced at Western Health Melbourne, an Australian tertiary hospital caring for a multi-ethnic population with a high GDM prevalence at 20-23%. In place of a universal 2 hour 75g OGTT, a novel two step diagnostic method was instituted. A fasting blood glucose (FBG) was performed with thresholds based on a secondary analysis of HAPO data. A FBG of \u22655.1mmol\/L (91.8mg\/dL) diagnosed GDM; women with FBG 4.7-5.0mmol\/L (84.6-90.0mg\/dL) proceeded to an OGTT (IADPSG diagnostic criteria); FBG \u22644.6mmol\/L (82.8mg\/dL) was considered to exclude GDM.<\/jats:p>\n Methods: A retrospective cohort study of singleton pregnancies birthing after 20 weeks\u2019 gestation compared perinatal outcomes in 6469 women who underwent modified screening (MS) during the COVID-19 pandemic with 8669 women who had conventional screening (CS) prior to COVID-19.<\/jats:p>\n Results: GDM prevalence was the same using either MS or CS (22.9 vs 22.2% p=0.31) with similar rates of insulin use. There was no difference in the prevalence of large for gestational age infants (10.3 vs 9.4% p=0.06), pre-term birth (6.6 vs 6.4% p=0.53) or gestational age at birth (39.2 vs 39.1 weeks). Mean birth weight was increased with MS (3335g vs 3307g) and small for gestational age rate reduced (9.1 vs 10.5% p=0.01). The MS group had fewer inductions (34.2 vs 39.8% p&lt;0.01). Primary caesarean section rate was unchanged (18.4 vs 18.4% p=0.91). MS reduced the need for an OGTT by 76%. Women with a FBG \u22644.6mmol\/L by MS had non-inferior outcomes compared to women with a FBG \u22644.6mmol\/L with CS irrespective of GDM diagnosis.<\/jats:p>\n Conclusion: In a large multi-ethnic cohort with a high prevalence of GDM, modified screening using FBG greatly reduced the number of resource intensive OGTTs with non-inferior perinatal outcomes. A prospective randomised trial comparing these methods is warranted.<\/jats:p>\n \n Disclosure<\/jats:title>\n J. Deitch: None. J. M. Said: None. G. R. Teale: None. D. Kevat: Advisory Panel; Novo Nordisk, Speaker's Bureau; Boehringer Ingelheim and Eli Lilly Alliance, Novo Nordisk, Abbott Diabetes, AstraZeneca. I. Lee: None. C. J. Yates: None. E. Kathpal: None. P. Lawton: None. I. Shahid: None. C. Steele: None. P. S. Hamblin: None. B. Krishnamurthy: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Australian Government Research Training Program; Sheppard Millar Lowe Research Trust Scholarship<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-179-lb","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:35:19Z","timestamp":1687242919000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["179-LB: Should We Screen with a Fasting Blood Glucose Test? A Novel Two-Step Screening Strategy for Gestational Diabetes\u2014A Large Tertiary Comparative Cohort Study"],"prefix":"10.2337","volume":"72","author":[{"given":"JESSICA","family":"DEITCH","sequence":"first","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I-LYNN","family":"LEE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTOPHER J.","family":"YATES","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ESHA","family":"KATHPAL","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL","family":"LAWTON","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IBRAHIM","family":"SHAHID","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHERYL","family":"STEELE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER S.","family":"HAMBLIN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BALASUBRAMANIAN","family":"KRISHNAMURTHY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOANNE M.","family":"SAID","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GLYN R.","family":"TEALE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DEV","family":"KEVAT","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/179-LB\/150905\/179-LB-Should-We-Screen-with-a-Fasting-Blood","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/179-LB\/150905\/179-LB-Should-We-Screen-with-a-Fasting-Blood","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:35:19Z","timestamp":1687242919000},"score":7.705445,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/179-LB\/150905\/179-LB-Should-We-Screen-with-a-Fasting-Blood"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-179-lb","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"179-LB"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:41:33Z","timestamp":1753890093828,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Background: Continuous Glucose Monitoring (CGM) technology has improved glycemia in people with diabetes. However, user burden including frequent calibration, and reinsertion of short-term devices limits adoption of this technology.<\/jats:p>\n Aim: Our objective was to retrospectively analyze CGM data from a fully implanted prototype sensor to assess feasibility of an extended calibration interval.<\/jats:p>\n Methods: The Eclipse\u00ae ICGM\u00ae System was surgically inserted in the lower abdomen, superficial to the rectus muscle sheath (Figure 1) in 6 adults with T1 diabetes, Mean (SD) age 42(12) years; 33% Females, HbA1c 7.1% (1.2)%\/54(13) mmol\/mol. For 6 months participants self-monitored blood glucose 4 times\/day and wore a Dexcom G5 CGM. In addition, monthly clinic visits include meal-tests with frequent sampling YSI plasma glucose for paired analyses. Analyses of investigational device CGM data was retrospective against benchmark measurements.<\/jats:p>\n Results: There were no device associated adverse events. Data from three participants demonstrate intervals of 30, 48 and 85 days between calibrations without impacting overall performance. Preliminary measures show clinically relevant accuracy of &gt;95 % within the A+B ranges.<\/jats:p>\n Conclusion: Interim data supports extended interval calibration for the fully implanted prototype Eclipse\u00ae ICGM\u00ae System which holds promise of CGM with fewer device interactions and enhanced patient experience.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n P. Gupta: Employee; Self; GlySens Incorporated. A. Butler: Employee; Self; GlySens Incorporated. K. Bertsch: None. H. Jones: None. M.H. Lee: Research Support; Self; Medtronic. Speaker\u2019s Bureau; Self; AstraZeneca, Medtronic. V.R. Obeyesekere: None. S.L. Martha: None. A. Jenkins: Advisory Panel; Self; Abbott, Medtronic. Research Support; Self; Abbott, GlySens Incorporated, Medtronic, Sanofi-Aventis. D.N. ONeal: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-2182-pub","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:49Z","timestamp":1592238589000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["2182-PUB: Feasibility of Extended Calibration Intervals with a Long-Term, Implantable CGM System"],"prefix":"10.2337","volume":"69","author":[{"given":"PIYUSH","family":"GUPTA","sequence":"first","affiliation":[{"name":"San Diego, CA, Melbourne, Australia, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTHONY","family":"BUTLER","sequence":"additional","affiliation":[{"name":"San Diego, CA, Melbourne, Australia, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KRISTA","family":"BERTSCH","sequence":"additional","affiliation":[{"name":"San Diego, CA, Melbourne, Australia, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HANNAH","family":"JONES","sequence":"additional","affiliation":[{"name":"San Diego, CA, Melbourne, Australia, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MELISSA H.","family":"LEE","sequence":"additional","affiliation":[{"name":"San Diego, CA, Melbourne, Australia, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VARUNI R.","family":"OBEYESEKERE","sequence":"additional","affiliation":[{"name":"San Diego, CA, Melbourne, Australia, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SANDRA L.","family":"MARTHA","sequence":"additional","affiliation":[{"name":"San Diego, CA, Melbourne, Australia, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"San Diego, CA, Melbourne, Australia, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"ONEAL","sequence":"additional","affiliation":[{"name":"San Diego, CA, Melbourne, Australia, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/2182-PUB\/56020\/2182-PUB-Feasibility-of-Extended-Calibration","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/2182-PUB\/56020\/2182-PUB-Feasibility-of-Extended-Calibration","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:26:13Z","timestamp":1647163573000},"score":7.7054014,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/2182-PUB\/56020\/2182-PUB-Feasibility-of-Extended-Calibration"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-2182-pub","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"2182-PUB"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:39:12Z","timestamp":1753889952989,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Objectives: Samoan people are susceptible to early onset of type 2 diabetes and have low primary care participation. We have evaluated the effectiveness of a culturally adapted, church-based intervention delivered by Samoan coaches and Peer Support Facilitators to prevent and manage type 2 diabetes in Samoans associated with 3 churches in South Western Sydney (SWS).<\/jats:p>\n Methods: This pre-post study included Samoans \u226518 years and involved the delivery of 12 lifestyle messages and 10 diabetes messages. Participants completed questionnaires, the diabetes knowledge and behavior questionnaire, anthropometric measurements and provided a non-fasting blood sample (\u2018new\u2019 diabetes diagnosis was defined if HbA1c or random blood glucose was \u22656.5% (48 mmol\/mol) or \u226511.1mmol\/l respectively). Obesity was defined using a Pacific body mass index (BMI) threshold \u226532kg\/m2.<\/jats:p>\n Results: One hundred participants (70%) participated with 68 (mean age 49.6\u00b114.2 years; female 57.4%) completing data collection 3-8 months after commencing the intervention. The prevalence of obesity was 73% and diabetes was 32.8% (19.8% previously diagnosed; 13% undiagnosed). Overall, HbA1c fell from baseline to follow-up (mean\u00b1SD; 6.4\u00b11.7% (46 mmol\/mol) vs. 6.0\u00b11.4% (42 mmol\/mol); p&lt;0.001). HbA1c reductions were greatest in participants with known diabetes (8.1\u00b12.4% (65 mmol\/mol) vs. 7.4\u00b11.8% (57 mmol\/mol); p=0.040). The number of participants engaging in moderate and vigorous activities per week increased significantly (336.7\u00b1136.3mins vs. 622.6\u00b1213.0 mins; p=0.019). Diabetes knowledge increased from baseline to follow-up (45.5\u00b115.7% to 60.3\u00b120.1%; p&lt;0.001). There were no significant reductions in weight, blood pressure or waist circumference at follow-up.<\/jats:p>\n Conclusion: There is a high prevalence of diabetes and its risk factors among Samoans living in SWS. A structured church-based culturally tailored lifestyle intervention showed promise in reducing their diabetes risks.<\/jats:p>\n \n Disclosure<\/jats:title>\n D. Ndwiga: None. F. MacMillan: None. K. McBride: None. O. Alofivae-Doorbinnia: None. J. Reath: None. P.A. Abbott: None. D. Simmons: Speaker's Bureau; Self; Sanofi-Aventis. Other Relationship; Self; Medtronic.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n South Western Sydney Local Health District; South Western Sydney Primary Health Network; WentWest Health Care; Western Sydney University<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-1661-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T01:29:07Z","timestamp":1559698147000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["1661-P: Outcomes of a Church-Based Lifestyle Intervention among Australian Samoans Living in South Western Sydney (SWS)\u2014A Pilot Study"],"prefix":"10.2337","volume":"68","author":[{"given":"DOROTHY","family":"NDWIGA","sequence":"first","affiliation":[{"name":"Sydney, Australia, Campbelltown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FREYA","family":"MACMILLAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Campbelltown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATE","family":"MCBRIDE","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Campbelltown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OLATAGA","family":"ALOFIVAE-DOORBINNIA","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Campbelltown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENNIFER","family":"REATH","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Campbelltown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PENELOPE A.","family":"ABBOTT","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Campbelltown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"SIMMONS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Campbelltown, 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Standard treatment approaches, including craniospinal irradiation (CSI), can result in severe lifelong side effects and have not changed for decades resulting in a stagnation of survival outcomes for children with aggressive medulloblastoma. Despite successes in other cancers, no immunotherapies have been approved for use in paediatric medulloblastoma. Unlike other solid tumours, medulloblastomas are myeloid dominant, and immunotherapies must be rationally designed with the tumour microenvironment in mind. Anti-CD47 antibody therapy activates macrophages against cancer cells by blocking anti-phagocytic signalling mediated by CD47-SIRPa ligation and has shown preclinical efficacy in brain cancer models. We have developed preclinical CSI protocols that mimic clinical treatment response using a small animal radiotherapy platform. We show that CSI depletes adaptive immune cells in the brain, increasing the proportional abundance of myeloid cells, suggesting an opportunity to combine radiation with myeloid-targeted immunotherapy. We show that anti-CD47 therapy is ineffective as a single agent against a patient-derived xenograft model of Group 3 medulloblastoma (SJ_MB002), and that while the CSI protocol causes temporary tumour regression, the combination of anti-CD47 with CSI results in marked and persistent tumour regression. To enhance our preclinical evaluation of CSI and anti-CD47, we have developed new mouse models that more accurately reflect the developing microenvironment of children and show that immune populations in paediatric brain are distinct from adult mouse brain. Future work will elucidate the mechanisms by which radiotherapy alters the medulloblastoma microenvironment to enhance the anti-tumour activity of myeloid immune cells in the brain. By evaluating this novel combination of immunotherapy with standard medulloblastoma treatments, in age-appropriate models, our research should facilitate the rational selection and rapid translation of optimised treatment combinations for future medulloblastoma clinical trials.<\/jats:p>","DOI":"10.1093\/neuonc\/noac079.641","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T11:49:40Z","timestamp":1654256980000},"page":"i172-i173","source":"Crossref","is-referenced-by-count":0,"title":["MODL-18. 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Social Care Comm"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1111\/hsc.13978","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T07:39:39Z","timestamp":1661499579000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rural health workers' perspectives and experience with an online educational program in behavioural activation: A thematic analysis"],"prefix":"10.1155","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0818-1312","authenticated-orcid":false,"given":"Kuda","family":"Muyambi","sequence":"first","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun","family":"Dennis","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"},{"name":"Flinders & Upper North Local Health Network 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Gunn","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kat","family":"Kenyon","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Jones","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"},{"name":"La Trobe University Bundoora Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Australian Psychology Society. (2019).The APS response to the productivity commission inquiry into mental health.https:\/\/www.pc.gov.au\/__data\/assets\/pdf_file\/0003\/243390\/sub543\u2010mental\u2010health.pdf"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14780887.2019.1670765"},{"issue":"9","key":"e_1_2_12_4_1","first-page":"129","article-title":"Effects of the flipped classroom model on Students' self\u2010directed learning readiness and attitudes towards the English course","volume":"11","author":"Ceylaner S. G.","year":"2018","journal-title":"English Language Teaching"},{"issue":"5","key":"e_1_2_12_5_1","first-page":"2835","article-title":"Mentoring and adult learning: Andragogy in action","volume":"3","author":"Chinnasamy J.","year":"2013","journal-title":"International Journal of Management Research and Reviews"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-5583-7_311"},{"key":"e_1_2_12_7_1","unstructured":"Commonwealth of Australia. (2020).Psychologists 2019 Factsheet.https:\/\/hwd.health.gov.au\/resources\/publications\/factsheet\u2010alld\u2010psychologists\u20102019.pdf"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/fmch\u20102018\u2010000057"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100100"},{"issue":"1","key":"e_1_2_12_10_1","first-page":"120","article-title":"The design of an online community of practice for beginning teachers","volume":"6","author":"Herrington A.","year":"2006","journal-title":"Contemporary Issues in Technology and Teacher Education"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajr.12727"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jan.13031"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1515\/fon-2018-0032"},{"key":"e_1_2_12_14_1","volume-title":"Behavioral activation for depression: A clincian's guide","author":"Martell C. 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Combining the two therapeutics increases the response rates compared to either treatment alone. However, this increased efficacy is accompanied by a higher incidence of severe immune-related adverse events (irAEs). Metrics of the intestinal microbiome are associated with cancer patients\u2019 responses to immunotherapy but the value of microbiome metrics as predictors for irAEs, are unknown. In an effort to reduce irAEs during combination neoadjuvant therapy, the OpACIN-neo trial (Rozeman et al. ESMO 2018) was initiated wherein Stage III melanoma patients were treated with 2 doses each of ipilimumab and nivolumab in the neoadjuvant setting, according to three dosing regimen. Involved lymph nodes were resected after 6 weeks.<\/jats:p>\n Aims: (1) To determine whether intestinal microbial components are associated with response to antiPD1\/anti-CTLA4 immunotherapy in the neoadjuvant setting or with the development of severe irAEs. (2) To determine the effects of antiPD1\/anti-CTLA4 immunotherapy on the microbiome over the 6 week course of treatment.<\/jats:p>\n Methods: Of Melanoma Institute Australia patients enrolled in the OpACIN-neo trial (n=38), 68% of patients experienced complete, or near complete pathological responses and 61% experienced at least one irAE of grade 3 or more. Faecal microbiomes at baseline, and at resection (6 weeks immunotherapy), were analyzed using 16S ribosomal gene and metagenomic sequencing and the results compared with patient response and development of G3-G5 irAEs. Results: In baseline samples, Inverse Simpson\u2019s diversity index indicated significantly lower overall microbial diversity in non-responders (p=.014), as well as those who went on to experience severe irAEs (p=.002). Importantly, the group of patients who were both non-responders and experienced severe irAEs had the lowest microbial diversity of all patients (p=.0033). Specific taxa associated with irAEs are distinct from those described for response. The 6 week course of immunotherapy led to a slight increase in microbial diversity but few specific taxa were observed to be significantly altered between the timepoints.<\/jats:p>\n Conclusions: The findings suggest that not only are patients with extremely low microbial diversity predisposed to develop severe irAEs but they are also unlikely to respond to combination immunotherapy. Thus, microbial diversity may delineate patients who are likely to have poor outcomes and would benefit from microbial modulation.<\/jats:p>\n Citation Format: Marcel Batten, Erin R. Shanahan, Ines P. Silva, Chandra Adhikari, Jordan Conway, Annie Tasker, Alexander M. Menzies, James S. Wilmott, Robyn P. Saw, Andrew J. Spillane, Kerwin F. Shannon, Christian U. Blank, Andrew J. Holmes, Richard A. Scolyer, Georgina V. Long. Low intestinal microbial diversity is associated with severe immune-related adverse events and lack of response to neoadjuvant combination antiPD1, anti-CTLA4 immunotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2822.<\/jats:p>","DOI":"10.1158\/1538-7445.am2019-2822","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T18:14:17Z","timestamp":1565201657000},"page":"2822-2822","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Abstract 2822: Low intestinal microbial diversity is associated with severe immune-related adverse events and lack of response to neoadjuvant combination antiPD1, anti-CTLA4 immunotherapy"],"prefix":"10.1158","volume":"79","author":[{"given":"Marcel","family":"Batten","sequence":"first","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin R.","family":"Shanahan","sequence":"additional","affiliation":[{"name":"2The University of Sydney, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines P.","family":"Silva","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra","family":"Adhikari","sequence":"additional","affiliation":[{"name":"3Royal Prince Alfred Hospital, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Conway","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Tasker","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander M.","family":"Menzies","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Wilmott","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn P.","family":"Saw","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Spillane","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerwin F.","family":"Shannon","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian U.","family":"Blank","sequence":"additional","affiliation":[{"name":"4Netherlands Cancer Institute, Amsterdam, Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Holmes","sequence":"additional","affiliation":[{"name":"2The University of Sydney, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Scolyer","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina V.","family":"Long","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/79\/13_Supplement\/2822\/634825\/Abstract-2822-Low-intestinal-microbial-diversity","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/79\/13_Supplement\/2822\/634825\/Abstract-2822-Low-intestinal-microbial-diversity","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T19:48:23Z","timestamp":1655840903000},"score":7.703188,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/79\/13_Supplement\/2822\/634825\/Abstract-2822-Low-intestinal-microbial-diversity"}},"issued":{"date-parts":[[2019,7,1]]},"references-count":0,"aliases":["10.1158\/1538-7445.sabcs18-2822"],"journal-issue":{"issue":"13_Supplement","published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2019-2822","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2019,7,1]]}},{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T21:29:41Z","timestamp":1764883781643,"version":"3.46.0"},"reference-count":60,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"unspecified","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100032244","name":"Perth 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Unfortunately, children with chronic health conditions have lower levels of physical activity compared to their healthy peers due to multiple restrictions in physical activities and therefore tend to have lower levels of physical activity compared with their peers. This paper describes the protocol for Move to Improve, a pragmatic trial of an individualised physical activity intervention for children with chronic health conditions.<\/jats:p>\n <\/jats:sec>\n \n Methods and analysis<\/jats:title>\n Using the RE-AIM framework, this study aims to test the feasibility of Move to Improve, an 8-week hospital-based individualised physical activity intervention. We will recruit 100 children aged 5\u201317 years who are diagnosed with type 1 diabetes, cancer, postburn injuries and cerebral palsy to a single-arm, pragmatic feasibility trial. The primary outcomes (objective moderate to vigorous physical activity, quality of life and goal attainment) and secondary outcomes (including aerobic capacity, body composition, motor function, grip strength and psychosocial outcomes) will be assessed at baseline, post intervention and at 6-month and 12-month follow-ups. We will conduct semistructured interviews with participants and their primary caregiver at a 2-month follow-up to capture aspects of feasibility. Quantitative data will be reported descriptively, and qualitative data will be analysed using thematic analysis. Data gathered from this study will inform service decision-making and future trials.<\/jats:p>\n <\/jats:sec>\n \n Ethics and dissemination<\/jats:title>\n The study has received ethics approval from the Government of Western Australia Child and Adolescent Health Service Human Research Ethics Committee (RGS6677). Findings of this research will be communicated to the public through peer-reviewed publications, conference presentations, reports, infographics and information sheets. Modifications to the protocol will be outlined in the trial registry and journal publications. 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We aimed to compare the trajectories of brain structure change in a sample of children with T1D to age-matched children without T1D. We recruited children presenting to a tertiary hospital in Australia between 1990 - 1992 into this prospective cohort study (Cognition and Longitudinal Assessment of Risk Factors over 30 Years (CLARiFY) Study). Brain magnetic resonance imaging (MRI) was performed at two time points, approximately 20 years apart. We examined for between-group differences in normalized brain volumes and cortical thickness (CT) across time using linear mixed models. A total of 127 images were available at timepoint 1 (77 with T1D, mean age=20 years, 43% female) and 68 at timepoint 2 (36 with T1D, mean age=37 years, 49% female). At timepoint 1, those with T1D had lower subcortical gray matter volume than those without T1D (p=0.01) but the remaining measures were similar. Across time, those with T1D had greater decline in cortical thickness (\u03b2=-2280, p=0.03) than those without T1D, with trajectories in other measures being similar (Table). In conclusion, these preliminary findings suggest that childhood-onset T1D is associated with lower subcortical gray matter and altered development of cortical gray matter over time.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n O.Gbadeyan: None. C.Moran: None. A.Brown: None. S.A.Sakowski: None. V.Srikanth: None. F.Cameron: None. E.A.Northam: None. E.L.Feldman: None. R.Beare: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Institutes of Health (R01DK129320)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-1328-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:24:37Z","timestamp":1687242277000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1328-P: Impact of Early Childhood-Onset Type 1 Diabetes on Brain Structural Trajectories (CLARiFY Study)"],"prefix":"10.2337","volume":"72","author":[{"given":"OYETUNDE","family":"GBADEYAN","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Ann Arbor, MI, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRIS","family":"MORAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Ann Arbor, MI, Frankston, 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These data indicate areal and stratigraphic constraints that support the program\u2019s further work in Stage 3, on understanding likely development scenarios, impact assessments and causal pathways.<\/jats:p>","DOI":"10.1071\/aj20035","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T02:22:09Z","timestamp":1625192529000},"page":"477-484","source":"Crossref","is-referenced-by-count":5,"title":["Geological and Bioregional Assessments: assessing the prospectivity for tight, shale and deep-coal resources in the Cooper Basin, Beetaloo Subbasin and Isa Superbasin"],"prefix":"10.1071","volume":"61","author":[{"given":"Lisa S.","family":"Hall","sequence":"first","affiliation":[{"name":"AGeoscience Australia, Symonston, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith L.","family":"Orr","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Symonston, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"Lech","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Symonston, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Lewis","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Symonston, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam H. 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Email: adam.bailey@ga.gov.au"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Owens","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Symonston, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry E.","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Symonston, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Bernardel","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Symonston, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2021,7,2]]},"reference":[{"key":"2025122721593780000_R1"},{"key":"2025122721593780000_R2"},{"issue":"2","key":"2025122721593780000_R3","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1071\/AJ17040","article-title":"Australia\u2019s premier shale basin: five plays, 1 000 000 000 years in the making","volume":"58","author":"C\u00f4t\u00e9","year":"2018","journal-title":"APPEA Journal"},{"key":"2025122721593780000_R4"},{"key":"2025122721593780000_R5"},{"key":"2025122721593780000_R6"},{"key":"2025122721593780000_R7"},{"key":"2025122721593780000_R8"},{"key":"2025122721593780000_R9"},{"key":"2025122721593780000_R10"},{"key":"2025122721593780000_R11"},{"key":"2025122721593780000_R12"},{"key":"2025122721593780000_R13"},{"key":"2025122721593780000_R14"},{"key":"2025122721593780000_R15"},{"key":"2025122721593780000_R16"},{"key":"2025122721593780000_R17","doi-asserted-by":"publisher","DOI":"10.15530\/URTEC-2014\u20131935073"}],"container-title":["The APPEA Journal"],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/61\/2\/477\/469090\/aj20035.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/61\/2\/477\/469090\/aj20035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T02:59:44Z","timestamp":1766890784000},"score":7.6994257,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/ep\/article\/61\/2\/477\/76876\/Geological-and-Bioregional-Assessments-assessing"}},"issued":{"date-parts":[[2021,7,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,7,2]]}},"URL":"https:\/\/doi.org\/10.1071\/aj20035","ISSN":["1326-4966","2206-8996"],"issn-type":[{"value":"1326-4966","type":"print"},{"value":"2206-8996","type":"electronic"}],"published":{"date-parts":[[2021,7,2]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:04Z","timestamp":1753889824734,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"We previously showed that a proactive inpatient diabetes service decreased adverse glycemia (AG) and hospital acquired infections (RAPIDS: ADA2017, 231-OR). To further focus our proactive care on high-risk inpatients, we investigated clinical risk factors associated with AG. We analyzed multiple clinical variables in 643 consecutive inpatients with diabetes or new hyperglycemia (random BG \u226511.1mmol\/L). Capillary BG from day 2 of admission until discharge (censored at day 14) were analyzed. AG was defined as BG &lt;4 or &gt;15mmol\/L on any day and recurrent AG (RAG) was defined as AG on \u22652 days. A split-sample multivariable logistical regression was performed with internal validation. The patient characteristics included 87% type 2 diabetes, 33% insulin-treated and mean HbA1c 7.6%. AG and RAG occurred in 278 (43%), and 176 (27%) patients respectively. Pre-hospital factors (sulphonylurea or insulin treatment, HbA1c, Charlson index) and in-hospital factors (dysglycemia on day 1, length of stay) were independently associated with both AG and RAG (Table). Glucocorticoid treatment was associated with RAG but not AG. A model using these multiple variables accurately identified AG (ROC-AUC 0.88). Age, diabetes type, creatinine and admission unit were not associated with either AG or RAG. This study identified multiple key clinical risk factors associated with adverse glycemia, and may be used to better concentrate efforts for inpatient diabetes care.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n M. Kyi: None. J.E. Reid: None. A. Gorelik: None. S.S. Kumar: None. A. Galligan: None. L.M. Rowan: Speaker's Bureau; Self; AstraZeneca, Sanofi, Novo Nordisk Inc.. A.J. Nankervis: None. K.A. Marley: None. D.M. Russell: None. P.R. Wraight: None. P.G. Colman: None. S. Fourlanos: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-1288-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:30Z","timestamp":1529693850000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Key Clinical Risk Factors Identify Adverse Glycemia in Hospitalized Patients"],"prefix":"10.2337","volume":"67","author":[{"given":"MERVYN","family":"KYI","sequence":"first","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANE E.","family":"REID","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALEXANDRA","family":"GORELIK","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHANAL 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We present our data on this cohort and follow\u2010up of our previous patients. Of the 23 patients who were commenced on this regime, 18 healed (78%). Twenty\u2010two patients commenced on this regime as the primary treatment for their PPG, and for one, it was a rescue remedy after failed conventional therapy. Four patients with significant medical comorbidities failed to heal and one had their stomal reversal surgery before being fully healed. The proposed treatment regime for PPG is demonstrated to be effective, inexpensive and able to be managed in the patient's usual home environment. In vitro drug release analysis was undertaken, and data are presented to provide further insights into the efficacy of this regime.<\/jats:p>","DOI":"10.1111\/iwj.14808","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T02:00:16Z","timestamp":1709258416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical efficacy of crushed prednisolone and hydrocolloid powder in the primary treatment of peristomal pyoderma gangrenosum and correlation to in vitro drug release data"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5216-6916","authenticated-orcid":false,"given":"Wendy Ann","family":"Pearson","sequence":"first","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"},{"name":"Curtin University Bentley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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Urology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.juro.2017.02.1159","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T18:40:17Z","timestamp":1491244817000},"source":"Crossref","is-referenced-by-count":0,"title":["MP38-06 ZERO HOSPITAL ADMISSIONS FOR INFECTION AFTER 1359 TRANSPERINEAL PROSTATE BIOPSIES"],"prefix":"10.1097","volume":"197","author":[{"given":"Lana","family":"Pepdjonovic","sequence":"first","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Huang","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Dat","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mann","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Frydenberg","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Moon","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Snow","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri","family":"Hanegbi","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Landau","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Grummet","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534717313836?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534717313836?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2017.02.1159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T04:50:05Z","timestamp":1651207805000},"score":7.6971607,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2017.02.1159"}},"issued":{"date-parts":[[2017,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1016\/j.juro.2017.02.1159"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2017.02.1159","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2017,4]]}},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T06:14:56Z","timestamp":1651212896288},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.juro.2018.02.2208","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T12:43:37Z","timestamp":1522759417000},"source":"Crossref","is-referenced-by-count":1,"title":["MP68-04 COMPARISON OF TWO DIGITAL, SINGLE USE FLEXIBLE URETERORENOSCOPES (BOSTON SCIENTIFIC LITHOVUE AND PUSEN PU3022)- A PROSPECTIVE STUDY"],"prefix":"10.1097","volume":"199","author":[{"given":"Jonathan","family":"Kam","sequence":"first","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuigi","family":"Yuminaga","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieran","family":"Beattie","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunny","family":"Nalavenkata","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan","family":"Arianayagam","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertram","family":"Canagasingham","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celi","family":"Varol","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Khadra","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Winter","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Ko","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534718415182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534718415182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2018.02.2208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:57:11Z","timestamp":1651211831000},"score":7.697072,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2018.02.2208"}},"issued":{"date-parts":[[2018,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1016\/j.juro.2018.02.2208"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2018.02.2208","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2018,4]]}},{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:04:21Z","timestamp":1780700661963,"version":"3.54.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2026,6,5]]},"abstract":"Introduction and Objective: Medical nutrition therapy underpins GDM management, yet evidence-based guidelines are needed. Greater morning insulin resistance often results in post-breakfast hyperglycemia in GDM. A low glycemic load (GL) diet reduces glucose concentrations and need for pharmacotherapy in GDM, but the impact of targeting breakfast only is unknown. In a randomized cross-over trial, we compared the effects of a low vs high GL breakfast (LGL-B vs HGL-B) on breakfast 1-h postprandial glucose (PPG) and 24-h glycemic variability (GV) (primary outcomes) within GDM women.<\/jats:p>\n Methods: Women were provided a LGL-B (245 kcal; carbohydrate: 10.9g) and HGL-B (247 kcal; carbohydrate: 43.4g) for 7d separated by a 7d washout. Fasting blood was drawn on day 1 and 7; a masked continuous glucose monitor was worn. PPG and GV (% coefficient of variation [%CV]) were averaged over 7d. Mixed effect models with Bonferroni corrections were conducted to compare between intervention effects within women.<\/jats:p>\n Results: Thirty women with diet managed GDM (median 34.5 yrs, BMI 28.1 kg\/m2) were randomized (26 wks\u2019 gestation). Compared to HGL-B, LGL-B decreased 1-h PPG (mean 134 mg\/dL [95% CI 129, 140] vs 89 mg\/dL [84, 94]) and 24-h %CV (19.5 [18.1, 21.0] vs 16.6 [15.2, 18.1]) (both p&lt;0.001). Triglycerides decreased over 7d on LGL-B and increased on HGL-B (time x intervention; p=0.047). There was no difference in ketones, satiety, or acceptability.<\/jats:p>\n Conclusion: Within women with GDM, a LGL-B improves breakfast PPG, GV, and potentially triglycerides. This approach may be a simple dietary recommendation to improve glycemia and reduce need for pharmacotherapy in women with GDM.<\/jats:p>\n \n Disclosure<\/jats:title>\n J. Burk: None. G.P. Ross: None. S. Colagiuri: None. G.D. Brinkworth: None. P.J. Taylor: None. E.G. Dunn: None. S. Hagen-Lillevik: None. M. Hivert: None. T.L. Hernandez: None. A. Sweeting: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Sydney Local Health District, Sydney Institute for Women, Children and their Families Seed Funding Grant 2022<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db26-1532-p","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:35:47Z","timestamp":1780698947000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1532-P: A Low-Glycemic Load Breakfast Improves Glycemia in Women with Gestational Diabetes (GDM): A Randomized Crossover Trial"],"prefix":"10.2337","volume":"75","author":[{"given":"JESSICA","family":"BURK","sequence":"first","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Millers Point NSW, Australia, Glebe, Australia, Adelaide, Australia, Aurora, CO, Hailey, ID, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GLYNIS P.","family":"ROSS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Millers Point NSW, Australia, Glebe, Australia, Adelaide, Australia, Aurora, CO, Hailey, ID, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEPHEN","family":"COLAGIURI","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Millers Point NSW, Australia, Glebe, Australia, Adelaide, Australia, Aurora, CO, Hailey, ID, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GRANT D.","family":"BRINKWORTH","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Millers Point NSW, Australia, Glebe, Australia, Adelaide, Australia, Aurora, CO, Hailey, ID, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PENNIE J.","family":"TAYLOR","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Millers Point NSW, Australia, Glebe, Australia, Adelaide, Australia, Aurora, CO, Hailey, ID, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EMILY G.","family":"DUNN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Millers Point NSW, Australia, Glebe, Australia, Adelaide, Australia, Aurora, CO, Hailey, ID, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SYNNEVA","family":"HAGEN-LILLEVIK","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Millers Point NSW, Australia, Glebe, Australia, Adelaide, Australia, Aurora, CO, Hailey, ID, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIE-FRANCE","family":"HIVERT","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Millers Point NSW, Australia, Glebe, Australia, Adelaide, Australia, Aurora, CO, Hailey, ID, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TERI L.","family":"HERNANDEZ","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Millers Point NSW, Australia, Glebe, Australia, Adelaide, Australia, Aurora, CO, Hailey, ID, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ARIANNE","family":"SWEETING","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia, Millers Point NSW, Australia, Glebe, Australia, Adelaide, Australia, Aurora, CO, Hailey, ID, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/1532-P\/169022\/1532-P-A-Low-Glycemic-Load-Breakfast-Improves","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/1532-P\/169022\/1532-P-A-Low-Glycemic-Load-Breakfast-Improves","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:35:47Z","timestamp":1780698947000},"score":7.6955266,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/1532-P\/169022\/1532-P-A-Low-Glycemic-Load-Breakfast-Improves"}},"issued":{"date-parts":[[2026,6,5]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2026,6,5]]}},"URL":"https:\/\/doi.org\/10.2337\/db26-1532-p","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2026,6,5]]},"article-number":"1532-P"},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:12:30Z","timestamp":1651209150098},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.juro.2016.02.515","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T07:33:03Z","timestamp":1459150383000},"source":"Crossref","is-referenced-by-count":0,"title":["MP53-18 ZERO SEPSIS IN 608 CONSECUTIVE TRANSPERINEAL PROSTATE BIOPSIES"],"prefix":"10.1097","volume":"195","author":[{"given":"Sean","family":"Huang","sequence":"first","affiliation":[{"name":"Armadale, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan Hee","family":"Tan","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mann","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wee Loon","family":"Ong","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Landau","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Snow","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri","family":"Hanegbi","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Moon","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Frydenberg","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Grummet","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002253471600803X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002253471600803X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2016.02.515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T04:57:58Z","timestamp":1651208278000},"score":7.695401,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2016.02.515"}},"issued":{"date-parts":[[2016,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1016\/j.juro.2016.02.515"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2016.02.515","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2016,4]]}},{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:41:20Z","timestamp":1758706880193},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,17]],"date-time":"2016-01-17T00:00:00Z","timestamp":1452988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Western Australian Department of Health"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Almost all skin cancers are the result of overexposure to UV<\/jats:styled-content> radiation and could be prevented by adhering to a number of simple behavioural guidelines to minimise exposure to the sun. The present study examined trends in sun\u2010protection behaviour among adults living in Western Australia, a region with high levels of UV<\/jats:styled-content> radiation.<\/jats:p><\/jats:sec>Methods<\/jats:title>During five summers from 2008 to 2012, 2076 Western Australian adults participated in annual, cross\u2010sectional telephone surveys that assessed how often they engaged in a range of sun\u2010protection behaviour (seeking shade, staying inside and wearing a hat, protective clothing, sunscreen or sunglasses).<\/jats:p><\/jats:sec>Results<\/jats:title>Apart from an increase in sunscreen use and a consistently high use of sunglasses, most sun\u2010protection behaviour remained stable at moderate levels during the 5\u2010year period. Seeking shade, staying inside and wearing a hat were all practised at levels ranging between \u2018sometimes\u2019 and \u2018usually\u2019 on sunny days in summer during peak UV<\/jats:styled-content> hours, with little to no variability across the survey years. Wearing protective clothing was the least frequent behaviour across all survey years and was significantly lower in the most recent survey year relative to baseline.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Further efforts are required to encourage greater enactment of sun\u2010protection behaviour, especially on the use of protective clothing and seeking shade during periods of high UV<\/jats:styled-content> radiation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12433","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T03:08:41Z","timestamp":1453086521000},"page":"111-116","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Trends in sun\u2010protection behaviour in Australian adults 2007\u20132012"],"prefix":"10.1111","volume":"58","author":[{"given":"Severine","family":"Koch","sequence":"first","affiliation":[{"name":"Curtin University Perth Western Australia 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Measures of self\u2010injury, mood and emergency department presentations were collected pre\u2010 and post\u2010programme.<\/jats:p><\/jats:sec>Results<\/jats:title>Results indicate that participants show a reduction in non\u2010suicidal acts and thoughts, as well as a reduction in negative moods and feelings from pre\u2010Touchstone to post\u2010Touchstone. 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We examined blood pressure (BP) in young people with T1D from ADDN, a prospective clinical diabetes registry in Australia and New Zealand. Inclusion criteria: T1D (duration \u22651 year) and age 16-25 years at last visit (2011-2020) . Hypertension was defined as (on \u22653 occasions) systolic BP (SBP) and\/or diastolic BP (DBP) &gt;95th percentile for age &lt;18 years, and SBP &gt;130 and\/or DBP &gt;80 mmHg for age \u226518 years. Data from 6,338 young people (male 52.6%) attending 24 participating centres across 36,655 T1D healthcare visits were included; 2,812 (44.4%) had BP measured at last visit (Table 1) . Across all visits, 19.4% of youth aged &lt;18 years and 21.7% of those aged \u226518 years met criteria for hypertension. Using multivariable Generalised Estimating Equations that included all visits, BP in the hypertensive range was associated with: male gender (B=0.36; 95% CI 0.01-0.24, p&lt;0.001) , injection vs. pump therapy (B=0.16; 0.05-0.28, p&lt;0.001) , higher HbA1c (B=0.10; 0.12-0.70, p&lt;0.001) and overweight\/obesity (B=0.56; 0.45-0.67, p&lt;0.001) . We demonstrate that hypertension is common in young people with T1D, highlighting the importance of monitoring and treating BP in this at-risk population.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n S.James: None. L.Perry: None. J.Lowe: None. P.G.Colman: None. M.E.Craig: None. Addn study group: n\/a.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db22-440-p","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:18:02Z","timestamp":1653974282000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["440-P: Suboptimal Blood Pressure in Adolescents and Young Adults with Type 1 Diabetes: Data from the Australasian Diabetes Data Network (ADDN) Registry"],"prefix":"10.2337","volume":"71","author":[{"given":"STEVEN","family":"JAMES","sequence":"first","affiliation":[{"name":"Petrie, Australia, Ultimo, Australia, Toronto, ON, Canada, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LIN","family":"PERRY","sequence":"additional","affiliation":[{"name":"Petrie, Australia, Ultimo, Australia, Toronto, ON, Canada, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JULIA","family":"LOWE","sequence":"additional","affiliation":[{"name":"Petrie, Australia, Ultimo, Australia, Toronto, ON, Canada, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER G.","family":"COLMAN","sequence":"additional","affiliation":[{"name":"Petrie, Australia, Ultimo, Australia, Toronto, ON, Canada, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA E.","family":"CRAIG","sequence":"additional","affiliation":[{"name":"Petrie, Australia, Ultimo, Australia, Toronto, ON, Canada, Parkville, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"ADDN STUDY GROUP","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/440-P\/145299\/440-P-Suboptimal-Blood-Pressure-in-Adolescents-and","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/440-P\/145299\/440-P-Suboptimal-Blood-Pressure-in-Adolescents-and","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:18:03Z","timestamp":1653974283000},"score":7.6933804,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/440-P\/145299\/440-P-Suboptimal-Blood-Pressure-in-Adolescents-and"}},"issued":{"date-parts":[[2022,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db22-440-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2022,6,1]]},"article-number":"440-P"},{"indexed":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T09:15:19Z","timestamp":1656580519103},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"24_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2013,12,15]]},"abstract":"Abstract<\/jats:title>\n Background: Australian clinical guidelines recommend post-surgical endocrine therapy for all women with early, hormone-dependent breast cancer. Guidelines specify tamoxifen as first-line therapy for pre-menopausal women, and either tamoxifen or an aromatase inhibitor for post-menopausal women depending on their risk of recurrence which is based on tumour size and other prognostic indicators. Tamoxifen and the aromatase inhibitors have different side effect profiles and therefore comorbidity may also influence choice of therapy. We examined comorbidities, and the clinical and demographic characteristics of women initiated on different endocrine therapies for breast cancer in Australian practice.<\/jats:p>\n Method: We identified the first dispensing of tamoxifen, anastrozole or letrozole for women diagnosed with invasive breast cancer in the 45 and Up Study between January 2003 and December 2009 (n = 1383). Unit-level pharmacy and medical service claims, hospital separations, and Cancer Registry records were linked to self-reported data to determine menopause status at diagnosis, tumour size, age, change in subsidy restrictions, and specified comorbidities which may affect choice of therapy (i.e. arthritis, endometrial cancer, osteoporosis, thromboembolism). Chi-square tests and multivariate generalised linear models were used to compare the characteristics of post-menopausal women initiated on different therapies.<\/jats:p>\n Results: The majority of pre-menopausal women commenced therapy with tamoxifen (93%). Tamoxifen was the predominant therapy for post-menopausal women with tumours \u22641cm (54%), and anastrozole most common for those with larger tumours (49%). Post-menopausal women with osteoporosis were less likely to commence an aromatase inhibitor compared with tamoxifen (anastrozole RR = 0.7, 95%CI = 0.5-0.9, P = 0.019; letrozole RR = 0.6, 95%CI = 0.3-0.9, P = 0.033) and those with arthritis were 1.6-times more likely to commence with letrozole than anastrozole (95%CI = 1.6-2.3, P = 0.004). Tamoxifen was more likely to be initiated in women with large tumours who also had comorbid arthritis or were aged \u226575 years. Changes in subsidy restrictions were associated with significant increases in the proportion of post-menopausal women commencing an aromatase inhibitor rather than tamoxifen (anastrozole RR = 7.0; letrozole RR = 18.5).<\/jats:p>\n Conclusions: The findings show clinical guidelines regarding endocrine therapies are being followed in Australian practice, particularly in relation to menopause status and tumour size as a recurrence risk factor. The findings also indicate there is interplay of comorbidity and choice of therapy for older women and those with arthritis or osteoporosis.<\/jats:p>\n Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P1-13-16.<\/jats:p>","DOI":"10.1158\/0008-5472.sabcs13-p1-13-16","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T22:26:43Z","timestamp":1408055203000},"page":"P1-13-16-P1-13-16","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract P1-13-16: Women commencing with anastrozole, letrozole or tamoxifen: The impact of comorbidity and demographics on initial choice"],"prefix":"10.1158","volume":"73","author":[{"given":"F","family":"Boyle","sequence":"first","affiliation":[{"name":"The Mater Hospital, Sydney, New South Wales, Australia; The University of Western Australia, Perth, Western Australia, Australia; University of Notre Dame, Perth, Western Australia, Australia; University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Kemp","sequence":"additional","affiliation":[{"name":"The Mater Hospital, Sydney, New South Wales, Australia; The University of Western Australia, Perth, Western Australia, Australia; University of Notre Dame, Perth, Western Australia, Australia; University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DB","family":"Preen","sequence":"additional","affiliation":[{"name":"The Mater Hospital, Sydney, New South Wales, Australia; The University of Western Australia, Perth, Western Australia, Australia; University of Notre Dame, Perth, Western Australia, Australia; University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Saunders","sequence":"additional","affiliation":[{"name":"The Mater Hospital, Sydney, New South Wales, Australia; The University of Western Australia, Perth, Western Australia, Australia; University of Notre Dame, Perth, Western Australia, Australia; University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bulsara","sequence":"additional","affiliation":[{"name":"The Mater Hospital, Sydney, New South Wales, Australia; The University of Western Australia, Perth, Western Australia, Australia; University of Notre Dame, Perth, Western Australia, Australia; University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Malacova","sequence":"additional","affiliation":[{"name":"The Mater Hospital, Sydney, New South Wales, Australia; The University of Western Australia, Perth, Western Australia, Australia; University of Notre Dame, Perth, Western Australia, Australia; University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EE","family":"Roughead","sequence":"additional","affiliation":[{"name":"The Mater Hospital, Sydney, New South Wales, Australia; The University of Western Australia, Perth, Western Australia, Australia; University of Notre Dame, Perth, Western Australia, Australia; University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/73\/24_Supplement\/P1-13-16\/585108\/Abstract-P1-13-16-Women-commencing-with","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/73\/24_Supplement\/P1-13-16\/585108\/Abstract-P1-13-16-Women-commencing-with","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T08:36:48Z","timestamp":1656578208000},"score":7.6929955,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/73\/24_Supplement\/P1-13-16\/585108\/Abstract-P1-13-16-Women-commencing-with"}},"issued":{"date-parts":[[2013,12,15]]},"references-count":0,"journal-issue":{"issue":"24_Supplement","published-print":{"date-parts":[[2013,12,15]]}},"URL":"https:\/\/doi.org\/10.1158\/0008-5472.sabcs13-p1-13-16","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2013,12,15]]}},{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:27:49Z","timestamp":1787246869073,"version":"build-2736575974"},"reference-count":0,"publisher":"Society of Exploration Geophysicists","content-domain":{"domain":[],"crossmark-restriction":false},"abstract":"Drilling of Phoenix South-1 (PS-1) in 2014 in the Bedout Sub-basin, NW Shelf Australia, supports an active oil dominated petroleum system in an area previously thought to be gas prone. Four independent oil columns were encountered in the Lower-Mid Triassic Keraudren Fm over a 315m gross interval, with a combined 151m oil column. PS-1 tested a 4-way dip closure, in an overall fault bounded structure controlled by N-S oriented faults covering an area of ~45km2. Closure to the north and south is dip-controlled, spilling to the north towards the Phoenix-1 well and the undrilled Roc closure to the south. The depositional environment for the Lower Keraudren Fm reservoir sands has been interpreted historically as fluvial channel sands to nearshore marine or even pro-deltaic sequences. Analysis of palynology, XRD, SWCs and FMI logs from the dominantly fine-medium grained sandstone packages in PS-1 indicates a likely non-marine to marginal marine sequence. The hydrocarbon charged interval in PS-1 appears to be sealed by a highly cemented, fine grained clastic zone related to a marine incursion. The individual reservoir units have overlying 20-40m claystones acting as intra-formational seals to the oil columns encountered. Several faults and fractures were recognised on the well FMI image, and together with an uncharacteristically low fracture gradient that may be bounded at the low end by frictional equilibrium conditions, may have implications for development. Analyses of oil samples collected by MDT from three of the reservoir zones in the Keraudren indicate a mixed terrestrial-marginal marine source facies. Isotope characterization of the oils and related gases point to a complex maturity and migration story for the different reservoirs. Comparison of the various geochemical characteristics of the oils, including biomarkers and isotopes, to published data suggests that the source rock is not related to known petroleum systems on the North West Shelf. Although the proven Keraudren will be the focus of future regional exploration and drilling, several other plays are recognised within the sub-basin that have the potential to be charged by the same source, including the Permian and Lower to Middle Jurassic. The recent discovery at Phoenix South-1 has highlighted the potential for non-traditional oil plays in deeper Triassic reservoirs to be effective and shows the potential for other sparsely explored areas of the North West Shelf to rise from the ashes of obscurity.<\/jats:p>","DOI":"10.1190\/ice2015-2210048","type":"proceedings-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T14:10:38Z","timestamp":1458223838000},"page":"476-476","source":"Crossref","is-referenced-by-count":2,"title":["Phoenix South: A New Petroleum System in the Bedout Sub-Basin"],"prefix":"10.1190","volume":"1","author":[{"given":"Melissa","family":"Thompson*","sequence":"additional","affiliation":[{"name":"(1) Quadrant Energy Australia Limited, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shona","family":"MacDonald","sequence":"additional","affiliation":[{"name":"(1) Quadrant Energy Australia Limited, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Jablonski","sequence":"additional","affiliation":[{"name":"(2) Finder Exploration Ltd, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Molyneux","sequence":"additional","affiliation":[{"name":"(3) Carnarvon Petroleum Ltd, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Purcell","sequence":"additional","affiliation":[{"name":"(4) JX Nippon Oil & Gas Exploration (Australia) Pty Ltd, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Edgley","sequence":"additional","affiliation":[{"name":"(1) Quadrant Energy Australia Limited, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Isherwood","sequence":"additional","affiliation":[{"name":"(1) Quadrant Energy Australia Limited, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Ryan","sequence":"additional","affiliation":[{"name":"(1) Quadrant Energy Australia Limited, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Kelly","sequence":"additional","affiliation":[{"name":"(1) Quadrant Energy Australia Limited, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"186","published-online":{"date-parts":[[2015,9,16]]},"event":{"name":"International Conference and Exhibition, Melbourne, Australia 13-16 September 2015","location":"Melbourne, Australia","acronym":"icemelbourne2015","start":{"date-parts":[[2015,9,13]]},"end":{"date-parts":[[2015,9,16]]}},"container-title":["Global Meeting Abstracts","International Conference and Exhibition, Melbourne, Australia 13-16 September 2015"],"link":[{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/476\/714563","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/476\/714563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:51:43Z","timestamp":1787244703000},"score":7.6927886,"resource":{"primary":{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/476\/714563"}},"issued":{"date-parts":[[2015,9,16]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1190\/ice2015-2210048","ISSN":["2159-6832"],"issn-type":[{"value":"2159-6832","type":"electronic"}],"published":{"date-parts":[[2015,9,16]]}},{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T04:11:54Z","timestamp":1747368714654,"version":"3.40.5"},"reference-count":0,"publisher":"Clinical Exercise Physiology Association","issue":"s2","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2024,5]]},"abstract":"\n INTRODUCTION AND AIMS<\/jats:title>\n Telerehabilitation is increasingly acknowledged, though uptake remains limited by an inability to accurately undertake objective measurement. This study sought to determine the validity of a human pose estimation tool (PhysioROM, Coviu) assessed via two-dimensional (2D) video to measure active knee flexion and extension movement during common rehabilitation exercises, versus gold-standard three-dimensional (3D) motion capture.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Fifty participants were recruited (aged 18 to 30), each performing three common knee rehabilitation exercises; sit-to-stand, seated and reclined active knee flexion. Movements were recorded using the 12-camera, 3D Vicon motion capture system simultaneously with 2D video simulating a home telehealth consultation. Joint kinematics were calculated using the Vicon Plug-in Gait model (3D Vicon) or the human pose estimation tool within the PhysioROM algorithm (2D PhysioROM).<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Mean peak knee flexion was 3.1\u00b0, 9.9\u00b0 and 24.8\u00b0 (p<0.001) greater for 3D Vicon versus 2D PhysioROM (sit-to-stand, seated flexion and reclined flexion, respectively). For peak knee extension, Vicon 3D was 2.4\u00b0 and 1.93\u00b0 greater than 2D PhysioROM in sit-to-stand (p=0.020) and seated flexion (p< 0.001), whilst 3.6\u00b0 less than PhysioROM for reclined knee flexion (p=0.030). Statistical parametric mapping revealed significant differences between Vicon 3D and PhysioROM for 71% and 42% of timepoints (p<0.001) for seated and reclined movements, clustered around full knee flexion. Significant differences were also found at an additional 37% (p<0.001) of timepoints clustered around knee extension for reclined postures. Overall mean absolute deviation was 8.7\u00b0, 7.6\u00b0 and 16.5\u00b0 for sit-to-stand, seated flexion and reclined flexion, respectively.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n Validity of PhysioROM to accurately measure knee flexion was high, less so in extension, during sit-to stand movements in a seated posture. Measurement in a reclined position were less accurate. PhysioROM may provide an effective method of accurately and objectively quantifying knee movement during a telerehabilitation session using 2D video.<\/jats:p>\n <\/jats:sec>","DOI":"10.31189\/2165-7629-13-s2.397","type":"journal-article","created":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T14:41:58Z","timestamp":1714920118000},"page":"397","source":"Crossref","is-referenced-by-count":0,"title":["TELEREHABILITATION ASSESSMENT OF KNEE RANGE OF MOVEMENT; COMPARISON OF HUMAN POSE ESTIMATION TOOL, PHYSIOROM, VS 3D MOTION CAPTURE SYSTEM"],"prefix":"10.31189","volume":"13","author":[{"given":"Mr Ray","family":"Seaby","sequence":"first","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"},{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dr Jay","family":"Ebert","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"},{"name":"HFRC, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dr Brendan","family":"Joss","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"},{"name":"HFRC, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dr Peter","family":"Edwards","sequence":"additional","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"},{"name":"Orthopaedic Research Foundation of Western Australia, Claremont, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prof Tim","family":"Ackland","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16145","container-title":["Journal of Clinical Exercise Physiology"],"link":[{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/13\/s2\/article-p397-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/jcep\/article-pdf\/13\/s2\/397\/3369376\/i2165-7629-13-s2-397.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/13\/s2\/article-p397-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/13\/s2\/article-p397-s.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:40:31Z","timestamp":1747356031000},"score":7.6924596,"resource":{"primary":{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/13\/s2\/article-p397-s.xml"}},"issued":{"date-parts":[[2024,5]]},"references-count":0,"journal-issue":{"issue":"s2"},"URL":"https:\/\/doi.org\/10.31189\/2165-7629-13-s2.397","ISSN":["2165-7629","2165-6193"],"issn-type":[{"type":"electronic","value":"2165-7629"},{"type":"print","value":"2165-6193"}],"published":{"date-parts":[[2024,5]]}},{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T23:17:41Z","timestamp":1763507861336,"version":"3.45.0"},"reference-count":11,"publisher":"CSIRO Publishing","issue":"2","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":358,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2024,5,16]]},"abstract":"The \u2018Australia\u2019s Future Energy Resources\u2019 (AFER) project, funded under the Government\u2019s \u2018Exploring for the Future\u2019 (EFTF) program has been completed. The project\u2019s four modules have evaluated a mixture of energy resource commodities, including natural gas, hydrogen, subsurface storage opportunities for carbon dioxide and hydrogen. They are complemented by several targeted basin inventories which outline the current geological knowledge of energy resources in underexplored, data-poor regions. Several publicly available data sets have been generated and published under the AFER project, including 3750\u2009line-km of reprocessed 2D seismic data, acquired in the Pedirka and western Eromanga basins, of which key lines have been interpreted and integrated with geological and petrophysical well log data. Relative prospectivity maps have been produced for five energy resource commodities from 14 play intervals to show the qualitative variability in prospectivity of these resources, including quantitative resource assessments where warranted. Results from the AFER project have helped to identify and geologically characterise the required energy resource commodities to accelerate Australia\u2019s path to net zero emissions.<\/jats:p>","DOI":"10.1071\/ep23059","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T20:10:49Z","timestamp":1715803849000},"page":"S325-S331","source":"Crossref","is-referenced-by-count":0,"title":["Australia\u2019s Future Energy Resources project: the untapped potential of onshore low carbon energy resources"],"prefix":"10.1071","volume":"64","author":[{"given":"Thomas","family":"Bernecker","sequence":"first","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Iwanec","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Bradey","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Owens","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Feitz","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Kalinowski","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidena","family":"Carr","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"2025111818162670700_R1","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1071\/AJ20044","article-title":"Hydrogen in Australian natural gas: occurrences, sources and resources.","volume":"61","author":"Boreham","year":"2021","journal-title":"The APPEA Journal"},{"key":"2025111818162670700_R2","doi-asserted-by":"publisher","first-page":"S392","DOI":"10.1071\/AJ21097","article-title":"A regional chronostratigraphic framework for play-based resource assessments in the Eromanga Basin.","volume":"62","author":"Bradshaw","year":"2022","journal-title":"The APPEA Journal"},{"key":"2025111818162670700_R3"},{"key":"2025111818162670700_R4"},{"key":"2025111818162670700_R5","doi-asserted-by":"publisher","first-page":"S251","DOI":"10.1071\/AJ22150","article-title":"Underexplored but not forgotten: assessing the energy resources potential of the greater Pedirka Basin region through play-based mapping.","volume":"63","author":"Iwanec","year":"2023","journal-title":"The APPEA Journal"},{"key":"2025111818162670700_R6","doi-asserted-by":"publisher","first-page":"S154","DOI":"10.1071\/EP23104","article-title":"The potential for CO2 storage in residual oil zones in onshore Australian basins.","volume":"64","author":"Kalinowski","year":"2024","journal-title":"Australian Energy Producers Journal"},{"key":"2025111818162670700_R7"},{"key":"2025111818162670700_R8"},{"key":"2025111818162670700_R9"},{"key":"2025111818162670700_R10"},{"key":"2025111818162670700_R11"}],"container-title":["Australian Energy Producers Journal"],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/64\/2\/S325\/165666\/ep23059.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/64\/2\/S325\/165666\/ep23059.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T23:16:32Z","timestamp":1763507792000},"score":7.6924596,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/ep\/article\/64\/2\/S325\/23561\/Australia-s-Future-Energy-Resources-project-the"}},"issued":{"date-parts":[[2024,5,16]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,5,16]]}},"URL":"https:\/\/doi.org\/10.1071\/ep23059","ISSN":["2982-0308"],"issn-type":[{"type":"electronic","value":"2982-0308"}],"published":{"date-parts":[[2024,5,16]]}},{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T01:55:57Z","timestamp":1773107757249,"version":"3.50.1"},"reference-count":0,"publisher":"Clinical Exercise Physiology Association","issue":"s2","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2024,5]]},"abstract":"\n INTRODUCTION AND AIMS<\/jats:title>\n Telerehabilitation is widely acknowledged, but its adoption in musculoskeletal cohorts has been restricted due to challenges in accurately measuring objective parameters such as range of movement (ROM). This research assesses the accuracy of a human pose estimation tool utilising two-dimensional (2D) video (PhysioROM, Coviu) for evaluating active hip flexion and abduction ROM during common rehabilitation exercises, compared to three-dimensional (3D) motion capture.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Fifty participants (18 to 80 years) were recruited, each performing three common hip movements; standing hip flexion, standing hip abduction and a sit-to-stand. The motions were captured using the 12-camera, 3D Vicon motion capture system in conjunction with simultaneous 2D video, simulating a home telehealth consultation scenario. Joint kinematics were computed using either the Vicon Plug-in Gait model (3D Vicon) or the human pose estimation tool integrated into the PhysioROM algorithm (2D PhysioROM).<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n No significant differences were observed in peak hip ROM measurements during the tasks undertaken. Mean peak hip flexion was 2.4\u00b0 (p=1.0) less for 3D Vicon versus 2D PhysioROM in standing hip flexion, though 2.1\u00b0 (p=0.46) greater during sit-to-stand movement. Hip abduction was 5.3\u00b0 (p< 0.001) less for 3D Vicon versus 2D PhysioROM in standing hip abduction. Statistical parametric mapping revealed significant differences (p<0.001) in hip flexion between Vicon 3D and 2D PhysioROM for 32% of timepoints for both standing hip flexion and sit-to-stand movements, clustered around full hip extension. During standing hip abduction, significant differences (p<0.001) were found at 58% of timepoints clustered around neutral postures. Overall mean absolute deviation was 10.1\u00b0, 9.7\u00b0 and 9.0\u00b0 for hip flexion\/extension, sit-to-stand, and hip abduction respectively.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n Validity of PhysioROM to accurately measure peak hip flexion and peak hip abduction was high. PhysioROM may provide an effective method of accurately and objectively quantifying hip movement during a telerehabilitation session using 2D video.<\/jats:p>\n <\/jats:sec>","DOI":"10.31189\/2165-7629-13-s2.396","type":"journal-article","created":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T14:41:56Z","timestamp":1714920116000},"page":"396","source":"Crossref","is-referenced-by-count":1,"title":["REAL-TIME HIP RANGE OF MOVEMENT MEASUREMENT IN TELEREHABILITATION; COMPARISON OF HUMAN POSE ESTIMATION TOOL, PHYSIOROM, VS 3D MOTION CAPTURE SYSTEM"],"prefix":"10.31189","volume":"13","author":[{"given":"Mr Ray","family":"Seaby","sequence":"first","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"},{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dr Jay","family":"Ebert","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"},{"name":"HFRC, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dr Brendan","family":"Joss","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"},{"name":"HFRC, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dr Peter","family":"Edwards","sequence":"additional","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"},{"name":"Orthopaedic Research Foundation of Western Australia, Claremont, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prof Tim","family":"Ackland","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16145","container-title":["Journal of Clinical Exercise Physiology"],"link":[{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/13\/s2\/article-p396-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/jcep\/article-pdf\/13\/s2\/396\/3369378\/i2165-7629-13-s2-396.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/13\/s2\/article-p396-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/13\/s2\/article-p396-s.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:40:30Z","timestamp":1747356030000},"score":7.6921577,"resource":{"primary":{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/13\/s2\/article-p396-s.xml"}},"issued":{"date-parts":[[2024,5]]},"references-count":0,"journal-issue":{"issue":"s2"},"URL":"https:\/\/doi.org\/10.31189\/2165-7629-13-s2.396","ISSN":["2165-7629","2165-6193"],"issn-type":[{"value":"2165-7629","type":"electronic"},{"value":"2165-6193","type":"print"}],"published":{"date-parts":[[2024,5]]}},{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T15:20:49Z","timestamp":1769786449709,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2014208"],"award-info":[{"award-number":["GNT2014208"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1175509"],"award-info":[{"award-number":["GNT1175509"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012155","name":"Channel 7 Telethon Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024253","name":"Western Australian Future Health and Innovation Fund, Government of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024253","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Integrating First Nations knowledge systems and Western research methodologies recognizes the strength, experience, and insight of First Nations peoples in addressing health issues in their communities. In research, this includes projects being led by First Nations Elders and peoples, including First Nations researchers in the team, and collecting data in ways that reflect First Nations ways of knowing, being, and doing. In this paper, we reflect upon the Koolungar (\n children<\/jats:italic>\n ) Moorditj (\n strong<\/jats:italic>\n ) Healthy Skin Project; operational in Perth and Bunbury, Western Australia, Australia, where the traditional custodians are the Noongar Aboriginal people. This Aboriginal Elder co\u2010designed project is presented as a case study to illustrate the practical use of The Kids Research Institute Australia Standards for the Conduct of Aboriginal Health Research, in striving towards best practice in Aboriginal pediatric dermatology research. It leads into The Koolungar (\n children<\/jats:italic>\n ) Moorditj (\n strong<\/jats:italic>\n ) Healthy Skin Project Part II manuscript, in which we present cross\u2010sectional studies of Aboriginal children attending community skin screening weeks.\n <\/jats:p>","DOI":"10.1111\/pde.70018","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T08:57:20Z","timestamp":1758185840000},"page":"20-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Koolungar (\n \n Children<\/i>\n <\/scp>\n ) Moorditj (\n \n Strong<\/i>\n <\/scp>\n ) Healthy Skin Project Part I: Conducting First Nations Research in Pediatric Dermatology"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5902-040X","authenticated-orcid":false,"given":"Bernadette M.","family":"Ricciardo","sequence":"first","affiliation":[{"name":"University of Western Australia Crawley Australia"},{"name":"The Kids Research Institute Australia Nedlands Australia"},{"name":"Perth Children's Hospital Nedlands Australia"},{"name":"Fiona Stanley Hospital Murdoch Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4261-2094","authenticated-orcid":false,"given":"Jacinta","family":"Walton","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel","family":"Nannup","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Australia"},{"name":"The Kids Research Institute Australia Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Tilbrook","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather\u2010Lynn","family":"Kessaris","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Australia"},{"name":"Fiona Stanley Hospital Murdoch Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1789-5570","authenticated-orcid":false,"given":"Ainslie","family":"Poore","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taleah","family":"Ugle","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Australia"},{"name":"The Kids Research Institute Australia Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Michie","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad","family":"Farrant","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Australia"},{"name":"The Kids Research Institute Australia Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Bridge","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelli","family":"McIntosh","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3899-5250","authenticated-orcid":false,"given":"S. Prasad","family":"Kumarasinghe","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asha C.","family":"Bowen","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Australia"},{"name":"The Kids Research Institute Australia Nedlands Australia"},{"name":"Perth Children's Hospital Nedlands Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Culture is Key: Towards Cultural Determinants\u2010Driven Health Policy","author":"Lowitja Institute","year":"2020"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14443050309387838"},{"key":"e_1_2_8_4_1","volume-title":"Telethon Kids Institute Guidelines for the Standards for the Conduct of Aboriginal Health Research","year":"2022"},{"key":"e_1_2_8_5_1","volume-title":"National Statement on Ethical Conduct in Human Research","author":"National Health and Medical Research Council","year":"2023"},{"key":"e_1_2_8_6_1","volume-title":"Ethical Conduct in Research With Aboriginal and Torres Strait Islander Peoples and Communities: Guidelines for Researchers and Stakeholders","author":"National Health and Medical Research Council","year":"2018"},{"key":"e_1_2_8_7_1","volume-title":"Keeping Research on Track II: A Companion Document to Ethical Conduct in Research With Aboriginal and Torres Strait Islander Peoples and Communities: Guidelines for Researchers and Stakeholders","author":"National Health and Medical Research Council","year":"2018"},{"key":"e_1_2_8_8_1","volume-title":"Code of Ethics for Aboriginal and Torres Strait Islander Research","author":"Australian Institute of Aboriginal and Torres Strait Islander Studies","year":"2020"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40814\u2010023\u201001428\u20106"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.31128\/AJGP\u201003\u201024\u20107177"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.14363"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.14221\/2653\u20103219.1034"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15153"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12961\u2010020\u20100528\u20109"},{"key":"e_1_2_8_15_1","volume-title":"Fred Hollows: An Autobiography","author":"Hollows F.","year":"1991"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1071\/PY23201"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.22459\/CAEPR38.11.2016"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12939\u2010022\u201001738\u2010w"},{"key":"e_1_2_8_19_1","volume-title":"Kaal Tackles Eczema","author":"Ricciardo B. M.","year":"2024"},{"key":"e_1_2_8_20_1","volume-title":"National Healthy Skin Guideline: For the Diagnosis, Treatment and Prevention of Skin Infections for Aboriginal and Torres Strait Islander Children and Communities in Australia","author":"The Australian Healthy Skin Consortium","year":"2023"}],"container-title":["Pediatric Dermatology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.70018","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.70018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T01:29:38Z","timestamp":1769736578000},"score":7.6916595,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.70018"}},"issued":{"date-parts":[[2025,9,18]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/pde.70018"],"URL":"https:\/\/doi.org\/10.1111\/pde.70018","archive":["Portico"],"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"published":{"date-parts":[[2025,9,18]]},"assertion":[{"value":"2024-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:18:42Z","timestamp":1715645922424},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"suppl_1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2014,3,25]]},"abstract":"\n Introduction:<\/jats:bold>\n Hypertension is the greatest contributor to mortality globally, and its prevalence is high in low to middle income countries (LMICs). High salt intake and poor dietary choices are associated with the risk of hypertension, but their role in rural areas of LMICs is unclear.\n <\/jats:p>\n Hypotheses: We aimed to establish the prevalence of high salt intake and to examine whether there is a clear relationship between high salt intake and hypertension in disadvantaged rural settings. We also aimed to assess the available information about the association of hypertension with other dietary factors.<\/jats:p>\n \n Methods:<\/jats:bold>\n We searched electronic databases to identify studies in rural LMICs, in which the association of salt and other dietary factors with hypertension were assessed using multivariable models. A meta-analysis was conducted to assess these associations using a random effects model.\n <\/jats:p>\n \n Results:<\/jats:bold>\n We identified 13 studies with a total of 134,404 participants for the systematic review. The pooled effect sizes (ESs) and 95% confidence intervals (CIs) for studies in which salt intake was assessed as a categorical variable (n=5) were 1.31 (95% CI: 1.19,1.44) in all participants, 1.70 (0.99,2.92) in males and 1.27 (95% CI: 1.04,1.54) in females. We also found a positive association between fat intake and the risk of hypertension (n=2) 1.47 (95% CI: 1.13, 1.90).There were few studies of other dietary factors and hypertension in rural regions of LMICs.\n <\/jats:p>\n \n Conclusions:<\/jats:bold>\n To the best of our knowledge, no other systematic review and or meta-analyses have been conducted to investigate the relationship between diet and hypertension in rural populations of LMICs. Our findings show that high salt intake is a significant risk factor for hypertension in rural areas of LMICs. We also show a large gap in the literature regarding the relationship between dietary factors other than salt with the risk of hypertension. Salt reduction strategies should be implemented on a community level in these populations in order to drive a change in dietary behaviour.\n <\/jats:p>","DOI":"10.1161\/circ.129.suppl_1.p386","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T01:06:33Z","timestamp":1625274393000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract P386: Salt is an Important Risk Factor for Hypertension in Rural Disadvantaged Populations"],"prefix":"10.1161","volume":"129","author":[{"given":"Asvini K","family":"Subasinghe","sequence":"first","affiliation":[{"name":"Monash Univ, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simin","family":"Arabshahi","sequence":"additional","affiliation":[{"name":"Monash Univ, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doreen","family":"Busingye","sequence":"additional","affiliation":[{"name":"Monash Univ, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger G","family":"Evans","sequence":"additional","affiliation":[{"name":"Monash Univ, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Z","family":"Walker","sequence":"additional","affiliation":[{"name":"Monash Univ, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela A","family":"Riddell","sequence":"additional","affiliation":[{"name":"Monash Univ, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda G","family":"Thrift","sequence":"additional","affiliation":[{"name":"Monash Univ, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00003017-201403251-00523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T20:47:23Z","timestamp":1715633243000},"score":7.6910214,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/circ.129.suppl_1.p386"}},"issued":{"date-parts":[[2014,3,25]]},"references-count":0,"journal-issue":{"issue":"suppl_1","published-print":{"date-parts":[[2014,3,25]]}},"alternative-id":["10.1161\/circ.129.suppl_1.p386"],"URL":"https:\/\/doi.org\/10.1161\/circ.129.suppl_1.p386","ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"published":{"date-parts":[[2014,3,25]]},"assertion":[{"value":"2018-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:38:14Z","timestamp":1753889894644,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Objectives: It is now well documented that adolescents with T1D are at greater risk for elevated anxiety than young people without diabetes. In addition, higher levels of state anxiety are associated with higher haemoglobin A1c (HbA1c), less frequent blood glucose monitoring, and more poorly controlled diabetes. Anxiety is also predictive of poor glycaemic control as far as 12 months into the future. To better understand how stress and anxiety may be related to moment-to-moment fluctuations in blood glucose levels, we used a novel method of measuring changes in emotional state in real time, known as experience sampling methodology (ESM), in combination with continuous glucose monitoring (CGM) technology.<\/jats:p>\n Methods: ESM is an ambulatory research method whereby participants respond to questions sent via a smartphone \u2018app\u2019 at multiple times throughout the day. In this study, adolescents (n= 53) diagnosed with T1D (aged 12-18 years) responded to questions regarding their current emotional state 10 times a day, over a 10-day period.<\/jats:p>\n Results: Preliminary analysis, using multilevel regression modelling, explored the relationships between anxiety and measures of glycaemic control. The following measures of glycaemic control were examined: concurrent sensor glucose (SGL), mean sensor glucose in the previous 60 minutes, and standard deviation (SD) of sensor glucose in the previous 60 minutes. The results of the model indicated that a quadratic term for concurrent SGL (p &lt; 0.001) and SD of sensor glucose (p = 0.005) were significant independent predictors of anxiety. The relationship between concurrent SGL and anxiety was U-shaped, with the vertex (minimum) of 7.8 mmol\/L.<\/jats:p>\n Conclusions: These novel findings confirm that elevated anxiety is associated with sub-optimal blood glucose levels in the preceding hour. Further analysis of this data will explore this relationship in greater detail, including possible inter-individual variation in this pattern.<\/jats:p>\n \n Disclosure<\/jats:title>\n K. Bebbington: None. D. Rudaizky: None. G.J. Smith: None. A.M. Hunt: None. E.A. Davis: None. T. Jones: Research Support; Self; Dexcom, Inc., Medtronic MiniMed, Inc. Speaker's Bureau; Self; Eli Lilly and Company, Roche Diabetes Care. A. Lin: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-203-or","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T02:00:56Z","timestamp":1559700056000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["203-OR: Characterizing Moment-to-Moment Fluctuations in Stress, Anxiety, and Blood Glucose Levels in Adolescents with Type 1 Diabetes"],"prefix":"10.2337","volume":"68","author":[{"given":"KEELY","family":"BEBBINGTON","sequence":"first","affiliation":[{"name":"Perth, Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DANIEL","family":"RUDAIZKY","sequence":"additional","affiliation":[{"name":"Perth, Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GRANT J.","family":"SMITH","sequence":"additional","affiliation":[{"name":"Perth, Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANNA M.","family":"HUNT","sequence":"additional","affiliation":[{"name":"Perth, Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH A.","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Perth, Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIMOTHY","family":"JONES","sequence":"additional","affiliation":[{"name":"Perth, Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ASHLEIGH","family":"LIN","sequence":"additional","affiliation":[{"name":"Perth, Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/203-OR\/55503\/203-OR-Characterizing-Moment-to-Moment","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/203-OR\/55503\/203-OR-Characterizing-Moment-to-Moment","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:33:36Z","timestamp":1647164016000},"score":7.6907096,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/203-OR\/55503\/203-OR-Characterizing-Moment-to-Moment"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-203-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"203-OR"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:41:19Z","timestamp":1753890079645,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Individualised approaches to diabetes management are essential so that an optimal balance is realised between the risk and benefits of treatment. In the elderly (E, 75-84 years) and extreme elderly (EE, \u2265 85 years) treatment adjustment is the cornerstone of management, in order to provide medicines that deliver efficacy, and to de-prescribe agents to limit iatrogenic adverse effects. To assess the opportunity to de-prescribe and better target prescribing, we performed a retrospective audit of 1,806 patients (E, n=1,649; EE, n=157). Data are presented as E and EE respectively. The majority had T2DM (99.1%), with long duration (median, IQR 13.9, 7.4-21.7; 17.5, 10.3-25.1 years); and were overweight (mean \u00b1 SD BMI 28.7 \u00b1 5.4; 27.0 \u00b1 4.5 kg\/m2). Over 50% used polypharmacy for glycaemic control; 37.9% and 40.8% used insulin +\/- tablets. 39.4% of E and 33.3% of EE achieved an HbA1c of &lt;7.0%, with HbA1c 7.5 \u00b11.4% and 7.8 \u00b1 1.6% (mean\u00b1 SD NGSP units). Over half (55.8%) of the EE group with an HbA1c &lt;7.0% were treated with insulin and\/or sulphonyureas, whereas only 38.2% of E were treated with these agents (p=0.01). While reported severe hypoglycaemia was uncommon (1.5% E and 2.8% EE), 35% of EE patients using insulin and\/or sulphonyureas experienced hypoglycaemia. Metformin had appropriately been ceased in all but 7 of the 63 patients with an eGFR &lt; 30 ml\/min\/1.73m2. While lipid profiles were favourable (HDL: 1.3 \u00b1 0.4 mmol\/L; LDL: 2.3 \u00b1 0.9 mmol\/L, Trig: 1.5, IQR: 1.1-2.1 mmol\/L and HDL: 1.3 \u00b1 0.3 mmol\/L; LDL: 2.3 \u00b1 1.0 mmol\/L, Trig: 1.5, IQR: 1.0-2.1 mmol\/L), lipid lowering therapy was used less frequently in EE (51.0%) versus E (62.6%) (p=0.004). Only 1 in 2 patients with known macrovascular disease were on anti-platelet treatment. This data demonstrates the potential over treatment of glycaemia in the EE specifically in hypoglycaemia inducing agents, highlighting the need to consider de-prescribing. Conversely, under-utilisation of evidence-based medication to address macrovascular risk is also evident.<\/jats:p>\n \n Disclosure<\/jats:title>\n S.A. Sharp: None. J. Overland: None. M. McGill: None. L.M. Molyneaux: None. T. Wu: Advisory Panel; Self; Boehringer Ingelheim International GmbH, Eli Lilly and Company, Novo Nordisk A\/S, Sanofi. Speaker's Bureau; Self; AstraZeneca, Boehringer Ingelheim International GmbH, Eli Lilly and Company, Merck Sharp & Dohme Corp., Novo Nordisk A\/S, Sanofi. S.M. Twigg: Advisory Panel; Self; Abbott, Boehringer Ingelheim Pharmaceuticals, Inc., Novo Nordisk Inc., Sanofi-Aventis. Board Member; Self; AstraZeneca. Research Support; Self; Abbott. Speaker's Bureau; Self; Abbott, AstraZeneca, Merck Sharp & Dohme Corp., Novo Nordisk Inc., Sanofi-Aventis. J. Wong: Advisory Panel; Self; Sanofi. Speaker's Bureau; Self; AstraZeneca, Lilly Diabetes.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-1455-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T01:11:56Z","timestamp":1559697116000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1455-P: Evaluating Opportunities for Deprescribing in the Elderly and Extreme Elderly with Diabetes"],"prefix":"10.2337","volume":"68","author":[{"given":"SABRINA A.","family":"SHARP","sequence":"first","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANE","family":"OVERLAND","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARGARET","family":"MCGILL","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"SR.","given":"LYNDA M.","family":"MOLYNEAUX","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TED","family":"WU","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN M.","family":"TWIGG","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENCIA","family":"WONG","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1455-P\/61389\/1455-P-Evaluating-Opportunities-for-Deprescribing","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1455-P\/61389\/1455-P-Evaluating-Opportunities-for-Deprescribing","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T11:17:36Z","timestamp":1647170256000},"score":7.6907096,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1455-P\/61389\/1455-P-Evaluating-Opportunities-for-Deprescribing"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-1455-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"1455-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:26:36Z","timestamp":1753878396445,"version":"3.41.2"},"reference-count":0,"publisher":"Wiley","issue":"S284","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,1]]},"abstract":"Aims\/Purpose:<\/jats:bold> Improvements in technology for head mounted displays allow both a large increase in the quantity of visual information presented and capacity to control how it is displayed. The requirements of defence operators are unique, including making quick and efficient decisions, operating in varying light conditions and using night vision devices and laser eye protection. Scientifically\u2010informed symbology is required to ensure maximal operational capacity is obtained from available technology.<\/jats:p>Methods:<\/jats:bold> Applied tasks have been used to investigate the addition of colour to visual symbology. The first used a flight simulator to examine the effect of adding colour to symbology requiring attention; both day and night backgrounds were investigated with the plane on autopilot. Participants were required to identify randomly appearing symbols presented either as monochrome green or with additional colour, in addition to other tasks. The second task manipulated symbology colour to improve performance when using laser eye protection. Participants undertook two simulated drives wearing laser eye protection while responding to both standard and optimised coloured symbols.<\/jats:p>Results:<\/jats:bold> For the flight simulator experiment, the use of colour to draw attention to symbology resulted in faster response times (1.81s vs 2.57s, p <<\/jats:italic> 0.001) and fewer missed events (0.91 vs 3.32\/15 missed, p <<\/jats:italic> 0.001). For the driving experiment, manipulating the colours did not statistically significantly affect reaction time but resulted in a statistically significant improvement in the accuracy of symbol detection and identification (standard 88.7%, optimised 94.5%, p <<\/jats:italic> 0.001).<\/jats:p>Conclusion:<\/jats:bold> The judicious use of colour informed by vision science in displays has demonstrated improvements in reaction time and accuracy which may be operationally significant for defence operators. Further work is required to refine other salient aspects of symbology which may attract attention including size, luminance and flicker.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.16844","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:37:21Z","timestamp":1737333441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vision science informing visual display symbology"],"prefix":"10.1111","volume":"103","author":[{"given":"Amanda","family":"Douglass","sequence":"first","affiliation":[{"name":"Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Coffey","sequence":"additional","affiliation":[{"name":"Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeline","family":"Baker","sequence":"additional","affiliation":[{"name":"Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee","family":"Karas","sequence":"additional","affiliation":[{"name":"Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Francis","sequence":"additional","affiliation":[{"name":"Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Abel","sequence":"additional","affiliation":[{"name":"Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Gavrilescu","sequence":"additional","affiliation":[{"name":"Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,19]]},"container-title":["Acta Ophthalmologica"],"language":"en","deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T07:49:26Z","timestamp":1741765766000},"score":7.6906724,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.16844"}},"issued":{"date-parts":[[2025,1]]},"references-count":0,"journal-issue":{"issue":"S284","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/aos.16844"],"URL":"https:\/\/doi.org\/10.1111\/aos.16844","archive":["Portico"],"ISSN":["1755-375X","1755-3768"],"issn-type":[{"type":"print","value":"1755-375X"},{"type":"electronic","value":"1755-3768"}],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"aos.16844"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:33Z","timestamp":1753889793556,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,6,14]]},"abstract":"Introduction & Objective: Emerging evidence suggests cell exfoliation could be operating under the control of cell metabolism. Recent studies indicate kidney cell exfoliation into urine may reflect metabolic status. Proximal tubule cell (PTC) exfoliation can be particularly sensitive to hyperglycemia in diabetes mellitus (DM) as glucose entry into PTCs is insulin independent. While it appears that number of urinary exfoliated PTCs increases with DM, it is unclear if there are associations between number of exfoliated PTCs with diabetic severity and co-morbidities. Our study aims to explore this.<\/jats:p>\n Methods: Adults age \u2265 18 yrs with type 1 or 2 DM were included. Collected urine samples were stored at -80\u00b0C. On assessment, exfoliated PTCs were extracted from thawed urine using a validated specific immunomagnetic separation method based on anti CD13 and anti SGLT2 antibodies. Number of PTCs present was visualized using brightfield microscopy. A Poisson regression model adjusting for HbA1c%, eGFR (ml\/min\/1.73m2), presence of diabetic retinopathy (DR), cardiovascular events (CVE) history, age (yrs), sex, ethnicity, BMI, urine volume (ml) collected, estimated urinary creatinine clearance rate, serum creatinine, uACR and blood pressure (mmHg) as variables was constructed to determine association with mean exfoliated PTCs. Incidence rate ratios (IRR) determined significance of association.<\/jats:p>\n Results: Eighty four patients with DM were included. Mean age is 63.8 yrs (std dev 11.6) and 81% are male. Each 1% increase in HbA1c% was associated with an increase of 1.03 times in mean exfoliated PTCs (IRR 1.03, 95%CI 1.01-1.04, p=0.007). Presence of DR was associated with an increase of 1.68 times in mean exfoliated PTCs (IRR 1.68, 95%CI 1.07-2.62, p=0.024). There were no significant associations between eGFR or CVE history with mean exfoliated PTCs.<\/jats:p>\n Conclusion: Our results indicate increased shedding of PTCs into the urinary tract in patients with DM with poorer glycemic control and presence of DR.<\/jats:p>\n \n Disclosure<\/jats:title>\n H. Wu: None. L. Nguyen: None. V. Bhagavath: None. E. Goldys: None. C. Pollock: Advisory Panel; AstraZeneca, Vifor Pharma Management Ltd. Speaker's Bureau; Eli Lilly and Company, Boehringer-Ingelheim, Novartis AG, Janssen Scientific Affairs, LLC, Otsuka America Pharmaceutical, Inc., AstraZeneca, Vifor Pharma Management Ltd., Merck Sharp & Dohme Corp. S. Saad: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db24-499-p","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T06:20:15Z","timestamp":1718346015000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["499-P: Association between Diabetic Retinopathy and Number of Urinary Exfoliated Proximal Tubule Kidney Cells"],"prefix":"10.2337","volume":"73","author":[{"given":"HENRY","family":"HL WU","sequence":"first","affiliation":[{"name":"St. Leonards, Sydney, Australia, Kensington, Sydney, Australia, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LONG","family":"THE NGUYEN","sequence":"additional","affiliation":[{"name":"St. Leonards, Sydney, Australia, Kensington, Sydney, Australia, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VENKATESHA","family":"BHAGAVATH","sequence":"additional","affiliation":[{"name":"St. Leonards, Sydney, Australia, Kensington, Sydney, Australia, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EWA","family":"GOLDYS","sequence":"additional","affiliation":[{"name":"St. Leonards, Sydney, Australia, Kensington, Sydney, Australia, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CAROL","family":"POLLOCK","sequence":"additional","affiliation":[{"name":"St. Leonards, Sydney, Australia, Kensington, Sydney, Australia, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SONIA","family":"SAAD","sequence":"additional","affiliation":[{"name":"St. Leonards, Sydney, Australia, Kensington, Sydney, Australia, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/499-P\/155887\/499-P-Association-between-Diabetic-Retinopathy-and","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/499-P\/155887\/499-P-Association-between-Diabetic-Retinopathy-and","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T06:20:15Z","timestamp":1718346015000},"score":7.690433,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/499-P\/155887\/499-P-Association-between-Diabetic-Retinopathy-and"}},"issued":{"date-parts":[[2024,6,14]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2024,6,14]]}},"URL":"https:\/\/doi.org\/10.2337\/db24-499-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2024,6,14]]},"article-number":"499-P"},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:43:05Z","timestamp":1651210985465},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.juro.2018.02.1276","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T12:35:19Z","timestamp":1522758919000},"source":"Crossref","is-referenced-by-count":0,"title":["MP40-09 MOVING TOWARDS ZERO SEPSIS; OUR REGISTRARS CAN DO IT! AN ANALYSIS OF 214 CASES OF TRANSPERINEAL PROSTATE BIOPSY OVER THREE YEARS"],"prefix":"10.1097","volume":"199","author":[{"given":"Hansi","family":"Pathirana","sequence":"first","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Kam","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuigi","family":"Yuminaga","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieran","family":"Beattie","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunny","family":"Nalavenkata","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan","family":"Arianayagam","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertram","family":"Canagasingham","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Ko","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celi","family":"Varol","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Winter","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Khadra","sequence":"additional","affiliation":[{"name":"Kingswood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534718405861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534718405861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2018.02.1276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:15:54Z","timestamp":1651209354000},"score":7.6903005,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2018.02.1276"}},"issued":{"date-parts":[[2018,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1016\/j.juro.2018.02.1276"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2018.02.1276","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2018,4]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:35:44Z","timestamp":1753889744877,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"High dementia prevalence and associated disability have necessitated a focus on the identification of potentially modifiable risk factors. One such example is type 2 diabetes; however, there are not enough large population-based studies that can provide an accurate estimate of the strength of the association. Therefore, we investigated prospective associations between diabetes and dementia using Australian national registries. The study included ~850,000 people with type 2 diabetes (median age=66.2 years, females=45.5%) registered on the National Diabetes Services Scheme (NDSS) during the period 2002-2014 and followed up for at least 1 year (median 7.0 years). Propensity score matching (based on logistic regression with birth year, sex, socio-economic index and medication history as predictors) was then conducted to match (1:1) people with diabetes to a general population control group without diabetes. The latter comprised people with no registration history on NDSS or record of taking glucose lowering drugs on the Pharmaceutical Benefits Scheme (median age=67.3 years, females=43.9%, median follow up=7.5 years). Dementia was defined either by dementia drug use (cholinesterase inhibitors or memantine) or dementia-related death. The association between diabetes and dementia was examined using Cox\u2019s proportional hazard model that treated each individual with diabetes and their matched control as one stratum. Diabetes was associated with an increased risk of dementia-related death (HR 1.19, 95% CI 1.17, 1.22), while no significant association was observed between diabetes and dementia medication use (HR 0.99, 95% CI 0.97, 1.02). When both dementia-related death and dementia drug use were included in the outcome, diabetes was still associated with an increased risk of dementia (HR 1.11, 95% CI 1.09, 1.14). These findings highlight the need for clinicians to be vigilant in identifying and managing diabetes as a potentially modifiable risk factor for cognitive decline and dementia.<\/jats:p>\n \n Disclosure<\/jats:title>\n K.Mehta: None. A.Salim: None. J.W.Sacre: None. K.J.Anstey: Speaker's Bureau; Nutricia. D.J.Magliano: None. J.E.Shaw: Advisory Panel; Abbott Diagnostics, Lilly, Zuellig Pharma Holdings Pte. Ltd., Mylan, Research Support; AstraZeneca, Speaker's Bureau; AstraZeneca, Roche Diagnostics, Lilly, Amgen Inc., Sanofi, Zuellig Pharma Holdings Pte. Ltd.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Deakin University (to K.M.); Alicia Baker and Eleanor Shaw Gender Equity Fellowship (to D.J.M.); National Health and Medical Research Council (APP1173952 to J.E.S.); Victorian Government\u2019s Operational Infrastructure Support Program<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-1318-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:33:17Z","timestamp":1687242797000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1318-P: Type 2 Diabetes as a Risk Factor for Dementia\u2014An Analysis of Australian National Registries"],"prefix":"10.2337","volume":"72","author":[{"given":"KANIKA","family":"MEHTA","sequence":"first","affiliation":[{"name":"Randwick, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AGUS","family":"SALIM","sequence":"additional","affiliation":[{"name":"Randwick, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JULIAN W.","family":"SACRE","sequence":"additional","affiliation":[{"name":"Randwick, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAARIN J.","family":"ANSTEY","sequence":"additional","affiliation":[{"name":"Randwick, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DIANNA J.","family":"MAGLIANO","sequence":"additional","affiliation":[{"name":"Randwick, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JONATHAN E.","family":"SHAW","sequence":"additional","affiliation":[{"name":"Randwick, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1318-P\/150844\/1318-P-Type-2-Diabetes-as-a-Risk-Factor-for","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1318-P\/150844\/1318-P-Type-2-Diabetes-as-a-Risk-Factor-for","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:33:18Z","timestamp":1687242798000},"score":7.6903005,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1318-P\/150844\/1318-P-Type-2-Diabetes-as-a-Risk-Factor-for"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-1318-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"1318-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:27Z","timestamp":1753889787314,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: Survodutide (Survo) is a therapy undergoing Phase III studies to investigate its suitability for treating people living with obesity and MASH. Survo is a dual agonist that increases energy expenditure and decreases energy intake via activation of Glucagon Receptor (GCGR) and GLP-1 Receptor (GLP-1R), respectively, leading to up to 19% weight-loss, and 64.5% fibrosis reduction in F2-F3. We investigated the molecular basis of Survo\u2019s dual agonism and how this differs from other GCGR and GLP-1R agonists.<\/jats:p>\n Methods: We employed in vitro assays such as cyclic adenosine mono phosphate (cAMP) production to compare Survo to the endogenous peptides GLP-1, glucagon (GCG), and oxyntomodulin (Oxy). Cryogenic electron microscopy (cryo-EM) structures of GCGR and GLP-1R in complex with Survo and G protein were determined at high resolution.<\/jats:p>\n Results: Survo is a 29 amino acid (AA) peptide based on GCG with pos 18, 20 and 23 swapped to GLP-1 and pos 16 swapped to exendin-4. Pos 24 and 27-29 were changed to other AA\u2019s and pos 2 to the novel unnatural AA Ac4c. Survo induces cAMP production 4-fold less potent compared to native GLP-1 at GLP-1R (EC50: 20 vs 5 pM, respectively) and 22-times less potent compared to native GCG at GCGR (EC50: 108 vs 5 pM for Survo and GCG, respectively) while resembling the dual agonist Oxy at both receptors (EC50: 36 and 47 pM at GLP-1R and GCGR, respectively). Cryo-EM structures show similar binding poses for Survo compared to other peptide agonists, with differential AA\u2019s showing interactions that explain the assay data. The lysine side chain at pos 24 links to a fatty diacid to improve plasma half-life. Removal of the linker and diacid increased potency at both receptors (EC50: 2 and 23 pM at GLP-1R and GCGR, respectively) with subtle changes in cryo-EM structures.<\/jats:p>\n Conclusion: The activation profile of Survo at GCGR and GLP-1R can be rationalized by structural evidence and the gained knowledge will inform therapeutic approaches in both obesity and MASH targeted treatment regimes. We further give insight into the effect of peptide lipidation.<\/jats:p>\n \n Disclosure<\/jats:title>\n E. Yuliantie: None. P.N.H. Trinh: None. F. Bumbak: None. X. Zhang: None. Y. Jiang: None. Q. Ou: None. R. Ebenhoch: Employee; Boehringer-Ingelheim. D. Weichert: Employee; Boehringer-Ingelheim. H. Nar: Employee; Boehringer-Ingelheim. P.M. Sexton: Research Support; AstraZeneca, Pfizer Inc, Boehringer-Ingelheim, Novo Nordisk A\/S, Astex Pharmaceuticals. D. Wootten: Research Support; Novo Nordisk A\/S, Boehringer-Ingelheim, Pfizer Inc. Stock\/Shareholder; Septerna Inc, Dacra Therapeutics. Research Support; AstraZeneca.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-1974-lb","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:22:09Z","timestamp":1749792129000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1974-LB: The Molecular Basis of Survodutide (BI456906) Glucagon\/GLP-1 Receptor Dual Agonism"],"prefix":"10.2337","volume":"74","author":[{"given":"ELITA","family":"YULIANTIE","sequence":"first","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia, Biberach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PHUC N.H.","family":"TRINH","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia, Biberach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FABIAN","family":"BUMBAK","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia, Biberach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIN","family":"ZHANG","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia, Biberach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YE","family":"JIANG","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia, Biberach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"QINGHAO","family":"OU","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia, Biberach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"REBECCA","family":"EBENHOCH","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia, Biberach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DIETMAR","family":"WEICHERT","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia, Biberach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HERBERT","family":"NAR","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia, Biberach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PATRICK M.","family":"SEXTON","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia, Biberach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DENISE","family":"WOOTTEN","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia, Biberach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1974-LB\/158760\/1974-LB-The-Molecular-Basis-of-Survodutide","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1974-LB\/158760\/1974-LB-The-Molecular-Basis-of-Survodutide","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T15:52:01Z","timestamp":1750434721000},"score":7.6899805,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1974-LB\/158760\/1974-LB-The-Molecular-Basis-of-Survodutide"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-1974-lb","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"1974-LB"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:35Z","timestamp":1753889855643,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"Background: Hybrid closed loop (HCL) systems are evolving. We aimed to assess treatment satisfaction and glucose control with an investigational eAHCL system.<\/jats:p>\n Methods: Adults with type 1 diabetes (T1D) received sequentially the MiniMed\u2122 780G \/Guardian\u2122 Sensor 3 AHCL system, and a Medtronic investigational eAHCL system each for 12 weeks. The eAHCL system incorporates updated software, a new simple to use, no calibration, all-in-one sensor, and 7 day extended wear infusion set. The primary outcome was difference in treatment satisfaction measured using \u201ccurrent\u201d and \u201cchange\u201d versions of the Diabetes Technology Questionnaire (DTQ) following each 12 week period. Secondary outcomes included time spent changing infusion sets and sensors recorded on a phone app and CGM metrics.<\/jats:p>\n Results: Twenty-one adults (11 men, mean [SD] age 48 [12.4] years) completed the trial. DTQ \u201ccurrent\u201d score improved on eAHCL, and 86% of participants reported less \u201cEffort to keep low blood sugar from happening\u201d on DTQ \u201cchange\u201d. There was less fear of hypoglycemia; more time in Auto Mode; fewer alarms; less time spent changing infusion sets and sensors; reduced CGM hypoglycemia and glycemic variability (Table 1).<\/jats:p>\n Conclusions: Transition to eAHCL in T1D adults resulted in a better user experience and reduced fear of and time in hypoglycemia while maintaining safety and &gt;80% TIR.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n C.Yuan: None. R.Macisaac: None. E.Netzer: None. B.Paldus: None. L.Robinson: None. A.Roy: Employee; Medtronic. C.M.Sims: Stock\/Shareholder; Medtronic. S.Trawley: Research Support; Insulet Corporation, Juvenile Diabetes Research Foundation (JDRF). S.Vogrin: None. D.N.O'neal: None. Y.W.Kong: None. T.Amoore: None. K.Brown: None. B.Grosman: Employee; Medtronic. A.Jenkins: Advisory Panel; Insulet Corporation, Board Member; Insulin for Life, Research Support; Abbott Diabetes, Medtronic, Hemsley Charitable Trust, Juvenile Diabetes Research Foundation (JDRF), National Institutes of Health. H.Jones: None. N.Kurtz: Employee; Medtronic. M.H.Lee: Speaker's Bureau; Medtronic.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-922-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:45:47Z","timestamp":1687239947000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["922-P: Improved Satisfaction while Maintaining Safety and High Time in Range (TIR) with a Medtronic Investigational Enhanced Advanced Hybrid Closed-Loop System (eAHCL)"],"prefix":"10.2337","volume":"72","author":[{"given":"CHENG","family":"YI YUAN","sequence":"first","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YEE W.","family":"KONG","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TESS","family":"AMOORE","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATRIN","family":"BROWN","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BENYAMIN","family":"GROSMAN","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HANNAH","family":"JONES","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NATALIE","family":"KURTZ","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MELISSA H.","family":"LEE","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"MACISAAC","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EMMA","family":"NETZER","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BARBORA","family":"PALDUS","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LESLEY","family":"ROBINSON","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANIRBAN","family":"ROY","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CATRIONA M.","family":"SIMS","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEVEN","family":"TRAWLEY","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SARA","family":"VOGRIN","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Northridge, CA, Sydney, Australia, Agoura Hills, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/922-P\/150018\/922-P-Improved-Satisfaction-while-Maintaining","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/922-P\/150018\/922-P-Improved-Satisfaction-while-Maintaining","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:45:47Z","timestamp":1687239947000},"score":7.689526,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/922-P\/150018\/922-P-Improved-Satisfaction-while-Maintaining"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-922-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"922-P"},{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:03:21Z","timestamp":1770228201739,"version":"3.49.0"},"reference-count":7,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["FLF106656"],"award-info":[{"award-number":["FLF106656"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2024,10]]},"abstract":"Abstract<\/jats:title>Pushing selected information to clinicians, as opposed to the traditional method of clinicians pulling information from an electronic medical record, has the potential to improve care. A digital notification platform was designed by clinicians and implemented in a tertiary hospital to flag dysglycaemia. There were 112 patients included in the study, and the post\u2010implementation group demonstrated lower rates of dysglycaemia (2.5% vs 1.1%, P<\/jats:italic> =\u20090.038). These findings raise considerations for information delivery methods for multiple domains in contemporary healthcare.<\/jats:p>","DOI":"10.1111\/imj.16506","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T05:20:00Z","timestamp":1725427200000},"page":"1753-1756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Push or pull? Digital notification platform implementation reduces dysglycaemia"],"prefix":"10.1111","volume":"54","author":[{"given":"Shrirajh","family":"Satheakeerthy","sequence":"first","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"SA Health Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-3489","authenticated-orcid":false,"given":"Brandon","family":"Stretton","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"SA Health Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew E. C.","family":"Booth","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"SA Health Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Howson","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"SA Health Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun","family":"Evans","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"SA Health Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3880-3840","authenticated-orcid":false,"given":"Joshua","family":"Kovoor","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Ballarat Base Hospital Ballarat Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"McNeil","sequence":"additional","affiliation":[{"name":"Commission on Excellence and Innovation in Health Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7652-4378","authenticated-orcid":false,"given":"Ashley","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Zeitz","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"SA Health Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alasdair","family":"Leslie","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Psaltis","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aashray","family":"Gupta","sequence":"additional","affiliation":[{"name":"Royal North Shore Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8310-0853","authenticated-orcid":false,"given":"Sheryn","family":"Tan","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Teo","sequence":"additional","affiliation":[{"name":"SA Health Adelaide South Australia Australia"},{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Vanlint","sequence":"additional","affiliation":[{"name":"SA Health Adelaide South Australia Australia"},{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weng O.","family":"Chan","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"SA Health Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-6167","authenticated-orcid":false,"given":"Andrew","family":"Zannettino","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0635-1894","authenticated-orcid":false,"given":"Patrick G.","family":"O'Callaghan","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Maddison","sequence":"additional","affiliation":[{"name":"SA Health Adelaide South Australia Australia"},{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Gluck","sequence":"additional","affiliation":[{"name":"SA Health Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3431-9672","authenticated-orcid":false,"given":"Toby","family":"Gilbert","sequence":"additional","affiliation":[{"name":"SA Health Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5130-8628","authenticated-orcid":false,"given":"Stephen","family":"Bacchi","sequence":"additional","affiliation":[{"name":"SA Health Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-1524-0_2"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16266"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.109-5644"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.4236\/wjcd.2013.32038"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-020-01374-0"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16308"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16160"}],"container-title":["Internal Medicine Journal"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.16506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T15:28:33Z","timestamp":1727882913000},"score":7.6885753,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.16506"}},"issued":{"date-parts":[[2024,9,3]]},"references-count":7,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/imj.16506"],"URL":"https:\/\/doi.org\/10.1111\/imj.16506","archive":["Portico"],"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"published":{"date-parts":[[2024,9,3]]},"assertion":[{"value":"2024-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:33:48Z","timestamp":1780587228918,"version":"3.54.1"},"reference-count":20,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Health and Medical Research Council, Australia"},{"name":"New South Wales Office of Science and Medical Research, Australia"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2015,12]]},"abstract":"\n Background<\/jats:title>\n More effective and efficient rehabilitation is urgently needed to address the prevalence of unmet rehabilitation needs after stroke. This study compared the efficacy of two poststroke upper limb therapy protocols.<\/jats:p>\n <\/jats:sec>\n \n Aims and\/or hypothesis<\/jats:title>\n We tested the hypothesis that Wii-based movement therapy would be as effective as modified constraint-induced movement therapy for post-stroke upper-limb motor rehabilitation.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Forty-one patients, 2\u201346 months poststroke, completed a 14-day program of Wii-based Movement Therapy or modified Constraint-induced Movement Therapy in a dose-matched, assessor-blinded randomized controlled trial, conducted in a research institute or patient's homes. Primary outcome measures were the Wolf Motor Function Test timed-tasks and Motor Activity Log Quality of Movement scale. Patients were assessed at prebaseline (14 days pretherapy), baseline, post-therapy, and six-month follow-up. Data were analyzed using linear mixed models and repeated measures analysis of variance.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were no differences between groups for either primary outcome at any time point. Motor function was stable between prebaseline and baseline (\n P<\/jats:italic>\n > 0\u00b705), improved with therapy (\n P<\/jats:italic>\n < 0\u00b7001); and improvements were maintained at six-months (\n P<\/jats:italic>\n > 0\u00b705). Wolf Motor Function Test timed-tasks log times improved from 2\u00b71 \u00b1 0\u00b722 to 1\u00b77 \u00b1 0\u00b722 s after Wii-based Movement Therapy, and 2\u00b76 \u00b1 0\u00b723 to 2\u00b73 \u00b1 0\u00b724 s after modified Constraint-induced Movement Therapy. Motor Activity Log Quality of Movement scale scores improved from 67\u00b77 \u00b1 6\u00b707 to 102\u00b74 \u00b1 6\u00b748 after Wii-based Movement Therapy and 64\u00b71 \u00b1 7\u00b730 to 93\u00b70 \u00b1 5\u00b795 after modified Constraint-induced Movement Therapy (mean \u00b1 standard error of the mean). Patient preference, acceptance, and continued engagement were higher for Wii-based Movement Therapy than modified Constraint-induced Movement Therapy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study demonstrates that Wii-based Movement Therapy is an effective upper limb rehabilitation poststroke with high patient compliance. It is as effective as modified Constraint-induced Movement Therapy for improving more affected upper limb movement and increased independence in activities of daily living.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijs.12594","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T14:07:08Z","timestamp":1441202828000},"page":"1253-1260","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":61,"title":["The Efficacy of Wii-Based Movement Therapy for Upper Limb Rehabilitation in the Chronic Poststroke Period: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"10","author":[{"given":"Penelope A.","family":"McNulty","sequence":"first","affiliation":[{"name":"Neuroscience Research Australia, Sydney, NSW, Australia"},{"name":"UNSW Australia, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica G.","family":"Thompson-Butel","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Sydney, NSW, Australia"},{"name":"UNSW Australia, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Faux","sequence":"additional","affiliation":[{"name":"UNSW Australia, Sydney, NSW, Australia"},{"name":"St Vincent's Hospital, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaven","family":"Lin","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pesi H.","family":"Katrak","sequence":"additional","affiliation":[{"name":"UNSW Australia, Sydney, NSW, Australia"},{"name":"Prince of Wales Hospital, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura R.","family":"Harris","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Sydney, NSW, Australia"},{"name":"UNSW Australia, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine T.","family":"Shiner","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Sydney, NSW, Australia"},{"name":"UNSW Australia, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,9]]},"reference":[{"key":"e_1_3_2_2_1","volume-title":"Australia's Health 2014","author":"AIHW.","year":"2014","unstructured":"1 AIHW. Australia's Health 2014. Canberra, Australian Institute of Health and Welfare, 2014."},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12325"},{"key":"e_1_3_2_4_1","volume-title":"The Economic Impact of Stroke on Australia","author":"Deloitte Access Economics","year":"2013","unstructured":"3 Deloitte Access Economics. The Economic Impact of Stroke on Australia. Melbourne, National Stroke Foundation, 2013."},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-2007-00380"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.17.2095"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000206463.66461.97"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1191\/0269215502cr473oa"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20060029"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000559"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20060355"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0816"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.584979"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0528"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1108\/SCN-04-2013-0018"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/g4h.2012.0055"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968314523678"},{"key":"e_1_3_2_18_1","first-page":"347","article-title":"Technique to improve chronic motor deficit after stroke","volume":"74","author":"Taub E","year":"1993","unstructured":"17 Taub E, Miller NE, Novack TA, . Technique to improve chronic motor deficit after stroke. Arch Phys Med Rehabil 1993; 74:347\u201354.","journal-title":"Arch Phys Med Rehabil"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1901\/jeab.1994.61-281"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2007.891388"},{"key":"e_1_3_2_21_1","volume-title":"National Stroke Audit Rehabilitation Services Report","author":"NSF.","year":"2012","unstructured":"20 NSF. National Stroke Audit Rehabilitation Services Report. Melbourne, National Stroke Foundation, 2012."}],"container-title":["International Journal of Stroke"],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijs.12594","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1111\/ijs.12594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1111\/ijs.12594","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1111\/ijs.12594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T04:40:53Z","timestamp":1767674453000},"score":7.688266,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1111\/ijs.12594"}},"issued":{"date-parts":[[2015,9]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/ijs.12594"],"URL":"https:\/\/doi.org\/10.1111\/ijs.12594","ISSN":["1747-4930","1747-4949"],"issn-type":[{"value":"1747-4930","type":"print"},{"value":"1747-4949","type":"electronic"}],"published":{"date-parts":[[2015,9]]}},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T04:41:46Z","timestamp":1651207306326},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.juro.2015.02.1364","type":"journal-article","created":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T04:54:37Z","timestamp":1427777677000},"source":"Crossref","is-referenced-by-count":0,"title":["MP31-09 THE EFFECTS OF CURRENTLY USED ANTI-HYPERTENSIVES ON THE CONTRACTILITY OF THE HUMAN PROSTATE GLAND"],"prefix":"10.1097","volume":"193","author":[{"given":"Betty","family":"Exintaris","sequence":"first","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basu","family":"Chakrabarty","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad","family":"Wittmer","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Papargiris","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Frydenberg","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Lawrentschuk","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Nottle","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Ryan","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Norden","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Risbridger","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534715016754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534715016754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2015.02.1364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T04:25:22Z","timestamp":1651206322000},"score":7.6881537,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2015.02.1364"}},"issued":{"date-parts":[[2015,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1016\/j.juro.2015.02.1364"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2015.02.1364","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2015,4]]}},{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:02:39Z","timestamp":1767841359313,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"S6","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Alzheimer's disease (AD), the most common form of dementia, is marked by significant reductions in glucose metabolism. Such hypometabolism reflects underlying synaptic dysfunction, correlating with cognitive decline. Our study aimed to explore the impact of dietary patterns\u2014specifically, the Western Diet and Prudent Diet\u2014on change in glucose metabolism in brain regions associated with AD risk, [\n 18<\/jats:sup>\n F]Fluorodeoxyglucose positron emission tomography (FDG\u2010PET) imaging as a biomarker.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n Longitudinal data from 133 cognitively unimpaired older adults were analysed from the Western Australian Memory Study. Participants underwent dietary assessment using the Cancer Council of Victoria Food Frequency Questionnaire and completed FDG\u2010PET imaging up to three times over 43 months. Dietary patterns were identified through principal component analysis, yielding two patterns\u2014named Western Diet and Prudent Diet. Pattern scores were computed by summing food group intakes weighted by their respective factor loadings. Linear mixed\u2010effect models evaluated the association between dietary adherence and brain glucose metabolism, including potential confounders. The cohort was stratified by apolipoprotein E (\n APOE)<\/jats:italic>\n \u03b54 carrier status, a genetic risk factor for AD, to investigate potential differing effects.\n <\/jats:p>\n <\/jats:sec>\n \n Result<\/jats:title>\n \n Adherence to a Western Diet, characterised by high sugars and saturated fats, was associated with a faster decline in glucose metabolism in the right fusiform gyrus among\n APOE<\/jats:italic>\n \u03b54 carriers (\u03b2\u00a0=\u00a0\u20100.00012; SE\u00a0=\u00a00.00004; false discover rate adjusted\n p<\/jats:italic>\n \u00a0=\u00a0.032), with no significant associations in\n APOE<\/jats:italic>\n \u03b54 non\u2010carriers. Similarly, no significant associations were observed between the Prudent Diet, characterised by high intake of fruits, vegetables, and whole grains, and glucose metabolism, in both\n APOE<\/jats:italic>\n \u03b54 carriers and non\u2010carriers.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our study highlights the potential detrimental impact of a Western Diet on brain glucose metabolism, particularly for individuals at genetic risk for AD. The decline in glucose metabolism in the fusiform gyrus, a region essential for cognitive functions like facial recognition, emphasises the role of diet in brain health. Future research should examine the mechanisms linking diet to neurodegeneration and explore dietary interventions as preventive strategies against cognitive decline and dementia.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz70860_100615","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T19:40:48Z","timestamp":1766518848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Patterns and Cerebral Glucose Metabolism in Older Adults: Findings from the Western Australia Memory Study"],"prefix":"10.1002","volume":"21","author":[{"given":"Carolina B","family":"Castro","sequence":"first","affiliation":[{"name":"Murdoch University, Murdoch, Western Australia, Australia"},{"name":"Alzheimer's Research Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha L","family":"Gardener","sequence":"additional","affiliation":[{"name":"Alzheimer's Research Australia, Perth, Western Australia, Australia"},{"name":"Edith Cowan University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzana","family":"Jahan","sequence":"additional","affiliation":[{"name":"Murdoch University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Chen","sequence":"additional","affiliation":[{"name":"The University of Sydney, Sydney, NSW, Australia"},{"name":"Macquarie University, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Murdoch University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruey","family":"Loo","sequence":"additional","affiliation":[{"name":"Murdoch University, PERTH, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Taddei","sequence":"additional","affiliation":[{"name":"Alzheimer's Research Australia, Perth, Western Australia, Australia"},{"name":"Edith Cowan University, Joondalup, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie R","family":"Rainey\u2010Smith","sequence":"additional","affiliation":[{"name":"Murdoch University, Perth, Western Australia, Australia"},{"name":"Alzheimer's Research Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Weinborn","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Caroline R.","family":"dos Reis","sequence":"additional","affiliation":[{"name":"State of Bahia University, Salvador, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph N","family":"Martins","sequence":"additional","affiliation":[{"name":"Alzheimer's Research Australia, Perth, Western Australia, Australia"},{"name":"Macquarie University, Sydney, NSW, Australia"},{"name":"School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid R","family":"Sohrabi","sequence":"additional","affiliation":[{"name":"Murdoch University, Murdoch, Western Australia, Australia"},{"name":"Alzheimer's Research Australia, Perth, Western Australia, Australia"},{"name":"Edith Cowan University, Perth, Western Australia, Australia"},{"name":"School of Psychology, Murdoch University, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,23]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz70860_100615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T21:52:27Z","timestamp":1767822747000},"score":7.6873937,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz70860_100615"}},"issued":{"date-parts":[[2025,12]]},"references-count":0,"journal-issue":{"issue":"S6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/alz70860_100615"],"URL":"https:\/\/doi.org\/10.1002\/alz70860_100615","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e100615"},{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:03:57Z","timestamp":1778637837318,"version":"3.51.4"},"reference-count":17,"publisher":"CSIRO Publishing","issue":"2","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":1113,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2022,5,13]]},"abstract":"NDI Carrara 1 is a deep stratigraphic well completed in 2020 as part of the MinEx CRC National Drilling Initiative (NDI), in collaboration with Geoscience Australia and the Northern Territory Geological Survey. It is the first stratigraphic test of the Carrara Sub-basin, a newly discovered depocentre in the South Nicholson Region. The well intersected Proterozoic sediments with numerous hydrocarbon shows, likely to be of particular interest due to affinities with the known Proterozoic plays of the Beetaloo Sub-basin and the Lawn Hill Platform, including two organic-rich black shales and a thick sequence of interbedded black shales and silty-sandstones. Alongside an extensive suite of wireline logs, continuous core was recovered from 283.9\u2009m to total depth at 1750.8\u2009m, providing high-quality data to support comprehensive analysis. Presently, this includes geochronology, geochemistry, geomechanics and petrophysics. Rock-Eval pyrolysis data demonstrate the potential for several thick black shales to be a source of hydrocarbons for conventional and unconventional plays. Integration of these data with geomechanical properties highlights potential brittle zones within the fine-grained intervals where hydraulic stimulation is likely to enhance permeability, identifying prospective Carrara Sub-basin shale gas intervals. Detailed wireline log analysis further supports a high potential for unconventional shale resources. Interpretation of the L210 and L212 seismic surveys suggests that the intersected sequences are laterally extensive and continuous throughout the Carrara Sub-basin, potentially forming a significant new hydrocarbon province and continuing the Proterozoic shale play fairway across the Northern Territory and northwest Queensland.<\/jats:p>","DOI":"10.1071\/aj21075","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T19:36:52Z","timestamp":1652384212000},"page":"S378-S384","source":"Crossref","is-referenced-by-count":2,"title":["Resource potential of the Carrara Sub-basin from the deep stratigraphic well NDI Carrara 1"],"prefix":"10.1071","volume":"62","author":[{"given":"A. H. E.","family":"Bailey","sequence":"first","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Grosjean","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Wang","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Boreham","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Butcher","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Carson","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J. M.","family":"Jarrett","sequence":"additional","affiliation":[{"name":"BNorthern Territory Geological Survey, Darwin, NT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. K.","family":"Carr","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Southby","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. J.","family":"Palu","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A.","family":"Henson","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2022,5,13]]},"reference":[{"key":"2025122722194478000_R1"},{"key":"2025122722194478000_R2"},{"key":"2025122722194478000_R3"},{"key":"2025122722194478000_R4"},{"key":"2025122722194478000_R5"},{"issue":"3","key":"2025122722194478000_R6","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3997\/1365-2397.2011042","article-title":"Estimation of stress and geomechanical properties using 3D seismic data.","volume":"30","author":"Gray","year":"2012","journal-title":"First Break"},{"key":"2025122722194478000_R7"},{"key":"2025122722194478000_R8"},{"key":"2025122722194478000_R9"},{"key":"2025122722194478000_R10"},{"key":"2025122722194478000_R11","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1306\/12190606068","article-title":"Unconventional shale-gas systems: the Mississippian Barnett Shale of north-central Texas as one model for thermogenic shale-gas assessment.","volume":"91","author":"Jarvie","year":"2007","journal-title":"AAPG Bulletin"},{"key":"2025122722194478000_R12"},{"issue":"4","key":"2025122722194478000_R13","doi-asserted-by":"publisher","first-page":"T255","DOI":"10.1190\/INT-2013-0161.1","article-title":"Mineralogy-based brittleness prediction from surface seismic data: application to the Barnett Shale.","volume":"2","author":"Perez Altamar","year":"2014","journal-title":"Interpretation"},{"key":"2025122722194478000_R14"},{"issue":"5","key":"2025122722194478000_R15","doi-asserted-by":"publisher","first-page":"D393","DOI":"10.1190\/geo2013-0051.1","article-title":"Mechanical properties of shale-gas reservoir rocks\u2014Part 2: ductile creep, brittle strength, and their relation to the elastic modulus.","volume":"78","author":"Sone","year":"2013","journal-title":"Geophysics"},{"issue":"5","key":"2025122722194478000_R16","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1080\/08120099.2021.1847733","article-title":"Geomechanical evaluation of a Middle Cambrian unconventional oil and gas play in the Southern Georgina Basin, Northern Australia.","volume":"68","author":"Tenthorey","year":"2021","journal-title":"Australian Journal of Earth Sciences"},{"issue":"4","key":"2025122722194478000_R17","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1177\/0144598716687929","article-title":"Brittleness evaluation of the Upper Ordovician Wufeng\u2013Lower Silurian Longmaxi Shale in Southern Sichuan Basin, China.","volume":"35","author":"Zhang","year":"2017","journal-title":"Energy Exploration & Exploitation"}],"container-title":["The APPEA Journal"],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/62\/2\/S378\/471419\/aj21075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/62\/2\/S378\/471419\/aj21075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T03:19:47Z","timestamp":1766891987000},"score":7.687382,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/ep\/article\/62\/2\/S378\/77318\/Resource-potential-of-the-Carrara-Sub-basin-from"}},"issued":{"date-parts":[[2022,5,13]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,5,13]]}},"URL":"https:\/\/doi.org\/10.1071\/aj21075","ISSN":["1326-4966","2206-8996"],"issn-type":[{"value":"1326-4966","type":"print"},{"value":"2206-8996","type":"electronic"}],"published":{"date-parts":[[2022,5,13]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:49Z","timestamp":1753889809280,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Background: Short sprints have been shown to prevent exercise induced hypoglycaemia in controlled laboratory settings. Using a randomised controlled study design, we tested the hypothesis that incorporating sprinting into moderate intensity exercise can reduce the incidence of exercise mediated hypoglycaemia in individuals with T1D in a real-life setting.<\/jats:p>\n Methods: Individuals with T1D, diagnosed for &gt;1 year, aged 14-35 years, with an HbA1c of \u22649% were recruited into a prospective randomised controlled cross over study. Participants completed three 14-day periods in random order. In one period participants adhered to their usual exercise management (control period), in the other 2 periods, participants additionally incorporated 10s (every 20 mins) or 4s sprints (every 2 mins) into moderate intensity exercise. Outcome measures included the incidence of hypoglycaemia (defined as sensor glucose readings &lt;3.1mmol\/L for \u2265 to 20 minutes) over the 14-day period; and percent time spent &lt;3.1mmol\/L and &lt;3.5mmol\/L. CGM data were analysed using a mixed model approach.<\/jats:p>\n Results: 24 participants completed the study, performing a total of 420 exercise episodes. The 10s period was associated with fewer hypoglycaemia events (&lt;3.1mmol\/L) than the control period (adjusted incidence rate ratio of 0.67, 95% CI 0.46-0.98: p=0.04), with a hypoglycaemia incidence rate of 0.40 (95% CI 0.26-0.55), 0.33 (95% CI 0.21-0.45) and 0.28 (95% CI 0.17-0.38) events per day in the control, 4s and 10s periods respectively. The 10s period was associated with a reduction in time spent &lt;3.5mmol\/L (control vs. 10s period, 3.1% vs. 2.1%, p=0.03) and time spent &lt;3.1mmol\/L (control vs.10s period, 1.9% vs. 1.2%, p= 0.03) compared to the control period. There was no increase in nocturnal hypoglycaemia during the sprinting periods.<\/jats:p>\n Conclusion: In a real-life setting the inclusion of 10s sprints into moderate intensity exercise reduces the incidence of hypoglycaemia, without increasing the risk of nocturnal hypoglycaemia.<\/jats:p>\n \n Disclosure<\/jats:title>\n T. Chetty: None. H. Roby: None. N. Paramalingam: None. J. Dart: None. W. Soon: None. G.J. Smith: None. V.B. Shetty: None. P.A. Fournier: None. T. Jones: None. E.A. Davis: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-747-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:35Z","timestamp":1529693855000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Short Sprints during Exercise Reduce Exercise-Mediated Hypoglycaemia in Type 1 Diabetes in a Real-Life Setting"],"prefix":"10.2337","volume":"67","author":[{"given":"TARINI","family":"CHETTY","sequence":"first","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HEATHER","family":"ROBY","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NIRUBASINI","family":"PARAMALINGAM","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JULIE","family":"DART","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WAYNE","family":"SOON","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GRANT J.","family":"SMITH","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VINUTHA B.","family":"SHETTY","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL A.","family":"FOURNIER","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIM","family":"JONES","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH A.","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/747-P\/58286\/Short-Sprints-during-Exercise-Reduce-Exercise","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/747-P\/58286\/Short-Sprints-during-Exercise-Reduce-Exercise","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:09:32Z","timestamp":1647166172000},"score":7.687375,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/747-P\/58286\/Short-Sprints-during-Exercise-Reduce-Exercise"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-747-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"747-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:56Z","timestamp":1753889816803,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Background: We previously reported an early intervention model of diabetes care, whereby an inpatient diabetes team performed glycemic surveillance and provided proactive management within 24 hours of admission. In the RAPIDS cluster randomized study, early intervention decreased hyperglycemia and hospital-acquired infection (HAI) compared to usual care [Diabetes Care. 2019;42(5):832-40]. We investigated if improvements in ward glucose control and patient outcomes were sustained following the completion of proactive care intervention.<\/jats:p>\n Methods: We performed a 3-month extension observational study on eight medical and surgical wards immediately following the completion of the RAPIDS study, recruiting consecutive inpatients with pre-existing diabetes or new hyperglycemia. Glycemic and clinical outcomes during the three time periods: baseline (usual care), active (proactive care), and extension (usual care) were compared.<\/jats:p>\n Results: We analyzed 1518 inpatients (mean age 71y, 87% type 2 diabetes, 25% insulin-treated) and observed 8610 patient-days. In the intervention wards, during baseline, active and extension periods, patient-day mean glucose were: mean 9.4 (SD 3.3), 9.0 (2.7), and 9.4 (3.1) mmol\/L (p&lt;0.001); and proportion of patient-days with mean glucose &gt;15 mmol\/L were 7.3%, 3.3%, and 5.7% (p&lt;0.001). HAI rates paralleled hyperglycemia: 6.4% during baseline period, 2.4% active period (p=0.022 vs. baseline), and 5.4% extension period (p=0.056 vs. active). In the control wards there was no change in hyperglycemia or HAI rates.<\/jats:p>\n Conclusion: Following withdrawal of proactive care with early intervention, hyperglycemia and HAI rates increased to baseline levels. Ongoing intervention with specialist diabetes care teams may be required to achieve sustained glycemic and clinical improvements in hospital.<\/jats:p>\n \n Disclosure<\/jats:title>\n M. Kyi: None. J. Wang: None. P.R. Wraight: None. P.G. Colman: None. S. Fourlanos: Advisory Panel; Self; Medtronic, Mylan, Sanofi. Speaker\u2019s Bureau; Self; AstraZeneca, Novo Nordisk Inc.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Australian Diabetes Society; Sanofi; National Health and Medical Research Council of Australia (APP1093152); Royal Melbourne Hospital (GIA-030-2019, GIA-027-2016)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-22-or","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:49Z","timestamp":1592238589000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["22-OR: Increased Adverse Glycemia and Hospital-Acquired Infection following Withdrawal of the RAPIDS Early Intervention Model for Diabetes Care in Medical and Surgical Inpatients"],"prefix":"10.2337","volume":"69","author":[{"given":"MERVYN","family":"KYI","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOANNA","family":"WANG","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL R.","family":"WRAIGHT","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER G.","family":"COLMAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SPIROS","family":"FOURLANOS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/22-OR\/55958\/22-OR-Increased-Adverse-Glycemia-and-Hospital","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/22-OR\/55958\/22-OR-Increased-Adverse-Glycemia-and-Hospital","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:26:00Z","timestamp":1647163560000},"score":7.687375,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/22-OR\/55958\/22-OR-Increased-Adverse-Glycemia-and-Hospital"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-22-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"22-OR"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:38:03Z","timestamp":1753889883743,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2021,6,1]]},"abstract":"Contemporary estimates of readmission rates and trends over time following cardiovascular events are required to prioritise clinical care. We estimated the incidence of readmission for myocardial infarction (MI) and heart failure (HF) following an MI, and of readmission for stroke following a stroke, stratified by diabetes status. We included everyone who was discharged from a hospital following an MI or stroke between 1 July 2012 and 30 June 2017 in Victoria, Australia (n=102323). Individuals were followed from discharge following an MI until readmission for MI or HF, or followed from discharge after a stroke until readmission for stroke, censoring at death or 1 year of follow-up. The incidence (per 100 person-years) of readmission for MI decreased in both people with and without diabetes (from 28.9 [95% CI: 27.4, 30.5] to 27.0 [25.6, 28.5] and from 18.5 [17.8, 19.3] to 15.2 [14.5, 16.0] from 2012 to 2016 [years beginning 1 July] in people with and without diabetes, respectively), but the incidence of readmission for HF only improved in people without diabetes (from 23.4 [22.0, 24.9] to 22.5 [21.1, 23.9] and 4.5 [4.1, 4.9] to 3.2 [2.9, 3.5]), and the incidence of readmission for stroke did not change (from 11.0 [9.5, 12.9] to 10.6 [9.2, 12.2] and 10.3 [9.3, 11.3] to 11.2 [10.3, 12.2]). However, the incidence rate ratio for people with vs. without diabetes increased for readmission for MI and HF. The excess risk for readmission for MI and HF for people with diabetes persisted after adjustment for age, sex, socioeconomic status, polypharmacy, comorbidity, and the competing risk of death: with subhazard ratios of 1.32 (1.28, 1.37) for MI and 3.77 (3.57, 3.98) for HF. The effect of diabetes on readmission for MI, but not HF or stroke, was stronger for women than men. Thus, improvements in rates of readmission for MI and HF were greater in people without diabetes than people with diabetes, therefore the excess risk for people with diabetes worsened from 2012-2018.<\/jats:p>\n \n Disclosure<\/jats:title>\n J. I. Morton: None. J. Ilomaki: Consultant; Self; AstraZeneca, Research Support; Self; Amgen Inc., Research Support; Spouse\/Partner; GlaxoSmithKline plc. S. J. Wood: None. D. J. Magliano: None. J. E. Shaw: Advisory Panel; Self; Eli Lilly and Company, Merck Sharp & Dohme Corp., Pfizer Inc., Research Support; Self; AstraZeneca, Speaker\u2019s Bureau; Self; AstraZeneca, Eli Lilly and Company, Novo Nordisk.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Australian Government Research Training Program (to J.I.M.); Monash University (to J.I.M.)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db21-972-p","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T22:15:10Z","timestamp":1624572910000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["972-P: Trends in Rehospitalisation Rates for Myocardial Infarction, Heart Failure, and Stroke in People with and without Diabetes in Australia from 2012-2018"],"prefix":"10.2337","volume":"70","author":[{"given":"JEDIDIAH I.","family":"MORTON","sequence":"first","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENNI","family":"ILOMAKI","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN J.","family":"WOOD","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DIANNA J.","family":"MAGLIANO","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JONATHAN E.","family":"SHAW","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/972-P\/140535\/972-P-Trends-in-Rehospitalisation-Rates-for","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/972-P\/140535\/972-P-Trends-in-Rehospitalisation-Rates-for","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T11:40:46Z","timestamp":1647171646000},"score":7.687375,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/972-P\/140535\/972-P-Trends-in-Rehospitalisation-Rates-for"}},"issued":{"date-parts":[[2021,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db21-972-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2021,6,1]]},"article-number":"972-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:38:02Z","timestamp":1753889882864,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"There are few longitudinal cohort studies in type 1 diabetes that originate in the immediate post-DCCT era. We recruited participants who had initially presented with childhood onset type 1 diabetes (&lt;15 yr age) to a tertiary hospital in Australia between 1990-1992 into the Cognition and Longitudinal Assessment of Risk Factors over 30 Years (CLARiFY) Study. Microvascular co-morbidity outcomes were measured using a clinical neuropathy screening tool and spot urinary albumin to creatinine ratios (ACR). In this interim study, 56 participants had complete neuropathy screening. 7\/56 (12.5%) met the criteria for neuropathy with the mean (SD) HbA1c of 8.57 (1.49) compared to 8.04 (1.46) in the non-neuropathy participants (p-value=0.41). Pearson's correlation coefficients were calculated to assess pairwise associations between HbA1c and continuous neuropathy outcomes and observed non-significant negative correlations between HbA1c and vibration (r=-0.12, P=0.38). Of the 56 participants with neuropathy measurements, 40 also had urine albumin-creatinine ratios (ACR). 27\/40 (67.5%) had normal ACR (ACR&lt;3 mg\/mmol) with HbA1c of 7.8 (1.3); 10\/40 (25.0%) had microalbuminuria (3 mg\/mmol&lt;ACR&lt;30 mg\/mmol) with HbA1c of 10.3 (2.3); and 3\/40 (7.5%) had macroalbuminuria (ACR&gt;30 mg\/mmol) with HbA1c of 10.3 (2.3). Using a one-way ANOVA test, HbA1c was significantly different between the three groups (p-value = 0.01.). Using the ACR as a continuous variable, the Pearson's correlation coefficient with A1c was 0.49 (p-value= 0.001). Collectively, these data show that in a cohort of type 1 adults diagnosed in childhood, elevations of ACR are more common and associate with glycemic control when compared to measures of neuropathy.<\/jats:p>\n \n Disclosure<\/jats:title>\n A.Brown: None. E.L.Feldman: None. E.L.Reynolds: None. O.Gbadeyan: None. C.Moran: None. S.A.Sakowski: None. V.Srikanth: None. E.A.Northam: None. F.Cameron: None. R.Beare: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Institutes of Health (R01DK129320)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-1340-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:33:13Z","timestamp":1687242793000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1340-P: Complications 30 Years from Diagnosis amongst Participants in the Cognition and Longitudinal Assessment of Risk Factors over 30 Years (CLARiFY) Study"],"prefix":"10.2337","volume":"72","author":[{"given":"AMY","family":"BROWN","sequence":"first","affiliation":[{"name":"Parkville, Australia, Ann Arbor, MI, Melbourne, Australia, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EVAN L.","family":"REYNOLDS","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Ann Arbor, MI, Melbourne, Australia, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OYETUNDE","family":"GBADEYAN","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Ann Arbor, MI, Melbourne, Australia, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRIS","family":"MORAN","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Ann Arbor, MI, Melbourne, Australia, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STACEY A.","family":"SAKOWSKI","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Ann Arbor, MI, Melbourne, Australia, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VELANDAI","family":"SRIKANTH","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Ann Arbor, MI, Melbourne, Australia, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELISABETH A.","family":"NORTHAM","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Ann Arbor, MI, Melbourne, Australia, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FERGUS","family":"CAMERON","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Ann Arbor, MI, Melbourne, Australia, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"BEARE","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Ann Arbor, MI, Melbourne, Australia, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EVA L.","family":"FELDMAN","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Ann Arbor, MI, Melbourne, Australia, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1340-P\/150840\/1340-P-Complications-30-Years-from-Diagnosis","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1340-P\/150840\/1340-P-Complications-30-Years-from-Diagnosis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:33:14Z","timestamp":1687242794000},"score":7.6871667,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1340-P\/150840\/1340-P-Complications-30-Years-from-Diagnosis"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-1340-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"1340-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T07:52:19Z","timestamp":1753861939760,"version":"3.41.2"},"reference-count":0,"publisher":"Wiley","issue":"S8","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2024,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Worldwide, coffee and tea are two of the most popular beverages consumed. Studies have suggested a protective role of coffee and tea, including reduced risk of Alzheimer\u2019s disease. However, longitudinal data from large cohorts of older adults reporting associations of coffee and tea intake with cognitive decline is limited.<\/jats:p><\/jats:sec>Method<\/jats:title>Cognitively unimpaired participants (n = 8,451) from UK BioBank (\u226560 years of age) with at least 2 follow up visits (average follow up time 8.83 years) were included. Baseline self\u2010report coffee and tea intake (cups per day) were collected using a questionnaire. Cognitive assessment included Pairs Matching test (errors), Reaction Time test, Numeric Memory test, and Fluid Intelligence. Linear mixed models assessed the relationship between categorical coffee and tea intake and cognitive outcomes, including covariates age, sex, qualification, Townsend deprivation index, ethnicity, Apolipoprotein E \u03b54 status, and body mass index.<\/jats:p><\/jats:sec>Result<\/jats:title>Daily coffee intake predicted the slope of decline in Fluid Intelligence across follow\u2010up (\u03b2<\/jats:italic> = \u20100.02, SE<\/jats:italic> = 0.007, FDR corrected p<\/jats:italic> =\u00a0.004). Those never consuming coffee and those with moderate coffee consumption (1\u20103 cups) had slower declines in Fluid Intelligence compared to those with high coffee consumption (\u00b34 cups, \u03b2<\/jats:italic> = 0.06, SE<\/jats:italic> = 0.02, p<\/jats:italic> =\u00a0.005; \u03b2<\/jats:italic> = 0.07, SE<\/jats:italic> = 0.02, p<\/jats:italic><.001, respectively).<\/jats:p>Daily tea intake predicted decline in Fluid Intelligence across follow\u2010up (\u03b2<\/jats:italic> = 0.02, SE<\/jats:italic> = 0.007, FDR corrected p<\/jats:italic> =\u00a0.044), such that those who never drank tea showed a greater decline in Fluid Intelligence compared to those who had moderate and high tea consumption (\u03b2<\/jats:italic> = 0.06, SE<\/jats:italic> = 0.02, p<\/jats:italic> =\u00a0.009; \u03b2<\/jats:italic> = 0.06, SE<\/jats:italic> = 0.02, p<\/jats:italic> =\u00a0.003, respectively).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our results support the hypothesis that coffee and tea intake may be a protective factor against cognitive decline, particularly for maintaining Fluid Intelligence. However, our results show an upper limit to coffee intake with a maximum of 3 cups\/day being consumed for beneficial effects, and no coffee intake being more beneficial than \u00b34 cups. Conversely, high tea consumption provided positive effects on cognition in addition to moderate consumption, with high tea consumption being more beneficial than no tea consumption. Additional longitudinal observational and intervention studies are required to validate our findings and confirm this hypothesis.<\/jats:p>This research has been conducted using the UK Biobank Resource under Application Number 108907.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.094923","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T10:21:58Z","timestamp":1736418118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Moderate coffee and tea consumption is associated with slower cognitive decline: data from UK Biobank"],"prefix":"10.1002","volume":"20","author":[{"given":"Samantha L","family":"Gardener","sequence":"first","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Alzheimer\u2019s Research Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey R","family":"Sewell","sequence":"additional","affiliation":[{"name":"AdventHealth Research Institute, Neuroscience, Orlando, FL USA"},{"name":"Murdoch University, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Alzheimer\u2019s Research Australia, Perth, Western Australia Australia"},{"name":"Murdoch University, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph N","family":"Martins","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Alzheimer\u2019s Research Australia, Perth, Western Australia Australia"},{"name":"Murdoch University, Perth, Western Australia Australia"},{"name":"Department of Biomedical Sciences, Macquarie University, Macquarie Park, NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie R","family":"Rainey\u2010Smith","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Murdoch University, Perth, Western Australia Australia"},{"name":"Alzheimer's Research Australia, Perth, Western Australia Australia"},{"name":"School of Psychological Science, University of Western Australia, Crawley, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,9]]},"container-title":["Alzheimer's & Dementia"],"language":"en","deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T10:27:29Z","timestamp":1736418449000},"score":7.6871376,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.094923"}},"issued":{"date-parts":[[2024,12]]},"references-count":0,"journal-issue":{"issue":"S8","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/alz.094923"],"URL":"https:\/\/doi.org\/10.1002\/alz.094923","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"type":"print","value":"1552-5260"},{"type":"electronic","value":"1552-5279"}],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2025-01-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e094923"},{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T04:13:16Z","timestamp":1750219996869,"version":"3.41.0"},"publisher-location":"New York, NY, 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Environments"],"prefix":"10.1145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9446-425X","authenticated-orcid":false,"given":"Andrew","family":"Zamecnik","sequence":"first","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6999-3547","authenticated-orcid":false,"given":"Srecko","family":"Joksimovic","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9694-6033","authenticated-orcid":false,"given":"Vitomir","family":"Kovanovic","sequence":"additional","affiliation":[{"name":"University of South Australia, 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We aimed to examine associations between of HbA1c mean and variability and brain structure in a cohort of children diagnosed with T1D before 3 years of age. We recruited children presenting to a tertiary hospital in Australia from 1990-1992 in the Cognition and Longitudinal Assessment of Risk Factors over 30 Years (CLARiFY) Study. HbA1c was serially measured over 30 years after T1D diagnosis. Brain MRI was performed at ~12- and 30-years post diagnosis. We used linear mixed effects modelling to examine associations between mean HbA1c and HbA1c coefficient of variation and brain MRI structural measures. Data were available for 10 subjects (6 female). The mean age of diabetes diagnosis was 1.9 years. The mean HbA1c at 12- and 30-years post diagnosis was 8.5%. We did not find an association between mean HbA1c and any of the brain structures. Greater HbA1c coefficient of variation was associated with less sub-cortical gray matter volume (\u03b2=-41537, p=0.006) and greater cortical thickness (\u03b2=0.47, p=0.02) but not other brain structure measures (Table 1). In these preliminary analyses, we found HbA1c variability associated with measures of gray matter. Work is ongoing to confirm and understand the implications of these results.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n C.Moran: None. O.Gbadeyan: None. A.Brown: None. S.A.Sakowski: None. V.Srikanth: None. F.Cameron: None. E.A.Northam: None. E.L.Feldman: None. R.Beare: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Institutes of Health (R01DK129320)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-1353-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:17:29Z","timestamp":1687238249000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1353-P: Glycemic Control and Longitudinal Brain MRI in Children Diagnosed with Diabetes before 3 Years of Age (CLARiFY Study)"],"prefix":"10.2337","volume":"72","author":[{"given":"CHRIS","family":"MORAN","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Ann Arbor, MI, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OYETUNDE","family":"GBADEYAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Ann Arbor, MI, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AMY","family":"BROWN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Ann Arbor, MI, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STACEY A.","family":"SAKOWSKI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Ann Arbor, MI, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VELANDAI","family":"SRIKANTH","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Ann Arbor, MI, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FERGUS","family":"CAMERON","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Ann Arbor, MI, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELISABETH A.","family":"NORTHAM","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Ann Arbor, MI, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EVA L.","family":"FELDMAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Ann Arbor, MI, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"BEARE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia, Ann Arbor, MI, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1353-P\/149340\/1353-P-Glycemic-Control-and-Longitudinal-Brain-MRI","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1353-P\/149340\/1353-P-Glycemic-Control-and-Longitudinal-Brain-MRI","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:17:31Z","timestamp":1687238251000},"score":7.6866703,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1353-P\/149340\/1353-P-Glycemic-Control-and-Longitudinal-Brain-MRI"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-1353-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"1353-P"},{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:04:03Z","timestamp":1761717843765,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001069","name":"Women and Infants Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013407","name":"Medela","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2012,4]]},"abstract":"The remodelling of the mammary gland during pregnancy\/lactation is fuelled by mammary stem cells. Because most of our knowledge on these cells comes from the resting gland, recent efforts have focused on the lactating gland in which these cells are activated. We non\u2010invasively accessed stem cells from the human lactating gland via freshly expressed breastmilk. We performed ex vivo analysis of the cell subpopulations present in breastmilk using numerous phenotypic and functional stem cell and differentiation markers for various lineages. A population displaying the phenotypic profile of mammary stem cells previously characterised in the resting gland (CD49f+\/CD29+) was identified, able to self\u2010renew and differentiate in vitro into the two main mammary epithelial subtypes. In addition, a population expressing the pluripotency markers Oct\u20104, Sox\u20102, Nanog, SSEA\u20104, Tra\u20101\u201360 and Tra\u20101\u201381 was identified. Culture of these cells in stem cell and differentiation media revealed the potential both for self\u2010renewal and differentiation into cells originating from the three germ layers. The identified subpopulations were also localised in paraffin\u2010embedded human lactating tissues. Based on these results, a new cellular hierarchy is proposed for the human mammary gland, at the top of which sits a cell population with potential pluripotency, which can be easily accessed via breastmilk.<\/jats:p>\n \n \n Grant Funding Source<\/jats:italic>\n <\/jats:bold>\n : Women and Infants Research Foundation, Medela AG<\/jats:italic>\n <\/jats:p>","DOI":"10.1096\/fasebj.26.1_supplement.913.3","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T11:26:13Z","timestamp":1624274773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Breastmilk contains primitive stem cells from the lactating breast with multi\u2010lineage differentiation potential"],"prefix":"10.1096","volume":"26","author":[{"given":"Foteini","family":"Hassiotou","sequence":"first","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Filgueira","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Trengove","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching Tat","family":"Lai","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hartmann","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4]]},"container-title":["The FASEB Journal"],"language":"en","deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:09:52Z","timestamp":1761696592000},"score":7.68627,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fasebj.26.1_supplement.913.3"}},"issued":{"date-parts":[[2012,4]]},"references-count":0,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1096\/fasebj.26.1_supplement.913.3"],"URL":"https:\/\/doi.org\/10.1096\/fasebj.26.1_supplement.913.3","archive":["Portico"],"ISSN":["0892-6638","1530-6860"],"issn-type":[{"type":"print","value":"0892-6638"},{"type":"electronic","value":"1530-6860"}],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"2012-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:40:36Z","timestamp":1759938036804,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"4S_Part_12","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.jalz.2010.05.1211","type":"journal-article","created":{"date-parts":[[2010,7,11]],"date-time":"2010-07-11T20:07:34Z","timestamp":1278878854000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["P2\u2010163: Awareness of cognitive performance in nondemented older adults with cognitive impairment, their informants and healthy controls: The Perth Perception Study"],"prefix":"10.1002","volume":"6","author":[{"given":"Nicola T.","family":"Lautenschlager","sequence":"first","affiliation":[{"name":"University of Melbourne Kew Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn R.","family":"Greenop","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Flicker","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan K.","family":"Foster","sequence":"additional","affiliation":[{"name":"Edith Cowan University Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Beer","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank M.","family":"van Bockxmeer","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Health Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo P.","family":"Almeida","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526010013312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526010013312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.jalz.2010.05.1211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2010.05.1211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.jalz.2010.05.1211","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2010.05.1211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:12:42Z","timestamp":1759936362000},"score":7.685811,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1016\/j.jalz.2010.05.1211"}},"issued":{"date-parts":[[2010,7]]},"references-count":0,"journal-issue":{"issue":"4S_Part_12","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1016\/j.jalz.2010.05.1211"],"URL":"https:\/\/doi.org\/10.1016\/j.jalz.2010.05.1211","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"type":"print","value":"1552-5260"},{"type":"electronic","value":"1552-5279"}],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"2010-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:41:25Z","timestamp":1761896485160},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.juro.2017.02.1155","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T18:34:40Z","timestamp":1491244480000},"source":"Crossref","is-referenced-by-count":2,"title":["MP38-02 BIPARAMETRIC MRI: COULD IT REDUCE THE COST OF MRI WHILE MAINTAINING DIAGNOSTIC ACCURACY FOR PROSTATE CANCER?"],"prefix":"10.1097","volume":"197","author":[{"given":"Lana","family":"Pepdjonovic","sequence":"first","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Huang","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Dat","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mann","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Frydenberg","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Moon","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Snow","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri","family":"Hanegbi","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Landau","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Ryan","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Grummet","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534717313794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534717313794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2017.02.1155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T04:50:01Z","timestamp":1651207801000},"score":7.685803,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2017.02.1155"}},"issued":{"date-parts":[[2017,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1016\/j.juro.2017.02.1155"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2017.02.1155","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2017,4]]}},{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:12:46Z","timestamp":1772989966028,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Journal of Australia"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.5694\/mja2.70156","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:09:56Z","timestamp":1772957396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In the Wake of the National Suicide Prevention Strategy 2025\u20132035: Suicide Prevention in Type 1 Diabetes"],"prefix":"10.5694","volume":"224","author":[{"given":"Rigel","family":"Paciente","sequence":"first","affiliation":[{"name":"The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keely","family":"Bebbington","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alix","family":"Woolard","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Milroy","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_2_1_7_2_1","volume-title":"National Suicide Prevention Strategy 2025\u20132035","author":"National Suicide Prevention Office","year":"2025"},{"key":"e_1_2_1_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-0411"},{"key":"e_1_2_1_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2014.02.009"},{"key":"e_1_2_1_7_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0008"},{"key":"e_1_2_1_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13428"}],"container-title":["Medical Journal of Australia"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.5694\/mja2.70156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.5694\/mja2.70156","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.5694\/mja2.70156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:09:48Z","timestamp":1772971788000},"score":7.685516,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.5694\/mja2.70156"}},"issued":{"date-parts":[[2026,2]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.5694\/mja2.70156"],"URL":"https:\/\/doi.org\/10.5694\/mja2.70156","archive":["Portico"],"ISSN":["0025-729X","1326-5377"],"issn-type":[{"value":"0025-729X","type":"print"},{"value":"1326-5377","type":"electronic"}],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70156"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:58Z","timestamp":1753889818010,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Background: With increasing incidence of obesity, metabolic syndrome is not uncommon in type 1 diabetes (T1D). The association of liver dysfunction and cardiovascular disease is well established in type 2 diabetes but not in T1D. We aim to investigate associations between liver dysfunction and diabetic retinopathy and cardiac autonomic neuropathy (CAN) in adolescents with T1D.<\/jats:p>\n Methods: A longitudinal study of 102 adolescents with T1D with repeated measures of liver function and CAN over 3 years. CAN was defined as 2 or more abnormal heart rate variability measures derived from a 10 minute ECG recording using Labchart Pro (mean HR; Standard deviation of mean NN intervals; root mean squared difference of successive NN intervals; low\/high frequency ratio; geometric measure- Triangular index). Generalized estimating equations were used to explore associations between tertiles of liver function enzymes and cardiac autonomic neuropathy and retinopathy after adjusting for known risk factors.<\/jats:p>\n Results: Baseline mean + age was 14.6 + 1.9yrs, HbA1C 8.2 + 1.4 and median duration 7.2yrs (IQR 4.8-9.6), mean BMI 23 + 4.1. Higher ALT was associated with CAN (Table1) but not retinopathy.<\/jats:p>\n Conclusion: Higher ALT was associated with early CAN in youth with T1D. Inflammation might lead to higher ALT. Further studies into the potential role for obesity, liver dysfunction and CAN are required.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n V. Velayutham: None. P.Z. Benitez-Aguirre: None. M.E. Craig: None. J. Cusumano: None. G. Liew: None. K.C. Donaghue: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-548-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:52Z","timestamp":1592238592000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["548-P: Early Liver Dysfunction Predicts Cardiac Autonomic Neuropathy in Adolescents with Type 1 Diabetes"],"prefix":"10.2337","volume":"69","author":[{"given":"VALLIMAYIL","family":"VELAYUTHAM","sequence":"first","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL Z.","family":"BENITEZ-AGUIRRE","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA E.","family":"CRAIG","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANINE","family":"CUSUMANO","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GERALD","family":"LIEW","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KIM C.","family":"DONAGHUE","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/548-P\/57987\/548-P-Early-Liver-Dysfunction-Predicts-Cardiac","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/548-P\/57987\/548-P-Early-Liver-Dysfunction-Predicts-Cardiac","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:47:23Z","timestamp":1647164843000},"score":7.685366,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/548-P\/57987\/548-P-Early-Liver-Dysfunction-Predicts-Cardiac"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-548-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"548-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:38:21Z","timestamp":1753889901600,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,6,14]]},"abstract":"Introduction: Diabetes-specific distress (DD) is the least evaluated psychological comorbidity among adolescents with type 2 diabetes (T2D). We aimed to assess longitudinally DD levels in adolescents with T2D.<\/jats:p>\n Methods: Adolescents with T2D completed the Diabetes Distress Scale (DDS), World Health Organisation-5 Wellbeing Index (WHO-5), and Patient Health Questionnaire-2 (PHQ-2) at baseline, 3 and 6 months to measure DD levels, general emotional wellbeing, and depressive symptoms, respectively. A linear regression model was used to estimate differences in means and 95% confidence intervals with Generalised Estimating Equations.<\/jats:p>\n Results: Thirty-seven adolescents with T2D participated (24 females, 34 from non-Indigenous background, mean+SD age 15.9\u00b12.2 years, mean diabetes duration of 2.2\u00b11.6 years, median [IQR] HbA1c 6.7[5.9-8.9]%. Adolescents with T2D have persistent DD (highest levels in the emotional burden and regimen-related domains), high depressive symptoms and deterioration of emotional wellbeing over six months (See Table 1).<\/jats:p>\n Conclusion: DD and depressive symptoms persisted over time, whilst emotional wellbeing deteriorated, approaching suboptimal levels in adolescents with T2D. Regular screening and management of DD (especially emotional burden and regimen-related distress) and emotional wellbeing should occur during follow-up of adolescents with T2D.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n Y. Luu: None. M. Shah: None. M. Oxlad: Research Support; Ferring Pharmaceuticals Australia. J.A. Curran: Other Relationship; Novo Nordisk, Eli Lilly and Company. D. Spajic: None. A.S. Pena: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db24-1154-p","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T05:38:21Z","timestamp":1718343501000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1154-P: Diabetes-Specific Distress Persists over Time in Adolescents with Type 2 Diabetes\u2014A Longitudinal Study"],"prefix":"10.2337","volume":"73","author":[{"given":"YASMIN","family":"LUU","sequence":"first","affiliation":[{"name":"North Adelaide, Australia, NEDLANDS, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK","family":"SHAH","sequence":"additional","affiliation":[{"name":"North Adelaide, Australia, NEDLANDS, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MELISSA","family":"OXLAD","sequence":"additional","affiliation":[{"name":"North Adelaide, Australia, NEDLANDS, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JACQUELINE A.","family":"CURRAN","sequence":"additional","affiliation":[{"name":"North Adelaide, Australia, NEDLANDS, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DANA","family":"SPAJIC","sequence":"additional","affiliation":[{"name":"North Adelaide, Australia, NEDLANDS, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALEXIA S.","family":"PENA","sequence":"additional","affiliation":[{"name":"North Adelaide, Australia, NEDLANDS, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/1154-P\/155468\/1154-P-Diabetes-Specific-Distress-Persists-over","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/1154-P\/155468\/1154-P-Diabetes-Specific-Distress-Persists-over","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T05:38:21Z","timestamp":1718343501000},"score":7.6853056,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/1154-P\/155468\/1154-P-Diabetes-Specific-Distress-Persists-over"}},"issued":{"date-parts":[[2024,6,14]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2024,6,14]]}},"URL":"https:\/\/doi.org\/10.2337\/db24-1154-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2024,6,14]]},"article-number":"1154-P"},{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:17Z","timestamp":1787014337498,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2025,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Electronic medical records (EMRs) provide multiple efficiencies in communication to clinicians. The ability to copy and paste text in an EMR can be useful; however, it also conveys a risk of inaccurate documentation. Studies in international settings have described such overuse of copying to result in \u2018note bloat\u2019, with the dilution of relevant clinical information and potential clinical detriment.<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n To determine the frequency of erroneous copying, characterise the component of notes in which this occurs and determine the performance of similarity metrics in the prediction of notes likely to have erroneous copying.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A cross\u2010sectional evaluation of all ward round notes over a 48\u2010h period for all long\u2010stay (>48 h) medical services, except the Acute Medical Unit, at the Lyell McEwin Hospital, a 257\u2010bed tertiary hospital in South Australia. Four similarity metrics were evaluated: longest\u2010sequential series of unchanged characters, similarity score (Difflib SequenceMatcher), Levenshtein distance and the Jaccard index.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n One hundred twenty\u2010eight patients were included. The number of patients who had a ward round note on two consecutive days was 97 out of 128 (75.8%). Erroneous copying was found in 8.3% of ward round notes. All (eight out of eight, 100%) of these instances of erroneous copying were in the \u2018issues list\u2019. A threshold of >850 unchanged sequential characters, when compared with the ward round note the preceding day, demonstrated reasonable performance in the prediction of erroneous copying.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Erroneous copying may occur in up to 8.3% of ward round notes in a variety of medical services. Automated strategies to help address this issue should be explored.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/imj.16590","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T06:38:02Z","timestamp":1732775882000},"page":"84-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Copying in medical documentation: developing an evidence\u2010based approach"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0019-9732","authenticated-orcid":false,"given":"James","family":"Tsimiklis","sequence":"first","affiliation":[{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Howson","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Kovoor","sequence":"additional","affiliation":[{"name":"Ballarat Base Hospital Ballarat Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8310-0853","authenticated-orcid":false,"given":"Sheryn","family":"Tan","sequence":"additional","affiliation":[{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Stretton","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aashray","family":"Gupta","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun","family":"Evans","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Booth","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrirajh","family":"Satheakeerthy","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0495-5774","authenticated-orcid":false,"given":"Lauren","family":"Lim","sequence":"additional","affiliation":[{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Stranks","sequence":"additional","affiliation":[{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Gluck","sequence":"additional","affiliation":[{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Maddison","sequence":"additional","affiliation":[{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3431-9672","authenticated-orcid":false,"given":"Toby","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5130-8628","authenticated-orcid":false,"given":"Stephen","family":"Bacchi","sequence":"additional","affiliation":[{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000028644"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-008-0843-2"},{"key":"e_1_2_7_4_1","unstructured":"Australian Commission on Safety and Quality in Health Care.Documentation of Information. 2024."},{"key":"e_1_2_7_5_1","unstructured":"Difflib \u2013 Helpers for Computing Deltas.Python Documentation. 2024."},{"key":"e_1_2_7_6_1","volume-title":"Levenshtein Distance: Information Theory, Computer Science, String (Computer Science), String Metric, Damerau? Levenshtein Distance, Spell Checker, Hamming Distance","author":"Miller FP","year":"2009"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780471650126.dob0956"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqj046"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4338\/ACI-2016-09-R-0150"},{"key":"e_1_2_7_10_1","first-page":"1178","article-title":"A practical approach for monitoring the use of copy\u2010paste in clinical notes","volume":"2021","author":"Vawdrey DK","year":"2022","journal-title":"AMIA Annu Symp Proc"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.33348"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocaa027"},{"key":"e_1_2_7_13_1","article-title":"Copy\u2010pasting in patients' electronic medical records (EMRs): use judiciously and with caution","volume":"15","author":"Al Bahrani B","year":"2023","journal-title":"Cureus"}],"container-title":["Internal Medicine Journal"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.16590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T23:56:40Z","timestamp":1739923000000},"score":7.6851406,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.16590"}},"issued":{"date-parts":[[2024,11,28]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/imj.16590"],"URL":"https:\/\/doi.org\/10.1111\/imj.16590","archive":["Portico"],"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"published":{"date-parts":[[2024,11,28]]},"assertion":[{"value":"2024-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:50Z","timestamp":1753889810172,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Adverse glycaemia in hospital is associated with worse clinical outcomes. Given the high prevalence of diabetes in the cardiology wards, we introduced an early intervention model of diabetes care in high-risk inpatients aiming to decrease adverse glycaemia. A prospective pre- and post-intervention study was conducted in a tertiary referral hospital cardiology ward. It consisted of an initial 6-month baseline phase of standard care (a \u2018reactive\u2019 referral-based diabetes consultation service), followed by an 9-month intervention phase, comprising a \u2018proactive\u2019 multidisciplinary inpatient diabetes team (IDT) assisted by networked blood glucose (BG) meter technology. The proactive IDT performed electronic surveillance of capillary BG measurements and provided an early consultation service (within 24 hours of admission), without waiting for referral from the parent team. Consecutive inpatients admitted to the cardiology ward (length of stay &gt;48 hours) at high risk of adverse glycaemia (insulin treatment prior to hospital; or BG &lt;4, &gt;15 or two BG &gt;10 mmol\/L in the first 48 hours) were recruited. BG data from day 2 until discharge, along with demographic and clinical features, was collected. The primary outcome was the incidence of adverse glycaemic days (AGD) (rate per 1000 patient-days with any capillary BG measure &lt;4 or &gt;15 mmol\/L). Overall, we observed 332 patients (1320patient-days and 4887 BG measurements). Compared to usual care, the incidence of AGD decreased from 405 to 320 per 1000 patient-days (21% decrease, p=0.002) which remained significant after MVA adjustment. During the intervention phase, there was decreased mean (\u00b1SD) patient-day BG (10.8 \u00b13.3 vs. 10.1 \u00b12.8, p&lt;0.001), decreased patient-days with hyperglycaemia (BG &gt;15 mmol\/L) (10.4% vs. 6.1%, p=0.044) with no significant difference in patient-days with hypoglycaemia. Analysis of clinical outcomes is pending. An early intervention model of diabetes care decreased adverse glycaemia in cardiology in patients with diabetes.<\/jats:p>\n \n Disclosure<\/jats:title>\n S. Fourlanos: None. N.D. Mingos: None. L.M. Rowan: None. R. Barmanray: None. M. Kyi: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-2374-pub","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T02:26:54Z","timestamp":1559701614000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["2374-PUB: Early Diabetes Intervention for High-Risk Cardiology Inpatients"],"prefix":"10.2337","volume":"68","author":[{"given":"SPIROS","family":"FOURLANOS","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NICHOLAS D.","family":"MINGOS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LOIS M.","family":"ROWAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAHUL","family":"BARMANRAY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MERVYN","family":"KYI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/2374-PUB\/60401\/2374-PUB-Early-Diabetes-Intervention-for-High-Risk","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/2374-PUB\/60401\/2374-PUB-Early-Diabetes-Intervention-for-High-Risk","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:10:59Z","timestamp":1647166259000},"score":7.684625,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/2374-PUB\/60401\/2374-PUB-Early-Diabetes-Intervention-for-High-Risk"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-2374-pub","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"2374-PUB"},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:41:03Z","timestamp":1651210863945},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.juro.2016.02.1138","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T07:33:51Z","timestamp":1459150431000},"source":"Crossref","is-referenced-by-count":0,"title":["PD15-12 CORRELATION BETWEEN MULTIPARAMETRIC MRI FINDINGS AND RADICAL PROSTATECTOMY SPECIMENS IN 162 PATIENTS"],"prefix":"10.1097","volume":"195","author":[{"given":"Sean","family":"Huang","sequence":"first","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mann","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Ryan","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Landau","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Snow","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri","family":"Hanegbi","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Moon","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Frydenberg","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Grummet","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534716014269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534716014269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2016.02.1138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:17:07Z","timestamp":1651209427000},"score":7.684625,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2016.02.1138"}},"issued":{"date-parts":[[2016,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1016\/j.juro.2016.02.1138"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2016.02.1138","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2016,4]]}},{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T20:48:05Z","timestamp":1771966085094,"version":"3.50.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"The GDM prevalence has been rising, affecting 7-28% of pregnancies worldwide. Prior systematic reviews examining the success of interventions for GDM prevention have presented results where some interventions have modest effect and others, no effect. The impact of individual characteristics on the efficacy of interventions has not been thoroughly investigated. To address this knowledge gap, we performed a systematic review of controlled trials of lifestyle (diet and exercise), metformin and dietary supplement interventions initiated in the preconception, prenatal or postpartum period to assess whether participant characteristics impact the interventions\u2019 effectiveness in GDM prevention. Overall, 116 studies met inclusion criteria (lifestyle n=92, metformin n=13 and dietary supplements n=12). Lifestyle, metformin and dietary supplements reduced GDM risk by 24% (RR 0.76, 95% CI 0.69-0.83), 34% (RR 0.66, 95% CI 0.47-0.93), and 45% (RR 0.55, 95% CI 0.36-0.83). With lifestyle, lower risks of GDM was seen in individuals with overweight or obesity (n=33, RR 0.70, 95% CI 0.59-0.83), without PCOS (n=3, RR 0.62, 95% CI 0.47-0.82) and without a history of GDM (n=13, RR 0.63, 95% CI 0.53-0.70) (p&lt;0.05). With metformin, lower GDM risks were achieved when commenced prior to conception (n=3, RR 0.22, 95% CI 0.11-0.45)(p&lt;0.01). Dietary supplements resulted in lower GDM risks among individuals with normal weight (n=1, RR 0.42, 95% CI 0.24-0.72), with prediabetes (n=1, RR 0.08, 95% CI 0.02-0.31), and when initiated before 20 weeks\u2019 gestation (n=10, RR 0.46, 95% CI 0.30-0.71) (p&lt;0.05). Given the potentially greater effectiveness of these interventions in certain groups of individuals, future research on tailored recommendations in precision GDM prevention, replacing the current \u2018one-size-fits-all\u2019 approach, is needed.<\/jats:p>\n \n Disclosure<\/jats:title>\n S.Lim: None. R.Taylor: None. M.Pathirana: None. K.Liu: None. G.G.Ukke: None. M.P.Bonham: None. M.Chen: None. A.J.Fawcett: None. S.C.Chivers: None. J.L.Josefson: None. W.W.Takele: None. L.M.Redman: Research Support; Dexcom, Inc., Abbott Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Stock\/Shareholder; ABGIL, Teladoc Health. K.Vesco: Research Support; Pfizer Inc. J.A.Grieger: None. N.Habibi: None. A.Quinteros: None. G.Leung: None. S.J.Zhou: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-612-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:20:33Z","timestamp":1687238433000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["612-P: The Effectiveness of Lifestyle, Metformin, or Dietary Supplements for the Prevention of Gestational Diabetes Mellitus (GDM) by Participant Characteristics\u2014A Systematic Review and Meta-analysis"],"prefix":"10.2337","volume":"72","author":[{"given":"SIEW","family":"LIM","sequence":"first","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WUBET W.","family":"TAKELE","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEANNE M.","family":"REDMAN","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KIMBERLY","family":"VESCO","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JESSICA A.","family":"GRIEGER","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NAHAL","family":"HABIBI","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALEJANDRA","family":"QUINTEROS","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GLORIA","family":"LEUNG","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHAO J.","family":"ZHOU","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RACHAEL","family":"TAYLOR","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MALEESA","family":"PATHIRANA","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAI","family":"LIU","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GEBRESILASEA G.","family":"UKKE","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAXINE P.","family":"BONHAM","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MINGLING","family":"CHEN","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREA J.","family":"FAWCETT","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SIAN C.","family":"CHIVERS","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAMI L.","family":"JOSEFSON","sequence":"additional","affiliation":[{"name":"Box Hill, Australia, Clayton, Australia, Baton Rouge, LA, Portland, OR, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/612-P\/149408\/612-P-The-Effectiveness-of-Lifestyle-Metformin-or","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/612-P\/149408\/612-P-The-Effectiveness-of-Lifestyle-Metformin-or","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:20:33Z","timestamp":1687238433000},"score":7.683775,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/612-P\/149408\/612-P-The-Effectiveness-of-Lifestyle-Metformin-or"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-612-p","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"612-P"},{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:55:10Z","timestamp":1761238510829},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"suppl_1","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2018,4,9]]},"DOI":"10.1093\/jbcr\/iry006.450","type":"journal-article","created":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T19:14:05Z","timestamp":1523301245000},"page":"S237-S237","source":"Crossref","is-referenced-by-count":2,"title":["527 Targeting Lysyl Oxidase (LOX) Activity to Improve Scar Appearance"],"prefix":"10.1093","volume":"39","author":[{"given":"N","family":"Chaudhari","sequence":"first","affiliation":[{"name":"University of Western Australia, Crawley, Australia; Pharmaxis Ltd, Sydney, Australia; burns service Western Australia, Murdoch, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Toshniwal","sequence":"additional","affiliation":[{"name":"University of Western Australia, Crawley, Australia; Pharmaxis Ltd, Sydney, Australia; burns service Western Australia, Murdoch, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Clemons","sequence":"additional","affiliation":[{"name":"University of Western Australia, Crawley, Australia; Pharmaxis Ltd, Sydney, Australia; burns service Western Australia, Murdoch, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Stevenson","sequence":"additional","affiliation":[{"name":"University of Western Australia, Crawley, Australia; Pharmaxis Ltd, Sydney, Australia; burns service Western Australia, Murdoch, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Ryan","sequence":"additional","affiliation":[{"name":"University of Western Australia, Crawley, Australia; Pharmaxis Ltd, Sydney, Australia; burns service Western Australia, Murdoch, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Jarolimek","sequence":"additional","affiliation":[{"name":"University of Western Australia, Crawley, Australia; Pharmaxis Ltd, Sydney, Australia; burns service Western Australia, Murdoch, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Wood","sequence":"additional","affiliation":[{"name":"University of Western Australia, Crawley, Australia; Pharmaxis Ltd, Sydney, Australia; burns service Western Australia, Murdoch, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Fear","sequence":"additional","affiliation":[{"name":"University of Western Australia, Crawley, Australia; Pharmaxis Ltd, Sydney, Australia; burns service Western Australia, Murdoch, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,4,9]]},"container-title":["Journal of Burn Care & Research"],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jbcr\/article-pdf\/39\/suppl_1\/S237\/24770744\/iry006.450.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T08:38:06Z","timestamp":1525423086000},"score":7.682849,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbcr\/article\/39\/suppl_1\/S237\/4965742"}},"issued":{"date-parts":[[2018,4]]},"references-count":0,"journal-issue":{"issue":"suppl_1","published-online":{"date-parts":[[2018,4,9]]},"published-print":{"date-parts":[[2018,4,9]]}},"URL":"https:\/\/doi.org\/10.1093\/jbcr\/iry006.450","ISSN":["1559-047X","1559-0488"],"issn-type":[{"value":"1559-047X","type":"print"},{"value":"1559-0488","type":"electronic"}],"published-other":{"date-parts":[[2018,4]]},"published":{"date-parts":[[2018,4]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:17Z","timestamp":1753889837692,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Background: Glucose variability (GV) may be reflected by variation in either the short-term glucose levels (assessed by continuous glucose monitoring (CGM)) or the long-term by HbA1c or intermediate by 1,5-anhydroglucitol (1,5-AG). In patients with T1DM management by continuous subcutaneous insulin infusion (CSII) is usually associated with improved glycaemia compared to multiple daily insulin injections (MDI). Serum 1,5-anhydroglucitol (1,5-AG) correlates with GV on CGM in adult and pediatric T1D groups. It is not known whether CSII therapy without CGM improves intermediate GV.<\/jats:p>\n Methods: Blood was obtained from children (mean age 14.1 +\/- 1.3 years) within 3-months of T1D diagnosis. Children were treated with CSII (n=12) or MDI (n=15) and followed for a further 1 to 3 time points (median, LQ-UQ 535, 519-563 days follow-up). GV was assessed measuring 1,5-anhydroglucitol (1,5-AG) (GlycoMark, Inc., Winston-Salem, NC). The mean difference, standard deviation (SD) and coefficient of variation (CV) of 1,5-AG and HbA1c was compared between treatment arms.<\/jats:p>\n Results: There was no difference between treatment modalities in baseline HbA1c (median, LQ-UQ 11.8, 10.2-13.5 % (105, 87-124 mmol\/mol) vs. 12.6, 10.3-14.0 % (114, 89-130 mmol\/mol) CSII vs. MDI) nor baseline 1,5-AG (median, LQ-UQ 2.8, 1.8-4.0 \u03bcg\/mL vs. 3.6, 2.1-12.1 \u03bcg\/mL CSII vs. MDI). 1,5-AG improved more (increased) in the CSII vs. MDI group (3.1 +\/- 4.1 vs. -2.2 +\/- 7.0 \u03bcg\/ml respectively, P=0.029). This difference persisted following adjustment for the duration of follow-up. There was no significant difference in the HbA1c improvement between the CSII and MDI groups. There was no significant difference in the SD or CV of 1,5-AG or HbA1c between groups.<\/jats:p>\n Conclusions: Early use of CSII post-T1D-diagnosis in a pediatric population is associated with a higher 1,5-AG than with MDI therapy implying reduced glycaemic variability.<\/jats:p>\n \n Disclosure<\/jats:title>\n E.S. Scott: None. A.S. Januszewski: None. G. Fulcher: Advisory Panel; Self; Boehringer Ingelheim Pharmaceuticals, Inc., Janssen Research & Development, Merck Sharp & Dohme Corp., Novo Nordisk Inc. Consultant; Self; Boehringer Ingelheim Pharmaceuticals, Inc., Janssen Research & Development, Merck Sharp & Dohme Corp., Novo Nordisk Inc. Research Support; Self; Novo Nordisk Inc. T. Jones: Research Support; Self; Dexcom, Inc., Medtronic MiniMed, Inc. Speaker's Bureau; Self; Eli Lilly and Company, Roche Diabetes Care. E.A. Davis: None. A.J. Jenkins: Advisory Panel; Self; Abbott, Australian Diabetes Society, Medtronic. Research Support; Self; Abbott, GlySens Incorporated, Medtronic, Mylan. Speaker\u2019s Bureau; Self; Eli Lilly and Company, Novo Nordisk Inc.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-123-lb","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:45:56Z","timestamp":1559695556000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["123-LB: Continuous Subcutaneous Insulin Infusion from Diagnosis of Type 1 Diabetes Improves Intermediate Glycaemic Variability in Children"],"prefix":"10.2337","volume":"68","author":[{"given":"EMMA S.","family":"SCOTT","sequence":"first","affiliation":[{"name":"Sydney, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GREG","family":"FULCHER","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIMOTHY","family":"JONES","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH A.","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA J.","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/123-LB\/59015\/123-LB-Continuous-Subcutaneous-Insulin-Infusion","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/123-LB\/59015\/123-LB-Continuous-Subcutaneous-Insulin-Infusion","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:56:51Z","timestamp":1647165411000},"score":7.68226,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/123-LB\/59015\/123-LB-Continuous-Subcutaneous-Insulin-Infusion"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-123-lb","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"123-LB"},{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T04:16:31Z","timestamp":1750306591295,"version":"3.41.0"},"publisher-location":"New York, NY, USA","reference-count":2,"publisher":"ACM","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"funder":[{"name":"Australian Government"}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2015,6,18]]},"DOI":"10.1145\/2775292.2778298","type":"proceedings-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T18:43:54Z","timestamp":1434134634000},"page":"161-161","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Jenolan Caves"],"prefix":"10.1145","author":[{"given":"Matt","family":"Adcock","sequence":"first","affiliation":[{"name":"CSIRO 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Learning"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"320","published-online":{"date-parts":[[2015,6,18]]},"reference":[{"key":"e_1_3_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1109\/TRO.2012.2200990"},{"key":"e_1_3_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.4311\/2012EX0287"}],"event":{"name":"Web3D '15: The 20th International Conference on Web3D Technology","sponsor":["SIGGRAPH ACM Special Interest Group on Computer Graphics and Interactive Techniques"],"location":"Heraklion Crete Greece","acronym":"Web3D '15"},"container-title":["Proceedings of the 20th International Conference on 3D Web Technology"],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/2775292.2778298","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/2775292.2778298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T06:16:32Z","timestamp":1750227392000},"score":7.6814723,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/2775292.2778298"}},"subtitle":["bringing the physical world to 3D online education"],"issued":{"date-parts":[[2015,6,18]]},"references-count":2,"alternative-id":["10.1145\/2775292.2778298","10.1145\/2775292"],"URL":"https:\/\/doi.org\/10.1145\/2775292.2778298","published":{"date-parts":[[2015,6,18]]},"assertion":[{"value":"2015-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:58Z","timestamp":1753889818151,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"It is unclear whether acute hyperglycemia impairs exercise performance in T1D. To address this question we compared different exercise performance measures under 3 different conditions: euglycemia with basal insulin, hyperglycemia with basal insulin and hyperglycemia with low insulin.<\/jats:p>\n In a randomized, counter-balanced, blinded study design, we studied 12 recreationally active individuals with T1D (8 males, 4 females, 17.9 \u00b1 3.9 years, HbA1c 7.7 \u00b1 1.0%, mean \u00b1 SD). Each completed exercise testing under 3 conditions: euglycemia (5 mM) with basal insulin (20 mU\/m2 BSA\/min) and hyperglycemia (17 mM) with basal insulin and hyperglycemia with low insulin (5 mU\/m2 BSA\/min). The clamp technique was used to achieve study conditions which were maintained for at least 60 min prior to exercise. Standardised exercise performance assessment consisted of 6 tests: a single cycle ergometer V\u02d92 peak test and the following tests performed in triplicate: 6-sec maximal sprint cycling, vertical jump, grip strength, single leg static balance, and modified Star Excursion Balance Test. Ten simple and choice reaction times were also performed.<\/jats:p>\n Target glucose levels were achieved in all subjects: 4.9 \u00b1 0.03 mM for euglycemia and 17.3 \u00b1 0.04 mM for hyperglycemia (mean \u00b1 SE). Mean exercise testing duration was 110 min (range 90-130 min) with no observed ketosis. Analysis of the 6 exercise performance tests using mixed method models did not show any consistent difference in performance between the 3 study conditions. Choice reaction time was slower in hyperglycemia with low insulin compared to the other conditions (p&lt;0.01).<\/jats:p>\n This is the first study to comprehensively assess the effect of acute hyperglycemia on exercise performance. Our findings show that hyperglycemia in either basal or low insulin condition does not impair exercise performance as measured by a combination of maximal muscle power and strength, postural balance, and maximal aerobic capacity in recreationally active individuals with T1D.<\/jats:p>\n \n Disclosure<\/jats:title>\n K. Rothacker: None. S. Armstrong: None. G.J. Smith: None. N. Benjanuvatra: None. B.S. Lay: None. P.A. Fournier: None. P. Adolfsson: Advisory Panel; Self; Abbott, Eli Lilly and Company, Roche Diagnostics Corporation. Speaker's Bureau; Self; JDRF, Nordic Infucare, Rubin Medical. T. Jones: None. E.A. Davis: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-730-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:35Z","timestamp":1529693855000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Exercise Performance Is Not Impaired by Hyperglycemia in Type 1 Diabetes"],"prefix":"10.2337","volume":"67","author":[{"given":"KAREN","family":"ROTHACKER","sequence":"first","affiliation":[{"name":"Subiaco, Australia, Crawley, Australia, Kungsbacka, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SAM","family":"ARMSTRONG","sequence":"additional","affiliation":[{"name":"Subiaco, Australia, Crawley, Australia, Kungsbacka, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GRANT J.","family":"SMITH","sequence":"additional","affiliation":[{"name":"Subiaco, Australia, Crawley, Australia, Kungsbacka, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NAT","family":"BENJANUVATRA","sequence":"additional","affiliation":[{"name":"Subiaco, Australia, Crawley, Australia, Kungsbacka, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRENDAN S.","family":"LAY","sequence":"additional","affiliation":[{"name":"Subiaco, Australia, Crawley, Australia, Kungsbacka, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL A.","family":"FOURNIER","sequence":"additional","affiliation":[{"name":"Subiaco, Australia, Crawley, Australia, Kungsbacka, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER","family":"ADOLFSSON","sequence":"additional","affiliation":[{"name":"Subiaco, Australia, Crawley, Australia, Kungsbacka, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIM","family":"JONES","sequence":"additional","affiliation":[{"name":"Subiaco, Australia, Crawley, Australia, Kungsbacka, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH A.","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Subiaco, Australia, Crawley, Australia, Kungsbacka, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/730-P\/58260\/Exercise-Performance-Is-Not-Impaired-by","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/730-P\/58260\/Exercise-Performance-Is-Not-Impaired-by","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:09:20Z","timestamp":1647166160000},"score":7.681157,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/730-P\/58260\/Exercise-Performance-Is-Not-Impaired-by"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-730-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"730-P"},{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:06:32Z","timestamp":1767175592359,"version":"build-2238731810"},"reference-count":0,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"14_suppl","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2004,7,15]]},"DOI":"10.1200\/jco.2004.22.90140.3707","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T03:17:42Z","timestamp":1491362262000},"page":"3707-3707","source":"Crossref","is-referenced-by-count":1,"title":["Survival and treatment trends for advanced colorectal cancer (CRC) treated in a University Hospital, 1992\u20132001"],"prefix":"10.1200","volume":"22","author":[{"given":"T. J.","family":"Price","sequence":"first","affiliation":[{"name":"QEH, Adelaide, Australia; Cancer Council South Australia, Adelaide, Australia; DHS, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Pittman","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Cancer Council South Australia, Adelaide, Australia; DHS, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Patterson","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Cancer Council South Australia, Adelaide, Australia; DHS, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Colbeck","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Cancer Council South Australia, Adelaide, Australia; DHS, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sim","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Cancer Council South Australia, Adelaide, Australia; DHS, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Roder","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Cancer Council South Australia, Adelaide, Australia; DHS, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Rieger","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Cancer Council South Australia, Adelaide, Australia; DHS, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hewett","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Cancer Council South Australia, Adelaide, Australia; DHS, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Maddern","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Cancer Council South Australia, Adelaide, Australia; DHS, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Luke","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Cancer Council South Australia, Adelaide, Australia; DHS, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","container-title":["Journal of Clinical Oncology"],"language":"en","link":[{"URL":"http:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/jco.2004.22.90140.3707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T17:22:59Z","timestamp":1574875379000},"score":7.680865,"resource":{"primary":{"URL":"http:\/\/ascopubs.org\/doi\/10.1200\/jco.2004.22.90140.3707"}},"issued":{"date-parts":[[2004,7,15]]},"references-count":0,"aliases":["10.1200\/jco.2004.22.14_suppl.3707"],"journal-issue":{"issue":"14_suppl","published-print":{"date-parts":[[2004,7,15]]}},"alternative-id":["10.1200\/jco.2004.22.90140.3707"],"URL":"https:\/\/doi.org\/10.1200\/jco.2004.22.90140.3707","ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"published":{"date-parts":[[2004,7,15]]}},{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:14:13Z","timestamp":1781075653505,"version":"3.54.1"},"reference-count":48,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"unspecified","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Medical Research Future Fund Emerging Leader Grant","award":["GNT1193862"],"award-info":[{"award-number":["GNT1193862"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,8,21]]},"published-print":{"date-parts":[[2024,9]]},"abstract":"\n Background<\/jats:title>\n Assessing multidisciplinary prehabilitation strategies becomes crucial to pre-emptively counter the physical, psychological and social negative impacts experienced during an allogenic haematopoietic stem cell transplant (allo-HSCT) among acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) patients. Current evidence is restricted to studies during induction chemotherapy, omitting rehabilitation interventions and predominantly using exercise-only approaches without a multidisciplinary framework. The aim of this study is to investigate the feasibility, safety and preliminary efficacy of multidisciplinary prehabilitation in adults offered allo-HSCT.<\/jats:p>\n <\/jats:sec>\n \n Methods and analysis<\/jats:title>\n This 8-week single-group pre-post feasibility study aims to pilot a multidisciplinary prehabilitation intervention for participants undergoing allo-HSCT, with a focus on feasibility and safety. Participants, aged 18 or older, diagnosed with AML or MDS, and offered allo-HSCT, will be recruited between June 2023 and July 2024. The multidisciplinary prehabilitation intervention, conducted by the cancer allied health team at the Royal Adelaide Hospital, includes exercise physiology, physiotherapy, dietetics, social work, occupational therapy and psychology interventions. Consistent with a multidisciplinary treatment approach, each component is tailored to address different aspects of patient care, and adherence calculations will assess patient engagement and compliance. In addition, participants will continue to receive usual care from cancer allied health staff. The primary outcome of the study is to assess the feasibility of a multidisciplinary prehabilitation intervention by evaluating intervention uptake, retention, adherence, acceptability and safety. Secondary outcomes are leg strength, upper-body strength, aerobic fitness, falls risk, anthropometry, nutritional status, quality of life, anxiety, depression, self-efficacy for coping with cancer and distress.<\/jats:p>\n <\/jats:sec>\n \n Ethics and dissemination<\/jats:title>\n Ethics approval for this study has been provided by the Central Adelaide Local Health Network (HREC 2022\/HRE00284). Recruitment for the study commenced in June 2023 and will continue until July 2024. The methods have been designed and are reported according to the SPIRIT and CONSORT-pilot study checklist.<\/jats:p>\n <\/jats:sec>\n \n Trial registration number<\/jats:title>\n The Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12623000052639.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-084372","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T05:12:46Z","timestamp":1725513166000},"page":"e084372","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Investigating the impact of multidisciplinary prehabilitation on deconditioning in patients eligible for haematopoietic allogenic stem cell transplantation: protocol for a feasibility trial"],"prefix":"10.1136","volume":"14","author":[{"given":"Karlee","family":"Naumann","sequence":"first","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7227-2406","authenticated-orcid":false,"given":"Ben","family":"Singh","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Bushaway","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhiannon","family":"Crane","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swapna","family":"Deepak","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, 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Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel","family":"Tolfts","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Virieux","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Wall","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Wilksch","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mabel","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Maher","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"2025120520453374000_14.9.e084372.1","doi-asserted-by":"crossref","DOI":"10.1038\/s41408-021-00425-3","article-title":"Acute myeloid leukemia: current progress and future directions","volume":"11","author":"Kantarjian","year":"2021","journal-title":"Blood Cancer 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transplantation","volume":"11","author":"Janics\u00e1k","year":"2021","journal-title":"World J Transplant"},{"key":"2025120520453374000_14.9.e084372.7","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-017-0057-5"},{"key":"2025120520453374000_14.9.e084372.8","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/s41409-020-0782-z","article-title":"Anxiety, depression, and mental health-related quality of life in survivors of pediatric allogeneic hematopoietic stem cell transplantation: a systematic review","volume":"55","author":"Di Giuseppe","year":"2020","journal-title":"Bone Marrow Transplant"},{"key":"2025120520453374000_14.9.e084372.9","doi-asserted-by":"crossref","first-page":"458","DOI":"10.7861\/clinmed.2019-0257","article-title":"Prehabilitation","volume":"19","author":"Durrand","year":"2019","journal-title":"Clin Med 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It produces images of the electromagnetic conductivity structure of the earth, down to depths of a few hundred metres. The AEM method is fast, with rotary\u2010wing or fixed\u2010wing aircraft acquiring data at speeds of 100\u2013300 km\/h, making it an ideal near\u2010surface reconnaissance tool. The physics of the AEM method is sensitive primarily to the subsurface conductivity, which is influenced by a range of geological factors such as mineral content, porosity, and water content and chemistry. In addition, the inferred subsurface conductivity depends on the accurate measurement and modelling of airborne transmitter and receiver geometries \u2013 a challenging task given the speed of acquisition and variability of wind conditions during an acquisition flight. In this work, we present inferences of the subsurface conductivity over Lake Menindee, New South Wales, Australia, using data from test flights and various AEM systems over a 10\u2010year period (2014\u20132024). The lake storage has varied dramatically over this time, and the test flights have coincided with both high and low water levels. While this difference in storage volume undoubtedly influences the near\u2010surface conductivity, a remarkably consistent interpretation of the regional geology is possible regardless of the hydrologic conditions. While the upper 10 m of the modelled depth sections\u00a0exhibit the greatest time\u2010variability in inferred electromagnetic conductivity, the hypothesis that lakebed near\u2010surface conductivity is significantly correlated with the lake water volume cannot robustly be established. We also provide some information\u2010theoretic calculations for each inversion result to aid in their quantitative comparison. The implications of our study are that subtle, shallow, hydrogeological changes are difficult to image with repeat AEM overflights from different systems. Conversely, we establish that different AEM systems with minimal extra processing robustly image the regional geo\u2010electric structure of the near surface, validated by known stratigraphy and associated geological information, as well as borehole conductivity\u00a0logs.<\/jats:p>","DOI":"10.1111\/1365-2478.70171","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T12:26:23Z","timestamp":1775564783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Decade of Airborne Electromagnetic Surveying Lake Menindee (Australia) Under Varying Water Levels"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6113-6900","authenticated-orcid":false,"given":"A.","family":"Ray","sequence":"first","affiliation":[{"name":"Geoscience Australia Symonston Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"McPherson","sequence":"additional","affiliation":[{"name":"Geoscience Australia Symonston Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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Commonwealth of Australia (Geoscience Australia)."},{"key":"e_1_2_12_54_1","unstructured":"Wong S. I.Roach L.Pitt et\u00a0al.2023. \u201cMultilayered Chronostratigraphic Interpretation of the World's Largest Airborne Electromagnetic Survey Across the Australian Continent.\u201d Paper presented at the Australian Earth Science Convention (AESC) Perth WA Australia."}],"container-title":["Geophysical Prospecting"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1365-2478.70171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1365-2478.70171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1365-2478.70171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:06:33Z","timestamp":1784289993000},"score":7.6794186,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1365-2478.70171"}},"issued":{"date-parts":[[2026,4,7]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/1365-2478.70171"],"URL":"https:\/\/doi.org\/10.1111\/1365-2478.70171","archive":["Portico"],"ISSN":["0016-8025","1365-2478"],"issn-type":[{"value":"0016-8025","type":"print"},{"value":"1365-2478","type":"electronic"}],"published":{"date-parts":[[2026,4,7]]},"assertion":[{"value":"2025-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70171"},{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:27:54Z","timestamp":1787833674388,"version":"build-2784847793"},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"6_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,3,22]]},"abstract":"Abstract<\/jats:title>\n Cyclin-dependent kinases (CDKs) are a vital family of proteins in the cell development. Several CDK4\/6 inhibitor drugs significantly extended the lives of subtypes breast cancer patients. However, they have some shortcomings. Many patients do not respond to them well mainly due to off-target toxicity requiring dose reductions and treatment interruptions, and thus building resistance, which limit their effectiveness. Here, we describe AU2-94, a highly selective CDK4 inhibitor, for the treatment of CDK4-dependent tumours including breast cancer (ER+ and TNBC), colorectal cancer and glioblastoma (GBM). AU2-94 exhibits high selectivity for CDK4 (Ki = 2 nM) over CDK6 (Ki = 279 nM). Consistent with the CDK4-targeted mechanism, AU2-94 arrested the G1 cells and inhibited cancer cell proliferation. Interestingly, AU2-94 reduced cellular CDK2, Cyclin E2, Cyclin A2, Cyclin B1, and induced apoptosis via reduction of Bcl-2, FOXM1 etc. In contrast to cancer cells, AU2-94 has little impact on the cell cycle, senescence, or apoptosis of human bone marrow cells, whereas the known CDK4\/6 inhibitors increased the G1 cells. AU2-94 showed little or no effect on lymphocyte and neutrophil counts whilst the clinical CDK4\/6 inhibitors reduced them. This lower effect of AU2-94 on the bone marrow, neutrophils and lymphocytes might be due to its lesser effect on CDK6 compared to the clinical CDK4\/6 inhibitors. AU2-94 was highly efficacious against multiple in vivo tumour models. In the ER+ breast cancer T47D xenografts, AU2-94 caused tumour regression. In the model of MDA-MB-453 AR+ luminal breast cancer (CDK4, KRASmut, PI3KCAmut), AU2-94 demonstrated remarkable efficacy, resulting in the 6 out of 7 (86%) mice tumour-free. In the colorectal cancer HCT116 (CDK4\/6, KRASmut) xenografts, AU2-94 inhibited tumour growth markedly in a dose-dependent manner from 25 to 200 mg\/kg without any overt toxicity. The pharmacokinetic and pharmacodynamic study revealed up to 500-fold higher concentration of AU2-94 in the tumours than in the plasma, suggesting its tumour targeting specificity. Several robust biomarkers\/PD markers were identified. The Rb-CDK4-Cyclin D pathway is altered in the majority of GBM due to homozygous deletion of CDKN2A\/B. AU2-94 has an excellent therapeutic potential as it crossed the blood-brain-barrier effectively. In the both U87 subcutaneous and orthotopic models, AU2-94 reduced the tumour burden and increased the survival of GBM bearing mice significantly compared to vehicle. Moreover, AU2-94 synergised the anti-cancer efficacy of PI3K\/Akt\/mTOR and HER2 inhibitors in combination. In summary, AU2-94 is a CDK4 inhibitor with high selectivity against a panel of 360 human kinases. This selectivity can be a reason for the better safety of AU2-94 compared to the clinical CDK4\/6 inhibitors. The high oral bioavailability, robust antitumor efficacy and excellent safety profiles make AU2-94 a highly attractive candidate for clinical development.<\/jats:p>\n Citation Format: Laychiluh Bantie, Jimma Likisa, Muhammed Rahaman, Theodosia Teo, Ava Safaroghliazar, Sunita KC Basnet, Ramin Hassankhani, Benjamin Noll, Robert Milne, Shudong Wang. AU2-94: A CDK4-specific inhibitor with the marked anti-tumor efficacy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5701.<\/jats:p>","DOI":"10.1158\/1538-7445.am2024-5701","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T12:23:02Z","timestamp":1711110182000},"page":"5701-5701","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Abstract 5701: AU2-94: A CDK4-specific inhibitor with the marked anti-tumor efficacy"],"prefix":"10.1158","volume":"84","author":[{"given":"Laychiluh","family":"Bantie","sequence":"first","affiliation":[{"name":"1University of South Australia, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimma","family":"Likisa","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Rahaman","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodosia","family":"Teo","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ava","family":"Safaroghliazar","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita KC","family":"Basnet","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Hassankhani","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Noll","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Milne","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shudong","family":"Wang","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/84\/6_Supplement\/5701\/741752\/Abstract-5701-AU2-94-A-CDK4-specific-inhibitor","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/84\/6_Supplement\/5701\/741752\/Abstract-5701-AU2-94-A-CDK4-specific-inhibitor","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T12:23:13Z","timestamp":1711110193000},"score":7.6788816,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/84\/6_Supplement\/5701\/741752\/Abstract-5701-AU2-94-A-CDK4-specific-inhibitor"}},"issued":{"date-parts":[[2024,3,22]]},"references-count":0,"journal-issue":{"issue":"6_Supplement","published-print":{"date-parts":[[2024,3,22]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2024-5701","ISSN":["1538-7445"],"issn-type":[{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2024,3,22]]}},{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T14:14:08Z","timestamp":1767622448901,"version":"3.48.0"},"reference-count":0,"publisher":"American 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Knapman","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Randwick, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Patti","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Randwick, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Butlin","sequence":"additional","affiliation":[{"name":"Macquarie University, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.C.","family":"Gandevia","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Randwick, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Butler","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Randwick, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.J.","family":"Eckert","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bilston","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia, Randwick, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,5,1]]},"event":{"name":"American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA"},"container-title":["D29. SRN: NOVEL THERAPEUTIC APPROACHES TOWARDS SDB: CAN PATHOPHYSIOLOGY LEND A HELPING HAND?"],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T11:07:36Z","timestamp":1767611256000},"score":7.6788416,"resource":{"primary":{"URL":"https:\/\/www.atsjournals.org\/doi\/10.1164\/ajrccm-conference.2020.201.1_MeetingAbstracts.A6444"}},"issued":{"date-parts":[[2020,5]]},"references-count":0,"alternative-id":["10.1164\/ajrccm-conference.2020.201.1_MeetingAbstracts.A6444","10.1164\/ajrccm-conference.2020.D29"],"URL":"https:\/\/doi.org\/10.1164\/ajrccm-conference.2020.201.1_meetingabstracts.a6444","published":{"date-parts":[[2020,5]]}},{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:35:53Z","timestamp":1777498553339,"version":"3.51.4"},"reference-count":69,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Metagenics Australia"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Evid Based Complementary Altern Med"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"The aim of this study was to investigate the efficacy and suitability of a brief integrative intervention, Personalized Integrative Therapy (PI Therapy), for the treatment of adult depression and\/or anxiety. In this 6-week, 3-arm, parallel-group, randomized trial, PI Therapy delivered alone or with nutritional supplements (PI Therapy + Supps) was compared to cognitive behavior therapy (CBT) in 48 adults with depression and\/or anxiety. All treatments were delivered as a 1-day workshop plus 6 weeks of reminder phone text messages to reinforce topics and skills covered in the workshop. Affective symptoms decreased significantly and to the same extent in all 3 conditions. At the end of treatment, 33% to 58% of participants reported levels of depressive symptoms in the normal range, and 50% to 58% reported nonclinical levels of anxiety. Compared to CBT and PI Therapy, PI Therapy + Supps was associated with significantly greater improvements in sleep quality. These findings suggest that a brief integrative intervention with or without supplements was comparable to CBT in reducing affective symptoms in adults with depression and\/or anxiety. However, sleep quality improved only in the PI Therapy + Supps condition. 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Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Objective: The renal and retinal vasculature shares similar pathophysiologic features. Retinal vasculature changes, even without typical retinopathy, can predict microvascular disease in type 1 diabetes (T1D). We hypothesise that peripheral retinal vessels are wider and predict incident renal dysfunction in adolescents with T1D.<\/jats:p>\n Research Design and Methods: In this longitudinal study of 441 retinopathy free and normoalbuminuric adolescents with T1D retinal photographs were measured by computer software (Singapore I Vessel Assessment) with vessel calibres summarized in the standard \u201ccentral zone\u201d [Central Retinal Arterial and venular equivalents (CRAE and CRVE respectively)] and \u201cextended zone\u201d [Mean width of arterioles and venules (MWa and MWv)]. Retinal vascular geometry including length diameter ratio (LDR) and simple tortuosity (ST) was quantified. Generalised estimating equation was used to explore associations between vessel calibres, LDR, ST and incident renal dysfunction. Incident renal dysfunction was defined as Albumin excretion rate (AER) &gt; 7.5\u00b5g\/min, with results expressed as odds ratio (OR) and 95% CI.<\/jats:p>\n Results: Mean \u00b1 SD age was 14.1\u00b11.5 year, median diabetes duration 4.8 year [IQR 3.3, 7.5], A1C 8.4 \u00b11.3% (IFCC 68 \u00b114.2mmol\/mol). Incident renal dysfunction occurred in 186\/441 (42%) over a median 4 year follow-up. Wider MWa and MWv (4th vs. 1st quartile), higher LDR (4th vs. 1st -3rd quartile) and lower ST (1st vs. 2nd-4th quartile) were associated with renal dysfunction: MWa OR 2.0 (1.2, 3.5); MWv 2.2 (1.3, 3.6), LDRa 1.5(1.07, 2.08), LDRv 1.4 (1.02, 1.9), STa 1.5(1.1, 2.2), STv 1.4 (1.1, 1.8) after adjusting for covariates (A1C, diabetes duration, gender, height and blood pressure). Central vessels were not related to renal dysfunction: CRAE: 0.9 (0.5, 1.5); CRVE: 1.3 (0.8, 2.1), all p&lt;0.05.<\/jats:p>\n Conclusions: We speculate that small vessel dilatation and tortuosity are modulators of diabetic renal disease.<\/jats:p>\n \n Disclosure<\/jats:title>\n V. Velayutham: None. M.E. Craig: None. G. Liew: None. T.Y. Wong: None. A. Jenkins: Research Support; Self; Medtronic, Mylan, Sanofi-Aventis. K.C. Donaghue: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-542-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:33Z","timestamp":1529693853000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Wider Peripheral Retinal Vessel Predicts Renal Dysfunction in Adolescents with Type 1 Diabetes"],"prefix":"10.2337","volume":"67","author":[{"given":"VALLIMAYIL","family":"VELAYUTHAM","sequence":"first","affiliation":[{"name":"Campbelltown, Australia, Westmead, Australia, Sydney, Australia, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA E.","family":"CRAIG","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Westmead, Australia, Sydney, Australia, Singapore, 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The rapid transition from campus to online teaching\u2013how are students \u2019 perception of learning experiences affected?European Journal of Engineering Education( 2021 ), 1\u201319. Per Warfvinge, Jennifer L\u00f6fgreen, Karim Andersson, Torgny Rox\u00e5, and Christina \u00c5kerman. 2021. The rapid transition from campus to online teaching\u2013how are students\u2019 perception of learning experiences affected?European Journal of Engineering Education(2021), 1\u201319."},{"key":"e_1_3_2_1_18_1","unstructured":"Eiji Yamamura and Yoshiro Tsustsui. 2021. School closures and mental health during the COVID-19 pandemic in Japan. Journal of Population Economics(2021) 1\u201338. Eiji Yamamura and Yoshiro Tsustsui. 2021. School closures and mental health during the COVID-19 pandemic in Japan. Journal of Population Economics(2021) 1\u201338."}],"event":{"name":"GoodIT 2022: ACM International Conference on Information Technology for Social Good","location":"Limassol Cyprus","acronym":"GoodIT 2022","sponsor":["SIGCAS ACM Special Interest Group on Computers and Society"]},"container-title":["Proceedings of the 2022 ACM Conference on Information Technology for Social Good"],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3524458.3547232","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3524458.3547232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T17:50:58Z","timestamp":1750182658000},"score":7.6775227,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3524458.3547232"}},"issued":{"date-parts":[[2022,9,7]]},"references-count":18,"alternative-id":["10.1145\/3524458.3547232","10.1145\/3524458"],"URL":"https:\/\/doi.org\/10.1145\/3524458.3547232","published":{"date-parts":[[2022,9,7]]},"assertion":[{"value":"2022-09-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:23:38Z","timestamp":1761719018235,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2012,4]]},"abstract":"\n Breastmilk contains an array of biochemical and cellular components that provide nutrition and protection to the infant. It has been previously known that pre\u2010feed milk has lower fat and cell contents compared to post\u2010feed milk. To further elucidate the relationship between the degree of fullness of the breast and the fat\/cell milk content, we collected 5 mL of milk from 6 breastfeeding women at specific time points around the first morning feed (immediately prior and after the feed, and then every 30 min for the next 3 hours). Each participant repeated this 2\u20134 times on different days. A 24\u2010hour milk production measurement allowed calculation of the degree of fullness of the breast at each time point. Cell viability was high in all samples (92\u00b10.3%). Fat content varied from 1.3% (when the breast was full) to 16.6% (when the breast was empty), and similarly, cell content varied from 10.6\u00d710\n 3<\/jats:sup>\n to 3.9\u00d710\n 6<\/jats:sup>\n viable cells\/mL milk. Remarkably, a concurrent response of fat and cell contents to the degree of fullness of the breast was observed. Although post\u2010feed milk had higher fat and cell contents compared to pre\u2010feed milk, as known previously, even higher fat and cell contents were obtained 30 min after the feed, with gradual reduction to return to pre\u2010feed levels at 3+ hours post\u2010feed. Ongoing work is examining the mechanisms behind this phenomenon and potential concurrent changes of biochemical and cellular breastmilk composition.\n <\/jats:p>\n \n \n Grant Funding Source<\/jats:italic>\n <\/jats:bold>\n : Women and Infants Research Foundation, Medela AG<\/jats:italic>\n <\/jats:p>","DOI":"10.1096\/fasebj.26.1_supplement.390.2","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T11:47:48Z","timestamp":1624276068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Coordinated response of the fat and cellular content of breastmilk to the degree of fullness of the breast"],"prefix":"10.1096","volume":"26","author":[{"given":"Foteini","family":"Hassiotou","sequence":"first","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Filgueira","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Hepworth","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Trengove","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching Tat","family":"Lai","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hartmann","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4]]},"container-title":["The FASEB Journal"],"language":"en","deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:14:25Z","timestamp":1761696865000},"score":7.67456,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fasebj.26.1_supplement.390.2"}},"issued":{"date-parts":[[2012,4]]},"references-count":0,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1096\/fasebj.26.1_supplement.390.2"],"URL":"https:\/\/doi.org\/10.1096\/fasebj.26.1_supplement.390.2","archive":["Portico"],"ISSN":["0892-6638","1530-6860"],"issn-type":[{"type":"print","value":"0892-6638"},{"type":"electronic","value":"1530-6860"}],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"2012-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T23:13:04Z","timestamp":1656112384559},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"13_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2017,7,1]]},"abstract":"Abstract<\/jats:title>\n Cyclin D dependent kinases CDK4 & CDK6 are crucial regulators of the G1 to S phase transition of the cell cycle. The facts that myriad cancer types show aberrance in INK4-CDK4\/6-cyclin D-Rb-E2F pathway, & the rapidly emerging positive clinical data of pharmacological inhibitors have validated CDK4\/6 as anticancer drug targets. As the first commercialized CDK inhibitor, palbociclib in combination with letrozole or fulvestrant has received regulatory approval for the treatment of breast cancer. This represents an important scientific advance in the field. However, the limited structural diversity & undesired side effects due to broader kinase interactions of existing inhibitors mean that the hunt for new & highly selective CDK4\/6 inhibitor drug candidates continues. Using our advanced medicinal chemistry, targeted biochemical & cell-based assays, & animal pharmacology, we synthesized & evaluated a novel series of inhibitors. Many compounds were highly potent & selective against CDK4\/6, & exhibited low nanomolar potency against a range of human cancer cell lines. Notably, inhibition of CDK4D1 by compound CDKI-15 (Ki = 4 nM) was over 3 orders of magnitude greater than CDK1B, CDK2A, CDK7H & CDK9T1. Interrogation of a panel of 369 protein kinases revealed CDKI-15 to be highly selective for CDK4\/6 with only 3 other kinases inhibited potently. CDKI-15 reduced the level of Rb phosphorylation & induced G1 cell cycle arrest, confirming cellular inhibition of CDK4\/6 in cancer cells. Moreover, CDKI-15 possesses superior pharmacokinetic profile with oral bioavailability of 100% in mice. Treatment of nude BALB\/c mice bearing human MV4-11 acute myeloid leukemia cells with CDKI-15 at daily dose of 100 mg\/kg by oral administration resulted in a robust inhibition of tumor growth compared to vehicle treated animals (T\/C = 30%, p &lt; 0.00001). Strikingly, CDKI-15 caused a complete & sustained tumor regression in one-third of the animals. No detectable toxicity was observed in the animals during & post treatment. Taken together, our data provide a rationale for CDKI-15 to be developed towards clinic for cancer therapy.<\/jats:p>\n Citation Format: Solomon Tadesse, Laychiluh Bantie, Khamis Tomusange, Saiful Islam, Muhammed H. Rahaman, Benjamin Noll, Frankie Lam, Mingfeng Yu, Shudong Wang. CDKI-15, a novel and highly selective CDK4\/6 inhibitor: discovery, in vitro and in vivo anticancer efficacy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2353. doi:10.1158\/1538-7445.AM2017-2353<\/jats:p>","DOI":"10.1158\/1538-7445.am2017-2353","type":"journal-article","created":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T21:38:26Z","timestamp":1501537106000},"page":"2353-2353","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 2353: CDKI-15, a novel and highly selective CDK4\/6 inhibitor: discovery, in vitro<\/i> and in vivo<\/i> anticancer efficacy"],"prefix":"10.1158","volume":"77","author":[{"given":"Solomon","family":"Tadesse","sequence":"first","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laychiluh","family":"Bantie","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khamis","family":"Tomusange","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saiful","family":"Islam","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed H.","family":"Rahaman","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Noll","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frankie","family":"Lam","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingfeng","family":"Yu","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shudong","family":"Wang","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/77\/13_Supplement\/2353\/617869\/Abstract-2353-CDKI-15-a-novel-and-highly-selective","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/77\/13_Supplement\/2353\/617869\/Abstract-2353-CDKI-15-a-novel-and-highly-selective","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T22:29:59Z","timestamp":1656109799000},"score":7.6741333,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/77\/13_Supplement\/2353\/617869\/Abstract-2353-CDKI-15-a-novel-and-highly-selective"}},"issued":{"date-parts":[[2017,7,1]]},"references-count":0,"journal-issue":{"issue":"13_Supplement","published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2017-2353","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2017,7,1]]}},{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T03:27:05Z","timestamp":1764214025492,"version":"3.46.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"am","delay-in-days":377,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["CE200100025"],"award-info":[{"award-number":["CE200100025"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Prom J of Aust"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Fly\u2010in fly\u2010out (FIFO) work is a popular form of rotational work implemented by mining and resource companies to connect employees living in urban areas to operations in rural locations. Research outlining the potential risks that FIFO workplaces pose to employee wellbeing has led to initiatives promoting physical and mental health on\u2010site. However, the potential impact of FIFO work on non\u2010travelling family members, who are also impacted, remains under\u2010researched. This commentary draws upon theoretical and empirical perspectives that compel us to contextualise FIFO work as a\n family<\/jats:italic>\n experience. We then highlight the role of the health promotion community in helping to identify how FIFO work intersects with family health and functioning, and in developing evidence\u2010based health promotion initiatives to support FIFO families. As FIFO work will continue to be a common form of employment for many families, ensuring that these families have access to tailored and targeted support is an essential target for Australia's health promotion community.\n <\/jats:p>","DOI":"10.1002\/hpja.70118","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:37:56Z","timestamp":1760416676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Promoting the Health of Fly\u2010In\u2010Fly\u2010Out (\n FIFO<\/scp>\n ) Families: Considerations for the Health Promotion Community"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-8104","authenticated-orcid":false,"given":"Vincent O.","family":"Mancini","sequence":"first","affiliation":[{"name":"The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6972-2875","authenticated-orcid":false,"given":"Thomas","family":"Nevill","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5660-7886","authenticated-orcid":false,"given":"Briana","family":"Guerrini","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5094-239X","authenticated-orcid":false,"given":"Gregory","family":"Tsuklis","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534484310384958"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2003.10.021"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/08870446.2023.2190348"},{"volume-title":"Impact of FIFO Work Arrangements on the Mental Health and Wellbeing of FIFO Workers","year":"2018","author":"Parker S. F. L.","key":"e_1_2_11_5_1"},{"key":"e_1_2_11_6_1","unstructured":"M. A.Barclay J.Harris J.Everingham P.Kirsch S.Arend andS.Shi \u201cFactors Linked to the Well\u2010Being of Fly\u2010In Fly\u2010Out (FIFO) Workers \u201d2013Centre for Social Responsibility in Mining and Minerals Industry Safety and Health Centre Sustainable Minerals Institute University of Queensland."},{"volume-title":"Women and the Mine of the Future. A Gendered Analysis of Employment and Skills in the Large\u2010Scale Mining Sector: Australia","year":"2022","author":"Weldegiorgis F.","key":"e_1_2_11_7_1"},{"volume-title":"Submission to the House Standing Committee on Regional Australia of Fly\u2010In and Fly\u2010Out (FIFO) Workforce Practices in Regional Australia","year":"2011","author":"Rolfe J.","key":"e_1_2_11_8_1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1071\/AH18155"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/20413866221134938"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019516"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192513X211071061"},{"volume-title":"Family Stress and Coping in the Fly\u2010In Fly\u2010Out Workforce","year":"2009","author":"Taylor J.","key":"e_1_2_11_13_1"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10826-016-0437-2"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/13668800801890129"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10826-015-0183-x"},{"key":"e_1_2_11_17_1","unstructured":"E. R.BrookandE. R.Brook \u201cFly\u2010In\/Fly\u2010Out Working Arrangements: Employee Perceptions of Work and Personal Impacts \u201dPhD thesis Murdoch University 2020."},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1584.2011.01205.x"},{"volume-title":"Workforce Turnover in FIFO Mining Operations in Australia: An Exploratory Study","year":"2003","author":"Beach R.","key":"e_1_2_11_19_1"},{"volume-title":"Mentally Healthy Workplaces for Fly\u2010In Fly\u2010Out (FIFO) Workers in the Resources and Construction Sectors\u2014Code of Practice","year":"2019","author":"Health CfOSa","key":"e_1_2_11_20_1"},{"volume-title":"Act No. 36 of 2020 [Internet]","year":"2020","author":"Work Health and Safety Act 2020 (WA)","key":"e_1_2_11_21_1"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhtm.2015.11.002"},{"key":"e_1_2_11_23_1","unstructured":"Department of Defence Department of Veterans' Affairs\u201cDefence and Verteran Family Wellbeing Strategy 2025\u20132030 \u201dAustralian Government2024."}],"container-title":["Health Promotion Journal of Australia"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/hpja.70118","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hpja.70118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T02:41:35Z","timestamp":1764211295000},"score":7.6737533,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hpja.70118"}},"issued":{"date-parts":[[2025,10]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/hpja.70118"],"URL":"https:\/\/doi.org\/10.1002\/hpja.70118","archive":["Portico"],"ISSN":["1036-1073","2201-1617"],"issn-type":[{"type":"print","value":"1036-1073"},{"type":"electronic","value":"2201-1617"}],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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Journal"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1111\/imj.70366","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T09:40:42Z","timestamp":1775727642000},"page":"1108-1108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cervical screening in immunosuppressed women: a call for broader clinical awareness"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5118-9478","authenticated-orcid":false,"given":"Stephanie","family":"Tan","sequence":"first","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"},{"name":"Sir Charles Gairdner Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Cole","sequence":"additional","affiliation":[{"name":"Fremantle Hospital Fremantle Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael S","family":"Foster","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"},{"name":"Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"Fiona Stanley Hospital Perth Western Australia Australia"},{"name":"Perth Children's Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Leake","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Murray","sequence":"additional","affiliation":[{"name":"South Terrace Clinic FHHS\/ FSH, Alma Rd Fremantle Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5902-040X","authenticated-orcid":false,"given":"Bernadette M","family":"Ricciardo","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"},{"name":"Fiona Stanley Hospital Perth Western Australia Australia"},{"name":"Perth Children's Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_1_3_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000866"},{"key":"e_1_2_1_3_3_1","unstructured":"Cancer Council Australia.Cervical Cancer Screening Program Guidelines[cited 2025 Mar 6]. Available from URL:https:\/\/www.cancer.org.au\/clinical-guidelines\/cervical-cancer\/cervical-cancer-screening"},{"key":"e_1_2_1_3_4_1","unstructured":"The Australian Immunisation Handbook[cited 2025 Aug 26]. Available from URL:https:\/\/immunisationhandbook.health.gov.au\/contents\/vaccine-preventable-diseases\/human-papillomavirus-hpv."}],"container-title":["Internal Medicine Journal"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.70366","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.70366","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.70366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T08:09:58Z","timestamp":1782202198000},"score":7.6735377,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.70366"}},"issued":{"date-parts":[[2026,4,9]]},"references-count":3,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/imj.70366"],"URL":"https:\/\/doi.org\/10.1111\/imj.70366","archive":["Portico"],"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"published":{"date-parts":[[2026,4,9]]},"assertion":[{"value":"2025-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:45Z","timestamp":1753889865755,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Background: Specialist care may improve outcomes for inpatients with diabetes. However, research specific to type 1 diabetes (T1D) is lacking. We aimed to investigate whether automatic alerts from the Electronic Medical Record (EMR) enable prompt review of inpatients with T1D by a specialist diabetes team.<\/jats:p>\n Methods: The type 1 diabetes identification (\u201cT1DI\u201d) initiative was established to improve identification and review of inpatients with T1D by a specialist diabetes team. A specific T1DI code was entered into the EMR of patients with T1D. On subsequent admission, the specialist diabetes team received an automatic message and generated a list of inpatients requiring review. \u201cT1DI\u201d admissions of more than 1-day were analysed over a 1-year period (1 January-31 December 2018). The control group was T1D admissions as coded by health information services following discharge. Analysis was performed for patients admitted to units other than endocrinology to investigate review outcomes. Data was analysed using Chi2 (categorical), Wilcoxon rank sum (continuous) and random effects logistic or negative binomial regression models.<\/jats:p>\n Results: There were 136 admissions of adults with T1D over the study period (T1DI n=67, control n=69). The median age was 49 (IQR 33-64) years; 53% were females. Specialist diabetes team review was more common in the T1DI cohort compared to the control group (endocrinology review AOR 10.27, CI 2.26-46.55, P=0.003; diabetes education review AOR 7.22, CI 2.73-19.10, P&lt;0.001). Prompt endocrinology review (no later than day 2 of admission) was more likely in T1DI inpatients (AOR 2.77, CI 1.15-6.65, P=0.023).<\/jats:p>\n Conclusion: The T1DI initiative was associated with improvements in occurrence and timing of specialist diabetes team review for inpatients with T1D. This initiative could be implemented in other hospitals with EMR systems, enabling more effective identification and management of T1D in the inpatient setting.<\/jats:p>\n \n Disclosure<\/jats:title>\n R. Loveridge: None. N. Torkamani: None. S.L. Patterson: None. L. Churilov: None. E.I. Ekinci: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-1237-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:46Z","timestamp":1592238586000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1237-P: The Type 1 Diabetes Identification Initiative: Improving the Care of Inpatients with Type 1 Diabetes"],"prefix":"10.2337","volume":"69","author":[{"given":"REBECCA","family":"LOVERIDGE","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NILOUFAR","family":"TORKAMANI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SIMONE L.","family":"PATTERSON","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEONID","family":"CHURILOV","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIF I.","family":"EKINCI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Heidelberg, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1237-P\/61053\/1237-P-The-Type-1-Diabetes-Identification","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1237-P\/61053\/1237-P-The-Type-1-Diabetes-Identification","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:21:14Z","timestamp":1647166874000},"score":7.6735215,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1237-P\/61053\/1237-P-The-Type-1-Diabetes-Identification"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-1237-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"1237-P"},{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:53:00Z","timestamp":1777672380017,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["HIM J"],"published-print":{"date-parts":[[2025,5]]},"abstract":"\n Background:<\/jats:title>\n Hospital-acquired complications (HACs) have an adverse impact on patient recovery by impeding their path to full recovery and increasing healthcare costs.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n The aim of this study was to create a HAC risk prediction machine learning (ML) framework using hospital administrative data collections within North Metropolitan Health Service (NMHS), Western Australia.<\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n A retrospective cohort study was performed among 64,315 patients between July 2020 to June 2022 to develop an automated ML framework by inputting HAC and the healthcare site to obtain site-specific predictive algorithms for patients admitted to the hospital in NMHS. Univariate analysis was used for initial feature screening for 270 variables. Of these, 77 variables had significant relationship with any HAC. After excluding non-contemporaneous data, 37 variables were included in developing the ML framework based on logistic regression (LR), decision tree (DT) and random forest (RF) models to predict occurrence of four specific HACs: delirium, aspiration pneumonia, pneumonia and urinary tract infection.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n All models exhibited similar performance with area under the curve scores around 0.90 for both training and testing datasets. For sensitivity, DT and RF exceeded LR performance while on average, false positives were lowest for LR-based models. Patient\u2019s length of stay, Charlson Index, operation length and intensive care unit stay were common predictors.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Integrating ML-based risk detection systems into clinical workflows can potentially enhance patient safety and optimise resource allocation. LR-based models exhibited best performance.<\/jats:p>\n <\/jats:sec>\n \n Implications:<\/jats:title>\n We have successfully developed a \u201creal-time\u201d risk prediction model, where patient risk scores are calculated and reviewed daily.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/18333583241256048","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T06:28:30Z","timestamp":1721888910000},"page":"109-120","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictive analytics for early detection of hospital-acquired complications: An artificial intelligence approach"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-244X","authenticated-orcid":false,"given":"Syed Aqif","family":"Mukhtar","sequence":"first","affiliation":[{"name":"Government of Western Australia, Australia"},{"name":"Curtin University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-5374","authenticated-orcid":false,"given":"Benjamin R","family":"McFadden","sequence":"additional","affiliation":[{"name":"University of Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0738-820X","authenticated-orcid":false,"given":"Md Tauhidul","family":"Islam","sequence":"additional","affiliation":[{"name":"Murdoch University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3073-9933","authenticated-orcid":false,"given":"Qiu Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Macquarie University Business School, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9258-1006","authenticated-orcid":false,"given":"Ehsan","family":"Alvandi","sequence":"additional","affiliation":[{"name":"The University of Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippa","family":"Blatchford","sequence":"additional","affiliation":[{"name":"Government of Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6793-0723","authenticated-orcid":false,"given":"Samantha","family":"Maybury","sequence":"additional","affiliation":[{"name":"Government of Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Blakey","sequence":"additional","affiliation":[{"name":"Curtin University, Australia"},{"name":"University of Western Australia, Australia"},{"name":"Sir Charles Gairdner Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0067-5907","authenticated-orcid":false,"given":"Pammy","family":"Yeoh","sequence":"additional","affiliation":[{"name":"Government of Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendon C","family":"McMullen","sequence":"additional","affiliation":[{"name":"Government of Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.31449\/inf.v45i1.3111"},{"key":"e_1_3_4_3_1","unstructured":"Australian Council on Healthcare Standards (ACHS) (2023) Hospital-acquired complications (HACs) Australian Commission on Safety and Quality in Healthcare. Available at: https:\/\/www.safetyandquality.gov.au\/our-work\/indicators\/hospital-acquired-complications (accessed 31 May 2023)."},{"key":"e_1_3_4_4_1","unstructured":"Australian Institute of Health and Welfare (AIHW) (2020) Australia\u2019s hospitals at a glance 2018\u201319 Australian Institute of Health and Welfare. Cat. no. HSE 247. Canberra: AIHW. Available at: https:\/\/www.aihw.gov.au\/reports\/hospitals\/australias-hospitals-at-a-glance-2018-19\/summary (accessed 13 July 2023)."},{"key":"e_1_3_4_5_1","unstructured":"Australian Institute of Health and Welfare (AIHW) (2023) Admitted patient care 2021\u201322: Safety and quality of the health systems (Table 8.8). 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Amsterdam, The Netherlands: Elsevier."},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biodatasci-092820-033938"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2018.03.022"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocaa267"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.3763"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.08.001"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.06.013"},{"key":"e_1_3_4_19_1","unstructured":"Independent Health and Aged Care Pricing Authority (IHACPA) (2020) Pricing and funding for safety and quality: Risk adjusted model for hospital acquired complications Independent Health and Aged Care Pricing Authority. National Efficient Price Determination 2020\u201321. Available at: https:\/\/www.ihacpa.gov.au\/sites\/default\/files\/2022-02\/Pricing%20and%20funding%20for%20safety%20and%20quality%20-%20HACs.pdf."},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/668422"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7100322"},{"issue":"1","key":"e_1_3_4_22_1","first-page":"50","article-title":"Predictive modeling: No crystal ball but an important tool. A relatively new application in health care holds promise of better care, lower costs","volume":"45","author":"LeGrow GS","year":"2004","unstructured":"LeGrow GS (2004) Predictive modeling: No crystal ball but an important tool. A relatively new application in health care holds promise of better care, lower costs. Healthplan 45(1): 50\u201353.","journal-title":"Healthplan"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmedt.2022.926667"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90002-0"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08535-y"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fdgth.2023.1260602"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-021-00373-4"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248636"},{"key":"e_1_3_4_29_1","author":"NMHS","year":"2023","unstructured":"NMHS (2023a) Internal Report, North Metropolitan Health Services. 1 June. NMHS database.","journal-title":"Internal Report, North Metropolitan Health Services"},{"key":"e_1_3_4_30_1","unstructured":"NMHS (2023b) North Metropolitan Health Service Annual Report 2022\u20132023. North Metropolitan Health Service. Available at: https:\/\/www.nmhs.health.wa.gov.au\/~\/media\/HSPs\/NMHS\/Documents\/Reports\/NMHS-Annual-Report-2023.pdf."},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2020.03.002"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.icte.2023.02.007"},{"key":"e_1_3_4_33_1","first-page":"32","author":"Roelofs R","year":"2019","unstructured":"Roelofs R, Shankar V, Recht B, et al. (2019) A meta-analysis of overfitting in machine learning. In: Wallach H, Larochelle H, Beygelzimer A et al. (eds) Advances in Neural Information Processing Systems, p. 32.","journal-title":"Advances in Neural Information Processing Systems"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2023.03.018"},{"key":"e_1_3_4_35_1","doi-asserted-by":"crossref","unstructured":"Schubert A Kemmerly SA (eds.) (2022) Optimizing Widely Reported Hospital Quality and Safety Grades: An Ochsner Quality and Value Playbook. Cham: Springer International Publishing. Available at: https:\/\/link.springer.com\/10.1007\/978-3-031-04141-9 (accessed 31 May 2023).","DOI":"10.1007\/978-3-031-04141-9"},{"key":"e_1_3_4_36_1","doi-asserted-by":"crossref","unstructured":"Slawomirski L Auraaen A Klazinga NS (2017) The economics of patient safety: Strengthening a value-based approach to reducing patient harm at national level. OECD Health Working Papers No. 96 OECD Publishing Paris. https:\/\/doi.org\/10.1787\/5a9858cd-en.","DOI":"10.1787\/5a9858cd-en"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2021.104484"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-022-07895-6"},{"key":"e_1_3_4_39_1","unstructured":"WHO (2023) Patient safety World Health Organization. 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Journal"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/18333583241256048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/18333583241256048","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/18333583241256048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:04:42Z","timestamp":1777449882000},"score":7.6732774,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/18333583241256048"}},"issued":{"date-parts":[[2024,7,25]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/18333583241256048"],"URL":"https:\/\/doi.org\/10.1177\/18333583241256048","ISSN":["1833-3583","1833-3575"],"issn-type":[{"value":"1833-3583","type":"print"},{"value":"1833-3575","type":"electronic"}],"published":{"date-parts":[[2024,7,25]]}},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:42:07Z","timestamp":1651210927688},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.juro.2017.02.2569","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T18:29:06Z","timestamp":1491244146000},"source":"Crossref","is-referenced-by-count":0,"title":["MP83-01 HIGH-GRADE PROSTATE CANCER HAS INCREASED MITOCHONDRIAL CONTENT"],"prefix":"10.1097","volume":"197","author":[{"given":"Anton","family":"Kalsbeek","sequence":"first","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Chan","sequence":"additional","affiliation":[{"name":"Sydney, 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Menang\/Merningar Boodja was attended by 191 people in May 2024. The three\u2010day symposium prioritised Indigenous voices and brought together all collaborators on the two\u2010way science research project, Walking Together,<\/jats:italic> as well as other cross\u2010cultural ecology researchers, educators and practitioners from across Australia. Presenters included Noongar, Martu, Gamilaroi, Kaurareg and Yamaji traditional custodians, Indigenous rangers and representatives of research, education, health, local government, emergency management, conservation, Native Title and not\u2010for\u2010profit organisations. It was an opportunity to learn from and inspire one another, to celebrate achievements, and to collectively workshop next steps in cross\u2010cultural approaches to care for Country, culture and people. Strong themes of the workshop were that successful two\u2010way caring for Country requires robust collaborative relationships and is usually highly place\u2010based in nature, neither of which are well\u2010supported by short\u2010term and scarce funding programmes. New approaches to supporting Indigenous\u2010led, collaborative conservation work are required.<\/jats:p>","DOI":"10.1111\/emr.70024","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T12:20:03Z","timestamp":1757506803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Collaborating (Not Consulting) to Care for Country: Kwodjet Goorliny<\/i> Symposium, Kinjaarliny\/Albany, Western Australia, May 2024"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7712-1674","authenticated-orcid":false,"given":"Alison","family":"Lullfitz","sequence":"first","affiliation":[{"name":"University of Western Australia Albany Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shandell","family":"Cummings","sequence":"additional","affiliation":[{"name":"University of Western Australia Albany Western Australia Australia"},{"name":"NESP Resilient Landscapes Hub, School of Agriculture and Environment University of Western Australia Albany Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessikah","family":"Woods","sequence":"additional","affiliation":[{"name":"University of Western Australia Albany Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5976-9645","authenticated-orcid":false,"given":"Ursula","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"University of Western Australia Albany Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susannah","family":"Cramp","sequence":"additional","affiliation":[{"name":"University of Western Australia Albany Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-2856","authenticated-orcid":false,"given":"Stephen D.","family":"Hopper","sequence":"additional","affiliation":[{"name":"University of Western Australia Albany Western Australia Australia"},{"name":"School of Biological Sciences University of Western Australia Albany Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/10778004211068192"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1474474014539248"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/emr.12534"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1071\/PC25004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1834-4453.2001.tb00469.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-8903.2011.00634.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/emr.12539"},{"key":"e_1_2_11_9_1","volume-title":"Song Spirals, Sharing Women's Wisdom of Country Through Songlines","author":"Gay'wu Group of Women","year":"2019"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11104-009-0068-0"},{"key":"e_1_2_11_11_1","unstructured":"Ischenko A.2023.\u201c\u201cThis Is Wiirn Yiert Our Spiritual Pathway\u201d: Modelling Noongar Travel Routes to Rediscover Water Trees in Southwest Australia.\u201dMaster of Environmental Science thesis UWA."},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1071\/PC24018"},{"key":"e_1_2_11_13_1","first-page":"50","volume-title":"Eucalyptus","author":"Knapp L.","year":"2025"},{"key":"e_1_2_11_14_1","unstructured":"Lullfitz A.2019.\u201cVegetation Responses to Noongar Land Management in Old and Young Landscapes of Southwestern Australia.\u201dPhD thesis University of Western Australia."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11104\u2010023\u201006057\u20109"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolinnean\/blaa097"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/emr.12532"},{"key":"e_1_2_11_18_1","unstructured":"Putnis A. P.Josif andE.Woodward.2007.\u201cHealthy Country Healthy People Investment Strategy.\u201dFinal Report October 2007. The Commonwealth Scientific and Industrial Research Organisation (CSIRO)."},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10745\u2010022\u201000359\u20109"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/15595692.2024.2387368"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41559\u2010023\u201001994\u20101"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/13504622.2020.1773407"}],"container-title":["Ecological Management & Restoration"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/emr.70024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T05:51:58Z","timestamp":1758865918000},"score":7.6730094,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/emr.70024"}},"issued":{"date-parts":[[2025,9]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/emr.70024"],"URL":"https:\/\/doi.org\/10.1111\/emr.70024","archive":["Portico"],"ISSN":["1442-7001","1442-8903"],"issn-type":[{"value":"1442-7001","type":"print"},{"value":"1442-8903","type":"electronic"}],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70024"},{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:53:07Z","timestamp":1768265587374,"version":"3.49.0"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000960","name":"Healthway","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000960","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Infant Mental Health Journal: Infancy and Early Childhood"],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract<\/jats:title>\n \n The capacity for children to self\u2010regulate is an important developmental task of early childhood, with caregivers playing an integral role in self\u2010regulation development. While caregivers\u2019 emotions and behaviors are known to impact child self\u2010regulatory capacity, the impact of child self\u2010regulation difficulties on parents is less understood. This study explored parents\u2019 experience of child self\u2010regulation difficulties using semi\u2010structured qualitative interviews with 23 parents (87% female; 90% European Australian;\n M<\/jats:italic>\n age\u00a0=\u00a035.95) of children (aged 5 years and under) in Australia. Five key themes were identified through thematic analysis: \u2018supporting child self\u2010regulation is hard\u2019, \u2018takes a toll on parents\u2019, \u2018challenging for parents to self\u2010regulate\u2019, \u2018relationships change\u2019, and \u2018daily life needs to change\u2019. This research highlights the need for programs that support parents with children experiencing self\u2010regulation difficulties.\n <\/jats:p>","DOI":"10.1002\/imhj.70062","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T01:00:51Z","timestamp":1767056451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of child self\u2010regulation difficulties on parents: A qualitative study"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4695-762X","authenticated-orcid":false,"given":"Charlotte","family":"Fox","sequence":"first","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"},{"name":"Health and Social Care Unit, School of Public Health and Preventative Medicine Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeneva L.","family":"Ohan","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"},{"name":"The University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaida","family":"Penny","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Wells","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Downs","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Brinkman","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Finlay\u2010Jones","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"},{"name":"Curtin University Bentley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101754.2007.01005.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u20108624.2009.01397.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/children10081323"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"e_1_2_9_6_1","first-page":"229","volume-title":"Handbook of Emotion Regulation","author":"Calkins S. 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R.","year":"1982"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10488\u2010013\u20100528\u2010y"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.4324\/9781351001328-1"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102648.2008.04853.x"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.16586"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/1054773816682331"},{"key":"e_1_2_9_48_1","unstructured":"Qualtrics. (2024).Qualtrics(Version February 2023).https:\/\/www.qualtrics.com"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/7.4.379"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719003593"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/14780880802699092"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cedpsych.2023.102200"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecresq.2018.02.014"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101754.2007.01060.x"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/15402002.2017.1357118"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/imhj.21685"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482631.2018.1527605"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.1991"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/001440290807400406"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1037\/dev0000556"}],"container-title":["Infant Mental Health Journal: Infancy and Early Childhood"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/imhj.70062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/imhj.70062","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/imhj.70062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T15:55:58Z","timestamp":1768233358000},"score":7.672969,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/imhj.70062"}},"issued":{"date-parts":[[2025,12,29]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/imhj.70062"],"URL":"https:\/\/doi.org\/10.1002\/imhj.70062","archive":["Portico"],"ISSN":["0163-9641","1097-0355"],"issn-type":[{"value":"0163-9641","type":"print"},{"value":"1097-0355","type":"electronic"}],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"2024-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70062"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:09Z","timestamp":1753889769883,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Stroke is a leading cause of death and permanent disability. Type 2 diabetes (T2D) increases the incidence of stroke by four-fold and is a strong predictor of worse outcome following stroke with greater disability and mortality than in nondiabetics. While the reasons for increased stroke severity in T2D are unclear, we hypothesized that T2D alters the cerebral vascular response to ischemic stroke leading to reduced vascular reperfusion and hence greater infarct following restoration of blood flow post-stroke. To address this hypothesis, 15-week-old male Sprague Dawley rats were given a high fat diet and treated with osmotic-mini pump infused STZ (110mg\/kg over 14 days) to develop a mild T2D phenotype, characterized by obesity and glucose of 8-10mM. Normal chow-fed aged matched rats were used as controls. Four weeks after induction of T2D, we quantified cerebral perfusion in real-time using contrast enhanced ultrasound (CEU) before, during and immediately after middle cerebral artery occlusion, the gold standard model of ischemic stroke. Following this, rats were allowed to recover and a battery of behavioral tests was used to assess stroke severity over 14 days. A final CEU measure was obtained 14 days post-stroke to track vascular changes over time. Cerebral perfusion tended to be increased in T2D rats at baseline but was similarly reduced during middle cerebral artery occlusion. Strikingly, T2D rats had a 3-fold increase in cerebral perfusion immediately post-stroke and this hyperperfusion was sustained 14 days post-stroke. Importantly, although there was no difference in behavior at baseline or immediately following stroke, by day 6, T2D rats developed a greater level of disability compared with control rats that was sustained until day 14.<\/jats:p>\n In conclusion, we demonstrate that T2D alters the cerebral vascular response to ischemic stroke, leading to severe vascular hyperperfusion and that this is associated with a greater level of disability in rats.<\/jats:p>\n \n Disclosure<\/jats:title>\n C.D. Ramsay: None. D.W. Howells: None. M. Keske: None. B. Sutherland: None. D. Premilovac: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-1814-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T01:42:07Z","timestamp":1559698927000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1814-P: Type 2 Diabetes Increases Stroke Severity through Sustained Hyperperfusion of Cerebral Vasculature following Ischemic Stroke in Rats"],"prefix":"10.2337","volume":"68","author":[{"given":"CIARAN DAVID","family":"RAMSAY","sequence":"first","affiliation":[{"name":"Hobart, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID W.","family":"HOWELLS","sequence":"additional","affiliation":[{"name":"Hobart, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHELLE","family":"KESKE","sequence":"additional","affiliation":[{"name":"Hobart, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRAD","family":"SUTHERLAND","sequence":"additional","affiliation":[{"name":"Hobart, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DINO","family":"PREMILOVAC","sequence":"additional","affiliation":[{"name":"Hobart, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1814-P\/59122\/1814-P-Type-2-Diabetes-Increases-Stroke-Severity","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1814-P\/59122\/1814-P-Type-2-Diabetes-Increases-Stroke-Severity","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:05:56Z","timestamp":1647165956000},"score":7.6713343,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1814-P\/59122\/1814-P-Type-2-Diabetes-Increases-Stroke-Severity"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-1814-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"1814-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:37Z","timestamp":1753889857493,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,6,14]]},"abstract":"Introduction: It is unclear whether exercise in cool water, typical of many popular beaches, increases the risk of hypoglycaemia in individuals with type one diabetes mellitus (T1DM).<\/jats:p>\n Objective: To test the hypothesis that exercise in cool water results in a greater decrease in blood glucose concentration than does exercise in thermoneutral water or on land in individuals with T1DM.<\/jats:p>\n Methods: Eight overnight-fasted individuals (aged 18 to 40 years) with T1DM completed 3 x 60-min cycling sessions on an ergometer at 40% of their on-land V\u0307O2peak under the following conditions; while immersed in cool water (22\u00b0C), in thermoneutral water (32\u00b0C) or on land at thermoneutrality (22\u00b0C). At regular time intervals, the following variables were measured: concentration of blood glucose and plasma insulin, skin blood flow and skin temperature, and rate of carbohydrate and fat oxidation.<\/jats:p>\n Results: Blood glucose concentration did not change during cycling in cool or thermoneutral water (p&gt;0.05), but decreased during cycling on land (p&lt;0.05). During 60 minutes of on-land recovery at 24\u00b0C after cycling in cool water, blood glucose concentration increased significantly (~2 mmol\/L, p&lt;0.05), but not after cycling in thermoneutral water or on-land. The concentration of plasma insulin decreased during and early after cycling in cool water (p&lt;0.05).<\/jats:p>\n Conclusion: Exercise in cool water in people with type 1 diabetes mellitus does not cause a greater decrease in blood glucose concentration than does exercise in thermoneutral water or on land, but increases blood glucose early during on-land recovery probably as a result of a transient decrease in plasma insulin concentration.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n K. Abramoff: None. S.K. Maloney: None. T. Jones: None. E.A. Davis: None. P.A. Fournier: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db24-327-or","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T05:43:07Z","timestamp":1718343787000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["327-OR: Does Exercise in Cool Water Result in a Greater Decrease in Blood Glucose Concentration than Exercise in Thermoneutral Water or on Land in People with Type 1 Diabetes?"],"prefix":"10.2337","volume":"73","author":[{"given":"KRISTINA","family":"ABRAMOFF","sequence":"first","affiliation":[{"name":"Crawley, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHANE K.","family":"MALONEY","sequence":"additional","affiliation":[{"name":"Crawley, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIM","family":"JONES","sequence":"additional","affiliation":[{"name":"Crawley, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH A.","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Crawley, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL A.","family":"FOURNIER","sequence":"additional","affiliation":[{"name":"Crawley, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/327-OR\/155516\/327-OR-Does-Exercise-in-Cool-Water-Result-in-a","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/327-OR\/155516\/327-OR-Does-Exercise-in-Cool-Water-Result-in-a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T05:43:08Z","timestamp":1718343788000},"score":7.6713343,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/327-OR\/155516\/327-OR-Does-Exercise-in-Cool-Water-Result-in-a"}},"issued":{"date-parts":[[2024,6,14]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2024,6,14]]}},"URL":"https:\/\/doi.org\/10.2337\/db24-327-or","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2024,6,14]]},"article-number":"327-OR"},{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:23:27Z","timestamp":1774617807016,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australas J Ageing"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n This study evaluated the quality and quantity of Goals of Patient Care (GoPC) documentation amongst older adults admitted under General Surgery at a tertiary hospital, comparing standards before and after integration of proactive geriatric medicine input via the Older Adult Surgical Inpatient Service (OASIS).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective audit was performed of older adults discharged from General Surgery over a 6\u2010month period. Quantity was defined as total number and percentage of patients with documented GoPC. Quality was defined as time from admission to completion and rate of documentation of patient preferences. Service impact was explored via the specialty team authorising the GoPC form and the ceiling of care identified.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In total, 526 patient care episodes were included pre\u2010OASIS and 532 post\u2010OASIS. Of these, 50 patients (10%) had completed GoPC forms pre\u2010OASIS, increasing to 139 patients (26%) post\u2010OASIS (\n p<\/jats:italic>\n \u2009<\u20090.001). Completion within 48\u2009h of admission improved from 22 patients (44%) pre\u2010OASIS to 97 patients (70%) post\u2010OASIS. Inclusion of patient preferences increased from 39 (78%) to 102 (73%;\n p<\/jats:italic>\n \u2009=\u20090.65). The Older Adult Surgical Inpatient Service completed 88 (63%) of GoPC forms in the relevant cohort, though completion by the surgical team remained unchanged (29 pre\u2010OASIS vs. 30 post\u2010OASIS). There was an almost twofold increase in the number of patients with GoPC \u2018not for CPR\u2019 (47 vs. 102).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Goals of Patient Care document completion for older adults admitted to General Surgery are below that recommended by local hospital policy. With the initiation of OASIS, there was a significant improvement in the quantity and quality of GoPC documentation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ajag.70146","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:21:41Z","timestamp":1773292901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Initiating the Older Adult Surgical Inpatient Service on the Quantity and Quality of Goals of Patient Care Documentation"],"prefix":"10.1111","volume":"45","author":[{"given":"Anuttara Panchali W.","family":"Kumarasinghe","sequence":"first","affiliation":[{"name":"Fiona Stanley Hospital Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"},{"name":"Curtin University Perth Western Australia 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In this study, we assess regional vulnerability to GICs by modeling the geoelectric fields induced by significant historic geomagnetic disturbance events in the presence of 3D subsurface geology using data from the Australian Lithospheric Architecture Magnetotelluric Project (AusLAMP) magnetotelluric array, Australia\u2010Wide Array of Geomagnetic Stations (AWAGS) magnetometer array, and Geoscience Australia geomagnetic observatory network. We analyze the vertical component of the magnetic field with respect to the horizontal magnetic\u2010field polarization for two magnetic storms and gain insight into the inductive effects associated with field polarization orientations in the 3D case. We also analyze the telluric field intensity and polarization for a unit geomagnetic field polarized in northerly and easterly directions at AusLAMP sites and find that in the presence of 3D geology the induced field has a very polarization\u2010sensitive anomaly. We model the geoelectric fields in southeastern Australia for the 1989 \u201cQu\u00e9bec storm.\u201d The induced ground electric fields are typically in the range 1,000\u20132,000\u00a0mV\/km with a few sites within 2,000\u20135,000\u00a0mV\/km on highly resistive regions and in coastal areas, and below 300\u00a0mV\/km on inland sedimentary basins. The current study focuses on magnetic\u2010field variations with periods between 120 and ~20,000\u00a0s due to bandwidth limits in our magnetotelluric tensor data and the Nyquist limit for the 60\u00a0s sampling of our geomagnetic\u2010field data. Hence, our modeled maximum values should be considered lower estimates of potential real values.<\/jats:p>","DOI":"10.1029\/2020jb019843","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T12:29:03Z","timestamp":1598617743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Modeling Geoelectric Fields Induced by Geomagnetic Disturbances in 3D Subsurface Geology, an Example From Southeastern Australia"],"prefix":"10.1029","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2980-1886","authenticated-orcid":false,"given":"Liejun","family":"Wang","sequence":"first","affiliation":[{"name":"Geoscience Australia Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingming","family":"Duan","sequence":"additional","affiliation":[{"name":"Geoscience Australia Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian P.","family":"Hitchman","sequence":"additional","affiliation":[{"name":"Geoscience Australia Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Geoscience Australia Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William V.","family":"Jones","sequence":"additional","affiliation":[{"name":"Geoscience Australia Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"13","published-online":{"date-parts":[[2020,9,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/BF03352247"},{"key":"e_1_2_11_3_1","unstructured":"Australian Energy Market Operator(2017).Black System South Australia 28 September 2016.https:\/\/www.aemo.com.au\/-\/media\/Files\/Electricity\/NEM\/Market_Notices_and_Events\/Power_System_Incident_Reports\/2017\/Integrated-Final-Report-SA-Black-System-28-September-2016.pdf"},{"key":"e_1_2_11_4_1","first-page":"119","article-title":"Interpretation of the magnetotelluric impedance tensor: Regional induction and local telluric distortion","volume":"62","author":"Bahr K.","year":"1988","journal-title":"Journal of Geophysics"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","unstructured":"Bartlett S.(2016).Trans\u2010Australian HVDC interconnection investigation.Paper presented at 2016 IEEE PES Asia\u2010Pacific Power and Energy Engineering Conference Xi'an China.https:\/\/doi.org\/10.1109\/APPEEC.2016.7779587","DOI":"10.1109\/APPEEC.2016.7779587"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6826(02)00127-X"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-246X.2004.02376.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/2015GL066636"},{"key":"e_1_2_11_9_1","first-page":"108","volume-title":"Operating the Hydro\u2010Qu\u00e9bec grid under storm conditions since the storm of 13 March 1989","author":"Blais G.","year":"1993"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.22459\/SN.08.2012"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/2016SW001535"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-246x.1998.00588.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1029\/2019SW002278"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1190\/1.1437915"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1029\/2018SW001999"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9201(85)90050-0"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1071\/EG986031"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1029\/90EO00376"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9201(99)00126-0"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tecto.2013.05.038"},{"key":"e_1_2_11_21_1","doi-asserted-by":"crossref","unstructured":"Duan J. &Kyi D.(2018).Australian Lithospheric Architecture Magnetotelluric Project (AusLAMP): Victoria Data Release Report (Technical Report). 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We thus conducted a systematic review and network meta-analysis to compare and rank the efficacy and safety of technologies for the treatment of type 1 diabetes.<\/jats:p>\n Methods: We searched MEDLINE, MEDLINE In-Process and other non-indexed citations, EMBASE, PubMed, All Evidenced Based Medicine Reviews, Web of Science, PsycINFO, CINAHL and PROSPERO. We included RCTs \u22656 weeks duration comparing technologies among non-pregnant adults (\u226518 years of age). We assessed risk of bias using a validated tool and certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation framework. Primary outcomes were HbA1c, rates of severe and non-severe hypoglycemia, and quality of life.<\/jats:p>\n Findings: We identified 15,691 publications of which 50 eligible studies compared 12 technologies, with 3,885 participants. Integrated insulin pump and continuous glucose monitoring (CGM) systems resulted in HbA1c levels 0\u00b795% (95% predictive interval 0\u00b702-1\u00b787) and 0\u00b786% (0\u00b710-1\u00b761) lower than multiple daily injections (MDI) with either flash glucose monitoring or capillary glucose testing, respectively. Integrated systems also had the best overall ranking for HbA1c reduction. MDI with flash glucose monitoring was ranked as the best treatment for prevention of non-severe hypoglycemia with event rates significantly lower than any other intervention. The best treatment rankings for severe hypoglycemia and quality of life were MDI with flash glucose monitoring and CGM, respectively. The overall risk of bias rating was moderate-high for all outcomes. The certainty of evidence was very low.<\/jats:p>\n Interpretation: Integrated insulin pump and CGM systems appeared superior for lowering HbA1c while glucose sensing devices appeared superior for preventing hypoglycaemia and improving quality of life.<\/jats:p>\n \n Disclosure<\/jats:title>\n A.J. Pease: None. C. Lo: None. A. Earnest: None. V. Kiriakova: None. D. Liew: Advisory Panel; Self; AstraZeneca, Bayer AG. Research Support; Self; AbbVie Inc., AstraZeneca, Bristol-Myers Squibb Company, CSL Behring, Pfizer Inc. S. 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Our framework allows for equational reasoning about systems code written in our new language, Cogent. Cogent is a restricted, polymorphic, higher-order, and purely functional language with linear types and without the need for a trusted runtime or garbage collector. Linear types allow us to assign two semantics to the language: one imperative, suitable for efficient C code generation; and one functional, suitable for equational reasoning and verification. As Cogent is a restricted language, it is designed to easily interoperate with existing C functions and to connect to existing C verification frameworks. Our framework is based on certifying compilation: For a well-typed Cogent program, our compiler produces C code, a high-level shallow embedding of its semantics in Isabelle\/HOL, and a proof that the C code correctly refines this embedding. 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Abstracts"],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1071\/ASEG2004ab078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T20:02:13Z","timestamp":1777060933000},"score":7.670174,"resource":{"primary":{"URL":"https:\/\/www.earthdoc.org\/content\/journals\/10.1071\/ASEG2004ab078"}},"issued":{"date-parts":[[2004,12,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,12,1]]}},"URL":"https:\/\/doi.org\/10.1071\/aseg2004ab078","ISSN":["2202-0586"],"issn-type":[{"value":"2202-0586","type":"print"}],"published":{"date-parts":[[2004,12,1]]}},{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T09:52:56Z","timestamp":1773568376945,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"10S","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.arthro.2011.08.152","type":"journal-article","created":{"date-parts":[[2011,10,15]],"date-time":"2011-10-15T14:20:32Z","timestamp":1318688432000},"source":"Crossref","is-referenced-by-count":1,"title":["Paper # 152: Five Year Clinical and Radiological Evaluation of Matrix\u2010Induced Autologous Chondrocyte Implantation (MACI)"],"prefix":"10.1002","volume":"27","author":[{"given":"Jay Robert","family":"Ebert","sequence":"first","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fallon","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Robertson","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Ackland","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming Hao","family":"Zheng","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Janes","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Wood","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,1]]},"container-title":["Arthroscopy"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806311008620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806311008620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2011.08.152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2011.08.152","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2011.08.152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T08:50:18Z","timestamp":1773564618000},"score":7.669961,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2011.08.152"}},"issued":{"date-parts":[[2011,10]]},"references-count":0,"journal-issue":{"issue":"10S","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1016\/j.arthro.2011.08.152"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2011.08.152","archive":["Portico"],"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"published":{"date-parts":[[2011,10]]}},{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:48:13Z","timestamp":1784832493655,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2024,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Machine learning may assist with the identification of potentially inappropriate penicillin allergy labels. Strategies to improve the performance of existing models for this task include the use of additional training data, synthetic data and transfer learning.<\/jats:p><\/jats:sec>Aims<\/jats:title>The aims of this study were to investigate the use of additional training data and novel machine learning strategies, namely synthetic data and transfer learning, to improve the performance of penicillin adverse drug reaction (ADR) machine learning classification.<\/jats:p><\/jats:sec>Methods<\/jats:title>Machine learning natural language processing was applied to free\u2010text penicillin ADR data extracted from a public health system electronic health record (EHR). The models were developed by training on various labelled data sets. ADR entries were split into training and testing data sets and used to develop and test a variety of machine learning models. The effect of training on additional data and synthetic data versus the use of transfer learning was analysed.<\/jats:p><\/jats:sec>Results<\/jats:title>Following the application of these techniques, the area under the receiver operator curve of best\u2010performing models for the classification of penicillin allergy (vs intolerance) and high\u2010risk allergy (vs low\u2010risk allergy) improved to 0.984 (using the artificial neural network model) and 0.995 (with the transfer learning approach) respectively.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Machine learning models demonstrate high levels of accuracy in the classification and risk stratification of penicillin ADR labels using the reaction documented in the EHR. The model can be further optimised by incorporating additional training data and using transfer learning. Practical applications include automating case detection for penicillin allergy delabelling programmes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.16360","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T11:14:47Z","timestamp":1710414887000},"page":"1183-1189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Improving the performance of machine learning penicillin adverse drug reaction classification with synthetic data and transfer learning"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2003-0843","authenticated-orcid":false,"given":"Viera","family":"Stanekova","sequence":"first","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0486-9013","authenticated-orcid":false,"given":"Joshua M.","family":"Inglis","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Lam","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"Lam","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Smith","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepehr","family":"Shakib","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5130-8628","authenticated-orcid":false,"given":"Stephen","family":"Bacchi","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2021-005437"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa653"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.9820"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.12.033"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2021.104611"},{"key":"e_1_2_6_7_1","first-page":"12","article-title":"Adverse drug reactions: allergy? Side\u2010effect? Intolerance","volume":"42","author":"Smith W","year":"2013","journal-title":"Aust Fam Physician"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00751-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","unstructured":"MokriiI BoytsovL BraslavskiP.A systematic evaluation of transfer learning and pseudo\u2010labeling with BERT\u2010based ranking models. Proceedings of the 44th International ACM SIGIR Conference on Research and Development in Information Retrieval; 2021 pp. 2081\u20132085.","DOI":"10.1145\/3404835.3463093"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13558"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.07.048"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16266"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.550"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-021-00455-y"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028019860521"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.028"}],"container-title":["Internal Medicine Journal"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.16360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T02:09:22Z","timestamp":1721182162000},"score":7.6698837,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.16360"}},"issued":{"date-parts":[[2024,3,14]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/imj.16360"],"URL":"https:\/\/doi.org\/10.1111\/imj.16360","archive":["Portico"],"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"published":{"date-parts":[[2024,3,14]]},"assertion":[{"value":"2023-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:57:21Z","timestamp":1784674641777,"version":"3.55.0"},"reference-count":47,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T00:00:00Z","timestamp":1342137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Hum Lact"],"published-print":{"date-parts":[[2013,2]]},"abstract":"\n Background:<\/jats:title>\n Data regarding the association between breast milk composition and infant feeding patterns (frequency and amount of breast milk taken) would help in understanding the regulation of food intake in breastfed infants.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n This study examined the relationship between breast milk macronutrient concentration and patterns of milk intake in breastfeeding infants over a 24-hour breastfeeding period.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Mothers of healthy term infants (n = 15) collected pre- and postfeed breast milk samples from each feed at each breast over a 24-hour period. Breast milk samples were analyzed for fat, lactose, total protein, casein, and whey protein content. The energy content for each feed was calculated.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Breastfeeding patterns and milk composition varied greatly between individuals. The fat content of milk significantly differed over 24 hours ( P = .01), whereas the concentration of lactose and protein content remained the same. The mean 24-hour total protein, whey, and casein intake was inversely ( P < .01), whereas lactose concentration was positively ( P = .03) related to the number of breast feeds per day. No relationship was seen either between fat or energy content and feeding patterns. The mean (SD) concentration of fat, lactose, and total protein over the 24-hour period was 43 (12) g\/L, 68 (7) g\/L, and 13 (2) g\/L, respectively.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The association between milk protein intake and the breastfeeding frequency suggests that the protein intake may play a role in infant appetite control.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/0890334412448841","type":"journal-article","created":{"date-parts":[[2012,7,15]],"date-time":"2012-07-15T19:54:55Z","timestamp":1342382095000},"page":"81-89","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":129,"title":["Variation in Fat, Lactose, and Protein Composition in Breast Milk over 24 Hours"],"prefix":"10.1177","volume":"29","author":[{"given":"Sadaf","family":"Khan","sequence":"first","affiliation":[{"name":"The University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna R.","family":"Hepworth","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle K.","family":"Prime","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching T.","family":"Lai","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi J.","family":"Trengove","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Hartmann","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,7,13]]},"reference":[{"key":"bibr1-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1417"},{"key":"bibr2-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1159\/000066498"},{"key":"bibr3-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198302030-00018"},{"key":"bibr4-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1993.sp003681"},{"key":"bibr5-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1986.tb10313.x"},{"key":"bibr6-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420230606"},{"key":"bibr7-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/48.6.1375"},{"key":"bibr8-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80189-3"},{"key":"bibr9-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(82)90108-6"},{"key":"bibr10-0890334412448841","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1152\/ajpcell.1980.239.1.C1","volume":"239","author":"Hunt JN","year":"1980","journal-title":"Am J Physiol"},{"key":"bibr11-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601373"},{"key":"bibr12-0890334412448841","first-page":"15P","volume":"175","author":"Fleet IR","year":"1964","journal-title":"J Physiol"},{"key":"bibr13-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4358-4-3"},{"key":"bibr14-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2002579"},{"key":"bibr15-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198911000-00016"},{"key":"bibr16-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31824cf386"},{"key":"bibr17-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/49.3.464"},{"key":"bibr18-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/51.1.37"},{"key":"bibr19-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1017\/S0022029900030569"},{"key":"bibr20-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012384430-9\/50010-X"},{"key":"bibr21-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198709000-00017"},{"key":"bibr22-0890334412448841","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1993.sp003722"},{"key":"bibr23-0890334412448841","unstructured":"R Development Core Team. 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Intervention characteristics such as intervention type, provider, delivery mode (individual, group or both), the use of theory, intervention location (home- or centre-based), duration, frequency, monitoring (supervised or unsupervised) and other characteristics have not been thoroughly investigated and likely impact intervention efficacy. This study was a systematic review and meta-analysis of controlled trials on lifestyle (diet and\/or exercise), metformin and dietary supplementation. The impact of intervention characteristics on GDM prevention was conducted using the \u2018Template for Intervention Description and Replication framework\u2019. Overall, 116 studies were included. For lifestyle interventions (n=92), lower risks of GDM were observed in studies with supervised sessions (n=13, RR 0.63, 95% CI 0.50-0.79, p=0.04) compared with those with unsupervised sessions, with group-only delivery (n= 17, RR 0.61, 95% CI 0.51-0.74, p=0.04) compared with those with a combination of individual and group delivery, and in low-middle income countries (n=7, RR 0.58 95% CI 0.42-0.8, p=0.03) compared with studies conducted in middle or high-income countries. Lifestyle intervention effect sizes did not differ by any other intervention characteristics. No significant effect of intervention characteristics was seen in metformin studies (n=13). For dietary supplementation studies (n=12), lower risks of GDM were observed with myoinositol (n=7, RR 0.38, 95% CI 0.23-0.65) but not with probiotics (n=5, RR 0.88, 95% CI 0.52-1.47). Country setting, delivery mode, session supervision may be important characteristics determining the effectiveness of GDM prevention. Further research is needed to tailor these intervention approaches for specific populations.<\/jats:p>\n \n Disclosure<\/jats:title>\n W.W.Takele: None. S.J.Zhou: None. R.Taylor: None. M.Pathirana: None. K.Liu: None. M.P.Bonham: None. M.Chen: None. A.J.Fawcett: None. S.C.Chivers: None. S.Lim: None. G.G.Ukke: None. J.L.Josefson: None. K.K.Vesco: Research Support; Pfizer Inc. L.M.Redman: Research Support; Dexcom, Inc., Abbott Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Stock\/Shareholder; ABGIL, Teladoc Health. J.A.Grieger: None. N.Habibi: None. A.Quinteros: None. G.Leung: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-659-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:46:21Z","timestamp":1687239981000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["659-P: The Effectiveness of Lifestyle, Metformin, or Dietary Supplements for the Prevention of Gestational Diabetes Mellitus (GDM) by Intervention Characteristics\u2014A Systematic Review and Meta-analysis"],"prefix":"10.2337","volume":"72","author":[{"given":"WUBET W.","family":"TAKELE","sequence":"first","affiliation":[{"name":"Clayton, Australia, Box Hill, Australia, Portland, OR, Baton Rouge, LA, Adelaide, Australia, Newcastle, Australia, Notting Hill, Australia, Melbourne, Australia, Chicago, IL, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GEBRESILASEA 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institution. Fusion was assessed at different time points in these patients by 2 independent musculoskeletal radiologists. Fusion was analyzed in coronal and sagittal planes using both imaging modalities, with confidence being attributed on a scale of 0 to 3. Assessors were blinded to patient data.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Fourteen patients (25 levels) with mean follow-up of 10.2 months (range 2.4-20.3 years) and age of 41 years (range 20.7-61.5 years) were assessed. MRI within the interbody cage in coronal (\u03ba = .58) and sagittal (\u03ba = .50) planes had the highest interobserver agreement. CT anterior to the cage in coronal (\u03ba = .48) and sagittal (\u03ba = .44) planes, as well as within the cage in coronal (\u03ba = .50) and sagittal planes (\u03ba = .44) showed moderate agreement. Confidence anterior to the interbody cage using MRI scan was reduced when compared with remaining angles and imaging modalities.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n The study demonstrates that MRI may be a useful tool in the assessment of fusion following ALIF with results comparable to CT, and that it may have a useful role in select patients especially considering marked radiation exposure reduction.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/2192568218757483","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T01:10:13Z","timestamp":1522113013000},"page":"586-592","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Fusion Assessment by MRI in Comparison With CT in Anterior Lumbar Interbody Fusion: A Prospective Study"],"prefix":"10.1177","volume":"8","author":[{"given":"David","family":"Kitchen","sequence":"first","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashanth J.","family":"Rao","sequence":"additional","affiliation":[{"name":"Neurospine Research Group, Adelaide, South Australia, Australia"},{"name":"Westmead Hospital, Westmead, Australia"},{"name":"University of Sydney, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-3914","authenticated-orcid":false,"given":"Mario","family":"Zotti","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Woodman","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Sampson","sequence":"additional","affiliation":[{"name":"Flinders 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"bibr1-2192568218757483","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/BLO.0b013e3180686a0f","volume":"460","author":"Albee FH","year":"2007","journal-title":"Clin Orthop Relat Res"},{"key":"bibr2-2192568218757483","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.jocn.2015.03.034","volume":"22","author":"Rao PJ","year":"2015","journal-title":"J Clin Neurosci"},{"key":"bibr3-2192568218757483","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00638889","volume":"13","author":"Stender W","year":"1990","journal-title":"Neurosurg Rev"},{"key":"bibr4-2192568218757483","first-page":"423","volume":"72","author":"Burke PJ","year":"2001","journal-title":"Radiol 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M","year":"2015","journal-title":"Clin Neurol Neurosurg"}],"container-title":["Global Spine 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While rates of victimization are significantly higher than non-Aboriginal rates, Aboriginal women remain suspicious of the \u2018carceral feminism\u2019 remedy, arguing that family violence is a legacy of colonialism, systemic racism, and the intergenerational impacts of trauma, requiring its own distinctive suite of responses, \u2018uncoupled\u2019 from the dominant feminist narrative of gender inequality, coercive control and patriarchy. We conclude that achieving meaningful reductions in family violence hinges on a decolonising process that shifts power from settler to Aboriginal structures. Aboriginal peoples are increasingly advocating for strengths-based and community-led solutions that are culturally safe, involve Aboriginal justice models, and recognises the salience of Aboriginal Law and Culture. This paper is based on qualitative research in six locations in northern Australia where traditional patterns of Aboriginal Law and Culture are robust. Employing a decolonising methodology, we explore the views of Elders in these communities regarding the existing role of Law and Culture, their criticisms of settler law, and their ambitions for a greater degree of partnership between mainstream and Aboriginal law. The paper advances a number of ideas, based on these discussions, that might facilitate a paradigm shift in theory and practice regarding intervention in family violence. <\/jats:p>","DOI":"10.1177\/09646639211046134","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T11:27:01Z","timestamp":1635506821000},"page":"535-558","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Law, Culture and Decolonisation: The Perspectives of Aboriginal Elders on Family Violence in Australia"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0432-5756","authenticated-orcid":false,"given":"Harry","family":"Blagg","sequence":"first","affiliation":[{"name":"University of Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Hovane","sequence":"additional","affiliation":[{"name":"University of Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6225-8547","authenticated-orcid":false,"given":"Tamara","family":"Tulich","sequence":"additional","affiliation":[{"name":"University of Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donella","family":"Raye","sequence":"additional","affiliation":[{"name":"University of Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzie","family":"May","sequence":"additional","affiliation":[{"name":"University of Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Worrigal","sequence":"additional","affiliation":[{"name":"University of Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"bibr1-09646639211046134","volume-title":"Ending Family Violence and Abuse in Aboriginal and Torres Strait Islander Communities \u2013 Key Issues. 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Canberra: ALRC."},{"key":"bibr14-09646639211046134","unstructured":"Australian Law Reform Commission, & New South Wales Law Reform Commission (2010) Family Violence: A National Legal Response. Canberra: ALRC."},{"key":"bibr15-09646639211046134","volume-title":"Reshaping responses to domestic violence: Final report","author":"Bagshaw D","year":"2009"},{"key":"bibr16-09646639211046134","doi-asserted-by":"publisher","DOI":"10.1177\/0004865813503351"},{"key":"bibr17-09646639211046134","first-page":"178","volume-title":"Restorative Justice and Family Violence","author":"Behrendt L","year":"2002"},{"key":"bibr18-09646639211046134","volume-title":"Indigenous Legal Relations in Australia","author":"Behrendt L","year":"2009"},{"key":"bibr19-09646639211046134","doi-asserted-by":"publisher","DOI":"10.5204\/ijcis.v3i1.57"},{"key":"bibr21-09646639211046134","first-page":"191","volume-title":"Restorative Justice and Family Violence","author":"Blagg H","year":"2002"},{"key":"bibr100-09646639211046134","unstructured":"Blagg H (2008) Crisis intervention in Aboriginal family violence: Summary Report. 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(2017). Towards an Aboriginal and Torres Strait Islander violence prevention framework for men and boys. Sydney: The Healing Foundation and White Ribbon Australia. https:\/\/www.whiteribbon.org.au\/awcontent\/whiteribbon\/documents\/White-Ribbon-Australia-Towards-an-Aboriginal-and-Torres-Strait-Islander-violence-prevention-framework.pdf."},{"key":"bibr43-09646639211046134","first-page":"13","volume":"1","author":"Hovane V","year":"2015","journal-title":"ANROWS Footprints"},{"key":"bibr44-09646639211046134","unstructured":"Hovane V, Cox D (2011) Closing the gap on family violence: Driving prevention and intervention through health policy. Australian Domestic Violence Clearinghouse, Issues Paper 21. Sydney: University of New South Wales."},{"key":"bibr45-09646639211046134","first-page":"206","volume-title":"Restorative Justice and Family Violence","author":"Kelly L","year":"2002"},{"key":"bibr46-09646639211046134","doi-asserted-by":"publisher","DOI":"10.1080\/15313204.2018.1474827"},{"key":"bibr47-09646639211046134","unstructured":"Kimberley Land Council and Waringarri Resource Centre (1991) Report of the conference on resource development and Kimberley Aboriginal control (Crocodile Hole Report). Derby: Kimberley Law Council."},{"key":"bibr48-09646639211046134","unstructured":"Langton M. (2018) For her, we must Griffith Review 60: First Things First Retrieved from: https:\/\/griffithreview.com\/articles\/for-her-we-must-no-excuses-naidoc-marcia-langton\/"},{"key":"bibr49-09646639211046134","unstructured":"Law Reform Commission of Western Australia (2005) Aboriginal customary laws: Discussion paper. 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Afterall: A Journal of Art, Context and Enquiry 43 (Spring\/Summer).","DOI":"10.1086\/692552"},{"key":"bibr58-09646639211046134","volume-title":"In Search of Justice in Domestic and Family Violence","author":"Nancarrow H","year":"2003"},{"key":"bibr59-09646639211046134","doi-asserted-by":"publisher","DOI":"10.1177\/1362480606059986"},{"key":"bibr60-09646639211046134","first-page":"123","volume-title":"Restorative Justice and Violence Against Women","author":"Nancarrow H","year":"2010"},{"key":"bibr61-09646639211046134","unstructured":"Nancarrow H (2016) Legal Responses to Intimate Partner Violence: Gendered Aspirations and Racialised Realities. Doctoral dissertation. Retrieved from https:\/\/www120.secure.griffith.edu.au\/rch\/file\/f834fc81-0a03-46eb-b8f0-0117496974db\/1\/Nancarrow_2016_01Thesis.pdf"},{"key":"bibr62-09646639211046134","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-27500-6"},{"key":"bibr63-09646639211046134","volume-title":"Position Statement: What\u2019s Needed to Improve Child Abuse\/Family Violence in A Social and Emotional Wellbeing Framework in Aboriginal Communities","author":"National Aboriginal Community Controlled Health Organisation","year":"2006"},{"key":"bibr64-09646639211046134","unstructured":"Northern Territory Law Reform Committee (2003) Report of the committee of inquiry into Aboriginal customary Law. Darwin: NTLRC."},{"key":"bibr65-09646639211046134","unstructured":"Northern Territory Law Reform Committee (2020). Two Justice Systems Working Together, Report on the Recognition of Local Aboriginal Laws in Sentencing and Bail. Darwin: NTLRC."},{"key":"bibr66-09646639211046134","doi-asserted-by":"publisher","DOI":"10.1891\/9780826179913"},{"key":"bibr67-09646639211046134","volume-title":"Decolonizing Methodologies: Research and Indigenous Peoples","author":"Smith LT","year":"1999"},{"key":"bibr68-09646639211046134","unstructured":"SNAICC - National Voice for our Children, National Family Violence Prevention Legal Services Forum and National Aboriginal and Torres Strait Islander Legal Services (2017) Strong families, safe kids: Family violence response and prevention for Aboriginal and Torres Strait Islander children and families. September 2017."},{"key":"bibr69-09646639211046134","unstructured":"State of Victoria. (2016). Royal Commission into Family Violence: Report and recommendations, Parl Paper No 132 (2014\u201316)."},{"key":"bibr70-09646639211046134","volume-title":"Basics of Qualitative Research: Techniques and Procedures for Developing Grounded Theory","author":"Strauss A","year":"1998"},{"key":"bibr72-09646639211046134","first-page":"173","volume-title":"Law Reform Commission of Western Australia Aboriginal Customary Laws Project 94: Background Papers","author":"Toohey JL","year":"2006"},{"key":"bibr73-09646639211046134","unstructured":"United Nations General Assembly (1993) Declaration on the Elimination of Violence against Women. Retrieved from https:\/\/www.ohchr.org\/Documents\/ProfessionalInterest\/eliminationvaw.pdf"},{"key":"bibr75-09646639211046134","unstructured":"UWA School of Indigenous Studies (2017) A Guide to Appropriate Language and Terminology. Retrieved March 15, 2019 from http:\/\/www.sis.uwa.edu.au\/students\/essay-writing-advice."},{"key":"bibr76-09646639211046134","volume-title":"Gender Equality and Violence Against Women: What\u2019s the Connection? (ACSSA Research Summary)","author":"Wall L","year":"2014"},{"key":"bibr77-09646639211046134","doi-asserted-by":"publisher","DOI":"10.1080\/13200968.2007.10854380"},{"key":"bibr78-09646639211046134","doi-asserted-by":"publisher","DOI":"10.1177\/117718011401000506"},{"key":"bibr79-09646639211046134","volume-title":"Aboriginal Peoples, Colonialism and International law\u202f: Raw law","author":"Watson I","year":"2015"},{"key":"bibr80-09646639211046134","doi-asserted-by":"crossref","unstructured":"Watson I (2018) Aboriginal Laws and Colonial Foundation. Griffith Law Review 26(4): 469\u2013479.","DOI":"10.1080\/10383441.2018.1539893"},{"key":"bibr81-09646639211046134","volume-title":"Kimberley Family Violence Regional Plan 2015-2020s","author":"Western Australia Department for Child Protection and Family Support","year":"2015"},{"key":"bibr82-09646639211046134","volume-title":"\u2018Little Children are Sacred\u2019 Report of the Northern Territory Board of Inquiry Into the Protection of Aboriginal Children From Sexual Abuse","author":"Wild R","year":"2007"},{"key":"bibr83-09646639211046134","doi-asserted-by":"publisher","DOI":"10.1080\/14623520601056240"},{"issue":"1","key":"bibr84-09646639211046134","first-page":"17","volume":"6","author":"Wright H","year":"2004","journal-title":"Indigenous Law Bulletin"},{"key":"bibr85-09646639211046134","doi-asserted-by":"publisher","DOI":"10.1177\/0886260504263868"}],"container-title":["Social & Legal Studies"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09646639211046134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09646639211046134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09646639211046134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T23:00:28Z","timestamp":1740870028000},"score":7.668609,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09646639211046134"}},"issued":{"date-parts":[[2021,10,29]]},"references-count":86,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1177\/09646639211046134"],"URL":"https:\/\/doi.org\/10.1177\/09646639211046134","ISSN":["0964-6639","1461-7390"],"issn-type":[{"value":"0964-6639","type":"print"},{"value":"1461-7390","type":"electronic"}],"published":{"date-parts":[[2021,10,29]]}},{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T12:44:10Z","timestamp":1770554650766,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T00:00:00Z","timestamp":1458086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Western Australian State Health Research Advisory Committee"},{"name":"Harold and Sylvia Rowell Clinician Research Fellowship, RPH"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Background<\/jats:title>The aim of this study was to confirm that radio\u2010guided occult lesion localization using low activity iodine 125 (I\u2010125) seeds (ROLLIS<\/jats:styled-content>) could be safely and accurately used for localization and guided excision of impalpable breast lesions in different multidisciplinary settings and to prepare staff for a randomized controlled trial.<\/jats:p><\/jats:sec>Method<\/jats:title>Preoperative image\u2010guided localization of 102 lesions using one or two I\u2010125 seeds with hook\u2010wire back\u2010up was performed in 99 participants at two tertiary hospitals. Preoperative core biopsy in 24 lesions was benign or indeterminate (Group A) and malignant in 78 lesions (Group B). Imaging and histopathology findings and re\u2010excision rates were recorded. Training requirements for new staff and seed handling protocols were refined.<\/jats:p><\/jats:sec>Results<\/jats:title>All seeds and lesions were successfully removed. In five of 23 Group A participants, malignancy on final pathology required definitive surgery for positive margins. The re\u2010excision rate in Group B was 17%. Overall re\u2010excision rate was 18%. Thirty\u2010seven clinical staff members were trained. Sentinel node localization was successful in all 76 cases. Seeds of low activity were successfully used.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The ROLLIS<\/jats:styled-content> technique using a lower dose (\u223c2 MBq<\/jats:styled-content>) seed is safe, effective and can easily be adopted in a large multi\u2010disciplinary setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.13460","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T02:08:55Z","timestamp":1458353335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Iodine\u2010125 seeds to guide removal of impalpable breast lesions: radio\u2010guided occult lesion localization \u2013 a pilot study"],"prefix":"10.1111","volume":"87","author":[{"given":"Anita G.","family":"Bourke","sequence":"first","affiliation":[{"name":"Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"School of Surgery University of Western Australia Perth Western Australia 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Journal of Surgery"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.13460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.13460","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.13460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:49:48Z","timestamp":1695502188000},"score":7.6685967,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.13460"}},"issued":{"date-parts":[[2016,3,16]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/ans.13460"],"URL":"https:\/\/doi.org\/10.1111\/ans.13460","archive":["Portico"],"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"published":{"date-parts":[[2016,3,16]]},"assertion":[{"value":"2015-12-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication 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prospective study of patients on the waiting-list for a THA\/TKA in the South Australian public healthcare system and compared the findings to healthy participants and patients newly referred from their general practitioners. Participants with a history of joint replacements, pacemakers and cancers were excluded from this study. Outcomes of this study included (i) sarcopenia screening (SARC-F \u22654); (ii) sarcopenia, defined as low muscle strength (hand grip strength M<27kg; F<16kg), low muscle quality (skeletal muscle index M<27%, F<22.1%) and low physical performance (short physical performance battery \u22648). Additional outcomes include descriptions of the recruitment feasibility, randomisation and suitability of the assessment tools.<\/jats:p>29 healthy controls were recruited; following screening, 83% (24\/29) met the inclusion criteria and 75% (18\/24) were assessed. 42 newly referred patients were recruited; following screening, 67% (30\/45) met the inclusion criteria and 63% (19\/30) were assessed. 68 waiting list patients were recruited; following recruitment, 24% (16\/68) met the inclusion criteria and 75% (12\/16) were assessed. Preliminary data shows increasing waiting time is associated with higher SARC-F scores, lower hand grip strength and lower muscle quality.<\/jats:p>As a pilot study, preliminary data demonstrate that: (1) study subjects\u2019 willingness to participate will enable a larger study to be conducted to establish the prevalence of sarcopenia and the diagnostic cut-off points for this patient group. (2) SARC-F is a suitable tool to screen for sarcopenia. (3) There is a positive correlation between waiting time for a THA\/TKA and sarcopenia.<\/jats:p>","DOI":"10.1302\/1358-992x.2023.2.101","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T12:33:34Z","timestamp":1676032414000},"page":"101-101","update-policy":"http:\/\/dx.doi.org\/10.1302\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["THE LONG ARTHROPLASTY WAITING TIMES EFFECT ON SARCOPENIA (THE LATE STUDY) IN THE SOUTH AUSTRALIA PUBLIC HEALTHCARE SYSTEM: A PILOT STUDY"],"prefix":"10.1302","volume":"105-B","author":[{"given":"W.P.J.","family":"Tan","sequence":"first","affiliation":[{"name":"Royal Adelaide Hospital, South Australia, Australia"},{"name":"The Queen Elizabeth Hospital, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Yu","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, South Australia, Australia"},{"name":"The Queen Elizabeth Hospital, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Gill","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, South Australia, Australia"},{"name":"The Queen Elizabeth Hospital, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, South Australia, Australia"},{"name":"The Queen Elizabeth Hospital, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Umapathysivam","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, South Australia, Australia"},{"name":"The Queen Elizabeth Hospital, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Smitham","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, South Australia, Australia"},{"name":"The Queen Elizabeth Hospital, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"42","container-title":["Orthopaedic Proceedings"],"language":"en","link":[{"URL":"https:\/\/boneandjoint.org.uk\/doi\/10.1302\/1358-992X.2023.2.101\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/boneandjoint.org.uk\/doi\/10.1302\/1358-992X.2023.2.101\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/boneandjoint.org.uk\/doi\/pdf\/10.1302\/1358-992X.2023.2.101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T12:33:34Z","timestamp":1676032414000},"score":7.6683316,"resource":{"primary":{"URL":"https:\/\/boneandjoint.org.uk\/doi\/10.1302\/1358-992X.2023.2.101"}},"issued":{"date-parts":[[2023,2]]},"references-count":0,"journal-issue":{"issue":"SUPP_2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1302\/1358-992X.2023.2.101"],"URL":"https:\/\/doi.org\/10.1302\/1358-992x.2023.2.101","ISSN":["1358-992X","2049-4416"],"issn-type":[{"value":"1358-992X","type":"print"},{"value":"2049-4416","type":"electronic"}],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"2023-2-","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T08:02:26Z","timestamp":1781164946955,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2023,6]]},"abstract":"Abstract<\/jats:title>Reducing preventable readmissions is important to help manage current strains on healthcare systems. The metric of 30\u2010day readmissions is commonly cited in discussions regarding this topic. While such thresholds have contemporary funding implications, the rationale for individual cut\u2010off points is partially historical in nature. Through the examination of the basis for the analysis of 30\u2010day readmissions, greater insight into the possible benefits and limitations of such a metric may be obtained.<\/jats:p>","DOI":"10.1111\/imj.16115","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T11:16:26Z","timestamp":1686136586000},"page":"1070-1075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Why do we evaluate 30\u2010day readmissions in general medicine? A historical perspective and contemporary data"],"prefix":"10.1111","volume":"53","author":[{"given":"Jonathan","family":"James","sequence":"first","affiliation":[{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8310-0853","authenticated-orcid":false,"given":"Sheryn","family":"Tan","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-3489","authenticated-orcid":false,"given":"Brandon","family":"Stretton","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua 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The Androgen Receptor (AR) is a key driver of prostate cancer and anti-androgen therapy is a mainstay of current prostate cancer treatment regimes. We have observed that concomitant TRPV6 and AR inhibition is synergistic in prostate cancer cells resulting in a highly anti-proliferative effect. Our preclinical candidate QED-203 inhibits TRPV6-mediated calcium influx with low nM potency and inhibits AR activity. QED-203 maintains effectiveness in prostate cancer cell lines that are resistant to next generation AR inhibitors (e.g. enzalutamide) with multiple resistance mechanisms including the ARV7 variant. QED-203 has high oral bioavailability with a pharmacokinetic profile amenable to once-a-day dosing. QED-203 is well tolerated in rodents with excellent in vivo efficacy in castrated mouse models of prostate cancers, including a PDX model with pronounced resistance to first and second-generation AR inhibitors (HID-28). TRPV6 target engagement has been demonstrated for QED-203 in rodents through changes in urine calcium levels, and via gene expression changes consistent with TRPV6 inhibition in xenograft tumours. QED-203 thus targets a novel dual axis pathway (AR\/TRPV6) to supress prostate cancer growth. QED-203 may offer a new opportunity to treat prostate cancer patients who have developed resistance to next generation AR therapies, where there is a clear clinical need for new therapeutic approaches.<\/jats:p>\n <\/jats:sec>\n \n Citation Format:<\/jats:title>\n Gregory R. Monteith, Kimberley Beaumont, Rebecca Pouwer, Rebecca Farrow, Matthew McLachlan, Mei Yeh, Akanksha Upadhyaya, Aaron Gregson, Therese Johnson, Raphael Rahmani, Claire Levrier, Hasanthi Wijesekera, Malika Kumarasiri, Grant Stuchbury, Terrie-Anne Cock, Andrew Harvey, Brian Dymock. Evaluation of a first-in-class dual TRPV6\/AR inhibitor for the treatment of prostate cancer [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; 2025 Oct 22-26; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2025;24(10 Suppl):Abstract nr B017.<\/jats:p>\n <\/jats:sec>","DOI":"10.1158\/1535-7163.targ-25-b017","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:05:51Z","timestamp":1761152751000},"page":"B017-B017","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract B017: Evaluation of a first-in-class dual TRPV6\/AR inhibitor for the treatment of prostate cancer"],"prefix":"10.1158","volume":"24","author":[{"given":"Gregory R.","family":"Monteith","sequence":"first","affiliation":[{"name":"1University of Queensland, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberley","family":"Beaumont","sequence":"additional","affiliation":[{"name":"2UniQuest, Brisbane, 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Medicine Journal"],"published-print":{"date-parts":[[2023,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Antimicrobial resistance and therapy\u2010related adverse effects make Mycobacterium abscessus<\/jats:italic> treatment challenging. Omadacycline is a novel, bioavailable aminomethylcycline with favourable in vitro<\/jats:italic> activity against M. abscessus<\/jats:italic>.<\/jats:p><\/jats:sec>Aims<\/jats:title>To describe a case report and review the published literature describing outcomes for M. abscessus<\/jats:italic> infections treated with omadacycline.<\/jats:p><\/jats:sec>Methods<\/jats:title>Systematic literature review.<\/jats:p><\/jats:sec>Results<\/jats:title>We identified three articles that, in addition to our case report, describe 18 patients. Pulmonary infections were most frequent. Minimum inhibitory concentrations were reported for two isolates (0.25 and 0.5 mg\/L). Despite half the patients starting omadacycline because of failure of prior therapy, 15 (83%) had a favourable outcome, defined as \u2018cure\u2019, \u2018improvement\u2019 or \u2018clinical success\u2019 as determined by the primary study authors. One patient (6%) discontinued omadacycline because of gastrointestinal intolerance.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Although the limited observational data and in vitro<\/jats:italic> susceptibility results are encouraging, randomised control trials are required to determine the role of omadacycline as part of combination therapy for this most difficult\u2010to\u2010treat pathogen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.16071","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T15:29:25Z","timestamp":1678807765000},"page":"2257-2263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Omadacycline therapy for Mycobacterium abscessus<\/i> species infections"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7733-7072","authenticated-orcid":false,"given":"Paul R.","family":"Ingram","sequence":"first","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"},{"name":"PathWest Laboratory Medicine Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethwyn","family":"Allen","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronan J.","family":"Murray","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"},{"name":"Sir Charles Gairdner Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terillee J.","family":"Keehner","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Whitmore","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"},{"name":"Anita Clayton Centre Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,25]]},"reference":[{"key":"e_1_2_7_2_1","article-title":"Utilizing the promise of omadacycline in a resistant, non\u2010tubercular mycobacterial pulmonary infection","volume":"11","author":"Minhas R","year":"2019","journal-title":"Cureus"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01947-20"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa415"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku062"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00067"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01704-21"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2017-000242"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01132-13"},{"volume-title":"Performance Standards for Susceptibility Testing of Mycobacteria, Nocardia spp., and Other Aerobic Actinomycetes","year":"2018","author":"CLSI","key":"e_1_2_7_11_1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.5.1271"},{"key":"e_1_2_7_13_1","first-page":"1225","article-title":"Evaluation of the use of omadacycline in adults with nontuberculous mycobacterium infections","volume":"4","author":"Giang GFP","year":"2021","journal-title":"J Am Coll Clin Pharm"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2021.08.002"},{"key":"e_1_2_7_15_1","article-title":"Mycobacterium abscessus infection in left ventricular assist device (LVAD): a case series","volume":"13","author":"Hernandez JM","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_7_16_1","unstructured":"GuzmanJ Bolender E SabetS MartinK.Multi\u2010Drug ResistantMycobacterium abscessusOsteomyelitis Following an ATV Accident; 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Following the PRISMA guidelines and the PICO framework, this review was conducted between January and July 2021. Included articles needed to evaluate communication pathway interventions for continuity of care between the emergency department and mental health community services which support service users with mental health and\/or suicidal crisis. The seven included studies identified three support coordination interventions, two motivational interviewing interventions, an electronic record enhanced strategy and results from a phone follow\u2010up study. This review demonstrates that support coordination, motivational interviewing, education, or an enhanced electronic record strategy can improve continuity of care, and in some cases, reduce the need for people to re\u2010present to ED when they are experiencing mental health concerns or suicidal crisis. Results of this review reveal that a multipronged approach of communication pathways for continuity of care would enable more effective connections with mental health community supports and enable better outcomes for people requiring services.<\/jats:p>","DOI":"10.1111\/inm.13024","type":"journal-article","created":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T16:24:21Z","timestamp":1653236661000},"page":"1282-1299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Communication pathways from the emergency department to community mental health services: A systematic review"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8475-769X","authenticated-orcid":false,"given":"Heather","family":"McIntyre","sequence":"first","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6084-3606","authenticated-orcid":false,"given":"Verity","family":"Reeves","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3610-1482","authenticated-orcid":false,"given":"Mark","family":"Loughhead","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2109-6091","authenticated-orcid":false,"given":"Laura","family":"Hayes","sequence":"additional","affiliation":[{"name":"MIND Australia Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7289-3165","authenticated-orcid":false,"given":"Nicholas","family":"Procter","sequence":"additional","affiliation":[{"name":"MIND Australia Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hsc.13558"},{"key":"e_1_2_13_3_1","volume-title":"Patient Centred Care: Improving Quality and Safety Through Partnerships with Patients and Consumers","author":"Australian Commission on Safety and Quality in Health Care","year":"2011"},{"key":"e_1_2_13_4_1","volume-title":"National Safety and Quality Health Service Standards","author":"Australian Commission on Safety and Quality in Health Care","year":"2017"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/01612840.2012.687803"},{"key":"e_1_2_13_6_1","volume-title":"The Long Wait: An Analysis of Mental Health Presentations to Australian Emergency Departments","author":"Australasian College for Emergency Medicine","year":"2018"},{"key":"e_1_2_13_7_1","volume-title":"National Standards for Mental Health Services","author":"Australian Government","year":"2010"},{"key":"e_1_2_13_8_1","unstructured":"Australian Institute of Health and Welfare(2018).Emergency department care 2017\u201318: Australian hospital statistics Health services series no. 89. 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staff"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3880-3840","authenticated-orcid":false,"given":"Joshua G.","family":"Kovoor","sequence":"first","affiliation":[{"name":"Flinders Medical Centre Adelaide South Australia Australia"},{"name":"Queen Elizabeth Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Health and Information Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-0378","authenticated-orcid":false,"given":"Aashray K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Health and Information Adelaide South Australia Australia"},{"name":"Gold Coast University Hospital Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Bacchi","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Health and Information Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-3489","authenticated-orcid":false,"given":"Brandon","family":"Stretton","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Health and Information Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert T.","family":"Padbury","sequence":"additional","affiliation":[{"name":"Flinders Medical Centre Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"e_1_2_2_2_1","unstructured":"McElhattonJ DrewC.Hurry\u2010Up Syndrome. Edition. [Cited 2 April 2023.] Available from URL:https:\/\/asrs.arc.nasa.gov\/publications\/directline\/dl5_hurry.htm"},{"key":"e_1_2_2_3_1","unstructured":"McElhattonJ DrewC.\u201cHurry up\u201d Syndrome. Air Line Pilot;1994."},{"key":"e_1_2_2_4_1","unstructured":"McElhattonJ DrewC.\u2018Hurry\u2010Up\u2019 Syndrome Identified as a Causal Factor In Aviation Safety Incidents. Edition[Cited 2 April 2023.] Available from:https:\/\/flightsafety.org\/hf\/hf_sep-oct93.pdf"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-812995-1.00004-X"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja15.01177"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5425"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/qshc.2004.009936"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.08.015"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7237.768"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60160-X"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-002700"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.10.007"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa022151"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-061410-121352"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.5703"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2019.1738"},{"key":"e_1_2_2_18_1","first-page":"39","article-title":"The economics of health care quality and medical errors","volume":"39","author":"Andel C","year":"2012","journal-title":"J. Health Care Finance"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.8.1001"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181bfdab3"}],"container-title":["ANZ Journal of Surgery"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.18593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T11:35:31Z","timestamp":1691753731000},"score":7.6655693,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.18593"}},"issued":{"date-parts":[[2023,7]]},"references-count":19,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/ans.18593"],"URL":"https:\/\/doi.org\/10.1111\/ans.18593","archive":["Portico"],"ISSN":["1445-1433","1445-2197"],"issn-type":[{"type":"print","value":"1445-1433"},{"type":"electronic","value":"1445-2197"}],"published":{"date-parts":[[2023,7]]}},{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:26:38Z","timestamp":1787246798593,"version":"build-2736575974"},"reference-count":0,"publisher":"Society of Exploration Geophysicists","content-domain":{"domain":[],"crossmark-restriction":false},"abstract":"Geoscience Australia conducted a marine survey in the Caswell Sub-basin of the Browse Basin, offshore Western Australia, in late 2014 to investigate containment questions relating to the potential long-term geological storage of CO2. The survey aimed to identify and characterise indicators of natural hydrocarbon or fluid seepage that may suggest the presence of deep plumbing systems which could compromise seal integrity. Prior to the survey, 2D and 3D seismic data were used to map fault networks connecting the Aptian regional seal to the sea floor and any associated amplitude anomalies. This mapping informed survey site selection aimed at testing seal integrity over Maastrichtian, Campanian, Valanginian and Barremian submarine fans in the Caswell Sub-basin, and up-dip migration and leakage of hydrocarbons, via channels and basin margin faults, such as the Heywood Fault, into shallow marine sands on the eastern shelf margin. Vessel and Autonomous Underwater Vehicle (AUV) multibeam bathymetry and sub-bottom profiler systems confirmed the presence of recently active faults in the area, some with significant seafloor surface expression (up to 40m offset). A subset of these faults was visually inspected with a Remotely Operated Vehicle (ROV) which also confirmed the presence of diverse biological communities. Indications of shallow gas were observed on sub-bottom profiles, including amplitude anomalies, cross-cutting reflectors and zones of signal starvation. Water column observations including sidescan sonar, single-beam and multibeam echosounders, underwater video and photography did not conclusively identify hydrocarbon or other fluid seepage. Strong currents encountered during parts of the survey may have interfered with the direct detection of seeps in the water column. However, headspace gas and high-molecular weight hydrocarbon analysis from shallow cores also provided no evidence for migrated thermogenic gas or oil. While no active signs of seepage were observed, the geochemical and biological sampling undertaken will aid in baseline environmental investigations for this region.<\/jats:p>","DOI":"10.1190\/ice2015-2210674","type":"proceedings-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T14:10:38Z","timestamp":1458223838000},"page":"202-202","source":"Crossref","is-referenced-by-count":0,"title":["Browse Basin 2014 Marine Survey\u2014Investigating Containment for Potential Late Cretaceous CO2 Storage Plays"],"prefix":"10.1190","volume":"1","author":[{"given":"Chris","family":"Nicholson*","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowan","family":"Romeyn","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Lech","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve T.","family":"Abbott","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Bernardel","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Carroll","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Caust","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Grosjean","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Hackney","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floyd","family":"Howard","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Melrose","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Nichol","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Radke","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadege","family":"Rollet","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justy","family":"Siwabessy","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Trafford","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"186","published-online":{"date-parts":[[2015,9,16]]},"event":{"name":"International Conference and Exhibition, Melbourne, Australia 13-16 September 2015","location":"Melbourne, Australia","acronym":"icemelbourne2015","start":{"date-parts":[[2015,9,13]]},"end":{"date-parts":[[2015,9,16]]}},"container-title":["Global Meeting Abstracts","International Conference and Exhibition, Melbourne, Australia 13-16 September 2015"],"link":[{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/202\/714208","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/202\/714208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:43:06Z","timestamp":1787244186000},"score":7.6655145,"resource":{"primary":{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/202\/714208"}},"issued":{"date-parts":[[2015,9,16]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1190\/ice2015-2210674","ISSN":["2159-6832"],"issn-type":[{"value":"2159-6832","type":"electronic"}],"published":{"date-parts":[[2015,9,16]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:52Z","timestamp":1753889812600,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Objective: To examine the effects of change in glycaemic control on clinical outcomes in patients with type 2 diabetes.<\/jats:p>\n Research Design and Methods: Data were obtained from 9981 participants of the ADVANCE trial and ADVANCE-ON follow-up. Participants were categorized into 3 groups by glycated haemoglobin (HbA1c) change from baseline to 6 months, &gt;0.25% decrease, &gt;0.25% increase and minimal change (\u00b10.25%). Adjusted Cox and logistic regression analyses examined relationships between HbA1c change and all-cause mortality, macrovascular events, microvascular events and severe hypoglycaemia.<\/jats:p>\n Results: Mean (\u00b1SD) age was 65.8\u00b16.4 years, diabetes duration 7.9\u00b16.4 years and HbA1c 7.5\u00b11.6% at baseline. In the first 6 months, 48%, 22% and 30% of participants had an HbA1c decrease, minimal change or increase respectively. Median (IQR) follow-up was 9.4 (5.1-10.4) years. Compared to those with minimal HbA1c change at 6 months, participants with an HbA1c increase at 6 months had greater risk of risk of all-cause mortality [1.26 (1.11-1.43)], macrovascular events [1.26 (1.10-1.44)] and microvascular disease [1.36 (1.09-1.70) whereas participants with an HbA1c decrease did not have greater risk of all-cause mortality [0.99 (0.87-1.12)], macrovascular events [1.06 (0.93-1.21)] or microvascular disease [0.97 (0.77-1.21)]. Neither HbA1c increase [1.05 (0.83-1.33)] or decrease [1.16 (0.91-1.47)] was associated with greater risk of severe hypoglycaemia. These effects were similar when HbA1c change at 3 months was considered and in subgroup analyses by age, gender, diabetes duration, or baseline HbA1c.<\/jats:p>\n Conclusions: Increased rather than decreased HbA1c at 6 months was associated with increased risks of death and vascular events in type 2 diabetes.<\/jats:p>\n \n Disclosure<\/jats:title>\n N. Nanayakkara: None. T. Ohkuma: None. M. Woodward: Consultant; Self; Amgen Inc., Kirin. J. Chalmers: Research Support; Self; Idorsia. S. Zoungas: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-251-or","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T02:36:40Z","timestamp":1559702200000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["251-OR: Relationship of Short-Term HbA1c Change with Vascular Events, Severe Hypoglycaemia, and Mortality"],"prefix":"10.2337","volume":"68","author":[{"given":"NATALIE","family":"NANAYAKKARA","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Camperdown, Australia, Oxford, United Kingdom, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOSHIAKI","family":"OHKUMA","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Camperdown, Australia, Oxford, United Kingdom, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"ESQ.","given":"MARK","family":"WOODWARD","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Camperdown, Australia, Oxford, United Kingdom, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN","family":"CHALMERS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Camperdown, Australia, Oxford, United Kingdom, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SOPHIA","family":"ZOUNGAS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Camperdown, Australia, Oxford, United Kingdom, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/251-OR\/61428\/251-OR-Relationship-of-Short-Term-HbA1c-Change","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/251-OR\/61428\/251-OR-Relationship-of-Short-Term-HbA1c-Change","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T11:17:55Z","timestamp":1647170275000},"score":7.6653776,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/251-OR\/61428\/251-OR-Relationship-of-Short-Term-HbA1c-Change"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-251-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"251-OR"},{"indexed":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T01:23:29Z","timestamp":1711157009216},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"6_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,3,22]]},"abstract":"Abstract<\/jats:title>\n Background: Approximately 1 in 3 pts with PD1-resistant MM will benefit from IPI+PD1, but the role of adding IPI in this context is unclear. We sought to (a) identify biomarkers and (b) determine mechanisms of response to IPI+PD1 in PD1 resistant pts.<\/jats:p>\n Methods: Pts with PD1-resistant MM subsequently treated with IPI+PD1 were included. We performed multiplex immunofluorescence (mIF), imaging mass cytometry (IMC) and RNA sequencing (RNAseq) on melanoma samples, and cytometry by time of flight (CYTOF) on peripheral blood mononuclear cells (PBMCs), at 3 timepoints (before PD1 [T1], before IPI+PD1 [T2], and after IPI+PD1 [T3]).<\/jats:p>\n Results: 34 pts with PD1-resistant MM (82% innate resistance) who received IPI+PD1 were included: 16 (47%) responders and 18 (53%) non-responders to IPI+PD1. Median age was 66yo (37-86) and 19 (56%) were male. Six pts (18%) were ECOG PS \u22651, 18 (53%) were stage M1C\/D and 11 (32%) had elevated LDH at the start of IPI+PD1.Gene expression analysis (RNAseq) on T1 and T2 tumor samples revealed higher expression of cancer testis antigens (CTA; MAGE-A3 and MAGE-C1; p&lt;0.05) and immune regulatory genes (ILR2; p&lt;0.2), but lower expression of fibrosis regulation genes (FABP3 and MMP7; p &lt; 0.2) in responders vs non-responders. We then examined whether the addition of IPI led to expansion of CTA-specific T cells, and CyTOF analysis of MAGE-A3 tetramers on PBMCs showed a decrease in peripheral MAGE-A3-specific CD8+ T cells with PD1 (T1 to T2; p=0.03); and expansion of this T-cell subset with subsequent IPI+PD1 (T2 to T3) was seen in 7\/12 HLA-A2+ pts. Further analysis on PBMC longitudinal samples showed an increase in regulatory T cells (Tregs) in responders (p=0.04), between T1 and T3, and a decrease in % of TCF7+ CD8+ & CD4+ T cells in non-responders (p&lt;0.05) with the addition of IPI (T2 to T3). On baseline (T1) tumor samples (mIF), IPI+PD1 responders had a higher % of stem cell-like TCF7+ CD8+ T cells (p=0.0004), lower % of well-differentiated Tbet+ CD8+ T cells (p=0.07), and higher % of CD4+ T cells (p=0.006), compared with non-responders; but no difference in Tregs. On longitudinal tumor samples, there was a decrease in the % of stem cell-like TCF7+ CD8+ T cells but an increase in the % of tumor-reactive CD39+ CD103+ CD8+ T cells with PD1 (T1 to T2; p&lt;0.05), mainly seen in responders (p=0.06). There were only 3 T2 to T3 IHC paired samples, precluding further analysis. IMC analysis on longitudinal samples (T1, T2 and T3) is underway to characterize the interaction between Tregs and T effector cells.<\/jats:p>\n Conclusions: We identified potential mechanisms of response to IPI+PD1 in PD1-resistant MM pts. Our data suggests that response to IPI+PD1 requires baseline stem cell-like TCF7+ T cells with the potential to differentiate to an effector phase (CD39+ CD103+ CD8+ T cells), and that IPI facilitated expansion of antigen-specific T cells in a CTA-expression context, that PD1 alone is unable to do.<\/jats:p>\n Citation Format: Ines Pires da Silva, Jordan Conway, Jarem Edwards, Felix Marsh-Wakefield, Camelia Quek, Angela Ferguson, Peter Johnansson, Matteo Carlino, Alexander Menzies, James Wilmott, Umaimainthan Palendira, Richard Scolyer, Georgina Long. Mechanisms of response to anti-PD1 (PD1) combined with Ipilimumab (IPI) in patients (pts) with PD1-resistant metastatic melanoma (MM) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 7531.<\/jats:p>","DOI":"10.1158\/1538-7445.am2024-7531","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T11:38:09Z","timestamp":1711107489000},"page":"7531-7531","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 7531: Mechanisms of response to anti-PD1 (PD1) combined with Ipilimumab (IPI) in patients (pts) with PD1-resistant metastatic melanoma (MM)"],"prefix":"10.1158","volume":"84","author":[{"given":"Ines Pires","family":"da Silva","sequence":"first","affiliation":[{"name":"1Melanoma Institute Australia, Wollstonecraft, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Conway","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Wollstonecraft, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarem","family":"Edwards","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Wollstonecraft, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Marsh-Wakefield","sequence":"additional","affiliation":[{"name":"2The University of Sydney, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camelia","family":"Quek","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Wollstonecraft, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Ferguson","sequence":"additional","affiliation":[{"name":"2The University of Sydney, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Johnansson","sequence":"additional","affiliation":[{"name":"3QIMR Berghofer Medical Research Institute, Brisbane, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Carlino","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Wollstonecraft, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Menzies","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Wollstonecraft, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Wilmott","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Wollstonecraft, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umaimainthan","family":"Palendira","sequence":"additional","affiliation":[{"name":"2The University of Sydney, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Scolyer","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Wollstonecraft, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina","family":"Long","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Wollstonecraft, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/84\/6_Supplement\/7531\/740253\/Abstract-7531-Mechanisms-of-response-to-anti-PD1","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/84\/6_Supplement\/7531\/740253\/Abstract-7531-Mechanisms-of-response-to-anti-PD1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T11:38:19Z","timestamp":1711107499000},"score":7.6653094,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/84\/6_Supplement\/7531\/740253\/Abstract-7531-Mechanisms-of-response-to-anti-PD1"}},"issued":{"date-parts":[[2024,3,22]]},"references-count":0,"journal-issue":{"issue":"6_Supplement","published-print":{"date-parts":[[2024,3,22]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2024-7531","ISSN":["1538-7445"],"issn-type":[{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2024,3,22]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:06Z","timestamp":1753889766204,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Emerging studies suggest that adipose tissue derived exosomes involves in regulating insulin action and glucose homeostasis. In this study, we hypothesised the protein content of adipose tissue derived exosomes (exo-AT) differs in normal glucose tolerant (NGT) and gestational diabetes mellitus (GDM) pregnancies which lead to changes in placental glucose metabolism. Human omental adipose tissue was obtained from GDM (n=60) and BMI-matched NGT (n=48) pregnancies at the time of term Caesarean section. Exosomes were isolated from tissue-conditioned media by differential centrifugation and characterised using nanoparticle tracking analysis and SWATH mass spectrometry. The effect of exosomes on human placental cells was evaluated using a Human Glucose Metabolism RT\u00b2 Profiler PCR Array. The total number of exosomes (number of vesicles\/mg adipose tissue\/24 hour) were significantly higher in GDM compared to NGT. The number of exosomes positively correlated with maternal BMI and fetal weight. We identified 122 proteins upregulated in the exo-AT from GDM compared to NGT. Ingenuity pathway analysis revealed the upregulated proteins are associated with mitochondrial dysfunction and oxidative phosphorylation (OXPHOS). When compared to NGT exo-AT, GDM exo-AT increased ALDOB, PGK2 and GCK in placental cells. The data obtained in this study suggest that exosomes secreted from adipose tissue regulates placental glucose metabolism in GDM. Improving the communication of exo-AT to placental tissues may serve as an effective intervention strategy to prevent the consequences of GDM such as fetal overgrowth.<\/jats:p>\n \n Disclosure<\/jats:title>\n N. Jayabalan: None. V. Ormazabal: None. A. Lai: None. M. Lappas: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-165-lb","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:32Z","timestamp":1529693852000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["Proteomic Profile of Adipose Tissue-Derived Exosomes and Their Potential Role on Placental Glucose Metabolism in Gestational Diabetes Mellitus"],"prefix":"10.2337","volume":"67","author":[{"given":"NANTHINI","family":"JAYABALAN","sequence":"first","affiliation":[{"name":"Herston, Australia, Concepci\u00f3n, Chile, Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VALESKA","family":"ORMAZABAL","sequence":"additional","affiliation":[{"name":"Herston, Australia, Concepci\u00f3n, Chile, Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREW","family":"LAI","sequence":"additional","affiliation":[{"name":"Herston, Australia, Concepci\u00f3n, Chile, Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTHA","family":"LAPPAS","sequence":"additional","affiliation":[{"name":"Herston, Australia, Concepci\u00f3n, Chile, Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARLOS","family":"SALOMON","sequence":"additional","affiliation":[{"name":"Herston, Australia, Concepci\u00f3n, Chile, Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/165-LB\/54309\/Proteomic-Profile-of-Adipose-Tissue-Derived","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/165-LB\/54309\/Proteomic-Profile-of-Adipose-Tissue-Derived","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T10:35:29Z","timestamp":1652697329000},"score":7.665263,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/165-LB\/54309\/Proteomic-Profile-of-Adipose-Tissue-Derived"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-165-lb","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"165-LB"},{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:26Z","timestamp":1787013926504,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T00:00:00Z","timestamp":1351814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British J of Dev Psycho"],"published-print":{"date-parts":[[2013,6]]},"abstract":"\n Empathy is an essential building block for successful interpersonal relationships. Atypical empathic development is implicated in a range of developmental psychopathologies. However, assessment of empathy in children is constrained by a lack of suitable measurement instruments. This article outlines the development of the Kids' Empathic Development Scale (\n KEDS<\/jats:styled-content>\n ) designed to assess some of the core affective, cognitive and behavioural components of empathy concurrently. The\n KEDS<\/jats:styled-content>\n assesses responses to picture scenarios depicting a range of individual and interpersonal situations differing in social complexity. Results from 220 children indicate the\n KEDS<\/jats:styled-content>\n measures three related but distinct aspects of empathy that are also related to existing measures of empathy and cognitive development. Scores on the\n KEDS<\/jats:styled-content>\n show age and some gender\u2010related differences in the expected direction.\n <\/jats:p>","DOI":"10.1111\/bjdp.12002","type":"journal-article","created":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T08:22:23Z","timestamp":1351844543000},"page":"231-256","source":"Crossref","is-referenced-by-count":60,"title":["The Kids' Empathic Development Scale (\n KEDS<\/scp>\n ): A multi\u2010dimensional measure of empathy in primary school\u2010aged children"],"prefix":"10.1111","volume":"31","author":[{"given":"Corinne","family":"Reid","sequence":"first","affiliation":[{"name":"Neurocognitive Development Unit School of Psychology University of Western Australia Crawley Western Australia Australia"},{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"Murdoch University Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Davis","sequence":"additional","affiliation":[{"name":"Murdoch University Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Horlin","sequence":"additional","affiliation":[{"name":"Neurocognitive Development Unit School of Psychology University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Anderson","sequence":"additional","affiliation":[{"name":"Neurocognitive Development Unit School of Psychology University of Western Australia Crawley Western Australia Australia"},{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Baughman","sequence":"additional","affiliation":[{"name":"Neurocognitive Development Unit School of Psychology University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Campbell","sequence":"additional","affiliation":[{"name":"Neurocognitive Development Unit School of Psychology University of Western Australia Crawley Western Australia Australia"},{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"Centre for Neonatal Research and Education University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0160\u20102896(01)00073\u20103"},{"key":"e_1_2_6_3_1","unstructured":"Andrich D. 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Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534711017137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534711017137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2011.02.1465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T02:50:45Z","timestamp":1651200645000},"score":7.6632843,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2011.02.1465"}},"issued":{"date-parts":[[2011,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1016\/j.juro.2011.02.1465"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2011.02.1465","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2011,4]]}},{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T05:41:34Z","timestamp":1782625294809,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2020,8]]},"abstract":"Endometriosis is a common gynecologic condition affecting as many as 1 per 10 women. Transvaginal ultrasound (TVUS) has become a frontline tool in the diagnosis of deep infiltrating endometriosis (DIE) before surgery. The primary aim of this review was to determine the accuracy of TVUS for DIE. The secondary aim was to determine accuracy specifically when a sonographer performed the TVUS examination. A systematic review was performed, searching literature by following a population, intervention, comparator, and outcome outline. MEDLINE, Embase, Emcare, and Google Scholar were searched in July 2018 and in November 2019. Including \u201csonographer\u201d in the search terms yielded no results, so our terms were expanded. Two hundred and four articles were returned from the searches, and 35 were ultimately included in the final review. Analysis of the returned articles revealed the TVUS is a valuable diagnostic tool for DIE before surgery. Sensitivities ranged from 78.5% to 85.3%, specificities from 46.1% to 92.5%, and accuracies from 75.7% to 97%. Most authors reported site\u2010specific sensitivities and specificities, which varied greatly between locations. Site\u2010specific sensitivities ranged from 10% to 88.9% (uterosacral ligaments), 20% to 100% (bladder), 33.3% to 98.1% (rectosigmoid colon), and 31% to 98.7% (pouch of Douglas). Site\u2010specific specificities ranged from 75% to 99.6% (uterosacral ligaments), 96.4% to 100% (bladder), 86% to 100% (rectosigmoid colon), and 90% to 100% (pouch of Douglas). Transvaginal ultrasound is an accurate tool in the diagnosis of DIE; however, limited data exist as to whether this technique is accurate when performed by sonographers. More evidence surrounding the reliability between operators is also needed.<\/jats:p>","DOI":"10.1002\/jum.15246","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T11:58:21Z","timestamp":1582286301000},"page":"1477-1490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Current Status of Transvaginal Ultrasound Accuracy in the Diagnosis of Deep Infiltrating Endometriosis Before Surgery"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7094-3950","authenticated-orcid":false,"given":"Alison","family":"Deslandes","sequence":"first","affiliation":[{"name":"Specialist Imaging Partners Adelaide South Australia Australia"},{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayana","family":"Parange","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie T.","family":"Childs","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Osborne","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Bezak","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,21]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Australia Government Department of Health. National action plan for endometriosis 2018. Commonwealth of Australia website.https:\/\/www1.health.gov.au\/internet\/main\/publishing.nsf\/Content\/58AD1EF08402AC9FCA2582D5001A271E\/$File\/National%20Action%20Plan%20for%20Endometriosis.pdf. 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of Ultrasound in Medicine"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjum.15246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.15246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jum.15246","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.15246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T16:37:06Z","timestamp":1693931826000},"score":7.663254,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.15246"}},"subtitle":["A Systematic Review of the Literature"],"issued":{"date-parts":[[2020,2,21]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/jum.15246"],"URL":"https:\/\/doi.org\/10.1002\/jum.15246","archive":["Portico"],"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"published":{"date-parts":[[2020,2,21]]},"assertion":[{"value":"2019-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:41:49Z","timestamp":1651203709769},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.juro.2013.02.1611","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T20:59:20Z","timestamp":1364417960000},"source":"Crossref","is-referenced-by-count":0,"title":["231 SURVIVAL ANALYSIS OF A WHOLE OF POPULATION STUDY FOR RADICAL PROSTATECTOMY IN THE PSA ERA"],"prefix":"10.1097","volume":"189","author":[{"given":"Anthony","family":"Ta","sequence":"first","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Severi","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Muller","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Kelsall","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Millar","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney","family":"Syme","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Giles","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Bolton","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534713018879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534713018879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2013.02.1611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:14:52Z","timestamp":1651202092000},"score":7.6630993,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2013.02.1611"}},"issued":{"date-parts":[[2013,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1016\/j.juro.2013.02.1611"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2013.02.1611","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2013,4]]}},{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:07:57Z","timestamp":1780704477700,"version":"3.54.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2026,6,5]]},"abstract":"Introduction and Objective: Insulin-resistant late Gestational Diabetes Mellitus (IR-lGDM) is associated with worse pregnancy outcomes. We compared pregnancy outcomes and treatment effect between women with IR-early GDM (IR-eGDM), non-IR-eGDM and normal glucose tolerance (NGT).<\/jats:p>\n Methods: Pregnant women with GDM-risk factors enrolled in a multicenter RCT performed a 75g early OGTT (eOGTT) &lt;20 wks, with fasting serum insulin, and 24-28 wk OGTT if no GDM on eOGTT (IADPSG criteria). IR-eGDM was defined by Homeostatic Model Assessment (HOMA)-IR &gt;75th percentile from women with NGT, all other eGDM were classified as non-IR-eGDM. Each eGDM subtype was compared to NGT for outcomes and early treatment effect using multiple logistic regression, calculated with adjusted odds ratios (aOR(95% CI)).<\/jats:p>\n Results: Among 488 women with eGDM, median(IQR) HOMA-IR was 2.52(1.65-3.76): 322 (66%) had IR-eGDM using NGT (N=403) HOMA-IR 75th centile threshold of 1.998. For IR-eGDM vs non-IR-eGDM, pre-pregnancy BMI, OGTT fasting glucose and European ethnicity respectively were higher, while gestational weight gain was lower (all p\u22640.001). Relative to women with NGT, early treated IR-eGDM (N=164) was associated with higher odds of hyperbilirubinemia requiring phototherapy (2.65(1.40-5.03)) and NICU admission (1.77(1.07-2.91)). Delayed treatment IR-eGDM (N=158) was also associated with higher odds of hyperbilirubinemia requiring phototherapy and NICU admission, as well as the neonatal adverse outcome composite (1.93(1.19-3.22)) and respiratory distress (2.30(1.25-4.21)). Non-IR-eGDM had similar outcomes to NGT, irrespective of treatment timing.<\/jats:p>\n Conclusion: Women with IR-eGDM have a higher risk of neonatal complications, several of which are attenuated with early treatment. Those with non-IR-eGDM have similar outcomes to women with NGT.<\/jats:p>\n \n Disclosure<\/jats:title>\n A. Sweeting: None. M. Hivert: None. J. Immanuel: None. A.A. Hardikar: None. N. Pham: None. W.M. Hague: None. M.J. Peek: None. V.W. Wong: None. E. Gianatti: None. A. Kautzky-Willer: None. J. Harreiter: None. H.E. Backman: None. V. Mohan: None. C. Nolan: None. D. Simmons: Speaker's Bureau; Ended; Novo Nordisk. Other - Educational grant; Ended; Abbott Diabetes. Research Support; Current; Novo Nordisk. Consultant; Ended; Dexcom, Inc.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n NHMRC (grants 1104231 and 2009326); Region \u00d6rebro Research Committee DnrOLL-970566, OLL-942177; Medical Scientific Fund of the Mayor of Vienna, project 15205; SouthWestern Sydney Local Health District Academic Unit grant 2016; Western Sydney University AinsworthTrust grant 2019; Australia-Harvard Fellowship 2025<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db26-2148-p","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:48:29Z","timestamp":1780703309000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["2148-P: Subtyping Early GDM: Insulin-Resistant Early GDM Predicts Worse Pregnancy Outcomes but Benefits Most from Early Treatment"],"prefix":"10.2337","volume":"75","author":[{"given":"ARIANNE","family":"SWEETING","sequence":"first","affiliation":[{"name":"Sydney, Australia, Boston, MA, Hickory Creek, TX, Campbelltown, Australia, North Adelaide, Australia, Kingswood, Australia, Liverpool, Australia, Murdoch, Australia, Vienna, Austria, Scheibbs, Austria, Orebro, Sweden, Chennai, India, Woden, Australia, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIE-FRANCE","family":"HIVERT","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Boston, MA, Hickory Creek, TX, Campbelltown, Australia, North Adelaide, Australia, Kingswood, Australia, Liverpool, Australia, Murdoch, Australia, Vienna, Austria, Scheibbs, Austria, Orebro, Sweden, Chennai, India, Woden, Australia, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JINCY","family":"IMMANUEL","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Boston, MA, Hickory Creek, TX, Campbelltown, Australia, North Adelaide, Australia, Kingswood, Australia, Liverpool, Australia, Murdoch, Australia, Vienna, Austria, Scheibbs, Austria, Orebro, Sweden, Chennai, India, Woden, Australia, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANANDWARDHAN A.","family":"HARDIKAR","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Boston, MA, Hickory Creek, TX, Campbelltown, Australia, North Adelaide, Australia, Kingswood, Australia, Liverpool, Australia, Murdoch, Australia, Vienna, Austria, Scheibbs, Austria, Orebro, Sweden, Chennai, India, Woden, Australia, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NHAN HO TRONG","family":"PHAM","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Boston, MA, Hickory Creek, TX, Campbelltown, Australia, North Adelaide, Australia, Kingswood, Australia, Liverpool, Australia, Murdoch, Australia, Vienna, Austria, Scheibbs, Austria, Orebro, Sweden, Chennai, India, Woden, Australia, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WILLIAM M.","family":"HAGUE","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Boston, MA, Hickory Creek, TX, Campbelltown, Australia, North Adelaide, Australia, Kingswood, Australia, Liverpool, Australia, Murdoch, Australia, Vienna, Austria, Scheibbs, Austria, Orebro, Sweden, Chennai, India, Woden, Australia, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHAEL J.","family":"PEEK","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Boston, MA, Hickory Creek, TX, Campbelltown, Australia, North Adelaide, Australia, Kingswood, Australia, Liverpool, Australia, Murdoch, Australia, Vienna, Austria, Scheibbs, Austria, Orebro, Sweden, Chennai, India, Woden, Australia, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VINCENT W.M.","family":"WONG","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Boston, MA, Hickory Creek, TX, Campbelltown, Australia, North Adelaide, Australia, Kingswood, Australia, Liverpool, Australia, Murdoch, Australia, Vienna, Austria, Scheibbs, Austria, Orebro, Sweden, Chennai, India, Woden, Australia, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EMILY","family":"GIANATTI","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Boston, MA, Hickory Creek, TX, Campbelltown, Australia, North Adelaide, Australia, Kingswood, Australia, Liverpool, Australia, Murdoch, Australia, Vienna, Austria, Scheibbs, Austria, Orebro, Sweden, Chennai, India, Woden, Australia, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALEXANDRA","family":"KAUTZKY-WILLER","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Boston, MA, Hickory Creek, TX, Campbelltown, Australia, North Adelaide, Australia, Kingswood, Australia, Liverpool, Australia, Murdoch, Australia, Vienna, Austria, Scheibbs, Austria, Orebro, Sweden, Chennai, India, Woden, Australia, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00dcRGEN","family":"HARREITER","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Boston, MA, Hickory Creek, TX, Campbelltown, Australia, North Adelaide, Australia, Kingswood, Australia, Liverpool, Australia, Murdoch, Australia, Vienna, Austria, Scheibbs, Austria, Orebro, Sweden, Chennai, India, Woden, Australia, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HELENA E.","family":"BACKMAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Boston, MA, Hickory Creek, TX, Campbelltown, Australia, North Adelaide, Australia, Kingswood, Australia, Liverpool, Australia, Murdoch, Australia, Vienna, Austria, Scheibbs, Austria, Orebro, Sweden, Chennai, India, Woden, Australia, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VISWANATHAN","family":"MOHAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Boston, MA, Hickory Creek, TX, Campbelltown, Australia, North Adelaide, Australia, Kingswood, Australia, Liverpool, Australia, Murdoch, Australia, Vienna, Austria, Scheibbs, Austria, Orebro, Sweden, Chennai, India, Woden, Australia, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTOPHER","family":"NOLAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Boston, MA, Hickory Creek, TX, Campbelltown, Australia, North Adelaide, Australia, Kingswood, Australia, Liverpool, Australia, Murdoch, Australia, Vienna, Austria, Scheibbs, Austria, Orebro, Sweden, Chennai, India, Woden, Australia, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVID","family":"SIMMONS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Boston, MA, Hickory Creek, TX, Campbelltown, Australia, North Adelaide, Australia, Kingswood, Australia, Liverpool, Australia, Murdoch, Australia, Vienna, Austria, Scheibbs, Austria, Orebro, Sweden, Chennai, India, Woden, Australia, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/2148-P\/168698\/2148-P-Subtyping-Early-GDM-Insulin-Resistant-Early","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/2148-P\/168698\/2148-P-Subtyping-Early-GDM-Insulin-Resistant-Early","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:48:39Z","timestamp":1780703319000},"score":7.662721,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/2148-P\/168698\/2148-P-Subtyping-Early-GDM-Insulin-Resistant-Early"}},"issued":{"date-parts":[[2026,6,5]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2026,6,5]]}},"URL":"https:\/\/doi.org\/10.2337\/db26-2148-p","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2026,6,5]]},"article-number":"2148-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:17Z","timestamp":1753889777775,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"Introduction: Caring for young children with Type 1 diabetes comes with significant burden for parents. We hypothesised that pregnancy and the arrival of a new sibling may be associated with a deterioration in control of type 1 diabetes for older siblings with type 1 diabetes.<\/jats:p>\n Research Design and Methods: We identified young children currently under the care of the John Hunter Children's Hospital Paediatric Diabetes team who had welcomed a younger sibling since their diagnosis using our prospective Paediatric Diabetes database. We reviewed the HbA1c pre and post the arrival of a new sibling.<\/jats:p>\n Results: 38 children (20 male) had become older siblings since diagnosis of type 1 diabetes. 5 children were excluded as no data were available prior to pregnancy. Mean age of children at diagnosis was 3.5 years. Mean age at arrival of sibling was 6years with mean duration of diabetes at that time of 3.4 years. 15 of eligible participants were using insulin pump therapy. Mean HbA1c during pregnancy was 51mmol\/mol (6.8%) compared to 54mmol\/mol (7.1%) following delivery (p&lt;0.05). 67% of children had HbA1c &lt;53mmol\/mol (7%) during pregnancy compared to 53% following delivery.<\/jats:p>\n Conclusion: The arrival of a new sibling was associated with a significant increase in HbA1c. This may be due to the high care burden of type 1 diabetes on parents which cannot be met when also attempting to attend to the needs of a newborn. Programs to assist new parents may help children with young siblings to continue to meet glycaemic targets. Despite the young age of the cohort of children prior to delivery of a new sibling, 67% were able to meet the ADA glycaemic target of &lt;7%. This indicates that the goals of intensive management of diabetes are achievable even in the toddler, preschool and early primary school years.<\/jats:p>\n \n Disclosure<\/jats:title>\n P.E.Lopez: None. B.R.King: None. C.E.Smart: None. A.Sinclair: None. M.Neylan: None. R.Seckold: None. M.A.Paterson: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-1163-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:23:30Z","timestamp":1687242210000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1163-P: The Arrival of a New Sibling May Be Associated with a Deterioration in Glycemic Control for Children with Type 1 Diabetes"],"prefix":"10.2337","volume":"72","author":[{"given":"PRUDENCE E.","family":"LOPEZ","sequence":"first","affiliation":[{"name":"Newcastle, Australia, New Lambton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRUCE R.","family":"KING","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, New Lambton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARMEL E.","family":"SMART","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, New Lambton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANNE","family":"SINCLAIR","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, New Lambton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHELLE","family":"NEYLAN","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, New Lambton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROWEN","family":"SECKOLD","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, New Lambton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MEGAN A.","family":"PATERSON","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, New Lambton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1163-P\/150676\/1163-P-The-Arrival-of-a-New-Sibling-May-Be","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1163-P\/150676\/1163-P-The-Arrival-of-a-New-Sibling-May-Be","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T06:23:31Z","timestamp":1687242211000},"score":7.662598,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1163-P\/150676\/1163-P-The-Arrival-of-a-New-Sibling-May-Be"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-1163-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"1163-P"},{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:16:00Z","timestamp":1778717760024,"version":"3.51.4"},"reference-count":12,"publisher":"CSIRO Publishing","issue":"S1","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2026,5,14]]},"abstract":"Geoscience Australia, under the Australian Government\u2019s Resourcing Australia\u2019s Prosperity initiative and in collaboration with key Australian federal, state and territory organisations, is leading the development of a new, play-based national assessment of Australia\u2019s CO2 geological storage resources \u2013 the National Carbon Dioxide Storage Resource Atlas. The Atlas, to be delivered in late 2028, will provide detailed, pragmatic and consistent national-scale information about Australia\u2019s storage resources to help support policy and decision-making by governments, regulators, the carbon capture and storage (CCS) industry, researchers and the broader community. The Atlas builds on the substantial volume of work that has been completed across Australia over the past 25\u00a0years to deliver comprehensive and defensible national-scale information including: the location of potential storage resources; their quality and suitability for large-scale, near to medium-term storage; and the scale of CCS industry that could be realistically supported to help meet Australia\u2019s emissions reductions targets and maintain Australia at the forefront of the CCS industry. The assessment approach is based on the play-based exploration pyramid and is designed to be consistent with the CO2 Storage Resource Management System. This includes a tiered assessment process progressing from basin-scale assessments to play to prospect-scale evaluations in order to identify play fairways, prospects and assess injectivity and capacity in promising plays. Individual assessments will then be combined to produce a national-scale composite play fairways map.<\/jats:p>","DOI":"10.1071\/ep25161","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:56:48Z","timestamp":1778716608000},"source":"Crossref","is-referenced-by-count":0,"title":["Towards a pragmatic understanding of Australia\u2019s CO2 storage resources: introducing the National Carbon Dioxide Storage Resource Atlas"],"prefix":"10.1071","volume":"66","author":[{"given":"Aleksandra","family":"Kalinowski","sequence":"first","affiliation":[{"name":"AGeoscience Australia, Symonston, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Eid","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Symonston, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Chirinos","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Symonston, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Rees","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Symonston, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Patterson","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Symonston, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Owens","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Symonston, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Szczepaniak","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Symonston, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Feitz","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Symonston, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"2026051319564220800_R1","unstructured":"BGS (2011) The UK CO2 storage Atlas. Department of Energy and Climate Change, British Geological Survey."},{"key":"2026051319564220800_R2","unstructured":"Bradshaw B, Iwanec J, Beattie M, Bernecker T, Lund D (2024) Australia\u2019s future energy resources (AFER) project: assessment of the geological storage potential for carbon dioxide, Pedirka and western Eromanga basins. GA Record 2024\/30. Geoscience Australia, Canberra."},{"key":"2026051319564220800_R3","doi-asserted-by":"publisher","DOI":"10.1071\/EP24041","article-title":"Applying petrophysics and rock property modelling to enhance play-based assessments of the geological storage potential for carbon dioxide: western Eromanga Basin case study.","volume":"65","author":"Bradshaw","year":"2025","journal-title":"Australian Energy Producers Journal"},{"key":"2026051319564220800_R4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijggc.2022.103817","article-title":"Fetch-trap Pairs: exploring definition of carbon storage prospects to increase capacity and flexibility in areas with competing uses.","volume":"122","author":"Bump","year":"2023","journal-title":"International Journal of Greenhouse Gas Control"},{"key":"2026051319564220800_R6","unstructured":"GEODE (2023) Atlas of deep subsurface resources in the Netherlands. Available at https:\/\/www.geodeatlas.nl\/"},{"key":"2026051319564220800_R7","unstructured":"Geoscience Australia (2023) Trusted environmental and geological information program. Available at https:\/\/www.ga.gov.au\/about\/projects\/resources\/trusted-environmental-geological-information-program"},{"key":"2026051319564220800_R13"},{"key":"2026051319564220800_R8","unstructured":"GSWA (2025) CO2 Storage Atlas of Western Australia. Geological Survey of Western Australia."},{"key":"2026051319564220800_R9","unstructured":"Longley I, Dance T, Michael K, Clennell B (2025) Top-down site screening of Australia\u2019s North West Shelf. In \u2018Proceedings of the 2025 Southeast Asia Petroleum Exploration Society (SEAPEX) Conference\u2019, 6\u20139 May 2025, Singapore. (Southeast Asia Petroleum Exploration Society). Available at https:\/\/archives.datapages.com\/data\/southeast-asia-petroleum-exploration-society\/data\/034\/034001\/44_seapex0340044.htm"},{"key":"2026051319564220800_R10","unstructured":"NETL (2015) Carbon Storage Atlas V. National Energy Technology Laboratory, U.S. Department of Energy, Office of Fossil Energy and Carbon Management."},{"key":"2026051319564220800_R11","unstructured":"Royal Dutch Shell (2014) Play Based Exploration: A guide for AAPG\u2019s IBA Participants. AAPG Imperial Barrel Award. Royal Dutch Shell."},{"key":"2026051319564220800_R12","unstructured":"SPE (2025) CO2 Storage Resources Management System (SRMS). Society of Petroleum Engineers."}],"container-title":["Australian Energy Producers Journal"],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/doi\/10.1071\/EP25161\/1867174\/ep25161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/doi\/10.1071\/EP25161\/1867174\/ep25161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:56:50Z","timestamp":1778716610000},"score":7.662263,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/ep\/article\/66\/S1\/EP25161\/272115\/Towards-a-pragmatic-understanding-of-Australia-s"}},"issued":{"date-parts":[[2026,5,14]]},"references-count":12,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2026,5,14]]}},"URL":"https:\/\/doi.org\/10.1071\/ep25161","ISSN":["2982-0308"],"issn-type":[{"value":"2982-0308","type":"electronic"}],"published":{"date-parts":[[2026,5,14]]},"article-number":"EP25161"},{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:24:44Z","timestamp":1780089884200,"version":"3.54.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Gutsy Group Foundation, Australia"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,11]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>The impact of pregnancy on levels of biologic agents in patients with IBD is undefined and time to elimination in vedolizumab\u2010exposed infants is unknown.<\/jats:p><\/jats:sec>Aims<\/jats:title>To determine the effect of pregnancy on infliximab, adalimumab and vedolizumab levels and to study infant vedolizumab clearance<\/jats:p><\/jats:sec>Methods<\/jats:title>In a prospective observational study, maternal drug levels were measured pre\u2010conception, in each trimester, at delivery and postpartum. The association between drug levels and gestation in weeks was assessed using generalised estimating equation modelling. Infant vedolizumab levels were performed at birth (cord blood), 6\u00a0weeks and 3\u00a0months or until undetectable.<\/jats:p><\/jats:sec>Results<\/jats:title>We included 50 IBD patients (23 on infliximab, 15 on adalimumab and 12 on vedolizumab) with at least two intrapartum observations, plus 5 patients on vedolizumab with only mother and baby samples at delivery. Modelling showed no change in adalimumab levels, an increase in infliximab levels of 0.16 (95% CI 0.08\u20100.24) \u00b5g\/L\/week (P<\/jats:italic>\u00a0<\u00a00.001) and a decrease of 0.18 (95% CI: \u22120.33 to \u22120.02) \u00b5g\/L\/week (P<\/jats:italic>\u00a0=\u00a00.03) for vedolizumab. In 17 mother\u2010baby pairs, median infant vedolizumab levels at birth were lower than maternal levels (P<\/jats:italic>\u00a0<\u00a00.05) with an infant:maternal ratio of 0.7 (IQR 0.5\u20100.9). Vedolizumab was undetectable between 15 and 16\u00a0weeks of age in all 12 infants completing follow\u2010up testing.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>During pregnancy, adalimumab levels remain stable, while infliximab levels increase and vedolizumab levels decrease. However, the increments were small suggesting that intrapartum therapeutic drug monitoring and dose adjustment are not indicated. Unlike infliximab and adalimumab, infant vedolizumab levels are lower in cord blood than in mothers and appear to clear rapidly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16102","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T08:05:22Z","timestamp":1601625922000},"page":"1551-1562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Infliximab, adalimumab and vedolizumab concentrations across pregnancy and vedolizumab concentrations in infants following intrauterine exposure"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3911-4780","authenticated-orcid":false,"given":"Emma","family":"Flanagan","sequence":"first","affiliation":[{"name":"Fitzroy VIC Australia"},{"name":"Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9108-1712","authenticated-orcid":false,"given":"Peter R.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily K.","family":"Wright","sequence":"additional","affiliation":[{"name":"Fitzroy VIC Australia"},{"name":"Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3689-8858","authenticated-orcid":false,"given":"Gregory T.","family":"Moore","sequence":"additional","affiliation":[{"name":"Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2527-8044","authenticated-orcid":false,"given":"Miles P.","family":"Sparrow","sequence":"additional","affiliation":[{"name":"Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Connell","sequence":"additional","affiliation":[{"name":"Fitzroy VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-7199","authenticated-orcid":false,"given":"Michael A.","family":"Kamm","sequence":"additional","affiliation":[{"name":"Fitzroy VIC Australia"},{"name":"Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Begun","sequence":"additional","affiliation":[{"name":"Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8746-4275","authenticated-orcid":false,"given":"Britt","family":"Christensen","sequence":"additional","affiliation":[{"name":"Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3399-7236","authenticated-orcid":false,"given":"Peter","family":"De Cruz","sequence":"additional","affiliation":[{"name":"Parkville VIC Australia"},{"name":"Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Shelton","sequence":"additional","affiliation":[{"name":"Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Dowling","sequence":"additional","affiliation":[{"name":"Geelong VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane M.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Fitzroy VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-0422","authenticated-orcid":false,"given":"Olga","family":"Niewiadomski","sequence":"additional","affiliation":[{"name":"Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2840-0108","authenticated-orcid":false,"given":"Mark G.","family":"Ward","sequence":"additional","affiliation":[{"name":"Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ourania","family":"Rosella","sequence":"additional","affiliation":[{"name":"Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Rosella","sequence":"additional","affiliation":[{"name":"Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina V.","family":"Kiburg","sequence":"additional","affiliation":[{"name":"Fitzroy VIC Australia"},{"name":"Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyson L.","family":"Ross","sequence":"additional","affiliation":[{"name":"Fitzroy VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally J.","family":"Bell","sequence":"additional","affiliation":[{"name":"Fitzroy VIC Australia"},{"name":"Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The PICCOLO Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv234"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13960"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.10.013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001102"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1996.tb00172.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14040"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy058"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2014-100527"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12969"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284818783613"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2020.01.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals.2015.09.005"},{"key":"e_1_2_9_15_1","volume-title":"Comparative evaluation of four commercially available ELISA kits for therapeutic drug monitoring of adalimumab","author":"Sam M","year":"2018"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531248"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000212"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-018-0676-z"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544100-00001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318263"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15643"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284818772786"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1323-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-017-0546-0"},{"key":"e_1_2_9_25_1","first-page":"209","article-title":"Pharmacokinetics of monoclonal antibodies used for inflammatory bowel diseases in pregnant women","volume":"4","author":"Stone RH","year":"2014","journal-title":"J Clin Toxicol"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15027"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14837"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(16)30422-X"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.08.041"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13992"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.16102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.16102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T23:10:20Z","timestamp":1693869020000},"score":7.662229,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.16102"}},"issued":{"date-parts":[[2020,9,27]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/apt.16102"],"URL":"https:\/\/doi.org\/10.1111\/apt.16102","archive":["Portico"],"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"published":{"date-parts":[[2020,9,27]]},"assertion":[{"value":"2020-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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in reducing Alzheimer\u2019s disease (AD) risk. Higher adherence to the Mediterranean diet (MeDi) is linked to a lower incidence of mild cognitive impairment (MCI) and AD. Increasing evidence indicates the potential utility of a cytoskeletal protein found in astrocytes, plasma Glial Fibrillary Acidic Protein (GFAP), as a marker specific for AD pathogenesis. However, the relationship between plasma GFAP level and the MeDi has not been fully determined. This cross\u2010sectional study examined whether MeDi diet as a whole or the individual components, were associated with plasma GFAP levels in an Australian older adult cohort drawn from the larger Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing.<\/jats:p><\/jats:sec>Methods<\/jats:title>Cognitively unimpaired participants (n = 116) and individuals with MCI (n = 47) (mean age 75.37 \u00b1 6.31; 44% male) completed a self\u2010reported food frequency questionnaire and had plasma GFAP levels measured using SIMOA platform. A score for the MeDi was generated for each individual. Linear regression models evaluated the association between plasma GFAP and the MeDi score, as well as individual MeDi components, including sex and age as covariates.<\/jats:p><\/jats:sec>Results<\/jats:title>MeDi score was not associated with plasma GFAP level. However, for individual MeDi components, dairy intake was positively associated with GFAP level (\u03b2 = 0.107\u00b10.039, p<\/jats:italic> = 0.007).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This study is one of the first to report an association of plasma GFAP level with dietary components in an older adult cohort. The results suggest that dairy intake influences astrocyte reactivity. Further studies will include evaluation of plasma GFAP levels with additional dietary patterns, and individual dietary components to fully investigate the modifiable effect of diet on AD process.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.090245","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:46:42Z","timestamp":1736405202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of plasma glial fibrillary acidic protein (GFAP) and Mediterranean diet"],"prefix":"10.1002","volume":"20","author":[{"given":"E.M.S.","family":"Bandara","sequence":"first","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha L","family":"Gardener","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Murdoch University, Perth, Western Australia Australia"},{"name":"Alzheimer\u2019s Research Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Pedrini","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Australian Alzheimer\u2019s Research Foundation, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Hone","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Australian Alzheimer's Research Foundation, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie Rainey","family":"Smith","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Australian Alzheimer\u2019s Research Foundation, Perth, Western Australia Australia"},{"name":"Centre for Healthy Ageing, Murdoch University, Murdoch, Western Australia Australia"},{"name":"Murdoch University, Murdoch, Western Australia Australia"},{"name":"School of Psychological Science, University of Western Australia, Crawley, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph N","family":"Martins","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Alzheimer\u2019s Research Australia, Perth, Western Australia Australia"},{"name":"Department of Biomedical Sciences, Macquarie University, Macquarie Park, NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warnakulasuriya Mary Ann Dipika Binosha","family":"Fernando","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Australian Alzheimer\u2019s Research Foundation, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,9]]},"container-title":["Alzheimer's & 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Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534717308455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534717308455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2017.02.621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:37:24Z","timestamp":1651210644000},"score":7.6610775,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2017.02.621"}},"issued":{"date-parts":[[2017,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1016\/j.juro.2017.02.621"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2017.02.621","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2017,4]]}},{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T09:53:09Z","timestamp":1773568389355,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"10S","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthroscopy"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.arthro.2011.08.183","type":"journal-article","created":{"date-parts":[[2011,10,15]],"date-time":"2011-10-15T17:16:05Z","timestamp":1318698965000},"source":"Crossref","is-referenced-by-count":0,"title":["Paper # 183: Arthroscopic Matrix\u2010Induced Autologous Chondrocyte Implantation (MACI)"],"prefix":"10.1002","volume":"27","author":[{"given":"Greg","family":"Janes","sequence":"first","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay Robert","family":"Ebert","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Carey\u2010Smith","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fallon","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hywel","family":"Davies","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Garrett","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Wood","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia AUSTRALIA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,1]]},"container-title":["Arthroscopy"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806311008930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749806311008930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2011.08.183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.arthro.2011.08.183","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.arthro.2011.08.183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T08:50:23Z","timestamp":1773564623000},"score":7.661013,"resource":{"primary":{"URL":"https:\/\/arthroscopyjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.arthro.2011.08.183"}},"issued":{"date-parts":[[2011,10]]},"references-count":0,"journal-issue":{"issue":"10S","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1016\/j.arthro.2011.08.183"],"URL":"https:\/\/doi.org\/10.1016\/j.arthro.2011.08.183","archive":["Portico"],"ISSN":["0749-8063","1526-3231"],"issn-type":[{"value":"0749-8063","type":"print"},{"value":"1526-3231","type":"electronic"}],"published":{"date-parts":[[2011,10]]}},{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T08:38:06Z","timestamp":1771058286455,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100023759","name":"Telethon Kids Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023759","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabet Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Children and young people with type 1 diabetes (T1D) experience high rates of mental ill health and stress due to the emotional and cognitive energy required to manage their condition. Our team has codesigned Wellbeing T1D, a brief trauma\u2010informed online intervention for adolescents living with T1D. This 5\u2010week intervention will teach skills to promote problem solving, improve emotional regulation and promote helpful thinking and coping.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n The aim of this project is to pilot the Wellbeing project with Australian adolescents, aged 13\u201317\u2009years. The feasibility and potential effectiveness of the intervention will be evaluated. We hypothesise that the Wellbeing project will show efficacy in improving the well\u2010being, resilience and coping skills of adolescents with T1D.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A double arm, pre\u2013post longitudinal study design will be employed, with an intervention group and a non\u2010intervention group receiving treatment as usual, to determine the potential effectiveness of the intervention content and delivery. We aim to recruit approximately 40 adolescents, at least 6\u2009months post\u2010T1D diagnosis, to take part in the intervention. We will measure changes in participants' level of optimism, self\u2010compassion and diabetes\u2010specific distress and resilience at three timepoints.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This protocol outlines the first trauma\u2010informed intervention aimed at addressing symptoms of traumatic stress in this population. Wellbeing T1D has the potential to be used in a variety of settings (both clinical and non\u2010clinical) to reduce the disease burden on adolescents living with T1D and their families, improve long\u2010term mental health outcomes and ultimately reduce morbidity from diabetes and its other physical complications.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dme.70148","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T03:56:12Z","timestamp":1760154972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A randomised trial of a trauma\u2010informed well\u2010being program to promote mental health in adolescents with type 1 diabetes: Study protocol"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8016-2197","authenticated-orcid":false,"given":"K.","family":"Lombardi","sequence":"first","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"},{"name":"School of Population and Global Health The University of Western Australia Crawley Western Australia Australia"},{"name":"School of Medical and Health Science Edith Cowan University Joondalup Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2947-988X","authenticated-orcid":false,"given":"R.","family":"Paciente","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"},{"name":"Medical School The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7751-4700","authenticated-orcid":false,"given":"S.","family":"Coombs","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7202-7187","authenticated-orcid":false,"given":"N.","family":"Hanna","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6932-3375","authenticated-orcid":false,"given":"H.","family":"Milroy","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"},{"name":"Medical School The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4801-4239","authenticated-orcid":false,"given":"J.","family":"Ohan","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"},{"name":"School of Psychological Science The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Perth Children's Hospital Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-0573","authenticated-orcid":false,"given":"K.","family":"Bebbington","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2844-0484","authenticated-orcid":false,"given":"H. C.","family":"Roby","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8797-2926","authenticated-orcid":false,"given":"C. E.","family":"Taplin","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"},{"name":"Department of Endocrinology and Diabetes Perth Children's Hospital Nedlands Western Australia Australia"},{"name":"Centre for Child Health Research The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3427-351X","authenticated-orcid":false,"given":"A.","family":"Woolard","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"},{"name":"Medical School The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2013.01.006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2021.06.019"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-015-0694-2"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajcp.12392"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12021"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13381"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-38-13"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13065"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13428"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0294237"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_12_13_1","unstructured":"Genially.Genially E\u2010Learning Platform.2024.https:\/\/genially.com\/"},{"key":"e_1_2_12_14_1","unstructured":"Microsoft.Manage Teams Recording Policies for Meetings and Events. Microsoft.https:\/\/learn.microsoft.com\/en\u2010us\/microsoftteams\/meeting\u2010recording2025."},{"key":"e_1_2_12_15_1","volume-title":"R: a language and environment for statistical computing","year":"2020"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-0753-5_2465"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2009.02.002"}],"container-title":["Diabetic Medicine"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dme.70148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T15:11:12Z","timestamp":1763565072000},"score":7.6608953,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dme.70148"}},"issued":{"date-parts":[[2025,10,10]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/dme.70148"],"URL":"https:\/\/doi.org\/10.1111\/dme.70148","archive":["Portico"],"ISSN":["0742-3071","1464-5491"],"issn-type":[{"value":"0742-3071","type":"print"},{"value":"1464-5491","type":"electronic"}],"published":{"date-parts":[[2025,10,10]]},"assertion":[{"value":"2025-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70148"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:26Z","timestamp":1753889846062,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Background: To manage hyperglycemia following high fat and protein (HFHP) meals, T1D guidelines recommend additional mealtime insulin. However, guidance regarding dosing adjustments for HFHP meals is unclear.<\/jats:p>\n Aim: To determine the amount of additional insulin required for a HFHP meal to optimise 6 h postprandial glucose, in young people with T1D using insulin pumps.<\/jats:p>\n Method: This was a 4x4 crossover trial conducted at 2 centers in Australia. On 4 days, participants (n=27) with mean age 14.5 \u00b1 3.6 yrs and HbA1c 53 mmol\/mol (7.0 \u00b1 0.7%) ate a HFHP meal [carbohydrate (CHO) 30g, fat 40g, protein 50g]. Insulin based on the CHO: insulin ratio (CIR) was given in random order: 100% (control), 120%, 140%, 160% CIR. Postprandial sensor glucose was measured for 6 h.<\/jats:p>\n Results: Compared to 100% CIR, 140% and 160% CIR resulted in significantly lower mean glucose excursions from 90- 360 min (p\u2264 0.018) and mean peak glucose excursions (4.0 and 2.7 v 6.0 mmol\/L, p&lt; 0.001). Hypoglycemia for 100%- 160% CIR was 7.7%, 7.7%, 12.0% and 19.2% respectively (p\u2265 0.139). With increasing insulin there was a dose-dependent reduction in mean glucose excursions from 60- 360 min (p&lt; 0.01).<\/jats:p>\n Conclusions: Incremental addition of mealtime insulin for fat and protein produces a dose- dependent improvement in postprandial glycemia. For HFHP meals, 140% CIR is advised with titration based on individual glucose response.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n T.A. Smith: None. C.E. Smart: None. M.E. Fuery: None. B. Knight: None. P. Howley: None. B.R. King: Other Relationship; Self; Menarini Group.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Australasian Paediatric Endocrine Group<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-346-or","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:52Z","timestamp":1592238592000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["346-OR: In Young People with T1D, Additional Mealtime Insulin Produces a Dose-Dependent Improvement in Glycemia after a High-Fat, High-Protein Meal"],"prefix":"10.2337","volume":"69","author":[{"given":"TENELE A.","family":"SMITH","sequence":"first","affiliation":[{"name":"Newcastle, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARMEL E.","family":"SMART","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHELLE E.","family":"FUERY","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRIGID","family":"KNIGHT","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER","family":"HOWLEY","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRUCE R.","family":"KING","sequence":"additional","affiliation":[{"name":"Newcastle, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/346-OR\/56278\/346-OR-In-Young-People-with-T1D-Additional","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/346-OR\/56278\/346-OR-In-Young-People-with-T1D-Additional","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:28:32Z","timestamp":1647163712000},"score":7.6601853,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/346-OR\/56278\/346-OR-In-Young-People-with-T1D-Additional"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-346-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"346-OR"},{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:13Z","timestamp":1787013853069,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2023,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n This study aimed to examine the performance of machine learning algorithms for the prediction of discharge within 12 and 24\u2009h to produce a measure of readiness for discharge after general surgery.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Consecutive general surgery patients at two tertiary hospitals, over a 2\u2010year period, were included. Observation and laboratory parameter data were stratified into training, testing and validation datasets. Random forest, XGBoost and logistic regression models were evaluated. Each ward round note time was taken as a different event. Primary outcome was classification accuracy of the algorithmic model able to predict discharge within the next 12\u2009h on the validation data set.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n 42\u2009572 ward round note timings were included from 8826 general surgery patients. Discharge occurred within 12\u2009h for 8800 times (20.7%), and within 24\u2009h for 9885 (23.2%). For predicting discharge within 12\u2009h, model classification accuracies for derivation and validation data sets were: 0.84 and 0.85 random forest, 0.84 and 0.83 XGBoost, 0.80 and 0.81 logistic regression. For predicting discharge within 24\u2009h, model classification accuracies for derivation and validation data sets were: 0.83 and 0.84 random forest, 0.82 and 0.81 XGBoost, 0.78 and 0.79 logistic regression. Algorithms generated a continuous number between 0 and 1 (or 0 and 100), representing readiness for discharge after general surgery.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n A derived artificial intelligence measure (the Adelaide Score) successfully predicts discharge within the next 12 and 24\u2009h in general surgery patients. This may be useful for both treating teams and allied health staff within surgical systems.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ans.18546","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T06:26:41Z","timestamp":1685687201000},"page":"2119-2124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The Adelaide Score: An artificial intelligence measure of readiness for discharge after general surgery"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3880-3840","authenticated-orcid":false,"given":"Joshua G.","family":"Kovoor","sequence":"first","affiliation":[{"name":"Queen Elizabeth Hospital University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Australasian College of Surgeons Adelaide South Australia Australia"},{"name":"Health and Information Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Bacchi","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-0378","authenticated-orcid":false,"given":"Aashray K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Gold Coast University Hospital Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-3489","authenticated-orcid":false,"given":"Brandon","family":"Stretton","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital University of Adelaide Adelaide South Australia Australia"},{"name":"Health and Information Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Malycha","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Reddi","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Liew","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick G.","family":"O'Callaghan","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Beltrame","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Zannettino","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Jones","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Horowitz","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Dobbins","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Hewett","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus I.","family":"Trochsler","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-181X","authenticated-orcid":false,"given":"Guy J.","family":"Maddern","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Australasian College of Surgeons Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128356"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.24.5.1103"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0307-0"},{"key":"e_1_2_9_5_1","unstructured":"Royal Australasian College of Surgeons.Surgical Audit Guide. [Cited 18 May 2023]. Available from URL:https:\/\/www.surgeons.org\/-\/media\/Project\/RACS\/surgeons-org\/files\/reports-guidelines-publications\/manuals-guidelines\/surgical-audit-and-peer-review-guide.pdf"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.18201"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.4952"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_9_9_1","volume-title":"Census of population and housing: socio\u2010economic indexes for areas (SEIFA)","author":"Australian Bureau of Statistics","year":"2016"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.11.011"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.07.385"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181e495c2"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znab315"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa0810119"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32519-8"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjsopen\/zrab048"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.18263"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.17217"}],"container-title":["ANZ Journal of Surgery"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.18546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T01:10:12Z","timestamp":1694740212000},"score":7.6596537,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.18546"}},"issued":{"date-parts":[[2023,6]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/ans.18546"],"URL":"https:\/\/doi.org\/10.1111\/ans.18546","archive":["Portico"],"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2023-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T23:33:47Z","timestamp":1773444827044,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001801","name":"University of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Antigen\u2010specific IgE binds the Fc\u03b5 receptor I (Fc\u03b5RI) expressed on several types of immune cells, including dendritic cells (DCs). Activation of Fc\u03b5RI on DCs in atopics has been shown to modulate immune responses that potentially contribute to asthma development. However, the extent to which DC subsets differ in Fc\u03b5RI expression between atopic children with or without asthma is currently not clear. This study aimed to analyse the expression of Fc\u03b5RI on peripheral blood mononuclear cells (PBMCs) from atopic children with and without asthma, and non\u2010atopic\/non\u2010asthmatic age\u2010matched healthy controls.<\/jats:p><\/jats:sec>Methods<\/jats:title>We performed multiparameter flow cytometry on PBMC from 391 children across three community cohorts and one clinical cohort based in Western Australia.<\/jats:p><\/jats:sec>Results<\/jats:title>We confirmed expression of Fc\u03b5RI on basophils, monocytes, plasmacytoid and conventional DCs, with higher proportions of all cell populations expressing Fc\u03b5RI in atopic compared to non\u2010atopic children. Further, we observed that levels of Fc\u03b5RI expression were elevated across plasmacytoid and conventional DC as well as basophils in atopic asthmatic compared to atopic non\u2010asthmatic children also after adjusting for serum IgE levels.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our data suggest that the expression pattern of Fc\u03b5RI on DC and basophils differentiates asthmatic from non\u2010asthmatic atopic children. Given the significant immune modulatory effects observed as a consequence of Fc\u03b5RI expression, this altered expression pattern is likely to contribute to asthma pathology in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.13063","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T15:09:55Z","timestamp":1555340995000},"page":"646-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Progressive increase of Fc\u03b5RI expression across several PBMC subsets is associated with atopy and atopic asthma within school\u2010aged children"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5674-8462","authenticated-orcid":false,"given":"Jonatan","family":"Leffler","sequence":"first","affiliation":[{"name":"Telethon Kids Institute University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Read","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia Nedlands Western Australia Australia"},{"name":"School of Medicine University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anya C.","family":"Jones","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia Nedlands Western Australia Australia"},{"name":"School of Medicine University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny","family":"Mok","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elysia M.","family":"Hollams","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid A.","family":"Laing","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia Nedlands Western Australia Australia"},{"name":"School of Medicine University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter N.","family":"Le Souef","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia Nedlands Western Australia Australia"},{"name":"School of Medicine University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Sly","sequence":"additional","affiliation":[{"name":"Child Health Research Centre University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merci M.H.","family":"Kusel","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas H.","family":"de Klerk","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Bosco","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick G.","family":"Holt","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia Nedlands Western Australia Australia"},{"name":"Child Health Research Centre University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah H.","family":"Strickland","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12534"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.25"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012204"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2273"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81300-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.154.12.6285"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1365-2249.2010.04162.x","article-title":"Human skin and oral mucosal dendritic cells as \u2018good guys\u2019 and \u2018bad guys\u2019 in allergic immune responses","volume":"16","author":"Novak N","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68964"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2007.03.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901194"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.023"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2768"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032556"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70033-2"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02954.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.12.669"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.108985"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91944-H"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00103602"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0498OC"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.07.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22625"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13157"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.011"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.006"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2236"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13265"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.10.016"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00203412"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.09.008"}],"container-title":["Pediatric Allergy and Immunology"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.13063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.13063","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.13063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T19:21:11Z","timestamp":1693423271000},"score":7.659367,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.13063"}},"issued":{"date-parts":[[2019,5,22]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/pai.13063"],"URL":"https:\/\/doi.org\/10.1111\/pai.13063","archive":["Portico"],"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"published":{"date-parts":[[2019,5,22]]},"assertion":[{"value":"2018-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:38:45Z","timestamp":1753889925873,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: Ethnicity plays a significant role in the prevalence of prediabetes and diabetes, yet no comprehensive studies have explored this in Australia. This study aims to systematically review and meta-analyze ethnic differences in the prevalence of diabetes and prediabetes in Australia.<\/jats:p>\n Methods: In July-August 2024, a comprehensive search of cross-sectional and observational studies published between 2010 and 2024 in MEDLINE, EMBASE, Scopus, CINAHL, and Web of Science was conducted. Studies that reported the prevalence of diabetes and prediabetes in adults from various ethnic groups in Australia were included, while those focused on pregnant women and individuals under 18 were excluded.<\/jats:p>\n Results: Of 2,838 studies, 28 studies involving 1,137,925 participants were reviewed. In 46.2% of studies, diabetes diagnoses were based on self-reported data. The pooled weighted prevalence was 21.8% (95% CI: 20.60-23.01) for diabetes and 13.7% (CI: 10.42-17.02) for prediabetes. Oceanians or Pacific Islanders (36.5%, CI: 15.20-57.86) and Indigenous Australians (30.7%, CI: 23.90-37.49) had the highest pooled weighted prevalence of diabetes, while the lowest was in Caucasians (14.5%, CI: 13.03-16.01) and non-Indigenous Australians (18.6%, CI: 20.83-23.24). Significant heterogeneity (I2 = 99.9%, p&lt; 0.05) was observed among studies.<\/jats:p>\n Conclusion: Approximately one in five and one in six people in Australia had diabetes and prediabetes, respectively, but this varied significantly between ethnic groups. Diabetes prevalence was highest in Oceanians and Indigenous Australians but lowest in Caucasians. The substantial heterogeneity calls for a more comprehensive, population-based study to better understand these disparities and guide targeted public health interventions for at-risk ethnic groups.<\/jats:p>\n \n Disclosure<\/jats:title>\n N.E. Ezinne: None. U.L. Osuagwu: None. K.E. Agho: None. A. Doyle: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-1477-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:47:43Z","timestamp":1749793663000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1477-P: Ethnic Disparities in the Prevalence of Diabetes and Prediabetes in Australia\u2014A Systematic Review and Meta-analysis"],"prefix":"10.2337","volume":"74","author":[{"given":"NGOZIKA E.","family":"EZINNE","sequence":"first","affiliation":[{"name":"Bathurst, Australia, Campbelltown, Australia, Sydney, Australia, Western Sydney University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"UCHECHUKWU L.","family":"OSUAGWU","sequence":"additional","affiliation":[{"name":"Bathurst, Australia, Campbelltown, Australia, Sydney, Australia, Western Sydney University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KINGSLEY E.","family":"AGHO","sequence":"additional","affiliation":[{"name":"Bathurst, Australia, Campbelltown, Australia, Sydney, Australia, Western Sydney University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AUNTY-KERRIE","family":"DOYLE","sequence":"additional","affiliation":[{"name":"Bathurst, Australia, Campbelltown, Australia, Sydney, Australia, Western Sydney University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1477-P\/159275\/1477-P-Ethnic-Disparities-in-the-Prevalence-of","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1477-P\/159275\/1477-P-Ethnic-Disparities-in-the-Prevalence-of","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T16:18:35Z","timestamp":1750436315000},"score":7.658947,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1477-P\/159275\/1477-P-Ethnic-Disparities-in-the-Prevalence-of"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-1477-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"1477-P"},{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:28:49Z","timestamp":1788989329990,"version":"build-2803163510"},"reference-count":38,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"unspecified","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012155","name":"Channel 7 Telethon Trust","doi-asserted-by":"publisher","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}],"id":[{"id":"10.13039\/100012155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT 1119339"],"award-info":[{"award-number":["GNT 1119339"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT 1175509"],"award-info":[{"award-number":["GNT 1175509"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Western Australian Department of Health","award":["DoH20205875"],"award-info":[{"award-number":["DoH20205875"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,10,28]]},"published-print":{"date-parts":[[2022,1]]},"abstract":"\n Objectives<\/jats:title>\n When the COVID-19 pandemic was declared, Governments responded with lockdown and isolation measures to combat viral spread, including the closure of many schools. More than a year later, widespread screening for SARS-CoV-2 is critical to allow schools and other institutions to remain open. Here, we describe the acceptability of a minimally invasive COVID-19 screening protocol trialled by the Western Australian Government to mitigate the risks of and boost public confidence in schools remaining open. To minimise discomfort, and optimise recruitment and tolerability in unaccompanied children, a combined throat and nasal (OP\/Na) swab was chosen over the nasopharyngeal swab commonly used, despite slightly reduced test performance.<\/jats:p>\n <\/jats:sec>\n \n Design, setting and participants<\/jats:title>\n Trialling of OP\/Na swabbing took place as part of a prospective observational cohort surveillance study in 79 schools across Western Australia. Swabs were collected from 5903 asymptomatic students and 1036 asymptomatic staff in 40 schools monthly between June and September 2020.<\/jats:p>\n <\/jats:sec>\n \n Outcome measures<\/jats:title>\n PCR testing was performed with a two-step diagnostic and independent confirmatory PCR for any diagnostic PCR positives. Concurrent surveys, collected online through the REDCap platform, evaluated participant experiences of in-school swabbing.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n 13 988 swabs were collected from students and staff. There were zero positive test results for SARS-CoV-2, including no false positives. Participants reported high acceptability: 71% of students reported no or minimal discomfort and most were willing to be reswabbed (4% refusal rate).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n OP\/Na swabbing is acceptable and repeatable in schoolchildren as young as 4 years old and may combat noncompliance rates by significantly increasing the acceptability of testing. This kind of minimally-invasive testing will be key to the success of ongoing, voluntary mass screening as society adjusts to a new \u2018normal\u2019 in the face of COVID-19.<\/jats:p>\n <\/jats:sec>\n \n Trial registration number<\/jats:title>\n Australian New Zealand Clinical Trials Registry\u2014ACTRN12620000922976.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2021-055217","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T09:35:13Z","timestamp":1643189713000},"page":"e055217","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Acceptability of OP\/Na swabbing for SARS-CoV-2: a prospective observational cohort surveillance study in Western Australian schools"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3699-7714","authenticated-orcid":false,"given":"Hannah M","family":"Thomas","sequence":"first","affiliation":[{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"},{"name":"Wesfarmers Centre of Vaccines & Infectious Diseases, Telethon Kids Institute, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne J","family":"Mullane","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"},{"name":"Wesfarmers Centre of Vaccines & Infectious Diseases, Telethon Kids Institute, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherlynn","family":"Ang","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Barrow","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Leahy","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"},{"name":"Wesfarmers Centre of Vaccines & Infectious Diseases, Telethon Kids Institute, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Whelan","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"},{"name":"Wesfarmers Centre of Vaccines & Infectious Diseases, Telethon Kids Institute, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"},{"name":"Edith Cowan University, Joondalup, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Cooper","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne","family":"Lester","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Padley","sequence":"additional","affiliation":[{"name":"Child and Adolescent Health Service, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Sprigg","sequence":"additional","affiliation":[{"name":"Child and Adolescent Health Service, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Speers","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"},{"name":"PathWest Laboratory Medicine Western Australia, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J","family":"Merritt","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine Western Australia, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli","family":"Coffin","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"},{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Cross","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"},{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gething","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"},{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha C","family":"Bowen","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"},{"name":"Wesfarmers Centre of Vaccines & Infectious Diseases, Telethon Kids Institute, Nedlands, Western Australia, Australia"},{"name":"University of Western Australia, Perth, Western Australia, 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ODX is available in Australia, but is self-funded by patients (\u223cUSD 4175), so its use is limited. We sought to evaluate the impact of self-funded ODX on TRs. A high proportion of TR changes would imply a benefit to the broader community if ODX testing were available to all appropriately selected patients.<\/jats:p>\n Methods:<\/jats:p>\n All Australian physicians who had ordered &gt;5 ODX were invited to participate. Data collected included demographics, tumor characteristics, indication for ODX (confirm need for chemotherapy (CT), confirm omission of CT, or genuine equipoise). Pre- and post Recurrence Score (RS) TRs (CT recommended versus hormone therapy alone (HT)) were also collected. The primary endpoint was the frequency and predictors of TR change. Relationships between categorical variables were assessed using Chi2 test and logistic regression analysis determined factors associated with TR change post-ODX.<\/jats:p>\n Results:<\/jats:p>\n 382 patients with median age 54 (range 31-76) were included. 18 physicians contributed a median of 17 (5-87) patients. Tumor characteristics were: T1 232 (61%); \u2265T2 150 (39%); grade 1 49 (13%), grade 2 252 (66%) and grade 3 79 (21%) and Ki67&gt;15% in 131\/231 (49%). 257 (67%) were node negative (N0). Assay indications were: confirm need for CT in 36%, confirm omission of CT in 40% and genuine equipoise in 24%. RS was low in 55%, intermediate in 36% and high in 9%.<\/jats:p>\n Of 355 patients with a TR recorded pre-ODX, 38% had TR change post-ODX. 109\/168 patients (65%) recommended CT pre-ODX changed to HT alone, and this was more likely if lower grade (82.1% vs 50.8% p&lt;0.001) and less likely if ER and\/or PR\u226410% (12% vs 25% p=0.03). 27\/187 (14%) with pre-ODX TR for HT alone changed to CT, and this was more likely if ER and\/or PR\u226410% (27.6% vs 11.5% p=0.02) and if Ki67 &gt;15% (27.5% vs 9.8% p=0.015). Overall, TR for CT decreased from 47% to 24%.<\/jats:p>\n Influence of adverse prognostic factors (defined as \u2265T2, grade 3, ER and\/or PR &lt;10%, nodal macrometastasis) on TR is tabulated. In 348 patients with complete data, TR changed in 31% (72\/234) of N0 and 53% (60\/114) of node positive (N+) patients.<\/jats:p>\n \u00a0Number of \"adverse factors\"01234N0 (n=234)Number of patients90116244\u00a0\u00a0RS median (range)16 (0-40)17 (0-41)26 (5-52)31 (22-40)\u00a0\u00a0TR change19\/90 (21%)45\/116 (39%)6\/24 (25%)2\/4\u00a0\u00a0HT to CT7\/71 (10%)10\/61 (16%)2\/11 (18%)1\/2\u00a0\u00a0CT to HT12\/19 (63%)35\/55 (64%)4\/13 (31%)1\/2\u00a0N+ (n=114)Number of patients22424181\u00a0RS median (range)14 (5-34)16 (0-38)14 (0-32)24 (12-50)39\u00a0TR change11\/22 (50%)21\/42 (50%)25\/41 (42%)3\/8 (38%)0\/1\u00a0HT to CT3\/13 (23%)3\/14 (21%)0\/12NANA\u00a0CT to HT8\/9 (89%)18\/28 (64%)25\/29 (86%)3\/7 (43%)0\/1<\/jats:p>\n Conclusions:<\/jats:p>\n Patient self-funded ODX changed TRs in 38%. 65% who would have been recommended CT pre-ODX were spared CT post-ODX, suggesting that traditional histopathological indications for CT in ER+ patients has led to many receiving CT unnecessarily. Where the pre ODX TR was HT alone, only 14% changed to adding CT, suggesting that the indication was reassurance that CT could be omitted. Consideration could be made for third party funding in select patient groups.<\/jats:p>\n Citation Format: Chin-Lenn L, Segelov E, De Boer R, Marx G, Hughes TM, McCarthy N, White S, Foo S, Rutovitz J, Della Fiorentina S, Jennens R, Antill Y, Tsoi D, Cronk M, Lombard J, Kiely BE, Chirgwin J, Gorelik A, Mann GB. Indications for, and impact of oncotype DX on adjuvant treatment recommendations when third party funding is unavailable. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P5-15-02.<\/jats:p>","DOI":"10.1158\/1538-7445.sabcs15-p5-15-02","type":"journal-article","created":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T08:49:58Z","timestamp":1463734198000},"page":"P5-15-02-P5-15-02","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Abstract P5-15-02: Indications for, and impact of oncotype DX on adjuvant treatment recommendations when third party funding is unavailable"],"prefix":"10.1158","volume":"76","author":[{"given":"L","family":"Chin-Lenn","sequence":"first","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Segelov","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"De Boer","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Marx","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TM","family":"Hughes","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"White","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Foo","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Rutovitz","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Della Fiorentina","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Jennens","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Antill","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Tsoi","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Cronk","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Lombard","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BE","family":"Kiely","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Chirgwin","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Gorelik","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GB","family":"Mann","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, Sydney, Victoria, Australia; Sydney Adventist Hospital, Australia; ICON Cancercare Wesley, Australia; Austin Health, Australia; Epworth Eastern Hospital, Australia; St Vincent's Private Hospital, Australia; Northern Haematology and Oncology Group, Australia; Macarthur Cancer Therapy Centre, Australia; Peter MacCallum Cancer Centre, Australia; Cabrini Health, Australia; University of Notre Dame Australia, Australia; Sunshine Coast Hospital and Health Services, Australia; Calvary Mater Newcastle, Australia; Eastern Health, Australia; Royal Women's Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/76\/4_Supplement\/P5-15-02\/615233\/Abstract-P5-15-02-Indications-for-and-impact-of","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/76\/4_Supplement\/P5-15-02\/615233\/Abstract-P5-15-02-Indications-for-and-impact-of","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T19:08:44Z","timestamp":1656097724000},"score":7.657077,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/76\/4_Supplement\/P5-15-02\/615233\/Abstract-P5-15-02-Indications-for-and-impact-of"}},"issued":{"date-parts":[[2016,2,15]]},"references-count":0,"journal-issue":{"issue":"4_Supplement","published-print":{"date-parts":[[2016,2,15]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.sabcs15-p5-15-02","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2016,2,15]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:37Z","timestamp":1753890037019,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Impaired angiogenic responses to ischemia characterize the vascular complications associated with diabetes. Diabetic foot ulcers in the presence of ischemia are associated with the most severe outcomes, including a higher rate of mortality and lower probability of healing. Specific micro-RNAs (miRNAs) such as miRNA-200b have been shown to negatively regulate angiogenesis in ischemia. Therefore, we sought to investigate miRNA-200b as a target and biomarker of diabetes-impaired angiogenesis. To assess the importance of miRNA-200b in diabetes-impaired angiogenesis, we transfected endothelial cells with anti-miRNA-200b or anti-miRNA-Neg then performed a functional tubulogenesis assay under high glucose and hypoxic conditions. High glucose impaired tubule formation by 23.6% in response to hypoxia when compared to controls (51.9\u00b115.4 vs. 39.7\u00b123.2, P&lt;0.005), this decrease was prevented by anti-miRNA-200b treatment. Furthermore, in an in vivo hind-limb ischemia model, diabetic mice (n=8-11\/group) were injected intramuscularly with anti-miRNA-200b or anti-miRNA-Neg at the time of hind-limb ischemia surgery. Diabetes impaired blood flow reperfusion was assessed by laser Doppler perfusion imaging (LDPI) in anti-miRNA-Neg control mice (LDPI: 0.27), and this was rescued by inhibition of miRNA-200b to nondiabetic levels (LDPI: 0.41, P&lt;0.05). To assess the utility of miRNA-200b as a biomarker of delayed healing, plasma miRNA-200b was measured in a rodent excisional wound model. When compared to controls, diabetes elevated plasma miRNA-200b in both unwounded and wounded animals, suggesting a diabetes related change. Whether this change is seen in humans remains to be investigated.<\/jats:p>\n In conclusion, this study has identified that miRNA-200b is a potential target of diabetes-impaired angiogenesis as shown in this preclinical model of predominant ischemia in a diabetes setting.<\/jats:p>\n \n Disclosure<\/jats:title>\n C. Cannizzo: None. E. Solly: None. L.F. Olaya: None. M. Abdollahi: None. S.S. Sutanto: None. S.M. Twigg: Advisory Panel; Self; Abbott, AstraZeneca, Sanofi. Speaker\u2019s Bureau; Self; Abbott, AstraZeneca, Novo Nordisk Inc., Roche Diabetes Care, Sanofi. C. Bursill: None. J.T. Tan: None. S. McLennan: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-90-or","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:38:49Z","timestamp":1592239129000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["90-OR: Inhibition of miRNA-200b Rescues Diabetes-Impaired Angiogenesis"],"prefix":"10.2337","volume":"69","author":[{"given":"CARLA","family":"CANNIZZO","sequence":"first","affiliation":[{"name":"Adelaide, Australia, Duarte, CA, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EMMA","family":"SOLLY","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Duarte, CA, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUISA F.","family":"OLAYA","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Duarte, CA, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARYAM","family":"ABDOLLAHI","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Duarte, CA, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SURYA S.","family":"SUTANTO","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Duarte, CA, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN M.","family":"TWIGG","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Duarte, CA, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTINA","family":"BURSILL","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Duarte, CA, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOANNE T.","family":"TAN","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Duarte, CA, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUSAN","family":"MCLENNAN","sequence":"additional","affiliation":[{"name":"Adelaide, Australia, Duarte, CA, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/90-OR\/56790\/90-OR-Inhibition-of-miRNA-200b-Rescues-Diabetes","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/90-OR\/56790\/90-OR-Inhibition-of-miRNA-200b-Rescues-Diabetes","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:49:36Z","timestamp":1647164976000},"score":7.65651,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/90-OR\/56790\/90-OR-Inhibition-of-miRNA-200b-Rescues-Diabetes"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-90-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"90-OR"},{"indexed":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T16:11:35Z","timestamp":1656346295289},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"19_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2014,10,1]]},"abstract":"Abstract<\/jats:title>\n Introduction: Neuroblastoma is the most common extracranial solid malignancy in early childhood. WDR5 is an essential component of the MLL and SET1\/COMPASS histone H3 lysine 4 (H3K4) methyltransferase complex and plays a key role in the trimethylation of H3K4. However, there is no previous study establishing the role of WDR5 in neuroblastoma.<\/jats:p>\n Results: Affymetrix gene array studies showed that knocking-down WDR5 expression with siRNAs reduced the expression of the cell cycle genes cyclin E1. Consistently, RT-PCR and immunoblot confirmed that WDR5 siRNAs reduced cyclin E1 mRNA and protein expression, ChIP assays showed that WDR5 siRNAs reduced histone H3K4 tri-methylation at the cyclin E1 gene promoter, and Alamar blue assays demonstrated that WDR5 induced neuroblastoma cell proliferation. Additionally, high levels of WDR5 gene expression in human neuroblastoma tissues predict poor patient survival independent of patient age and disease stage.<\/jats:p>\n Conclusions: Our data demonstrate WDR5 as a novel co-factor in neuroblastoma oncogenesis, and provide critical evidence to support the application of WDR5 inhibitors for the therapy of neuroblastoma patients.<\/jats:p>\n Citation Format: Yuting Sun, Pei Yan Liu, Daniel Carter, Nicolas Sokolowski, Karen L. MacKenzie, Glenn M. Marshall, Tao Liu. The histone methyltransferase adaptor WDR5 is a novel cofactor in neuroblastoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1378. doi:10.1158\/1538-7445.AM2014-1378<\/jats:p>","DOI":"10.1158\/1538-7445.am2014-1378","type":"journal-article","created":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T21:52:08Z","timestamp":1430517128000},"page":"1378-1378","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 1378: The histone methyltransferase adaptor WDR5 is a novel cofactor in neuroblastoma"],"prefix":"10.1158","volume":"74","author":[{"given":"Yuting","family":"Sun","sequence":"first","affiliation":[{"name":"Children's Cancer Institute Australia, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Children's Cancer Institute Australia, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Carter","sequence":"additional","affiliation":[{"name":"Children's Cancer Institute Australia, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Sokolowski","sequence":"additional","affiliation":[{"name":"Children's Cancer Institute Australia, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L.","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"Children's Cancer Institute Australia, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn M.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Children's Cancer Institute Australia, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Children's Cancer Institute Australia, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/74\/19_Supplement\/1378\/593261\/Abstract-1378-The-histone-methyltransferase","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/74\/19_Supplement\/1378\/593261\/Abstract-1378-The-histone-methyltransferase","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T15:43:02Z","timestamp":1656344582000},"score":7.656127,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/74\/19_Supplement\/1378\/593261\/Abstract-1378-The-histone-methyltransferase"}},"issued":{"date-parts":[[2014,10,1]]},"references-count":0,"journal-issue":{"issue":"19_Supplement","published-print":{"date-parts":[[2014,10,1]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2014-1378","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2014,10,1]]}},{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:53:35Z","timestamp":1787961215043,"version":"build-2784847793"},"reference-count":38,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Aspect"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Autism"],"published-print":{"date-parts":[[2025,8]]},"abstract":"Autistic people often encounter significant barriers when navigating airports, largely due to overwhelming sensory environments, stringent security procedures, and crowded spaces. This study aimed to enhance understanding of airport accessibility by retrospectively analyzing reports from Autistic-led environmental assessments conducted at six Australian airports between 2017 and 2024. Drawing on an evidence-informed autism-friendly framework, the assessments focused on eight key elements, including sensory adaptations, communication supports, and preparation and predictability. Through reflexive thematic analysis, two key themes were generated: (1) navigating the sensory landscape and (2) help passengers navigate with confidence. Our findings underscore the importance of sensory adjustments\u2014such as natural lighting and quiet spaces\u2014alongside clearer visual aids and communication supports. Importantly, this study represents the first systematic application of autism-friendly principles to airport environments, offering practical, evidence-based recommendations for more inclusive design. By foregrounding the perspectives of Autistic individuals, this research highlights the need for participatory design approaches to create public spaces that are genuinely accessible and supportive for Autistic travelers<\/jats:p>\n \n Lay abstract<\/jats:title>\n Airports can be challenging for Autistic people because of overwhelming sensory experiences like bright lights and loud noises, security processes, and crowded spaces. This study analyzed reports from six Australian airports, produced between 2017 and 2024, to understand how airports can be made better for Autistic travelers. These reports were based on assessments led by Autistic people and used a specific framework to evaluate areas like sensory experiences and communication needs. The study found two main ways to improve accessibility: (1) reducing sensory challenges, like loud noises or bright, overwhelming areas, and (2) improving communication and wayfinding to make navigation clearer and easier. Some of the recommendations included providing quiet spaces for travelers, using softer and more natural lighting, and improving signs to make it easier for people to navigate airports. This is the first study to apply autism-friendly principles to airports and shows the importance of involving Autistic people in the design of more inclusive public spaces. The findings offer practical recommendations for airports around the world to better support Autistic travelers.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/13623613251337200","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T04:45:10Z","timestamp":1746765910000},"page":"2151-2162","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Autistic-led insights on airport accessibility: A retrospective analysis of environmental assessments"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-674X","authenticated-orcid":false,"given":"Chris","family":"Edwards","sequence":"first","affiliation":[{"name":"Aspect (Autism Spectrum Australia), Australia"},{"name":"Griffith University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6647-9814","authenticated-orcid":false,"given":"Abigail MA","family":"Love","sequence":"additional","affiliation":[{"name":"Aspect (Autism Spectrum Australia), Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-0495","authenticated-orcid":false,"given":"Ru","family":"Ying Cai","sequence":"additional","affiliation":[{"name":"Aspect (Autism Spectrum Australia), Australia"},{"name":"La Trobe University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Tutton","sequence":"additional","affiliation":[{"name":"Aspect (Autism Spectrum Australia), Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Beardsley","sequence":"additional","affiliation":[{"name":"Aspect (Autism Spectrum Australia), Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-5164","authenticated-orcid":false,"given":"Vicki","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Aspect (Autism Spectrum Australia), Australia"},{"name":"The University of Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"crossref","unstructured":"Black M. H. McGarry S. Churchill L. D\u2019Arcy E. Dalgleish J. Nash I. Jones A. Tse T. Y. Gibson J. B\u00f6lte S. Girdler S. (2022). Considerations of the built environment for autistic individuals: A review of the literature. Autism 26(8) 1904\u20131915. https:\/\/doi.org\/10.1177\/13623613221102753","DOI":"10.1177\/13623613221102753"},{"key":"e_1_3_3_3_1","doi-asserted-by":"crossref","unstructured":"Brake J. (2024). \u201cMy struggles are largely sensory processing\u201d: The sensory world of autistic people. Journal of Human Behavior in the Social Environment 1\u201323. https:\/\/doi.org\/10.1080\/10911359.2024.2382108","DOI":"10.1080\/10911359.2024.2382108"},{"key":"e_1_3_3_4_1","doi-asserted-by":"crossref","unstructured":"Braun V. Clarke V. (2021). One size fits all? What counts as quality practice in (reflexive) thematic analysis? Qualitative Research in Psychology 18(3) 328\u2013352. https:\/\/doi.org\/10.1080\/14780887.2020.1769238","DOI":"10.1080\/14780887.2020.1769238"},{"key":"e_1_3_3_5_1","doi-asserted-by":"crossref","unstructured":"Braun V. Clarke V. Hayfield N. Terry G. (2019). Thematic analysis. In Liamputtong P. (Ed.) Handbook of research methods in health social sciences (pp. 843\u2013860). Springer. https:\/\/doi.org\/10.1007\/978-981-10-5251-4_103","DOI":"10.1007\/978-981-10-5251-4_103"},{"key":"e_1_3_3_6_1","author":"British Standards Institution","year":"2022","unstructured":"British Standards Institution. (2022). PAS 6463:2022 Design for the mind: Neurodiversity and the built environment.","journal-title":"PAS 6463:2022 Design for the mind: Neurodiversity and the built environment"},{"key":"e_1_3_3_7_1","unstructured":"Bureau of Infrastructure and Transport Research Economics. (2021). Domestic aviation activity: Cities and regions. 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Liu X. (2023). Family travel among people with autism: Challenges and support needs. 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The purpose of this study was to compare (non-inferiority) a new morphometric designed stem for total hip arthroplasty (THA) against an established comparator.<\/jats:p>A prospective randomised multi-centre study of 144 primary cementless THA performed by nine experienced orthopaedic surgeons was completed (70 received a fully coated collarless tapered stem and 74 received a morphometric designed proximally coated tapered stem). PROMs and blood serum markers were assessed preoperatively and at intervals up to 2-years postoperatively. In addition, measures of femoral stem fit, fill and subsidence at 2-years post-operatively were measured from radiographs by three observers, with an intra-class correlation coefficient of 0.918. A mixed effects model was employed to compare the two prosthesis over the study period. A p-value <0.05 was considered statistically significant.<\/jats:p>Demographics, Dorr types and blood serum markers were similar between groups. Both stems demonstrated a significant improvement in PROMs between the pre- and post-operative measurements, with no difference at any timepoint (p > 0.05). The fully coated tapered collarless femoral stem had a non-significantly higher intra-operative femoral fracture rate (5.8% vs 1.4%, p = 0.24), with all patients treated with cable fixation and partial weight bearing. The mean subsidence at 2-years was 2.5mm +\/\u2212 2.3mm for the morphometric stem and 2.4mm +\/\u2212 1.8mm for the fully coated tapered collarless femoral stem (p = 0.879). There was one outlier in each group with increased subsidence (fully coated tapered collarless femoral stem 6.9mm, morphometric wedge stem 7.4mm), with both patients reporting thigh pain at 2 years.<\/jats:p>When compared with an established stem, the newer designed morphometric wedge stem performed well with comparable radiological and PROM outcomes at 2 year follow up. Continued follow-up is required for long term benchmarking.<\/jats:p>","DOI":"10.1302\/1358-992x.2023.3.100","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T16:05:27Z","timestamp":1677168327000},"page":"100-100","update-policy":"http:\/\/dx.doi.org\/10.1302\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A PROSPECTIVE MULTICENTRE RANDOMIZED COMPARATIVE STUDY ASSESSING A NEW MORPHOMETRIC-DESIGNED STEM FOR TOTAL HIP ARTHROPLASTY: BENCHMARKING AGAINST AN ESTABLISHED COMPARATOR"],"prefix":"10.1302","volume":"105-B","author":[{"given":"T.","family":"Tran","sequence":"first","affiliation":[{"name":"Monash Health, Victoria, Australia. Fremantle Hospital, Western Australia, Australia. Rockingham General Hospital, Western Australia, Australia. Mater Health Services North Queensland, Queensland, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Driessen","sequence":"additional","affiliation":[{"name":"Monash Health, Victoria, Australia. Fremantle Hospital, Western Australia, Australia. Rockingham General Hospital, Western Australia, Australia. Mater Health Services North Queensland, Queensland, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Yap","sequence":"additional","affiliation":[{"name":"Monash Health, Victoria, Australia. Fremantle Hospital, Western Australia, Australia. Rockingham General Hospital, Western Australia, Australia. Mater Health Services North Queensland, Queensland, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.J.","family":"Ng","sequence":"additional","affiliation":[{"name":"Monash Health, Victoria, Australia. Fremantle Hospital, Western Australia, Australia. Rockingham General Hospital, Western Australia, Australia. Mater Health Services North Queensland, Queensland, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Khorshid","sequence":"additional","affiliation":[{"name":"Monash Health, Victoria, Australia. Fremantle Hospital, Western Australia, Australia. Rockingham General Hospital, Western Australia, Australia. Mater Health Services North Queensland, Queensland, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Wall","sequence":"additional","affiliation":[{"name":"Monash Health, Victoria, Australia. Fremantle Hospital, Western Australia, Australia. Rockingham General Hospital, Western Australia, Australia. Mater Health Services North Queensland, Queensland, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Yates","sequence":"additional","affiliation":[{"name":"Monash Health, Victoria, Australia. Fremantle Hospital, Western Australia, Australia. Rockingham General Hospital, Western Australia, Australia. Mater Health Services North Queensland, Queensland, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Prosser","sequence":"additional","affiliation":[{"name":"Monash Health, Victoria, Australia. Fremantle Hospital, Western Australia, Australia. Rockingham General Hospital, Western Australia, Australia. Mater Health Services North Queensland, Queensland, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Monash Health, Victoria, Australia. Fremantle Hospital, Western Australia, Australia. Rockingham General Hospital, Western Australia, Australia. Mater Health Services North Queensland, Queensland, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hazratwala","sequence":"additional","affiliation":[{"name":"Monash Health, Victoria, Australia. Fremantle Hospital, Western Australia, Australia. Rockingham General Hospital, Western Australia, Australia. Mater Health Services North Queensland, Queensland, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"42","container-title":["Orthopaedic Proceedings"],"language":"en","link":[{"URL":"https:\/\/boneandjoint.org.uk\/doi\/10.1302\/1358-992X.2023.3.100\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/boneandjoint.org.uk\/doi\/10.1302\/1358-992X.2023.3.100\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/boneandjoint.org.uk\/doi\/pdf\/10.1302\/1358-992X.2023.3.100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T16:05:28Z","timestamp":1677168328000},"score":7.655738,"resource":{"primary":{"URL":"https:\/\/boneandjoint.org.uk\/doi\/10.1302\/1358-992X.2023.3.100"}},"issued":{"date-parts":[[2023,2]]},"references-count":0,"journal-issue":{"issue":"SUPP_3","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1302\/1358-992X.2023.3.100"],"URL":"https:\/\/doi.org\/10.1302\/1358-992x.2023.3.100","ISSN":["1358-992X","2049-4416"],"issn-type":[{"value":"1358-992X","type":"print"},{"value":"2049-4416","type":"electronic"}],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"2023-2-","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T21:50:03Z","timestamp":1770241803171,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The HearCog trial was designed to evaluate the impact of hearing aid intervention on patients with age\u2010related hearing loss and cognitive impairment. An imaging substudy, utilising\n 18<\/jats:sup>\n F\u2010FDG PET\/CT as a functional imaging modality, was embedded to evaluate patterns of metabolic activity following early hearing aid intervention (group A) or delayed hearing aid intervention (group B).\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n 28 study participants (mean age=77.4 years) underwent brain\n 18<\/jats:sup>\n F\u2010FDG PET\/CT imaging at baseline and 12 months, with\n n<\/jats:italic>\n \u00a0=\u00a014 from each group. All imaging was undertaken using the same PET\/CT camera (Biograph 64 mCT, Siemens Healthineers) accredited for quantitative assessment by the Australasian Radiopharmaceutical Trials Network. The\n 18<\/jats:sup>\n F\u2010FDG dose was 185 MBq with a 10\u2010minute acquisition starting after 45 minutes uptake. For analysis of regional variation of\n 18<\/jats:sup>\n F\u2010FDG brain metabolism, we employed the Molecular Imaging Neurology Database Comparison software application (Syngo.via MI Neurology DB Comparison, Siemens Healthineers) where\n 18<\/jats:sup>\n F\u2010FDG brain scans from age\u2010matched (range 49\u201079 years,\n n<\/jats:italic>\n \u00a0=\u00a033) healthy volunteers were available for comparison. The analyses included semi\u2010automated anatomical co\u2010registration of subject images to the reference database, followed by an automated anatomical labelling of brain regions using the integrated atlas from Montreal Neurological Institute (MNI, McGill University). We compared the differences between the groups and the normal database for both timepoints, and performed parametric and non\u2010parametric statistical testing on differences between the study groups.\n <\/jats:p>\n <\/jats:sec>\n \n Result<\/jats:title>\n \n There were no significant differences between the groups in age, gender, injected\n 18<\/jats:sup>\n F\u2010FDG activity, uptake time or days between imaging timepoints (\n p<\/jats:italic>\n \u00a0\u22650.06). Database analysis identified 5 regions associated with increased\n 18<\/jats:sup>\n F\u2010FDG uptake between baseline and 12 months in the early (group A) compared to late (group B) intervention cohort. These regions include the central region (left and right), left central region, right rolandic operculum, left paracentral lobule and the left precentral gyrus.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Analysis using standardised regions from Neurology Database comparison software demonstrates relative improvements in the motor\/sensorimotor areas of the brain in the early compared to late intervention group. Further analysis will be undertaken integrating MRI and PET data for improved anatomical delineation in particular for evaluation of cognitive and auditory regions of the brain.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz70856_100129","type":"journal-article","created":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T12:24:19Z","timestamp":1766665459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HearCog Trial\u2010 Findings from FDG\u2010PET"],"prefix":"10.1002","volume":"21","author":[{"given":"Heidi","family":"Espedal","sequence":"first","affiliation":[{"name":"The University of Western Australia, Western Australia National Imaging Facility, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dona M P","family":"Jayakody","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Ear Science Institute Australia, Subiaco, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Polpo","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ford H","family":"Andrew","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Flicker","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Royal Perth Hospital, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo P","family":"Almeida","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roslyn","family":"Francis","sequence":"additional","affiliation":[{"name":"Harry Perkins Institute of Medical Research, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,25]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz70856_100129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz70856_100129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T09:07:01Z","timestamp":1770196021000},"score":7.655595,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz70856_100129"}},"issued":{"date-parts":[[2025,12]]},"references-count":0,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/alz70856_100129"],"URL":"https:\/\/doi.org\/10.1002\/alz70856_100129","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-12-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e100129"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:27Z","timestamp":1753890027403,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Exosomes are small nanovesicles that carry bioactive molecules (e.g., miRNAs) which can be delivered to other cells and modify their phenotype. Recently, we have established that the number of circulating exosomes is higher in women with gestational diabetes mellitus (GDM); however, the exosomal miRNA profile in GDM across gestation has not been established yet. The aim of this study was to establish the circulating exosomal miRNA profile in women with normal glucose tolerance (NGT) and GDM women (BMI-matched) in a prospective cohort of patients at three time points during pregnancy. Exosomal RNA was sequenced using an Illumina NextSeq 500 platform. Linear mixed modelling was performed on the normalized miRNAs across gestation for normal and GDM pregnancies, using the lme4 package in R. Statistically significant differences in miRNA expression between NGT and GDM women was determined using likelihood ratio tests. In the first trimester of pregnancy, 92% (84 out of 92) of exosomal miRNAs were significantly elevated in plasma of women with GDM when compared to NGT women. Interestingly, in the second trimester of pregnancy the expression of these miRNA decreased in the GDM women with no significance difference observed in the exosomal miRNA profile between GDM and NGT women. Gene ontology analysis revealed that miRNAs which changed expression across gestation for GDM pregnancies are involved in the regulation of insulin.<\/jats:p>\n In summary, we have identified a range of exosomal miRNAs which change expression across gestation for GDM and normal pregnancies. Gene ontology analysis revealed that these miRNAs are involved in the regulation of insulin, playing significant role in the pathophysiology of GDM.<\/jats:p>\n \n Disclosure<\/jats:title>\n D. Guanzon: None. A. Lai: None. K. Scholz-Romero: None. F. Zu\u00f1iga: None. E. Diaz: None. H. McIntyre: Speaker's Bureau; Self; Novo Nordisk Inc.. Research Support; Self; Danish Diabetes Academy. M. Lappas: None. C. Salomon: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-166-lb","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:32Z","timestamp":1529693852000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["Circulating Exosomal miRNA Signature in Pregnancies with Gestational Diabetes Mellitus across Gestation"],"prefix":"10.2337","volume":"67","author":[{"given":"DOMINIC","family":"GUANZON","sequence":"first","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREW","family":"LAI","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATHERIN","family":"SCHOLZ-ROMERO","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FELIPE","family":"ZU\u00d1IGA","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EMILIO","family":"DIAZ","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"DAVID MCINTYRE","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTHA","family":"LAPPAS","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARLOS","family":"SALOMON","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Concepci\u00f3n, Chile, South Brisbane, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/166-LB\/54306\/Circulating-Exosomal-miRNA-Signature-in","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/166-LB\/54306\/Circulating-Exosomal-miRNA-Signature-in","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T22:58:22Z","timestamp":1652741902000},"score":7.653931,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/166-LB\/54306\/Circulating-Exosomal-miRNA-Signature-in"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-166-lb","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"166-LB"},{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:26:53Z","timestamp":1787246813862,"version":"build-2736575974"},"reference-count":0,"publisher":"Society of Exploration Geophysicists","content-domain":{"domain":[],"crossmark-restriction":false},"abstract":"We describe a workflow that combines petrographic, petrophysical, geomechanical and rock physics data to predict the 4D seismic response of a carbonate reservoir. Fifty standard 38mm dia x 60 mm long core plugs were provided from eight lithofacies in an Albian age carbonate reservoir in offshore Brazil. A disc 6-8 mm thick was cut from each plug end, polished on both sides and used for imaging and electrical-dielectric measurements. A mini-core from selected discs was used for x-ray micro-CT. Electron microscopy, helium porosity\/permeability and nuclear magnetic resonance (NMR) were used to identify the lithotypes and textural characteristics of grains and pores in the rock. Medical x-ray CT was used to assess the degree of heterogeneity of each plug, screen for vugs, fractures or core damage that could affect rock properties. Eight peloidal packstone samples from the top reservoir were used for mechanical studies, and subjected to UCS, isotropic compaction, single stage triaxial tests or zero later strain stress-path tests to define the Mohr-Coulomb failure envelope and pore collapse pressure for this lithofacies both brine saturated and dry. Samples representative of the peloidal packstones, grainstones, and oncolitic floatstones were subjected to a range of stress-path rock physics measurements, again either dry or brine saturated to define the stress sensitivity. Saturation sensitivity of Vp for 5 samples was assessed during brine flooding experiments monitored by x-ray CT. Low frequency seismic response (1-100 Hz) was measured on 5 samples under dry and brine saturated conditions. Mechanical and rock physics data show that the majority of lithofacies are strongly water weakening and seismic velocities reduced substantially in the presence of brine to values much below that predicted by Gassmann substitution. In 4 of the low frequency samples, the shear modulus became indeterminate after brine saturation. Digital rock models were useful to assess permeability and mechanical upscaling laws, but estimates of velocities from digital rock models, even when calibrated with nano-indentation, were inaccurate owing to unresolved microstructure, and water weakening. Complex pore structures led to poor discrimination of pore size distributions from NMR, but dielectric models based on the Hanai-Bruggeman theory could be used to assess pore aspect ratio. High frequency electrical measurements correlate strongly with both porosity and with seismic velocities.<\/jats:p>","DOI":"10.1190\/ice2015-2195280","type":"proceedings-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T14:10:38Z","timestamp":1458223838000},"page":"495-495","source":"Crossref","is-referenced-by-count":0,"title":["Multiphysics Characterization of an Albian Post-Salt Carbonate Reservoir, Brazil"],"prefix":"10.1190","volume":"1","author":[{"given":"Michael B.","family":"Clennell*","sequence":"additional","affiliation":[{"name":"(1) CSIRO, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Mueller","sequence":"additional","affiliation":[{"name":"(1) CSIRO, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeriya","family":"Shulakova","sequence":"additional","affiliation":[{"name":"(1) CSIRO, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"(2) University of Western Australia, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassili","family":"Mikhaltsevitch","sequence":"additional","affiliation":[{"name":"(3) Curtin University, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Esteban","sequence":"additional","affiliation":[{"name":"(1) CSIRO, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Sarout","sequence":"additional","affiliation":[{"name":"(1) CSIRO, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Gurevich","sequence":"additional","affiliation":[{"name":"(3) Curtin University, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Delle Piane","sequence":"additional","affiliation":[{"name":"(1) CSIRO, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Josh","sequence":"additional","affiliation":[{"name":"(1) CSIRO, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim","family":"Lebedev","sequence":"additional","affiliation":[{"name":"(3) Curtin University, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Correia-Lopes","sequence":"additional","affiliation":[{"name":"(3) Curtin University, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iko","family":"Burgar","sequence":"additional","affiliation":[{"name":"(4) RMIT University, Melbourne, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Pervukhina","sequence":"additional","affiliation":[{"name":"(1) CSIRO, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremie","family":"Dautriat","sequence":"additional","affiliation":[{"name":"(1) CSIRO, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Falcao","sequence":"additional","affiliation":[{"name":"(5) CENPES, Petrobras, Rio de Janeiro, Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"186","published-online":{"date-parts":[[2015,9,16]]},"event":{"name":"International Conference and Exhibition, Melbourne, Australia 13-16 September 2015","location":"Melbourne, Australia","acronym":"icemelbourne2015","start":{"date-parts":[[2015,9,13]]},"end":{"date-parts":[[2015,9,16]]}},"container-title":["Global Meeting Abstracts","International Conference and Exhibition, Melbourne, Australia 13-16 September 2015"],"link":[{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/495\/714293","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/495\/714293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:45:11Z","timestamp":1787244311000},"score":7.653734,"resource":{"primary":{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/495\/714293"}},"issued":{"date-parts":[[2015,9,16]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1190\/ice2015-2195280","ISSN":["2159-6832"],"issn-type":[{"value":"2159-6832","type":"electronic"}],"published":{"date-parts":[[2015,9,16]]}},{"indexed":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T01:30:28Z","timestamp":1649208628612},"reference-count":0,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"15_suppl","funder":[{"name":"None"}],"content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2021,5,20]]},"abstract":" e18685 <\/jats:p> Background: Health systems pressures during the COVID-19 pandemic have driven adoption of innovative models of cancer care which optimise resources and protect patients and staff. High-value changes should be identified and retained to improve resilience of cancer care. Methods: Cancer Australia reviewed the literature and consulted with oncology health professionals, cancer control experts and consumers to examine elements of cancer care that changed during the pandemic. Strategies that support high-value care and improve cancer outcomes were identified. Results: The pandemic highlighted models of care which minimise risk of infection for cancer patients, whilst optimising outcomes. Of the numerous cancer care elements that we examined, this abstract focuses on key enhancements in digital health and treatment practices. Digital health helped maintain quality and continuity of cancer care during the pandemic. Use of telehealth (for clinical and supportive care), e-prescribing, and e-ordering of investigations increased, supported by national health system funding. Shared care between care settings was facilitated by rapid uptake of telehealth, e-health records, virtual multidisciplinary team meetings and secure messaging. Treatment modifications included hypofractionated radiotherapy, transitioning to oral chemotherapy where possible, and home-based palliative care. Lower thresholds adopted for use of G-CSF with chemotherapy to reduce risk of febrile neutropenia, aimed to decrease hospital admission rates. It is important to address barriers to uptake of these high value changes. For digital health, variations in patient access to telehealth and digital health literacy can be reduced through technical and coordination support (tailored to people with diverse needs and backgrounds), with telehealth consultations offered in safe, accessible clinical or community settings. Administrative and technical burdens in health service settings can be mitigated through sustainable IT infrastructure, standardised processes for appointments, and improving staff digital health capabilities. Patient anxiety regarding changes in care plans can be mitigated through transparent, accessible, and culturally appropriate communication, documentation and shared decision-making. Clinician uncertainty in calculating risks and benefits in treatment modifications can be addressed through evidence-based standardised care procedures and risk-stratification protocols. Conclusions: Many modifications to cancer care made during the pandemic can have long-term benefits and should become standard care, including enhancements in digital health and treatment practices. Strategies have been identified which enable these changes and address barriers to uptake at the system-, service-, practitioner-, and patient-level. Efforts to embed high value changes are required across the cancer control sector. <\/jats:p>","DOI":"10.1200\/jco.2021.39.15_suppl.e18685","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T14:28:38Z","timestamp":1622644118000},"page":"e18685-e18685","update-policy":"http:\/\/dx.doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["COVID-19 and cancer care: Embedding high-value changes into practice."],"prefix":"10.1200","volume":"39","author":[{"given":"Vivienne","family":"Milch","sequence":"first","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Der Vartanian","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Austen","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhona","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candice-Brooke","family":"Woods","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillian","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen P.","family":"Ackland","sequence":"additional","affiliation":[{"name":"Calvary Mater Newcastle Hospital, Newcastle, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleola","family":"Anderiesz","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy Mary Kate","family":"Keefe","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","container-title":["Journal of Clinical Oncology"],"language":"en","deposited":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T14:55:50Z","timestamp":1622645750000},"score":7.6534176,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2021.39.15_suppl.e18685"}},"issued":{"date-parts":[[2021,5,20]]},"references-count":0,"journal-issue":{"issue":"15_suppl","published-print":{"date-parts":[[2021,5,20]]}},"alternative-id":["10.1200\/JCO.2021.39.15_suppl.e18685"],"URL":"https:\/\/doi.org\/10.1200\/jco.2021.39.15_suppl.e18685","ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"published":{"date-parts":[[2021,5,20]]},"assertion":[{"value":"2021-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:22:24Z","timestamp":1787242944511,"version":"build-2736575974"},"reference-count":43,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Discourse Studies"],"published-print":{"date-parts":[[2018,10]]},"abstract":"This article examines emergency ambulance calls made by lay callers for patients found to be in cardiac arrest when the paramedics arrived. Using conversation analysis, we explored the trajectories of calls in which the caller, before being asked by the call-taker, said why they were calling, that is, calls in which callers pre-empted a reason-for-the-call. Caller pre-emption can be disruptive when call-takers first need to obtain an address and telephone number. Pre-emptions have further implications when call-takers reach the stage when they are required to deliver the scripted turn \u2018 tell me exactly what happened\u2019. When there has been a pre-emption earlier on, callers tend to treat the scripted turn as a request for more information and may not repeat their reason-for-the-call. This can occasion delays and important information can be lost. We identified an effective alternative strategy used by some call-takers, pre-emption repeat, which callers treat as a request for confirmation.<\/jats:p>","DOI":"10.1177\/1461445618754435","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T01:21:22Z","timestamp":1519780882000},"page":"666-687","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Hijacking the dispatch protocol: When callers pre-empt their reason-for-the-call in emergency calls about cardiac arrest"],"prefix":"10.1177","volume":"20","author":[{"given":"Marine","family":"Riou","sequence":"first","affiliation":[{"name":"Curtin University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Ball","sequence":"additional","affiliation":[{"name":"Curtin University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay 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The NeoCombi study is a pilot phase II study of neoadjuvant dabrafenib plus trametinib in patients with resectable Stage IIIB-C BRAFV600 mutation positive melanoma. Patients receive 12 weeks of combined drug treatment, followed by surgical resection of all disease. Patients then continue combination drug treatment for a further 40 weeks. We aimed to identify host and tumour biomarkers that predict response to MAPK inhibition.<\/jats:p>\n Blood and tumour samples were obtained at baseline, early during treatment (3-7 days on therapy), at completion resection after 12 weeks on therapy, and, if relevant, on progression. Additional blood samples were also collected every 2 weeks up to 12 weeks of therapy. Samples were processed to generate plasma, peripheral blood mononuclear cells (PBMCs), fresh frozen tumour and where possible, tumour-dissociates and cell lines (tumour and immune cells). We have profiled tumour-specific and peripheral immune responses using a combination of flow cytometry, mass cytometry and multiplex cytokine\/chemokine arrays. We also profiled circulating tumour-associated DNA (ctDNA) in plasma.<\/jats:p>\n To date, we have accrued 17 patients onto the NeoCombi study. Primary analysis of the first 12 patients has been completed. Decreases in ctDNA and tumour viability, in addition to immunophenotype changes, were seen within 1 week of starting treatment. Changes in immunophenotype continued throughout the first 12 weeks of treatment with conversion of CD8+ and CD4+ naive (CD45RA+) cells to effector cells (CD45RA-) in most patients. We also noted that activation of regulatory T cells (CD4+CD25+CD127-HLA-DR+) increased over the first 12 weeks of treatment in patients with partial pathological responses compared to those with complete pathological responses. Interestingly, the cytokine profile remained relatively stable across treatment within each patient, suggesting that factors already present at baseline may determine response to treatment. A pro-inflammatory cytokine signature has been identified as a potential biomarker of patients likely to relapse and in vitro validation studies are currently underway. Additionally, although ctDNA was only detectable in 42% of patients (compared to over 70% in patients with stage IV disease), high levels of ctDNA identified patients at highest risk of relapse and, if detectable, proved a useful marker to monitor treatment response.<\/jats:p>\n In conclusion, we have identified both host and tumour-specific biomarkers which may be useful to predict (and to monitor) response to MAPK inhibition in melanoma patients.<\/jats:p>\n Citation Format: Sarah J. Welsh, Suzanah Boyd, Helen McGuire, Maria Gonzales, Alexander M. Menzies, Hojabr Kakavand, Elisa James, Elizabeth Smith, Barbara Fazekas, Richard F. Kefford, Alex Guminski, Richard A. Scolyer, Georgina V. Long, Helen Rizos. In depth immune profiling of the response of melanoma to MAPK inhibition. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. 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A handbook for activists","author":"Noble J.","year":"2006"},{"key":"bibr28-10778012231196051","doi-asserted-by":"publisher","DOI":"10.1080\/1354570022000077926"},{"key":"bibr29-10778012231196051","doi-asserted-by":"publisher","DOI":"10.1080\/14649880500120509"},{"key":"bibr30-10778012231196051","doi-asserted-by":"publisher","DOI":"10.4159\/harvard.9780674061200"},{"key":"bibr100-10778012231196051","unstructured":"Okin S. M. (1991). Gender, the public and the private. In: D. Held (ed.),\n Political theory today\n . Stanford University Press."},{"key":"bibr31-10778012231196051","doi-asserted-by":"publisher","DOI":"10.4135\/9781849208888"},{"key":"bibr32-10778012231196051","volume-title":"Blush: faces of shame","author":"Probyn E.","year":"2005"},{"key":"bibr33-10778012231196051","volume-title":"Narrative methods for the human sciences","author":"Riessman C. 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M.","year":"2007","journal-title":"Brigham Young University Law Review"}],"container-title":["Violence Against Women"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10778012231196051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10778012231196051","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10778012231196051","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10778012231196051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:56:44Z","timestamp":1777687004000},"score":7.6531816,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10778012231196051"}},"issued":{"date-parts":[[2023,8,23]]},"references-count":40,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1177\/10778012231196051"],"URL":"https:\/\/doi.org\/10.1177\/10778012231196051","ISSN":["1077-8012","1552-8448"],"issn-type":[{"value":"1077-8012","type":"print"},{"value":"1552-8448","type":"electronic"}],"published":{"date-parts":[[2023,8,23]]}},{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:51:08Z","timestamp":1782730268725,"version":"3.54.5"},"reference-count":30,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"unspecified","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022217","name":"Flinders Foundation","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100022217","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,10,29]]},"published-print":{"date-parts":[[2024,11]]},"abstract":"\n Background<\/jats:title>\n Protecting doctors\u2019 mental health has typically focused on individuals, rather than addressing organisational and structural-level factors in the work environment.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n This study uses the socioecological model (SEM) to illuminate and explore how these broader factors inform the mental health of individual doctors.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Semi-structured interviews (20\u201325\u2009hours) and ethnographic observations (90 hours) involving work shadowing doctors (n=14).<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Doctors representing various career stages, specialty areas, genders and cultural backgrounds.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Three specialties in a public South Australian hospital. Thematic analysis revealed work-related risk factors for poor mental health.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The SEM framework was used to analyse the work environment\u2019s impact on doctors\u2019 mental health. The analysis identified how the layers interconnect to influence risk factors for individual doctors.\n Microsystem<\/jats:italic>\n : lack of control over career advancement, disenfranchisement due to understaffing and concerns about handling complex cases relative to experience.\n Mesosystem<\/jats:italic>\n : negative impacts of shift work and fragmented teams, leading doctors to absorb pressure despite exhaustion to maintain professional credibility.\n Exosystem<\/jats:italic>\n : high patient loads with time constraints and geographical limitations hindering care delivery, compounded by administrative burdens.\n Macrosystem<\/jats:italic>\n : the commercialisation of medicine emphasising corporatisation and bureaucratic processes, which devalues professional autonomy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study highlights how doctors experience layers of interconnected factors that compromise their mental health but over which they have very little control. Interventions must therefore address these issues at organisational and systemic levels, for which starting points evident within our data are identified.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-088283","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T10:55:54Z","timestamp":1732013754000},"page":"e088283","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Work-related impacts on doctors\u2019 mental health: a qualitative study exploring organisational and systems-level risk factors"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9103-0445","authenticated-orcid":false,"given":"Belinda","family":"Lunnay","sequence":"first","affiliation":[{"name":"Torrens University Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Foley","sequence":"additional","affiliation":[{"name":"Torrens University Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5464-8887","authenticated-orcid":false,"given":"Sharon","family":"Lawn","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8815-3009","authenticated-orcid":false,"given":"Michael","family":"Baigent","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Weightman","sequence":"additional","affiliation":[{"name":"SA Health, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Lawrence","sequence":"additional","affiliation":[{"name":"SA Health, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Drummond","sequence":"additional","affiliation":[{"name":"Torrens University Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandi","family":"Baker","sequence":"additional","affiliation":[{"name":"University of Waterloo, Waterloo, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-9714","authenticated-orcid":false,"given":"Paul R","family":"Ward","sequence":"additional","affiliation":[{"name":"Torrens University Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"2025121510350856000_14.11.e088283.1","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1097\/JOM.0000000000002505","article-title":"Differential impacts of the COVID-19 pandemic on mental health symptoms and working conditions for senior and junior doctors in Australian hospitals","volume":"64","author":"Pascoe","year":"2022","journal-title":"J Occup Environ Med"},{"key":"2025121510350856000_14.11.e088283.2","unstructured":"Lawrence D , Wu F , Ireland M , et al . National mental health survey of doctors and medical students. Beyond Blue, 2013."},{"key":"2025121510350856000_14.11.e088283.3","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/imj.13717","article-title":"Depression and suicide among medical practitioners in Australia","volume":"48","author":"Bailey","year":"2018","journal-title":"Intern Med J"},{"key":"2025121510350856000_14.11.e088283.4","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1177\/00048674221106677","article-title":"The comparative mental health of Australian doctors before and during COVID-19: A population-based approach","volume":"57","author":"Hoang","year":"2023","journal-title":"Aust N Z J Psychiatry"},{"key":"2025121510350856000_14.11.e088283.5","unstructured":"Wu F , Ireland M , Hafekost K , et al . National mental health survey of doctors and medical students. Australia: Beyond Blue, 2013."},{"key":"2025121510350856000_14.11.e088283.6","doi-asserted-by":"crossref","first-page":"471","DOI":"10.5694\/mja17.00891","article-title":"Burnout in the medical profession: not a rite of passage","volume":"208","author":"Baigent","year":"2018","journal-title":"Med J Aust"},{"key":"2025121510350856000_14.11.e088283.7","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/S0140-6736(21)01596-8","article-title":"Mental illness and suicide among physicians","volume":"398","author":"Harvey","year":"2021","journal-title":"The Lancet"},{"key":"2025121510350856000_14.11.e088283.8","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19053079","article-title":"The workplace and psychosocial experiences of Australian senior doctors during the COVID-19 pandemic: A qualitative study","volume":"19","author":"Tran","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"2025121510350856000_14.11.e088283.9","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18179263","article-title":"Occupational disruptions during the COVID-19 pandemic and their association with healthcare workers\u2019 mental health","volume":"18","author":"Smallwood","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"2025121510350856000_14.11.e088283.10","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/imj.15720","article-title":"The workplace and psychosocial experiences of Australian junior doctors during the COVID-19 pandemic","volume":"52","author":"Hunter","year":"2022","journal-title":"Intern Med J"},{"key":"2025121510350856000_14.11.e088283.11","doi-asserted-by":"crossref","unstructured":"Bronfenbrenner U . Recent advances in research on the ecology of human development. In: Development as action in context: problem behavior and normal youth development. 1986: 287\u2013309.","DOI":"10.1007\/978-3-662-02475-1_15"},{"key":"2025121510350856000_14.11.e088283.12","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.32.7.513"},{"key":"2025121510350856000_14.11.e088283.13","doi-asserted-by":"publisher","DOI":"10.1177\/104973239800800305"},{"key":"2025121510350856000_14.11.e088283.14","doi-asserted-by":"publisher","DOI":"10.1177\/1468794105056923"},{"key":"2025121510350856000_14.11.e088283.15","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1177\/10497323211015966","article-title":"Observation and institutional ethnography: helping us to see better","volume":"31","author":"Balcom","year":"2021","journal-title":"Qual Health Res"},{"key":"2025121510350856000_14.11.e088283.16","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/soc4.12155","article-title":"How to use social theory within and throughout qualitative research in healthcare contexts","volume":"8","author":"Meyer","year":"2014","journal-title":"Sociol Compass"},{"key":"2025121510350856000_14.11.e088283.17","unstructured":"Liamputtong P , Ezzy D . Qualitative Research Methods. Melbourne: Oxford University Press, 2005."},{"key":"2025121510350856000_14.11.e088283.18","unstructured":"Miles MB , Huberman AM . Qualitative Data Analysis: an expanded sourcebook. Sage, London, 1994."},{"key":"2025121510350856000_14.11.e088283.19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-13-1"},{"key":"2025121510350856000_14.11.e088283.20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00011363-199205000-00003","article-title":"Ethnography and research: a qualitative view","volume":"12","author":"Patton","year":"1992","journal-title":"Top Lang Disord"},{"key":"2025121510350856000_14.11.e088283.21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.5153\/sro.2819","article-title":"The application of abductive and retroductive inference for the design and analysis of theory-driven sociological research","volume":"18","author":"Meyer","year":"2013","journal-title":"Sociol Res Online"},{"key":"2025121510350856000_14.11.e088283.22","doi-asserted-by":"crossref","first-page":"586","DOI":"10.4300\/JGME-D-17-00557.1","article-title":"Damned if you do, damned if you don\u2019t: bias in evaluations of female resident physicians","volume":"9","author":"Choo","year":"2017","journal-title":"J Grad Med Educ"},{"key":"2025121510350856000_14.11.e088283.23","doi-asserted-by":"publisher","DOI":"10.1177\/1090198115575098"},{"key":"2025121510350856000_14.11.e088283.24","doi-asserted-by":"crossref","first-page":"116471","DOI":"10.1016\/j.socscimed.2023.116471","article-title":"Beyond burnout: Moral suffering among healthcare workers in the first COVID-19 surge","volume":"340","author":"Sherman","year":"2024","journal-title":"Soc Sci Med"},{"key":"2025121510350856000_14.11.e088283.25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/teo0000161","article-title":"Understanding moral injury from a character domain perspective","volume":"41","author":"Atuel","year":"2021","journal-title":"J Theor Philos Psychol"},{"key":"2025121510350856000_14.11.e088283.26","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1177\/09697330231164762","article-title":"Examining moral injury in clinical practice: A narrative literature review","volume":"30","author":"Mewborn","year":"2023","journal-title":"Nurs Ethics"},{"key":"2025121510350856000_14.11.e088283.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2004.03.004"},{"key":"2025121510350856000_14.11.e088283.28","first-page":"273","article-title":"Gender differences in the application of communication skills, emotional labor, stress-coping and well-being among physicians","volume":"2","author":"Lovell","year":"2009","journal-title":"Archives Int J Med"},{"key":"2025121510350856000_14.11.e088283.29","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1751-9020.2007.00084.x","article-title":"Emotional labor and health care","volume":"2","author":"Erickson","year":"2008","journal-title":"Sociol Compass"},{"key":"2025121510350856000_14.11.e088283.30","doi-asserted-by":"publisher","DOI":"10.1080\/13648470802121844"}],"container-title":["BMJ Open"],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2024-088283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T18:35:17Z","timestamp":1765823717000},"score":7.6519294,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2024-088283"}},"issued":{"date-parts":[[2024,11]]},"references-count":30,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11,19]]},"published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1136\/bmjopen-2024-088283"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2024-088283","ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"published":{"date-parts":[[2024,11]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:24Z","timestamp":1753889844299,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Cytokines that signal through the JAK-STAT pathway, such as interferon-\u03b3 (IFN-\u03b3) and common \u03b3 chain cytokines, play an important role in facilitating the destruction of insulin-secreting \u03b2 cells by CD8+ T cells in type 1 diabetes. We previously showed that inhibiting JAK1\/JAK2 reversed autoimmune insulitis in non-obese diabetic (NOD) mice and also blocked IFN-\u03b3 mediated MHC class I upregulation on \u03b2 cells. Blocking interferons on their own did not prevent diabetes in knockout NOD mice, so we tested whether JAK inhibitor action on signaling downstream of common \u03b3 chain family cytokines, including IL-2, IL-21, IL-7 and IL-15, may also affect progression of diabetes in NOD mice. Common \u03b3 chain cytokines activate JAK1 and JAK3 to regulate T cell proliferation. We compared JAK1-selective inhibitors with our previous data with JAK1\/JAK2 inhibition. JAK1-selective inhibitors reduced IL-21, IL-2 and IL-7 signaling in T cells (p&lt;0.05) and IFN-\u03b3 signaling in \u03b2 cells, but did not affect GM-CSF signaling in granulocytes. When given in vivo to NOD mice, JAK1-selective inhibitors reduced CD8+ T cell proliferation (Ki-67) in islets, reduced immune cell infiltration into islets and prevented MHC class I upregulation on \u03b2 cells as measured by flow cytometry. Newly diagnosed diabetes was reversed in 94% NOD mice treated twice daily with JAK1-selective inhibitors.<\/jats:p>\n Our results indicate that JAK inhibitors block common \u03b3 chain cytokines in lymphocytes and interferons in lymphocytes and \u03b2 cells and are thus more effective against diabetes pathogenesis than IFN\u03b3 receptor deficiency alone. Our studies pave the way for use of this class of drug in clinical trials for type 1 diabetes.<\/jats:p>\n \n Disclosure<\/jats:title>\n G. Jhala: None. T. Ge: None. B. Krishnamurthy: None. T. Kay: None. H.E. Thomas: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n National Health and Medical Research Council of Australia (GNT1145507); JDRF (1-SRA-2018-599-S-B)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-289-or","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:49Z","timestamp":1592238589000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["289-OR: JAK Inhibitors Block Interferon and Common Gamma Chain Cytokine Signaling to Reverse Diabetes in NOD Mice"],"prefix":"10.2337","volume":"69","author":[{"given":"GAURANG","family":"JHALA","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TINGTING","family":"GE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BALASUBRAMANIAN","family":"KRISHNAMURTHY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"THOMAS","family":"KAY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HELEN E.","family":"THOMAS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/289-OR\/56794\/289-OR-JAK-Inhibitors-Block-Interferon-and-Common","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/289-OR\/56794\/289-OR-JAK-Inhibitors-Block-Interferon-and-Common","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:49:38Z","timestamp":1647164978000},"score":7.651893,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/289-OR\/56794\/289-OR-JAK-Inhibitors-Block-Interferon-and-Common"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-289-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"289-OR"},{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:27:29Z","timestamp":1782876449732,"version":"3.54.5"},"reference-count":59,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T00:00:00Z","timestamp":1349308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Health Educ Behav"],"published-print":{"date-parts":[[2013,8]]},"abstract":"\n Background<\/jats:italic>\n . Internationally, over the last four decades large-scale mass media campaigns have been delivered to promote physical activity and its associated health benefits. In 2002-2005, the first Western Australian statewide adult physical activity campaign\n Find Thirty. It\u2019s Not a Big Exercise<\/jats:italic>\n was launched. In 2007, a new iteration of the campaign was proposed with new objectives, executions, and tag line\n \n Find Thirty every day\n \u00ae<\/jats:sup>\n . Purpose\n <\/jats:italic>\n . This article reports on the population-level effects of the\n Find Thirty every day<\/jats:italic>\n \u00ae<\/jats:sup>\n campaign from 2008 to 2010, with a focus on changes in awareness, intention, and physical activity.\n Methods<\/jats:italic>\n . Evaluation of the campaign involved pre- and posttest serial cross-sectional surveys. Baseline data were collected in May 2008, and subsequent surveys in 2009 and 2010. Samples sizes were as follows: baseline (\n n<\/jats:italic>\n = 972), first follow-up (\n n<\/jats:italic>\n = 938), and second follow-up (\n n<\/jats:italic>\n = 937). Data were derived from self-reported responses to a random-sample computer-assisted telephone interview.\n Results<\/jats:italic>\n . Total awareness increased from 30.4% at baseline to 48.5% at second follow-up. Total awareness was higher in women and low socioeconomic status adults. Intention was 21.0%, double that reported at baseline. There were positive significant changes from baseline to first follow-up across all four categories: walking, moderate, vigorous, and total physical activity. There also were positive significant changes for self-reported walking from baseline to second follow-up.\n Conclusion. Find Thirty every day<\/jats:italic>\n \u00ae<\/jats:sup>\n resulted in an increase in awareness, intention, walking, vigorous intensity, and total level of physical activity in priority target groups. Campaign effects should be further examined by subgroups to identify the most receptive population segments.\n <\/jats:p>","DOI":"10.1177\/1090198112459515","type":"journal-article","created":{"date-parts":[[2012,10,6]],"date-time":"2012-10-06T00:24:54Z","timestamp":1349483094000},"page":"480-492","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of Find Thirty every day\n \u00ae<\/sup>"],"prefix":"10.1177","volume":"40","author":[{"given":"Justine E.","family":"Leavy","sequence":"first","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian E.","family":"Bauman","sequence":"additional","affiliation":[{"name":"University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona C.","family":"Bull","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billie","family":"Giles-Corti","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Shilton","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"},{"name":"Heart Foundation (WA Division), Subiaco, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clover","family":"Maitland","sequence":"additional","affiliation":[{"name":"Heart Foundation (WA Division), Subiaco, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanne","family":"Barnes","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,10,4]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.29.020907.090824"},{"key":"e_1_3_2_3_1","volume-title":"Physical activity patterns of Australian adults. 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Interrogation of these tests may present opportunities for healthcare savings.<\/jats:p><\/jats:sec>Methods<\/jats:title>This multicentre retrospective study over a 2.5\u2010year period examined the frequency with which three common endocrinological investigations [thyroid stimulating hormone (TSH), HbA1c, 25\u2010hydroxy Vitamin D3] were performed in this population, including the frequency of duplicate tests within a given admission, and the frequency of abnormal test results. The Medicare Benefits Schedule was used to calculate the cost associated with these tests.<\/jats:p><\/jats:sec>Results<\/jats:title>There were 28,564 individual admissions included in the study. Individuals \u226565\u2009years old were the majority of inpatients in whom the selected tests were performed (80% of tests). TSH was performed in 6730 admissions, HbA1c was performed in 2259 admissions, and vitamin D levels were performed in 5632 admissions. There were 6114 vitamin D tests performed during the study period, of which 2911 (48%) returned outside the normal range. The cost associated with vitamin D level testing was $183,726. Over the study period, 8% of tests for TSH, HbA1c, and Vitamin D were duplicates (where a second test was performed within a single admission), which was associated with a cost of $32,134.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Tests for common endocrinological abnormalities are associated with significant healthcare costs. 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Accessed December 18 2022.www.nice.org.uk\/guidance\/ph56"}],"container-title":["Australasian Journal on Ageing"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajag.13226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T04:35:22Z","timestamp":1758083722000},"score":7.6512794,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajag.13226"}},"issued":{"date-parts":[[2023,7,11]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/ajag.13226"],"URL":"https:\/\/doi.org\/10.1111\/ajag.13226","archive":["Portico"],"ISSN":["1440-6381","1741-6612"],"issn-type":[{"type":"print","value":"1440-6381"},{"type":"electronic","value":"1741-6612"}],"published":{"date-parts":[[2023,7,11]]},"assertion":[{"value":"2023-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T20:06:45Z","timestamp":1769112405789,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024253","name":"Western Australian Future Health and Innovation Fund, Government of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012155","name":"Channel 7 Telethon Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Skin concerns are frequent among urban\u2010living Aboriginal children, yet specialist dermatology consultations are limited with studies highlighting the need for improved cultural security. Through newly established paediatric dermatology clinics at two urban Aboriginal Community Controlled Health Organisations (ACCHOs), we aimed to describe clinic and patient data, including disease frequencies and associations, to inform dermatology service provision and advocacy.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective cohort study of Aboriginal children and young people (CYP, 0\u201318\u2009years) attending Aboriginal Health Practitioner (AHP) co\u2010ordinated paediatric dermatology clinics at two urban ACCHOs.<\/jats:p><\/jats:sec>Results<\/jats:title>Data were collected from 32 clinics over 19 months, with 335 episodes of care and a mean attendance rate of 74%. From 78 new patients, 72 (92%) were recruited into the study, only one of whom had previously received dermatologist assessment. Eczema, tinea or acne accounted for 47% (34\/72) of referrals, and 60% of patients received their first appointment within 4\u2009weeks of referral. In 47\/72 (65%) consultations, the GP referral and dermatologist diagnosis concurred. The most frequent diagnoses (primary or secondary) at first consultation were atopic dermatitis (26%, 19\/72), dermatophyte infections (25%, 18\/72), acne (21%, 15\/72), bacterial skin infections (18%, 13\/72) and post\u2010inflammatory dyspigmentation (18%, 13\/72). Three categories of the 2022 Australasian College of Dermatologists curriculum (infections, eczema\/dermatitis, pigmentary disorders) accounted for 59% of all diagnoses.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This study highlights the specialist dermatology needs of urban\u2010living Aboriginal CYP. ACCHO\u2010embedded dermatology clinics co\u2010ordinated by AHPs demonstrated benefits for Aboriginal CYP in accessing care. Opportunities to embed dermatology practice within ACCHOs should be prioritised.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.14363","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T06:54:56Z","timestamp":1724914496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Skin health of Aboriginal children living in urban communities"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5902-040X","authenticated-orcid":false,"given":"Bernadette M.","family":"Ricciardo","sequence":"first","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute Nedlands Western Australia Australia"},{"name":"Perth Children's Hospital Nedlands Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather\u2010Lynn","family":"Kessaris","sequence":"additional","affiliation":[{"name":"Perth Children's Hospital Nedlands Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Telethon Kids Institute Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel","family":"Nannup","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"Telethon Kids Institute Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Tilbrook","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute Nedlands Western Australia Australia"},{"name":"Maalingup Aboriginal Gallery Caversham Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Rind","sequence":"additional","affiliation":[{"name":"Derbarl Yerrigan Health Service Aboriginal Corporation East Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richelle","family":"Douglas","sequence":"additional","affiliation":[{"name":"Derbarl Yerrigan Health Service Aboriginal Corporation East Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodie","family":"Ingrey","sequence":"additional","affiliation":[{"name":"South West Aboriginal Medical Service Bunbury Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacinta","family":"Walton","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Michie","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad","family":"Farrant","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"Telethon Kids Institute Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloise","family":"Delaney","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Prasad","family":"Kumarasinghe","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"Western Dermatology Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R.","family":"Carapetis","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute Nedlands Western Australia Australia"},{"name":"Perth Children's Hospital Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asha C.","family":"Bowen","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute Nedlands Western Australia Australia"},{"name":"Perth Children's Hospital Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14222"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326\u20105377.2010.tb03833.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.31128\/AJGP-03-24-7177"},{"key":"e_1_2_11_5_1","volume-title":"Commissioner for Children and Young People: Profile of Children and Young People in 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Housing","year":"2023"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100625.2001.100102.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.12.020"},{"key":"e_1_2_11_15_1","unstructured":"The Australasian College of Dermatologists.AusDerm training program curriculum (version 1.1).2022."},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13500"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12273"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1071\/AH21363"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12939\u2010021\u201001443\u20100"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.52114"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(20)32149\u20108"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010019\u20104750\u20105"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18063014"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2009.tb02570.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20100960.2007.00340.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136789"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/s2040174418000661"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15122827"},{"key":"e_1_2_11_29_1","first-page":"387","article-title":"Common dermatologic disorders in skin of color: a comparative practice survey","volume":"80","author":"Alexis AF","year":"2007","journal-title":"Cutis"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2009.04.001"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/ccid.s158129"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.13263"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15726"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12556"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.03.053"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17608"},{"key":"e_1_2_11_37_1","volume-title":"National Healthy Skin Guideline: for the diagnosis, treatment and prevention of skin infections for aboriginal and Torres Strait islander children and communities in Australia","author":"The Australian Healthy Skin Consortium","year":"2023"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20103102"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13570"}],"container-title":["Australasian Journal of Dermatology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.14363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T12:23:02Z","timestamp":1736770982000},"score":7.6510534,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.14363"}},"issued":{"date-parts":[[2024,8,28]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/ajd.14363"],"URL":"https:\/\/doi.org\/10.1111\/ajd.14363","archive":["Portico"],"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"published":{"date-parts":[[2024,8,28]]},"assertion":[{"value":"2024-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:23Z","timestamp":1753890023558,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Background: Both increased blood pressure variability (BPV) and lack of nocturnal blood pressure dipping (NBPD) are independently associated with excess mortality in patients with diabetes mellitus. We hypothesised that patients with diabetes and CKD have higher BPV and are more likely to demonstrate a lack of nocturnal blood pressure dipping, than their counterparts without CKD.<\/jats:p>\n Methods: Clinical and biochemical data were collected from 124 patients attending diabetes clinics at Austin Health, Melbourne Australia. Stage 3 to 5 CKD (from here on referred to as \u201cCKD\u201d) was defined by a CKD-EPI eGFR of &lt;60ml\/min\/1.73m2. Patients underwent 24h ambulatory blood pressure monitoring within one year either side of the eGFR measurement. BPV was calculated using standard deviation (SD) and coefficient of variation (SD\/mean*100). Night-to-day systolic BP ratio of&gt;90% suggested abnormal NBPD (\u201cnon dippers\u201d).<\/jats:p>\n Results: Thirty-four patients (27%) had CKD. The mean\u00b1SD 24h systolic blood pressure was higher in patients with CKD than those without (135\u00b116mmHg vs. 129\u00b113mmHg respectively, p=0.03), and there was a negative correlation between eGFR and 24h systolic BP (r = -0.21, p=0.02). No association was found between eGFR and BPV. A negative correlation was found between eGFR and night-to-day systolic BP ratio, whereby lower eGFR was associated with higher night-to-day systolic BP ratio (i.e., with lack of NBPD). This relationship remained significant after adjusting for age and sex.<\/jats:p>\n Conclusion: Amongst patients with diabetes, reduced eGFR was associated with higher blood pressure and abnormal NBPD, but not with BPV. Further study is needed to characterise blood pressure fluctuations in diabetic patients with CKD, who constitute a high risk group.<\/jats:p>\n \n Disclosure<\/jats:title>\n R. Libianto: None. S. Baqar: None. T.D. Vu: None. R. MacIsaac: None. E.I. Ekinci: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-2179-pub","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:33Z","timestamp":1529693853000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Blood Pressure Variability and Nocturnal Dipping in Diabetic Patients With and Without Chronic Kidney Disease"],"prefix":"10.2337","volume":"67","author":[{"given":"RENATA","family":"LIBIANTO","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Heidelberg West, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SARA","family":"BAQAR","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Heidelberg West, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"THUY D.","family":"VU","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Heidelberg West, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"MACISAAC","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Heidelberg West, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIF I.","family":"EKINCI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Heidelberg West, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/2179-PUB\/55806\/Blood-Pressure-Variability-and-Nocturnal-Dipping","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/2179-PUB\/55806\/Blood-Pressure-Variability-and-Nocturnal-Dipping","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:38:16Z","timestamp":1647164296000},"score":7.6510463,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/2179-PUB\/55806\/Blood-Pressure-Variability-and-Nocturnal-Dipping"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-2179-pub","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"2179-PUB"},{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T06:49:48Z","timestamp":1774075788671,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2017,2,1]]},"DOI":"10.1164\/rccm.201607-1366le","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T23:42:20Z","timestamp":1657842140000},"page":"398-401","source":"Crossref","is-referenced-by-count":3,"title":["Noninvasive Assessment of Cardiopulmonary Reserve: Toward Early Detection of Pulmonary Vascular Disease"],"prefix":"10.1093","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1949-1359","authenticated-orcid":false,"given":"Timothy J.","family":"Baillie","sequence":"first","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"},{"name":"University of Adelaide, Adelaide, South Australia, Australia, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Sidharta","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"},{"name":"University of Adelaide, Adelaide, South Australia, Australia, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Steele","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen G.","family":"Worthley","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"},{"name":"University of Adelaide, Adelaide, South Australia, Australia, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Willoughby","sequence":"additional","affiliation":[{"name":"South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Teo","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashanthan","family":"Sanders","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"},{"name":"University of Adelaide, Adelaide, South Australia, Australia, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"},{"name":"University of Adelaide, Adelaide, South Australia, Australia, and"},{"name":"South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew I.","family":"Worthley","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"},{"name":"University of Adelaide, Adelaide, South Australia, Australia, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,2,1]]},"reference":[{"key":"2026032023362167200_bib1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"2015 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT)","volume":"37","author":"Gali\u00e8","year":"2016","journal-title":"Eur Heart J"},{"key":"2026032023362167200_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","article-title":"The meaning and use of the area under a receiver operating characteristic (ROC) curve","volume":"143","author":"Hanley","year":"1982","journal-title":"Radiology"},{"key":"2026032023362167200_bib3","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1161\/01.CIR.82.5.1595","article-title":"Effects of adenosine on human coronary arterial circulation","volume":"82","author":"Wilson","year":"1990","journal-title":"Circulation"},{"key":"2026032023362167200_bib4","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.amjcard.2012.02.026","article-title":"Usefulness of intravenous adenosine in idiopathic pulmonary arterial hypertension as a screening agent for identifying long-term responders 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Positive outcomes can include feelings of acceptance and support, but negative outcomes can include stigma and discrimination. Although a surge in research on this topic has led to more understanding around autism disclosure, the methodologies used may have limited who was contributing to the conversation and data. To overcome this, we analyzed 3 years (2020\u22122022) of social media data (Reddit and Twitter) as this was public information that did not rely on researcher data collection. Reflexive thematic analysis of 3121 posts led to the generation of four themes: People do not understand autism (with experiences related to employment, dating, healthcare and mental health), autistic people just want privacy and respect, autistic people can lead us forward and non-autistic people need to assume more responsibility. We discuss how autistic adults experience the impact of society\u2019s lack of understanding of autism on a daily basis whether they disclose or not, and that it is everybody\u2019s responsibility to challenge negative stereotypes and promote a more inclusive society.<\/jats:p>\n \n Lay abstract<\/jats:title>\n Autism disclosure \u2013 that is sharing their autism diagnosis or identity with a person or people \u2013 is a difficult decision for many autistic people. While telling people they are autistic can be positive and helpful, it can also create a lot of problems. What we have learnt is that disclosure is really complicated. Rather than asking research participants questions about what might happen, we looked at what people were saying on public social media posts (Reddit and Twitter) about what did happen. We used three years of posts that were related to autism disclosure from a wide range of adults (autistic and non-autistic). Four main ideas were created from our data, with the key finding being that society does not understand autism. This lack of understanding creates problems for autistic people in work, dating, healthcare and mental health. The remaining ideas were that autistic people should have privacy and be treated with respect, that autistic representation can help society and that non-autistic people need to do more to help autistic people. Our findings support that society needs to do more through autism advocacy, better media representation and more public role models. Increasing the accuracy of understanding of autism across society will mean that autistic people can feel safer to disclose if they want to.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/13623613231192133","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T07:44:16Z","timestamp":1692690256000},"page":"1107-1119","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["\u2018Most people have no idea what autism is\u2019: Unpacking autism disclosure using social media analysis"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-674X","authenticated-orcid":false,"given":"Chris","family":"Edwards","sequence":"first","affiliation":[{"name":"Autism Spectrum Australia, Australia"},{"name":"Griffith University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6647-9814","authenticated-orcid":false,"given":"Abigail M A","family":"Love","sequence":"additional","affiliation":[{"name":"Autism Spectrum Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0258-3348","authenticated-orcid":false,"given":"Sandra C","family":"Jones","sequence":"additional","affiliation":[{"name":"Australian Catholic University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-0495","authenticated-orcid":false,"given":"Ru Ying","family":"Cai","sequence":"additional","affiliation":[{"name":"Autism Spectrum Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyd Thai Hoang","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Queensland University of Technology, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-5164","authenticated-orcid":false,"given":"Vicki","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Autism Spectrum Australia, Australia"},{"name":"University of Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"bibr1-13623613231192133","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20043246"},{"key":"bibr2-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1609\/icwsm.v14i1.7347"},{"key":"bibr3-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1080\/09687599.2020.1822782"},{"key":"bibr4-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1177\/2156869318804297"},{"key":"bibr5-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"bibr6-13623613231192133","volume-title":"Successful qualitative research: A practical guide for beginners","author":"Braun V.","year":"2013"},{"key":"bibr7-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1080\/2159676X.2019.1628806"},{"key":"bibr8-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1057\/9781137337016_8"},{"key":"bibr9-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-018-03878-x"},{"key":"bibr10-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1089\/aut.2020.0016"},{"key":"bibr11-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-015-2535-1"},{"key":"bibr12-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2021.102080"},{"key":"bibr13-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1007\/s40489-021-00263-w"},{"key":"bibr14-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-020-04486-4"},{"key":"bibr15-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1177\/13623613221145377"},{"key":"bibr16-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-8437-0_3"},{"key":"bibr17-13623613231192133","volume-title":"Participatory and inclusive autism research practice guides","author":"den Houting J.","year":"2021"},{"key":"bibr18-13623613231192133","unstructured":"Dixon S. (2022a). Average monthly users (MAU) of Reddit from April 2018 to January 2020. Statistica. https:\/\/www.statista.com\/statistics\/1324258\/reddit-monthly-active-users\/"},{"key":"bibr19-13623613231192133","unstructured":"Dixon S. (2022b). Number of Twitter users worldwide from 2019 to 2024. Statistica. https:\/\/www.statista.com\/statistics\/303681\/twitter-users-worldwide\/"},{"key":"bibr20-13623613231192133","doi-asserted-by":"publisher","DOI":"10.26522\/ssj.v16i2.2675"},{"key":"bibr21-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2022.101936"},{"key":"bibr22-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1177\/13623613231153480"},{"key":"bibr23-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1108\/AIA-02-2021-0014"},{"key":"bibr24-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1177\/13623613211041006"},{"key":"bibr25-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1352\/1934-9556-52.6.456"},{"key":"bibr26-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2652"},{"key":"bibr27-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1177\/0894439318788322"},{"key":"bibr28-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1089\/aut.2021.0016"},{"key":"bibr29-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1080\/10510974.2013.855642"},{"key":"bibr30-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-021-05384-z"},{"key":"bibr31-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-017-3166-5"},{"key":"bibr32-13623613231192133","unstructured":"Jamnik M. 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(2022). Neurodiversity is not just for those we work with: A group of psychologists write. The Psychologist, 35, 2\u20135. https:\/\/www.bps.org.uk\/psychologist\/neurodiversity-not-just-those-we-work"},{"key":"bibr43-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1089\/aut.2022.0073"},{"key":"bibr44-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1177\/20563051211019004"},{"key":"bibr45-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1089\/aut.2020.0063"},{"key":"bibr46-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1177\/23969415211022955"},{"key":"bibr47-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1089\/aut.2020.0031"},{"key":"bibr48-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1038\/srep40700"},{"key":"bibr49-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1016\/j.intmar.2020.05.001"},{"key":"bibr50-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1080\/10911350902790720"},{"key":"bibr51-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1177\/15394492221103850"},{"key":"bibr52-13623613231192133","doi-asserted-by":"publisher","DOI":"10.31128\/AJGP-03-21-1234e"},{"key":"bibr53-13623613231192133","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2020.101598"}],"container-title":["Autism"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13623613231192133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13623613231192133","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13623613231192133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:51:23Z","timestamp":1777380683000},"score":7.650515,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13623613231192133"}},"issued":{"date-parts":[[2023,8,22]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1177\/13623613231192133"],"URL":"https:\/\/doi.org\/10.1177\/13623613231192133","ISSN":["1362-3613","1461-7005"],"issn-type":[{"value":"1362-3613","type":"print"},{"value":"1461-7005","type":"electronic"}],"published":{"date-parts":[[2023,8,22]]}},{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:33:04Z","timestamp":1770755584122,"version":"3.50.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2024,9]]},"abstract":"Abstract<\/jats:title>\u2018Ramping\u2019 is a commonly used term in contemporary Australian healthcare. It is also a part of the public and political zeitgeist. However, its precise definition varies among sources. In the published literature, there are distinctions between related terms, such as \u2018entry overload\u2019 and \u2018Patient Off Stretcher Time Delay\u2019. How ramping is defined and how it came to be defined have significance for policies and procedures relating to the described phenomenon. Through examination of the history of the term, insights are obtained into the underlying issues contributing to ramping and, accordingly, associated possible solutions.<\/jats:p>","DOI":"10.1111\/imj.16466","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T06:32:41Z","timestamp":1722493961000},"page":"1577-1580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A brief history of ramping"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1993-213X","authenticated-orcid":false,"given":"Benjamin","family":"Cook","sequence":"first","affiliation":[{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"},{"name":"SA Health Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Northern Adelaide Local Health Network Adelaide South Australia 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aenj.2017.07.002"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2700.43201"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.20.5.406"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10903120590962102"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aenj.2010.02.004"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(03)00747-9"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10903127.2011.561412"},{"key":"e_1_2_2_9_1","first-page":"69","volume-title":"An Exploratory Study to Examine the Phenomenon and Practice of Ambulance Ramping at Hospitals within the Queensland Health Southern Districts and the Queensland Ambulance Service","author":"Hammond E","year":"2011"},{"key":"e_1_2_2_10_1","unstructured":"Australian Medical Association.2023 Ambulance Ramping Report Card; 2023."},{"key":"e_1_2_2_11_1","first-page":"334","volume-title":"Annual Report, 2021\u201322","author":"NSW Health","year":"2022"},{"key":"e_1_2_2_12_1","unstructured":"Queensland Health.Protocol for Timely Transfer of Care in Emergency Departments [Updated 2021 Oct 1]. Available from URL:https:\/\/www.health.qld.gov.au\/system-governance\/policies-standards\/health-service-directives\/patient-access-to-care\/protocol-for-timely-transfer-of-care-in-emergency-departments."},{"key":"#cr-split#-e_1_2_2_13_1.1","unstructured":"SA Health.Ambulance Waiting Times [Updated 2024 Feb 9"},{"key":"#cr-split#-e_1_2_2_13_1.2","unstructured":"Cited 2024 Feb 10]. Available from URL:https:\/\/www.sahealth.sa.gov.au\/wps\/wcm\/connect\/public+content\/sa+health+internet\/about+us\/our+performance\/ambulance+waiting+times."},{"key":"e_1_2_2_14_1","first-page":"344","volume-title":"Annual Report 2021\u201022","author":"Tasmanian Government Department of Health","year":"2022"},{"key":"e_1_2_2_15_1","first-page":"152","volume-title":"Annual Report, 2021\u201322","author":"Ambulance Victoria","year":"2022"},{"key":"#cr-split#-e_1_2_2_16_1.1","unstructured":"St Johns Ambulance Western Australia.Ambulance Activity and Response Times [Updated 2024 Feb 16"},{"key":"#cr-split#-e_1_2_2_16_1.2","unstructured":"Cited 2024 Feb 16]. Available from URL:https:\/\/stjohnwa.com.au\/ambulance-and-health-services\/metro-ambulance-service\/ambulance-activity-and-response-times."},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/10903120600725884"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2012-202258"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.51613"},{"key":"e_1_2_2_20_1","first-page":"58","volume-title":"Public Hospitals: Cycle of Crisis","author":"Australian Medical Association","year":"2021"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2009.tb02451.x"},{"key":"e_1_2_2_22_1","first-page":"7","volume-title":"Position Statement on Access Block","author":"Australasian College for Emergency Medicine","year":"2022"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jen.2022.03.001"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2003.302"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203316"},{"key":"e_1_2_2_26_1","first-page":"52","volume-title":"Metropolitan Emergency Department Access Initiative: A Report on Ambulance Ramping in Metropolitan Hospitals","author":"Queensland Health","year":"2012"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2014.1462"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ienj.2016.12.005"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/01605682.2020.1753955"},{"key":"e_1_2_2_30_1","first-page":"7","volume-title":"Fit to Sit Pathways","author":"SA Health","year":"2023"}],"container-title":["Internal Medicine Journal"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.16466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T13:03:45Z","timestamp":1725627825000},"score":7.6504054,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.16466"}},"issued":{"date-parts":[[2024,7,31]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/imj.16466"],"URL":"https:\/\/doi.org\/10.1111\/imj.16466","archive":["Portico"],"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"published":{"date-parts":[[2024,7,31]]},"assertion":[{"value":"2024-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T05:33:06Z","timestamp":1766467986562,"version":"build-2065373602"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T00:00:00Z","timestamp":1452211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health Workforce Australia"}],"content-domain":{"domain":["asmepublications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Clinical Teacher"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Residential aged care environments can provide valuable learning opportunities for health professional education. An aged care community\u2013university partnership developed the Beyond the Teaching Nursing Home: Community Partnership of Learning and Care (\n BTTNH<\/jats:styled-content>\n :\u00a0\n CPLC<\/jats:styled-content>\n ) programme, where older adults volunteer in learning activities with health professional students. This article describes medical students\u2019 experience of participating in a clinical learning activity as part of the broader programme.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n Fourth\u2010year medical students (enrolled in a 6\u2013year medical degree) on geriatric medicine rotation participated in a half\u2010day clinical visit as part of the\n BTTNH<\/jats:styled-content>\n :\u00a0\n CPLC<\/jats:styled-content>\n programme. Medical students participated in an interview activity with an older adult from the aged care facility. A survey was administered to evaluate medical students\u2019 experience of the structured clinical visit to a residential aged care facility.\n <\/jats:p>\n \n \n Residential aged care environments can provide valuable learning opportunities for health professional education<\/jats:p>\n <\/jats:disp-quote>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Medical students valued the learning experience of interacting with older adults, observation of the residential aged care environment and learning about the needs of older adults living in residential aged care.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Providing meaningful learning opportunities for medical students in residential aged care environments may contribute to a better understanding of residents, aged care environments, development of communication skills, professional role and clinical decision\u2010making skills that are relevant for the care of older adults not only in aged care but also in other care settings.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tct.12484","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T13:12:22Z","timestamp":1452431542000},"page":"100-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Demystifying aged care for medical students"],"prefix":"10.1111","volume":"14","author":[{"given":"Rosemary","family":"Saunders","sequence":"first","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Miller","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Dugmore","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Etherton\u2010Beer","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACM.0b013e3182557445"},{"volume-title":"Australian hospital statistics 2011\u201312","year":"2013","author":"Australian Institute of Health and Welfare","key":"e_1_2_7_3_1"},{"volume-title":"Movement between hospital and residential aged care 2008\u201309","year":"2013","author":"Australian Institute of Health and Welfare","key":"e_1_2_7_4_1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001888-200308000-00009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/02701960.2010.503128"},{"key":"e_1_2_7_7_1","unstructured":"BarnettK.Exploring the Teaching Nursing Home Model: Literature Review to Inform the National Evaluation of the TRACS Program Adelaide: Australian Workplace Innovation and Social Research Centre The University of Adelaide.2014. Available athttps:\/\/www.adelaide.edu.au\/wiser\/tracs\/publications\/docs\/TRACS-litrev-update2014.pdf. Accessed on 10 January 2014."},{"key":"e_1_2_7_8_1","unstructured":"EastonS.Future doctors learn from aged care. Australian Ageing Agenda 7\u00a0April\u00a02007. Available at:http:\/\/www.australianageingagenda.com.au\/2011\/04\/07\/future-doctors-learn-from-aged-care. Accessed on 10 January 2014."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/03601270903534630"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2006.05.009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-8610(04)70453-3"}],"container-title":["The Clinical Teacher"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftct.12484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftct.12484","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/asmepublications.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tct.12484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T17:15:08Z","timestamp":1762362908000},"score":7.650383,"resource":{"primary":{"URL":"https:\/\/asmepublications.onlinelibrary.wiley.com\/doi\/10.1111\/tct.12484"}},"issued":{"date-parts":[[2016,1,8]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/tct.12484"],"URL":"https:\/\/doi.org\/10.1111\/tct.12484","archive":["Portico"],"ISSN":["1743-4971","1743-498X"],"issn-type":[{"type":"print","value":"1743-4971"},{"type":"electronic","value":"1743-498X"}],"published":{"date-parts":[[2016,1,8]]},"assertion":[{"value":"2016-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:41:56Z","timestamp":1753890116108,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: Identifying risk of diabetes complications at diabetes onset is vital to a precision medicine approach to managing diabetes. A genetic risk score (GRS) could do this decades before positive biochemical tests. Therefore, we developed a novel GRS for predicting diabetic kidney disease (DKD), assessed its performance and analyzed clinical differences between genetic risk groups.<\/jats:p>\n Methods: The GRS was developed with data from &gt;2000 subjects. Its performance was tested on 429 adults with type 1 or type 2 diabetes attending a tertiary hospital. Cases were those with eGFR &lt;30 mL\/min. Controls had diabetes for &gt;10 years and eGFR &gt;60 mL\/min. Clinical differences between GRS groups were tested with sample t-test, Fisher\u2019s exact or Chi2 test, as appropriate.<\/jats:p>\n Results: People with a high GRS had an OR of 9.40 for developing DKD (95% CI 5.78-17.57, p&lt;0.0001). Those with low GRS and DKD were more likely to have a history of smoking, dyslipidaemia, hypertension, and other diabetes complications. Those with high GRS and DKD were also more likely to have other diabetes complications including cardiovascular disease. This group developed DKD more rapidly than those with low GRS and DKD. There were no statistically significant differences in HbA1c, BMI and duration of diabetes between those with and without DKD, in either risk group. A lower HbA1c throughout follow up did not affect progression to DKD.<\/jats:p>\n Conclusion: The GRS performed well in identifying risk of DKD. It also identified those with high risk of other diabetes complications.<\/jats:p>\n \n Disclosure<\/jats:title>\n A. Ali: None. K. Kishore: None. S. Golub: None. G. Morahan: Stock\/Shareholder; Advanced Genetic Diagnostics. E.I. Ekinci: Research Support; Amgen Inc, Novo Nordisk, Lilly Diabetes, AstraZeneca, Endogenex, Versanis. Advisory Panel; Lilly Diabetes, Novo Nordisk.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Diabetes Australia Research Grant (Y22G-ALIA)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-400-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:16:36Z","timestamp":1749791796000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["400-P: A Novel Genetic Risk Score Can Identify People at Risk of Diabetes Complications"],"prefix":"10.2337","volume":"74","author":[{"given":"ALEENA","family":"ALI","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KARTIK","family":"KISHORE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUZANNE","family":"GOLUB","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GRANT","family":"MORAHAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIF I.","family":"EKINCI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/400-P\/158630\/400-P-A-Novel-Genetic-Risk-Score-Can-Identify","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/400-P\/158630\/400-P-A-Novel-Genetic-Risk-Score-Can-Identify","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T15:46:14Z","timestamp":1750434374000},"score":7.649544,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/400-P\/158630\/400-P-A-Novel-Genetic-Risk-Score-Can-Identify"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-400-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"400-P"},{"indexed":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T05:15:41Z","timestamp":1678511741506},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Supplement 4","content-domain":{"domain":["www.auajournals.org"],"crossmark-restriction":true},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1097\/01.ju.0000557272.74213.01","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T05:40:57Z","timestamp":1556084457000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["MP74-18\u2003PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) TO BETTER CHARACTERISE INTRAPROSTATIC TUMOUR BURDEN: REVIEW OF AN ACADEMIC, TERTIARY CENTER SERIES"],"prefix":"10.1097","volume":"201","author":[{"given":"Matthew","family":"Roberts*","sequence":"first","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Donato","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Morton","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Kyle","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"Coughlin","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Esler","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel","family":"Dunglison","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Gardiner","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Yaxley","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"http:\/\/www.auajournals.org\/doi\/pdf\/10.1097\/01.JU.0000557272.74213.01","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T16:50:16Z","timestamp":1678467016000},"score":7.6494694,"resource":{"primary":{"URL":"http:\/\/www.auajournals.org\/doi\/10.1097\/01.JU.0000557272.74213.01"}},"issued":{"date-parts":[[2019,4]]},"references-count":0,"journal-issue":{"issue":"Supplement 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Cutoff"],"prefix":"10.1109","author":[{"given":"Andy","family":"Hu","sequence":"first","affiliation":[{"name":"Commonwealth Bank of Australia,Sydney,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devika","family":"Prasad","sequence":"additional","affiliation":[{"name":"Commonwealth Bank of Australia,Perth,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz","family":"Pizzato","sequence":"additional","affiliation":[{"name":"Commonwealth Bank of Australia,Sydney,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Foord","sequence":"additional","affiliation":[{"name":"Commonwealth Bank of Australia,Adelaide,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Abrahamyan","sequence":"additional","affiliation":[{"name":"Commonwealth Bank of Australia,Sydney,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Leontjeva","sequence":"additional","affiliation":[{"name":"Commonwealth Bank of Australia,Sydney,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cooper","family":"Doyle","sequence":"additional","affiliation":[{"name":"Commonwealth Bank of Australia,Sydney,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Jermyn","sequence":"additional","affiliation":[{"name":"Commonwealth Bank of Australia,Sydney,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/springerreference_179018"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1145\/3136625"},{"key":"ref3","first-page":"1877","article-title":"Language models are few-shot learners","volume":"33","author":"Brown","year":"2020","journal-title":"in Advances in Neural Information Processing Systems"},{"key":"ref4","article-title":"On the opportunities and risks of foundation models","volume-title":"arXiv preprint","author":"Bommasani","year":"2021"},{"key":"ref5","article-title":"Google\u2019s neural machine translation system: Bridging the gap between human and machine translation","volume-title":"arXiv preprint","author":"Wu","year":"2016"},{"key":"ref6","article-title":"Feature selection: A data perspective","volume-title":"CoRR","volume":"abs\/1601.07996","author":"Li","year":"2016"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2478\/cait-2019-0001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.7753\/IJCATR0506.1013"},{"key":"ref9","first-page":"329","article-title":"Feature selection methods: Case of filter and wrapper approaches for maximising classification accuracy","volume":"26","author":"Ibrahim","year":"2018","journal-title":"Pertanika Journal of Science and Technology"},{"key":"ref10","first-page":"1","article-title":"A hybrid genetic algorithm with wrapper-embedded approaches for feature selection","volume":"PP","author":"Liang","year":"2018","journal-title":"IEEE Access"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"101661","DOI":"10.1016\/j.swevo.2024.101661","article-title":"Evolutionary computation for feature selection in classification: A comprehensive survey of solutions, applications and challenges","volume":"90","author":"Song","year":"2024","journal-title":"Swarm and Evolutionary Computation"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0303088"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-55849-3_33"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","DOI":"10.3390\/pr11020562","article-title":"Hybrid filter and genetic algorithm-based feature selection for improving cancer classification in high-dimensional microarray data","volume":"11","author":"Ali","year":"2023","journal-title":"Processes"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1142\/s0219649220400195"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202705"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1109\/ems.2014.44"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.aci.2018.04.001"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","DOI":"10.3390\/a14030100","article-title":"A feature selection algorithm performance metric for comparative analysis","volume":"14","author":"Mostert","year":"2021","journal-title":"Algorithms"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jare.2023.01.014","article-title":"Hierarchical harris hawks optimizer for feature selection","volume":"53","author":"Peng","year":"2023","journal-title":"Journal of Advanced Research"},{"key":"ref21","volume-title":"Bayesian Optimization: Open source constrained global optimization tool for Python","author":"Nogueira","year":"2014"},{"key":"ref22","volume-title":"Golden-section search","author":"Dubail","year":"2022"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-2543-5_42"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1515\/jisys-2019-0062"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.eswa.2020.113389"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00500-020-05183-1"},{"issue":"4","key":"ref27","first-page":"1234","article-title":"Feature selection using the sine cosine algorithm","volume":"35","author":"Smith","year":"2021","journal-title":"Journal of Computational Intelligence"},{"key":"ref28","volume-title":"Airline Dataset - kaggle.com","author":"S","year":"2025"},{"key":"ref29","volume-title":"News Articles - kaggle.com","author":"ASADMAHMOOD","year":"2025"},{"key":"ref30","article-title":"BlogFeedback","author":"Buza","year":"2014","journal-title":"UCI Machine Learning Repository"},{"key":"ref31","first-page":"3687","article-title":"CARER: Contextualized affect representations for emotion recognition","volume-title":"Proceedings of the 2018 Conference on Empirical Methods in Natural Language Processing","author":"Saravia"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.patcog.2007.02.007"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1109\/BigData50022.2020.9378065","article-title":"Sosnet: A graph convolutional network approach to fine-grained cyberbullying detection","volume-title":"2020 IEEE International Conference on Big Data (Big Data)","author":"Wang","year":"2020"},{"key":"ref34","article-title":"Gisette","volume-title":"UCI Machine Learning Repository","author":"Guyon","year":"2004"},{"key":"ref35","article-title":"House prices - advanced regression techniques","volume-title":"DataCanary","author":"Montoya","year":"2016"},{"key":"ref36","article-title":"ISOLET","volume-title":"UCI Machine Learning Repository","author":"Cole","year":"1991"},{"key":"ref37","article-title":"Madelon","author":"Guyon","year":"2004","journal-title":"UCI Machine Learning Repository"},{"key":"ref38","volume-title":"MNIST Dataset \u2014 kaggle.com","author":"LeCun","year":"2025"},{"key":"ref39","first-page":"361","article-title":"Rcv1: A new benchmark collection for text categorization research.","volume":"5","author":"Lewis","year":"2004","journal-title":"Journal of Machine Learning Research"},{"key":"ref40","first-page":"331","article-title":"Newsweeder: Learning to filter netnews","volume-title":"Proceedings of the Twelfth International Conference on Machine Learning","author":"Lang","year":"1995"},{"key":"ref41","volume-title":"190k+ spam - ham email dataset for classification","author":"Likith","year":"2024"},{"key":"ref42","volume-title":"The uci machine learning repository","author":"Kelly","year":"2024"},{"key":"ref43","year":"2024","journal-title":"Kaggle: Your machine learning and data science community"},{"issue":"11","key":"ref44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i11","article-title":"Feature selection with the boruta package","volume":"36","author":"Kursa","year":"2010","journal-title":"Journal of Statistical Software"},{"key":"ref45","article-title":"Benchmarking relief-based feature selection methods","volume-title":"arXiv e-print","author":"Urbanowicz","year":"2017"}],"event":{"name":"2025 IEEE International Conference on Big Data (BigData)","location":"Macau, China","start":{"date-parts":[[2025,12,8]]},"end":{"date-parts":[[2025,12,11]]}},"container-title":["2025 IEEE International Conference on Big Data (BigData)"],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/11400704\/11400712\/11402619.pdf?arnumber=11402619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T06:58:40Z","timestamp":1772866720000},"score":7.6494617,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11402619\/"}},"issued":{"date-parts":[[2025,12,8]]},"references-count":45,"URL":"https:\/\/doi.org\/10.1109\/bigdata66926.2025.11402619","published":{"date-parts":[[2025,12,8]]}},{"indexed":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T04:13:02Z","timestamp":1656130382356},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"13_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Abstract<\/jats:title>\n Ovarian cancer is one of the most common malignancies, accounting for more deaths than any other cancer of the female reproductive system. Cyclin-dependent kinases 4 and 6 (CDK4\/6) are fundamental drivers of the cell cycle and are required for the initiation and progression of various cancers. Over-expression of CDK4\/6 &\/or cyclin D1 is commonly observed in ovarian cancer and is associated with an aggressive phenotype and poor prognosis. Patients with advanced ovarian cancer whose tumor demonstrated Rb-positive & a low expression of p16INK4a have the worst clinical outcome, but these patients are likely to gain benefit from CDK4\/6 inhibition. Here, we describe the preclinical development of 2-94; a potent, highly selective and orally bioavailable CDK4 inhibitor for the treatment of ovarian cancer. Specifically, 2-94 exhibits high selectivity for CDK4\/D1 (Ki = 2 nM) over CDK6\/D3 (Ki = 279 nM). Consistent with a CDK4-targeted mechanism, 2-94 potently inhibited proliferation of Rb proficient ovarian cancer cells. It induced G1 cell cycle arrest by reducing Rb phosphorylation at S780, S795 and S807\/11 residues in a dose dependent manner. Apoptosis was induced with evident increase of caspase 3\/7 activity and reduction of Bcl-2 protein levels in A2780 cells. In addition, 2-94 has shown synergistic activity with mTOR, MEK, PI3K and PARP inhibitors. In contrast, no apparent cell cycle effect, senescence or apoptosis was observed in human bone marrow mononuclear (hBMNCs) cells by 2-94 treatment unlike palbociclib and ribociclib which increased the G1 population of hBMNCs, suggesting the low toxicity of 2-94 compared to clinical compounds. Consistent with its favourable pharmacokinetic properties and high oral bioavailability, 2-94 delayed tumor growth and significantly increased the survival of A2780 tumor bearing nude mice by oral administration. 2-94 was more efficacious when compared to palbociclib, resulting in a T\/C = 22% for 2-94 vs T\/C = 31% for palbociclib. Moreover, 2-94 showed little or no effect on lymphocyte and neutrophil counts whilst palbociclib caused their reduction. This lower effect of 2-94 on the neutrophils and lymphocytes might be due to its lesser effect on CDK6-cyclin D3 compared to palbociclib. Both 2-94 and palbociclib didn't cause histopathological changes in the bone marrow, intestine, liver, heart and kidney of the mice. Pharmacodynamical studies confirmed that 2-94 reduced the Rb phosphorylation at S780, S795 and S807\/811 in the tumour models. In conclusion, 2-94 is a first-in-class CDK4 inhibitor with high selectivity against a panel of 360 human kinases. This selectivity can be taken as a reason for the observed better safety of 2-94 compared to palbociclib. The favourable oral pharmacokinetics, robust antitumor efficacy and excellent safety profiles make 2-94 a highly attractive candidate for development towards the clinic.<\/jats:p>\n Citation Format: Laychiluh B. Mekonnen, Solomon Zeleke, Jimma Lenjisa, Mingfeng Yu, Benjamin Noll, Gary Heinemann, Robert Milne, Hugo Albrecht, Martin K. Oehler, Shudong Wang. A first-in-class CDK4 inhibitor shows excellent in vitro and in vivo efficacy against ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1524.<\/jats:p>","DOI":"10.1158\/1538-7445.am2018-1524","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T20:25:10Z","timestamp":1534537510000},"page":"1524-1524","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 1524: A first-in-class CDK4 inhibitor shows excellent in vitro and in vivo efficacy against ovarian cancer"],"prefix":"10.1158","volume":"78","author":[{"given":"Laychiluh B.","family":"Mekonnen","sequence":"first","affiliation":[{"name":"1University of South Australia, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon","family":"Zeleke","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimma","family":"Lenjisa","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingfeng","family":"Yu","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Noll","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Heinemann","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Milne","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Albrecht","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin K.","family":"Oehler","sequence":"additional","affiliation":[{"name":"2Royal Adelaide Hospital, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shudong","family":"Wang","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/78\/13_Supplement\/1524\/625754\/Abstract-1524-A-first-in-class-CDK4-inhibitor","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/78\/13_Supplement\/1524\/625754\/Abstract-1524-A-first-in-class-CDK4-inhibitor","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T03:46:25Z","timestamp":1656128785000},"score":7.6493955,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/78\/13_Supplement\/1524\/625754\/Abstract-1524-A-first-in-class-CDK4-inhibitor"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"13_Supplement","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2018-1524","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2018,7,1]]}},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:14:01Z","timestamp":1651209241103},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.juro.2016.02.513","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T07:35:14Z","timestamp":1459150514000},"source":"Crossref","is-referenced-by-count":0,"title":["MP53-16 OUTCOMES AND SAFETY PROFILE OF TRANSPERINEAL PROSTATE BIOPSY: RESULTS FROM THE VICTORIAN TRANSPERINEAL BIOPSY COLLABORATION"],"prefix":"10.1097","volume":"195","author":[{"given":"Sean","family":"Huang","sequence":"first","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Declan","family":"Murphy","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homayoun","family":"Zargar","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mann","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Tjandra","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wee Loon","family":"Ong","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Moon","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Lawrentschuk","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Frydenberg","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Grummet","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534716008016?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534716008016?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2016.02.513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T04:57:54Z","timestamp":1651208274000},"score":7.6490955,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2016.02.513"}},"issued":{"date-parts":[[2016,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1016\/j.juro.2016.02.513"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2016.02.513","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2016,4]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:14Z","timestamp":1753889834457,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"This study aimed to estimate the long-term risk of End-Stage Kidney Disease (ESKD) in type 2 diabetes. We included 1,113,201 people with type 2 diabetes registered on the Australian National Diabetes Services Scheme (NDSS) followed from 2002 until 2013. The NDSS was linked to the Australia and New Zealand Dialysis and Transplant Registry and the National Death Index to obtain incident renal replacement therapy (RRT) and death, respectively. Between 2002 and 2013, 7,592 NDSS registrants initiated RRT over 7,839,075 person-years of follow up. The incidence of RRT increased with increasing duration of diabetes. In the first 10-15 years after onset of diabetes, incidence of RRT was highest in those with older age at onset of diabetes. However, over longer durations of diabetes, the cumulative incidence of RRT became higher in those with younger onset diabetes. When \u201ctotal\u201d incidence of ESKD (RRT and deaths attributed to ESKD without RRT) was considered, the predicted lifetime risks of renal failure (until age 100) were 20.1%, 16.1%, 11.6%, 7.7%, 5.4%, and 4.2% in those with diabetes onset between ages 10-29, 30-39, 40-49, 50-59, 60-69, and 70-79, respectively. Thus, the long-term risk of ESKD in type 2 diabetes is high, which disproportionately affects those with younger-onset type 2 diabetes as they are more likely to survive to longer diabetes durations.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n J.I. Morton: None. D. Liew: None. S. McDonald: None. J.E. Shaw: Advisory Panel; Self; AstraZeneca, Merck Sharp & Dohme Corp., Mylan, Sanofi. Research Support; Self; AstraZeneca. Speaker\u2019s Bureau; Self; Eli Lilly and Company, Mylan. D.J. Magliano: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Australian Government Research Training Program (to J.I.M.); Monash University (to J.I.M.)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-282-or","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:49Z","timestamp":1592238589000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["282-OR: The Association of Age of Onset of Type 2 Diabetes with Long-Term Risk of End Stage Kidney Disease: A National Registry Study"],"prefix":"10.2337","volume":"69","author":[{"given":"JEDIDIAH I.","family":"MORTON","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DANNY","family":"LIEW","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN","family":"MCDONALD","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JONATHAN E.","family":"SHAW","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DIANNA J.","family":"MAGLIANO","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/282-OR\/56861\/282-OR-The-Association-of-Age-of-Onset-of-Type-2","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/282-OR\/56861\/282-OR-The-Association-of-Age-of-Onset-of-Type-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:51:03Z","timestamp":1647165063000},"score":7.6490955,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/282-OR\/56861\/282-OR-The-Association-of-Age-of-Onset-of-Type-2"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-282-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"282-OR"},{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:22:30Z","timestamp":1781536950168,"version":"3.54.5"},"reference-count":110,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bpspsychub.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brit J of Edu Psychol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Boarding students face unique challenges when entering school, including: adapting to a novel environment, where they are separated from family, friends and culture, for up to 40\u2009weeks per year. A particular challenge is sleep. A further challenge is coping with the demands of boarding with its potential impact on psychological well\u2010being.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n To explore how boarders' sleep differs from that of their day\u2010student peers, and how this relates to psychological well\u2010being.<\/jats:p>\n <\/jats:sec>\n \n Sample and Methods<\/jats:title>\n 309 students (59 boarding students and 250\u2009day\u2010students, at one Adelaide school) completed the School Sleep Habits Survey, Depression\u2010Anxiety\u2010Stress\u2010Scale\u201021 (DASS\u201021), and Flourishing Scale. Boarding students additionally completed the Utrecht Homesickness Scale. Thirteen boarding students described experiences of sleeping in boarding through focus groups.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Boarding students, compared to day\u2010students reported 40\u2009minutes more sleep per weeknight (\n p<\/jats:italic>\n \u2009<\u2009.001), with earlier sleep onset (\n p<\/jats:italic>\n \u2009=\u2009.026), and later wake\u2010up (\n p<\/jats:italic>\n \u2009=\u2009.008) times. No significant differences were observed between boarding' and day\u2010students' DASS\u201021 scores. Hierarchical regression revealed longer total weekday sleep time predicted higher psychological well\u2010being in both boarding and day\u2010students. Additionally, in boarding students, low homesickness\u2010loneliness and homesickness\u2010ruminations further predicted psychological well\u2010being. Thematic analysis of boarding students' focus group responses revealed that night\u2010time routine, and restricting technology use at night facilitated sleep.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study supports \u2013 in both boarding and day\u2010students \u2013 the importance of sleep for adolescent well\u2010being. Sleep hygiene can play an important role in boarding student sleep, especially: regular night\u2010time routine and restricting technology use at night. Finally, these findings suggest that poor sleep and homesickness have an adverse effect on boarding student psychological well\u2010being. 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The clinical and biological characteristics of these patients remain poorly defined and as such there are presently no reliable validated biomarkers to distinguish patients requiring the addition of anti-CTLA-4 in the context of anti-PD-1 therapy.<\/jats:p>\n Clinical cohort and methods: We performed RNA sequencing, immunofluorescence-IHC, and multiparameter image-mass cytometry (IMC) on formalin-fixed paraffin embedded (FFPE) tumors at baseline and post anti-PD-1 therapy from n=15 stage IV melanoma patients who failed anti-PD-1 therapy and went on to receive combination immunotherapy (7 non-responders; 8 responders).<\/jats:p>\n Results: Tumor pathological parameters including TIL and neutrophil densities, fibrosis, necrosis and mitotic rates identified were not different between responders and non-responders. While T-reg, cytotoxic CD8 and CD39+ resident CD8 T cells densities were not significantly different, the proportion of TCF7+ CD8 T cells was significantly higher at baseline (p=0.01) and in all tumor samples (p=0.007) in responders compared to non-responders. RNA differential gene expression analysis revealed higher expression of cancer testis antigens (CTAs) in responding patient tumors. Hierarchical clustering of differentially expressed genes separated responding patients from non-responding patients.<\/jats:p>\n Conclusions: The proportion of TCF7+ CD8 T cells and the presence of melanoma cancer testis antigens may be a predictive biomarker of response to combination immunotherapy in patients failing anti-PD-1 monotherapy but requires further validation.<\/jats:p>\n Citation Format: Jarem J. Edwards, In\u00eas Pires da Silva1, Angela Ferguson, Peter Johansson, Jordan Conway, Grace Attrill, Robyn P.M Saw, John F. Thompson, Alexander M. Menzies, Umaimainthan Palendira, Georgina V. Long, Richard A. Scolyer, James S. Wilmott. Defining melanoma patients unresponsive to single agent anti-PD-1 therapy but responsive to combination anti-PD-1 + anti-CTLA-4 therapy [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. 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Assessing physical activity in people with mental illness: 23-country reliability and validity of the Simple Physical Activity Questionnaire (SIMPAQ). BMC Psychiatry 20 Article 108. https:\/\/doi.org\/10.1186\/s12888-020-2473-0","DOI":"10.1186\/s12888-020-2473-0"},{"key":"e_1_3_3_27_1","doi-asserted-by":"crossref","unstructured":"Schweizer K. Austin F. Wright K. Jackson B. Lin A. Strauss P. Furzer B. (2026). Eating and exercise experiences of Australian trans and gender diverse folks: Lived experience and stakeholder perspectives. International Journal of Transgender Health 27(1) 423\u2013446. https:\/\/doi.org\/10.1080\/26895269.2024.2447765","DOI":"10.1080\/26895269.2024.2447765"},{"key":"e_1_3_3_28_1","doi-asserted-by":"crossref","unstructured":"Schweizer K. Austin F. Wright K. E. Lin A. Bickendorf X. Jackson B. Strauss P. Gurevich H. Granger C. Luke J. Furzer B. J. (2023). Physical activity behaviors in trans and gender diverse adults: A scoping review. 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WHO guidelines on physical activity and sedentary behaviour: Recommendations [Internet]. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK566046\/"},{"key":"e_1_3_3_35_1","doi-asserted-by":"crossref","unstructured":"Wright K. E. Jackson B. Licari M. K. Dimmock J. A. Furzer B. J. (2023). Thriving families: The feasibility and preliminary efficacy of a multi-component physical literacy program for children with neurodevelopmental emotional or behavioural problems. Mental Health and Physical Activity 25 100558. https:\/\/doi.org\/10.1016\/j.mhpa.2023.100558","DOI":"10.1016\/j.mhpa.2023.100558"},{"key":"e_1_3_3_36_1","doi-asserted-by":"crossref","unstructured":"Zhou S. Xu Y. Yang Y. Song H. Wang X. Yu Y. (2025). Effect of exercise interventions on depression anxiety and self-esteem in children and adolescents: A systematic review and network meta-analysis. BMC Public Health 25(1) Article 3706. https:\/\/doi.org\/10.1186\/s12889-025-25044-6","DOI":"10.1186\/s12889-025-25044-6"}],"container-title":["Health Education & Behavior"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10901981261479283","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10901981261479283","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10901981261479283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:17:47Z","timestamp":1788196667000},"score":7.6481495,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10901981261479283"}},"issued":{"date-parts":[[2026,8,28]]},"references-count":35,"alternative-id":["10.1177\/10901981261479283"],"URL":"https:\/\/doi.org\/10.1177\/10901981261479283","ISSN":["1090-1981","1552-6127"],"issn-type":[{"value":"1090-1981","type":"print"},{"value":"1552-6127","type":"electronic"}],"published":{"date-parts":[[2026,8,28]]},"article-number":"10901981261479283"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:54:23Z","timestamp":1753876463128,"version":"3.41.2"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2023,11,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Home inotropic support is an established bridge to cardiac transplantation in patients with advanced heart failure. Milrinone, a phosphodiesterase 3 inhibitor, preferentially vasodilates pulmonary vasculature, thus is often chosen over dobutamine in patients with concomitant pulmonary hypertension. However, there is a paucity of data on the haemodynamic effects of milrinone in the pre-cardiac transplant population.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n We sought to examine the haemodynamic effects of milrinone vs. dobutamine out to 3 months in patients with advanced heart failure awaiting cardiac transplantation.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients in the home inotrope program at a quaternary referral centre from January 2000 to May 2022 were included. Retrospective analysis of echocardiographic and invasive haemodynamic studies via right heart catheterisation were performed at baseline (prior to commencement of inotrope), at 30 days (30D) and 3 months (3m).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n From a total of 119 patients, 57 were on milrinone and 62 on dobutamine. Non-ischaemic cardiomyopathies of various aetiologies accounted for 67%, while ischaemic cardiomyopathies accounted for 33%. Majority of patients were male (79%) with a mean age of 52\u00b113 years. There was a significant increase in LVEF from 21\u00b17% at baseline to 27\u00b114% at 3m in those on dobutamine, p = 0.02. Similar increase in LVEF from 22\u00b18% to 26\u00b113% in the milrinone group did not reach significance, p = 0.43. Comparably, CI increased from 2.0\u00b10.6L\/min\/m2 at baseline to 2.5\u00b10.9L\/min\/m2 at 3m in the dobutamine cohort, p = 0.05, and from 2.0\u00b10.7L\/min\/m2 at baseline to 2.3\u00b10.6L\/min\/m2 at 3m in the milrinone cohort, p = 0.27. In the dobutamine cohort LVEDD was static from 68\u00b114mm at baseline to 66\u00b121mm at 3m, p = 0.78. LVEDD reduced from 67\u00b111mm to 60\u00b1 9mm at 3m in the milrinone group, p = 0.09. Classification of mild right ventricular dysfunction increased from 7% to 18% after 30 days on milrinone, p= 0.2, compared to an increase from 10% to 16% in the dobutamine group, p = 0.47. Mean pulmonary artery pressure (mPAP) reduced from 34\u00b111mmHg to 29\u00b111mmHg at 3m in the milrinone group, p = 0.15. mPAP was static in the dobutamine group from 34\u00b19mmHg at baseline to 34\u00b110mmHg at 3m, p = 0.96. TPG in the milrinone group was 11.9\u00b16.0mmHg to 12.9\u00b16.3mmHg at 30D, with reduction at 3m to 9.6\u00b16.3mmHg, p = 0.26. In the dobutamine group TPG remained static from 10.9\u00b15.7mmHg at baseline to 11.4\u00b15.1mmHg at 30D and 10.9\u00b15.2 at 3m, p = 0.97. Wedge pressure (PCWP) reduced from 22\u00b17mmHg at baseline to 21\u00b17mmHg at 30D to 18\u00b18mmHg at 3m in the milrinone group, p = 0.11. PCWP in the dobutamine group was static at 23\u00b18mmHg at baseline to 24\u00b15mmHg at 30D and 23\u00b16mmHg at 3m, p = 0.92.<\/jats:p>\n <\/jats:sec>\n \n Conclusion(s)<\/jats:title>\n Dobutamine demonstrated a significant increase in LVEF and CI out to 3 months, however milrinone demonstrated a larger improvement in RV function and greater reduction in cardiac and pulmonary pressures as compared to dobutamine. Larger studies are required to confirm these trends.Figure 1<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehad655.785","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T07:13:30Z","timestamp":1699686810000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparison of milrinone versus dobutamine on invasive haemodynamics in patients with advanced heart failure on home inotropes"],"prefix":"10.1093","volume":"44","author":[{"given":"M","family":"Dagan","sequence":"first","affiliation":[{"name":"Nil , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Lankaputhra","sequence":"additional","affiliation":[{"name":"Nil , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Yeung","sequence":"additional","affiliation":[{"name":"Nil , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Warner","sequence":"additional","affiliation":[{"name":"Nil , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Easton","sequence":"additional","affiliation":[{"name":"Nil , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Linton","sequence":"additional","affiliation":[{"name":"Nil , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Downes","sequence":"additional","affiliation":[{"name":"Nil , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Vizi","sequence":"additional","affiliation":[{"name":"Nil , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Leet","sequence":"additional","affiliation":[{"name":"Nil , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hare","sequence":"additional","affiliation":[{"name":"Nil , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Taylor","sequence":"additional","affiliation":[{"name":"Nil , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Bergin","sequence":"additional","affiliation":[{"name":"Nil , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Patel","sequence":"additional","affiliation":[{"name":"Nil , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Kaye","sequence":"additional","affiliation":[{"name":"Nil , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,11,9]]},"container-title":["European Heart Journal"],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/44\/Supplement_2\/ehad655.785\/53600472\/ehad655.785.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/44\/Supplement_2\/ehad655.785\/53600472\/ehad655.785.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T23:36:14Z","timestamp":1700609774000},"score":7.647738,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/doi\/10.1093\/eurheartj\/ehad655.785\/7391702"}},"issued":{"date-parts":[[2023,11]]},"references-count":0,"journal-issue":{"issue":"Supplement_2","published-online":{"date-parts":[[2023,11,9]]},"published-print":{"date-parts":[[2023,11,9]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehad655.785","ISSN":["0195-668X","1522-9645"],"issn-type":[{"type":"print","value":"0195-668X"},{"type":"electronic","value":"1522-9645"}],"published-other":{"date-parts":[[2023,11]]},"published":{"date-parts":[[2023,11]]},"article-number":"ehad655.785"},{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:06:34Z","timestamp":1779375994565,"version":"3.53.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2026,5,1]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Early detection and treatment of obstructive sleep apnea (OSA) improves health outcomes and reduces healthcare costs, yet under-recognition and limited access to diagnostic testing remain major barriers. Conventional in-lab and home sleep studies require specialized sensors and personnel, creating significant delays and costs. There is a strong need for accessible, low-cost diagnostic tools that can identify OSA beyond traditional symptom-based screening. We developed novel smartphone-based application that integrates multiple data modalities which show promise of detecting OSA; including facial imaging, video assessments (speech, swallowing, blinking), heart rate variability, and targeted questionnaires. A pilot study is underway to assess the utility of the app for predicting OSA risk.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this pilot study, participants referred for suspected OSA across multiple sleep centres completed the app-based assessment prior to undergoing a standard home sleep test (HST). Associations between app digital biomarkers and HST derived Apnea-hypopnea index (AHI) and oxygen desaturation index (ODI) were analysed using correlation and multivariable regression to assess predictive validity.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n To date, 456 participants have been analysed (37.5% female; age distribution: 3% aged &lt;20, 28% aged 20-40, 46% aged 40-60, 15% aged 60-70, and 7% aged 70-99).<\/jats:p>\n Among participants with available AHI data (n\u2009=\u2009339): 17% had AHI &lt;5, 27% had AHI 5-14, 24% had AHI 15-30, and 31% had AHI &gt;30. Racial distribution included 59% White, 23% Asian, 6% Black or African American, 4% Middle Eastern or North African, and 8% other. Preliminary modelling indicates the potential to achieve &gt;80% sensitivity and specificity for OSA detection relative to AHI \u226515 defined diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This novel smartphone-based diagnostic app demonstrates promising accuracy in identifying OSA using multimodal digital biomarkers. Early results support its potential as a home-based, low-cost diagnostic solution. A larger prospective validation study across diverse populations is warranted to confirm clinical performance and generalizability.<\/jats:p>\n This abstract is funded by: Resmed<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ajrccm\/aamag162.6354","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:09:42Z","timestamp":1779145782000},"source":"Crossref","is-referenced-by-count":0,"title":["B37-07 Development of a Cost-Effective, Fast, Home-Based Diagnostic App for Obstructive Sleep Apnea (Osa)"],"prefix":"10.1093","volume":"212","author":[{"given":"A","family":"Wimms","sequence":"first","affiliation":[{"name":"ResMed Science Center , Sydney,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lim Zhi Guang","sequence":"additional","affiliation":[{"name":"ResMed, Sydney, 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disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1742-6723.14378","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T04:52:31Z","timestamp":1708404751000},"page":"479-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Renal disease is not associated with delays in hyperacute stroke management in South Australia"],"prefix":"10.1111","volume":"36","author":[{"given":"Rudy","family":"Goh","sequence":"first","affiliation":[{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5130-8628","authenticated-orcid":false,"given":"Stephen","family":"Bacchi","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South 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We conducted a systematic review of randomised control trials (RCT) comparing chemotherapy regimens with or without capecitabine in HR positive and HR negative breast cancer.<\/jats:p>\n Methods<\/jats:p>\n This review was conducted by standard Cochrane review procedures. Our protocol has been published previously. We conducted a comprehensive literature search including MEDLINE, EMBASE, CENTRAL databases, clinical trial registries and major oncology conferences for capecitabine RCTs. 1913 references were identified with 209 suitable for detailed review. 62 RCTs (40 metastatic, 13 adjuvant, 9 neoadjuvant) comparing chemotherapy regimens with or without capecitabine were identified. 21 studies (10 metastatic, 7 adjuvant, 4 neoadjuvant) reporting outcome data by HR status proceeded to full data extraction. 2 studies reported comprehensive outcome data by HR status, the remainder reporting by hazard or odds ratios only.<\/jats:p>\n Results<\/jats:p>\n In metastatic trials, capecitabine significantly improved outcomes for HR positive but not HR negative disease for chemotherapy alone (SO14999 trial \u2013 odds ratio (OR) for OS 0.65 (95% CI 0.47-0.89) v 0.90 (0.65-1.24) and possibly with additional trastuzumab (CHAT trial \u2013 OR for PFS 0.61 v 0.87 (significance not reported)). Significant benefit was seen for adding capecitabine to bevacizumab after taxane completion only in HR positive disease (IMELDA trial \u2013 OR for PFS 0.33 (0.22-0.50) v 0.70 (0.39-1.25)). In contrast, adding capecitabine to a taxane with bevacizumab showed the reverse with only HR negative patients benefiting (TABEA trial \u2013 OR for PFS 1.49 (0.99-2,24) v 0.51 (0.269-0.959)).<\/jats:p>\n Adjuvant trials investigating the addition of capecitabine to anthracycline-taxane containing regimens or as monotherapy in elderly patients. Preliminary analysis indicates HR negative cancers benefit from the addition of capecitabine compared to non-capecitabine containing regimens. No observed benefit in HR positive disease with the addition of capecitabine was been demonstrated.<\/jats:p>\n Odds ratio for outcomes by the addition of capecitabine to adjuvant chemotherapyOutcomeNo. trialsHR GroupOR95% CIp valueDFS6All0.920.83-1.020.11\u00a05HR positive1.050.91-1.220.50\u00a04HR negative0.720.58-0.880.002RFS1All0.880.71-1.090.07\u00a01HR positive0.990.77-1.270.94\u00a02HR negative0.630.46-0.870.005OS6All0.900.80-1.030.12\u00a01HR positive0.710.45-1.120.14\u00a01HR negative0.640.44-0.930.02<\/jats:p>\n Neoadjuvant trials investigating the utility of capecitabine to anthracycline-taxane containing regimens showed no additional benefit with respect to pCR. Meta-analysis of response rates for all patients and differentiated by HR status showed no significant difference on inclusion of capecitabine.<\/jats:p>\n Conclusion<\/jats:p>\n In summary, metastatic and neoadjuvant trials did not show clear differential benefit of capecitabine in HR positive versus HR negative breast cancer. HR positive tumours in the metastatic setting might be more responsive to capecitabine. Additional benefit to an anthracycline-taxane containing regimens with capecitabine in the adjuvant setting was confined to HR negative cancers. Final results of our analysis will be presented.<\/jats:p>\n Citation Format: Redfern A, Lau P, White A, Hoon S, Bulsara M, Long A. Cochrane review of capecitabine for hormone receptor positive versus hormone receptor negative breast cancer [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P2-12-02.<\/jats:p>","DOI":"10.1158\/1538-7445.sabcs16-p2-12-02","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:06:34Z","timestamp":1488326794000},"page":"P2-12-02-P2-12-02","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract P2-12-02: Cochrane review of capecitabine for hormone receptor positive versus hormone receptor negative breast cancer"],"prefix":"10.1158","volume":"77","author":[{"given":"A","family":"Redfern","sequence":"first","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia; Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia; Saint John of God Hospital - Subiaco, Perth, Western Australia, Australia; Westmead Hospital, Sydney, New South Wales, Australia; Universtiy of Notre Dane, Fremantle, Western Australia, Australia; Hollywood Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Lau","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia; Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia; Saint John of God Hospital - Subiaco, Perth, Western Australia, Australia; Westmead Hospital, Sydney, New South Wales, Australia; Universtiy of Notre Dane, Fremantle, Western Australia, Australia; Hollywood Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"White","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia; Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia; Saint John of God Hospital - Subiaco, Perth, Western Australia, Australia; Westmead Hospital, Sydney, New South Wales, Australia; Universtiy of Notre Dane, Fremantle, Western Australia, Australia; Hollywood Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Hoon","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia; Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia; Saint John of God Hospital - Subiaco, Perth, Western Australia, Australia; Westmead Hospital, Sydney, New South Wales, Australia; Universtiy of Notre Dane, Fremantle, Western Australia, Australia; Hollywood Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bulsara","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia; Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia; Saint John of God Hospital - Subiaco, Perth, Western Australia, Australia; Westmead Hospital, Sydney, New South Wales, Australia; Universtiy of Notre Dane, Fremantle, Western Australia, Australia; Hollywood Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Long","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia; Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia; Saint John of God Hospital - Subiaco, Perth, Western Australia, Australia; Westmead Hospital, Sydney, New South Wales, Australia; Universtiy of Notre Dane, Fremantle, Western Australia, Australia; Hollywood Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/77\/4_Supplement\/P2-12-02\/623784\/Abstract-P2-12-02-Cochrane-review-of-capecitabine","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/77\/4_Supplement\/P2-12-02\/623784\/Abstract-P2-12-02-Cochrane-review-of-capecitabine","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T02:32:14Z","timestamp":1656124334000},"score":7.6464744,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/77\/4_Supplement\/P2-12-02\/623784\/Abstract-P2-12-02-Cochrane-review-of-capecitabine"}},"issued":{"date-parts":[[2017,2,15]]},"references-count":0,"journal-issue":{"issue":"4_Supplement","published-print":{"date-parts":[[2017,2,15]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.sabcs16-p2-12-02","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2017,2,15]]}},{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T18:00:23Z","timestamp":1648663223819},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"suppl_1","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2017,7,1]]},"DOI":"10.1093\/geroni\/igx004.3055","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T19:43:38Z","timestamp":1498851818000},"page":"848-848","source":"Crossref","is-referenced-by-count":0,"title":["FACILITATING CONSUMER-DIRECTED DECISION MAKING IN LONG-TERM CARE: RESULTS FROM A CITIZENS\u2019 JURY"],"prefix":"10.1093","volume":"1","author":[{"given":"M.","family":"Cations","sequence":"first","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia,"},{"name":"UNSW Australia, Sydney, South Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Laver","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ratcliffe","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kurrle","sequence":"additional","affiliation":[{"name":"University of Sydney, Sydney, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Shulver","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Crotty","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,6,30]]},"container-title":["Innovation in Aging"],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/innovateage\/article-pdf\/1\/suppl_1\/848\/26123341\/igx004.3055.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T12:03:46Z","timestamp":1540209826000},"score":7.6461577,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/innovateage\/article\/1\/suppl_1\/848\/3900110"}},"issued":{"date-parts":[[2017,6,30]]},"references-count":0,"journal-issue":{"issue":"suppl_1","published-online":{"date-parts":[[2017,6,30]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/geroni\/igx004.3055","ISSN":["2399-5300"],"issn-type":[{"value":"2399-5300","type":"electronic"}],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2017,6,30]]}},{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T11:34:59Z","timestamp":1743075299930},"reference-count":0,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"15_suppl","funder":[{"name":"None"}],"content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2021,5,20]]},"abstract":" e18812 <\/jats:p> Background: Australian oncologists reported dramatic decreases in cancer referrals during the pandemic. As real time data were difficult to acquire, Cancer Australia used surrogate measures to infer where reductions in medical services occurred. We analysed data available through the Medicare Benefits Schedule (MBS), a list of the medical services and professional attendances subsidised by the Australian Government, for the five highest incidence cancers: breast, colorectal, lung, prostate, and skin cancers. Methods: We identified over 500 MBS item codes for diagnostic and treatment procedures for malignancies and pre-cancerous conditions. Item codes were categorised into analysis groups based on cancer type and\/or similarities in type of service. Data were examined at national and jurisdictional levels for 2020 to determine reductions during the initial COVID-19 period and to monitor subsequent recovery. Data were compared to 2019 to account for normal seasonal variation. Results: Australia\u2019s first wave of the pandemic ran from March to May, and a second wave in the state of Victoria alone ran from July to September 2020. We observed notable reductions across all diagnostic and surgical procedure groups examined, with initial reductions observed between March and April for diagnostic procedures, and a one-month delay for surgical procedures, between April and May. Some services showed an initial recovery in May, with many showing partial or full recovery by June. For some groups, analyses showed sustained reductions over the 12-month period. While COVID-19 case numbers were greater during the second wave, the impact on services was less pronounced, likely owing to more refined policy approaches to managing health system and workforce capacity. There was further recovery by September for some but not all services. Similar patterns of change were observed across all Australian states and territories, with some variation by jurisdiction. Conclusions: The pandemic has impacted the delivery of cancer care. Any potential delays in diagnoses and treatment due to these reductions in services may lead to more advanced cancer stage at diagnosis and poorer patient outcomes including recurrence and survival. Impact of COVID-19 on selected cancer services in Australia in 2020.[Table: see text] <\/jats:p>","DOI":"10.1200\/jco.2021.39.15_suppl.e18812","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T14:28:38Z","timestamp":1622644118000},"page":"e18812-e18812","update-policy":"http:\/\/dx.doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["The COVID-19 pandemic led to a reduction in cancer services in Australia."],"prefix":"10.1200","volume":"39","author":[{"given":"Christine","family":"Biondi","sequence":"first","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivienne","family":"Milch","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Ryan","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Roder","sequence":"additional","affiliation":[{"name":"South Australian Health & Medical Research Institute (SAHMRI), Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Woods","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristie","family":"Cooper","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhona","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleola","family":"Anderiesz","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy Mary Kate","family":"Keefe","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","container-title":["Journal of Clinical Oncology"],"language":"en","deposited":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T15:02:02Z","timestamp":1622646122000},"score":7.645596,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2021.39.15_suppl.e18812"}},"issued":{"date-parts":[[2021,5,20]]},"references-count":0,"journal-issue":{"issue":"15_suppl","published-print":{"date-parts":[[2021,5,20]]}},"alternative-id":["10.1200\/JCO.2021.39.15_suppl.e18812"],"URL":"https:\/\/doi.org\/10.1200\/jco.2021.39.15_suppl.e18812","ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"published":{"date-parts":[[2021,5,20]]},"assertion":[{"value":"2021-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:12:49Z","timestamp":1787019169888,"version":"build-2736575974"},"reference-count":55,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT190100077"],"award-info":[{"award-number":["FT190100077"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003521","name":"Department of Education, Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003521","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Autism"],"published-print":{"date-parts":[[2025,4]]},"abstract":"Successful partnerships between families and schools can substantially improve children\u2019s success in and out of school. Yet parents of autistic children often report considerable challenges with their children\u2019s education. Almost no research, however, has examined autistic parents\u2019 own experiences. We, therefore, sought the views and experiences of autistic parents\u2019 interactions with schools for their autistic children. We conducted semi-structured interviews with 31 autistic mothers of autistic children engaged in education in Australia. We analysed the data using reflexive thematic analysis. Autistic mothers repeatedly expressed feeling like they were in a \u2018war zone\u2019, fighting ongoing battles to gain the necessary support for their autistic child and were \u2018sick of being [viewed as] the problem\u2019. They also felt that their expertise as parents \u2013 and experiential expertise as autistic parents \u2013 was often overlooked or ignored. All of this had negative effects on their and their children\u2019s mental health. Despite these negative experiences, autistic mothers who had experienced positive interactions with schools highlighted the importance of mutual respect in establishing and maintaining successful school partnerships and how their own determination and self-advocacy helped to foster these relationships. This research sheds light on the critical ingredients of effective home\u2013school partnerships for autistic families.<\/jats:p>\n \n Lay abstract<\/jats:title>\n Good relationships between families and schools make a difference to children\u2019s learning \u2013 and the same goes for autistic children. But parents of autistic children often find it very stressful interacting with teachers and school staff. In this study, we focused on autistic parents of autistic children. We wanted to know about their experiences of interacting with schools and the impact these had on them and their children. We spoke to 31 autistic mothers of autistic children about their experiences. They told us that they felt they were constantly fighting with schools to get the support needed for their autistic children and compared it to like being in a \u2018war zone\u2019. They were \u2018sick of being [viewed as] the problem\u2019 and felt that their views and autistic expertise were not taken seriously by teachers and schools. This was damaging to their autistic children\u2019s mental health as well as their own. Autistic mothers did share some positive experiences too. They spoke about the value of mutual respect and its impact on successful school partnerships. Autistic mothers also spoke about standing up for themselves and their children and how this advocacy and self-advocacy helped them to build better relationships with schools. This research showed how difficult it can be for autistic families to interact with teachers and schools and the impact this can have on the whole family. It also showed us that strong, trusting relationships between school and families are possible \u2013 when autistic parents feel safe, and when their knowledge and lived experience are taken seriously by educators.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/13623613241297223","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T01:17:08Z","timestamp":1732497428000},"page":"1034-1046","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["\u2018I\u2019m sick of being the problem\u2019: Autistic mothers\u2019 experiences of interacting with schools for their autistic children"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4320-951X","authenticated-orcid":false,"given":"Aspasia Stacey","family":"Rabba","sequence":"first","affiliation":[{"name":"Macquarie University, Australia"},{"name":"Monash University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3528-0658","authenticated-orcid":false,"given":"Jodie","family":"Smith","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"},{"name":"La Trobe University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Hall","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"},{"name":"University of Technology Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7124-8836","authenticated-orcid":false,"given":"Vanessa","family":"Alexander","sequence":"additional","affiliation":[{"name":"Positive Partnerships, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Batty","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poulomee","family":"Datta","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Goodall","sequence":"additional","affiliation":[{"name":"Positive Partnerships, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Heyworth","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"},{"name":"Reframing Autism, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan","family":"Lamb","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenn","family":"Lawson","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozanna","family":"Lilley","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy","family":"Reid","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najeeba","family":"Syeda","sequence":"additional","affiliation":[{"name":"Positive Partnerships, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7246-8003","authenticated-orcid":false,"given":"Elizabeth","family":"Pellicano","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"},{"name":"University College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,24]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_3_4_3_1","doi-asserted-by":"crossref","unstructured":"Ashburner J. Saggers B. Campbell M. A. Dillon-Wallace J. A. Hwang Y.-S. Carrington S. Bobir N. (2019). How are students on the autism spectrum affected by bullying? Perspectives of students and parents. Journal of Research in Special Educational Needs 19(1) 27\u201344. https:\/\/doi.org\/10.1111\/1471-3802.12421","DOI":"10.1111\/1471-3802.12421"},{"key":"e_1_3_4_4_1","doi-asserted-by":"crossref","unstructured":"Aub\u00e9 B. Follenfant A. Goudeau S. Derguy C. (2021). Public stigma of autism spectrum disorder at school: Implicit attitudes matter. Journal of Autism and Developmental Disorders 51(5) 1584\u20131597. https:\/\/doi.org\/10.1007\/s10803-020-04635-9","DOI":"10.1007\/s10803-020-04635-9"},{"key":"e_1_3_4_5_1","doi-asserted-by":"crossref","unstructured":"Azad G. Mandell D. S. (2016). Concerns of parents and teachers of children with autism in elementary school. 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We prospectively evaluated the mortality outcomes of COVID\u201019 in Western Australian HSCT patients. A total of 32\/492 (6.5%) HSCT recipients contracted COVID\u201019 during the study, of whom 30\/32 (94%) developed mild or asymptomatic disease. Two allogeneic HSCT patients were hospitalised for severe COVID\u201019; one patient died. Stringent healthcare, social isolation practices, aggressive vaccination programmes and rapid access to COVID\u201019 antivirals may have promoted mild COVID\u201019 illness in Western Australian HSCT patients, resulting in one of the lowest COVID\u201019 mortality rates in HSCT recipients worldwide.<\/jats:p>","DOI":"10.1111\/imj.16368","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T07:09:31Z","timestamp":1712214571000},"page":"664-670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["COVID\u201019<\/scp>\n outcomes in haemopoietic stem cell transplant recipients in Western Australia: the value of vaccination and antiviral therapy"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3741-5835","authenticated-orcid":false,"given":"Jacques A. 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50607"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-0931-4"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16856"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30429-4"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI141777"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01302-5"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16369"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.03.010"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.15263"},{"key":"e_1_2_4_11_1","volume-title":"COVID\u201019 Mortality in Australia: Deaths Registered until 30 April 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Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534716005590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534716005590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2016.02.271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:08:46Z","timestamp":1651208926000},"score":7.643708,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2016.02.271"}},"issued":{"date-parts":[[2016,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1016\/j.juro.2016.02.271"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2016.02.271","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2016,4]]}},{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T20:57:58Z","timestamp":1694638678188},"reference-count":0,"publisher":"Ovid 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Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534710006191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534710006191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2010.02.363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T02:21:20Z","timestamp":1651198880000},"score":7.643708,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2010.02.363"}},"issued":{"date-parts":[[2010,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1016\/j.juro.2010.02.363"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2010.02.363","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2010,4]]}},{"indexed":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T05:15:47Z","timestamp":1678511747155},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Supplement 4","content-domain":{"domain":["www.auajournals.org"],"crossmark-restriction":true},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1097\/01.ju.0000555474.19797.83","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T05:40:57Z","timestamp":1556084457000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["PD14-05\u2003LOW AND HIGH THRESHOLD MECHANOSENSITIVE BLADDER AFFERENT PATHWAYS CONVERGE TO A SIMILAR DISTRIBUTION OF LUMBOSACRAL SPINAL NEURONS"],"prefix":"10.1097","volume":"201","author":[{"given":"Luke","family":"Grundy*","sequence":"first","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Harrington","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashlee","family":"Caldwell","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Castro","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Zagorodnyuk","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Brookes","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Spencer","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Brierley","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"http:\/\/www.auajournals.org\/doi\/pdf\/10.1097\/01.JU.0000555474.19797.83","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T16:14:02Z","timestamp":1678464842000},"score":7.6431255,"resource":{"primary":{"URL":"http:\/\/www.auajournals.org\/doi\/10.1097\/01.JU.0000555474.19797.83"}},"issued":{"date-parts":[[2019,4]]},"references-count":0,"journal-issue":{"issue":"Supplement 4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1097\/01.JU.0000555474.19797.83"],"URL":"https:\/\/doi.org\/10.1097\/01.ju.0000555474.19797.83","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"2019-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T02:27:29Z","timestamp":1779416849803,"version":"3.53.1"},"reference-count":0,"publisher":"Clinical Exercise Physiology Association","issue":"s2","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2026,4]]},"abstract":"\n INTRODUCTION:<\/jats:title>\n Incretin-based medications (eg Ozempic, Mounjaro\/Zepbound) have revolutionised the management of obesity, but their effects on fitness have not been reported. We report the effects of 24weeks treatment with tirzepatide, with and without concomitant resistance exercise, on fitness.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n Participants, 50\u201370years with BMI\u226530, or \u226527kg\/m\u00b2 with \u22651 comorbidity, were randomised to tirzepatide(T) with or without 3 sessions of resistance training\/week at UWA (REX). Indices of aerobic fitness and body composition (DXA) were assessed at baseline and 24weeks.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n Exercise data are reported for 98 participants (T+NEX n=46\u264020\u264226; T+EX n=52\u264024\u264228). Body weight decreased significantly in both groups (T+NEX 99.9\u00b115.3 to 81.8\u00b114.9; T+EX 101.3\u00b113.9 to 84.3\u00b113.6kg, both P<0.001), with no significant difference between groups (\u0394-17.5 vs -17.4kg, P=0.839). Fitness decreased in T+NEX (2.66\u00b10.61 to 2.52\u00b10.66L.min-1 P=0.003), no change occurred in T+EX (2.46\u00b10.59 to 2.44\u00b10.68L.min P=0.569), with significant difference between groups (T+NEX \u0394-0.14; T+EX \u0394-0.02L\/min-1, P=0.041). Fitness normalised to body weight increased in both groups (T+NEX 27.1\u00b16.3 to 30.9\u00b16.9, P<0.001; T+EX 24.3\u00b14.8 to 28.9\u00b16.4ml.kg-1.min-1, P<0.001), with no difference between groups (\u03943.7 vs \u03944.7ml.kg-1.min-1, P=0.16). Normalised to total lean mass (n=44), fitness did not change in either group (T+NEX 48.4\u00b15.2 to 47.9\u00b14.8, P=0.458; T+EX 45.4\u00b15.6 to 45.8\u00b15.9ml.kgLBM-1.min-1, P=0.628), with no difference between groups (\u0394-0.5 vs \u03940.4 ml.kgLBM-1.min-1, P=0.406).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n Tirzepatide induce large decreases in body weight in both groups. In absolute terms (L.min-1), aerobic fitness decreased as a result of T, but resistance training prevented this. When normalised for changes in body weight, both groups showed increases, with a larger impact in T+REX. Normalising for total body lean mass revealed a non-significant increase in T+EX, a decrease in T+NEX. These data provide a unique within-subject insight into the relevance of scaling fitness measures to body composition in humans, and indicate that undertaking exercise while on weight management medications is an important clinical goal.<\/jats:p>\n <\/jats:sec>","DOI":"10.31189\/2165-7629-15-s2.250","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:59:20Z","timestamp":1777341560000},"page":"250","source":"Crossref","is-referenced-by-count":0,"title":["IMPACT OF COMBINED TIRZEPATIDE (MOUNJARO\u00ae\/ZEPBOUND\u00ae) AND RESISTANCE EXERCISE (T-REX) ON AEROBIC FITNESS IN OVERWEIGHT AND OBESE OLDER ADULTS."],"prefix":"10.31189","volume":"15","author":[{"given":"Destiny R","family":"Underwood","sequence":"first","affiliation":[{"name":"University Of Western Australia, Nedlands, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evie","family":"Winterton","sequence":"additional","affiliation":[{"name":"University Of Western Australia, Nedlands, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbey","family":"Green","sequence":"additional","affiliation":[{"name":"University Of Western Australia, Nedlands, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Naylor","sequence":"additional","affiliation":[{"name":"University Of Western Australia, Nedlands, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry","family":"Fegan","sequence":"additional","affiliation":[{"name":"University Of Western Australia, Nedlands, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bu","family":"Yeap","sequence":"additional","affiliation":[{"name":"University Of Western Australia, Nedlands, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Haynes","sequence":"additional","affiliation":[{"name":"University Of Western Australia, Nedlands, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Green","sequence":"additional","affiliation":[{"name":"University Of Western Australia, Nedlands, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16145","container-title":["Journal of Clinical Exercise Physiology"],"link":[{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/15\/s2\/article-p250-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/15\/s2\/article-p250-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/15\/s2\/article-p250-s.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T01:51:52Z","timestamp":1779414712000},"score":7.643106,"resource":{"primary":{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/15\/s2\/article-p250-s.xml"}},"issued":{"date-parts":[[2026,4]]},"references-count":0,"journal-issue":{"issue":"s2"},"URL":"https:\/\/doi.org\/10.31189\/2165-7629-15-s2.250","ISSN":["2165-7629","2165-6193"],"issn-type":[{"value":"2165-7629","type":"electronic"},{"value":"2165-6193","type":"print"}],"published":{"date-parts":[[2026,4]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:55:03Z","timestamp":1753876503151,"version":"3.41.2"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2023,5,24]]},"abstract":"Abstract<\/jats:title>\n \n Funding Acknowledgements<\/jats:title>\n Type of funding sources: Foundation. Main funding source(s): Victor Chang Cardiac Research Institute.<\/jats:p>\n <\/jats:sec>\n \n Background\/aims<\/jats:title>\n Accurate monitoring of trends in acute coronary syndromes (ACS) provides important information on the impacts of primary and secondary prevention. Use of cardiac troponin (cTn) assays with increasing sensitivity and specificity during the past 20 years have likely increased the rates of diagnosis of myocardial infarction (MI), particularly NSTEMI. We aimed to determine the correlation of ICD-coded ACS hospitalisation rates with biomarker-classified ACS rates to inform population-level monitoring of ACS trends in Australia.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We used linked hospitalisation, emergency department, mortality, and pathology data from all tertiary hospitals in Western Australia (WA). We identified all patients aged &gt;20years with a principal diagnosis of STEMI or NSTEMI (ICD-10-AM I21.0-I21.4) or unstable angina (UA) (ICD-10-AM I20.0) from 2001-2017. Creatine kinase (CK) and cTn test results including high-sensitivity (hs-Tn) assays were classified as elevated based on the ESC\/AHA Universal Definition using the upper reference limit value for each assay. We calculated age-standardised rates (ASRs) for ICD-10 coded STEMI, NSTEMI and UA hospitalisations, and those which were cTn positive (cTn+), or any biomarker positive including CK (Bm+). We assessed annual ASR ratios over time (reference: ICD-coded rates) and estimated annual % changes in admissions using Poisson regression models adjusting for 5-year age-group and sex.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The cohort comprised 143,231 ICD-coded ACS hospitalisations for 91,701 patients. 60.5% of the patients were male and 95.2% of the ACS hospitalisations had linked cardiac biomarker records. Despite slightly lower ASRs, Bm+ based rates were consistent with patterns in ICD-coded admissions in both MI sub-types (Figure) with no significant differences stratified by sex. Average annual decline in STEMI admissions was -3.7% (95% CI -4.1%,-3.4%) and -3.2% (95% CI -3.6%, -2.9%) in ICD-coded and Bm+ hospitalisations respectively. The annual rise in ICD-coded NSTEMI ASRs was 4.1% (95% CI 3.9%, 4.4%) which correlated with the 4.4% (95% CI 4.1%, 4.7%) annual rise in Bm+ ACS hospitalisations. The age-standardised rate ratios of ICD-coded to Bm+ were 1.27 and 1.28 for STEMI and NSTEMI respectively in 2001 and remained consistent at 1.29 and 1.30 for STEMI and NSTEMI respectively in 2017, although this was not the case for cTn+:ICD-coded rate ratios. There was an inverse trend between ASRs of ICD-coded NSTEMI and UA over the study period which correlated with use of increasingly sensitive cTn assays. The proportion of UA admissions with Bm+ was consistently low (21%) over the study period.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Despite shifts from CK to cTn and hs-Tn assays during our study period, the present study highlights the validity of using linked hospitalisation data to monitor long term trends in ACS based on cardiac biomarker positivity. Figure legend. Age-standardised hospitalisation rates by classification status in ACS subtypes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwad125.183","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T10:42:00Z","timestamp":1684924920000},"source":"Crossref","is-referenced-by-count":0,"title":["Temporal trends in acute coronary syndrome hospitalisation rates: a comparison of administrative diagnosis coding and cardiac biomarker testing"],"prefix":"10.1093","volume":"30","author":[{"given":"D","family":"Zemedikun","sequence":"first","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Lopez","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hung","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Knuiman","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Youens","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Briffa","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Sanfilippo","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Nedkoff","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,24]]},"container-title":["European Journal of Preventive Cardiology"],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/30\/Supplement_1\/zwad125.183\/50458615\/zwad125.183.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/30\/Supplement_1\/zwad125.183\/50458615\/zwad125.183.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T17:34:59Z","timestamp":1685122499000},"score":7.6428933,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjpc\/article\/doi\/10.1093\/eurjpc\/zwad125.183\/7175853"}},"issued":{"date-parts":[[2023,5,24]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2023,5,24]]},"published-print":{"date-parts":[[2023,5,24]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjpc\/zwad125.183","ISSN":["2047-4873","2047-4881"],"issn-type":[{"type":"print","value":"2047-4873"},{"type":"electronic","value":"2047-4881"}],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2023,5,24]]},"article-number":"zwad125.183"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:37Z","timestamp":1753889857621,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"Introduction: Euglycemic hyperinsulinemic clamps, although costly, time- and labor-intensive, are \u201cgold standard\u201d in measuring insulin sensitivity (IS). Several formulae to estimate IS in people with Type 1 diabetes (T1D) exist (DOI: 10.1007\/978-3-030-81303-1_18-1), using various routine and research assays, and with wide ranging IS results.<\/jats:p>\n Aim: To develop a free online tool to estimate IS using different metrics and existent formulae and compare estimated IS with measured glucose disposal rate (GDR) from 104 clamp studies.<\/jats:p>\n Methods: We prepared an online tool for calculating IS using 17 formulae. Suitable formula(e) are suggested based on available (clinical and research) data. We also compare calculated IS with measured IS (GDR) from clamp studies in 104 adults with T1D (mean\u00b1SD) age 34\u00b17 yrs, T1D duration 10\u00b14 yrs, HbA1c 7.7\u00b11.5%, 33 with microvascular complications). Logistic regression was used to infer probability of calculated IS being below GDR=4.45 mg\/kg\/min or above GDR=6.5 mg\/kg\/min, which represent respectively the median and 75th percentile of measured GDR values.<\/jats:p>\n Results: A calculator is available at www.bit.ly\/estimated-GDR and an example result in the Figure 1. Estimated IS varied widely, but results interpretation is generally consistent.<\/jats:p>\n Conclusion: We developed an interactive tool to estimate IS in T1D for clinical and research use.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n A.S.Januszewski: None. P.Niedzwiecki: None. N.Sachithanandan: None. G.M.Ward: None. D.N.O'neal: None. D.Zozulinska-ziolkiewicz: Advisory Panel; Abbott, Lilly, Lilly, Novo Nordisk, Medtronic, Speaker's Bureau; Abbott, Ascensia Diabetes Care, Novo Nordisk, Medtronic, Boehringer-Ingelheim, AstraZeneca. A.Uruska: Other Relationship; Lilly, Boehringer-Ingelheim, AstraZeneca, Ascensia Diabetes Care, Sanofi. A.Jenkins: Advisory Panel; Insulet Corporation, Board Member; Insulin for Life, Research Support; Abbott Diabetes, Medtronic, Hemsley Charitable Trust, Juvenile Diabetes Research Foundation (JDRF), National Institutes of Health.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-1517-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:28:48Z","timestamp":1687238928000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1517-P: Interactive Calculator to Estimate Insulin Sensitivity (IS) in Type 1 Diabetes"],"prefix":"10.2337","volume":"72","author":[{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"first","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, FItzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAWEL","family":"NIEDZWIECKI","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, FItzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NIRUPA","family":"SACHITHANANDAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, FItzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GLENN M.","family":"WARD","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, FItzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, FItzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DOROTA","family":"ZOZULINSKA-ZIOLKIEWICZ","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, FItzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALEKSANDRA","family":"URUSKA","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, FItzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Poznan, Poland, FItzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1517-P\/149619\/1517-P-Interactive-Calculator-to-Estimate-Insulin","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1517-P\/149619\/1517-P-Interactive-Calculator-to-Estimate-Insulin","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:28:49Z","timestamp":1687238929000},"score":7.6428933,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1517-P\/149619\/1517-P-Interactive-Calculator-to-Estimate-Insulin"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-1517-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"1517-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:10:37Z","timestamp":1753884637269,"version":"3.41.2"},"reference-count":0,"publisher":"Environmental Health Perspectives","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISEE Conference Abstracts"],"published-print":{"date-parts":[[2022,9,18]]},"DOI":"10.1289\/isee.2022.p-0176","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T18:15:37Z","timestamp":1673979337000},"source":"Crossref","is-referenced-by-count":0,"title":["Long-term exposure to low level air pollution and the relationship with lung and bladder cancer in older men, in Perth, Western Australia"],"prefix":"10.1289","volume":"2022","author":[{"given":"Elizabeth","family":"Lim","sequence":"first","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Franklin","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Trevenen","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Heyworth","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"252","container-title":["ISEE Conference Abstracts"],"language":"en","link":[{"URL":"https:\/\/ehp.niehs.nih.gov\/doi\/10.1289\/isee.2022.P-0176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T19:45:49Z","timestamp":1717789549000},"score":7.642697,"resource":{"primary":{"URL":"https:\/\/ehp.niehs.nih.gov\/doi\/10.1289\/isee.2022.P-0176"}},"issued":{"date-parts":[[2022,9,18]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,9,18]]}},"alternative-id":["10.1289\/isee.2022.P-0176"],"URL":"https:\/\/doi.org\/10.1289\/isee.2022.p-0176","ISSN":["1078-0475"],"issn-type":[{"type":"print","value":"1078-0475"}],"published":{"date-parts":[[2022,9,18]]},"article-number":"isee.2022.P-0176"},{"indexed":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T01:20:37Z","timestamp":1711156837513},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"6_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,3,22]]},"abstract":"Abstract<\/jats:title>\n Background: Identifying patients at high risk for metachronous colorectal cancer metastasis is essential for improving prognosis. The balance between host immune regulation and tumor immune evasion ultimately permits or prevents cancer progression. Lymphocytic infiltration in colorectal cancer can predict long-term clinical outcomes. However, these lymphocytes' origin, subtype and function have yet to be adequately explored. We investigated the association between the development of metastasis and CD8+T cells expressing the integrin protein CD103, a marker of tissue-resident memory T cells.<\/jats:p>\n Methods: In this retrospective, case-control matched study, we conducted multiplex immunofluorescence staining of tumor samples from 124 patients with colorectal cancer. Tissue microarrays containing representative cores of the central tumor, invasive margin, and adjacent normal tissue were immunostained for CD3, CD8, CD103, pSMAD3, and cytokeratin, using tyramide signal amplification. Cells were quantified using StrataQuest digital image analysis software, with intratumoral and stromal regions analyzed separately. Kruskal-Wallis one-way analysis of variance with subsequent Dunn\u2019s test for pair-wise comparisons was performed using the Bonferroni method of multiple-comparison correction.<\/jats:p>\n Results: Central tumor and invasive margin CD3+ densities were associated with synchronous metastasis. Compared to non-metastatic patients, those who went on to develop metachronous metastasis (n=42) had a low proportion of intra-epithelial CD8+CD103+ T cells at the central tumor (non-metastatic: 32.8%, IQR 15.0-42.7%; metachronous metastasis: 12.9%, IQR 2.08-28.4%; P = 0.013). Similarly, patients with metachronous metastasis had a low proportion of stromal CD8+CD103+ T cells at the invasive margin (non-metastatic: 3.51%, IQR 1.83-6.55%; metachronous metastasis: 1.75%, IQR 0.62-3.72%; P = 0.019). On multivariate Cox regression of histological features, amongst patients with metastasis, significant overall survival prognostic markers<\/jats:p>\n included a low proportional CD8+CD103+ T cell infiltration (HR 2.41, 95%CI 1.16-5.01, P = 0.019), mucinous features (HR 4.28, 95%CI 1.98-9.24, P &lt; 0.001), and the presence of perineural invasion (HR 2.75, 95%CI 1.28-5.89, P &lt; 0.001).<\/jats:p>\n Conclusion: CD8+CD103+ lymphocytes may protect from the development of colorectal metastasis. Proportional CD8+CD103+ T cell infiltration is a promising prognostic marker in colorectal adenocarcinoma for the development of metachronous metastasis, and, amongst patients with metastasis, it is a prognostic marker of overall survival.<\/jats:p>\n Citation Format: Ryan Cohen, Tracey Lee-Pullen, Timothy Miller, Shadi Pirasteh, Cameron Platell, Katie Meehan, Kathy Fuller, Melanie McCoy. Tissue-resident cytotoxic T cell infiltration predicts metachronous colorectal cancer metastasis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5525.<\/jats:p>","DOI":"10.1158\/1538-7445.am2024-5525","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T11:59:45Z","timestamp":1711108785000},"page":"5525-5525","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 5525: Tissue-resident cytotoxic T cell infiltration predicts metachronous colorectal cancer metastasis"],"prefix":"10.1158","volume":"84","author":[{"given":"Ryan","family":"Cohen","sequence":"first","affiliation":[{"name":"1University of Western Australia, Perth, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracey","family":"Lee-Pullen","sequence":"additional","affiliation":[{"name":"1University of Western Australia, Perth, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Miller","sequence":"additional","affiliation":[{"name":"1University of Western Australia, Perth, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadi","family":"Pirasteh","sequence":"additional","affiliation":[{"name":"2Western Diagnostic Pathology, Perth, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron","family":"Platell","sequence":"additional","affiliation":[{"name":"1University of Western Australia, Perth, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Meehan","sequence":"additional","affiliation":[{"name":"1University of Western Australia, Perth, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Fuller","sequence":"additional","affiliation":[{"name":"1University of Western Australia, Perth, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"McCoy","sequence":"additional","affiliation":[{"name":"1University of Western Australia, Perth, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/84\/6_Supplement\/5525\/740994\/Abstract-5525-Tissue-resident-cytotoxic-T-cell","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/84\/6_Supplement\/5525\/740994\/Abstract-5525-Tissue-resident-cytotoxic-T-cell","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T11:59:45Z","timestamp":1711108785000},"score":7.642653,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/84\/6_Supplement\/5525\/740994\/Abstract-5525-Tissue-resident-cytotoxic-T-cell"}},"issued":{"date-parts":[[2024,3,22]]},"references-count":0,"journal-issue":{"issue":"6_Supplement","published-print":{"date-parts":[[2024,3,22]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2024-5525","ISSN":["1538-7445"],"issn-type":[{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2024,3,22]]}},{"indexed":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T05:15:19Z","timestamp":1678511719704},"reference-count":0,"publisher":"Ovid 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Urology"],"language":"en","link":[{"URL":"http:\/\/www.auajournals.org\/doi\/pdf\/10.1097\/01.JU.0000557377.92423.45","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T16:52:13Z","timestamp":1678467133000},"score":7.6423526,"resource":{"primary":{"URL":"http:\/\/www.auajournals.org\/doi\/10.1097\/01.JU.0000557377.92423.45"}},"issued":{"date-parts":[[2019,4]]},"references-count":0,"journal-issue":{"issue":"Supplement 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Pain summation, time taken and the number of protective behaviours with repeated bending were measured. Sensory tests included two\u2010point discrimination, temporal summation, pressure\/thermal pain thresholds and conditioned pain modulation. Subgroups were profiled against movement and sensory variables.<\/jats:p><\/jats:sec>Results<\/jats:title>The high\u2010risk subgroup demonstrated greater pain summation following repeated forward bending (p\u00a0<\/jats:italic><\u00a00.001). The medium\u2010risk subgroup demonstrated greater pain summation following repeated backward bending (p\u00a0<\/jats:italic>=\u00a00.032). Medium\u2010 and high\u2010risk subgroups demonstrated greater forward\/backward bend time compared to the low\u2010risk subgroup (p\u00a0<\/jats:italic>=\u00a00.001, p\u00a0<\/jats:italic>=\u00a00.005, respectively). Medium\u2010 and high\u2010risk subgroups demonstrated a higher number of protective behaviours per forward bend compared to the low\u2010risk subgroup (p\u00a0<\/jats:italic>=\u00a00.008). For sensory variables, only two\u2010point discrimination differed between subgroups, with medium\u2010 and high\u2010risk subgroups demonstrating higher thresholds (p\u00a0<\/jats:italic>=\u00a00.016).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This study showed altered movement characteristics and sensory discrimination across SBT risk subgroups in people with CLBP. Membership of the high SBT risk subgroup was associated with greater pain and disability levels, greater pain summation following repeated bending, slower bending times, a greater number of protective behaviours during forward bending, and a higher TPD threshold. Treatment outcomes for higher risk SBT subgroups may be enhanced by interventions specifically targeting movement and sensory alterations.<\/jats:p><\/jats:sec>Significance<\/jats:title>In 290 people with chronic low back pain movement profile and two\u2010point discrimination threshold differed across risk subgroups defined by the STarT Back Tool. Conversely, pain sensitivity did not differ across these subgroups. These findings may add further guidance for targeted care in these subgroups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1351","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T17:41:32Z","timestamp":1545673292000},"page":"823-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["STarT Back Tool risk stratification is associated with changes in movement profile and sensory discrimination in low back pain: A study of 290 patients"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3814-909X","authenticated-orcid":false,"given":"Martin","family":"Rabey","sequence":"first","affiliation":[{"name":"Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Kendell","sequence":"additional","affiliation":[{"name":"Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Godden","sequence":"additional","affiliation":[{"name":"Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jermaine","family":"Liburd","sequence":"additional","affiliation":[{"name":"Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Netley","sequence":"additional","affiliation":[{"name":"Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciaran","family":"O\u2019Shaughnessy","sequence":"additional","affiliation":[{"name":"Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Smith","sequence":"additional","affiliation":[{"name":"Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Beales","sequence":"additional","affiliation":[{"name":"Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,11]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Australian Bureau of Statistics(2013).1220.0 \u2010 ANZSCO \u2013 Australian and New Zealand Standard Classification of Occupations 2013 Version 1.2 2013. 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This study investigates the clinical and functional relevance of dyskerin expression in the paediatric cancer neuroblastoma. Here it is shown, in two independent neuroblastoma patient cohorts, that high expression of the gene encoding dyskerin (DKC1) very strongly correlates with poor event-free and overall survival. The prognostic power of DKC1 expression was independent of the established indicators used in the management of this disease, namely diagnosis age &gt; 1.5 yr, stage of disease and amplification of the MYCN oncogene (P&lt;0.0001). Dyskerin mRNA and protein expression were also found to be elevated, relative to normal cells, across a panel of neuroblastoma cell lines. Chromatin immunoprecipitation showed that the DKC1 promoter region was directly targeted by both MycN and c-Myc in neuroblastoma cells. Depletion of dyskerin using RNAi severely impaired proliferation, inhibited anchorage independent growth and dramatically slowed tumour growth in a mouse model of neuroblastoma (P&lt;0.01, Two-way Anova). In p53 competent cells, the proliferative arrest induced by dyskerin depletion was accompanied by an accumulation of p53 and p21cip1, accumulation in G1 phase of the cell cycle and cell death. However in the absence of p53 function, an alternate mechanism operated to impair proliferation when dyskerin was downregulated. The mechanism responsible for the proliferative arrest also appeared to be telomerase-independent, as it was not rescued by ectopic overexpression of telomerase. Taken together, these data identify DKC1 is a crucial MYC target gene in neuroblastoma, and show that neuroblastoma cells become addicted to high DKC1 expression. The results support further investigation of DKC1 as a therapeutic target in the treatment of refractory neuroblastoma.<\/jats:p>\n Citation Format: Rosemary O'Brien, Michelle F. Maritz, Cheng Fei Kong, Stefania Purgato, Bing Liu, Chen Yang, Amanda Russell, Jayne Murray, Claudia Flemming, Michelle Haber, Giovanni Perini, Murray D. Norris, Jamie I. Fletcher, Karen L. Mackenzie. High DKC1 expression supports neuroblastoma tumor cell proliferation and is strongly associated with poor patient outcomes. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. 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Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng Fei","family":"Kong","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Purgato","sequence":"additional","affiliation":[{"name":"2University of Bologna, Bologna, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Russell","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, 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Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie I.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L.","family":"Mackenzie","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/75\/15_Supplement\/488\/604044\/Abstract-488-High-DKC1-expression-supports","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/75\/15_Supplement\/488\/604044\/Abstract-488-High-DKC1-expression-supports","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T23:44:45Z","timestamp":1656373485000},"score":7.642035,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/75\/15_Supplement\/488\/604044\/Abstract-488-High-DKC1-expression-supports"}},"issued":{"date-parts":[[2015,8,1]]},"references-count":0,"journal-issue":{"issue":"15_Supplement","published-print":{"date-parts":[[2015,8,1]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2015-488","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2015,8,1]]}},{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:21:11Z","timestamp":1787829671186,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To inform in\u2010event health service (IEHS) delivery and harm minimisation strategies for the planned youth mass gathering event (MGE) known as \u2018Leavers\u2019 in the Southwest region of Western Australia. This study aimed to describe patient emergency department (ED) presentation characteristics and outcomes for Leavers WA.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective observational study of patient presentations by Leavers to the Busselton ED at the 2022 MGE. This included 4\u2009days with IEHS operation (7\u2009pm to 1\u2009am), 2\u2009days prior to and 3\u2009days post the MGE. Data analysis included descriptive and inferential statistics.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 9621 Leavers, 121 (1.26%, PPR 12.6\/1000) presented to ED: 12 prior to, 85 during and 24 post the MGE. The majority of presentations were from the community (\n n<\/jats:italic>\n \u2009=\u2009103, 85.1%). Of 557 Leavers who presented to the IEHS, 18 were transported to hospital (TTHR 1.87\/1000). The majority of presentations were ATS 3 and ATS 4 (43.8%, 42.1%). Medical illness was the most common presentation category (\n n<\/jats:italic>\n \u2009=\u200959, 48.8%). 51.2% of presentations were related to alcohol\/illicit substance use. 85.6% of Leavers were seen and allocated a discharge disposition within 4\u2009h.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Leavers WA celebrations introduced a significant burden on the regional ED with over half the presentations drug and alcohol related and the majority of patients requiring urgent or semi\u2010urgent assessment. The IEHS likely reduced this burden during operational hours. Future research should focus on standardisation of data collection, comparing IEHS and ED presentations, and measuring effectiveness of harm minimisation strategies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1742-6723.70308","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T08:36:06Z","timestamp":1786696566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emergency Department Presentations During Southwest Leavers Week 2022: A Retrospective Observational Study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6676-5642","authenticated-orcid":false,"given":"James","family":"Borshoff","sequence":"first","affiliation":[{"name":"The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siena","family":"McQuillan","sequence":"additional","affiliation":[{"name":"The University of Western Australia Crawley Western Australia Australia"},{"name":"Western Australian Country Health Service Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Jamieson","sequence":"additional","affiliation":[{"name":"The University of Western Australia Crawley Western Australia Australia"},{"name":"The Rural Clinical School of Western Australia Bunbury Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Willix","sequence":"additional","affiliation":[{"name":"The University of Western Australia Crawley Western Australia Australia"},{"name":"Western Australian Country Health Service Perth Western Australia Australia"},{"name":"The Rural Clinical School of Western Australia Bunbury Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"\u201cEmergencies: WHO's Role in Mass Gatherings \u201dhttps:\/\/www.who.int\/news\u2010room\/questions\u2010and\u2010answers\/item\/what\u2010is\u2010who\u2010s\u2010role\u2010in\u2010mass\u2010gatherings."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1049023X14001216"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1049023X00004507"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09595239996419"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u2010842x.1997.tb01679.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753\u20106405.12266"},{"issue":"1","key":"e_1_2_11_8_1","first-page":"26","article-title":"Schoolies Week in Perspective; Studies of Alcohol, Drug and Risk\u2010Taking Behaviour","volume":"3","author":"Salom C.","year":"2005","journal-title":"Of Substance. The National Magazine of ATOR"},{"key":"e_1_2_11_9_1","volume-title":"School Leavers' Celebrations on Rottnest Island: Formative Evaluation Report","author":"Bogaards T.","year":"2000"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742\u20106723.13399"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-6405.12324"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdt087"},{"key":"e_1_2_11_13_1","unstructured":"City of Busselton City Profile(City of Busselton 2024) accessed June 13 2026 https:\/\/www.busselton.wa.gov.au\/discover\/about\u2010the\u2010city\/city\u2010profile.aspx."},{"key":"e_1_2_11_14_1","unstructured":"Busselton Health Campus \u201cAustralian Institute of Health and Welfare 2023 \u201daccessed May 19 2024 https:\/\/www.aihw.gov.au\/reports\u2010data\/myhospitals\/hospital\/h0703."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare10091625"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1049023X1800078X"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1049023X15004598"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1049023X12000271"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1049023X00025905"},{"key":"e_1_2_11_20_1","unstructured":"\u201cRoad Statistics: South West 2023 \u201daccessed May 21 2023 https:\/\/www.wa.gov.au\/organisation\/road\u2010safety\u2010commission\/road\u2010statistics\u2010south\u2010west."},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13033\u2010020\u201000356\u20109"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.7453\/gahmj.2013.045"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0022\u20103514.69.3.505"},{"key":"e_1_2_11_24_1","unstructured":"\u201cWA Emergency Access Target \u201daccessed May 21 2024 https:\/\/www.health.wa.gov.au\/Improving\u2010WA\u2010Health\/Emergency\u2010access\u2010reform%23:~:text=The%20WEAT%20requires%20that%2090."},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0196\u20100644(96)70264\u20100"}],"container-title":["Emergency Medicine Australasia"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1742-6723.70308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1742-6723.70308","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1742-6723.70308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:48:10Z","timestamp":1787827690000},"score":7.6413665,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1742-6723.70308"}},"issued":{"date-parts":[[2026,8]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/1742-6723.70308"],"URL":"https:\/\/doi.org\/10.1111\/1742-6723.70308","archive":["Portico"],"ISSN":["1742-6731","1742-6723"],"issn-type":[{"value":"1742-6731","type":"print"},{"value":"1742-6723","type":"electronic"}],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70308"},{"indexed":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:20:21Z","timestamp":1716942021297},"reference-count":0,"publisher":"World Scientific Pub Co Pte Ltd","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FandR"],"published-print":{"date-parts":[[2023,12]]},"abstract":" Background and Aims: IVF responses to gonadotrophins may be difficult to predict in patients with PCOS. Nowadays there are various options including using the strategy of GnRH agonist trigger and freeze all embryos. The follitropin delta dosing algorithm has been used to predict an ovarian response that reduces the effects of ovarian hyperstimulation syndrome. The aim of this study was to compare the outcomes of three different FSH dosing strategies in PCOS patients. <\/jats:p> Methods: This retrospective multi-centre trial enrolled 626 PCOS women. They underwent 855 stimulated IVF cycles using a GnRH antagonist protocol and 634 frozen embryo transfers with embryos from the original stimulated cycles. <\/jats:p> Patients were classified into 3 groups: Group 1 (underdosing), Group 2 (algorithm dosing) and group 3 (overdosing). The algorithmic dose was based on the follitropin delta algorithm using AMH and body weight. The main outcome measure was the live birth rate per cycle started. <\/jats:p> Results: The live birth rate per cycle was 40.8% for group 1, 42.1% for group 2 and 45.5% for group 3. Group 3 had the greatest average number of embryos frozen (1.55 embryos in group 1, 2.45 group 2 and 2.96 group 3). The average number of eggs collected was greatest in group 3 (8.7 eggs in group 1, 11.9 group 2 and 14.2 group 3). The most frozen of all cycles occurred in group 3 (45.6%). <\/jats:p> Conclusions: Higher FSH dosing resulted in more eggs and more live births per cycle started. It also resulted in less fresh embryo transfers. These results could be used when choosing an FSH dosing strategy for PCOS patients. <\/jats:p>","DOI":"10.1142\/s266131822374331x","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T05:50:40Z","timestamp":1706593840000},"page":"594-594","source":"Crossref","is-referenced-by-count":0,"title":["#325 : A Comparison of Three Different IVF FSH Dosing Strategies for PCOS Patients; A Retrospective Analysis of 855 IVF Cycles"],"prefix":"10.1142","volume":"05","author":[{"given":"Robert","family":"Lahoud","sequence":"first","affiliation":[{"name":"IVF Australia, Greenwich, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Venetis","sequence":"additional","affiliation":[{"name":"IVF Australia, Greenwich, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kath","family":"Whitton","sequence":"additional","affiliation":[{"name":"IVF Australia, Greenwich, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franca","family":"Agresta","sequence":"additional","affiliation":[{"name":"IVF Australia, Greenwich, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2024,1,26]]},"container-title":["Fertility & Reproduction"],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S266131822374331X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T03:30:25Z","timestamp":1716867025000},"score":7.6413655,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/10.1142\/S266131822374331X"}},"issued":{"date-parts":[[2023,12]]},"references-count":0,"journal-issue":{"issue":"04","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1142\/S266131822374331X"],"URL":"https:\/\/doi.org\/10.1142\/s266131822374331x","ISSN":["2661-3182","2661-3174"],"issn-type":[{"value":"2661-3182","type":"print"},{"value":"2661-3174","type":"electronic"}],"published":{"date-parts":[[2023,12]]}},{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:09:49Z","timestamp":1770743389214,"version":"3.49.0"},"reference-count":35,"publisher":"Association for Computing Machinery (ACM)","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"funder":[{"DOI":"10.13039\/501100000943","name":"Commonwealth Scientific and Industrial Research Organisation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000943","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":["ACM Trans. Sen. Netw."],"published-print":{"date-parts":[[2014,1]]},"abstract":"Radio connectivity in wireless sensor networks is highly intermittent due to unpredictable and time-varying noise and interference patterns in the environment. Because link qualities are not predictable prior to deployment, current deterministic solutions to unreliable links, such as increasing network density or transmission power, require overprovisioning of network resources and do not always improve reliability.<\/jats:p>\n We propose a new dual-radio network architecture to improve communication reliability in wireless sensor networks. Specifically, we show that radio transceivers operating at well-separated frequencies and spatially separated antennas offer robust communication, high link diversity, and better interference mitigation. We derive the optimal parameters for the dual-transceiver setup from frequency and space diversity in theory. We observe that frequency diversity holds the most benefits as long as the antennas are sufficiently separated to prevent coupling. Our experiments on an indoor\/outdoor testbed confirm the theoretical predictions and show that radio diversity can significantly improve end-to-end delivery rates and network stability at only a small increase in energy cost over a single radio. Simulation experiments further validate the improvements in multiple topology configurations, but also reveal that the benefits of radio diversity are coupled to the number of available routing paths to the destination.<\/jats:p>","DOI":"10.1145\/2530291","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T13:49:22Z","timestamp":1390916962000},"page":"1-29","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Radio diversity for reliable communication in sensor networks"],"prefix":"10.1145","volume":"10","author":[{"given":"Branislav","family":"Kusy","sequence":"first","affiliation":[{"name":"CSIRO, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Abbott","sequence":"additional","affiliation":[{"name":"CSIRO, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Richter","sequence":"additional","affiliation":[{"name":"CSIRO, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Huynh","sequence":"additional","affiliation":[{"name":"CSIRO, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Afanasyev","sequence":"additional","affiliation":[{"name":"CSIRO, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Hu","sequence":"additional","affiliation":[{"name":"CSIRO, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Br\u00fcnig","sequence":"additional","affiliation":[{"name":"CSIRO, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diethelm","family":"Ostry","sequence":"additional","affiliation":[{"name":"CSIRO, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Jurdak","sequence":"additional","affiliation":[{"name":"CSIRO, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"320","published-online":{"date-parts":[[2014,1,31]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1504\/IJSNET.2010.034066"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1145\/1039111.1039122"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1145\/1023720.1023732"},{"key":"e_1_2_1_4_1","volume-title":"Proceedings of the 6th Workshop on Hot Topics in Networks (HotNets'07)","author":"Fonseca Rodrigo","year":"2007","unstructured":"Rodrigo Fonseca , Omprakash Gnawali , Kyle Jamieson , and Philip Levis . 2007 . Four-bit wireless link estimation . In Proceedings of the 6th Workshop on Hot Topics in Networks (HotNets'07) . http:\/\/conferences.sigcomm.org\/hotnets\/2007\/papers\/hotnets6-final131.pdf. Rodrigo Fonseca, Omprakash Gnawali, Kyle Jamieson, and Philip Levis. 2007. Four-bit wireless link estimation. In Proceedings of the 6th Workshop on Hot Topics in Networks (HotNets'07). http:\/\/conferences.sigcomm.org\/hotnets\/2007\/papers\/hotnets6-final131.pdf."},{"key":"e_1_2_1_5_1","unstructured":"Omprakash Gnawali. 2010. TEP 124: The link estimation exchange protocol. http:\/\/www.tinyos.net\/tinyos2.x\/doc\/. Omprakash Gnawali. 2010. TEP 124: The link estimation exchange protocol. http:\/\/www.tinyos.net\/tinyos2.x\/doc\/."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1145\/1644038.1644040"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1109\/INFCOM.2009.5061917"},{"key":"e_1_2_1_8_1","unstructured":"Vlado Handziski Joseph Polastre Jan Hauer Cory Sharp Adam Wolisz David Culler and David Gay. 2010. TEP 2: Hardware abstraction architecture. http:\/\/www.tinyos.net\/tinyos-2.x\/doc\/. Vlado Handziski Joseph Polastre Jan Hauer Cory Sharp Adam Wolisz David Culler and David Gay. 2010. TEP 2: Hardware abstraction architecture. http:\/\/www.tinyos.net\/tinyos-2.x\/doc\/."},{"key":"e_1_2_1_9_1","volume-title":"Phased Array Antennas","author":"Hansen Robert C.","unstructured":"Robert C. Hansen . 2009. Phased Array Antennas . Wiley-Interscience . Robert C. Hansen. 2009. Phased Array Antennas. 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Although it is known that elimination of hypoglycemia can restore hypoglycemia awareness in this high-risk group, this has been challenging in real life. Technological advancements like closed loop system provide an opportunity to minimize hypoglycemia. Hence, the aim of this study was to evaluate whether a hybrid closed loop insulin delivery system can improve hypoglycemia awareness in individuals with IAH.<\/jats:p>\n Methods: Participants with type 1 diabetes and IAH (Gold Score \u22654) were randomized to either a hybrid closed loop system (Medtronic 670G) (intervention) or standard insulin pump therapy (control) for 8 weeks. Gold scores and hyperinsulinemic hypoglycemic clamp studies were undertaken at baseline and at the end of the study with evaluation of the hormonal and symptomatic responses to hypoglycemia.<\/jats:p>\n Results: A total of 17 participants completed the study (mean (SD) age 35.8 years (11.2), diabetes duration 24.2 years (11.3), HbA1c 7.8% (1.2)). 8 participants were randomized to control and 9 participants to intervention. The baseline (Median, IQR) Gold score was 6.0 (5.0; 6.0) in the overall cohort and did not differ between groups. At the study end, Gold score improved in the intervention group: control vs. intervention 6.0 (4.5; 6.0) vs. 3.5 (3.0; 4.5); p = 0.027. Symptom scores (adrenergic and neuroglycopenic) during the clamp were not different between the control and intervention groups.<\/jats:p>\n Conclusions: The use of a hybrid closed loop system over 8 weeks improved self-reported hypoglycemia awareness, however there was no evidence for improvement in the symptomatic responses to experimentally induced hypoglycemia.<\/jats:p>\n \n Disclosure<\/jats:title>\n M. Burckhardt: None. J. Dart: None. G.J. Smith: None. M.B. Abraham: None. N. Paramalingam: None. J.M. O'Dea: None. M. de Bock: None. E.A. Davis: None. T. Jones: Research Support; Self; Dexcom, Inc., Medtronic MiniMed, Inc. Speaker's Bureau; Self; Eli Lilly and Company, Roche Diabetes Care.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-282-or","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T02:41:27Z","timestamp":1559702487000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["282-OR: Impact of a Hybrid Closed-Loop Insulin Delivery System on Hypoglycemia Awareness in Individuals with Type 1 Diabetes"],"prefix":"10.2337","volume":"68","author":[{"given":"MARIE-ANNE","family":"BURCKHARDT","sequence":"first","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JULIE","family":"DART","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GRANT J.","family":"SMITH","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARY B.","family":"ABRAHAM","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NIRUBASINI","family":"PARAMALINGAM","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOANNE M.","family":"O'DEA","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTIN DE","family":"BOCK","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIZABETH A.","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIMOTHY","family":"JONES","sequence":"additional","affiliation":[{"name":"Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/282-OR\/60538\/282-OR-Impact-of-a-Hybrid-Closed-Loop-Insulin","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/282-OR\/60538\/282-OR-Impact-of-a-Hybrid-Closed-Loop-Insulin","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:13:07Z","timestamp":1647166387000},"score":7.6411605,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/282-OR\/60538\/282-OR-Impact-of-a-Hybrid-Closed-Loop-Insulin"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-282-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"282-OR"},{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:06:57Z","timestamp":1769083617094,"version":"3.49.0"},"reference-count":97,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2022,9]]},"abstract":"Summary<\/jats:title>Previous preclinical and clinical trials have shown promising antitumour activity and toxicity profile when employing the \u2018Synergy between Immunotherapy and Radiotherapy\u2019 (SITAR) strategy. Approximately, one in seven radiation therapy studies currently recruiting is investigating SITAR. This article reviews the range of cancers known to respond to immunotherapy and publications analysing SITAR. It sets the background for work that needs to be done in future clinical trials. It also reviews the potential toxicities of immunotherapy and discusses areas where caution is required when combining treatments.<\/jats:p>","DOI":"10.1111\/1754-9485.13441","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T12:04:25Z","timestamp":1655208265000},"page":"881-895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical evidence for synergy between immunotherapy and radiotherapy (SITAR<\/scp>)"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-7232","authenticated-orcid":false,"given":"Suki","family":"Gill","sequence":"first","affiliation":[{"name":"Sir Charles Gairdner Hospital Nedlands Western Australia Australia"},{"name":"University of Western Australia Crawley Western Australia 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Of these, the Blacktip gas field has been in production since 2009, while additional gas resources are under consideration for development. The sedimentary succession extends across the Permian\u2013Triassic stratigraphic boundary, and shows a change in lithofacies from the carbonate dominated Dombey Formation to the siliciclastic dominated Tern and Penguin formations. The timing, duration, distribution and depositional environments of these formations in the Petrel Sub-basin and Londonderry High is the focus of this study. The sedimentary succession extending from the Dombey to the Penguin formations is interpreted to represent marginal marine facies which accumulated during a long-lasting marine transgression that extended over previous coastal and alluvial plain sediments of the Cape Hay Formation. The overlying Mairmull Formation represents the transition to fully marine deposition in the Early Triassic. Regional scale well correlations and an assessment of biostratigraphic data indicate that marginal marine depositional systems were initiated outboard before the end-Permian extinction event, and migrated inboard at about the Permian\u2013Triassic stratigraphic boundary. Marginal marine deposition across the southern Bonaparte Basin continued through the faunal and floral recovery phase as Triassic species became established. The depositional history of the basin is translated to a chronostratigraphic framework which has implications for predicting the character and distribution of petroleum system elements in the Petrel Sub-basin and Londonderry High.<\/jats:p>","DOI":"10.1071\/aj20111","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T02:22:09Z","timestamp":1625192529000},"page":"699-706","source":"Crossref","is-referenced-by-count":0,"title":["Late Permian\u2013Early Triassic depositional history in the southern Bonaparte Basin: new biostratigraphic insights into reservoir heterogeneity"],"prefix":"10.1071","volume":"61","author":[{"given":"R.","family":"Owens","sequence":"first","affiliation":[{"name":"AGeoscience Australia, Canberra, Australia."},{"name":"BCorresponding author. 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While diagnostic and prognostic scores exist, artificial intelligence (AI) may be able to assist with these tasks.<\/jats:p><\/jats:sec>Method<\/jats:title>A systematic review was conducted aiming to evaluate the currently available evidence regarding the use of AI in the diagnosis and prognostication of paediatric appendicitis. In accordance with the PRISMA guidelines, the databases PubMed, EMBASE, and Cochrane Library were searched. This review was prospectively registered on PROSPERO.<\/jats:p><\/jats:sec>Results<\/jats:title>Ten studies met inclusion criteria. All studies described the derivation and validation of AI models, and none described evaluation of the implementation of these models. Commonly used input parameters included varying combinations of demographic, clinical, laboratory, and imaging characteristics. While multiple studies used histopathological examination as the ground truth for a diagnosis of appendicitis, less robust techniques, such as the use of ICD10 codes, were also employed. Commonly used algorithms have included random forest models and artificial neural networks. High levels of model performance have been described for diagnosis of appendicitis and, to a lesser extent, subtypes of appendicitis (such as complicated versus uncomplicated appendicitis). Most studies did not provide all measures of model performance required to assess clinical usability.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The available evidence suggests the creation of prediction models for diagnosis and classification of appendicitis using AI techniques, is being increasingly explored. However, further implementation studies are required to demonstrate benefit in system or patient\u2010centred outcomes with model deployment and to progress these models to the stage of clinical usability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18610","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T10:29:13Z","timestamp":1689589753000},"page":"2070-2078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Artificial intelligence for predicting acute appendicitis: a systematic review"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2735-762X","authenticated-orcid":false,"given":"Antoinette","family":"Lam","sequence":"first","affiliation":[{"name":"University of Adelaide Adelaide South Australia 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The purpose of this research is to identify behaviour change techniques in a food literacy program, which were assessed by the achievement of participant goals related to food literacy and dietary behaviour changes.<\/jats:p><\/jats:sec>Methods<\/jats:title>Consensus methods were applied to map behaviour change techniques to an adult food literacy program. A second phase investigation applied content analysis of participant process evaluation data (collected between 2016 and June 2021) to align target behaviours and behaviour change techniques. Chi\u2010square and ANCOVA were used to assess the statistically significant demographic characteristics, food literacy, and dietary behaviour scores for participants who set goals and recorded changes.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 4697 program participants provided evaluation data from the 4\u2010week food literacy program. Participants who set goals and made changes were statistically more likely to have higher food literacy factor scores (p<\/jats:italic>\u2009<\u20090.001) and fruit serves (p<\/jats:italic>\u2009=\u20090.004). Statistical analysis showed that participants were more likely to have set goals and recorded changes if they were female (p<\/jats:italic>\u2009<\u20090.001), older (p<\/jats:italic>\u2009<\u20090.001), higher education level (p<\/jats:italic>\u2009<\u20090.001), had a higher socioeconomic status (p<\/jats:italic>\u2009=\u20090.049), lived with children (p<\/jats:italic>\u2009=\u20090.014), were born in Australia (p<\/jats:italic>\u2009=\u20090.019), or did not identify as Indigenous (p<\/jats:italic>\u2009<\u20090.001). The behaviour change technique mapping process identified nine techniques used weekly and a total of 22 techniques used over the entire 4 week program curriculum.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This is the first Australian study to link the contribution of behaviour change techniques to food literacy and dietary behaviour change in an established effective food literacy program. Knowing the behaviour change techniques associated with effective programs will facilitate replication of effective interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1747-0080.12908","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T08:43:08Z","timestamp":1729586588000},"page":"268-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysing the behaviour change techniques in an effective food literacy program to inform future program design"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-3281","authenticated-orcid":false,"given":"Lucy M.","family":"Butcher","sequence":"first","affiliation":[{"name":"Edith Cowan University Joondalup Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caylah","family":"Batt","sequence":"additional","affiliation":[{"name":"Foodbank Western Australia Perth Airport Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2144-8976","authenticated-orcid":false,"given":"Sophie","family":"Royce","sequence":"additional","affiliation":[{"name":"Foodbank Western Australia Perth Airport Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eamon","family":"Barron","sequence":"additional","affiliation":[{"name":"Foodbank Western Australia Perth Airport Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9016-1251","authenticated-orcid":false,"given":"Roslyn","family":"Giglia","sequence":"additional","affiliation":[{"name":"Edith Cowan University Joondalup Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5448-8932","authenticated-orcid":false,"given":"Andrea","family":"Begley","sequence":"additional","affiliation":[{"name":"Curtin University Bentley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneb.2017.08.004"},{"key":"e_1_2_9_3_1","article-title":"Food skills education and low\u2010income adults' healthy food choices","author":"Pooler JA","year":"2021","journal-title":"Community Health Equity Res & 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Dietetics"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1747-0080.12908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:41:34Z","timestamp":1754916094000},"score":7.6396885,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1747-0080.12908"}},"issued":{"date-parts":[[2024,10,22]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/1747-0080.12908"],"URL":"https:\/\/doi.org\/10.1111\/1747-0080.12908","archive":["Portico"],"ISSN":["1446-6368","1747-0080"],"issn-type":[{"type":"print","value":"1446-6368"},{"type":"electronic","value":"1747-0080"}],"published":{"date-parts":[[2024,10,22]]},"assertion":[{"value":"2024-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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Council"},{"name":"Cancer Institute of New South Wales, and the Melanoma Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2015,11]]},"abstract":"BACKGROUND<\/jats:title>The degree of response and the duration of survival of patients treated with mitogen\u2010activated protein kinase (MAPK) inhibitors are highly variable. Whether baseline clinicopathologic factors can predict the clinical course with treatment is largely unknown.<\/jats:p><\/jats:sec>METHODS<\/jats:title>For 142 consecutive immunotherapy\u2010 and MAPK inhibitor\u2013naive patients with BRAF\u2010mutant metastatic melanoma who were treated during clinical trials with BRAF inhibitors (n = 111) or a combination of dabrafenib and trametinib (n = 31), clinicopathologic factors were correlated with the response to MAPK inhibitors and survival.<\/jats:p><\/jats:sec>RESULTS<\/jats:title>The median follow\u2010up was 15.7 months (range, 0.6\u201060.5 months). The 2\u2010, 3\u2010, and 4\u2010year overall survival (OS) rates were 43%, 24%, and 24%, respectively. A multivariate analysis demonstrated that the only clinicopathologic factors associated with longer progression\u2010free survival (PFS) and OS were female sex and a normal pretreatment serum lactate dehydrogenase (LDH) level. The BRAF V600E genotype and an absence of primary melanoma ulceration were also independently associated with longer PFS but not OS. The median OS was 23.5 months for patients with normal LDH levels and 7.3 months for those with elevated LDH levels (hazard ratio, 0.31; P<\/jats:italic> < .001). Complete responders had the best survival, but disease progression still occurred in 2 of 7 patients.<\/jats:p><\/jats:sec>CONCLUSIONS<\/jats:title>Long\u2010term survival occurs for a minority of patients receiving MAPK inhibitor treatment alone. Sex, serum LDH, BRAF genotype, and primary melanoma ulceration status are independent factors associated with treatment outcomes. Patients with a complete response to treatment have the best survival, but relapses still occur. Cancer<\/jats:italic> 2015;121:3826\u20133835.<\/jats:bold> \u00a9 2015 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.29586","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T10:12:04Z","timestamp":1438078324000},"page":"3826-3835","source":"Crossref","is-referenced-by-count":42,"title":["Clinicopathologic features associated with efficacy and long\u2010term survival in metastatic melanoma patients treated with BRAF<\/scp> or combined BRAF<\/scp> and MEK inhibitors"],"prefix":"10.1002","volume":"121","author":[{"given":"Alexander M.","family":"Menzies","sequence":"first","affiliation":[{"name":"Melanoma Institute Australia Sydney Australia"},{"name":"The University of Sydney Sydney Australia"},{"name":"Royal North Shore Hospital Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Wilmott","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia Sydney Australia"},{"name":"The University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Drummond","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia Sydney Australia"},{"name":"The University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serigne","family":"Lo","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia Sydney Australia"},{"name":"The University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Lyle","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia Sydney Australia"},{"name":"The University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew M. K.","family":"Chan","sequence":"additional","affiliation":[{"name":"Crown Princess Mary Cancer Centre Westmead Hospital Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia Sydney Australia"},{"name":"The University of Sydney Sydney Australia"},{"name":"Royal Prince Alfred Hospital Sydney Australia"},{"name":"Mater Hospital Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Guminski","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia Sydney Australia"},{"name":"The University of Sydney Sydney Australia"},{"name":"Royal North Shore Hospital Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo S.","family":"Carlino","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia Sydney Australia"},{"name":"The University of Sydney 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In addition, we wanted to understand whether there were any reported changes in that pain, and how and who delivered BA.<\/jats:p>\n <\/jats:sec>\n \n Eligibility criteria<\/jats:title>\n Primary research published in English.<\/jats:p>\n <\/jats:sec>\n \n Sources of evidence<\/jats:title>\n We searched seven databases MEDLINE, Ovid Embase, Ovid Emcare, PsycINFO, CINAHL, Scopus and Web of Science, for primary research. No initial date limit was used with the date the searches were conducted used as the end date limit (1 July 2021).<\/jats:p>\n <\/jats:sec>\n \n Charting methods<\/jats:title>\n A customised data extraction table was developed, piloted and used.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n 551 papers were screened for inclusion, with 15 papers included in our review. Studies were conducted in North America and in Canada. These included three case studies, nine uncontrolled trials and three randomised controlled trials. Only two studies reported pain as the primary outcome. BA was applied across a range of pain related conditions. The dose of BA ranged from 3 to 16 sessions. Duration of treatment was 3 weeks to 12 months. Most studies reported reductions in pain following exposure to BA.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n BA has the potential to reduce pain. Caution needs to be exercised in the interpretation of these findings as a high risk of bias was observed in most studies. 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To this end, many computational tools have been released and a plethora of bioinformatic approaches are used for eDNA\u2010based community composition analysis. Simulation studies and careful evaluation of taxonomic classifiers are essential to establish reliable benchmarks to improve the accuracy and reproducibility of eDNA\u2010based findings. Here we present a comprehensive evaluation of nine taxonomic classifiers exploring three widely used mitochondrial markers (12S rDNA, 16S rDNA and COI) in Australian marine vertebrates. Curated reference databases and exclusion database tests were used to simulate diverse species compositions, including three positive control and two negative control datasets. Using these simulated datasets ranging from 36 to 302 marker genes, we were able to identify between 19% and 89% of marine vertebrate species using mitochondrial markers. We show that MMSeqs2 and Metabuli generally outperform BLAST with 10% and 11% higher F1 scores for 12S and 16S rDNA markers, respectively, and that Naive Bayes Classifiers such as Mothur outperform sequence\u2010based classifiers except MMSeqs2 for COI markers by 11%. Database exclusion tests reveal that MMSeqs2 and BLAST are less susceptible to false positives compared to Kraken2 with default parameters. Based on these findings, we recommend that MMSeqs2 is used for taxonomic classification of marine vertebrates given its ability to improve species\u2010level assignments while reducing the number of false positives. Our work contributes to the establishment of best practices in eDNA\u2010based biodiversity analysis to ultimately increase the reliability of this monitoring tool in the context of marine vertebrate conservation.<\/jats:p>","DOI":"10.1111\/1755-0998.14107","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T08:35:27Z","timestamp":1744878927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Comprehensive Evaluation of Taxonomic Classifiers in Marine Vertebrate\n eDNA<\/scp>\n Studies"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8530-3067","authenticated-orcid":false,"given":"Philipp E.","family":"Bayer","sequence":"first","affiliation":[{"name":"Minderoo Foundation Perth Western Australia Australia"},{"name":"Minderoo OceanOmics Centre at UWA, Oceans Institute The University of Western Australia Crawley Western Australia 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3078-5534","authenticated-orcid":false,"given":"Madalyn","family":"Cooper","sequence":"additional","affiliation":[{"name":"Minderoo Foundation Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9314-5844","authenticated-orcid":false,"given":"Marcelle E.","family":"Ayad","sequence":"additional","affiliation":[{"name":"Minderoo Foundation Perth Western Australia Australia"},{"name":"Minderoo OceanOmics Centre at UWA, Oceans Institute The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"McVey","sequence":"additional","affiliation":[{"name":"Minderoo Foundation Perth Western Australia 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The IUCN Red List of Threatened Species 2019 e. 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Highly viewed videos related to neurodiversity on TikTok have an increasing role in understanding and acceptance of neurodivergent individuals. However, little is known about the type of such highly viewed TikTok content, including how neurodivergent individuals depict themselves or are depicted by others. This study aimed to explore neurodivergent content within highly viewed TikTok videos using autism and attention-deficit\/hyperactivity disorder (ADHD)-related hashtags.\n <\/jats:p>\n \n \n Methods:<\/jats:italic>\n <\/jats:bold>\n We identified publicly available videos (\n n<\/jats:italic>\n = 500) using hashtags with high view counts (#autism, #actuallyautistic, #autismawareness, #autismacceptance, #audhd, #adhd, #adhdtiktok, #adhdcheck, #adhdawareness, #neurospicy; 50 selected per hashtag). We coded videos identified for feature extraction for engagement metrics, demographics, and type of included content, with 20% randomly selected for qualitative reflexive thematic analysis.\n <\/jats:p>\n \n \n Results:<\/jats:italic>\n <\/jats:bold>\n Most videos depicted creators with lived experience of ADHD and\/or autism, with videos using ADHD hashtags most often from the perspective of individuals with ADHD and autism videos including a broader range of perspectives from autistic creators and loved ones (parents, siblings, partners). Most content shared personal experiences, often with humorous or self-deprecating overtures. We developed several themes: (1) lived neurodivergent experiences, (2) sensory differences and experiences, (3) family and relationships, and (4) portrayals of neurodivergence. Subthemes included invisible presentations of autism and ADHD, appreciation for community support and accommodations, sharing of strengths and challenges, and the impact of co-occurring conditions.\n <\/jats:p>\n \n \n Discussion:<\/jats:italic>\n <\/jats:bold>\n Engaging on social media can be a powerful medium to find and enhance feelings of connection with the autistic and ADHD communities, with various perspectives and experiences portrayed by creators using neurodiversity-related\u00a0hashtags. Further research is needed to understand how users perceive or interpret such content, both within and outside the neurodivergent community.\n <\/jats:p>","DOI":"10.1089\/aut.2025.0006","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T10:01:07Z","timestamp":1750672867000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Autism and Attention-Deficit\/Hyperactivity Disorder Content in Highly Viewed TikTok Videos"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-5919","authenticated-orcid":false,"given":"Gail A.","family":"Alvares","sequence":"first","affiliation":[{"name":"The Kids Research Institute Australia, The University of Western Australia, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-674X","authenticated-orcid":false,"given":"Chris","family":"Edwards","sequence":"additional","affiliation":[{"name":"Aspect Research Centre for Autism Practice, Autism Spectrum Australia, New South Wales, Australia."},{"name":"Inclusive Futures, Griffith University, Queensland, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3705-5323","authenticated-orcid":false,"given":"Melissa","family":"Licari","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, The University of Western Australia, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8244-6588","authenticated-orcid":false,"given":"Larissa","family":"Marion","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, The University of Western Australia, Western Australia, Australia."},{"name":"School of Psychological Science, The University of Western Australia, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0355-3850","authenticated-orcid":false,"given":"Caitlin","family":"Munro","sequence":"additional","affiliation":[{"name":"Curtin enAble Institute, Curtin University, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7677-0878","authenticated-orcid":false,"given":"Emily","family":"Munro","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, The University of Western Australia, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2947-988X","authenticated-orcid":false,"given":"Rigel","family":"Paciente","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, The University of Western Australia, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0161-144X","authenticated-orcid":false,"given":"Lexy","family":"Staniland","sequence":"additional","affiliation":[{"name":"Curtin enAble Institute, Curtin University, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9875-0704","authenticated-orcid":false,"given":"Daniel","family":"Ta","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, The University of Western Australia, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3427-351X","authenticated-orcid":false,"given":"Alix","family":"Woolard","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, The University of Western Australia, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/13591045221106573"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.2196\/28152"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copsyc.2021.08.017"},{"key":"e_1_3_6_5_1","unstructured":"4. 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We have previously shown that mesenchymal stromal cell (MSC) infusions are well tolerated in patients with COPD and reduce circulatory biomarkers associated with systemic inflammation and oxidative stress. This study aimed to delineate the underlying mechanisms further by characterizing the transcriptional networks in these patients and to explore the role of MSC-derived paracrine factors in regulating these pathways. Allogeneic, bone marrow-derived MSCs were systemically administered into patients with stable COPD (n\u00a0=\u00a09). Gene expression profiles from peripheral blood mononuclear cells (PBMCs) were analyzed across the first week after infusion. Paracrine mechanisms associated with these transcriptional changes were explored further by culturing patient PBMCs with MSC-conditioned medium (MSC-CM) or post-MSC infusion (PI) plasma to measure the regulatory effects of soluble factors that may be derived from MSCs. MSC-CM and PI-plasma were characterized further to identify potential immunoregulatory candidates. MSC infusion elicited a strong but transient transcriptional response in patient PBMCs that was sustained up to 7\u2009days. MSC infusion strongly downregulated transcriptional pathways related to interleukin (IL)-8 and IL-1\u03b2, which were also significantly inhibited in vitro following co-culture of PBMCs with MSC-CM and PI-plasma. MSC-derived soluble tumor necrosis factor receptor-1, transforming growth factor-\u03b21, and extracellular vesicle-associated microRNAs were identified as potential mechanisms promoting these changes, but depletion of these individual candidates revealed inconsistent results. MSC-derived paracrine factors modulate important inflammatory pathways that are relevant to COPD pathogenesis. These data strengthen the hypothesis that therapies using MSCs and their secreted products may be beneficial to patients with COPD.<\/jats:p>","DOI":"10.1002\/sctm.21-0024","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T11:45:21Z","timestamp":1629287121000},"page":"1470-1481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Transcriptional Profiling of Circulating Mononuclear Cells from Patients with Chronic Obstructive Pulmonary Disease receiving Mesenchymal Stromal Cell Infusions"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6558-5914","authenticated-orcid":false,"given":"Jesse D.","family":"Armitage","sequence":"first","affiliation":[{"name":"Centre for Respiratory Health, School of Biomedical Sciences \u00a0 , Nedlands, Western Australia, Australia"},{"name":"University of Western Australia \u00a0 , Nedlands, Western Australia, Australia"},{"name":"Stem Cell Unit \u00a0 , Nedlands, Western Australia, Australia"},{"name":"Institute for Respiratory Health \u00a0 , Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dino B.A.","family":"Tan","sequence":"additional","affiliation":[{"name":"Centre for Respiratory Health, School of Biomedical Sciences \u00a0 , Nedlands, Western Australia, Australia"},{"name":"University of Western Australia \u00a0 , Nedlands, Western Australia, Australia"},{"name":"Stem Cell Unit \u00a0 , Nedlands, Western Australia, Australia"},{"name":"Institute for Respiratory Health \u00a0 , Nedlands, Western Australia, Australia"},{"name":"Cell and Tissue Therapies WA \u00a0 , Perth, Western Australia, Australia"},{"name":"Royal Perth Hospital \u00a0 , Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Sturm","sequence":"additional","affiliation":[{"name":"Cell and Tissue 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of oral glucose tolerance test in rural and remote Western Australia.<\/jats:p><\/jats:sec>Design and participants<\/jats:title>Retrospective audit of 551 antenatal records from women of 16 years and older without pre\u2010existing diabetes and with singleton pregnancies delivered in 2013.<\/jats:p><\/jats:sec>Main outcome measures<\/jats:title>Number of women recorded screened for gestational diabetes mellitus in second or third trimester using oral glucose tolerance test or other tests; gestational diabetes mellitus rate.<\/jats:p><\/jats:sec>Results<\/jats:title>Only 278 (50.5%) women were screened with oral glucose tolerance test; 113 (20.5%) had no record of any screening related to gestational diabetes mellitus. In a nested mixed\u2010effects logistic regression model, women with a previous gestational diabetes mellitus diagnosis, two or more risk factors (excluding ethnicity) or high\u2010risk gestational diabetes mellitus ethnicity other than Australian Aboriginal were more likely to be screened, while Australian Aboriginal women were less likely to be screened with oral glucose tolerance test. Clinicians reported patient and clinician factors and logistical difficulties as reasons for the oral glucose tolerance test not being completed at their site. Of those screened with oral glucose tolerance test, a high rate of gestational diabetes mellitus was diagnosed (14.7% versus Western Australia state\u2010wide average of 7.4%).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Adherence to oral glucose tolerance test screening in rural Western Australia is inadequate for effective screening for gestational diabetes mellitus. Screening was not acceptable or available for a significant proportion of women at risk. Efforts to improve oral glucose tolerance test adherence and exploration of alternative gestational diabetes mellitus screening strategies are required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajr.12465","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T20:45:58Z","timestamp":1548794758000},"page":"64-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Diabetes screening in pregnancy failing women in rural Western Australia: An audit of oral glucose tolerance test completion rates"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-5333","authenticated-orcid":false,"given":"Andrew B.","family":"Kirke","sequence":"first","affiliation":[{"name":"Rural Clinical School of Western Australia University of Western Australia Bunbury Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Rural Clinical School of Western Australia University of Western Australia Bunbury Western Australia Australia"},{"name":"Kimberley Aboriginal Medical Services Council Broome Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Moore","sequence":"additional","affiliation":[{"name":"Rural Clinical School of Western Australia University of Western Australia Bunbury Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kylie","family":"Sterry","sequence":"additional","affiliation":[{"name":"Rural Clinical School of Western Australia University of Western Australia Bunbury Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Singleton","sequence":"additional","affiliation":[{"name":"Rural Clinical School of Western Australia University of Western Australia Bunbury Western Australia Australia"},{"name":"Kimberley Aboriginal Medical Services Council Broome Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9536-483X","authenticated-orcid":false,"given":"Carly","family":"Roxburgh","sequence":"additional","affiliation":[{"name":"Rural Clinical School of Western Australia University of Western Australia Bunbury Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Parrish","sequence":"additional","affiliation":[{"name":"Veterinary Virology Elizabeth Macarthur Agricultural Institute Menangle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Porter","sequence":"additional","affiliation":[{"name":"Combined Universities Centre for Rural Health Geraldton Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1014-4860","authenticated-orcid":false,"given":"Julia V.","family":"Marley","sequence":"additional","affiliation":[{"name":"Rural Clinical School of Western Australia University of Western Australia Bunbury Western Australia Australia"},{"name":"Kimberley Aboriginal Medical Services Council Broome Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60679-X"},{"key":"e_1_2_7_3_1","unstructured":"GeeV.Perinatal Statistics in Western Australia: Eleventh Annual Report of the Western Australian Midwives\u2019 Notification System 1993. 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Risks to health are compounded by poor health literacy, that is, reduced capacity to access health services, respond quickly to changes in health status and navigate care pathways. Building health literacy skills is a strength-based way to increase health and optimise the use of healthcare services. The internet is a primary source of health information for many people, including people with intellectual disability and their families. This scoping review will aim to identify and collate online lay healthcare resources available to and developed for people with intellectual disability and their families and evaluate whether domains of health literacy are addressed.<\/jats:p>\n <\/jats:sec>\n \n Methods and analysis<\/jats:title>\n This review will be reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews guidelines. The proposed search strategy has three components. Resources will be identified by (1) reviewing disability organisation websites, (2) searching key disability and health terms in the Google search engine and (3) snowball sampling to identify additional resources through links in identified websites and resources. Resources will be selected if they are freely available, presented in or translatable into English, provide health information and are directed to people with intellectual disability or their family members. Extracted data will include descriptors of the source, format, area of health and targeted age range. Content relevant to domains of health literacy will be documented and gaps in available health information will be identified. Study findings will be presented in narrative, tabular and visual forms.<\/jats:p>\n <\/jats:sec>\n \n Ethics and dissemination<\/jats:title>\n Ethical approval will not be sought because primary data will not be collected. The results will be disseminated in peer-reviewed literature, as conference presentations, as a synthesised resource for people with intellectual disability and their families and in summary documents for health service managers and policymakers.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2024-088509","type":"journal-article","created":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T14:35:52Z","timestamp":1732458952000},"page":"e088509","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Online health literacy resources for people with intellectual disability: protocol for a grey literature scoping review"],"prefix":"10.1136","volume":"14","author":[{"given":"Zhenmei","family":"Yeap","sequence":"first","affiliation":[{"name":"School of Psychological Science, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"The Kids Research Institute Australia, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Keeley","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7033-5063","authenticated-orcid":false,"given":"Rachel","family":"Skoss","sequence":"additional","affiliation":[{"name":"Institute for Health Research, The University of Notre Dame Australia, Fremantle, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Hunt","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Kickett","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacinta","family":"Saldaris","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Nevill","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7358-9037","authenticated-orcid":false,"given":"Jenny","family":"Downs","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,11,24]]},"reference":[{"key":"2025101814455149000_14.11.e088509.1","doi-asserted-by":"crossref","unstructured":"Schalock RL , Luckasson R , Tass\u00e9 MJ . Intellectual Disability: Definition, Diagnosis, Classification, and Systems of Supports. 12th edn. 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Inequalities and inequities in the health of people with intellectual disabilities. Oxford Res Encycl Glob Public Health 2021. doi:10.1093\/acrefore\/9780190632366.013.326","DOI":"10.1093\/acrefore\/9780190632366.013.326"},{"key":"2025101814455149000_14.11.e088509.11","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-009-0050-x"},{"key":"2025101814455149000_14.11.e088509.12","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2458-12-80","article-title":"Health literacy and public health: a systematic review and integration of definitions and models","volume":"12","author":"S\u00f8rensen","year":"2012","journal-title":"BMC Public Health"},{"key":"2025101814455149000_14.11.e088509.13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.puhe.2016.01.001","article-title":"Health literacy: applying current concepts to improve health services and reduce health inequalities","volume":"132","author":"Batterham","year":"2016","journal-title":"Public Health (Fairfax)"},{"key":"2025101814455149000_14.11.e088509.14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.adolescence.2017.11.010","article-title":"Adolescent health literacy and health behaviors: A systematic review","volume":"62","author":"Fleary","year":"2018","journal-title":"J Adolesc"},{"key":"2025101814455149000_14.11.e088509.15","doi-asserted-by":"publisher","DOI":"10.1017\/cem.2017.15"},{"key":"2025101814455149000_14.11.e088509.16","doi-asserted-by":"crossref","DOI":"10.3399\/bjgpopen20X101030","article-title":"Barriers and facilitators to primary health care for people with intellectual disabilities and\/or autism: an integrative review","volume":"4","author":"Doherty","year":"2020","journal-title":"BJGP Open"},{"key":"2025101814455149000_14.11.e088509.17","unstructured":"Centers for Disease Control and Prevention (U.S.) . How to develop products for adults with intellectual developmental disabilities and extreme low literacy: a product development tool. 2023."},{"key":"2025101814455149000_14.11.e088509.18","doi-asserted-by":"crossref","DOI":"10.1186\/s12889-021-12027-6","article-title":"Sexual health concerns in women with intellectual disabilities: a systematic review in qualitative studies","volume":"21","author":"Matin","year":"2021","journal-title":"BMC Public Health"},{"key":"2025101814455149000_14.11.e088509.19","doi-asserted-by":"crossref","DOI":"10.3390\/healthcare11121742","article-title":"Building Evidence for Principles to Guide the Development of Products for Adults with Intellectual and Developmental Disabilities and Extreme Low Literacy-A Product Development Tool","volume":"11","author":"Squiers","year":"2023","journal-title":"Healthcare (Basel)"},{"key":"2025101814455149000_14.11.e088509.20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/0951484817733366","article-title":"Examining the impacts of health literacy on healthcare costs. An evidence synthesis","volume":"30","author":"Palumbo","year":"2017","journal-title":"Health Serv Manage Res"},{"key":"2025101814455149000_14.11.e088509.21","doi-asserted-by":"crossref","first-page":"525","DOI":"10.5694\/j.1326-5377.2009.tb03301.x","article-title":"Building health literacy in Australia","volume":"191","author":"Nutbeam","year":"2009","journal-title":"Med J Aust"},{"key":"2025101814455149000_14.11.e088509.22","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1002\/cncr.31733","article-title":"Health literacy and cancer self-management behaviors: A scoping review","volume":"124","author":"Papadakos","year":"2018","journal-title":"Cancer"},{"key":"2025101814455149000_14.11.e088509.23","doi-asserted-by":"crossref","DOI":"10.2196\/18476","article-title":"Applying the Electronic Health Literacy Lens: Systematic Review of Electronic Health Interventions Targeted at Socially Disadvantaged Groups","volume":"22","author":"Cheng","year":"2020","journal-title":"J Med Internet Res"},{"key":"2025101814455149000_14.11.e088509.24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1352\/1944-7558-125.5.389","article-title":"Health Literacy and Health Outcomes Among Children With Developmental Disabilities: A Systematic Review","volume":"125","author":"Lindly","year":"2020","journal-title":"Am J Intellect Dev Disabil"},{"key":"2025101814455149000_14.11.e088509.25","doi-asserted-by":"publisher","DOI":"10.1080\/1364557032000119616"},{"key":"2025101814455149000_14.11.e088509.26","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-025892","article-title":"Towards sustainable healthcare system performance in the 21st century in high-income countries: a protocol for a systematic review of the grey literature","volume":"9","author":"Braithwaite","year":"2019","journal-title":"BMJ Open"},{"key":"2025101814455149000_14.11.e088509.27","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-071682","article-title":"How do hospitals address health inequalities experienced by children and young people: a grey literature scoping review protocol","volume":"13","author":"Brennan","year":"2023","journal-title":"BMJ Open"},{"key":"2025101814455149000_14.11.e088509.28","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"2025101814455149000_14.11.e088509.29","unstructured":"Centre for Inclusive Design . A guide to creating accessible content. 2020. Available: https:\/\/centreforinclusivedesign.org.au\/wp-content\/uploads\/2020\/04\/Easy-English-vs-Plain-English_accessible.pdf"}],"container-title":["BMJ Open"],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2024-088509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T21:46:00Z","timestamp":1760823960000},"score":7.6384144,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2024-088509"}},"issued":{"date-parts":[[2024,11]]},"references-count":29,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11,24]]},"published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1136\/bmjopen-2024-088509"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2024-088509","ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"published":{"date-parts":[[2024,11]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:35:21Z","timestamp":1753889721607,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Background: An acute increase in serum creatinine (AICr) after starting ACE inhibitor is frequently observed, and consideration of discontinuation has been recommended if creatinine values increased 30% or more. However, the long term effect of continuation or discontinuation of that therapy is unclear.<\/jats:p>\n Objective: To examine the association of AICr after starting a fixed combination of perindopril-indapamide and its continuation or discontinuation, with clinical outcomes using data from the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial.<\/jats:p>\n Research Design and Methods: A total of 11,140 diabetes patients were randomly assigned to a fixed combination of perindopril-indapamide or placebo after a 6-week active run-in period. These analyses included 11,066 patients with 2 measurements of serum creatinine, before and during the active run-in period (3 weeks apart). AICr was determined using these 2 measurements, classified into 4 groups: &lt;10%, 10-19%, 20-29%, and \u226530%.<\/jats:p>\n Results: AICr after starting perindopril-indapamide in the run-in period was subsequently associated with an increased risk of a composite of major macrovascular events, new or worsening nephropathy, all-cause mortality, in both randomized groups (P for trend &lt;0.for each). However, a consistent benefit of randomized treatment for the outcome was observed across subgroups defined by AICr, with no heterogeneity in the magnitude of the effects (P for heterogeneity = 0.94). Similar results were observed for major macrovascular events alone, new or worsening nephropathy alone, and all-cause mortality alone.<\/jats:p>\n Conclusions: AICr after starting ACE inhibitor was associated with an increased risk of clinical outcomes, irrespective of continuation or discontinuation of the therapy. However, randomized treatment effects are consistent and beneficial across subgroups defined by AICr.<\/jats:p>\n \n Disclosure<\/jats:title>\n T. Ohkuma: None. M. Jun: None. M. Woodward: None. J. Chalmers: Research Support; Self; Servier. Other Relationship; Self; Servier. V. Perkovic: Speaker's Bureau; Self; Mitsubishi Tanabe Pharma Corporation. Advisory Panel; Self; Merck Sharp & Dohme Corp.. Consultant; Self; AbbVie Inc.. Advisory Panel; Self; Janssen Global Services, LLC.. Speaker's Bureau; Self; Novo Nordisk Inc.. Advisory Panel; Self; Novartis Pharmaceuticals Corporation, AstraZeneca, Gilead Sciences, Inc.. Consultant; Self; Servier. Speaker's Bureau; Self; Boehringer Ingelheim GmbH. Advisory Panel; Self; Eli Lilly and Company. A. Rodgers: Other Relationship; Self; George Health Enterprises.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-1483-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:32Z","timestamp":1529693852000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Acute Increase in Creatinine after Starting ACE Inhibitor and Vascular Events and Premature Death in Patients with Type 2 Diabetes\u2014The ADVANCE Trial"],"prefix":"10.2337","volume":"67","author":[{"given":"TOSHIAKI","family":"OHKUMA","sequence":"first","affiliation":[{"name":"Camperdown, Australia, Newtown, Australia, Oxford, United Kingdom, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIN","family":"JUN","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Newtown, Australia, Oxford, United Kingdom, Sydney, 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As maternal factors, such as age, smoking, and body mass index have been associated with breast milk composition, we aimed to identify maternal characteristics associated with the concentration of food allergens in breast milk. A PROSPERO (CDR42024558231) registered systematic review search was conducted in MEDLINE, EMBASE, Cochrane Library, CINAHL and Scopus until March 10th, 2025. Article inclusion criteria were human studies, where participants consumed a standardized amount of a common food allergen prior to breast milk sampling, and the concentration of that food allergen was measured in their breast milk. Seventeen articles were included in the systematic review. Despite a standardized amount of food allergen consumption, large inter\u2010individual variations were reported in food allergen breast milk concentrations. Maternal allergic disease (four studies), amount of the food allergen typically eaten by the mother (two studies), stage of lactation (one study) and mammary epithelium permeability (one study) were the only maternal factors examined. No studies reported significant associations between these maternal characteristics and food allergen breast milk concentrations. No previous studies have been specifically designed to determine whether maternal characteristics are associated with food allergen breast milk concentrations. We therefore remain unable to explain large variations in inter\u2010individual food allergen breast milk concentrations. New adequately powered studies are needed to investigate associations with maternal factors previously found to influence breast milk composition, such as age, smoking, body mass index and stage of lactation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pai.70117","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:44:38Z","timestamp":1748825078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Concentration of food allergens in breastmilk and association with maternal factors\u2013 A systematic review"],"prefix":"10.1111","volume":"36","author":[{"given":"Sophie A.","family":"Hughes","sequence":"first","affiliation":[{"name":"School of Molecular Sciences The University of Western Australia Crawley Western Australia Australia"},{"name":"ABREAST Network Perth Western Australia Australia"},{"name":"Centre for Human Lactation Research and Translation The University of Western 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Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kurrle","sequence":"additional","affiliation":[{"name":"Sydney University, Sydney, New South Wales, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Kaambwa","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ratcliffe","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Chehade","sequence":"additional","affiliation":[{"name":"Adelaide University, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,6,30]]},"container-title":["Innovation in Aging"],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/innovateage\/article-pdf\/1\/suppl_1\/947\/26125397\/igx004.3404.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T18:23:07Z","timestamp":1540232587000},"score":7.637609,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/innovateage\/article\/1\/suppl_1\/947\/3900496"}},"issued":{"date-parts":[[2017,6,30]]},"references-count":0,"journal-issue":{"issue":"suppl_1","published-online":{"date-parts":[[2017,6,30]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/geroni\/igx004.3404","ISSN":["2399-5300"],"issn-type":[{"value":"2399-5300","type":"electronic"}],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2017,6,30]]}},{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:06:41Z","timestamp":1780704401685,"version":"3.54.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2026,6,5]]},"abstract":"Introduction and Objective: Adolescents with severe obesity are at high risk for insulin resistance and youth-onset type 2 diabetes (Y-T2D). Intensive weight-loss interventions are increasingly used to prevent progression to Y-T2D and enable remission in early disease; however, their impact on health-related quality of life (HRQoL) has not been characterised.<\/jats:p>\n Methods: Adolescents aged 15-17 years with severe obesity (BMI \u226535 kg\/m\u00b2) completed a 12-week very low-calorie diet (VLCD) using the Optifast\u00ae program. HRQoL was assessed using the Short Form-36 (SF-36) at baseline, post-VLCD, and follow-up (6-36 months). After VLCD completion, eligible participants were offered bariatric surgery. SF-36 domain and total scores (0-100) were analysed using linear mixed-effects models including time, surgery status, and interaction terms. Clinically meaningful change was defined as \u22653-5 points.<\/jats:p>\n Results: At baseline, participants (45% Y-T2D, 40% pre-diabetes) demonstrated HRQoL impairment (mean SF-36 total 50.0\u00b112.9), particularly in role physical, role emotional, and mental health domains. Following VLCD, SF-36 total score increased by ~9 points (p=0.005). Significant improvements were observed in physical functioning (+18.1), role physical (+29.8), role emotional (+32.1), and social functioning (+21.5) (all p&lt;0.05). Vitality (\u221213.8) and mental health (\u221211.7) declined during VLCD (both p&lt;0.05). During follow-up, surgery was associated with higher physical functioning and lower pain burden, while vitality and mental health improved over time in both groups. The proportion with Y-T2D dropped from 43% to 0% after surgery but was unchanged with VLCD alone (46% vs 46%).<\/jats:p>\n Conclusion: Among adolescents with severe obesity targeted for Y-T2D prevention and potential remission, VLCD produced rapid, clinically meaningful improvements in physical and role-based HRQoL despite transient reductions in vitality and mental well-being. Bariatric surgery conferred sustained functional advantages during longer-term follow-up.<\/jats:p>\n \n Disclosure<\/jats:title>\n K. Perera: None. J. Baker: None. K. Smallman: None. K.A. Pickering: None. P.J. Harry: None. D.J. Anderson: None. B. Orr-Walker: None. R. Babor: None. D. Simmons: Speaker's Bureau; Ended; Novo Nordisk. Other - Educational grant; Ended; Abbott Diabetes. Research Support; Current; Novo Nordisk. Consultant; Ended; Dexcom, Inc.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db26-2084-p","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:55:44Z","timestamp":1780703744000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["2084-P: Health-Related Quality of Life following Diabetes Prevention\u2013Focused Weight-Loss Interventions in Adolescents with Severe Obesity"],"prefix":"10.2337","volume":"75","author":[{"given":"KANCHANA","family":"PERERA","sequence":"first","affiliation":[{"name":"Sydney, Australia, Auckland, New Zealand, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOHN","family":"BAKER","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Auckland, New Zealand, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KATE","family":"SMALLMAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Auckland, New Zealand, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAREN A.","family":"PICKERING","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Auckland, New Zealand, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PATRICIA J.","family":"HARRY","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Auckland, New Zealand, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIANA J.","family":"ANDERSON","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Auckland, New Zealand, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BRANDON","family":"ORR-WALKER","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Auckland, New Zealand, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RICHARD","family":"BABOR","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Auckland, New Zealand, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVID","family":"SIMMONS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Auckland, New Zealand, Penrith, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/2084-P\/168116\/2084-P-Health-Related-Quality-of-Life-following","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/2084-P\/168116\/2084-P-Health-Related-Quality-of-Life-following","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:55:44Z","timestamp":1780703744000},"score":7.637508,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/2084-P\/168116\/2084-P-Health-Related-Quality-of-Life-following"}},"issued":{"date-parts":[[2026,6,5]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2026,6,5]]}},"URL":"https:\/\/doi.org\/10.2337\/db26-2084-p","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2026,6,5]]},"article-number":"2084-P"},{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:44:04Z","timestamp":1787600644407,"version":"build-2736575974"},"reference-count":76,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015742","name":"Forrest Research Foundation","doi-asserted-by":"publisher","award":["Forrest Research Foundation Scholarship"],"award-info":[{"award-number":["Forrest Research Foundation Scholarship"]}],"id":[{"id":"10.13039\/100015742","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["conbio.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Conservation Biology"],"abstract":"Abstract<\/jats:title>\n The sustainability of area\u2010based conservation initiatives depends on their value to society. Conservation often focuses inside protected areas, but the impacts of protected areas beyond their boundaries (spillovers) are critical for their social license. Despite their importance, spillovers remain poorly documented and difficult to characterize. To understand the current state of the field and identify avenues for improved generalization, we reviewed 51 spillover analyses of terrestrial protected areas published between 2000 and 2024. We identified several pervasive problems, including widespread use of unvalidated or proportionally scaled sampling zones, biased and incomplete coverage of different regions and ecosystem types, insufficient attention to spatial autocorrelation, statistical inadequacies, and a general failure to conceptualize spillover analysis as a hypothesis\u2010testing inquiry into scale and protected area effect size. We argue that the lack of standardized methodological and reporting frameworks for spillover analysis has led to inconsistent sampling designs and unmatched spatial and temporal scales of analysis. Few studies consider spatial patterns of nonecological spillovers and their interactions with ecosystems, and limited integration of legal and management frameworks further constrains the capacity of spillover analysis to inform and be integrated with global conservation efforts and targets (e.g., the 30\u00d730 goal of the Global Biodiversity Framework). We propose a set of methodological recommendations and best practices for reporting, sampling design, and analytical decisions. Improved rigor and comparability between studies are needed so that meta\u2010analyses can be conducted to support global conservation policy for spillover governance. We suggest that future research and conservation practice focus on improving sampling designs and guiding analytical decisions for spillover analyses that explicitly define appropriate sampling distances and spatial granularity, incorporate spatial autocorrelation, and more deliberately consider ecosystem heterogeneity.<\/jats:p>","DOI":"10.1111\/cobi.70361","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:19:43Z","timestamp":1784603983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Review and Critique of Methods and Knowledge Gaps in Quantifying Spillover Effects from Protected Areas"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6892-6609","authenticated-orcid":false,"given":"Ilaria","family":"Gliottone","sequence":"first","affiliation":[{"name":"Oceans Institute University of Western Australia Crawley Western Australia Australia"},{"name":"School of Earth and Oceans University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0106-849X","authenticated-orcid":false,"given":"Teigan G.","family":"Collins","sequence":"additional","affiliation":[{"name":"Oceans Institute University of Western Australia Crawley Western Australia Australia"},{"name":"School of Earth and Oceans University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6039-7395","authenticated-orcid":false,"given":"Ennis","family":"de Vos","sequence":"additional","affiliation":[{"name":"Oceans Institute University of Western Australia Crawley Western Australia Australia"},{"name":"School of Earth and Oceans University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria Y.","family":"Mendez Angarita","sequence":"additional","affiliation":[{"name":"Oceans Institute University of Western Australia Crawley Western Australia Australia"},{"name":"School of Earth and Oceans University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwat","family":"Kongwarakom","sequence":"additional","affiliation":[{"name":"Oceans Institute University of Western Australia Crawley Western Australia Australia"},{"name":"School of Earth and Oceans University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme S.","family":"Cumming","sequence":"additional","affiliation":[{"name":"Oceans Institute University of Western Australia Crawley Western Australia Australia"},{"name":"School of Earth and Oceans University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1468-0262.2006.00655.x","article-title":"Large sample properties of matching estimators for average treatment effects","volume":"74","author":"Abadie A.","year":"2006","journal-title":"Econometrica"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pecon.2021.01.004","article-title":"Opportunities and challenges of other effective area\u2010based conservation measures (OECMs) for biodiversity conservation","volume":"19","author":"Alves\u2010Pinto H.","year":"2021","journal-title":"Perspectives in Ecology and Conservation"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"16089","DOI":"10.1073\/pnas.0800437105","article-title":"Measuring the effectiveness of protected area networks in reducing deforestation","volume":"105","author":"Andam K. S.","year":"2008","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1111\/ele.13106","article-title":"Biodiversity monitoring, earth observations and the ecology of scale","volume":"21","author":"Anderson C. B.","year":"2018","journal-title":"Ecology Letters"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocon.2022.109695","article-title":"No evidence of local deforestation leakage from protected areas establishment in Brazil's Amazon and Atlantic Forest","volume":"273","author":"Barros L. D.","year":"2022","journal-title":"Biological Conservation"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/conl.12180","article-title":"Mainstreaming impact evaluation in nature conservation","volume":"9","author":"Baylis K.","year":"2016","journal-title":"Conservation Letters"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5751\/ES-11713-250310","article-title":"Deforestation and economic growth trends on oceanic islands highlight the need for meso\u2010scale analysis and improved mid\u2010range theory in conservation","volume":"25","author":"Bhatia N.","year":"2020","journal-title":"Ecology and Society"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.agee.2011.09.005","article-title":"Spillover of functionally important organisms between managed and natural habitats","volume":"146","author":"Blitzer E. J.","year":"2012","journal-title":"Agriculture, Ecosystems & Environment"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/jpe\/rtr038","article-title":"Little left to lose: Deforestation and forest degradation in Australia since European colonization","volume":"5","author":"Bradshaw C. J. A.","year":"2012","journal-title":"Journal of Plant Ecology"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.scitotenv.2016.06.223","article-title":"The park\u2010view effect: Residential development is higher at the boundaries of protected areas","volume":"569","author":"Brambilla M.","year":"2016","journal-title":"Science of the Total Environment"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"E42","DOI":"10.1038\/s41586-024-08513-7","article-title":"Reply to: Causal claims, causal assumptions and protected area impact","volume":"638","author":"Brodie J. 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The aim of the present study was to describe the CS rates and the clinical indications for pre\u2010labor CS in the ORIGINS birth cohort.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This study analyzed data from the ORIGINS birth cohort, a large birth cohort in Western Australia, including 9473 births occurring at Joondalup Health Campus between 2016 and 2024. Rates of CS and pre\u2010labor CS were compared across study periods (2016\u20132020 and 2021\u20132024) and by facility type (public vs. private). Indications for pre\u2010labor CS were described and compared across study periods and facility type. Poisson regression was used to assess the change in CS rates across study periods, adjusted for maternal demographic and pregnancy characteristics.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Overall CS rates were 50.4% for the study cohort. They increased from 48.2% in 2016\u20132020 to 52.3% in 2021\u20132024 (adjusted risk ratio [aRR] 1.10, 95% confidence interval [CI] 1.06\u20131.14) and were 46.2% in public facilities and 62.0% in private facilities. Pre\u2010labor CS rates increased from 31.4% to 36.2% (aRR 1.15, 95% CI 1.10\u20131.23) and were 28.5% in public facilities and 49.1% in private facilities. Previous cesarean section was the most common indication for pre\u2010labor CS and increased in prevalence across study periods (from 50% to 53.2%). Pre\u2010labor CS performed at maternal request also increased (from 10.8% to 15.3%) and was more common in private hospital facilities (public, 10.8%; private, 17.7%).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n CS rates in the ORIGINS birth cohort appeared to be higher than in the broader Western Australian birthing population. Pre\u2010labor CS contributed substantially to rising CS rates in this cohort and was particularly common in private settings. Similarly, pre\u2010labor CS performed at maternal request increased over time and was more common in private settings. 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This study describes and documents the effectiveness of the culturally sensitive model within YouthLink, a state\u2010wide mental health service program in Western Australia for young people aged 13 to 24 years of age.<\/jats:p><\/jats:sec>Methods<\/jats:title>A mixed\u2010method design including a descriptive approach reporting on the YouthLink framework and an empirical research design where 40 Aboriginal clients completed client feedback monitoring measures between 2014 and 2016.<\/jats:p><\/jats:sec>Results<\/jats:title>The YouthLink culturally informed conceptual framework adheres to best practice principles relevant to work with Indigenous people, family and communities. Aboriginal young people indicated improvement across the treatment period as shown by within\u2010group differences between the first and last session scores on feedback measures. Therapeutic alliance (together with lower baseline acuity and female gender) also contributed significantly to positive treatment outcomes.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Through a strong role of Aboriginal practitioners, relationships with Aboriginal communities, and greater service flexibility that embraces cultural meaning and knowledge, YouthLink has sought to enhance its response to the needs of Aboriginal youth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12563","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:03:27Z","timestamp":1521936207000},"page":"987-994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Providing culturally informed mental health services to Aboriginal youth: The YouthLink model in Western Australia"],"prefix":"10.1111","volume":"12","author":[{"given":"Daniela","family":"Sabbioni","sequence":"first","affiliation":[{"name":"North Metro Health Service Mental Health Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Feehan","sequence":"additional","affiliation":[{"name":"North Metro Health Service Mental Health Perth Western Australia Australia"},{"name":"YouthLink Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Nicholls","sequence":"additional","affiliation":[{"name":"North Metro Health Service Mental Health Perth Western Australia Australia"},{"name":"YouthLink Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Soong","sequence":"additional","affiliation":[{"name":"North Metro Health Service Mental Health Perth Western Australia Australia"},{"name":"Youth Mental Health Program Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Rigoli","sequence":"additional","affiliation":[{"name":"North Metro Health Service Mental Health Perth Western Australia Australia"},{"name":"YouthLink Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Follett","sequence":"additional","affiliation":[{"name":"North Metro Health Service Mental Health Perth Western Australia Australia"},{"name":"YouthLink Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoff","family":"Carastathis","sequence":"additional","affiliation":[{"name":"North Metro Health Service Mental Health Perth Western Australia Australia"},{"name":"YouthLink Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Gomes","sequence":"additional","affiliation":[{"name":"North Metro Health Service Mental Health Perth Western Australia Australia"},{"name":"YouthLink Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Griffiths","sequence":"additional","affiliation":[{"name":"North Metro Health Service Mental Health Perth Western Australia Australia"},{"name":"YouthLink Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Curtis","sequence":"additional","affiliation":[{"name":"North Metro Health Service Mental Health Perth Western Australia Australia"},{"name":"YouthLink Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warwick","family":"Smith","sequence":"additional","affiliation":[{"name":"North Metro Health Service Mental Health Perth Western Australia Australia"},{"name":"Youth Mental Health Program Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavie","family":"Waters","sequence":"additional","affiliation":[{"name":"North Metro Health Service Mental Health Perth Western Australia Australia"},{"name":"Youth Mental Health Program Perth Western Australia Australia"},{"name":"School of Psychological Science University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,24]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Australian Institute of Health and Welfare. (2009a).Measuring the social and emotional wellbeing of Aboriginal and Torres Strait Islander peoples(ed. cat no. I. 24). Retrieved fromwww.aihw.gov.au\/WorkArea\/DownloadAsset.aspx?id=6442458717"},{"key":"e_1_2_7_3_1","unstructured":"Australian Institute of Health and Welfare. (2009b).Mental health Services in Australia 2006\u20132007. Mental health series no 11. (cat no. HSE 74). Retrieved fromwww.aihw.gov.au\/publication-detail\/?id=6442468277"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2007.01855.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.002052011"},{"key":"e_1_2_7_6_1","first-page":"31","article-title":"Towards a culturally appropriate mental health research process for Indigenous Australians","volume":"18","author":"Bishop B.","year":"2006","journal-title":"The Australian Community Psychologist"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-4458-8-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1584.2008.01003.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2012.07.002"},{"key":"e_1_2_7_10_1","first-page":"419","article-title":"Community life and development programs\u2013pathways to healing","author":"Dudgeon P.","year":"2014","journal-title":"Working together: Aboriginal and Torres Strait Islander mental health and wellbeing principles and practice"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/11436-017"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-12-96"},{"key":"e_1_2_7_13_1","unstructured":"Framework N.(2014).National Strategic Framework for Aboriginal and Torres Strait Islander peoples' mental health and social and emotional well being (2004\u20132009). Retrieved fromwww.ahmrc.org.au\/media\/resources\/social\u2010emotional\u2010wellbeing\/mental\u2010health\/328\u2010national\u2010strategic\u2010framework\u2010for\u2010aboriginal\u2010and\u2010torres\u2010strait\u2010islander\u2010peoples\u2010mental\u2010health\u2010and\u2010social\u2010and\u2010emotional\u2010well\u2010being\u20102004\u20102009\/"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-13-270"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.05.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.51.10.1059"},{"key":"e_1_2_7_17_1","first-page":"26","article-title":"Mental health in indigenous settings: Challenges for clinicians","volume":"43","author":"Hunter E.","year":"2014","journal-title":"Australian Family Physician"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0349.2009.00647.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60827-8"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-015-0664-x"},{"key":"e_1_2_7_21_1","volume-title":"Psychometrics of the ORS and SRS. Results from RCT's and Meta\u2010Analyses of Routine Outcome Monitoring and Feedback: The Available Evidence","author":"Miller S. D.","year":"2014"},{"key":"e_1_2_7_22_1","first-page":"91","article-title":"The outcome rating scale: A preliminary study of the reliability, validity, and feasibility of a brief visual analogue measure","volume":"2","author":"Miller S. D.","year":"2003","journal-title":"Journal of Brief Therapy"},{"key":"e_1_2_7_23_1","first-page":"5","article-title":"Using formal client feedback to improve retention and outcome: Making ongoing, real\u2010time assessment feasible","volume":"5","author":"Miller S. D.","year":"2006","journal-title":"Journal of Brief Therapy"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.20111"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00048670701449211"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ap.12125"},{"key":"e_1_2_7_27_1","first-page":"25","volume-title":"Working Together: Aboriginal and Torres Strait Islander mental health and wellbeing principles and practice","author":"Parker R.","year":"2014"},{"key":"e_1_2_7_28_1","volume-title":"National Aboriginal Health Strategy","author":"Party N. W.","year":"1989"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13033-015-0019-5"},{"key":"e_1_2_7_30_1","volume-title":"Psychology and Indigenous Australians: Foundations of cultural competence","author":"Ranzijn R.","year":"2009"},{"key":"e_1_2_7_31_1","unstructured":"Reibel T. &Walker R.(2010).Antenatal services for Aboriginal women: the relevance of cultural competence. Quality in Primary Care. Retrieved fromwww.primarycare.imedpub.com\/antenatal\u2010services\u2010for\u2010aboriginal\u2010women\u2010the\u2010relevance\u2010of\u2010cultural\u2010competence.php?aid=920"},{"issue":"3","key":"e_1_2_7_32_1","first-page":"298","article-title":"Enhancing treatment outcome of patients at risk of treatment failure: Meta\u2010analytic and mega\u2010analytic review of a psychotherapy quality assurance system","volume":"78","author":"Shimokawa K.","year":"2010","journal-title":"American Psychological Association"},{"key":"e_1_2_7_33_1","unstructured":"Sundet R.(2009).Client directed outcome informed therapy in an intensive family therapy unit: A study of the use of research generated knowledge in clinical practice. Dissertation (Faculty of Social Sciences University of Oslo No. 198). Retrieved fromwww.duo.uio.no\/bitstream\/handle\/10852\/18579\/Sundet-publ.pdf?sequence=3"},{"key":"e_1_2_7_34_1","volume-title":"Ways forward. National Consultancy Report on Aboriginal and Torres Strait Islander Mental Health","author":"Swan P.","year":"1995"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/00050060512331317210"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyn240"},{"key":"e_1_2_7_37_1","first-page":"157","volume-title":"Working Together: Aboriginal and Torres Strait Islander Mental Health and Wellbeing Principles and Practice","author":"Walker R.","year":"2010"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.5172\/jamh.3.3.88"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/00050060903451790"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.1999.tb01240.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.172.1.11"},{"key":"e_1_2_7_42_1","first-page":"75","volume-title":"Working together: Aboriginal and Torres Strait Islander Mental Health and Wellbeing Principles and Practice","author":"Zubrick S. R.","year":"2010"}],"container-title":["Early Intervention in Psychiatry"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feip.12563","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eip.12563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T09:46:42Z","timestamp":1695030402000},"score":7.6361275,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eip.12563"}},"issued":{"date-parts":[[2018,3,24]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/eip.12563"],"URL":"https:\/\/doi.org\/10.1111\/eip.12563","archive":["Portico"],"ISSN":["1751-7885","1751-7893"],"issn-type":[{"value":"1751-7885","type":"print"},{"value":"1751-7893","type":"electronic"}],"published":{"date-parts":[[2018,3,24]]},"assertion":[{"value":"2017-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:39:52Z","timestamp":1772159992368,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006065","name":"Department of Health, Government of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2022,3]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n The proportion of patients who recommence clozapine after cessation, the time taken to resume clozapine post\u2010cessation, and distinguishing demographic and clinical characteristics of this group have been poorly researched. We evaluated these in the current study.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n We retrospectively extracted selected demographic and clinical variables and clozapine treatment interruption and recommencement data up to December 2018 of a cohort of 458 patients who first commenced clozapine between 2006 and 2016. The study was conducted at three Australian health services.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 310 (69%) patients who had at least one interruption of clozapine treatment, 170 (54.8%) did not resume clozapine, and 140 (45.2%) recommenced it after the first interruption. More than half of those who recommenced did so within a month and 80% by 12\u00a0months. Cox regression analysis revealed that age was significantly associated with recommencement, with a 2% decrease in the likelihood of restarting after an interruption for each year later that clozapine was initially commenced (HR\u00a0=\u00a00.98 95%CI: 0.97, 0.997,\n p<\/jats:italic>\n \u00a0=\u00a00.02). Those who ceased clozapine due to adverse effects were less likely to restart than those who ceased due to noncompliance (HR\u00a0=\u00a00.63 95%CI: 0.41, 0.97,\n p<\/jats:italic>\n \u00a0=\u00a00.03). More time on clozapine prior to interruption increased the likelihood of restarting it, with each additional month on clozapine increasing this likelihood by 1% (HR\u00a0=\u00a01.01 95%CI: 1.01, 1.02,\n p<\/jats:italic>\n \u00a0<\u00a00.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n If the distinguishing demographic and clinical characteristics of the group identified in this study are corroborated through further research, this could further validate the need to identify treatment resistance and commence clozapine early in people with schizophrenia and provide appropriate interventions to those more at risk of permanent discontinuation of clozapine.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/acps.13394","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T12:48:19Z","timestamp":1640695699000},"page":"293-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Demographic and clinical characteristics of patients who recommence clozapine following therapy interruptions"],"prefix":"10.1111","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1989-6578","authenticated-orcid":false,"given":"Alexander Panickacheril","family":"John","sequence":"first","affiliation":[{"name":"Bentley Health Service Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Burrows","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"},{"name":"Royal Perth Hospital Research Foundation Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Stanley","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherry","family":"Acabo","sequence":"additional","affiliation":[{"name":"Bentley Health Service Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Shymko","sequence":"additional","affiliation":[{"name":"Peel and Rockingham Kwinana Health Service Cooloongup South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Jaworska","sequence":"additional","affiliation":[{"name":"Bentley Health Service Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Velayudhan","sequence":"additional","affiliation":[{"name":"Fremantle Hospital Health Service Palmyra DC Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.115.177261"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2016.01.006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60742-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.1322"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.16091097"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S146114571100201X"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-018-0565-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10401239509149622"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.175.6.576"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199803000-00003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0416"},{"key":"e_1_2_9_13_1","first-page":"211","article-title":"Continuation of clozapine treatment: practice makes perfect","volume":"27","author":"Whiskey E","year":"2003","journal-title":"Psychiatrist"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0911"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0708"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e32834ab34c"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12233"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.05.002"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881118760666"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.01.110"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200519120-00006"},{"key":"e_1_2_9_22_1","first-page":"253","article-title":"The risk of suicide after clozapine discontinuation: cause for concern","volume":"27","author":"Patchan 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There are conflicting reports about Aboriginal Australians and MSP<\/jats:styled-content>. We conducted a systematic review to describe the prevalence, associated factors, impacts, care access, health care experiences, and factors associated with MSP<\/jats:styled-content> among Aboriginal Australians.<\/jats:p><\/jats:sec>Methods<\/jats:title>We used a systematic search of quantitative and qualitative scientific and grey literature (PROSPERO<\/jats:styled-content># CRD<\/jats:styled-content>42016038342). Articles were appraised using the Mixed Methods Appraisal Tool. Due to study heterogeneity, a narrative synthesis was conducted.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 536 articles identified, 18 were included (14 quantitative, 4 qualitative), of high (n = 11), medium (n = 2), and low (n = 5) quality. Prevalence of MSP<\/jats:styled-content> in Aboriginal populations was similar to or slightly higher than the non\u2010Aboriginal population (prevalence rate ratio 1.1 for back pain, 1.2\u20131.5 for osteoarthritis [OA<\/jats:styled-content>], and 1.0\u20132.0 for rheumatoid arthritis). Aboriginal people accessed primary care for knee or hip OA<\/jats:styled-content> at approximately half the rate of non\u2010Aboriginal people, and were less than half as likely to have knee or hip replacement surgery. Communication difficulties with health practitioners were the main reason why Aboriginal people with MSP<\/jats:styled-content> choose not to access care. No articles reported interventions.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Findings provide preliminary evidence of an increased MSP<\/jats:styled-content> burden among Aboriginal Australians, and particularly for OA<\/jats:styled-content>, a mismatch between the disease burden and access to health care. To increase accessibility, health services should initially focus on improving Aboriginal patients\u2019 experiences of care, in particular by improving patient\u2010practitioner communication. Implications for care and research are outlined.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23493","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T16:49:59Z","timestamp":1513442999000},"page":"1335-1347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Unmet Needs of Aboriginal Australians With Musculoskeletal Pain: A Mixed\u2010Method Systematic Review"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6901-2569","authenticated-orcid":false,"given":"Ivan B.","family":"Lin","sequence":"first","affiliation":[{"name":"University of Western Australia Geraldton Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Bunzli","sequence":"additional","affiliation":[{"name":"University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna B.","family":"Mak","sequence":"additional","affiliation":[{"name":"University of Notre Dame Australia School of Medicine Fremantle Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charmaine","family":"Green","sequence":"additional","affiliation":[{"name":"University of Western Australia Geraldton Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Goucke","sequence":"additional","affiliation":[{"name":"Sir Charles Gardner Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli","family":"Coffin","sequence":"additional","affiliation":[{"name":"University of Notre Dame Australia Broome Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204428"},{"key":"e_1_2_7_3_1","volume-title":"National health priority areas","author":"Department of Health and Ageing","year":"2006"},{"key":"e_1_2_7_4_1","volume-title":"Australia's health 2016: Australia's health series no. 15","author":"Australian Institute of Health and Welfare","year":"2016"},{"key":"e_1_2_7_5_1","volume-title":"General practice activity in Australia 2013\u201314. 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Many preclinical models of late effects have been developed that use a single, high dose of radiotherapy, which does not mimic the fractionated schedule children receive clinically. This study aimed to create a mouse model of late effects using clinically-relevant fractionated radiotherapy, and to measure the effects on the developing brain. Juvenile mice were treated at postnatal day 16 with a single dose of 8Gy whole brain radiation, or a mathematically-equivalent fractionated dose of 18Gy (9 x 2Gy daily fractions). Sham control mice received a CT scan, or 9 x sham CT scans. Mice were allowed to grow to young adulthood (63 days). Ex vivo anatomical MRI scans were performed along with diffusion tensor imaging (DTI) and histology. Mice receiving a single 8Gy radiation dose exhibited significantly decreased volumes in areas including the olfactory bulbs (-19%), hippocampus (-7%), corpus callosum (-9%) and motor cortex (-9%). In contrast, mice receiving fractionated radiotherapy showed fewer significantly decreased regions, although olfactory bulbs were reduced (-12%). Furthermore, doublecortin-positive cells were significantly reduced in the dentate gyrus indicating profound effects of radiotherapy on murine neural stem cells. Few radiotherapy-induced differences were observed by DTI, and immunohistochemistry revealed no changes in myelin basic protein, suggesting that white matter is minimally altered in mice. These results show that preclinical models exhibit treatment-induced late effects, and that commonly-used experimental approaches of single dose radiotherapy induce more neurological changes than an equivalent fractionated dose, thus may over-estimate radiotherapy-induced late effects. We have developed a clinically-relevant fractionated dosing protocol in mice, which replicates late effects experienced by children, and can be used to measure long-term effects of novel chemo\/radiotherapy treatment combinations, ensuring children with brain cancer receive treatment both effective and safe treatment.<\/jats:p>","DOI":"10.1093\/neuonc\/noac079.661","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T12:10:19Z","timestamp":1654258219000},"page":"i177-i178","source":"Crossref","is-referenced-by-count":0,"title":["RONC-07. Fractionated radiotherapy is required to accurately mimic neurostructural late effects in preclinical models"],"prefix":"10.1093","volume":"24","author":[{"given":"Jacqueline","family":"Whitehouse","sequence":"first","affiliation":[{"name":"Telethon Kids Institute , Perth , Australia"},{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meegan","family":"Howlett","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute , Perth , Australia"},{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Buck","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute , Perth , Australia"},{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kale","family":"Somers","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Lawler","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Hii","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke","family":"Carline","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mani","family":"Kuchibhotla","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhedita","family":"Sewoo","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"},{"name":"Perron Institute for Neurological and Translational Sciences , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Rosenow","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk","family":"Feindel","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Ebert","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"},{"name":"Sir Charles Gairdner Hospital , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Mehnert","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"},{"name":"Lions Eye Institute , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Gottardo","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute , Perth , Australia"},{"name":"Perth Children's Hospital , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raelene","family":"Endersby","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute , Perth , Australia"},{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,6,3]]},"container-title":["Neuro-Oncology"],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/24\/Supplement_1\/i177\/43945672\/noac079.661.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/24\/Supplement_1\/i177\/43945672\/noac079.661.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T12:10:19Z","timestamp":1654258219000},"score":7.6346245,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article\/24\/Supplement_1\/i177\/6601079"}},"issued":{"date-parts":[[2022,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2022,6,3]]},"published-print":{"date-parts":[[2022,6,3]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noac079.661","ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"published-other":{"date-parts":[[2022,6,1]]},"published":{"date-parts":[[2022,6,1]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:24Z","timestamp":1753890024112,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Microvascular blood flow (MBF) enables the delivery of key nutrients (e.g., lipids and glucose) and hormones (e.g., insulin) to adipose tissue. We have demonstrated that adipose tissue MBF is impaired in people with type 2 diabetes (T2D), postprandially. Whether this also occurs in people at risk of T2D (having a family history of T2D) is unknown. Eighteen healthy people with no family history of T2D for two generations (FH-), and sixteen healthy people with at least one parent with T2D (FH+) were recruited. Overnight-fasted participants had a blood sample taken for clinical chemistries, a DEXA scan performed for body composition and underwent a mixed meal challenge (MMC, 300kCal; 54% carbohydrate, 29% protein and 16% fat). Microvascular blood volume (MBV), velocity (\u03b2) and MBF in truncal subcutaneous adipose tissue was assessed by contrast-enhanced ultrasound before and 60 min post-MMC. Both groups were matched for age, BMI, clinical chemistries and post-MMC area under the glucose time curve (Table 1). FH+ had higher truncal fat (Table 1). Increases in adipose tissue MBF post-MMC were lower in FH+ which was mostly attributed to a lower MBV (Table 1). Despite having normal clinical chemistries and blood glucose regulation, FH+ have impaired post-prandial adipose tissue MBF coinciding with greater central obesity which might in part explain their heightened risk for developing T2D.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n K. Roberts-Thomson: None. R.D. Russell: None. D. Hu: None. T.M. Greenaway: Advisory Panel; Self; Eli Lilly and Company. Speaker\u2019s Bureau; Self; AstraZeneca, Sanofi-Aventis. A.C. Betik: None. L. Parker: None. S.M. Richards: None. D. Premilovac: None. M. Keske: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-1715-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:48Z","timestamp":1592238588000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1715-P: Impaired Postprandial Adipose Tissue Microvascular Blood Flow in Healthy People with a Family History of Type 2 Diabetes"],"prefix":"10.2337","volume":"69","author":[{"given":"KATHERINE","family":"ROBERTS-THOMSON","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Brownsville, TX, Hobart, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RYAN D.","family":"RUSSELL","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Brownsville, TX, Hobart, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DONGHUA","family":"HU","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Brownsville, TX, Hobart, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIMOTHY M.","family":"GREENAWAY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Brownsville, TX, Hobart, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREW C.","family":"BETIK","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Brownsville, TX, Hobart, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEWAN","family":"PARKER","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Brownsville, TX, Hobart, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN M.","family":"RICHARDS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Brownsville, TX, Hobart, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DINO","family":"PREMILOVAC","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Brownsville, TX, Hobart, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHELLE","family":"KESKE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Brownsville, TX, Hobart, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1715-P\/56211\/1715-P-Impaired-Postprandial-Adipose-Tissue","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1715-P\/56211\/1715-P-Impaired-Postprandial-Adipose-Tissue","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:27:55Z","timestamp":1647163675000},"score":7.6344156,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/1715-P\/56211\/1715-P-Impaired-Postprandial-Adipose-Tissue"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-1715-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"1715-P"},{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T04:17:22Z","timestamp":1750306642134,"version":"3.41.0"},"publisher-location":"New 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Nash","sequence":"additional","affiliation":[{"name":"RMIT University Australia, Melbourne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steph","family":"Hutchison","sequence":"additional","affiliation":[{"name":"Deakin University Australia, Burwood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Vincs","sequence":"additional","affiliation":[{"name":"Deakin University Australia, Burwood, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeid","family":"Nahavandi","sequence":"additional","affiliation":[{"name":"Deakin University Australia, Warun Ponds, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Creighton","sequence":"additional","affiliation":[{"name":"Deakin University Australia, Warun Ponds, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"320","published-online":{"date-parts":[[2014,4,9]]},"reference":[{"key":"e_1_3_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1145\/1073204.1073315"},{"key":"e_1_3_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1145\/1553374.1553505"},{"key":"e_1_3_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/11840930_92"},{"key":"e_1_3_2_1_4_1","first-page":"10","volume":"2006","author":"Son K. H.","journal-title":"WIT Transaction on Biomedicine and Health"},{"key":"e_1_3_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patrec.2009.09.009"},{"key":"e_1_3_2_1_6_1","doi-asserted-by":"crossref","unstructured":"Kohonen T. 1997 Self-organizing maps 2nd ed Springer Berlin New York. Kohonen T. 1997 Self-organizing maps 2nd ed Springer Berlin New York.","DOI":"10.1007\/978-3-642-97966-8"},{"volume-title":"ISEA2013","author":"McCormick J.","key":"e_1_3_2_1_7_1"},{"key":"e_1_3_2_1_8_1","unstructured":"Bourke P. 1994 Polygonising a Scalar Field http:\/\/paulbourke.net\/geometry\/polygonise\/ (accessed December 13 2013) Bourke P. 1994 Polygonising a Scalar Field http:\/\/paulbourke.net\/geometry\/polygonise\/ (accessed December 13 2013)"}],"event":{"name":"VRIC '14: Virtual Reality International Conference - Laval Virtual 2014","sponsor":["Laval Virtual Laval Virtual"],"location":"Laval France","acronym":"VRIC '14"},"container-title":["Proceedings of the 2014 Virtual Reality International Conference"],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/2617841.2620707","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/2617841.2620707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T06:56:00Z","timestamp":1750229760000},"score":7.634292,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/2617841.2620707"}},"subtitle":["combining human interaction and a digital performing agent"],"issued":{"date-parts":[[2014,4,9]]},"references-count":8,"alternative-id":["10.1145\/2617841.2620707","10.1145\/2617841"],"URL":"https:\/\/doi.org\/10.1145\/2617841.2620707","published":{"date-parts":[[2014,4,9]]},"assertion":[{"value":"2014-04-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T11:21:17Z","timestamp":1722943277891},"reference-count":0,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"Supplement 2","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JGO"],"published-print":{"date-parts":[[2018,10,1]]},"abstract":" Background and context: Cancer survival rates in Australia are among the best in the world, yet Aboriginal and Torres Strait Islander (indigenous) people continue to experience disparities in the distribution and burden of cancer, and unwarranted variations in outcomes. Indigenous Australians are 40% more likely to die of cancer than non-Indigenous Australians. Cancer Australia developed the National Aboriginal and Torres Strait Islander Cancer Framework (the framework), which identified 7 national priorities to address disparities in cancer outcomes experienced by indigenous Australians. An ongoing collaboration with indigenous Australians was integral to developing this shared agenda. Priority 5 in the framework highlights the need to ensure indigenous Australians affected by cancer receive optimal and culturally appropriate treatment, services, and supportive and palliative care. Aim: To improve cancer outcomes for indigenous Australians through the development and national endorsement of a population-specific Optimal Care Pathway (OCP) to guide the delivery of consistent, safe, high-quality, culturally appropriate and evidence-based care. Strategy\/Tactics: Cancer Australia formed a partnership with the Victorian Department of Health and Human Services (DHHS) to address Priority 5 and develop the OCP. The approach to development was underpinned by Cancer Australia's Model of Engagement for Aboriginal and Torres Strait Islander People and guided by the national Leadership Group on Aboriginal and Torres Strait Islander Cancer Control (Leadership Group). Program\/Policy process: Cancer Australia, in collaboration with DHHS: \u2022 reviewed experiences of care and the framework's comprehensive evidence base \u2022 developed a draft OCP to complement tumor-specific pathways \u2022 facilitated an Expert Working Group, comprising indigenous health sector leaders and consumers to refine and validate the draft OCP \u2022 undertook national public consultation, including with the indigenous health sector and community, health professionals and professional colleges \u2022 received an indication of support to proceed to endorsement from the Leadership Group. Outcomes: The first population-specific OCP for Aboriginal and Torres Strait Islander people with cancer received national endorsement. It will guide the delivery of consistent, safe, high-quality, culturally appropriate and evidence-based care. What was learned: Key elements of optimal care include: addressing the cultural appropriateness of the healthcare environment; improving cross-cultural communication; relationship building with local community; optimizing health literacy; recognition of men's and women's business; and the need to use culturally appropriate resources. The national priority in the framework informed and unified high-level direction, which was integral to effective OCP development and endorsement. The evidence-based, step-wise development approach contributed to its relevance, utility and quality. <\/jats:p>","DOI":"10.1200\/jgo.18.97700","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T20:13:40Z","timestamp":1538165620000},"page":"243s-243s","update-policy":"http:\/\/dx.doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["A National Priority: Improving Outcomes for Aboriginal and Torres Strait Islander People With Cancer Through an Optimal Care Pathway"],"prefix":"10.1200","volume":"4","author":[{"given":"J.","family":"Chynoweth","sequence":"first","affiliation":[{"name":"Cancer Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Daveson","sequence":"additional","affiliation":[{"name":"Cancer Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"McCambridge","sequence":"additional","affiliation":[{"name":"Cancer Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Coutts","sequence":"additional","affiliation":[{"name":"Cancer Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Zorbas","sequence":"additional","affiliation":[{"name":"Cancer Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Whitfield","sequence":"additional","affiliation":[{"name":"Department of Health and Human Services Victoria, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Cancer Australia's Leadership Group on Aboriginal and Torres Strait Islander Cancer Control","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","container-title":["Journal of Global Oncology"],"language":"en","link":[{"URL":"http:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/jgo.18.97700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T08:29:43Z","timestamp":1653812983000},"score":7.633824,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/jgo.18.97700"}},"issued":{"date-parts":[[2018,10,1]]},"references-count":0,"journal-issue":{"issue":"Supplement 2","published-print":{"date-parts":[[2018,10,1]]}},"alternative-id":["10.1200\/jgo.18.97700"],"URL":"https:\/\/doi.org\/10.1200\/jgo.18.97700","ISSN":["2378-9506"],"issn-type":[{"type":"electronic","value":"2378-9506"}],"published":{"date-parts":[[2018,10,1]]},"assertion":[{"value":"2018-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T04:09:45Z","timestamp":1745381385368,"version":"3.40.4"},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"8_Supplement_1","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,4,21]]},"abstract":"\n Background:<\/jats:title>\n Neoadjuvant therapy followed by surgery is the current standard for stage III melanoma, but 60% of patients achieve a major pathological response (MPR) with good long-term outcomes. This raises the potential for modifying treatment strategies to identify patients who may safely omit surgery. Biomarkers such as circulating tumor DNA (ctDNA) and imaging modalities have shown promise in assessing therapeutic response, yet each has limitations when used independently. This study evaluates the relationship between ctDNA clearance and changes in fluorodeoxyglucose(FDG)-positron emission tomography(PET) SUVmax from pre-treatment to pre-surgery, to predict pathological response and the feasibility of non-surgical management in appropriately selected patients.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n In the discovery cohort, plasma ctDNA levels and computed tomography (CT) RECIST data were retrospectively analyzed in stage III melanoma patients from the OpACIN-neo trial (N=9), where two doses of neoadjuvant combination immunotherapy was administered. For validation, FDG-PET SUVmax changes and ctDNA dynamics will be assessed in two trial cohorts: NeoTrio (N=45, pembrolizumab \u00b1 dabrafenib and trametinib) and NeoPele (N=20, pembrolizumab and Lenvatinib). PET responses will be categorized into complete metabolic response (CMR), near-CMR (SUVmax reduction &gt;90%), partial metabolic response (PMR), stable metabolic disease (SMD), and progressive metabolic disease (PMD).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n In the OpACIN-neo cohort, 7\/9 (78%) patients achieved ctDNA clearance pre-surgery and RECIST partial response, with five achieving MPR and two non-MPR. Two patients with persistent ctDNA pre-surgery, which cleared post-surgery, had RECIST stable disease (one achieved MPR and one non-MPR). None of these nine patients experienced clinical recurrence. Preliminary data from the validation cohort shows that all eight patients (8\/33; 24%) with CMR or near CMR achieved MPR, while 5\/6 (83%) patients with PMD were pathological non-responders. CT RECIST was useful in evaluating disease burden in the discovery cohort; however, PET imaging is expected to provide greater specificity and stronger correlation with pathological outcomes. Furthermore, ctDNA clearance has demonstrated potential in identifying patients who may avoid surgery and remain recurrence-free, highlighting the complementary value of both modalities.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Combining ctDNA dynamics with FDG-PET SUVmax changes can improve the prediction of pathological response to neoadjuvant therapy in stage III melanoma. This integrated approach could help identify patients who will achieve durable responses and can safely avoid surgery, supporting the development of more personalized treatment strategies.<\/jats:p>\n <\/jats:sec>\n \n Citation Format:<\/jats:title>\n Wei Yen Chan, Li Zhou, Edward Hsiao, Jenny H. Lee, Ashleigh Stewart, Russell J. Diefenbach, George Au-Yeung, Maria Gonzalez, Andrew J. Spillane, Robyn P. Saw, Sydney Ch'Ng, Matteo Carlino, Richard A. Scolyer, Alexander M. Menzies, Georgina V. Long, Helen Rizos. Integrating ctDNA and FDG-PET dynamics to predict pathological response following neoadjuvant systemic therapy in stage III melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 731.<\/jats:p>\n <\/jats:sec>","DOI":"10.1158\/1538-7445.am2025-731","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T04:55:41Z","timestamp":1745297741000},"page":"731-731","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 731: Integrating ctDNA and FDG-PET dynamics to predict pathological response following neoadjuvant systemic therapy in stage III melanoma"],"prefix":"10.1158","volume":"85","author":[{"given":"Wei Yen","family":"Chan","sequence":"first","affiliation":[{"name":"1Macquarie University, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"2Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Hsiao","sequence":"additional","affiliation":[{"name":"3Royal North Shore Hospital, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny H.","family":"Lee","sequence":"additional","affiliation":[{"name":"1Macquarie University, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashleigh","family":"Stewart","sequence":"additional","affiliation":[{"name":"1Macquarie University, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell J.","family":"Diefenbach","sequence":"additional","affiliation":[{"name":"1Macquarie University, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Au-Yeung","sequence":"additional","affiliation":[{"name":"4Peter MacCallum Cancer Centre, Melbourne, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"2Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Spillane","sequence":"additional","affiliation":[{"name":"2Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn P.","family":"Saw","sequence":"additional","affiliation":[{"name":"2Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney","family":"Ch'Ng","sequence":"additional","affiliation":[{"name":"2Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Carlino","sequence":"additional","affiliation":[{"name":"2Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Scolyer","sequence":"additional","affiliation":[{"name":"2Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander M.","family":"Menzies","sequence":"additional","affiliation":[{"name":"2Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina V.","family":"Long","sequence":"additional","affiliation":[{"name":"2Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Rizos","sequence":"additional","affiliation":[{"name":"1Macquarie University, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/85\/8_Supplement_1\/731\/755125\/Abstract-731-Integrating-ctDNA-and-FDG-PET","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/85\/8_Supplement_1\/731\/755125\/Abstract-731-Integrating-ctDNA-and-FDG-PET","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T04:55:41Z","timestamp":1745297741000},"score":7.6336083,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/85\/8_Supplement_1\/731\/755125\/Abstract-731-Integrating-ctDNA-and-FDG-PET"}},"issued":{"date-parts":[[2025,4,21]]},"references-count":0,"journal-issue":{"issue":"8_Supplement_1","published-print":{"date-parts":[[2025,4,21]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2025-731","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2025,4,21]]}},{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:17:18Z","timestamp":1788898638089,"version":"build-2803163510"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: The REGENT-1 trial evaluated the Re-Cellularization via Electroporation Therapy (ReCET\u2122) System, which uses pulsed electric fields (PEF) to regenerate duodenal mucosa and submucosa. We examined the effect of ReCET\u2122 across energy dose cohorts on CGM metrics.<\/jats:p>\n Methods: REGENT-1studied endoscopic PEF therapy at three doses in T2D adults on 1-4 non-insulin agents. Group 1) Gen 1 catheter 600V, single treatment (n=12); Group 2) Gen 1 catheter, 600V, double treatment (n=18); and Group 3) Gen 2 catheter (increased treated surface area [TSA]), double treatment 750V (n=21). CGM data were collected using Guardian 3 (Medtronic)<\/jats:p>\n Results: Fifty-one participants (mean age 52.9 years, BMI 31.4 kg\/m\u00b2, HbA1c 8.7% [72\u00b19mmol\/mol]) underwent PEF therapy. A dose-response effect was evident, with Group 3 yielding the greatest benefit in day and night glucose levels and reduced glycemic variability. Improvements in Group 3 CGM metrics emerged by week 4, peaked by week 24, and were sustained through week 48 (Figure 1). Double treatment with Gen 1 (Group 2) results were intermediate between Groups 1 and 3.<\/jats:p>\n Conclusion: ReCET\u2122 treatment was followed by a dose dependent improvement in glycemia. Benefits at the highest dose appeared by week 4 and were durable. Findings highlight PEF-induced duodenal regeneration as a promising approach to improve glycemic control in T2D<\/jats:p>\n \n \n Disclosure<\/jats:title>\n D.N. O'Neal: None. J. Apostolopoulos: None. A. Sartoretto: Research Support; Endogenex. Advisory Panel; Bariatek. Research Support; Erbe Elektromedizin GmbH. Consultant; Boston Scientific Corporation. Speaker's Bureau; Menarini. S. Chandran: None. R. Vaughan: None. B. Holt: None. G. Cameron: None. B. AbuDayyeh: Other Relationship; Endogenex. Consultant; Boston Scientific Corporation, Metronics, Olympus. R.E. Pratley: Consultant; AbbVie Inc. Stock\/Shareholder; Altanine, Inc. Consultant; Amgen Inc, AstraZeneca. Other Relationship; Bayer AG, Bayer Pharmaceuticals, Inc, Biomea Fusion. Consultant; Boehringer-Ingelheim. Other Relationship; Carmot Therapeutics, Inc, Corcept Therapeutics, Domp\u00e9, Eli Lilly and Company, Endogenex. Consultant; Endogenex. Other Relationship; Fractyl Health, Inc., Gasherbrum Bio, Inc. Consultant; Genprex, Getz Pharma, Hanmi Pharm. Co., Ltd, Intas Pharmaceuticals Ltd, Lexicon Pharmaceuticals, Inc, Lilly USA LLC. Speaker's Bureau; Lilly USA LLC. Other Relationship; Metavention, Novo Nordisk, Novo Nordisk. Speaker's Bureau; Novo Nordisk. Other Relationship; Pfizer Inc, Poxel SA. Consultant; Regeneron Pharmaceuticals. Other Relationship; Sanofi. Consultant; Scholar Rock. Other Relationship; Sun Pharmaceutical Industries Ltd. C.H. Sorli: Employee; Endogenex. E.I. Ekinci: Research Support; Amgen Inc, Novo Nordisk, Lilly Diabetes, AstraZeneca, Endogenex, Versanis. Advisory Panel; Lilly Diabetes, Novo Nordisk.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-892-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:07:53Z","timestamp":1749791273000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["892-P: Impact of ReCET Therapy on Continuous Glucose Monitoring (CGM) Metrics in Type 2 Diabetes\u2014Insights from the REGENT-1 Trial"],"prefix":"10.2337","volume":"74","author":[{"given":"DAVID N.","family":"O'NEAL","sequence":"first","affiliation":[{"name":"Fitzroy, Australia, Parkville, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOHN","family":"APOSTOLOPOULOS","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Parkville, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ADRIAN","family":"SARTORETTO","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Parkville, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUJIEVVAN","family":"CHANDRAN","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Parkville, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RHYS","family":"VAUGHAN","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Parkville, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BRONTE","family":"HOLT","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Parkville, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GEORGINA","family":"CAMERON","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Parkville, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BARHAM","family":"ABUDAYYEH","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Parkville, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RICHARD E.","family":"PRATLEY","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Parkville, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTOPHER H.","family":"SORLI","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Parkville, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ELIF I.","family":"EKINCI","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Parkville, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/892-P\/158437\/892-P-Impact-of-ReCET-Therapy-on-Continuous","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/892-P\/158437\/892-P-Impact-of-ReCET-Therapy-on-Continuous","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T15:37:27Z","timestamp":1750433847000},"score":7.6335745,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/892-P\/158437\/892-P-Impact-of-ReCET-Therapy-on-Continuous"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-892-p","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"892-P"},{"indexed":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T05:15:35Z","timestamp":1678511735024},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Supplement 4","content-domain":{"domain":["www.auajournals.org"],"crossmark-restriction":true},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1097\/01.ju.0000557197.00725.bd","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T05:40:57Z","timestamp":1556084457000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["MP74-12\u2003PATIENT SELECTION FOR PROSTATE BIOPSY USING A MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING (MPMRI) BASED TRIAGE PATHWAY: FEASIBILITY, PERFORMANCE IN AN ACADEMIC, TERTIARY CENTER"],"prefix":"10.1097","volume":"201","author":[{"given":"Matthew","family":"Roberts*","sequence":"first","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Donato","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Morton","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"Coughlin","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Esler","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel","family":"Dunglison","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Gardiner","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Yaxley","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"http:\/\/www.auajournals.org\/doi\/pdf\/10.1097\/01.JU.0000557197.00725.bd","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T16:48:50Z","timestamp":1678466930000},"score":7.633382,"resource":{"primary":{"URL":"http:\/\/www.auajournals.org\/doi\/10.1097\/01.JU.0000557197.00725.bd"}},"issued":{"date-parts":[[2019,4]]},"references-count":0,"journal-issue":{"issue":"Supplement 4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1097\/01.JU.0000557197.00725.bd"],"URL":"https:\/\/doi.org\/10.1097\/01.ju.0000557197.00725.bd","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"2019-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:35:48Z","timestamp":1753889748031,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Poor wound healing in diabetes is associated with increased chronic inflammation and alterations in macrophage accumulation. Chronic inflammation can alter the phenotype of macrophage precursors, monocytes but whether their phenotype is changed in association with wound healing is not known. Blood was obtained from 21 patients (14 male: 7 female) attending the High Risk Foot Clinic at RPA Hospital at their initial visit (V1), week 4 (V2) and week 8 (V3). Wound area was measured and wound type was assessed by a podiatrist. Monocyte number (CD14+), phenotype as classical (CD16\u2212), non-classical (CD16++), and intermediate (CD16+), anti-inflammatory (CD163+) subset and expression of receptors CCR2, CCR5 and TLR2, TLR4 were determined by flow cytometry. The MMPs and TIMP-1 were measured in plasma by zymography and ELISA. Over the 8 weeks, 6 ulcers healed (H) and 15 failed to heal (NH). The age, duration of diabetes, HbA1c, wound size and duration at V1 were not different between the groups but the % CD16++ monocytes was higher in H vs. NH at V1 (23.5 vs. 8.3) and V3 (17.4 vs. 7.2) and monocyte CCR2+ was lower in H at V3 (P&lt;0.05). Interestingly plasma MMP-3 and MMP-9\/TIMP-1 ratio were higher in H at V1 but MMP-9 was lower in H at V3 (P&lt;0.05). The wound area at V1 was not associated with wound closure rate (WCR: r=0.39, P=0.08). However for all samples at V2+V3, the WCR correlated with monocyte %CD16++ (r=0.42), CD16+ (r=0.39), CD163+ (r=0.37), and CD14+ (r=-0.39), CD16- (r=-0.52), as well as plasma MMP-2 (r=-0.67) and MMP-9 (r=-0.41)(P&lt;0.05). At either V2 or V3, the relationship was maintained for monocyte %CD16++and CD16- and plasma MMP-2 (P&lt;0.05). These results in people with diabetic foot ulcers suggest that circulating monocyte phenotype is altered as the wound heals. The positive relationship in WCR with monocyte anti-inflammatory profile suggests a predictive role for these markers. Whether the transition of monocytes from a pro- to an anti-inflammatory phenotype plays a mechanistic role in wound healing remains to be elucidated.<\/jats:p>\n \n Disclosure<\/jats:title>\n D. Min: None. V.L. Nube: None. A. Tao: None. X. Yuan: None. B. Brooks: None. J. Wong: Speaker's Bureau; Self; Novo Nordisk A\/S, AstraZeneca, Eli Lilly and Company. S.M. Twigg: Advisory Panel; Self; Abbott. Consultant; Self; Abbott. Advisory Panel; Self; Novo Nordisk Inc., Sanofi-Aventis, AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company. Speaker's Bureau; Self; AstraZeneca, Merck Sharp & Dohme Corp.. Other Relationship; Self; Abbott. S. McLennan: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-1736-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:32Z","timestamp":1529693852000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Change in Circulating Monocyte Profile with Foot Ulcer Healing in Diabetic Patients"],"prefix":"10.2337","volume":"67","author":[{"given":"DANQING","family":"MIN","sequence":"first","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VANESSA L.","family":"NUBE","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANH","family":"TAO","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIN","family":"YUAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BELINDA","family":"BROOKS","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENCIA","family":"WONG","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN M.","family":"TWIGG","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUSAN","family":"MCLENNAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1736-P\/54457\/Change-in-Circulating-Monocyte-Profile-with-Foot","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1736-P\/54457\/Change-in-Circulating-Monocyte-Profile-with-Foot","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T10:42:18Z","timestamp":1652697738000},"score":7.633382,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1736-P\/54457\/Change-in-Circulating-Monocyte-Profile-with-Foot"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-1736-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"1736-P"},{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T02:26:52Z","timestamp":1779416812683,"version":"3.53.1"},"reference-count":0,"publisher":"Clinical Exercise Physiology Association","issue":"s2","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2026,4]]},"abstract":"\n BACKGROUND:<\/jats:title>\n Adult Adolescent Idiopathic Scoliosis (AIS) involves post-skeletal maturity scoliosis that persists or progresses, often causing postural imbalance, muscular deconditioning, and reduced trunk muscle endurance. Diminished trunk extensor and abdominal endurance can lead to pain, functional limits, and lower quality of life. Physiotherapeutic Scoliosis-Specific Exercises (PSSE) may address these issues via active self-correction and stabilization. ScoliBalance\u00ae, a PSSE-based program, combines 3D postural correction with progressive endurance and functional training. The impact on trunk muscle endurance in adults with AIS is currently unknown.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVE:<\/jats:title>\n To evaluate changes in trunk muscle endurance in adults with adolescent idiopathic scoliosis following participation in a ScoliBalance\u00ae PSSE program as a single therapeutic intervention.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n This is a retrospective, consecutive case series examining 13 adults (11 females, mean age 29.8 \u00b1 13.8 years) with idiopathic scoliosis who completed an individualized ScoliBalance\u00ae program (PSSE principles: 3D active self-correction, postural stabilization, and integration into activities of daily living). The program included initial one-on-one clinical sessions and a daily home exercise program. Trunk extensor (TE) and abdominal endurance (AE) were assessed at baseline and after 45.8 \u00b1 19.4 months using standardized clinical tests, recorded as duration (s: seconds) maintained (max 240 s).<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n Mean TE statistically significantly increased 31.7% (32.1 s), from 101.2 \u00b1 57.3 s at baseline to 133.3 \u00b1 57.7 s at follow-up (t(12) = -2.41, p = 0.016, Cohen\u2019s d = -0.67). Of note, 7 participants increased scores (range: 20 - 129 s), 3 did not change and 3 had lower scores (range: -2 - -39 s). Mean AE also statistically significantly increased 13% (20.5 s), from 157.8 \u00b1 73.9 s at baseline to 178.3 \u00b1 63.9 s at follow-up (t(12) = -1.72, p = 0.056, Cohen\u2019s d = -0.48). Of note, 8 participants increased scores (range: 15 \u2013 75 s), 3 had no change and 2 had lower scores (range: -13 - -91 s).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n In this cohort of adults with idiopathic scoliosis, participation in a ScoliBalance\u00ae PSSE program was associated with overall improvements in TE and AE, despite isolated cases of reduced or unchanged performance. These preliminary findings support the clinical implementation of the ScoliBalance\u00ae PSSE as a non-surgical strategy for adult AIS demonstrating potential benefits in postural stability and functional capacity. Larger prospective studies are warranted to further investigate long-term endurance adaptations and their relationship to pain, function and curve behavior for the adults with scoliosis.<\/jats:p>\n <\/jats:sec>","DOI":"10.31189\/2165-7629-15-s2.257","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:59:20Z","timestamp":1777341560000},"page":"257","source":"Crossref","is-referenced-by-count":0,"title":["SCOLIBALANCE\u00ae PHYSIOTHERAPEUTIC SCOLIOSIS-SPECIFIC EXERCISE PROTOCOL FOR ADULTS: A CASE SERIES ASSESSING EFFECTS ON TRUNK MUSCLE ENDURANCE"],"prefix":"10.31189","volume":"15","author":[{"given":"Rosemary","family":"Mirenzi","sequence":"first","affiliation":[{"name":"ScoliCare Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora -Lee","family":"Doueihi","sequence":"additional","affiliation":[{"name":"ScoliCare Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Oakley","sequence":"additional","affiliation":[{"name":"ScoliCare Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeb","family":"McAviney","sequence":"additional","affiliation":[{"name":"ScoliCare Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16145","container-title":["Journal of Clinical Exercise Physiology"],"link":[{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/15\/s2\/article-p257-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/15\/s2\/article-p257-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/15\/s2\/article-p257-s.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T01:51:55Z","timestamp":1779414715000},"score":7.633382,"resource":{"primary":{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/15\/s2\/article-p257-s.xml"}},"issued":{"date-parts":[[2026,4]]},"references-count":0,"journal-issue":{"issue":"s2"},"URL":"https:\/\/doi.org\/10.31189\/2165-7629-15-s2.257","ISSN":["2165-7629","2165-6193"],"issn-type":[{"value":"2165-7629","type":"electronic"},{"value":"2165-6193","type":"print"}],"published":{"date-parts":[[2026,4]]}},{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:07:57Z","timestamp":1778735277923,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n To assess the prevalence, clinical features and treatment of otitis media (OM) among Aboriginal children in the Kimberley region of Western Australia, and to determine if a correlation exists between OM and protracted bacterial bronchitis (PBB).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Data was extracted from clinic records of Aboriginal children from four remote Kimberley communities participating in a whole\u2010population lung health screening program during 2018\u20132019. Records were retrospectively reviewed 3\u2009months before and after the screening date. OM prevalence and related complications were determined. Management was assessed against regional guidelines. The relationship between OM and the presence of PBB was assessed using chi\u2010square testing.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n One\u2010hundred ninety\u2010one children (median age 3.5\u2009years, 48.7% female) were included. Otorrhoea and\/or otalgia was documented in 14.1% of children, and 53.9% had abnormal otoscopy findings. Earwax obscured visualisation of the tympanic membrane in 31.4% of examinations. Audiometry was performed in 27.2% of children, with hearing loss detected in 46.1% of those tested. OM, including acute OM with or without perforation, OM with effusion, or chronic suppurative OM, was diagnosed in 43.5% of children. Adherence to guideline\u2010recommended antibiotic route and duration was seen in 15.8% of children with acute OM. No association was found between OM and PBB.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Despite the absence of a relationship between OM and PBB, there is a high burden of OM among Aboriginal children in the Kimberley. Training clinicians in earwax removal and improving eardrum visualisation may enhance detection and timely treatment of OM, improving ear health disparities among Aboriginal populations.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jpc.70346","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:23:39Z","timestamp":1772958219000},"page":"778-785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Understanding Otitis Media Among Aboriginal Children in the Kimberley Region of Western Australia: An Opportunity to Improve Health Outcomes"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3365-7670","authenticated-orcid":false,"given":"Aryan","family":"Kalra","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Perth Children's Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4892-1285","authenticated-orcid":false,"given":"Gloria","family":"Lau","sequence":"additional","affiliation":[{"name":"Wal\u2010Yan Respiratory Research Centre The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"Department of Respiratory and Sleep Medicine Perth Children's Hospital Perth Western Australia Australia"},{"name":"Medical School, the University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9799-0471","authenticated-orcid":false,"given":"Pamela","family":"Laird","sequence":"additional","affiliation":[{"name":"Wal\u2010Yan Respiratory Research Centre The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"Physiotherapy Department Perth Children's Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Jacky","sequence":"additional","affiliation":[{"name":"Wal\u2010Yan Respiratory Research Centre The Kids Research Institute Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soleil","family":"White","sequence":"additional","affiliation":[{"name":"Broome Regional Aboriginal Medical Service (BRAMS) Broome Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azizah","family":"Roe","sequence":"additional","affiliation":[{"name":"Hearing Australia Geraldton Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Cooper","sequence":"additional","affiliation":[{"name":"Medical School, the University of Western Australia Perth Western Australia Australia"},{"name":"The Kids Research Institute Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2000-8910","authenticated-orcid":false,"given":"Andre","family":"Schultz","sequence":"additional","affiliation":[{"name":"Wal\u2010Yan Respiratory Research Centre The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"Department of Respiratory and Sleep Medicine Perth Children's Hospital Perth Western Australia Australia"},{"name":"Medical School, the University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jafri","family":"Kuthubutheen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Perth Children's Hospital Perth Western Australia Australia"},{"name":"Medical School, the University of Western Australia Perth Western Australia Australia"},{"name":"Western Australia Country Health Service Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3180621177"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00248-2019"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50953"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.13757"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02139-2016"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.27318"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/03946320100230S102"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08287-w"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.02.040"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2016.05.011"},{"key":"e_1_2_10_12_1","unstructured":"WHO\/CIBA Foundation Workshop \u201cPrevention of Hearing Impairment From Chronic Otitis Media \u201dWHO\/PDH\/98.4. 1996. London CIBA Foundation 19\u201011\u20101996."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.16626"},{"key":"e_1_2_10_14_1","unstructured":"ABS \u201c2021 Kimberley Census Aboriginal and\/or Torres Strait Islander People QuickStats [Internet]. Australian Government\u2014Australian Bureau of Statistics; 2021 [Cited 2025 Mar 26] \u201dhttps:\/\/www.abs.gov.au\/census\/find\u2010census\u2010data\/quickstats\/2021\/IQS51001."},{"key":"e_1_2_10_15_1","unstructured":"KAHPF \u201cKimberley Aboriginal Health Planning Forum Clinical Guidelines [Internet]. Kimberley Aboriginal Health Planning Forum; 2024 [Cited 2025 Mar 26] \u201dhttps:\/\/kahpf.org.au\/clinical\u2010protocols."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-019-4750-5"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-020-05462-5"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-5-27"},{"key":"e_1_2_10_19_1","unstructured":"Otitis Media \u201cOtitis Media Guidelines: Centre of Research Excellence in Ear and Hearing Health of Aboriginal and Torres Strait Islander Children [Internet]. Menzies School of Health Research; 2021 [Cited 2025 Mar 26] \u201dhttps:\/\/otitismediaguidelines.com\/about\u2010otitis\u2010media\/."},{"key":"e_1_2_10_20_1","unstructured":"Australian Institute of Health and Welfare \u201cNorthern Territory Remote Aboriginal Investment: Ear and Hearing Health Program. July 2012 to June 2016 [Internet]. Australian Government\u2014Australian Institute of Health and Welfare; 2017 [Cited 2025 Mar 26] \u201dhttps:\/\/www.aihw.gov.au\/getmedia\/534d2d41\u20106c74\u20104c14\u2010b4bb\u20109bd49f5edf2b\/20659.pdf?v=20230605181417&inline=true."},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.52100"},{"key":"#cr-split#-e_1_2_10_22_1.1","unstructured":"Australian Bureau of Statistics \"National Aboriginal and Torres Strait Islander Health Survey 2018\u201019 Financial Year [Internet] Australian Bureau of Statistics"},{"key":"#cr-split#-e_1_2_10_22_1.2","unstructured":"2019 [Cited 2025 Mar 26] \"https:\/\/www.abs.gov.au\/statistics\/people\/aboriginal\u2010and\u2010torres\u2010strait\u2010islander\u2010peoples\/national\u2010aboriginal\u2010and\u2010torres\u2010strait\u2010islander\u2010health\u2010survey\/2018\u201019#data\u2010downloads."},{"key":"#cr-split#-e_1_2_10_23_1.1","unstructured":"Australian Bureau of Statistics \"National Health Survey: First Results 2017\u201018 Financial Year [Internet] Australian Bureau of Statistics"},{"key":"#cr-split#-e_1_2_10_23_1.2","unstructured":"2018 [Cited 2025 Mar 26] \"https:\/\/www.abs.gov.au\/statistics\/health\/health\u2010conditions\u2010and\u2010risks\/national\u2010health\u2010survey\/2017\u201018."},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.14560"}],"container-title":["Journal of Paediatrics and Child Health"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.70346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.70346","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.70346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:13:19Z","timestamp":1778731999000},"score":7.6333113,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.70346"}},"issued":{"date-parts":[[2026,3,6]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/jpc.70346"],"URL":"https:\/\/doi.org\/10.1111\/jpc.70346","archive":["Portico"],"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"published":{"date-parts":[[2026,3,6]]},"assertion":[{"value":"2025-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:34:45Z","timestamp":1762522485755},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"16_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,8,15]]},"abstract":"Abstract<\/jats:title>\n Introduction: Checkpoint blockade immunotherapy has revolutionized melanoma treatment. However, immune related adverse events (irAEs) are frequent, particularly when PD-1 and CTLA-4 blocking antibodies are combined. There is an urgent need for biomarkers to predict response as well as toxicity. The intestinal microbiome influences immune processes throughout the body and is therefore hypothesised to influence both immunotherapy response and well as development of irAEs.<\/jats:p>\n Methods: This study utilized sequencing to profile the fecal microbiome from Stage III melanoma patients (n= 38) treated with combination anti-PD1 and anti-CTLA4 antibodies in the neoadjuvant setting (OpacinNeo Trial; NCT02977052) at Melanoma Institute Australia. Absolute bacterial loads were determined with qPCR. Global microbial gene abundance was determined through metagenomic sequencing, allowing analysis of microbial metabolic capcity, and actual short chain fatty acid output (butyrate, acetate, propionate) was assessed by NMR. Matched PBMC were profiled in detail using mass cytometry and immune populations were correlated with microbial metrics. We tested the ability of machine learning to predict therapeutic response and irAEs from microbial data.<\/jats:p>\n Results: Patients who failed to respond (n=6), and those who developed severe (G3-G5) irAEs (n=11), had low microbial diversity before treatment (p=0.0234 and p=0.0226 respectively). Four of the six non-responders in this cohort failed to complete treatment and received immunosuppression before pathologic assessment of response, because of the development of severe irAEs. Thus, non-response may, in fact, have been a consequence of irAE development in those cases. High pre-treatment loads of Ruminococcaceae and methanogenic archaea, and greater relative abundance of butyrate production pathways, were significantly associated with response and protection from irAEs. Patients who had low bacterial diversity had increased proportions of effector and memory CD4 and CD8 T cells in the blood and increased numbers of circulating MAIT, NK and gdT cells prior to immunotherapy. Importantly, microbial taxa were predictive of patients who subsequently failed to respond to therapy while also developing severe irAEs with overall accuracy of 92.1%.<\/jats:p>\n Conclusions: A gut ecosystem enriched with beneficial microbial functions including production of butyrate is associated with protection from irAEs with neoadjuvant combination immunotherapy. The findings allow prediction of outcomes with combination immunotherapy and will inform development of therapeutic microbial interventions.<\/jats:p>\n Citation Format: Marcel Batten, Erin Shanahan, Rebecca Simpson, Mark Read, Ines P. Silva, Alexandra Angelatos, Jian Tan, Chandra Adhikari, Alexander M. Menzies, Robyn P. Saw, Laurence Macia, Maria Gonzalez, Kerwin Shannon, Rebecca Velickovic, Irene L. Reijers, Christian U. Blank, James S. Wilmott, Andrew J. Holmes, Richard A. Scolyer, Georgina V. Long. Gut microbiota predicts response and toxicity with neoadjuvant immunotherapy [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 5734.<\/jats:p>","DOI":"10.1158\/1538-7445.am2020-5734","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T01:39:05Z","timestamp":1599183545000},"page":"5734-5734","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Abstract 5734: Gut microbiota predicts response and toxicity with neoadjuvant immunotherapy"],"prefix":"10.1158","volume":"80","author":[{"given":"Marcel","family":"Batten","sequence":"first","affiliation":[{"name":"1Melanoma Insitute Australia, Camperdown, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Shanahan","sequence":"additional","affiliation":[{"name":"2University of Sydney, Camperdown, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Simpson","sequence":"additional","affiliation":[{"name":"2University of Sydney, Camperdown, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Read","sequence":"additional","affiliation":[{"name":"2University of Sydney, Camperdown, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines P.","family":"Silva","sequence":"additional","affiliation":[{"name":"1Melanoma Insitute Australia, Camperdown, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Angelatos","sequence":"additional","affiliation":[{"name":"2University of Sydney, Camperdown, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Tan","sequence":"additional","affiliation":[{"name":"2University of Sydney, Camperdown, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra","family":"Adhikari","sequence":"additional","affiliation":[{"name":"1Melanoma Insitute Australia, Camperdown, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander M.","family":"Menzies","sequence":"additional","affiliation":[{"name":"3Melanoma Insitute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn P.","family":"Saw","sequence":"additional","affiliation":[{"name":"3Melanoma Insitute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Macia","sequence":"additional","affiliation":[{"name":"2University of Sydney, Camperdown, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"3Melanoma Insitute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerwin","family":"Shannon","sequence":"additional","affiliation":[{"name":"3Melanoma Insitute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Velickovic","sequence":"additional","affiliation":[{"name":"1Melanoma Insitute Australia, Camperdown, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene L.","family":"Reijers","sequence":"additional","affiliation":[{"name":"4Netherlands Cancer Institute, Amsterdam, Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian U.","family":"Blank","sequence":"additional","affiliation":[{"name":"4Netherlands Cancer Institute, Amsterdam, Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Wilmott","sequence":"additional","affiliation":[{"name":"1Melanoma Insitute Australia, Camperdown, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Holmes","sequence":"additional","affiliation":[{"name":"2University of Sydney, Camperdown, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Scolyer","sequence":"additional","affiliation":[{"name":"1Melanoma Insitute Australia, Camperdown, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina V.","family":"Long","sequence":"additional","affiliation":[{"name":"1Melanoma Insitute Australia, Camperdown, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/80\/16_Supplement\/5734\/644168\/Abstract-5734-Gut-microbiota-predicts-response-and","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/80\/16_Supplement\/5734\/644168\/Abstract-5734-Gut-microbiota-predicts-response-and","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T06:04:26Z","timestamp":1655877866000},"score":7.633076,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/80\/16_Supplement\/5734\/644168\/Abstract-5734-Gut-microbiota-predicts-response-and"}},"issued":{"date-parts":[[2020,8,15]]},"references-count":0,"journal-issue":{"issue":"16_Supplement","published-print":{"date-parts":[[2020,8,15]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2020-5734","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2020,8,15]]}},{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:34:18Z","timestamp":1759815258168,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T00:00:00Z","timestamp":1691884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2023,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The applicability of the vital signs prompting medical emergency response (MER) activation has not previously been examined specifically in a large general surgical cohort. This study aimed to characterize the distribution, and predictive performance, of four vital signs selected based on Australian guidelines (oxygen saturation, respiratory rate, systolic blood pressure and heart rate); with those of the MER activation criteria.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective cohort study was conducted including patients admitted under general surgical services of two hospitals in South Australia over 2\u2009years. Likelihood ratios for patients meeting MER activation criteria, or a vital sign in the most extreme 1% for general surgery inpatients (<0.5th percentile or\u2009>\u200999.5th percentile), were calculated to predict in\u2010hospital mortality.<\/jats:p><\/jats:sec>Results<\/jats:title>15\u2009969 inpatient admissions were included comprising 2\u2009254\u2009617 total vital sign observations. The 0.5th and 99.5th centile for heart rate was 48 and 133, systolic blood pressure 85 and 184, respiratory rate 10 and 31, and oxygen saturations 89% and 100%, respectively. MER activation criteria with the highest positive likelihood ratio for in\u2010hospital mortality were heart rate\u2009\u2264\u200939 (37.65, 95% CI 27.71\u201349.51), respiratory rate\u2009\u2265\u200931 (15.79, 95% CI 12.82\u201319.07), and respiratory rate\u2009\u2264\u20097 (10.53, 95% CI 6.79\u201314.84). These MER activation criteria likelihood ratios were similar to those derived when applying a threshold of the most extreme 1% of vital signs.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This study demonstrated that vital signs within Australian guidelines, and escalation to MER activation, appropriately predict in\u2010hospital mortality in a large cohort of patients admitted to general surgical services in South Australia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18648","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T03:54:07Z","timestamp":1691985247000},"page":"2426-2432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vital signs and medical emergency response (MER) activation predict in\u2010hospital mortality in general surgery patients: a study of 15 969 admissions"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3880-3840","authenticated-orcid":false,"given":"Joshua G.","family":"Kovoor","sequence":"first","affiliation":[{"name":"University of Adelaide, Discipline of Surgery The Queen Elizabeth Hospital Adelaide South Australia Australia"},{"name":"Royal Australasian College of Surgeons Adelaide South Australia Australia"},{"name":"Health and Information Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Bacchi","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Flinders Medical Centre Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-3489","authenticated-orcid":false,"given":"Brandon","family":"Stretton","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-0378","authenticated-orcid":false,"given":"Aashray K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Gold Coast University Hospital Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Lam","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Jiang","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane","family":"Lee","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh\u2010Son","family":"To","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"Flinders Medical Centre Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8075-7852","authenticated-orcid":false,"given":"Christopher D.","family":"Ovenden","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-4554","authenticated-orcid":false,"given":"Joseph N.","family":"Hewitt","sequence":"additional","affiliation":[{"name":"University of Adelaide, Discipline of Surgery The Queen Elizabeth Hospital Adelaide South Australia Australia"},{"name":"Health and Information Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudy","family":"Goh","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Gluck","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8066-7259","authenticated-orcid":false,"given":"Jessica L.","family":"Reid","sequence":"additional","affiliation":[{"name":"University of Adelaide, Discipline of Surgery The Queen Elizabeth Hospital Adelaide South Australia 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However, data are limited.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n To compare the outcomes of surveillance versus non\u2010surveillance in patients with PSC.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective cohort of patients with PSC at a liver transplant hospital with hepatologist\u2010directed MRCP surveillance were identified. The surveillance group underwent a MRCP every 12 \u00b1\u20093 months for at least 70% of the follow\u2010up period. Patients were followed from their first MRCP to cholangiocarcinoma diagnosis, liver transplantation, death or the 30 April 2023.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The surveillance group with 108 patients (68%) and non\u2010surveillance group with 50 patients (32%) were similar at baseline, with the median age at PSC diagnosis 38\u2009years (range: 7\u201378\u2009years), 91 males (59%) and the median duration of MRCP surveillance 86 months (range: 10\u2013257 months). Cholangiocarcinoma was diagnosed in 14 patients (9%) (intrahepatic,\n n<\/jats:italic>\n =\u200910; extrahepatic,\n n<\/jats:italic>\n =\u20094). Surveillance MRCP detected one cholangiocarcinoma of the six patients diagnosed in the surveillance cohort, while 10 patients were diagnosed with cholangiocarcinoma following symptoms or raised liver enzymes. Overall, cumulative survival at 3 and 5 years was significantly improved in the surveillance group compared with the non\u2010surveillance group in multivariate models, adjusting for age, cirrhosis and presence of cholangiocarcinoma (97% vs 77%, and 94% vs 69%, respectively;\n P<\/jats:italic>\n <\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n MRCP surveillance did not detect early cholangiocarcinoma or improve cholangiocarcinoma survival in this retrospective cohort of PSC patients; however, surveillance was associated with improved overall survival compared to no surveillance.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/imj.70435","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T15:43:33Z","timestamp":1775922213000},"page":"1026-1032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Annual magnetic resonance cholangiopancreatography surveillance 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However, there is a considerable challenge in evaluating learners' skill acquisition, with most of the past research relying on pre\u2010 and post\u2010tests or other forms of self\u2010reports to measure leadership development. In that sense, these approaches measure leadership development before and after the programme, while being inefficient for measuring the development during the learning process. This study collected self\u2010reflection answers from a professional development MOOC that allows learners to express their stepwise learning and reflect on their professional experience on leadership fronts. We developed a novel methodology and an automated system for the evaluation of leadership skills' mastery based on the depth of reflection exhibited during the learning process. We identified four groups of learners based on their course content mastery and explored the differences within groups. The results also highlight relevant insights about instructional design and provide promising avenues for future research.<\/jats:p>\n <\/jats:sec>\n \n \n \n \n \n Practitioner notes<\/jats:title>\n <\/jats:caption>\n What is already known about this topic<\/jats:p>\n \n \n \n Professional leadership programmes have become increasingly common in workplace learning.<\/jats:p>\n <\/jats:list-item>\n \n Programmes mainly use manual\/introspective measures to assess skill acquisition.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n What this paper adds<\/jats:p>\n \n \n \n An automated assessment system to evaluate leadership skill mastery.<\/jats:p>\n <\/jats:list-item>\n \n Evidence\u2010based and leadership driven inferences about skill acquisition.<\/jats:p>\n <\/jats:list-item>\n \n Use of a novel multidisciplinary methodology for complex skills assessment.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n Implications of practice and\/or policy<\/jats:p>\n \n \n \n Assessing leadership development should include more than course grades.<\/jats:p>\n <\/jats:list-item>\n \n Assessing differences in content mastery requires evaluation of various skills.<\/jats:p>\n <\/jats:list-item>\n \n Developed assessment system provides promise for other similar domains.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bjet.13218","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:05:06Z","timestamp":1648760706000},"page":"1842-1863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Measuring leadership development in workplace learning using automated assessments: Learning analytics and measurement theory approach"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2437-6892","authenticated-orcid":false,"given":"Abhinava","family":"Barthakur","sequence":"first","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9694-6033","authenticated-orcid":false,"given":"Vitomir","family":"Kovanovic","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6999-3547","authenticated-orcid":false,"given":"Srecko","family":"Joksimovic","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"The University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Richey","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"},{"name":"The Boeing Company Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-0582","authenticated-orcid":false,"given":"Abelardo","family":"Pardo","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Mining login data for actionable student insight","author":"Agnihotri L.","year":"2015"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbspro.2015.01.424"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1108\/00251740910966695"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1109\/TLT.2022.3162546"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chb.2020.106674"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.18608\/hla17.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1548051809339193"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hrm.21669"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1108\/00251740510609974"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-65368-6"},{"key":"e_1_2_11_12_1","volume-title":"Annual meeting of the National Council on Measurement in Education, Vancouver, British Columbia, Canada","author":"Close C. 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Accessed April 2013. http:\/\/www.nrcan.gc.ca\/energy\/sources\/crude\/2114."},{"key":"2025122723352326000_R20"},{"key":"2025122723352326000_R21","first-page":"53","article-title":"An updated stratigraphic framework for the Georgina Basin, Northern Territory and Queensland.","author":"Smith","year":"2013","journal-title":"The APPEA Journal"}],"container-title":["The APPEA Journal"],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/53\/2\/472\/915277\/aj12083.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/53\/2\/472\/915277\/aj12083.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T04:35:28Z","timestamp":1766896528000},"score":7.630673,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/ep\/article\/53\/2\/472\/115042\/Unconventional-hydrocarbons-Australia-s-old-rocks"}},"issued":{"date-parts":[[2013,6,30]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,6,30]]}},"URL":"https:\/\/doi.org\/10.1071\/aj12083","ISSN":["1326-4966","2206-8996"],"issn-type":[{"type":"print","value":"1326-4966"},{"type":"electronic","value":"2206-8996"}],"published":{"date-parts":[[2013,6,30]]}},{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:54:03Z","timestamp":1759694043699,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Retinopathy increases with duration of diabetes but the presence of this microvascular complication in individual patients remains unpredictable. Retinal neurophysiological changes have been postulated to be important in modulating susceptibility. We performed electroretinography (ERG) on patients with long duration of diabetes (&gt;15 years) but no retinopathy to determine whether this setting of \u201cnormal retinal morphology\u201d is also characterised by normal electrophysiology of the eyes. ERG was performed with a handheld RETeval-DR\u2122 device. Flickering lights at 30Hz was used to stimulate retinal electrical activity recorded by skin electrodes placed below the lower eye lids. Implicit time (electrical conduction time, msec), amplitude (uV) and pupil diameter (mm) were recorded. A composite score &lt; 20 of these three parameters indicates a &lt;1% risk of vision threatening retinopathy. Altogether 26 type 2 and 9 type 1 patients with no retinopathy and diabetes duration 22.5\u00b14.5 and 32.8\u00b19.4 years respectively were studied. Nondiabetic individuals (fasting BGL&lt;6.0mM or HbA1c&lt;6.0% n=25) acted as controls. Results in Table 1 showed the implicit time of individuals with diabetes but no retinopathy was only minimally increased but the amplitude was significantly reduced by \u223c30% (p&lt;0.01). We conclude that the eyes of these patients protected from diabetic retinopathy nevertheless showed retinal neural dysfunction.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n B. Brooks: None. D. Yue: None. E. Landy: None. Y. Shi: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-593-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:35Z","timestamp":1529693855000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["Abnormal Electroretinography in Patients with Long-Duration Diabetes but No Retinopathy"],"prefix":"10.2337","volume":"67","author":[{"given":"BELINDA","family":"BROOKS","sequence":"first","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DENNIS","family":"YUE","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELLEN","family":"LANDY","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YI","family":"SHI","sequence":"additional","affiliation":[{"name":"Camperdown, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/593-P\/60690\/Abnormal-Electroretinography-in-Patients-with-Long","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/593-P\/60690\/Abnormal-Electroretinography-in-Patients-with-Long","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:14:50Z","timestamp":1647166490000},"score":7.630673,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/593-P\/60690\/Abnormal-Electroretinography-in-Patients-with-Long"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-593-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"593-P"},{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:54:57Z","timestamp":1784238897615,"version":"3.55.0"},"reference-count":52,"publisher":"American Speech Language Hearing Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["LSHSS"],"published-print":{"date-parts":[[2022,10,6]]},"abstract":"Purpose:<\/jats:title>Children who are Deaf and Hard of Hearing (DHH), their parents, Teachers of the Deaf, and other community stakeholders were involved in co-designing a web-based resource to support students' social\u2013emotional well-being. The resource was designed to provide families and teachers with strategies to enhance the social and emotional well-being of Grade 4\u20136 students who are DHH. This study reports outcomes of a pilot study of the web-based resource intervention.<\/jats:p><\/jats:sec>Method:<\/jats:title>A pre\u2013post pilot study was conducted to quantitatively examine reported anxiety, well-being, social relationships, school experience, student\u2013teacher relationship, and parent and teacher self-efficacy. A total of 37 students, their parents (n<\/jats:italic>= 37), and their classroom teachers (n<\/jats:italic>= 40) participated in the intervention program and were provided access to the resource.<\/jats:p><\/jats:sec>Results:<\/jats:title>In total, 19 students, 22 parents, and 17 teachers completed both pre- and postsurvey measures. Pairedt<\/jats:italic>tests revealed that there was a statistically significant increase in parents' self-efficacy scores from pre- to posttest. Multivariate analysis of covariance revealed a significant association between parent use of the website and student-reported improved peer support and reduced school loneliness. No other statistically significant differences were found.<\/jats:p><\/jats:sec>Conclusions:<\/jats:title>The use of a web-based resource codeveloped with students who are DHH, their parents, and teachers could potentially be beneficial for the well-being of students who are DHH as well as parents' self-efficacy. Further research is needed to confirm the benefits.<\/jats:p><\/jats:sec>","DOI":"10.1044\/2022_lshss-21-00178","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T17:57:11Z","timestamp":1659376631000},"page":"1037-1050","source":"Crossref","is-referenced-by-count":6,"title":["Supporting the Social\u2013Emotional Well-Being of Elementary School Students Who Are Deaf and Hard of Hearing: A Pilot Study"],"prefix":"10.1044","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3233-9757","authenticated-orcid":false,"given":"Yuriko","family":"Kishida","sequence":"first","affiliation":[{"name":"Telethon Kids Institute, Perth, Western Australia, Australia"},{"name":"Telethon Speech & Hearing, Perth, Western Australia, Australia"},{"name":"Macquarie University, Sydney, New South Wales, Australia"},{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7216-8097","authenticated-orcid":false,"given":"Christopher G.","family":"Brennan-Jones","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth, Western Australia, Australia"},{"name":"Curtin University, Perth, Western Australia, Australia"},{"name":"Perth Children's Hospital, Child and Adolescent Health Service, Western Australia, Australia"},{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8770-8743","authenticated-orcid":false,"given":"Kevin","family":"Runions","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth, Western Australia, Australia"},{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rena","family":"Vithiatharan","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6213-2488","authenticated-orcid":false,"given":"Kirsten","family":"Hancock","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Education, School of Special Education Needs: Sensory, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2911-5381","authenticated-orcid":false,"given":"Robert H.","family":"Eikelboom","sequence":"additional","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"},{"name":"The University of Western Australia, Perth, Australia"},{"name":"Ear Science Institute, Perth, Western Australia, Australia"},{"name":"Department of Speech-Language Pathology and Audiology, University of Pretoria, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli","family":"Coffin","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth, Western Australia, Australia"},{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Kickett-Tucker","sequence":"additional","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1438-8830","authenticated-orcid":false,"given":"Ian W.","family":"Li","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Epstein","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Falconer","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6217-5058","authenticated-orcid":false,"given":"Donna","family":"Cross","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth, Western Australia, Australia"},{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1310","reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.058222"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cch.12661"},{"issue":"1","key":"e_1_3_2_4_1","first-page":"73","article-title":"Beliefs and self-efficacy of parents of young children with hearing loss","volume":"5","author":"Ambrose S. 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Deafness and hearing loss. https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/deafness-and-hearing-loss"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/deafed\/enu017"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/deafed\/enw103"}],"container-title":["Language, Speech, and Hearing Services in Schools"],"language":"en","link":[{"URL":"http:\/\/pubs.asha.org\/doi\/pdf\/10.1044\/2022_LSHSS-21-00178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T12:21:15Z","timestamp":1727698875000},"score":7.630651,"resource":{"primary":{"URL":"http:\/\/pubs.asha.org\/doi\/10.1044\/2022_LSHSS-21-00178"}},"issued":{"date-parts":[[2022,10,6]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10,6]]}},"alternative-id":["10.1044\/2022_LSHSS-21-00178"],"URL":"https:\/\/doi.org\/10.1044\/2022_lshss-21-00178","ISSN":["0161-1461","1558-9129"],"issn-type":[{"value":"0161-1461","type":"print"},{"value":"1558-9129","type":"electronic"}],"published":{"date-parts":[[2022,10,6]]}},{"indexed":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T22:11:03Z","timestamp":1656454263484},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"8_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2012,4,15]]},"abstract":"Abstract<\/jats:title>\n Multidrug resistance is one of the major causes of treatment failure in cancer therapy. While multidrug transporter proteins are known for their contributions to chemoresistance and efflux of anti-cancer drugs from cancer cells, a significant body of evidence points to their fundamental roles in tumour biology (Fletcher et al, Nature Rev Cancer, 10:147-156, 2010). We have investigated the ABCC subfamily of multidrug transporter genes in the highly malignant and aggressive childhood solid tumour, neuroblastoma and found that high levels of ABCC1 and ABCC4 are powerful independent prognostic indicators of clinical outcome. However, the agents used to treat the patients described in these studies are not known substrates of ABCC4 and we have shown that siRNA-mediated knockdown of ABCC4 results in reduced proliferation and enhanced morphological differentiation of neuroblastoma cells, in the absence of any cytotoxic drug treatment (Henderson et al, JNCI, 103;1-16, 2011). The aim of this study is to develop a potential new approach for the treatment of neuroblastoma through the inhibition of ABCC4 using small molecule inhibitors. A cell-based screen of a library of diverse chemical small molecules was used to isolate potent small molecule inhibitors of ABCC4 that were able to sensitize HEK293 cells over-expressing MRP4 to a cytotoxic MRP4 substrate, 6-mercaptopurine (6MP). Filtering of compounds based upon their ability to cause 6MP accumulation, together with focused library screening, have resulted in the identification of several chemical structures able to specifically block MRP4. In addition to reversing drug resistance to 6MP, these compounds cause morphological differentiation and inhibition of cell growth, as seen with MRP4 siRNA, in the BE2C neuroblastoma cell line. Importantly, these compounds significantly potentiate morphological differentiation caused by the established differentiation agent, all-trans retinoic acid. We further show that these inhibitors have potency in other MRP4 expressing cancer cell lines beyond neuroblastoma. These pharmacological inhibitors offer clinical potential for the treatment of neuroblastoma and other MRP4 overexpressing cancers.<\/jats:p>\n Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1834. doi:1538-7445.AM2012-1834<\/jats:p>","DOI":"10.1158\/1538-7445.am2012-1834","type":"journal-article","created":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T22:38:59Z","timestamp":1344551939000},"page":"1834-1834","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 1834: Targeting ABC transporters in cancer through small molecule inhibitors"],"prefix":"10.1158","volume":"72","author":[{"given":"Tony","family":"Huynh","sequence":"first","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Tivnan","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia","family":"Munoz","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanna","family":"Cheung","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anasuya","family":"Vishvanath","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Flemming","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fujiko","family":"Watt","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Burkhart","sequence":"additional","affiliation":[{"name":"2Cleveland Biolabs, Buffalo, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Gudkov","sequence":"additional","affiliation":[{"name":"3Roswell Park Cancer Institute, Buffalo, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Fletcher","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Henderson","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray","family":"Norris","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Haber","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/72\/8_Supplement\/1834\/578733\/Abstract-1834-Targeting-ABC-transporters-in-cancer","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/72\/8_Supplement\/1834\/578733\/Abstract-1834-Targeting-ABC-transporters-in-cancer","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T21:57:17Z","timestamp":1656453437000},"score":7.6305737,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/72\/8_Supplement\/1834\/578733\/Abstract-1834-Targeting-ABC-transporters-in-cancer"}},"issued":{"date-parts":[[2012,4]]},"references-count":0,"journal-issue":{"issue":"8_Supplement","published-print":{"date-parts":[[2012,4,15]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2012-1834","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published-other":{"date-parts":[[2012,4]]},"published":{"date-parts":[[2012,4]]}},{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:03:15Z","timestamp":1787166195734,"version":"build-2736575974"},"reference-count":62,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Background. Many people with Parkinson\u2019s disease (PD) experience cognitive decline. It is not known whether cognitive training or noninvasive brain stimulation are effective at alleviating cognitive deficits in PD. Objective. To examine cognitive training and non-invasive brain stimulation interventions for cognition in PD. Methods. An extensive search was conducted of published and unpublished studies in online databases. Studies were selected if they were controlled trials examining standard (not individualized) or tailored (individualized) cognitive training, repetitive transcranial magnetic stimulation (rTMS), or transcranial direct current stimulation (tDCS) in PD, with outcomes measured by standardized neuropsychological tests. Results. Fourteen controlled trials met inclusion criteria. For executive function, the pooled effect size (Hedges\u2019 g) for cognitive training (standard and tailored combined) was small ( g = 0.42) but statistically significant (95% CI 0.15-0.68). The pooled effect for standard cognitive training (alone) was medium ( g = 0.51) and significant (95% CI 0.16-0.85). For attention\/working memory, small pooled effect sizes were found when combining standard and tailored cognitive training ( g = 0.23; 95% CI 0.02-0.44) and for standard cognitive training alone ( g = 0.29; 95% CI 0.04-0.53), both significant. For memory, small but significant pooled effect sizes were also found when combining standard and tailored cognitive training and for standard cognitive training alone. Conclusions. The results suggest that standard and tailored cognitive training may improve executive function, attention\/working memory, and memory in PD. Future studies must adopt randomized controlled trial designs to explore the therapeutic potential of these interventions.<\/jats:p>","DOI":"10.1177\/1545968317712468","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T01:26:32Z","timestamp":1496712392000},"page":"597-608","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":74,"title":["Cognitive Training and Noninvasive Brain Stimulation for Cognition in Parkinson\u2019s Disease: A Meta-analysis"],"prefix":"10.1177","volume":"31","author":[{"given":"Blake J.","family":"Lawrence","sequence":"first","affiliation":[{"name":"Curtin University, Bentley, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Gasson","sequence":"additional","affiliation":[{"name":"Curtin University, Bentley, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romola S.","family":"Bucks","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakkhina","family":"Troeung","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"},{"name":"The University of Notre Dame Australia, Fremantle, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Loftus","sequence":"additional","affiliation":[{"name":"Curtin University, Bentley, Western Australia, 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Yet, we know little about what effective partnerships look like for parents of autistic children from diverse backgrounds. Using participatory methods, we conducted semi-structured interviews with 15 Somali mothers of autistic children attending Australian kindergartens\/schools to understand experiences of parent\u2013teacher interactions. We used reflexive thematic analysis to identify key themes. We found that mothers were proud and accepting of their children. They had high expectations, particularly around children\u2019s independence. Mothers wished their children\u2019s differences were understood and supported by other people, including teachers. They were frustrated by low expectations of children, a lack of genuine communication from teachers and limited autism-specific knowledge, skills and experience within schools. They described racist attitudes towards their children and reported that they themselves had experienced stigma. They also had few sources of support to rely upon, although their non-autistic daughters and their faith were important foundations for resilience. Despite all of these challenges, mothers themselves were increasing community awareness and knowledge about autism in the hope that they and their children would be valued by others. Our work has implications for how teachers and schools can foster successful relationships with Somali parents of autistic children.<\/jats:p>\n \n Lay abstract<\/jats:title>\n Good relationships between parents and schools can improve autistic children\u2019s school success. There are many reasons why families from different cultural backgrounds find it harder to develop good relationships with schools, such as language barriers, discrimination and unfamiliarity with education systems. We know little about what \u2018good relationships\u2019 look like for these families. Here, we worked with a team of autistic and non-autistic researchers as well as an Advisory Group of Somali parents to conduct interviews with 15 Somali mothers of kindergarten and school-age autistic children. We asked mothers about their experiences of their child\u2019s education, communication with teachers and what a good relationship with schools would look like. We also asked how they felt the Somali community understood autism. We looked for common things that mothers said. We found that mothers were very proud of their children. They had high expectations, particularly about what children could do by themselves. Mothers found it frustrating that teachers had low expectations, that schools were not good at communicating with them and that autism-specific skills and experience were uncommon in schools. They also reported racist attitudes towards their children. Mothers experienced stigma and lacked resources, but support was gained from their daughters and their religion. Mothers themselves were proactively increasing community awareness and knowledge about autism in the hope that they and their autistic children would be valued and better supported. Our work has implications for how teachers and schools can work together with Somali parents to forge better futures for autistic children.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/13623613221146077","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T04:29:37Z","timestamp":1674275377000},"page":"1777-1789","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["\u2018Somali parents feel like they\u2019re on the outer\u2019: Somali mothers\u2019 experiences of parent\u2013teacher relationships for their autistic children"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3528-0658","authenticated-orcid":false,"given":"Jodie","family":"Smith","sequence":"first","affiliation":[{"name":"Macquarie University, Australia"},{"name":"La Trobe University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aspasia Stacey","family":"Rabba","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"},{"name":"La Trobe University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Ali","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poulomee","family":"Datta","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Dresens","sequence":"additional","affiliation":[{"name":"Positive Partnerships, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Faragaab","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"},{"name":"Positive Partnerships, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Hall","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Heyworth","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"},{"name":"Reframing Autism, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadra","family":"Ige","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenn","family":"Lawson","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6143-8805","authenticated-orcid":false,"given":"Rozanna","family":"Lilley","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najeeba","family":"Syeda","sequence":"additional","affiliation":[{"name":"Positive Partnerships, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7246-8003","authenticated-orcid":false,"given":"Elizabeth","family":"Pellicano","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"},{"name":"University College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,21]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"crossref","unstructured":"Aabe N. 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Expression of \u03b2III-tubulin, encoded by the TUBB3 gene, is associated with clinical resistance and aggressive disease in NSCLC1. Herein, we interrogated the mechanistic role of \u03b2III-tubulin in regulating the tumorigenic potential of NSCLC.<\/jats:p>\n METHODS: Functional studies involved independent clones of NSCLC H460 cells stably expressing shRNA targeting \u03b2III-tubulin, H460 controls stably expressing (non-functional) shRNA and \u03b2III-tubulin rescue clones established in our laboratory2. Differential proteomics was conducted using fluorescence based 2D-DIGE and mass spectrometry. Gene and protein expression performed by qRT-PCR and western blotting respectively. To assess effects on tumor growth and incidence we used metastatic (tail vein) and subcutaneous models of NSCLC. Tumors monitored by CT or Xenogen imaging.<\/jats:p>\n RESULTS: Functional and differential proteomics revealed that \u03b2III-tubulin regulates expression of tumor growth- and metastases-associated proteins. In particular, the tumor suppressor maspin, associated with adhesion and metastasis, was differentially regulated by \u03b2III-tubulin. Functionally, \u03b2III-tubulin suppression led to altered cell morphology, increased cell adhesion and increased sensitivity to anoikis. Mechanistically, we identified PTEN and AKT kinase as a key signaling axis mediating anoikis and regulated by \u03b2III-tubulin levels in NSCLC cells. Finally, \u03b2III-tubulin suppression was shown to reduce NSCLC tumor growth and incidence in vivo. Collectively, these data identified \u03b2III-tubulin as a regulator of tumor growth and metastasis through regulation of PTEN and AKT signaling. We conclude that suppressing \u03b2III-tubulin may reduce tumor growth in NSCLC.<\/jats:p>\n SIGNIFICANCE: This is the first study to show that silencing \u03b2III-tubulin alters the expression of proteins involved in promoting tumorigenicity and increases sensitivity to anoikis, leading to reduced tumor incidence. Targeting \u03b2III-tubulin could be a promising strategy for inhibiting tumor growth and metastasis in NSCLC.<\/jats:p>\n 1 Kavallaris, M. Nature Rev Cancer, 10:194-204, 2010<\/jats:p>\n 2 McCarroll et al. Cancer Res 70 :4995-5003, 2010<\/jats:p>\n Citation Format: Joshua A. McCarroll, Pei Pei Gan, Rafael B. Erlich, Marjorie Liu, Tanya Dwarte, Mia C. Akerfeldt, Melissa Chang, Michael S. Shum, Frances Byrne, Maria Kavallaris. \u03b2III-tubulin is required for the tumorigenic phenotype and resistance to anoikis via the PTEN\/AKT signaling axis in non-small cell lung cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2076. doi:10.1158\/1538-7445.AM2014-2076<\/jats:p>","DOI":"10.1158\/1538-7445.am2014-2076","type":"journal-article","created":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T21:52:16Z","timestamp":1430517136000},"page":"2076-2076","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 2076: \u03b2III-tubulin is required for the tumorigenic phenotype and resistance to anoikis via the PTEN\/AKT signaling axis in non-small cell lung cancer"],"prefix":"10.1158","volume":"74","author":[{"given":"Joshua A.","family":"McCarroll","sequence":"first","affiliation":[{"name":"Children's Cancer Institute Australia, Randwick, NSW, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei Pei","family":"Gan","sequence":"additional","affiliation":[{"name":"Children's Cancer Institute Australia, Randwick, NSW, 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Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/74\/19_Supplement\/2076\/593995\/Abstract-2076-III-tubulin-is-required-for-the","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/74\/19_Supplement\/2076\/593995\/Abstract-2076-III-tubulin-is-required-for-the","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T15:59:46Z","timestamp":1656345586000},"score":7.630262,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/74\/19_Supplement\/2076\/593995\/Abstract-2076-III-tubulin-is-required-for-the"}},"issued":{"date-parts":[[2014,10,1]]},"references-count":0,"journal-issue":{"issue":"19_Supplement","published-print":{"date-parts":[[2014,10,1]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2014-2076","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2014,10,1]]}},{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:39:40Z","timestamp":1777714780790,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE 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Australia. The study explored factors related to older people\u2019s (60+ years) participation in community-based activities and links between their participation and levels of social isolation, loneliness, and social connectedness. The research incorporated four interrelated stages: (1) an audit of existing programs in the City and program participant characteristics; (2) focus groups with program participants and interviews with nonparticipants; (3) a cross-sectional survey to assess factors associated with participation and links to social isolation, loneliness, and social connectedness; (4) face-to-face interviews with survey respondents screened at risk for loneliness. Methodological recommendations are provided to guide future collaborative research with local authorities, program developers, and administrators, aimed at minimizing social isolation and loneliness among older people. These include the need for clear communication and documentation of mutually agreed research objectives and responsibilities from project initiation to completion, identifying and working with local agencies to maximize recruitment among \u201chard to reach\u201d groups, understanding the dimensions of loneliness addressed in the selected instrument used to screen for loneliness, and integrating innovative data collection techniques when working with vulnerable groups such as socially isolated older people.<\/jats:p>","DOI":"10.1177\/1609406919872914","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T02:09:26Z","timestamp":1567649366000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Guidance for Research on Social Isolation, Loneliness, and Participation Among Older People: Lessons From a Mixed Methods Study"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2226-4651","authenticated-orcid":false,"given":"Julie","family":"Dare","sequence":"first","affiliation":[{"name":"Edith Cowan University, Joondalup, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Joondalup, Western Australia, Australia"},{"name":"Curtin University, Bentley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Donovan","sequence":"additional","affiliation":[{"name":"University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny","family":"Lo","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Joondalup, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Louise","family":"McDermott","sequence":"additional","affiliation":[{"name":"Diverse Productions, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"City of Belmont, Belmont, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Marquis","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Joondalup, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"bibr1-1609406919872914","doi-asserted-by":"publisher","DOI":"10.1017\/S0144686X10001091"},{"key":"bibr2-1609406919872914","doi-asserted-by":"publisher","DOI":"10.1300\/J074v18n01_05"},{"key":"bibr3-1609406919872914","volume-title":"Australian health survey: Users\u2019 guide, 2011-13","author":"Australian Bureau of Statistics","year":"2013"},{"key":"bibr4-1609406919872914","doi-asserted-by":"publisher","DOI":"10.1177\/1757913914530842"},{"key":"bibr5-1609406919872914","volume-title":"Social research methods","author":"Bryman A.","year":"2012","edition":"4"},{"key":"bibr6-1609406919872914","doi-asserted-by":"publisher","DOI":"10.1016\/j.cities.2016.03.016"},{"key":"bibr7-1609406919872914","doi-asserted-by":"publisher","DOI":"10.1177\/1558689810382916"},{"key":"bibr8-1609406919872914","doi-asserted-by":"publisher","DOI":"10.1017\/S0144686X04002594"},{"key":"bibr9-1609406919872914","doi-asserted-by":"publisher","DOI":"10.1093\/heapro\/dat033"},{"key":"bibr10-1609406919872914","doi-asserted-by":"publisher","DOI":"10.1111\/hsc.12311"},{"key":"bibr11-1609406919872914","volume-title":"Research design: Qualitative, quantitative, and mixed methods approaches","author":"Creswell J. 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What's new?","volume":"39","author":"Soulsby","year":"2009","journal-title":"Intern Med J"},{"key":"2025090221180207000_31.4.301.30","doi-asserted-by":"publisher","DOI":"10.1592\/phco.30.1.95"},{"key":"2025090221180207000_31.4.301.31","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.3.623"},{"key":"2025090221180207000_31.4.301.32","doi-asserted-by":"crossref","DOI":"10.1186\/s12913-019-4508-0","article-title":"Re-energising the way we manage change in healthcare: the case for soft systems methodology and its application to evidence-based practice","volume":"19","author":"Augustsson","year":"2019","journal-title":"BMC Health Serv Res"},{"key":"2025090221180207000_31.4.301.33","doi-asserted-by":"publisher","DOI":"10.1186\/1748-5908-7-50"}],"container-title":["European Journal of Hospital Pharmacy"],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ejhpharm-2022-003545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T04:18:12Z","timestamp":1756873092000},"score":7.629809,"resource":{"primary":{"URL":"https:\/\/ejhp.bmj.com\/lookup\/doi\/10.1136\/ejhpharm-2022-003545"}},"issued":{"date-parts":[[2022,12,20]]},"references-count":33,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,6,21]]},"published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1136\/ejhpharm-2022-003545"],"URL":"https:\/\/doi.org\/10.1136\/ejhpharm-2022-003545","ISSN":["2047-9956","2047-9964"],"issn-type":[{"type":"print","value":"2047-9956"},{"type":"electronic","value":"2047-9964"}],"published":{"date-parts":[[2022,12,20]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:58Z","timestamp":1753890058954,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"Aim: To compare device tolerance & participant\u2019s subjective experience wearing a surgically implanted long term glucose sensor versus conventional CGM in adults with Type 1 Diabetes.<\/jats:p>\n Method: A prototype CGM (Eclipse 3 sensor, GlySens, San Diego, CA) with masked glucose data transmitted to a study iPhone was surgically inserted superficial to the rectus sheath in 8 Adults with Type 1 Diabetes (4 Female; Mean [SD] Age 56 [7]Y; BMI 25[3]). One daily fingerstick glucose calibration was required. Participants simultaneously wore a conventional TGA approved multi-Day sensor that also transmitted unblinded glucose information to the Study iPhone. The two systems were compared using a standardized 5-point Leichardt scale questionnaire completed by participants at day 1, 7 and 14 post-implantation and monthly thereafter for the duration of study participation.<\/jats:p>\n Results: The investigation and comparator sensors were worn 100% and 98% percent of the time respectively over the study duration. Figure 1 summarizes the participant experience.<\/jats:p>\n Conclusions: Over time there was a general trend by all participants to favour the GlySens sensor and experience over the comparator CGM.<\/jats:p>\n .<\/jats:p>\n \n Figure 1: Participant experience over 10 months of sensor implantation.<\/jats:p>\n \n Disclosure<\/jats:title>\n L.Robinson: None. J.Tan: None. S.L.Martha: Employee; GlySens Incorporated. D.N.O'neal: None. V.R.Obeyesekere: None. H.Jones: None. Y.W.Kong: None. C.Yuan: None. K.Bertsch: Employee; GlySens. T.L.Routh: Employee; GlySens Incorporated. C.M.Sims: Stock\/Shareholder; Medtronic. A.Butler: Employee; GlySens Incorporated.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-973-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:04:44Z","timestamp":1687237484000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["973-P: Wearing a Long-Term Implanted Continuous Glucose Monitoring (CGM) System vs. Conventional CGM in Adults with Type 1 Diabetes\u2014The Physical Burden"],"prefix":"10.2337","volume":"72","author":[{"given":"LESLEY","family":"ROBINSON","sequence":"first","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VARUNI R.","family":"OBEYESEKERE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HANNAH","family":"JONES","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YEE W.","family":"KONG","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHENG","family":"YI YUAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KRISTA","family":"BERTSCH","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIMOTHY L.","family":"ROUTH","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CATRIONA M.","family":"SIMS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTHONY","family":"BUTLER","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JASON","family":"TAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SANDRA L.","family":"MARTHA","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/973-P\/149025\/973-P-Wearing-a-Long-Term-Implanted-Continuous","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/973-P\/149025\/973-P-Wearing-a-Long-Term-Implanted-Continuous","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:04:45Z","timestamp":1687237485000},"score":7.629365,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/973-P\/149025\/973-P-Wearing-a-Long-Term-Implanted-Continuous"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-973-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"973-P"},{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T03:00:41Z","timestamp":1771210841875,"version":"3.50.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2003,12,1]]},"abstract":"Abstract<\/jats:title>\n The mechanism by which TPA-induced PKC activity modulates osteoclastogenesis is not clear. Using a RAW264.7 cell culture system and assays for NF-\u03baB nuclear translocation, NF-\u03baB reporter gene activity, and MAPK assays, we demonstrated that TPA inhibits osteoclastogenesis through the suppression of RANKL-induced NF-\u03ba\u03b2 activation.<\/jats:p>\n Introduction: The protein kinase C (PKC) pathway has been suggested to be an important regulator of osteoclastic bone resorption. The role of PKC in RANKL-induced osteoclastogenesis, however, is not clear. In this study, we examined the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA), a PKC activator, on osteoclastogenesis and studied its role in RANKL-induced signaling.<\/jats:p>\n Materials and Methods: RANKL-induced RAW264.7 cell differentiation into osteoclast-like cells was used to assess the effect of TPA on osteoclastogenesis. Assays for NF-\u03baB nuclear translocation, NF-\u03baB reporter gene activity, protein kinase activity, and Western blotting were used to examine the effects of TPA on RANKL-induced NF-\u03ba\u03b2, c-Jun N-terminal kinase (JNK), and MEK\/ERK and p38 signal transduction pathways.<\/jats:p>\n Results: We found that TPA inhibited RANKL-induced RAW264.7 cell differentiation into osteoclasts in a dose-dependent manner. Time course analysis showed that the inhibitory effect of TPA on RANKL-induced osteoclastogenesis occurs predominantly at an early stage of osteoclast differentiation. TPA alone had little effect on NF-\u03ba\u03b2 activation in RAW264.7 cells, but it suppresses the RANKL-induced NF-\u03ba\u03b2 activation in a dose-dependent fashion. Interestingly, the suppressive effect of TPA on RANKL-induced NF-\u03ba\u03b2 activation was prevented by a conventional PKC inhibitor, Go6976. Supershift studies revealed that the RANKL-induced DNA binding of NF-\u03ba\u03b2 complexes consisted of C-Rel, NF-\u03baB1 (p50), and RelA (p65). In addition, TPA induced the activation of JNK in RAW264.7 cells but had little effect on RANKL-induced activation of JNK. TPA also inhibited RANKL-induced activation of ERK but had little effect on p38 activation.<\/jats:p>\n Conclusion: Given that NF-\u03baB activation is obligatory for osteoclast differentiation, our studies imply that inhibition of osteoclastogenesis by TPA is, at least in part, caused by the suppression of RANKL-induced activation of NF-\u03ba\u03b2 during an early stage of osteoclastogenesis. Selective modulation of RANKL signaling pathways by PKC activators may have important therapeutic implications for the treatment of bone diseases associated with enhanced bone resorption.<\/jats:p>","DOI":"10.1359\/jbmr.2003.18.12.2159","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T05:47:03Z","timestamp":1146116823000},"page":"2159-2168","source":"Crossref","is-referenced-by-count":129,"title":["12-O<\/i>-tetradecanoylphorbol-13-acetate (TPA) Inhibits Osteoclastogenesis by Suppressing RANKL-Induced NF-\u03baB Activation"],"prefix":"10.1093","volume":"18","author":[{"given":"Cathy","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, University of Western Australia, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H","family":"Steer","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Western Australia, Nedlands, 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Dental Journal"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The aims of this study were to evaluate the microbiological trends in severe odontogenic infections requiring hospital admission in the South Australian Oral and Maxillofacial Surgery Unit. Rates of antibiotic resistance to empirical antibiotic regimens were determined to quantify the clinical implications of antibiotic\u2010resistant odontogenic infections.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective case audit was performed on all odontogenic infections admitted to the Royal Adelaide Hospital over a 9\u2010year period. Data was collected regarding demographics, microbiological culture and sensitivity results, and clinical outcome variables.<\/jats:p><\/jats:sec>Results<\/jats:title>Of a total of 672 patients, microbiology data was available for 447 cases. Penicillin\u2010resistant organisms were identified in 10.8% of patients, who required a significantly longer length of hospital admission (mean, 9.93\u00a0days) and higher rates of non\u2010response to initial surgical therapy (40%).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>There were moderate rates of antibiotic\u2010resistant odontogenic infections within the South Australian population. Patients within this subgroup demonstrate markedly poorer clinical outcomes. Effective treatment of odontogenic infections involves early operative intervention, with adjunctive use of appropriate antibiotic therapy that involves close monitoring of response to removal of the cause and use of first\u2010line antibiotic agents. 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However, clinical responses are not universal and there is still a substantial gap in understanding the mechanistic insights of immunotherapy resistance. This study aims to better understand patients\u2019 resistance to immune checkpoint therapies by dissecting and tracing individual tumour and immune cell clones.<\/jats:p>\n Methods: Melanoma tumour dissociates and lesion matched formalin-fixed paraffin-embedded tissue samples were collected from patients with advanced melanoma receiving ipilimumab in combination with nivolumab; 2 patients were long-term responders, 2 had innate resistance and 1 acquired resistance. The molecular characteristics and spatial cellular relations associated with tumour and immune subsets in response to treatment were identified using single-cell indexing of transcriptomes and epitopes by sequencing and CODEX (CO-Detection by indEXing) multiplexed tissue imaging. Integration of spatial and molecular information was performed by combining reference-based phenotyping, Louvain clustering, and a mutual nearest neighbours-based transfer learning algorithm.<\/jats:p>\n Results: Pre-treatment melanoma biopsies from 5 patients (3 responding and 2 non-responding) along with a subsequent acquired resistance biopsy from an initially responding patient were analysed. Comparisons of cellular phenotypes identified higher proportions of gamma delta T cells (1.98% versus 0.2%) and enriched memory T cell profiles (CD3E, CD44, CD45RO, CD8) in responding compared to non-responding pre-treatment biopsies. Fibroblast from non-responding lesions overexpressed stromal related cytokine, IL1A (log2 fold change (FC) = 3.3) and CXCL1 (log2 FC = 1.4), which were enrichment at the tumour margin compared to responding lesions. Comparisons of a patient\u2019s pre-treatment biopsy that initially responded to a subsequent progressing biopsy with acquired resistance had altered expression of transcript factor, ZFX (log2 FC = -1.59; adjusted p = 0.0119), and MBD2 (log2 FC = -1.5; adjusted p = 0.0225) within the patient\u2019s memory T-cells.<\/jats:p>\n Conclusion: The combination of high dimensional single cell transcriptomics and spatial tissue imaging are effective tools to identify specific changes in cell phenotypes, intracellular signalling, and spatial location. This analysis identified reduced memory T cells, increased fibroblast, and altered cellular signalling were associated with resistance to immunotherapies.<\/jats:p>\n Citation Format: Camelia Quek, Aditya Pratapa, Ines Pires da Silva, Ghamdan Al-Eryani, Aaron Mayer, Nenad Bartonicek, Kate Harvey, Oliver Braubach, Robyn P.M. Saw, Jonathan Stretch, Kerwin F. Shannon, Alexander M. Menzies, Richard A. Scolyer, Georgina V. Long, Alexander Swarbrick, James S. Wilmott. Distinct spatial and molecular maps in the tumour microenvironment of resistant melanoma patients treated with checkpoint inhibitor immunotherapy. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4621.<\/jats:p>","DOI":"10.1158\/1538-7445.am2023-4621","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T16:42:24Z","timestamp":1686328944000},"page":"4621-4621","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Abstract 4621: Distinct spatial and molecular maps in the tumour microenvironment of resistant melanoma patients treated with checkpoint inhibitor immunotherapy"],"prefix":"10.1158","volume":"83","author":[{"given":"Camelia","family":"Quek","sequence":"first","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Pratapa","sequence":"additional","affiliation":[{"name":"2Akoya Biosciences, California, CA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines Pires","family":"da Silva","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghamdan","family":"Al-Eryani","sequence":"additional","affiliation":[{"name":"3Garvan Institute of Medical Research, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Mayer","sequence":"additional","affiliation":[{"name":"4Stanford University, California, CA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nenad","family":"Bartonicek","sequence":"additional","affiliation":[{"name":"5Melanoma Institute Australia, Garvan Institute of Medical Research, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Harvey","sequence":"additional","affiliation":[{"name":"3Garvan Institute of Medical Research, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Braubach","sequence":"additional","affiliation":[{"name":"2Akoya Biosciences, California, CA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn P.M.","family":"Saw","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Stretch","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerwin F.","family":"Shannon","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander M.","family":"Menzies","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Scolyer","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina V.","family":"Long","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Swarbrick","sequence":"additional","affiliation":[{"name":"3Garvan Institute of Medical Research, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Wilmott","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/83\/7_Supplement\/4621\/720390\/Abstract-4621-Distinct-spatial-and-molecular-maps","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/83\/7_Supplement\/4621\/720390\/Abstract-4621-Distinct-spatial-and-molecular-maps","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T16:42:24Z","timestamp":1686328944000},"score":7.628778,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/83\/7_Supplement\/4621\/720390\/Abstract-4621-Distinct-spatial-and-molecular-maps"}},"issued":{"date-parts":[[2023,4,4]]},"references-count":0,"journal-issue":{"issue":"7_Supplement","published-print":{"date-parts":[[2023,4,4]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2023-4621","ISSN":["1538-7445"],"issn-type":[{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2023,4,4]]}},{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T23:29:28Z","timestamp":1768087768674,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Dementia is currently the second leading cause of death in Australia and the seventh leading cause of death worldwide. Diagnosis of Alzheimer's disease (AD), the major cause of dementia, is difficult and time consuming. Current clinical imaging technologies are costly to use for widespread early screening of AD and have limited availability. In contrast, the retina is unique, where blood vessels and neural tissue can be viewed and imaged non\u2010invasively and relatively inexpensively. As part of the central nervous system, the retina exhibits similarities to the brain and can display indicators of various neurological disorders, including AD. We aimed to image the retina and analyse its spectral features to develop a robust machine learning (ML) classification model that distinguishes between brain amyloid\u2010beta (A\u03b2) positive and negative individuals.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n Sixty\u2010eight consenting volunteers with varying levels of brain A\u03b2 protein underwent non\u2010invasive imaging using a hyperspectral retinal camera and illumination of wavelengths from 450 to 905 nm. Multiple retina features from the central and superior views were selected and analysed to identify their variability among individuals with different brain amyloid loads. Eight ML models were evaluated for their performance in predicting brain A\u03b2 levels using the retina images and systemic factors like age, gender and apolipoprotein E (APOE) genotype.<\/jats:p>\n <\/jats:sec>\n \n Result<\/jats:title>\n The retinal reflectance spectra in the 405\u2013585 nm wavelengths exhibited a significant difference in individuals with increasing brain amyloid. The retinal features in the superior view showed higher inter\u2010subject variability. Our comparison of eight different ML algorithms revealed that the Multi\u2010Layer Perceptron (MLP) model exhibited superior classification performance, achieving an accuracy of 0.86, precision of 0.88, recall of 0.82, F1\u2010score of 0.85, and area under curve (AUC) of 0.90.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study indicates that there are spectral variations of retinal features associated with brain amyloid loads. It also demonstrates the feasibility of the retinal hyperspectral imaging (rHSI) technique as a potential non\u2010invasive, inexpensive screening method to identify individuals in the preclinical phase of AD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz70856_105392","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:14:25Z","timestamp":1768068865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyperspectral Retinal Imaging as a Non\u2010Invasive Technique to Determine Brain Amyloid Status"],"prefix":"10.1002","volume":"21","author":[{"given":"Ralph N","family":"Martins","sequence":"first","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purna","family":"Poudel","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia, Australia"},{"name":"Australian Alzheimer's Research Foundation, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun","family":"Frost","sequence":"additional","affiliation":[{"name":"CSIRO, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun","family":"Eslick","sequence":"additional","affiliation":[{"name":"Macquarie University, Macquarie Park, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid R","family":"Sohrabi","sequence":"additional","affiliation":[{"name":"Murdoch University, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Taddei","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Joondalup, Australia"},{"name":"Alzheimer's Research Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Hone","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia, Australia"},{"name":"Australian Alzheimer's Research Foundation, Perth, Western Australia, Australia"},{"name":"Lions Alzheimer's Foundation, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,10]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz70856_105392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:14:26Z","timestamp":1768068866000},"score":7.628732,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz70856_105392"}},"issued":{"date-parts":[[2025,12]]},"references-count":0,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/alz70856_105392"],"URL":"https:\/\/doi.org\/10.1002\/alz70856_105392","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2026-01-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e105392"},{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:12:49Z","timestamp":1787019169634,"version":"build-2736575974"},"reference-count":68,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T00:00:00Z","timestamp":1712448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Autism"],"published-print":{"date-parts":[[2024,10]]},"abstract":"\n People thrive in compassionate environments. For autistic people, their environments are often non-conducive to care and support. We propose that cultivating autistic people\u2019s self-compassion may be an antidote to the mental health difficulties arising from environmental causes. The current study aimed to pilot a self-guided online self-compassion program for autistic adults to assess its feasibility, acceptability, and outcomes related to completing this program. The program was co-produced with autistic individuals. Thirty-nine autistic adults aged 20\u201377\u2009years ( M\n age<\/jats:sub>\n \u2009=\u200945.28, SD\n age<\/jats:sub>\n \u2009=\u200911.92) completed the online program. They also provided feedback about their self-compassion practices every week. They completed pre- and post-intervention online surveys measuring self-compassion, symptoms of anxiety and depression, positive and negative affect, emotion regulation difficulties, and psychological well-being. As hypothesized, there were significant group improvements in all outcome measures. Preliminary results suggest that the program is feasible and accepted by participants. Approximately half of the autistic participants reported experiences of backdraft, which are adverse reactions associated with self-compassion practices. Based on our findings, we provided clinical recommendations on how self-compassion can be taught to autistic adults.\n <\/jats:p>\n \n Lay abstract<\/jats:title>\n Self-compassion is when we are aware of our feelings and thoughts, are friendly toward ourselves, and realize everyone feels pain and makes mistakes. Self-compassion is associated with having better mental health and well-being in autistic and non-autistic people. But we do not know if autistic people\u2019s self-compassion can be improved through psychoeducation and self-compassion practices. We co-produced an online self-guided self-compassion program based on evidence-based self-compassion practices for autistic adults called the Self-compassion Program for Autistic Adults. This program included live-experiences videos of autistic adults reflecting on their self-compassion and self-critical experiences. This study piloted the program with 39 autistic adults. We wanted to see if these autistic adults\u2019 self-compassion, emotion regulation, mental health, and psychological well-being improved after completing this program. We found that the autistic participants\u2019 self-compassion, emotion regulation, mental health, and psychological well-being improved significantly after completing the program over 5\u2009weeks. We also found that just over half of the participants reported experiencing negative reactions associated with self-compassion practices. We suggested some clinical implications, including a recommendation for emotion regulation interventions to incorporate self-compassion to help promote access to the affiliative system. In addition, autistic adults who are psychologically vulnerable may need to work with mental health professionals while developing self-compassion to help manage the possible negative reactions associated with some self-compassion practices.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/13623613241235061","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T01:07:02Z","timestamp":1712538422000},"page":"2572-2585","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Self-compassion improves emotion regulation and mental health outcomes: A pilot study of an online self-compassion program for autistic adults"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-0495","authenticated-orcid":false,"given":"Ru Ying","family":"Cai","sequence":"first","affiliation":[{"name":"Autism Spectrum Australia, Australia"},{"name":"La Trobe University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Edwards","sequence":"additional","affiliation":[{"name":"Autism Spectrum Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6647-9814","authenticated-orcid":false,"given":"Abigail MA","family":"Love","sequence":"additional","affiliation":[{"name":"Autism Spectrum Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Brown","sequence":"additional","affiliation":[{"name":"La Trobe University, Australia"},{"name":"The University of Melbourne, Australia"},{"name":"Healthscope Hospitals, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-5164","authenticated-orcid":false,"given":"Vicki","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Autism Spectrum Australia, Australia"},{"name":"The University of Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,7]]},"reference":[{"key":"bibr1-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005653411471"},{"key":"bibr2-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.23354"},{"key":"bibr3-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1022-9"},{"key":"bibr4-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1080\/09687599.2020.1822782"},{"key":"bibr5-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-020-01498-0"},{"key":"bibr6-13623613241235061","unstructured":"Cai R. Y. (in press). A commentary on backdraft in self-compassion: An overlooked yet vital research focus. Mindfulness."},{"key":"bibr7-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1089\/aut.2020.0034"},{"key":"bibr8-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-022-05668-y"},{"key":"bibr9-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1089\/aut.2022.0068"},{"key":"bibr10-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1968"},{"key":"bibr11-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-022-01891-x"},{"key":"bibr12-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2019.101422"},{"key":"bibr13-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1002\/cpp.2372"},{"key":"bibr14-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-015-2360-6"},{"key":"bibr15-13623613241235061","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.876990"},{"key":"bibr16-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1111\/papt.12107"},{"key":"bibr17-13623613241235061","doi-asserted-by":"publisher","DOI":"10.2189\/asqu.51.1.59"},{"key":"bibr18-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1177\/13623613241234097"},{"key":"bibr19-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-019-01134-6"},{"key":"bibr20-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.22375"},{"key":"bibr21-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133481"},{"key":"bibr22-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1177\/1362361320909184"},{"key":"bibr23-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1177\/13623613221132109"},{"key":"bibr24-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1177\/13623613221150375"},{"key":"bibr25-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1111\/bjc.12043"},{"key":"bibr26-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1186\/s40639-017-0033-3"},{"key":"bibr27-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1023\/B:JOBA.0000007455.08539.94"},{"key":"bibr28-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1177\/1362361314536937"},{"key":"bibr29-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1007\/s40474-018-0133-6"},{"key":"bibr30-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-010-1073-0"},{"key":"bibr31-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1111\/aphw.12127"},{"key":"bibr32-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-020-01401-x"},{"key":"bibr33-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1093\/clipsy.bpg016"},{"key":"bibr34-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2013.02.001"},{"key":"bibr35-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"bibr36-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00277-1"},{"key":"bibr37-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30289-5"},{"key":"bibr38-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-022-01909-4"},{"key":"bibr39-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2012.06.003"},{"key":"bibr40-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1177\/13623613211067928"},{"key":"bibr41-13623613241235061","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17082829"},{"key":"bibr42-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1007\/s40489-018-00156-5"},{"key":"bibr43-13623613241235061","doi-asserted-by":"publisher","DOI":"10.3138\/jvme.0116-027R1"},{"key":"bibr44-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-021-01766-7"},{"key":"bibr45-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1177\/1362361318824104"},{"key":"bibr46-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20925"},{"key":"bibr47-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1080\/15298860309027"},{"key":"bibr48-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.21923"},{"key":"bibr49-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1037\/pas0000629"},{"key":"bibr50-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1038\/s44159-022-00099-z"},{"key":"bibr51-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-019-01254-z"},{"key":"bibr52-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1177\/17455057221142369"},{"key":"bibr53-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1038\/srep40700"},{"key":"bibr54-13623613241235061","doi-asserted-by":"publisher","DOI":"10.3928\/02793695-20171219-01"},{"key":"bibr55-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1002\/hrdq.21369"},{"key":"bibr56-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2016.05.004"},{"key":"bibr57-13623613241235061","doi-asserted-by":"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R.","year":"2006","journal-title":"Current Psychiatry"},{"key":"bibr64-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.54.6.1063"},{"key":"bibr65-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcbs.2013.09.002"},{"key":"bibr66-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1177\/13623613221136752"},{"key":"bibr67-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1080\/15298868.2015.1029966"},{"key":"bibr68-13623613241235061","doi-asserted-by":"publisher","DOI":"10.1111\/aphw.12051"}],"container-title":["Autism"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13623613241235061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13623613241235061","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13623613241235061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:50:59Z","timestamp":1777380659000},"score":7.628637,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13623613241235061"}},"issued":{"date-parts":[[2024,4,7]]},"references-count":68,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1177\/13623613241235061"],"URL":"https:\/\/doi.org\/10.1177\/13623613241235061","ISSN":["1362-3613","1461-7005"],"issn-type":[{"value":"1362-3613","type":"print"},{"value":"1461-7005","type":"electronic"}],"published":{"date-parts":[[2024,4,7]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:38:03Z","timestamp":1753889883332,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Type 1 diabetes (T1D) is characterized by the loss of insulin-producing beta-cells. We currently lack diagnostic tools to measure T1D progression. Using systematic approaches involving unprejudiced discovery analyses in human tissues and clinical samples, we identify microRNAs that are: i) associated with insulin expression during embryonic development (N&gt;60); ii) predictive of and necessary for insulin transcription (N=698); and iii) dysregulated in individuals with (vs. without) T1D (N=200). Insulin cfDNA (assessed by ddPCR) and microRNA (assessed by TaqMan qPCR) biomarkers were measured in around; i) N=400 Australian T1D individuals; ii) N=30 longitudinal samples from children at risk of T1D; iii) N=100 clinical trial samples from individuals receiving IFN-a or Exenatide vs. placebo; iv) N=400 Hong Kong Chinese individuals with T1D; v) N=700 Danish individuals at diagnosis of T1D and vi) N=400 Asian Indian T1D subjects. Among N=600 Australian samples, we identified miRNAs (N=5) that were significantly increased in the circulation of T1D individuals (vs. controls), decreased (at least 2 Fold Change\/FC, P&lt;0.05, N=7miRNAs) in T1DCx+ vs. T1DCx- (no T1D complications) or significantly increased (2 FC, P&lt;0.05, N=5) in T1D individuals with detectable C-peptide vs. non-detectable C-peptide. Our studies highlight the potential of circulating microRNAs and cfDNA in quantifying beta cell death before clinical diagnosis of T1D. These data demonstrate that microRNA\/cfDNA signatures not only facilitate the potential prediction of diabetes progression, but can also help in stratifying individuals at risk of T1D as well as assess treatment efficacies in trials aiming to retard beta-cell death. We also present our preliminary analysis of cross-ethnic variation in these cfDNA\/miRNA biomarkers and present ongoing\/future studies to develop a diagnostic test for T1D prediction.<\/jats:p>\n \n Disclosure<\/jats:title>\n M. Joglekar: None. R. Farr: None. W. Wong: None. K. Rother: None. A. Jenkins: Research Support; Self; Medtronic, Mylan, Sanofi-Aventis. C.S. Yajnik: None. R.C. Ma: Research Support; Self; AstraZeneca, Bayer AG, Merck Sharp & Dohme Corp., Pfizer Inc.. Advisory Panel; Self; Boehringer Ingelheim GmbH, Nippon Boehringer Ingelheim Co. Ltd.. M.E. Craig: None. T. Jones: None. A. Hardikar: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-231-or","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:33Z","timestamp":1529693853000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Novel MicroRNA and Cell-Free DNA Biomarkers of Beta-Cell Death and Diabetes Progression"],"prefix":"10.2337","volume":"67","author":[{"given":"MUGDHA","family":"JOGLEKAR","sequence":"first","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Bethesda, MD, Pune, India, Hong Kong, China, Westmead, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RYAN","family":"FARR","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Bethesda, MD, Pune, India, Hong Kong, China, Westmead, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WILSON","family":"WONG","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Bethesda, MD, Pune, India, Hong Kong, China, Westmead, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KRISTINA","family":"ROTHER","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Bethesda, MD, Pune, India, Hong Kong, China, Westmead, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Bethesda, MD, Pune, India, Hong Kong, China, Westmead, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHITTARANJAN S.","family":"YAJNIK","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Bethesda, MD, Pune, India, Hong Kong, China, Westmead, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RONALD C.","family":"MA","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Bethesda, MD, Pune, India, Hong Kong, China, Westmead, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA E.","family":"CRAIG","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Bethesda, MD, Pune, India, Hong Kong, China, Westmead, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIM","family":"JONES","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Bethesda, MD, Pune, India, Hong Kong, China, Westmead, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANAND","family":"HARDIKAR","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Geelong, Australia, Bethesda, MD, Pune, India, Hong Kong, China, Westmead, Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"PREDICT T1D STUDY GROUP","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/231-OR\/59310\/Comparison-of-Novel-MicroRNA-and-Cell-Free-DNA","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/231-OR\/59310\/Comparison-of-Novel-MicroRNA-and-Cell-Free-DNA","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:08:01Z","timestamp":1647166081000},"score":7.628543,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/231-OR\/59310\/Comparison-of-Novel-MicroRNA-and-Cell-Free-DNA"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-231-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"231-OR"},{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:04:24Z","timestamp":1770743064475,"version":"3.49.0"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: Diabetic kidney disease (DKD) can progress to end-stage kidney disease, increasing morbidity and mortality. Standard DKD assessment using estimated glomerular filtration rate (eGFR) and urinary albumin:creatinine ratio (ACR) has limitations in early risk prediction. This study compared the Promarker\u00aeD test to eGFR and ACR for predicting kidney function decline over 4 years in adults with type 2 diabetes (T2D).<\/jats:p>\n Methods: Next-generation PromarkerD, optimized for ELISA-based workflows, integrates plasma apolipoprotein A-IV and CD5 antigen-like protein with age and eGFR to generate risk scores (low, moderate, high). The study analyzed data from the Fremantle Diabetes Study (n=948; mean age 65 years, 54% males). The 1\u00b0 endpoint was incident DKD (an eGFR drop to &lt;60 mL\/min\/1.73m\u00b2 or a \u226540% decline from baseline eGFR &lt;60 mL\/min\/1.73m\u00b2). Logistic regression models assessed the association of i) PromarkerD, ii) eGFR, iii) ACR, and iv) eGFR + ACR with the 1\u00b0 outcome. Model performance was evaluated using the area under the curve (AUC).<\/jats:p>\n Results: At baseline, mean eGFR was 82 mL\/min\/1.73m\u00b2, median ACR 2.1 mg\/mmol. PromarkerD classified 65% as low, 24% moderate, and 11% high risk. Over 4.2 years, 11.3% reached the 1\u00b0 endpoint. PromarkerD had superior predictive performance (AUC 0.88) vs. eGFR (0.80), ACR (0.63), and eGFR + ACR (0.81) (P&lt;0.001). Higher PromarkerD scores were more strongly associated with the 1\u00b0 outcome (odds ratio (OR) 3.14, 95% CI 2.60-3.79 per 1 standard deviation (SD) increase) than lower eGFR and higher ACR (OR 2.30 (1.90-2.79) and 1.29 (1.12-1.49) per 1 SD increase, respectively). PromarkerD moderate and high-risk scores were increasingly prognostic (OR 4.52 and 17.87 vs. low risk; P&lt;0.001). PromarkerD remained significantly associated with the 1\u00b0 outcome after adjusting for eGFR and ACR (OR 2.88 (2.31-3.58) per 1 SD increase).<\/jats:p>\n Conclusion: Next-generation PromarkerD more accurately identifies adults with T2D at risk of kidney function decline than current standard of care biochemical tests.<\/jats:p>\n \n Disclosure<\/jats:title>\n K.E. Peters: Employee; Proteomics International. Stock\/Shareholder; Proteomics International. Other Relationship; Proteomics International. S. Bringans: Employee; Proteomics International. Stock\/Shareholder; Proteomics International. Other Relationship; Proteomics International. W.A. Davis: Other Relationship; Proteomics International. R.J. Lipscombe: Employee; Proteomics International. Stock\/Shareholder; Proteomics International. T. Davis: Speaker's Bureau; Novo Nordisk A\/S. Research Support; Eli Lilly and Company.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-1862-lb","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:23:12Z","timestamp":1749792192000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["1862-LB: Next-Generation PromarkerD vs. Standard of Care for Assessing Kidney Function Decline in Type 2 Diabetes"],"prefix":"10.2337","volume":"74","author":[{"given":"KIRSTEN E.","family":"PETERS","sequence":"first","affiliation":[{"name":"Perth, Australia, Fremantle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SCOTT","family":"BRINGANS","sequence":"additional","affiliation":[{"name":"Perth, Australia, Fremantle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WENDY A.","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Perth, Australia, Fremantle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD J.","family":"LIPSCOMBE","sequence":"additional","affiliation":[{"name":"Perth, Australia, Fremantle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIMOTHY","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Perth, Australia, Fremantle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1862-LB\/158784\/1862-LB-Next-Generation-PromarkerD-vs-Standard-of","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1862-LB\/158784\/1862-LB-Next-Generation-PromarkerD-vs-Standard-of","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T15:53:04Z","timestamp":1750434784000},"score":7.628494,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1862-LB\/158784\/1862-LB-Next-Generation-PromarkerD-vs-Standard-of"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-1862-lb","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"1862-LB"},{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:03:30Z","timestamp":1760043810757},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1111\/imj.12955","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T05:42:50Z","timestamp":1453873370000},"page":"119-120","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acrokeratosis paraneoplastica (Bazex syndrome) associated with metastatic cutaneous squamous cell carcinoma"],"prefix":"10.1111","volume":"46","author":[{"given":"S.","family":"Vatandoust","sequence":"first","affiliation":[{"name":"Flinders Medical Centre Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. P.","family":"McKay","sequence":"additional","affiliation":[{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"McLeay","sequence":"additional","affiliation":[{"name":"Flinders Medical Centre Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Miliauskas","sequence":"additional","affiliation":[{"name":"SA Pathology, The Queen Elizabeth Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Flinders Medical Centre Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Wesley","sequence":"additional","affiliation":[{"name":"Dermatology Private Practice Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kichenadasse","sequence":"additional","affiliation":[{"name":"Flinders Medical Centre Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,27]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60240-2"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02504.x"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.09.022"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01083.x"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.057"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050044"}],"container-title":["Internal Medicine Journal"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.12955","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.12955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T12:14:31Z","timestamp":1696248871000},"score":7.6283584,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.12955"}},"issued":{"date-parts":[[2016,1]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/imj.12955"],"URL":"https:\/\/doi.org\/10.1111\/imj.12955","archive":["Portico"],"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2015-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T05:10:42Z","timestamp":1706159442197},"reference-count":27,"publisher":"Australasian College of Road Safety","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JRS"],"abstract":"Temporary road signage is used throughout road networks to regulate traffic and provide warnings to road users. Wind and other factors induce frequent falling of temporary road signage and are a major road safety concern that needs to be addressed. The main aim of this paper was to gain an understanding of temporary road sign stability in the presence of passing road trains and investigate the possibility of stabilising temporary road signage through appropriate design modifications. Simulations and experimental trials were carried out to assess the stability of current temporary road signs used in the industry. This analysis used Ansys Fluent to simulate fluid dynamics in order to infer road sign stability. A field experimental trial was performed in Western Australia\u2019s Pilbara Region using a modified temporary road sign developed based on the outcome of the Ansys simulation. The findings from the simulations showed that the current design is unstable and highly prone to wind induced failure. The simulations suggest that road train transit at 100 km\/h is capable of inducing approximately 8 m\/s wind velocity in the proximity of the sign, which is greater than that permissible for a rigid sign with no leg mobility. Field trials showed that the modified sign remained stable at 1.2 m from the edge line although it was still prone to falling over at closer distances.<\/jats:p>","DOI":"10.33492\/jrs-d-22-00037","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T02:51:20Z","timestamp":1673578280000},"page":"23-38","update-policy":"http:\/\/dx.doi.org\/10.13003\/0pyd3js","source":"Crossref","is-referenced-by-count":0,"title":["Understanding and improving temporary road sign stability"],"prefix":"10.33492","volume":"34","author":[{"given":"Anandanarayanan Nanda","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, The University Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew Louis","family":"Guzzomi","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, The University Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Amoh-Gyimah","sequence":"additional","affiliation":[{"name":"Main Roads Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ellis","sequence":"additional","affiliation":[{"name":"Main Roads Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendon","family":"Wiseman","sequence":"additional","affiliation":[{"name":"Main Roads Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19008","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Altinisik, A., Kutukceken, E., & Umur, H. (2015). Experimental and Numerical Aerodynamic Analysis of a passenger car: Influence on the Blockage Ratio and drag coefficient. Journal of Fluids Engineering, 137(8), 081104. https:\/\/doi.org\/10.1115\/1.4030183","DOI":"10.1115\/1.4030183"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"ANSYS. (2021). Fluent: Fluid Simulations Software. https:\/\/www.ansys.com\/en-gb\/products\/fluids\/ansys-fluent","DOI":"10.1002\/9781119388937.ch2"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Cali, P. M., & Covert, E. E. (2000). Experimental measurements of the loads induced on an overhead highway sign structure by vehicle-induced gusts. Journal of Wind Engineering and Industrial Aerodynamics, 84(1), 87\u2013100. https:\/\/doi.org\/10.1016\/s0167-6105(99)00045-8","DOI":"10.1016\/s0167-6105(99)00045-8"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Coleman, S. A., & Baker, C. J. (1994). An experimental study of the aerodynamic behaviour of high sided lorries in cross winds. Journal of Wind Engineering and Industrial Aerodynamics, 53(3), 401\u2013429. https:\/\/doi.org\/10.1016\/0167-6105(94)90093-0","DOI":"10.1016\/0167-6105(94)90093-0"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Flay, R. G. J. (2013). Bluff Body Aerodynamics. Advanced Structural Wind Engineering, 59\u201384. https:\/\/doi.org\/10.1007\/978-4-431-54337-4_3","DOI":"10.1007\/978-4-431-54337-4_3"},{"key":"ref5","unstructured":"Geerts, B., & Linacre, E. (1997). The Height of the Tropopause. http:\/\/www-das.uwyo.edu\/~geerts\/cwx\/notes\/chap01\/tropo.html"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Irwin, P. A. (2008). Bluff body aerodynamics in wind engineering. Journal of Wind Engineering and Industrial Aerodynamics, 96(6\u20137), 701\u2013712. https:\/\/doi.org\/10.1016\/j.jweia.2007.06.008","DOI":"10.1016\/j.jweia.2007.06.008"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Kataoka, H., Ono, Y., & Enoki, K. (2020). Applications and prospects of CFD for wind engineering fields. Journal of Wind Engineering and Industrial Aerodynamics, 205(104310), 104310. https:\/\/doi.org\/10.1016\/j.jweia.2020.104310","DOI":"10.1016\/j.jweia.2020.104310"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Kent, C. W., Grimmond, C. S. B., Gatey, D., & Barlow, J. F. (2018). Assessing methods to extrapolate the vertical wind-speed profile from surface observations in a city centre during strong winds. Journal of Wind Engineering and Industrial Aerodynamics, 173, 100\u2013111. https:\/\/doi.org\/10.1016\/j.jweia.2017.09.007","DOI":"10.1016\/j.jweia.2017.09.007"},{"key":"ref9","unstructured":"Kleyweg, M. (2020). Heavy Vehicle Access Strategy. KCTT."},{"key":"ref10","unstructured":"Konow, H. M. (2015). Tall wind profiles in heterogeneous terrain. University of Hamburg."},{"key":"ref11","unstructured":"Larsson, H. (2020). Method Development for CFD Analysis of Heavy Truck Aerodynamics: Investigations of Effects of Partitioning for Parallel Simulations, Bi-stable Flow States for Steady Simulations, and Effects of Split-line Variation on Drag. https:\/\/odr.chalmers.se\/items\/a2f3c04a-4b8c-4bc3-b518-bf0178271e75\/full"},{"key":"ref12","unstructured":"M. Raciti Castelli, P. Cioppa, & E. Benini. (2012). Numerical Simulation Of The Flow Field Around A 30\u00b0 Inclined Flat Plate. World Academy of Science, Engineering and Technology, Open Science Index 63, International Journal of Aerospace and Mechanical Engineering, 6(3), 692\u2013697. https:\/\/doi.org\/10.5281\/ZENODO.1061946"},{"key":"ref13","unstructured":"Main Roads Western Australia. (2019). An Evaluation of the Stability of Temporary Road Signs. Main Roads Western Australia."},{"key":"ref14","unstructured":"Main Roads Western Australia. (2021). Heavy Vehicles Permit Order Scheme. https:\/\/www.mainroads.wa.gov.au\/heavy-vehicles\/permit-order-scheme\/"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Mihora, D., Friedman, K., & Hutchinson, J. (2012). Friction Between Steel and Asphalt Without Gouging Under Representative Rollover Impact Pressures. In Proceedings of the ASME 2012 International Mechanical Engineering Congress and Exposition: Vol. 11: Transportation Systems (pp. 213\u2013217). https:\/\/doi.org\/10.1115\/imece2012-88983","DOI":"10.1115\/imece2012-88983"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Murakami, S. (1993). Comparison of various turbulence models applied to a bluff body. Journal of Wind Engineering and Industrial Aerodynamics, 46\u201347, 21\u201336. https:\/\/doi.org\/10.1016\/0167-6105(93)90112-2","DOI":"10.1016\/0167-6105(93)90112-2"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Murakami, S., & Mochida, A. (1988). 3-D numerical simulation of airflow around a cubic model by means of the model. Journal of Wind Engineering and Industrial Aerodynamics, 31(2\u20133), 283\u2013303. https:\/\/doi.org\/10.1016\/0167-6105(88)90009-8","DOI":"10.1016\/0167-6105(88)90009-8"},{"key":"ref18","unstructured":"National Aeronautics and Space Administration. (2021, May 13). Shape effects on drag. Shape Effects on Drag. https:\/\/www1.grc.nasa.gov\/beginners-guide-to-aeronautics\/shape-effects-on-drag\/"},{"key":"ref19","unstructured":"Palmer, G., Vazquez, B., Knapp, G., & Wright, N. (2003). The practical application of CFD to wind engineering problems. Eighth International IBPSA Conference. http:\/\/www.ibpsa.org\/proceedings\/bs2003\/bs03_0995_1000.pdf"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Quinn, A. D., Baker, C. J., & Wright, N. G. (2001a). Wind and vehicle induced forces on flat plates\u2014Part 1: wind induced force. Journal of Wind Engineering and Industrial Aerodynamics, 89(9), 817\u2013829. https:\/\/doi.org\/10.1016\/s0167-6105(01)00070-8","DOI":"10.1016\/s0167-6105(01)00070-8"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Quinn, A. D., Baker, C. J., & Wright, N. G. (2001b). Wind and vehicle induced forces on flat plates\u2014Part 2: vehicle induced force. Journal of Wind Engineering and Industrial Aerodynamics, 89(9), 831\u2013847. https:\/\/doi.org\/10.1016\/s0167-6105(01)00071-x","DOI":"10.1016\/s0167-6105(01)00071-x"},{"key":"ref22","unstructured":"Regulator, N. H. (2020). Information Sheet \u2013 Road Train Speed Limits \u2013 Including B-triples. National Heavy Vehicle Regulator."},{"key":"ref23","unstructured":"Starr Instruments. (2021). Force Gauge. https:\/\/starrinstruments.co.nz\/force-gauge\/2-fgd-series.html#\/load_capacity-100n"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"The University of Western Australia. (2021). Closed-loop Wind Tunnel. Closed-Loop Wind Tunnel. https:\/\/www.ceme.uwa.edu.au\/__data\/assets\/pdf_file\/0005\/2816627\/Wind-tunnel.pdf","DOI":"10.31390\/gradschool_theses.2469"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Wei, Y. (2017). The development and application of CFD technology in mechanical engineering. IOP Conference Series: Materials Science and Engineering, 274, 012012. https:\/\/doi.org\/10.1088\/1757-899x\/274\/1\/012012","DOI":"10.1088\/1757-899x\/274\/1\/012012"},{"key":"ref26","unstructured":"World Weather Online. (2021). Pilbara Weather Average. https:\/\/www.worldweatheronline.com\/pilbara-weather-averages\/western-australia\/au.aspx"}],"container-title":["Journal of Road Safety"],"language":"en","link":[{"URL":"https:\/\/journalofroadsafety.org\/article\/67858-understanding-and-improving-temporary-road-sign-stability","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T01:02:54Z","timestamp":1706144574000},"score":7.628164,"resource":{"primary":{"URL":"https:\/\/journalofroadsafety.org\/article\/67858-understanding-and-improving-temporary-road-sign-stability"}},"issued":{"date-parts":[[2023,2,8]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,2,8]]}},"URL":"https:\/\/doi.org\/10.33492\/jrs-d-22-00037","ISSN":["2652-4252","2652-4260"],"issn-type":[{"value":"2652-4252","type":"electronic"},{"value":"2652-4260","type":"print"}],"published":{"date-parts":[[2023,2,8]]},"assertion":[{"value":"2022-7-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-1-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-2-8","order":2,"name":"published_online","label":"Published Online","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:02:48Z","timestamp":1777392168422,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["AlterNative: An International Journal of Indigenous Peoples"],"published-print":{"date-parts":[[2024,12]]},"abstract":"Aboriginal and Torres Strait Islander peoples face significant challenges in accessing mainstream health services due to the ongoing impacts of racism, colonisation, and intergenerational trauma. To address health inequalities, it is important to build Aboriginal and Torres Strait Islander workforce capacity in the health professions where there is significant under-representation. A pilot mentoring programme was developed to support Aboriginal and Torres Strait Islander ear and hearing health professionals and students, which aimed to understand their expectations and experiences. Six participants enrolled in the study, two mentors and four mentees, all from a speech pathology background. The study found that maintaining relationships with other Aboriginal speech pathologists was vital for longevity in the profession. The study stresses the importance of workplaces and universities ensuring that individuals are not thrown into culturally unsafe situations and that they are culturally safe and responsive.<\/jats:p>","DOI":"10.1177\/11771801241291196","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T23:31:27Z","timestamp":1731367887000},"page":"711-720","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["\u201cI have a sis in the profession for life, that\u2019s who my mentor is\u201d: evaluating a pilot mentoring programme for Aboriginal and Torres Strait Islander speech pathology students and professionals"],"prefix":"10.1177","volume":"20","author":[{"given":"Alice","family":"Sheehan (Yuin)","sequence":"first","affiliation":[{"name":"Monash Health, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrine","family":"Butler (Kuku Yalanji Wulgurukaba)","sequence":"additional","affiliation":[{"name":"Queensland Health, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Lewis (Iman)","sequence":"additional","affiliation":[{"name":"Australian Catholic University, Australia"},{"name":"Speech Pathology Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Baker","sequence":"additional","affiliation":[{"name":"Monash Health, Australia"},{"name":"La Trobe University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abby","family":"Foster","sequence":"additional","affiliation":[{"name":"Monash Health, Australia"},{"name":"La Trobe University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Davenport","sequence":"additional","affiliation":[{"name":"La Trobe University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"O\u2019Rourke","sequence":"additional","affiliation":[{"name":"Monash Health, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A","family":"Smith","sequence":"additional","affiliation":[{"name":"Flinders University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6681-0466","authenticated-orcid":false,"given":"Andrea","family":"Simpson","sequence":"additional","affiliation":[{"name":"Monash Health, Australia"},{"name":"La Trobe University, Australia"},{"name":"Charles Darwin University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"bibr1-11771801241291196","doi-asserted-by":"publisher","DOI":"10.1177\/11771801211015442"},{"key":"bibr2-11771801241291196","doi-asserted-by":"publisher","DOI":"10.5204\/ijcis.v3i1.57"},{"key":"bibr3-11771801241291196","doi-asserted-by":"publisher","DOI":"10.3912\/OJIN.Vol24No01PPT20"},{"key":"bibr4-11771801241291196","doi-asserted-by":"publisher","DOI":"10.1080\/0306988031000086189"},{"key":"bibr5-11771801241291196","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzr008"},{"key":"bibr6-11771801241291196","doi-asserted-by":"publisher","DOI":"10.1177\/11771801231168140"},{"key":"bibr7-11771801241291196","volume":"214","author":"Finlay S. M.","year":"2021","journal-title":"Medical Journal of Australia"},{"key":"bibr8-11771801241291196","unstructured":"Fogarty W., Bulloch H., McDonnell S., Davis M. (2018). Deficit discourse and Indigenous health: How narrative framings of Aboriginal and Torres Strait Islander people are reproduced in policy. Lowitja Institute. https:\/\/www.lowitja.org.au\/content\/Document\/Lowitja-Publishing\/deficit-discourse.pdf"},{"key":"bibr9-11771801241291196","doi-asserted-by":"publisher","DOI":"10.18793\/LCJ2015.17.01"},{"key":"bibr10-11771801241291196","doi-asserted-by":"publisher","DOI":"10.1080\/0312407X.2014.928335"},{"key":"bibr11-11771801241291196","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2004.tb06056.x"},{"key":"bibr12-11771801241291196","unstructured":"Indigenous Allied Health Australia. (n.d.). About IAHA. https:\/\/iaha.com.au\/about-us\/"},{"key":"bibr13-11771801241291196","unstructured":"Kenny C. (2004). A holistic framework for Aboriginal policy research. https:\/\/publications.gc.ca\/collections\/Collection\/SW21-114-2004E.pdf"},{"key":"bibr14-11771801241291196","doi-asserted-by":"publisher","DOI":"10.1177\/1363461512444673"},{"key":"bibr15-11771801241291196","volume":"19","author":"Lewis T.","year":"2017","journal-title":"Journal of Clinical Practice in Speech-Language Pathology"},{"key":"bibr16-11771801241291196","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-22174-3_8"},{"key":"bibr17-11771801241291196","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12201"},{"key":"bibr18-11771801241291196","author":"Simpson A.","year":"2022","journal-title":"Indigenous students\u2019 journeys to and through allied healthcare programs"},{"key":"bibr19-11771801241291196","doi-asserted-by":"publisher","DOI":"10.18584\/iipj.2014.5.1.5"},{"key":"bibr20-11771801241291196","doi-asserted-by":"publisher","DOI":"10.1111\/1753-6405.12864"}],"container-title":["AlterNative: An International Journal of Indigenous Peoples"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11771801241291196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/11771801241291196","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/11771801241291196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:56:17Z","timestamp":1777370177000},"score":7.627999,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/11771801241291196"}},"issued":{"date-parts":[[2024,11,11]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1177\/11771801241291196"],"URL":"https:\/\/doi.org\/10.1177\/11771801241291196","ISSN":["1177-1801","1174-1740"],"issn-type":[{"value":"1177-1801","type":"print"},{"value":"1174-1740","type":"electronic"}],"published":{"date-parts":[[2024,11,11]]}},{"indexed":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T18:41:12Z","timestamp":1656355272900},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"19_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2014,10,1]]},"abstract":"Abstract<\/jats:title>\n Colorectal cancer (CRC) is the second most common internal cancer in Australia and the second leading cause of cancer death with &gt; 4,400 deaths in 2007 [1]. Currently there are greater than 14,000 newly diagnosed cases annually in Australia with direct costs of over $2 billion per annum [1]. Worldwide, there is an annual incidence of almost a million CRC cases with an annual mortality around 600,000 [2]. Unfortunately, 30-50% of patients have occult or overt metastases at presentation and once tumours have metastasised prognosis is very poor with a five year survival of less than 10% [3]. By contrast, greater than 90% of patients who present while the tumour is still localised (Dukes' stage A) will still be alive after 5 years and can be considered cured. The early detection of CRC and clinically significant pre-cancerous lesions (adenomas) would therefore significantly reduce the health burden of this disease [3]. Currently the only widely used non-invasive screening test for CRC is the faecal occult blood test (FOBT). Even though screening with FOBT has been shown to lead to reductions in CRC incidence and mortality, there are significant issues that limit its effectiveness as a diagnostic screening tool, such as a poor positive predictive value of 5.3% for suspected cancer and low participation rate of approximately 35% as seen in the Australian National Bowel Cancer Screening Program. To overcome some of the limitations of the FOBT, we believe that a blood test may increase participation rates and could provide a useful adjunct to FOBT<\/jats:p>\n In our recent studies we screened over 65 candidate CRC biomarkers using both commercially sourced ELISA kits and reagents developed in-house, in more than 550 CRC patients and controls that were collected with strict SOP based on the EDRN and HuPO. Using logistic regression, we have defined a panel of 3 blood-borne protein biomarkers that differentiates between CRC and normal patient sera with 95% specificity and 75% sensitivity in a single measurement (c.f. FOBT: sensitivity 65.8%, specificity 95% [4]). Currently we are prospectively collecting a new cohort of over 1,000 blood samples from volunteers that have undergone colonoscopy, that include CRC patients , controls and other pathologies (IBD, other cancers etc) to specifically determine the performance of this blood test in asymptomatic and surveillance screening populations.<\/jats:p>\n 1. Australian Institute for Health and Welfare and Australasian Association of Cancer Registries 2010. Cancer in Australia: an overview, 2010. Cancer series no. 60. Cat. No. CAN 56. Canberra: AIHW.<\/jats:p>\n 2. Weitz, J., et al., Colorectal cancer. Lancet, 2005. 365(9454): p. 153-65<\/jats:p>\n 3. Etzioni, R., et al., The case for early detection. Nat Rev Cancer, 2003. 3(4): p. 243-52.<\/jats:p>\n 4. Morikawa, T., et al., A comparison of the immunochemical fecal occult blood test and total colonoscopy in the asymptomatic population. Gastroenterology, 2005. 129(2): p. 422-8.<\/jats:p>\n Note: This abstract was not presented at the meeting.<\/jats:p>\n Citation Format: Leah J. Cosgrove, Kim Fung, Ilka Priebe, Leanne Purins, Bruce Tabor, Mike Buckley, Celine Pompeia, Gemma Brierley, Edouard Nice, Tim Adams, Peter Gibbs, Jeanne Tie, Andrew Ruszkiewicz, James Moore, Trevor Lockett, Tony Burgess. Doctor. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4099. doi:10.1158\/1538-7445.AM2014-4099<\/jats:p>","DOI":"10.1158\/1538-7445.am2014-4099","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T19:03:43Z","timestamp":1430766223000},"page":"4099-4099","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 4099: Doctor"],"prefix":"10.1158","volume":"74","author":[{"given":"Leah J.","family":"Cosgrove","sequence":"first","affiliation":[{"name":"1CSIRO, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Fung","sequence":"additional","affiliation":[{"name":"1CSIRO, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilka","family":"Priebe","sequence":"additional","affiliation":[{"name":"1CSIRO, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanne","family":"Purins","sequence":"additional","affiliation":[{"name":"1CSIRO, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Tabor","sequence":"additional","affiliation":[{"name":"2CSIRO, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Buckley","sequence":"additional","affiliation":[{"name":"2CSIRO, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine","family":"Pompeia","sequence":"additional","affiliation":[{"name":"1CSIRO, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Brierley","sequence":"additional","affiliation":[{"name":"1CSIRO, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Nice","sequence":"additional","affiliation":[{"name":"3Monash University, Melbourne, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Adams","sequence":"additional","affiliation":[{"name":"4CSIRO, Melbourne, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Gibbs","sequence":"additional","affiliation":[{"name":"5WEHI, Melbourne, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Tie","sequence":"additional","affiliation":[{"name":"5WEHI, Melbourne, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Ruszkiewicz","sequence":"additional","affiliation":[{"name":"6SA Pathology, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Moore","sequence":"additional","affiliation":[{"name":"6SA Pathology, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Lockett","sequence":"additional","affiliation":[{"name":"2CSIRO, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Burgess","sequence":"additional","affiliation":[{"name":"5WEHI, Melbourne, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/74\/19_Supplement\/4099\/596190\/Abstract-4099-Doctor","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/74\/19_Supplement\/4099\/596190\/Abstract-4099-Doctor","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T18:06:12Z","timestamp":1656353172000},"score":7.6279206,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/74\/19_Supplement\/4099\/596190\/Abstract-4099-Doctor"}},"issued":{"date-parts":[[2014,10,1]]},"references-count":0,"journal-issue":{"issue":"19_Supplement","published-print":{"date-parts":[[2014,10,1]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2014-4099","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2014,10,1]]}},{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:38:12Z","timestamp":1788518292077,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2024,4]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>Epilepsy surgery is known to be underutilized. Machine learning\u2010natural language processing (ML\u2010NLP) may be able to assist with identifying patients suitable for referral for epilepsy surgery evaluation.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data were collected from two tertiary hospitals for patients seen in neurology outpatients for whom the diagnosis of \u201cepilepsy\u201d was mentioned. Individual case note review was undertaken to characterize the nature of the diagnoses discussed in these notes, and whether those with epilepsy fulfilled prespecified criteria for epilepsy surgery workup (namely focal drug refractory epilepsy without contraindications). ML\u2010NLP algorithms were then developed using fivefold cross\u2010validation on the first free\u2010text clinic note for each patient to identify these criteria.<\/jats:p><\/jats:sec>Results<\/jats:title>There were 457 notes included in the study, of which 250 patients had epilepsy. There were 37 (14.8%) individuals who fulfilled the prespecified criteria for epilepsy surgery referral without described contraindications, 32 (12.8%) of whom were not referred for epilepsy surgical evaluation in the given clinic visit. In the prediction of suitability for epilepsy surgery workup using the prespecified criteria, the tested models performed similarly. For example, the random forest model returned an area under the receiver operator characteristic curve of 0.97 (95% confidence interval 0.93\u20131.0) for this task, sensitivity of 1.0, and specificity of 0.93.<\/jats:p><\/jats:sec>Significance<\/jats:title>This study has shown that there are patients in tertiary hospitals in South Australia who fulfill prespecified criteria for epilepsy surgery evaluation who may not have been referred for such evaluation. ML\u2010NLP may assist with the identification of patients suitable for such referral.<\/jats:p><\/jats:sec>Plain Language Summary<\/jats:title>Epilepsy surgery is a beneficial treatment for selected individuals with drug\u2010resistant epilepsy. However, it is vastly underutilized. One reason for this underutilization is a lack of prompt referral of possible epilepsy surgery candidates to comprehensive epilepsy centers. Natural language processing, coupled with machine learning, may be able to identify possible epilepsy surgery candidates through the analysis of unstructured clinic notes. This study, conducted in two tertiary hospitals in South Australia, demonstrated that there are individuals who fulfill criteria for epilepsy surgery evaluation referral but have not yet been referred. Machine learning\u2010natural language processing demonstrates promising results in assisting with the identification of such suitable candidates in Australia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.12901","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T12:04:32Z","timestamp":1706011472000},"page":"635-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Identifying epilepsy surgery referral candidates with natural language processing in an Australian context"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8310-0853","authenticated-orcid":false,"given":"Sheryn","family":"Tan","sequence":"first","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudy","family":"Goh","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeng Swen","family":"Ng","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charis","family":"Tang","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleo","family":"Ng","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Kovoor","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Stretton","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aashray","family":"Gupta","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Gold Coast University Hospital Southport Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Ovenden","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merran R.","family":"Courtney","sequence":"additional","affiliation":[{"name":"Monash University Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9251-5471","authenticated-orcid":false,"given":"Andrew","family":"Neal","sequence":"additional","affiliation":[{"name":"Monash University Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Whitham","sequence":"additional","affiliation":[{"name":"Flinders University and Medical Centre Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Frasca","sequence":"additional","affiliation":[{"name":"Flinders University and Medical Centre Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Kiley","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Abou\u2010Hamden","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Bacchi","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Flinders University and Medical Centre Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"Deloitte.The economic burden of epilepsy in Australia 2019\u20132020. Accessed on April 8 2023. Available from:https:\/\/www2.deloitte.com\/content\/dam\/Deloitte\/au\/Documents\/Economics\/deloitte\u2010au\u2010dae\u2010economic\u2010burden\u2010of\u2010epilepsy\u2010260220.pdf"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02397.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03398.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2023.06.010"},{"key":"e_1_2_13_6_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/978-81-322-3972-7_19","volume-title":"Natural language processing. 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History"}}]},{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:07:29Z","timestamp":1767168449590,"version":"build-2238731810"},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"13_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,7,1]]},"abstract":"Abstract<\/jats:title>\n Treatment of breast cancer represents a major therapeutic challenge, and thus identification of new targeted therapy is of paramount importance. Anti-apoptotic proteins, BCL2 and MCL1, and oncoprotein c-MYC are implicated in evasion of apoptosis and resistance to chemotherapy in both triple-negative breast cancer (TNBC) and estrogen receptor-positive breast cancer (ER+ BC). Transcription of these oncogenic factors requires cyclin dependent kinase 9 (CDK9). CDK9 phosphorylates the C-terminal domain (CTD) of RNA polymerase II (RNAPII) and acts as a rate-limiting step of transcription. Thus, targeting CDK9 can reduce the expression of these proteins effectively and simultaneously, presenting a promising therapeutic strategy for breast cancer. Utilizing extensive medicinal chemistry and biochemical assays, we previously identified and developed LS007 as an orally bioavailable (F = 56% in cynomolgus monkey at 4 mg\/kg), and nanomolar inhibitor of CDK9 (Ki = 4 nM). In vitro, inhibition of CDK9-mediated phosphorylation of RNAPII (pRNAPIIS2) by LS007 resulted in downregulation of BCL2, MCL1 and c-MYC and activation of PARP cleavage indicating apoptosis in breast cancer cells (TNBC: MDA-MB-231, Hs578T and ER+ BC: MCF-7, T47D). In vivo, LS007 was well tolerated in mice after oral administration (MTD = 50 mg\/kg QD and 100 mg\/kg Q3D). In MDA-MB-231 TNBC xenograft, by daily oral dosing at 25 mg\/kg and 50 mg\/kg LS007 significantly reduced tumor growth (p &lt; 0.001) with T\/C of 53 % and 35 %, respectively, on day 21, when compared to the vehicle dosed group. Similarly, in MCF-7 ER+ BC xenograft model, oral dosing of LS007 at 25 mg\/kg QD, 50 mg\/kg Q2D and 75 mg\/kg Q3D showed significant tumor growth inhibition with T\/C of 50 %, 60 % and 47 %, respectively, and increased in animal survival (p &lt; 0.001) compared to vehicle control. It was safe in the xenograft models as there was no significant body weight loss or other overt toxicities. In addition, histological analysis of major organs (liver, kidney, heart, bone marrow and intestine) of the mice receiving LS007 showed no drug related toxicities. These results support for development of LS007 towards the clinical trials for the treatment of TNBC and ER+ BC.<\/jats:p>\n Citation Format: Muhammed Hamidur Rahaman, Yinghui Zhang, Md Saiful Islam, Gary Heinemann, Abel Tesfaye Anshabo, Hugo Albrecht, Robert Milne, Shudong Wang. LS007, a potent and orally bioavailable CDK9 inhibitor, suppresses the growth of triple-negative and estrogen receptor-positive breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4427.<\/jats:p>","DOI":"10.1158\/1538-7445.am2019-4427","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T18:19:00Z","timestamp":1565201940000},"page":"4427-4427","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 4427: LS007, a potent and orally bioavailable CDK9 inhibitor, suppresses the growth of triple-negative and estrogen receptor-positive breast cancer"],"prefix":"10.1158","volume":"79","author":[{"given":"Muhammed Hamidur","family":"Rahaman","sequence":"first","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Saiful","family":"Islam","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Heinemann","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abel Tesfaye","family":"Anshabo","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Albrecht","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Milne","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shudong","family":"Wang","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/79\/13_Supplement\/4427\/636285\/Abstract-4427-LS007-a-potent-and-orally","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/79\/13_Supplement\/4427\/636285\/Abstract-4427-LS007-a-potent-and-orally","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T20:51:23Z","timestamp":1655844683000},"score":7.6274447,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/79\/13_Supplement\/4427\/636285\/Abstract-4427-LS007-a-potent-and-orally"}},"issued":{"date-parts":[[2019,7,1]]},"references-count":0,"aliases":["10.1158\/1538-7445.sabcs18-4427"],"journal-issue":{"issue":"13_Supplement","published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2019-4427","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2019,7,1]]}},{"indexed":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T04:43:55Z","timestamp":1656132235571},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"13_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Abstract<\/jats:title>\n Cyclin-dependent kinases 4 and 6 (CDK4\/6) in concert with D-type cyclins, are vital drivers of the cell cycle. Activated CDK4\/6-cyclin D complexes regulate cell proliferation, senescence and apoptosis via phosphorylation of proteins including Rb, FOXM1 and SMAD3. Deregulation of the CDK4\/6-cyclin D-Rb-E2F pathway has been found in over 90% of human cancers, and amplification of genes coding for cyclin D1 (CCND1) and CDK4\/6, or deletions of the locus encoding p16INK4a are the major mechanisms. For instance, CCDN1 amplification and cyclin D protein overexpression are seen in ~ 35% and \u2265 50% of breast cancer cases, respectively. Similarly, \u2265 40% of prostate cancers overexpress CDK6 while loss of p16INK4a occurs in ~ 80% of head and neck squamous cell carcinoma. Specific mutations or translocations in the genes encoding CDK4\/6-cyclin D-Rb-E2F pathway are aberrantly activated in melanoma and mantle cell lymphoma. Therefore, CDK4\/6 inhibition can be an effective treatment strategy for these cancers.<\/jats:p>\n With our extensive medicinal chemistry, biochemical and cellular assays, in vivo pharmacokinetic, safety and efficacy studies, we have identified a highly potent dual inhibitor of CDK4\/6, 3-14, that showed excellent selectivity over a panel of &gt;360 kinases. 3-14 is more potent anti-proliferative agent than palbociclib against a range of cancer cell lines including breast, ovarian, colon, prostate, pancreatic, lung and melanoma cancer cells. 3-14 arrested cells in G1 phase of the cell cycle, prevented colony formation and induced senescence in MCF7 breast cancer cells. 3-14 caused dose dependent inhibition of Rb phosphorylation at S780, S795 and S807\/11 residues, and this was translated to the reduction in the levels of E2F regulated proteins such as cyclin E2, A2. Moreover, 3-14 possessed excellent pharmaceutical properties, and pharmacokinetics with high oral bioavailability in rodents. 3-14 (MTD = 250 mg\/kg) is better tolerated than palbociclib (MTD = 150 mg\/kg) in mice. In A2780 ovarian cancer xenograft, 3-14 (100 mg\/kg p.o. daily) delayed tumor growth (i.e. T\/C = 24.4 %) and increased animal life span (90%), and was more efficacious<\/jats:p>\n compared to palbociclib (i.e. T\/C = 38% and ILS = 73%). Both 3-14 and palbociclib didn't cause histopathological changes in the bone marrow, intestine, liver, heart and kidney except for the non-significant reduction in the neutrophils. Given its excellent efficacy and safety as well as pharmacokinetic profiles, 3-14 is warranted as a development candidate for further preclinical and clinical studies.<\/jats:p>\n Citation Format: Laychiluh Bantie, Solomon Tadesse, Jimma Likisa, Mingfeng Yu, Benjamin Noll, Hugo Albrecht, Robert Milne, Shudong Wang. Preclinical development of a highly potent and selective dual inhibitor of CDK4\/6 for the treatment of cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. 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Consensus statements based on current evidence will help the development of treatment guidelines.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To develop evidence\u2010based consensus statements for\n TDM<\/jats:styled-content>\n \u2010guided anti\u2010\n TNF<\/jats:styled-content>\n therapy in\n IBD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A committee of 25 Australian and international experts was assembled. The initial draft statements were produced following a systematic literature search. A modified Delphi technique was used with 3 iterations. Statements were modified according to anonymous voting and feedback at each iteration. Statements with 80% agreement without or with minor reservation were accepted.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n 22\/24 statements met criteria for consensus. For anti\u2010\n TNF<\/jats:styled-content>\n agents,\n TDM<\/jats:styled-content>\n should be performed upon treatment failure, following successful induction, when contemplating a drug holiday and periodically in clinical remission only when results would change management. To achieve clinical remission in luminal\n IBD<\/jats:styled-content>\n , infliximab and adalimumab trough concentrations in the range of 3\u20108 and 5\u201012\u00a0\u03bcg\/mL, respectively, were deemed appropriate. The range may differ for different disease phenotypes or treatment endpoints\u2014such as fistulising disease or to achieve mucosal healing. In treatment failure,\n TDM<\/jats:styled-content>\n may identify mechanisms to guide subsequent decision\u2010making. In stable clinical response,\n TDM<\/jats:styled-content>\n \u2010guided dosing may avoid future relapse. Data indicate drug\u2010tolerant anti\u2010drug antibody assays do not offer an advantage over drug\u2010sensitive assays. Further data are required prior to recommending\n TDM<\/jats:styled-content>\n for non\u2010anti\u2010\n TNF<\/jats:styled-content>\n biological agents.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Consensus statements support the role of\n TDM<\/jats:styled-content>\n in optimising anti\u2010\n TNF<\/jats:styled-content>\n agents to treat\n IBD<\/jats:styled-content>\n , especially in\u00a0situations of treatment failure.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.14368","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T03:54:21Z","timestamp":1507866861000},"page":"1037-1053","source":"Crossref","is-referenced-by-count":259,"title":["Review article: consensus statements on therapeutic drug monitoring of anti\u2010tumour necrosis factor therapy in inflammatory bowel diseases"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7771-5248","authenticated-orcid":false,"given":"N.","family":"Mitrev","sequence":"first","affiliation":[{"name":"Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Vande Casteele","sequence":"additional","affiliation":[{"name":"San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1551-9054","authenticated-orcid":false,"given":"C. 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While several lived experience\u2010led services, such as peer respites, are available, their evaluations rarely incorporate outcome measures to assess impact, thereby limiting evidence of their validity as alternatives to clinical services. The aim of this review was to identify and describe the outcome and experience measures used in lived experience\u2010led services to better understand how evidence of their viability and acceptability is captured, and how this evidence supports these services as alternatives to traditional services.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A scoping review of peer\u2010reviewed literature on lived experience\u2010led services was conducted by searching four databases (PsycINFO, Ovid Medline, CINAHL and Embase). Eligibility criteria included studies describing services led and delivered by people with lived experience (LE) of mental health challenges that implemented outcome or experience measures, and that focused on services outside clinical settings and not co\u2010delivered by traditional mental health professionals.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Thirteen studies were included that used a range of measures, including existing or adapted clinical and recovery survey outcomes. Results identify diversity in the outcomes measured and a lack of measures developed by the lived experience workforce.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n While the results highlight positive outcomes of lived experience run services, they also reveal a reliance on traditional outcome measures and a critical need to develop LE\u2010led outcome measures that align with lived\u2010experience values and practice.<\/jats:p>\n <\/jats:sec>\n \n Lived Experience or Public Contribution<\/jats:title>\n This manuscript was conceptualised and led by two researchers in designated lived experience research roles. These researchers identify as having lived\/living experience of mental health challenges, service use and histories of trauma. The partnership between these two lived experience researchers (first and second authors) occurred through their shared interest in lived experience\u2010led services and service evaluation. These authors use their lived experience to inform and guide this research, including the study's design, analysis and interpretation. The fourth author is also in a designated lived experience researcher role and contributed to the writing and revisions of the paper.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hex.70849","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:43:13Z","timestamp":1788777793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Scoping Review of Outcome Measures Used in Lived Experience\u2010Led Mental Health Services"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4569-1226","authenticated-orcid":false,"given":"Helena","family":"Roennfeldt","sequence":"first","affiliation":[{"name":"Mind Australia Burnley Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3777-6713","authenticated-orcid":false,"given":"Heather","family":"Craig","sequence":"additional","affiliation":[{"name":"Mind Australia Burnley Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Botchway","sequence":"additional","affiliation":[{"name":"Mind Australia Burnley Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Schweizer","sequence":"additional","affiliation":[{"name":"One Door Mental Health Parramatta Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3678-7036","authenticated-orcid":false,"given":"Christina","family":"Ng","sequence":"additional","affiliation":[{"name":"Mind Australia Burnley Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2109-6091","authenticated-orcid":false,"given":"Laura","family":"Hayes","sequence":"additional","affiliation":[{"name":"Mind Australia Burnley Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"On Our Own: Patient\u2010Controlled Alternatives to the Mental Health System","author":"Chamberlin J.","year":"1978"},{"issue":"3","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1176\/ps.37.3.213","article-title":"Self\u2010Help: The Wave of the Future","volume":"37","author":"Zinman S.","year":"1986","journal-title":"Psychiatric Services"},{"issue":"18","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"9650","DOI":"10.3390\/ijerph18189650","article-title":"Subjective Experiences of Mental Health Crisis Care in Emergency Departments: A Narrative Review of the Qualitative Literature","volume":"18","author":"Roennfeldt H.","year":"2021","journal-title":"International Journal of Environmental Research and Public Health"},{"issue":"6","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1192\/bjp.2019.22","article-title":"Experiences of In\u2010Patient Mental Health Services: Systematic Review","volume":"214","author":"Staniszewska S.","year":"2019","journal-title":"British Journal of Psychiatry"},{"issue":"3","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","DOI":"10.1111\/hex.14122","article-title":"Our Wished\u2010For Responses: Recommendations for Creating a Lived and Embodied Sense of Safety During Mental Health Crisis","volume":"27","author":"Roennfeldt H.","year":"2024","journal-title":"Health Expectations"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.20230599"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.201400422"},{"key":"e_1_2_11_9_1","unstructured":"F.GreyandM.O'Hagan(2016).The Effectiveness of Services Led or Run by Consumers in Mental Health: Rapid Review of Evidence for Recovery\u2010Oriented Outcomes: An Evidence Check Rapid Review Brokered by the Sax Institute(www.saxinstitute.org.au) for the Mental Health Commission of New South Wales."},{"issue":"2","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s11126-022-09971-w","article-title":"An Update of Peer Support\/Peer Provided Services Underlying Processes, Benefits, and Critical Ingredients","volume":"93","author":"Fortuna K. 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It is important to determine risk factors that restrain newly diagnosed patients from attending the health care services.<\/jats:p>\n Methods: Our incident cohort included all 1832 patients who were diagnosed with T1D younger than 16 years of age between 1990 and 2009 at the Children's Hospital at Westmead, Sydney, NSW. Median age at diagnosis was 8.8 years [5.5-11.6] and 51% were female. Data was analysed from all their documented visits at our clinic between 1st January 1990 and 22nd February 2017 including personal data, clinical variables, blood tests. DCAS attenders (67%) were compared to non-DCAS attenders (34%) for: BMI, HbA1c and socioeconomic disadvantage (SES) which was based on postal codes of Australian Bureau of Statistics.<\/jats:p>\n Results: Comparing non-DCAS attenders with DCAS attenders, diabetes clinic attendance in the first 2 years was 1.7 vs. 2.5 times per year (p&lt;0.001), with a significant difference in their median HbA1c (7.9 vs. 8.0%, p=0.03) over this time, but no difference in BMI at 2-years. The difference in median lifetime HbA1c was even more significant (8.1 vs. 8.3%, p=&lt;0.001). DCAS attenders continued in the Diabetes Service for a mean of 9.1 years whereas the non-DCAS attenders were followed for 3.8 years (p&lt;0.001). 40% of the non-DCAS group were socio-economical disadvantaged compared to only 23% of the DCAS group (p&lt;0.001). In multivariable analysis, DCAS attendance was associated with more visits in clinics over the first 2 years, less SES and higher median lifetime HbA1c.<\/jats:p>\n Conclusions: SES and less frequent clinic attendance in the first 2 years after diagnosis but not obesity, were predictors of non-uptake of complication screening and are likely to influence the outcome of T1D for these patients. It remains unclear if the non-attenders had medical follow-up at other services.<\/jats:p>\n \n Disclosure<\/jats:title>\n J. Aulich: None. A.K. Chan: None. J. Cusumano: None. A. Pryke: None. P.Z. Benitez-Aguirre: None. M.E. Craig: None. K.C. Donaghue: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-186-lb","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T01:46:35Z","timestamp":1559699195000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["186-LB: Predictors of Diabetes Complication Screening at Two Years from Diagnosis in an Incident Cohort"],"prefix":"10.2337","volume":"68","author":[{"given":"JULIANE","family":"AULICH","sequence":"first","affiliation":[{"name":"Berlin, Germany, Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALBERT K.","family":"CHAN","sequence":"additional","affiliation":[{"name":"Berlin, Germany, Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JANINE","family":"CUSUMANO","sequence":"additional","affiliation":[{"name":"Berlin, Germany, Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALISON","family":"PRYKE","sequence":"additional","affiliation":[{"name":"Berlin, Germany, Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL Z.","family":"BENITEZ-AGUIRRE","sequence":"additional","affiliation":[{"name":"Berlin, Germany, Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA E.","family":"CRAIG","sequence":"additional","affiliation":[{"name":"Berlin, Germany, Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KIM C.","family":"DONAGHUE","sequence":"additional","affiliation":[{"name":"Berlin, Germany, Sydney, Australia, Westmead, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/186-LB\/59838\/186-LB-Predictors-of-Diabetes-Complication","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/186-LB\/59838\/186-LB-Predictors-of-Diabetes-Complication","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:15:55Z","timestamp":1647166555000},"score":7.6268363,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/186-LB\/59838\/186-LB-Predictors-of-Diabetes-Complication"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-186-lb","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"186-LB"},{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:09:24Z","timestamp":1785326964615,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2024,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Anticoagulation can prevent most strokes in individuals with atrial fibrillation (AF); however, many people presenting with stroke and known AF are not anticoagulated. Language barriers and poor health literacy have previously been associated with decreased patient medication adherence. The association between language barriers and initiation of anticoagulation therapy for AF is uncertain.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n The aims of this study were to determine whether demographic factors, including non\u2010English primary language, were (1) associated with not being initiated on anticoagulation for known AF prior to admission with stroke, and (2) associated with non\u2010adherence to anticoagulation in the setting of known AF prior to admission with stroke.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A multicentre retrospective cohort study was conducted for consecutive individuals admitted to the three South Australian tertiary hospitals with stroke units over a 5\u2010year period.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were 6829 individuals admitted with stroke. These cases included 5835 ischaemic stroke patients, 1333 of whom had pre\u2010existing AF. Only 40.0% presenting with ischaemic stroke in the setting of known pre\u2010existing AF were anticoagulated. When controlling for demographics, socioeconomic status and past medical history (including the components of the CHADS2VASC score and anticoagulation contraindications), having a primary language other than English was associated with a lower likelihood of having been commenced on anticoagulant for known pre\u2010stroke AF (odds ratio: 0.52, 95% confidence interval: 0.36\u20130.77,\n P<\/jats:italic>\n =\u20090.001), but was not associated with a differing likelihood of anticoagulation adherence.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n A significant proportion of patients with stroke have pre\u2010existing unanticoagulated AF; these rates are substantially higher if the primary language is other than English. Targeted research and interventions to minimise evidence\u2010treatment gaps in this cohort may significantly reduce stroke burden.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/imj.16253","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T06:12:08Z","timestamp":1697782328000},"page":"620-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pre\u2010stroke anticoagulation for atrial fibrillation in primary English speakers and non\u2010primary English speakers: a multicentre retrospective cohort study"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5130-8628","authenticated-orcid":false,"given":"Stephen","family":"Bacchi","sequence":"first","affiliation":[{"name":"College of Medicine and Public Health, Flinders University Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua G.","family":"Kovoor","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudy","family":"Goh","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aashray K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Gold Coast University Hospital Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8310-0853","authenticated-orcid":false,"given":"Sheryn","family":"Tan","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Ovenden","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh\u2010Son","family":"To","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health, Flinders University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Moey","sequence":"additional","affiliation":[{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanthan","family":"Sanders","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek P.","family":"Chew","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health, Flinders University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Schultz","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health, Flinders University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramesh","family":"Kovoor","sequence":"additional","affiliation":[{"name":"Westmead Private Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4430-3276","authenticated-orcid":false,"given":"Timothy","family":"Kleinig","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Jannes","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.516344"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50496"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-11259-w"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.15420\/ecr.2017:2:2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp058316"},{"key":"e_1_2_6_7_1","unstructured":"Australian Bureau of Statistics.Census of Population and Housing: Socio\u2010Economic Indexes for Areas (SEIFA) Australia 2016 2016.Commonwealth Goverment of 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Medicine Journal"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.16253","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.16253","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.16253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:48:13Z","timestamp":1785325693000},"score":7.6267242,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.16253"}},"issued":{"date-parts":[[2023,10,20]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/imj.16253"],"URL":"https:\/\/doi.org\/10.1111\/imj.16253","archive":["Portico"],"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"published":{"date-parts":[[2023,10,20]]},"assertion":[{"value":"2023-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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residential aged care"],"prefix":"10.1136","author":[{"given":"Anna","family":"Lane","sequence":"first","affiliation":[{"name":"National Ageing Research Institute, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Goh","sequence":"additional","affiliation":[{"name":"National Ageing Research Institute, Australia"},{"name":"The University of Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Gaffy","sequence":"additional","affiliation":[{"name":"National Ageing Research Institute, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayla","family":"Lock","sequence":"additional","affiliation":[{"name":"National Ageing Research Institute, Australia"},{"name":"The University of Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Moore","sequence":"additional","affiliation":[{"name":"APNA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry","family":"Hwang","sequence":"additional","affiliation":[{"name":"Monash University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Hayes","sequence":"additional","affiliation":[{"name":"Northern Health, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Le","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Yates","sequence":"additional","affiliation":[{"name":"Austin Health, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Bloomer","sequence":"additional","affiliation":[{"name":"Griffith University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Len","family":"Gray","sequence":"additional","affiliation":[{"name":"The University of Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimity","family":"Pond","sequence":"additional","affiliation":[{"name":"The University of Tasmania, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Gerber","sequence":"additional","affiliation":[{"name":"RMIT, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Engel","sequence":"additional","affiliation":[{"name":"Monash University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Tacey","sequence":"additional","affiliation":[{"name":"Austin Health, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny","family":"Hills","sequence":"additional","affiliation":[{"name":"Federation University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances","family":"Batchelor","sequence":"additional","affiliation":[{"name":"National Ageing Research Institute, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Bicknell","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra","family":"Nestel","sequence":"additional","affiliation":[{"name":"Monash University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Johnson","sequence":"additional","affiliation":[{"name":"Monash University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Savvas","sequence":"additional","affiliation":[{"name":"The University of Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Bodna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penny","family":"Harvey","sequence":"additional","affiliation":[{"name":"Northern Health, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Lim","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Wong","sequence":"additional","affiliation":[{"name":"Eastern Health, Australia"},{"name":"Royal Melbourne Hospital, Australia"},{"name":"The University of Melbourne, Australia"},{"name":"Monash University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Lui","sequence":"additional","affiliation":[{"name":"Austin Health, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang","family":"Lim","sequence":"additional","affiliation":[{"name":"The University of Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,9,9]]},"event":{"name":"9th International Advance Care Planning 2025 Conference, Gold Coast \/ Yugambeh Country, Australia, Hosted by Advance Care Planning Australia Abstracts Book"},"container-title":["Poster"],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/spcare-2025-ACP.92","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:25:52Z","timestamp":1757463952000},"score":7.626721,"resource":{"primary":{"URL":"https:\/\/spcare.bmj.com\/lookup\/doi\/10.1136\/spcare-2025-ACP.92"}},"issued":{"date-parts":[[2025,9]]},"references-count":0,"alternative-id":["10.1136\/spcare-2025-ACP.92"],"URL":"https:\/\/doi.org\/10.1136\/spcare-2025-acp.92","published":{"date-parts":[[2025,9]]}},{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T09:16:51Z","timestamp":1649063811228},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"suppl_1","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2017,7,1]]},"DOI":"10.1093\/geroni\/igx004.2999","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T19:32:50Z","timestamp":1498851170000},"page":"832-832","source":"Crossref","is-referenced-by-count":0,"title":["OLDER PEOPLE\u2019S UNDERSTANDING OF AND RECEPTIVENESS TO ACTIVITIES TO PREVENT COGNITIVE DECLINE"],"prefix":"10.1093","volume":"1","author":[{"given":"S.","family":"Pettigrew","sequence":"first","affiliation":[{"name":"Psychology, Curtin University, Perth, Western Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.I.","family":"Jongenelis","sequence":"additional","affiliation":[{"name":"Psychology, Curtin University, Perth, Western Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Biagioni","sequence":"additional","affiliation":[{"name":"Psychology, Curtin University, Perth, Western Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Talati","sequence":"additional","affiliation":[{"name":"Psychology, Curtin University, Perth, Western Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Newton","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Warburton","sequence":"additional","affiliation":[{"name":"La Trobe University, Perth, Western Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Jackson","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Worrall","sequence":"additional","affiliation":[{"name":"Psychology, Curtin University, Perth, Western Australia, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,6,30]]},"container-title":["Innovation in Aging"],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/innovateage\/article-pdf\/1\/suppl_1\/832\/26124593\/igx004.2999.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T12:41:28Z","timestamp":1540212088000},"score":7.6255293,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/innovateage\/article\/1\/suppl_1\/832\/3900048"}},"issued":{"date-parts":[[2017,6,30]]},"references-count":0,"journal-issue":{"issue":"suppl_1","published-online":{"date-parts":[[2017,6,30]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/geroni\/igx004.2999","ISSN":["2399-5300"],"issn-type":[{"value":"2399-5300","type":"electronic"}],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2017,6,30]]}},{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:48:04Z","timestamp":1782899284961,"version":"3.54.5"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012505","name":"Royal Perth Hospital Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n In Australia, older Aboriginal and Torres Strait Islander people have the highest prevalence of hearing loss, for which dedicated audiological services are available.<\/jats:p>\n However, there is limited research on the experiences older Aboriginal and Torres Strait Islander people have with hearing loss and audiological services. Therefore, this study aimed to consolidate existing literature with a scoping review, specifically on the above to identify gaps and guide future research.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n Ten databases, including electronic journal databases and government databases, were systematically searched. Additional studies were sought from article reference lists, review articles, conference abstracts and Google Scholar. We identified 540 records and 22 of them met our inclusion criteria. Our inclusion criteria constituted research of any design on the experiences of older Aboriginal and Torres Strait Islander people (aged 45+ years) with hearing loss and audiological services.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Seventeen studies reported on experiences with hearing loss, four studies reported on experiences with audiological services and one study reported on both experiences. Prevalence of hearing loss was estimated to be 20%\u201334% in older Aboriginal and Torres Strait Islander people; a discrepancy between self\u2010reported and objective hearing difficulties was also identified. Audiological services currently available to older Aboriginal and Torres Strait Islander people were also underutilised.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Future research on older Aboriginal and Torres Strait Islander people is required to uncover: (1) the reasons for underreported hearing loss; (2) types of hearing loss experienced; (3) barriers to accessing audiological services; and (4) best hearing\u2010loss management and rehabilitation practices.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/coa.14254","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:48:34Z","timestamp":1731631714000},"page":"191-204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Older Aboriginal and Torres Strait Islander People's Experiences With Hearing Loss and Audiological Services: A Scoping Review"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4484-0886","authenticated-orcid":false,"given":"Ayesha","family":"Chowdhury","sequence":"first","affiliation":[{"name":"School of Human Sciences The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0148-5604","authenticated-orcid":false,"given":"Rong","family":"Tian","sequence":"additional","affiliation":[{"name":"UWA Medical School The University of Western Australia Crawley Western Australia Australia"},{"name":"Ear Science Institute Australia Subiaco Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4480-2406","authenticated-orcid":false,"given":"Paul","family":"McIlhiney","sequence":"additional","affiliation":[{"name":"Ear Science Institute Australia Subiaco Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5814-4355","authenticated-orcid":false,"given":"Dona M. P.","family":"Jayakody","sequence":"additional","affiliation":[{"name":"Ear Science Institute Australia Subiaco Western Australia Australia"},{"name":"WA Centre for Health and Ageing The University of Western Australia Crawley Western Australia Australia"},{"name":"Centre for Ear Sciences The University of Western Australia Crawley Western Australia Australia"},{"name":"Curtin School of Allied Health Curtin University Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organisation \u201cDeafness and Hearing Loss \u201d 2023 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/deafness\u2010and\u2010hearing\u2010loss."},{"key":"e_1_2_12_3_1","unstructured":"Australian Institute of Health and Welfare \u201cEar and Hearing Health of Aboriginal and Torres Strait Islander People 2021 \u201d 2022 https:\/\/www.aihw.gov.au\/reports\/indigenous\u2010australians\/ear\u2010and\u2010hearing\u2010health\u2010of\u2010aboriginal\u2010torres\u2010strait\/summary."},{"issue":"4","key":"e_1_2_12_4_1","first-page":"1","article-title":"Review of Ear Health and Hearing Among Indigenous Australians","volume":"13","author":"Burns J. 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Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010629","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n The aims of this study were to determine the performance of a large language model (LLM) with a zero\u2010shot strategy for the classification of several factors relevant to the consideration of intravenous immunoglobulin (IVIg) weaning.<\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n In many cases, IVIg should be weaned to prevent excessive resource utilisation and adverse effects.<\/jats:p>\n <\/jats:sec>\n \n Methods and Materials<\/jats:title>\n A cohort study was conducted examining neurology outpatients receiving regular IVIg in a 2\u2010month period. Prespecified criteria were used to determine how many individuals were suitable for IVIg weaning. A LLM was applied to determine the level of performance with which the model could provide answers to the prespecified criteria.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In the inclusion period, 14 individuals were identified and four patients fulfilled the criteria for possible IVIg weaning. The total annual cost saving with IVIg weaning was conservatively estimated to be $84702.20 (1433.9\u2009g of IVIg annually). The LLM achieved an overall classification accuracy of 78.6% (11\/14) when a rule\u2010based approach was applied to the individual criteria that it extracted from notes.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Further research is indicated to determine the frequency with which patients suitable for IVIg weaning are identified at other centres and the degree to which LLM may be able to assist with this process.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tme.70020","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T09:15:02Z","timestamp":1762334102000},"page":"79-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intravenous immunoglobulin weaning evaluation with zero\u2010shot large language model classification"],"prefix":"10.1111","volume":"36","author":[{"given":"Emily","family":"Burton","sequence":"first","affiliation":[{"name":"Lyell McEwin Hospital Elizabeth Vale South Australia Australia"},{"name":"SA Health Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shrirajh","family":"Satheakeerthy","sequence":"additional","affiliation":[{"name":"SA Health Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudy","family":"Goh","sequence":"additional","affiliation":[{"name":"Lyell McEwin Hospital Elizabeth Vale South Australia Australia"},{"name":"SA Health Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Stretton","sequence":"additional","affiliation":[{"name":"Lyell McEwin Hospital Elizabeth Vale South Australia Australia"},{"name":"SA Health Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0023-6552","authenticated-orcid":false,"given":"Andrew E. 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Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534716020991?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534716020991?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2016.02.1811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:41:28Z","timestamp":1651210888000},"score":7.624171,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2016.02.1811"}},"issued":{"date-parts":[[2016,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1016\/j.juro.2016.02.1811"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2016.02.1811","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2016,4]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:18Z","timestamp":1753889838976,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Objective: To assess the impact of preventative therapies on the extent of coronary artery disease (CAD) in people with and without diabetes in a real-world setting.<\/jats:p>\n Research Design and Methods: Patient-level linked coronary angiography and hospital separation data at a large Australian tertiary referral hospital between 2013 and 2019 were obtained and a random sample of patient charts reviewed for medication use (renin-angiotensin system (RAS) inhibitors, statins and antiplatelets). Indication for angiography and extent of CAD were based on the original classification by treating cardiologists, classified as no disease, mild, moderate or severe. Propensity scores were estimated and used to weight in the ordinal logistic regression models. Models were fitted to assess trends in CAD severity in people with and without diabetes with adjusted odds ratios (adjOR) reported.<\/jats:p>\n Results: For 805 people identified in the coronary angiography database with medication use information available, 386(48%) were diagnosed with diabetes. Angiographic evidence of CAD was found in 297(71%) and 301(78%) of people without and with diabetes, respectively. People with diabetes were at an increased risk of more extensive CAD disease compared to people without diabetes (adjOR: 1.37 95% C.I. 1.00, 1.88). However, when adjusted for the use of RAS inhibitors, statins and antiplatelets there was no difference in the extent of CAD between people with and without diabetes (adjOR: 1.22 95% C.I. 0.87, 1.69).<\/jats:p>\n Conclusions: These findings highlight the increased risk that people with diabetes have for more extensive CAD than people without diabetes. Our results also suggest that with the aggressive and appropriate use of traditional cardiovascular disease preventative therapies it may be possible to significantly reduce the excess CAD burden observed in people with diabetes.<\/jats:p>\n \n Disclosure<\/jats:title>\n K.V. Kiburg: None. A.I. MacIsaac: None. G.E. McCluskey: None. V. Sundararajan: None. R. MacIsaac: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-417-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:52Z","timestamp":1592238592000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["417-P: Impact of Preventative Therapies on the Extent of Coronary Artery Disease in People with and without Diabetes"],"prefix":"10.2337","volume":"69","author":[{"given":"KATERINA V.","family":"KIBURG","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREW I.","family":"MACISAAC","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GEORGIA E.","family":"MCCLUSKEY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VIJAYA","family":"SUNDARARAJAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"MACISAAC","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, 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University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2002,1,4]],"date-time":"2002-01-04T00:00:00Z","timestamp":1010102400000},"content-version":"vor","delay-in-days":1313,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[1998,6,1]],"date-time":"1998-06-01T00:00:00Z","timestamp":896659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Letters in Applied Microbiology"],"published-print":{"date-parts":[[1998,6]]},"DOI":"10.1046\/j.1472-765x.1998.00363.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T09:55:30Z","timestamp":1047462930000},"page":"427-431","source":"Crossref","is-referenced-by-count":7,"title":["The comparative effects of nitrogen and oxygen on the microflora of beef steaks in carbon dioxide\u2010containing modified atmosphere vacuum skin\u2010packaging (MA\u2010VSP) systems"],"prefix":"10.1093","volume":"26","author":[{"family":"Coventry","sequence":"first","affiliation":[{"name":"Food Science Australia, Werribee, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Hickey","sequence":"additional","affiliation":[{"name":"Food Science Australia, Werribee, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Mawson","sequence":"additional","affiliation":[{"name":"Food Science Australia, Werribee, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Drew","sequence":"additional","affiliation":[{"name":"Food Science Australia, Werribee, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Wan","sequence":"additional","affiliation":[{"name":"Food Science Australia, Werribee, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Krause","sequence":"additional","affiliation":[{"name":"Food Science Australia, Werribee, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Boghossian","sequence":"additional","affiliation":[{"name":"Food Science Australia, Werribee, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,1,4]]},"container-title":["Letters in Applied Microbiology"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1046%2Fj.1472-765X.1998.00363.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1472-765X.1998.00363.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1046\/j.1472-765X.1998.00363.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1046\/j.1472-765X.1998.00363.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T12:08:29Z","timestamp":1676376509000},"score":7.623914,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/lambio\/article\/26\/6\/427\/6697202"}},"issued":{"date-parts":[[1998,6]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2002,1,4]]},"published-print":{"date-parts":[[1998,6]]}},"alternative-id":["10.1046\/j.1472-765X.1998.00363.x"],"URL":"https:\/\/doi.org\/10.1046\/j.1472-765x.1998.00363.x","archive":["Portico"],"ISSN":["0266-8254","1472-765X"],"issn-type":[{"value":"0266-8254","type":"print"},{"value":"1472-765X","type":"electronic"}],"published":{"date-parts":[[1998,6]]}},{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:11:39Z","timestamp":1759972299161,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"S8","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2023,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Cognitive reserve (CR) is thought to protect cognitive ability against neurodegenerative conditions, such as Alzheimer\u2019s disease, or other neurological insults. Because past research has studied the construct extensively in older adult populations, little is known about its development across the lifespan. The current study generated a dynamic CR index based on a modified residual approach utilised successfully in older adults (Reed et al., 2010; Bettcher et al., 2019), and examined its criterion and construct validity in a paediatric cohort comprising children both with and without ADHD.<\/jats:p><\/jats:sec>Method<\/jats:title>Archived longitudinal data collected across 2011\u20102019 from N = 115 children (MAge<\/jats:sub> = 10.48, SDAge<\/jats:sub> = 0.61, n = 72 [63%] male, n = 43 [37%] with ADHD) was obtained from the Murdoch Children\u2019s Research Institute. Static and dynamic CR were operationalised based on residual variance in (change in) fluid intellect (Matrix Reasoning) not explained by demographics (i.e., sex and age) or MRI\u2010based brain variables (i.e., grey matter volumes, white matter hypointensities [WMH], and hippocampal volumes). This index was subsequently used to predict relevant outcome variables (i.e., sustained attention, working memory, inhibition, word reading, and mathematical computation) to assess criterion validity at baseline and across time, while construct validity was assessed via interaction effects between CR, brain, and baseline\/longitudinal outcomes.<\/jats:p><\/jats:sec>Results<\/jats:title>Approximately 8% of the variance in fluid intellect was predicted by selected brain and demographics at baseline, with 14% predicted in the longitudinal model. CR at baseline predicted mathematical computation (p<.001), word reading (p = .012), and working memory ability (p<.001) at baseline. CR change only predicted change in word reading ability (p<.001); it was also found to moderate relationships between WMH volume change and word reading trajectory, and between WMH volume change and change in sustained attention performance.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our results suggest that CR can be modelled in children using a residual index, but with less validity than in older adults; weak criterion and construct validity were evident, although this should be tempered by the fact that there was minimal variance explained in the residualised variable. An adjusted model optimised for a paediatric cohort will form the basis of further inquiry into the study of CR in a developmental context.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.064872","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T06:25:12Z","timestamp":1686896712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modelling the developmental trajectories of cognitive reserve in children"],"prefix":"10.1002","volume":"19","author":[{"given":"Zubin","family":"Irani","sequence":"first","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Sheridan","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Silk","sequence":"additional","affiliation":[{"name":"Deakin University, Melbourne, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Weinborn","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon E","family":"Gavett","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,16]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.064872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:56:27Z","timestamp":1759956987000},"score":7.6237073,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.064872"}},"issued":{"date-parts":[[2023,6]]},"references-count":0,"journal-issue":{"issue":"S8","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/alz.064872"],"URL":"https:\/\/doi.org\/10.1002\/alz.064872","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"type":"print","value":"1552-5260"},{"type":"electronic","value":"1552-5279"}],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2023-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e064872"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:44Z","timestamp":1753889864764,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2022,6,1]]},"abstract":"Adipocyte lipolysis is tightly regulated to provide fatty acids when needed and this is suppressed postprandially by insulin. This regulation remains incompletely understood. We have identified the abhydrolase ABHD15 as a key player in this process together with the phosphodiesterase PDE3B. In the absence of either ABHD15 or PDE3B, insulin is not able to suppress lipolysis. ABHD15 and PDE3B form a complex and in response to insulin they are both phosphorylated by Akt and bind to the adaptor protein 14-3-3. Insertion of a constitutive 14-3-3 binding site into either ABHD15 or PDE3B results in complete suppression of lipolysis even under pro-lipolytic conditions. Notably, we have discovered that the kinase Akt interacts with ABHD15 and insulin and\/or 14-3-3 binding to ABHD15 abolishes the interaction. In summary we propose a model where ABHD15 binds to and suppresses the phosphodiesterase activity of PDE3B in the absence of insulin thereby facilitating unrestrained lipolysis and supply of fatty acids during starvation or crisis. Akt directly interacts with the ABHD15\/PDE3B complex leading to phosphorylation and 14-3-3 binding upon insulin stimulation, which activates a pool of PDE3B thus repressing PKA and the lipolytic drive.<\/jats:p>\n \n Disclosure<\/jats:title>\n J. Stoeckli: Research Support; Pfizer Inc. A. Zadoorian: None. G. Yang: None. D. E. James: Research Support; Eli Lilly and Company, Novo Nordisk, Pfizer Inc.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Pfizer Inc.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db22-202-lb","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:10:30Z","timestamp":1653973830000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["202-LB: Insulin Regulation of Lipolysis in Adipocytes"],"prefix":"10.2337","volume":"71","author":[{"given":"JACQUELINE","family":"STOECKLI","sequence":"first","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ARMELLA","family":"ZADOORIAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GUANG","family":"YANG","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID E.","family":"JAMES","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/202-LB\/145128\/202-LB-Insulin-Regulation-of-Lipolysis-in","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/202-LB\/145128\/202-LB-Insulin-Regulation-of-Lipolysis-in","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:10:31Z","timestamp":1653973831000},"score":7.623344,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/202-LB\/145128\/202-LB-Insulin-Regulation-of-Lipolysis-in"}},"issued":{"date-parts":[[2022,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db22-202-lb","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2022,6,1]]},"article-number":"202-LB"},{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:09:57Z","timestamp":1778159397518,"version":"3.51.4"},"reference-count":0,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["The Australian Educational and Developmental Psychologist"],"published-print":{"date-parts":[[2010,6,1]]},"DOI":"10.1375\/aedp.27.1.1","type":"journal-article","created":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T04:00:17Z","timestamp":1283313617000},"page":"1-19","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Profiling the College of Educational and Developmental Psychologists: An Examination of Demographics, Professional Practice, Attitudes and Professional Development Preferences"],"prefix":"10.1080","volume":"27","author":[{"given":"Janet","family":"Fletcher","sequence":"first","affiliation":[{"name":"The University of Western Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberley","family":"Bloor","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Crossman","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Thornton","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellie","family":"Briggs","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Hawkins","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Sammut","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kitri","family":"Cardwell","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,10,19]]},"container-title":["The Australian Educational and Developmental Psychologist"],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1375\/aedp.27.1.1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T18:58:09Z","timestamp":1636657089000},"score":7.623137,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1375\/aedp.27.1.1"}},"issued":{"date-parts":[[2010,6,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,6,1]]}},"alternative-id":["10.1375\/aedp.27.1.1"],"URL":"https:\/\/doi.org\/10.1375\/aedp.27.1.1","ISSN":["0816-5122","1839-2504"],"issn-type":[{"value":"0816-5122","type":"print"},{"value":"1839-2504","type":"electronic"}],"published":{"date-parts":[[2010,6,1]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2010","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]},{"indexed":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T01:41:49Z","timestamp":1656121309161},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"13_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2017,7,1]]},"abstract":"Abstract<\/jats:title>\n Cytotoxic T lymphocytes (CTLs) recognize mutated tumor proteins (neo-antigens) and are important for anti-tumor immunity, especially in the context of immune checkpoint blockade immunotherapy (ICPB). Positive outcomes to ICPB are associated with high neo-antigen loads and with neo-antigen specific CTL responses. However only around 20% of patients respond to ICPB.<\/jats:p>\n In order to examine ways in which the non-responders might become responders we examined several strategies to improve response rates, using anti-CTLA4 initially as the ICPB therapy in BALB\/c mice in which Uqcrc2 has been defined as a DNA\/RNAseq-identified neo-antigen in AB1 tumor lines induced by a relevant human carcinogen(1).<\/jats:p>\n a) We first examined therapy-induced changes in T-cell responses against Uqcrc2. Anti-CTLA4 alone increased the magnitude of responses against Uqcrc2. Anti-CTLA4 combined with anti-GITR induced determinant spreading, unmasked responses against a new neo-antigen UNC45A that was undetectable during normal tumour growth. Immunogenic chemotherapy also unmasked responses against UNC45A, suggesting that subdominant neo-antigens can be unmasked by the appropriate immunotherapy.<\/jats:p>\n b) We then evaluated neo-antigen vaccination strategies. Uqcrc2 vaccination only protected against tumor growth when administered in combination with partial Treg depletion (Foxp3.DTR mice), suggesting that neo-antigen vaccination will only be maximally effective when administered in combination with therapies that modulate existing immune restraints, including Tregs.<\/jats:p>\n c) We determined optimal anatomical location for tracking neo-antigen CTL responses and identified the draining lymph node as an optimal, though not exclusive, location for response testing compared to blood or tumor.<\/jats:p>\n We are currently examining these observations using sequencing-defined neo-antigens in our patients and will present data on changes in human neo-antigen responses to therapy. These observations have important translational implications for identification of key neo-antigens, choice of therapy and monitoring of anti-tumor responses.<\/jats:p>\n 1.<\/jats:p>\n J. Creaney et al., Strong spontaneous tumor neoantigen responses induced by a natural human carcinogen. Oncoimmunology 4, e1011492 (2015).<\/jats:p>\n Citation Format: Bruce W. Robinson, Shaokang Ma, Jonathan Chee, Craig Rive, Paula Van Miert, Rob A. Holt, Jenette Creaney. Augmenting and broadening T cell responses against mutated tumour neo-antigens [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 608. doi:10.1158\/1538-7445.AM2017-608<\/jats:p>","DOI":"10.1158\/1538-7445.am2017-608","type":"journal-article","created":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T21:44:40Z","timestamp":1501537480000},"page":"608-608","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 608: Augmenting and broadening T cell responses against mutated tumour neo-antigens"],"prefix":"10.1158","volume":"77","author":[{"given":"Bruce W.","family":"Robinson","sequence":"first","affiliation":[{"name":"1University of Western Australia, Western Australia, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaokang","family":"Ma","sequence":"additional","affiliation":[{"name":"1University of Western Australia, Western Australia, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Chee","sequence":"additional","affiliation":[{"name":"1University of Western Australia, Western Australia, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Rive","sequence":"additional","affiliation":[{"name":"1University of Western Australia, Western Australia, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Van","family":"Miert","sequence":"additional","affiliation":[{"name":"1University of Western Australia, Western Australia, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob A.","family":"Holt","sequence":"additional","affiliation":[{"name":"2University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenette","family":"Creaney","sequence":"additional","affiliation":[{"name":"1University of Western Australia, Western Australia, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/77\/13_Supplement\/608\/621877\/Abstract-608-Augmenting-and-broadening-T-cell","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/77\/13_Supplement\/608\/621877\/Abstract-608-Augmenting-and-broadening-T-cell","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T01:26:31Z","timestamp":1656120391000},"score":7.623073,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/77\/13_Supplement\/608\/621877\/Abstract-608-Augmenting-and-broadening-T-cell"}},"issued":{"date-parts":[[2017,7,1]]},"references-count":0,"journal-issue":{"issue":"13_Supplement","published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2017-608","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2017,7,1]]}},{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T03:47:19Z","timestamp":1764301639108,"version":"3.46.0"},"reference-count":40,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"unspecified","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,11,4]]},"published-print":{"date-parts":[[2025,11]]},"abstract":"\n Objective<\/jats:title>\n To determine age-specific and age-standardised incidence trends of acute rheumatic fever (ARF) or rheumatic heart disease (RHD) among Indigenous Western Australians aged less than 35 years of age.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A population-based retrospective cohort study with linked data analysis.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Western Australian hospital admissions (1996\u20132022) and RHD notifications to the state-based register (2011\u20132015).<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Patients, both Indigenous and non-Indigenous aged <35 years at diagnosis with incident ARF or RHD.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 1746 incident ARF\/RHD cases, 1526 (87%) were Indigenous peoples, with the highest rates observed in patients aged 5\u201314 years, with an annual estimated increase of 4.3% (95% CI 3.2% to 5.2%). The 0\u20134 years age group experienced an annual increase in incidence rates of 4.8% (95% CI 1.4% to 8.2%). Overall, Indigenous patients experienced an annual increase of 1.9% (95% CI 1.3% to 2.6%) from 1996 to 2022. However, most cases (n=894) were identified after multiple significant policy developments (2011\u20132022) with an annual increase of 5.7% (95% CI 3.7% to 7.5%) for this period.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Increasing trends of incident ARF\/RHD were observed in Indigenous patients aged under 15 years, with the greatest annual increments observed after policy implementation for disease reporting and awareness in the period from 2011 to 2022. Improvement in case ascertainment of ARF\/RHD may be contributing towards increasing trends with improved reporting and monitoring of incident cases in very young Indigenous Australians more recently.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-107621","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T03:45:39Z","timestamp":1764301539000},"page":"e107621","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Trends in incident acute rheumatic fever or rheumatic heart disease in Indigenous youth in Western Australia: a retrospective cohort study"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2812-0744","authenticated-orcid":false,"given":"Bradley","family":"MacDonald","sequence":"first","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Department of General Paediatrics, Perth Children\u2019s Hospital, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nita","family":"Sodhi-Berry","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Stacey","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Robinson","sequence":"additional","affiliation":[{"name":"Perth Children\u2019s Hospital, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Carapetis","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"},{"name":"The Kids Research Institute Australia, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asha C","family":"Bowen","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"},{"name":"The Kids Research Institute Australia, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-5561","authenticated-orcid":false,"given":"Charley","family":"Budgeon","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Nedkoff","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5287-5819","authenticated-orcid":false,"given":"Judith M","family":"Katzenellenbogen","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"2025112719454753000_15.11.e107621.1","doi-asserted-by":"crossref","first-page":"15084","DOI":"10.1038\/nrdp.2015.84","article-title":"Acute rheumatic fever and rheumatic heart disease","volume":"2","author":"Carapetis","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2025112719454753000_15.11.e107621.2","doi-asserted-by":"crossref","DOI":"10.1007\/s11936-017-0513-y","article-title":"Group A Streptococcus, Acute Rheumatic Fever and Rheumatic Heart Disease: Epidemiology and Clinical Considerations","volume":"19","author":"Z\u00fchlke","year":"2017","journal-title":"Curr Treat Options Cardiovasc 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Creating the visual illusion of touch can improve tactile perception in healthy subjects. Objective. We were interested in seeing if creating the illusion of touch in an insensate area could improve sensation in that area. Methods. Fourteen people with chronic numbness participated in a randomized crossover experiment. The 4 conditions were the following: ( a) stimulation over the unaffected limb with mirror visual feedback (experimental condition), ( b) stimulation over the affected limb with mirror visual feedback, ( c) stimulation over the unaffected limb without mirror visual feedback, and ( d) stimulation over the affected limb without mirror visual feedback. Participants were assessed before and after each condition using the Ten-Test and mechanical detection thresholds. Data were analyzed using linear mixed models. Result. Only the experimental condition produced a change in the Ten-Test (mean difference = \u22121.1; 95% confidence interval = \u22121.8 to \u22120.4; P = .003), corresponding to a 24% improvement in sensation. No differences were observed for any condition in mechanical detection thresholds. Conclusion. Creating the illusion of touch may improve sensory function in areas of chronic numbness. This preliminary finding adds to the growing body of evidence supporting the use of techniques that directly target cortical function in people with peripheral nerve injury.<\/jats:p>","DOI":"10.1177\/1545968314524827","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T21:20:09Z","timestamp":1393276809000},"page":"797-799","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Illusory Touch Temporarily Improves Sensation in Areas of Chronic Numbness"],"prefix":"10.1177","volume":"28","author":[{"given":"Benedict Martin","family":"Wand","sequence":"first","affiliation":[{"name":"The University of Notre Dame Australia, Fremantle, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha Eve","family":"Stephens","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Effie Ida Marquita","family":"Mangharam","sequence":"additional","affiliation":[{"name":"The University of Notre Dame Australia, Fremantle, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela Jane","family":"George","sequence":"additional","affiliation":[{"name":"The University of Notre Dame Australia, Fremantle, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max K.","family":"Bulsara","sequence":"additional","affiliation":[{"name":"The University of Notre Dame Australia, Fremantle, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil Edward","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"Brunel University, Uxbridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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They argue that more flexible and entrepreneurial approaches to conservation are needed. While some of the approaches they promote may work in particular situations, we believe their proposal risks unintended and detrimental social and ecological consequences by presenting them as global solutions to complex political, economic, social and ethical problems that are context\u2010dependent. Here we argue that the authors inadequately considers the following core issues of biodiversity conservation, namely: (1) the structural causes of biodiversity depletion and the responsibilities of key actors; (2) the questions around what should be conserved, the processes by which biodiversity is valued, and who has the legitimate authority to value it; (3) the fact that new tools, technologies and innovative approaches are unsuitable as guiding principles to solve complex, context\u2010dependent social\u2010ecological problems; (4) the challenges of choosing relevant interventions, given experts\u2019 limited ability to \u2018manage for change and evolution\u2019; and (5) the risks associated with promoting a utilitarian approach and a neoliberal governance model for conservation at the global scale.<\/jats:p>","DOI":"10.1111\/1758-5899.12415","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T18:38:06Z","timestamp":1489516686000},"page":"253-256","source":"Crossref","is-referenced-by-count":12,"title":["Why Politics and Context Matter in Conservation Policy"],"prefix":"10.1111","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0226-634X","authenticated-orcid":false,"given":"Florence L. 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Wellbore stability was also a concern here because of the narrow equivalent circulating density margin and the unconsolidated nature of the reservoir rocks.<\/jats:p>\n During the planning phase, several new technologies were selected to help tackle these challenges and ensure project success. First, a new measurement-while-drilling tool that could provide a continuous definitive dynamic survey while drilling was included. This could give definite dynamic surveys in real time, enabling the most accurate curve in the most complex 3D well profiles, while also eliminating the static survey time and reducing time to total depth. Second, a high-definition ultradeep-resistivity tool (HD-UDR) was used for mapping the reservoir layers and OWC more than 30 m away from the wellbore for geosteering the wellbores within the target zone. Third, a high-definition deep resistivity tool (HD-DR) was used for providing closer-to-bit high-resolution delineation of nearby boundaries. 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Post-drill resistivity cubes along the lateral were generated, opening possibilities for integration with existing reservoir models.<\/jats:p>\n Despite the significant challenges the team faced, the project execution went smoothly, and all four laterals were successfully drilled and completed, achieving the expected production rate and reserves. 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R. Soc. B."],"published-print":{"date-parts":[[2016,7,13]]},"abstract":"A comprehensive description of the spectral characteristics of retinal photoreceptors in palaeognaths is lacking. Moreover, controversy exists with respect to the spectral sensitivity of the short-wavelength-sensitive-1 (SWS1) opsin-based visual pigment expressed in one type of single cone: previous microspectrophotometric (MSP) measurements in the ostrich (Struthio camelus<\/jats:italic>) suggested a violet-sensitive (VS) SWS1 pigment, but all palaeognath SWS1 opsin sequences obtained to date (including the ostrich) imply that the visual pigment is ultraviolet-sensitive (UVS). In this study, MSP was used to measure the spectral properties of visual pigments and oil droplets in the retinal photoreceptors of the emu (Dromaius novaehollandiae<\/jats:italic>). Results show that the emu resembles most other bird species in possessing four spectrally distinct single cones, as well as double cones and rods. Four cone and a single rod opsin are expressed, each an orthologue of a previously identified pigment. The SWS1 pigment is clearly UVS (wavelength of maximum absorbance [\u03bb<\/jats:italic>max<\/jats:sub>] = 376 nm), with key tuning sites (Phe86 and Cys90) consistent with other vertebrate UVS SWS1 pigments. Palaeognaths would appear, therefore, to have UVS SWS1 pigments. As they are considered to be basal in avian evolution, this suggests that UVS is the most likely ancestral state for birds. The functional significance of a dedicated UVS cone type in the emu is discussed.<\/jats:p>","DOI":"10.1098\/rspb.2016.1063","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T09:08:24Z","timestamp":1467796104000},"page":"20161063","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Visual pigments in a palaeognath bird, the emuDromaius novaehollandiae<\/i>: implications for spectral sensitivity and the origin of ultraviolet vision"],"prefix":"10.1098","volume":"283","author":[{"given":"Nathan S.","family":"Hart","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Macquarie University, North Ryde, New South Wales 2109, Australia"},{"name":"School of Animal Biology, University of Western Australia, Crawley, Western Australia 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica K.","family":"Mountford","sequence":"additional","affiliation":[{"name":"School of Animal Biology, University of Western Australia, Crawley, Western Australia 6009, Australia"},{"name":"Oceans Institute, University of Western Australia, Crawley, Western Australia 6009, Australia"},{"name":"Lions Eye Institute, University of Western Australia, Nedlands, Western Australia 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne I. 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A 2\u2010D panoramic radiograph or a 3\u2010D cone\u2010beam computed tomography (CBCT<\/jats:styled-content>) scan can be used to visualize the proximity of the third molar to the mandibular canal. We aimed to correlate panoramic indicators of risk with the incidence of contact between these two structures on CBCT<\/jats:styled-content> scans.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients were selected from a Western Australian population if they had a panoramic radiograph that illustrated signs of risk of inferior alveolar nerve injury and had a CBCT<\/jats:styled-content> scan on file. Statistically\u2010significant relationships between the relative position and distance between the mandibular canal and third molar were investigated using \u03c72<\/jats:sup>\u2010test and Fisher's exact test in Stata version 13.<\/jats:p><\/jats:sec>Results<\/jats:title>Within the Western Australian sample (N\u00a0=\u00a0100), of six possible panoramic indicators of risk, two were significantly associated with contact between the tooth and mandibular canal on CBCT<\/jats:styled-content>: (a) interruption of the radiographic white line of the canal; and (b) darkening of the root(s).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Two panoramic radiograph risk signs are significantly more likely to indicate contact on the CBCT<\/jats:styled-content> scans: interruption of the white line and darkening of the root(s). Further research is required to develop CBCT<\/jats:styled-content> prescription guidelines for surgical planning.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12323","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T04:38:39Z","timestamp":1517805519000},"source":"Crossref","is-referenced-by-count":15,"title":["Inferior alveolar nerve injury: Correlation between indicators of risk on panoramic radiographs and the incidence of tooth and mandibular canal contact on cone\u2010beam computed tomography scans in a Western Australian population"],"prefix":"10.1111","volume":"9","author":[{"given":"Kate L.","family":"Winstanley","sequence":"first","affiliation":[{"name":"Oral Health Centre of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Otway","sequence":"additional","affiliation":[{"name":"Oral Health Centre of Western Australia Perth Western Australia 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Research shows that LA models may be biased against students of certain demographic subgroups. Although fairness has gained significant attention in the broader machine learning (ML) community in the last decade, it is only recently that attention has been paid to fairness in LA. Furthermore, the decision on which unfairness mitigation algorithm or metric to use in a particular context remains largely unknown. On this premise, we performed a comparative evaluation of some selected unfairness mitigation algorithms regarded in the fair ML community to have shown promising results. Using a 3\u2010year program dropout data from an Australian university, we comparatively evaluated how the unfairness mitigation algorithms contribute to ethical LA by testing for some hypotheses across fairness and performance metrics. Interestingly, our results show how data bias does not always necessarily result in predictive bias. Perhaps not surprisingly, our test for fairness\u2010utility tradeoff shows how ensuring fairness does not always lead to drop in utility. Indeed, our results show that ensuring fairness might lead to enhanced utility under specific circumstances. Our findings may to some extent, guide fairness algorithm and metric selection for a given context.<\/jats:p>\n <\/jats:sec>\n \n \n \n \n \n Practitioner notes<\/jats:title>\n <\/jats:caption>\n \n What is already known about this topic\n \n \n LA is increasingly being used to leverage actionable insights about students and drive student success.<\/jats:p>\n <\/jats:list-item>\n \n LA models have been found to make discriminatory decisions against certain student demographic subgroups\u2014therefore, raising ethical concerns.<\/jats:p>\n <\/jats:list-item>\n \n Fairness in education is nascent. Only a few works have examined fairness in LA and consequently followed up with ensuring fair LA models.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n \n What this paper adds\n \n \n A juxtaposition of unfairness mitigation algorithms across the entire LA pipeline showing how they compare and how each of them contributes to fair LA.<\/jats:p>\n <\/jats:list-item>\n \n Ensuring ethical LA does not always lead to a dip in performance. Sometimes, it actually improves performance as well.<\/jats:p>\n <\/jats:list-item>\n \n Fairness in LA has only focused on some form of outcome equality, however equality of outcome may be possible only when the playing field is levelled.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n \n Implications for practice and\/or policy\n \n \n Based on desired notion of fairness and which segment of the LA pipeline is accessible, a fairness\u2010minded decision maker may be able to decide which algorithm to use in order to achieve their ethical goals.<\/jats:p>\n <\/jats:list-item>\n \n LA practitioners can carefully aim for more ethical LA models without trading significant utility by selecting algorithms that find the right balance between the two objectives.<\/jats:p>\n <\/jats:list-item>\n \n Fairness enhancing technologies should be cautiously used as guides\u2014not final decision makers. Human domain experts must be kept in the loop to handle the dynamics of transcending fair LA beyond equality to equitable LA.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bjet.13217","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T21:30:36Z","timestamp":1649799036000},"page":"822-843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["How do the existing fairness metrics and unfairness mitigation algorithms contribute to ethical learning analytics?"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5723-2564","authenticated-orcid":false,"given":"Oscar Blessed","family":"Deho","sequence":"first","affiliation":[{"name":"UniSA STEM University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4794-8339","authenticated-orcid":false,"given":"Chen","family":"Zhan","sequence":"additional","affiliation":[{"name":"UniSA STEM University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9023-1878","authenticated-orcid":false,"given":"Jiuyong","family":"Li","sequence":"additional","affiliation":[{"name":"UniSA STEM University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0794-0404","authenticated-orcid":false,"given":"Jixue","family":"Liu","sequence":"additional","affiliation":[{"name":"UniSA STEM University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2843-5738","authenticated-orcid":false,"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"UniSA STEM University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9732-4313","authenticated-orcid":false,"given":"Thuc","family":"Duy Le","sequence":"additional","affiliation":[{"name":"UniSA STEM University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"254","article-title":"Machine bias: There's software used across the country to predict future criminals. 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However, challenges remain in integrating AI, natural language processing (NLP) and free text data to enhance sepsis diagnosis at emergency department (ED) triage. This study aimed to evaluate the effectiveness of AI in improving sepsis diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective cohort study analysed data from 134\u2009266 patients admitted to the ED and subsequently hospitalised between 1 January 2016 and 31 December 2021. The data set comprised 10 variables and free-text triage comments, which underwent tokenisation and processing using a bag-of-words model. We evaluated four traditional NLP classifier models, including logistic regression, LightGBM, random forest and neural network. We also evaluated the performance of the BERT classifier. We used area under precision-recall curve (AUPRC) and area under the curve (AUC) as performance metrics.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Random forest exhibited superior predictive performance with an AUPRC of 0.789 (95% CI: 0.7668 to 0.8018) and an AUC of 0.80 (95% CI: 0.7842 to 0.8173). Using raw text, the BERT model achieved an AUPRC of 0.7542 (95% CI: 0.7418 to 0.7741) and AUC of 0.7735 (95% CI: 0.7628 to 0.8017) for sepsis prediction. Key variables included ED treatment time, patient age, arrival-to-treatment time, Australasian Triage Scale and visit type.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n This study demonstrates AI, particularly random forest and BERT classifiers, for early sepsis detection in EDs using free-text patient concerns.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Incorporating free text into machine learning improved diagnosis and identified missed cases, enhancing sepsis prediction in the ED with an AI-powered clinical decision support system. Large, prospective studies are needed to validate these findings.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjhci-2024-101354","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T05:30:17Z","timestamp":1757914217000},"page":"e101354","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Automated sepsis prediction from unstructured electronic health records using natural language processing: a retrospective cohort study"],"prefix":"10.1136","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3444-3841","authenticated-orcid":false,"given":"Lipi","family":"Mishra","sequence":"first","affiliation":[{"name":"Intensive Care Unit, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowmya Muchukunte","family":"Ramaswamy","sequence":"additional","affiliation":[{"name":"Heailthigence Pty, Perth, 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The ability to afford, access and acquire nutritionally adequate and culturally appropriate foods could play a role in the risk of developing T2D. Internationally, studies have looked at the association between T2D and food insecurity, yet no systematic review of the literature has been conducted. This systematic review aims to determine the relationship between food insecurity and T2D in children and adolescents, including Indigenous and culturally and linguistically diverse groups.<\/jats:p>\n Research Method: PubMed, MEDLINE (Ovid), CINHAL Plus with full text (EBSCO) and Cochrane Library databases were searched to identify the available literature. The search was restricted by publication date of 1990 - present, English language and human studies. Children (aged 1-18 years) diagnosed with either impaired glucose tolerance (IGT) or T2D and experience food insecurity, were included in the systematic review. Study selection, data extraction and synthesis and risk of bias assessment was completed by two independent reviewers.<\/jats:p>\n Results: A total of 10 studies comprising of 47,085 participants were included in the systematic review. Eight studies found an association between food insecurity and T2D, however, this association varied between studies. Different methodologies were used to measure food insecurity, IGT and T2D prevalence, which is a potential factor for the variation in the association within the selected studies.<\/jats:p>\n Conclusion: Evidence suggests the ability to afford, access and acquire nutritionally adequate and culturally appropriate foods is associated with IGT and T2D in children and adolescents. More longitudinal cohort studies on a larger, more representative sample need to be conducted to determine the extent of this relationship.<\/jats:p>\n \n Disclosure<\/jats:title>\n J. Blackburn: None. H. Bres: None. G. Devenish: None. A. 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Vocational education and training, education, and behavioural change programme participation in custody and demographic and risk assessment data were provided by correctional services in four Australian states for 10,834 Australian prisoners released from custody in 2010\u20132011. This information was used to predict returns to custody by 2015\u20132016. Overall, the results showed that participating in vocational education and training in custody contributed to the likelihood of remaining custody free at two and five years post-release for both male and female prisoners. However, for males the relationship was moderated by risk level. 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It is the first stratigraphic test of the Carrara Sub-basin, a recently discovered depocentre in the South Nicholson region. The drill hole intersected Cambrian and Proterozoic sediments consisting of organic-rich black shales and a thick sequence of interbedded black shales and silty-sandstones with hydrocarbon shows. A comprehensive analytical program carried out by Geoscience Australia on the recovered continuous core from 283\u2009m to total depth at 1751\u2009m provides critical data for understanding this area. Using data from this drilling campaign, thermal history modelling was undertaken to provide an estimate of the time-temperature maxima that the sub-basin has experienced, contributing to an understanding of hydrocarbon maturity. Kerogen kinetics are used to estimate the petroleum prospectivity of the sub-basin and attempt to understand the timing and nature of hydrocarbon generation. Combined, these newly modelled data provide insights into the resource potential of this frontier Proterozoic\u2013Paleozoic hydrocarbon province, delivering foundational data to support explorers across the eastern Northern Territory and northwest Queensland.<\/jats:p>","DOI":"10.1071\/aj22048","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T20:13:39Z","timestamp":1683749619000},"page":"S263-S268","source":"Crossref","is-referenced-by-count":1,"title":["Thermal history of the Carrara Sub-basin: insights from modelling of the NDI Carrara 1 drill hole"],"prefix":"10.1071","volume":"63","author":[{"given":"Tehani J.","family":"Palu","sequence":"first","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Grosjean","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuqi","family":"Wang","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Boreham","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam H. E.","family":"Bailey","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"2025122722255327300_R1"},{"key":"2025122722255327300_R2"},{"key":"2025122722255327300_R3"},{"key":"2025122722255327300_R4"},{"key":"2025122722255327300_R5"},{"key":"2025122722255327300_R6"},{"key":"2025122722255327300_R7"},{"key":"2025122722255327300_R8"},{"key":"2025122722255327300_R9"}],"container-title":["The APPEA Journal"],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/63\/2\/S263\/472669\/aj22048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/63\/2\/S263\/472669\/aj22048.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T03:25:57Z","timestamp":1766892357000},"score":7.619399,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/ep\/article\/63\/2\/S263\/77453\/Thermal-history-of-the-Carrara-Sub-basin-insights"}},"issued":{"date-parts":[[2023,5,11]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,5,11]]}},"URL":"https:\/\/doi.org\/10.1071\/aj22048","ISSN":["1326-4966","2206-8996"],"issn-type":[{"type":"print","value":"1326-4966"},{"type":"electronic","value":"2206-8996"}],"published":{"date-parts":[[2023,5,11]]}},{"indexed":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T05:25:51Z","timestamp":1734153951980,"version":"3.30.2"},"reference-count":0,"publisher":"Design Research Society","content-domain":{"domain":[],"crossmark-restriction":false},"DOI":"10.21606\/iasdr.2023.539","type":"proceedings-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T07:09:40Z","timestamp":1696489780000},"source":"Crossref","is-referenced-by-count":0,"title":["Can\u2019t spell \u2018medicine\u2019 without \u2018me\u2019: Finding the spirit of co-design in multidisciplinary collaboration"],"prefix":"10.21606","author":[{"given":"Christopher","family":"Thornton","sequence":"first","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myra","family":"Thiessen","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renly","family":"Lim","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Stanek","family":"Stanek","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Kalisch","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9056","published-online":{"date-parts":[[2023,10,9]]},"event":{"name":"IASDR 2023: Life-Changing Design","acronym":"IASDR2023"},"container-title":["IASDR 2023: Life-Changing Design"],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T15:50:58Z","timestamp":1734105058000},"score":7.619399,"resource":{"primary":{"URL":"https:\/\/dl.designresearchsociety.org\/iasdr\/iasdr2023\/fullpapers\/207"}},"issued":{"date-parts":[[2023,10,9]]},"references-count":0,"URL":"https:\/\/doi.org\/10.21606\/iasdr.2023.539","published":{"date-parts":[[2023,10,9]]}},{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T12:08:44Z","timestamp":1750421324608},"reference-count":0,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"15_suppl","funder":[{"name":"None"}],"content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2021,5,20]]},"abstract":" e18628 <\/jats:p> Background: At the start of the COVID-19 pandemic, a plan for cancer management during a pandemic did not exist. It soon became clear that without proper planning, cancer outcomes would worsen. Cancer patients are at increased risk of COVID-19 infection, morbidity, and mortality. Health sectors internationally reduced or paused non-urgent cancer care to protect cancer patients from COVID-19. However, disproportionate delays in screening, diagnosis, and treatment can unduly impact cancer outcomes, and backlogs can further burden a strained health system. Tailored approaches to cancer management are required which balance health resource availability along with the risks of exposure and benefits of treatment. Australia\u2019s relatively low COVID-19 case numbers afforded Cancer Australia an opportunity to proactively plan for optimal cancer management during this, and future, pandemics. Methods: Cancer Australia\u2019s Cancer care in the time of COVID-19: A conceptual framework for the management of cancer during a pandemic (the framework) maps evidence-based cancer care considerations in relation to a health system\u2019s capacity across acute and recovery pandemic phases, in relation to steps of the cancer care pathway. The framework promotes infection control and resource prioritisation in the context of innovative care models, triaging approaches and individualised treatment plans, underpinned by effective communication and shared decision-making. Results: The framework supports health system planning and risk-stratified approaches to guide decision-making and improve cancer outcomes. Many aspects of cancer care are recommended to continue (to varying degrees) in most pandemic phases, with modifications or pauses in some aspects of care as the pandemic curve approaches or exceeds health system capacity. Principles of the framework were employed during the second wave of COVID-19 in the Australian state of Victoria, with continuation of cancer screening programs, diagnostic investigations, and treatments wherever it was safe to do so. This resulted in reductions in cancer services and treatment being relatively smaller than in the first wave. Conclusions: Cancer management in a pandemic is not a one-size-fits-all. Countries and jurisdictions need to tailor cancer care according to the risk of the health system becoming overwhelmed. The framework guides optimal cancer care to improve outcomes for people with cancer, while minimising COVID-19 infection. As further evidence becomes available from this pandemic or in future pandemics, this framework can be refined to inform ongoing and future pandemic health system planning. <\/jats:p>","DOI":"10.1200\/jco.2021.39.15_suppl.e18628","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T14:28:38Z","timestamp":1622644118000},"page":"e18628-e18628","update-policy":"http:\/\/dx.doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Cancer care in the time of COVID-19: A conceptual framework to improve cancer outcomes during a pandemic."],"prefix":"10.1200","volume":"39","author":[{"given":"Vivienne","family":"Milch","sequence":"first","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleola","family":"Anderiesz","sequence":"additional","affiliation":[{"name":"Cancer Australia, Surry Hills, NSW, 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super duplex stainless steel, led to an extensive root cause failure analysis. The components showed a single longitudinal crack along a swaged section, which arrested toward its thicker end. The brittle nature of the fracture surface, calcareous deposits on the component, and exposure to cathodic protection suggested hydrogen-induced stress cracking\u2014a form of environmentally assisted cracking\u2014as a plausible failure mechanism. Thus, the three causative factors promoting hydrogen-induced stress cracking, namely, a susceptible microstructure, a hydrogen bearing environment, as well as sufficiently high applied and residual stresses in the material were the focus of this investigation. This work details the material characterization work and presents a possible failure mechanism. The results showed that the failure developed from a combination of factors, typical for hydrogen-induced stress cracking. The measured hydrogen content in parts of the material exceeded 40\u00a0ppm, more than an order of magnitude higher than what is normally expected in super duplex stainless steels. Additionally, a highly anisotropic, coarse microstructure was observed, which in combination with the introduced cold-work from the swaging process and potential stress raisers from design and machining could have facilitated crack initiation, ultimately leading to the failure of the component. This hypothesis was reinforced by the presence of secondary cracks along the main, brittle fracture surface. Furthermore, mechanical testing results showed a detrimental effect on the material\u2019s properties due to the presence of residual hydrogen and the swaging operation.<\/jats:p>","DOI":"10.5006\/3192","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T01:37:55Z","timestamp":1554341875000},"page":"824-838","source":"Crossref","is-referenced-by-count":17,"title":["Hydrogen-Induced Stress Cracking of Swaged Super Duplex Stainless Steel Subsea Components"],"prefix":"10.5006","volume":"75","author":[{"given":"M.","family":"Sofia Hazarabedian","sequence":"first","affiliation":[{"name":"*Curtin University, Perth, Western Australia, 6102 Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Viereckl","sequence":"additional","affiliation":[{"name":"*Curtin University, Perth, Western Australia, 6102 Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakaria","family":"Quadir","sequence":"additional","affiliation":[{"name":"*Curtin University, Perth, Western Australia, 6102 Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry","family":"Leadbeater","sequence":"additional","affiliation":[{"name":"*Curtin University, Perth, Western Australia, 6102 Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Golovanevskiy","sequence":"additional","affiliation":[{"name":"*Curtin University, Perth, Western Australia, 6102 Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skjalg","family":"Erdal","sequence":"additional","affiliation":[{"name":"**A60N, Perth, Western Australia, 6000 Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Georgeson","sequence":"additional","affiliation":[{"name":"**A60N, Perth, Western Australia, 6000 Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Iannuzzi","sequence":"additional","affiliation":[{"name":"*Curtin University, Perth, Western Australia, 6102 Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2917","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"key":"2025031810442440300_i0010-9312-75-7-3192-r1","first-page":"151","article-title":"\u201cSuper Duplex Stainless Steels: Structure and Properties,\u201d","author":"Charles","year":"1991"},{"issue":"6","key":"2025031810442440300_i0010-9312-75-7-3192-r2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.5006\/2159","volume":"73","author":"Skar","year":"2017","journal-title":"Corrosion"},{"key":"2025031810442440300_i0010-9312-75-7-3192-r3","article-title":"\u201cUse of Duplex Stainless Steels in the Oil Refining Industry\u201d","author":"API TR 938-C","year":"2015"},{"key":"2025031810442440300_i0010-9312-75-7-3192-r4","first-page":"495","article-title":"\u201cStainless Steels,\u201d","author":"Krauss","year":"2005","journal-title":"Steels: Processing, Structure, and Performance"},{"issue":"8","key":"2025031810442440300_i0010-9312-75-7-3192-r5","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1179\/mst.1992.8.8.685","volume":"8","author":"Nilsson","year":"1992","journal-title":"Mater. 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Historically, the understanding of plays in this region were largely model driven and therefore the ground-truthing of depositional environments (DE) and gross depositional environments (GDE) are critical. This aspect has been investigated for the Sherbrook Supersequence (SS) by the integration of legacy wireline and core data, with regional 2D seismic facies mapping of new and reprocessed data from Geoscience Australia\u2019s 2020 Otway Basin seismic program. Core observations were matched to wireline logs and seismic facies with resulting well-based DE interpretations calibrated to seismic resolution Regional GDE intervals. Integration of well and seismic observations led to the compilation of a basin-wide Regional GDE map for the Sherbrook SS. This GDE map indicates the distribution of Sherbrook SS play elements such as source rock, seal and reservoir, especially across the Deep-water Otway Basin where well data is sparse.<\/jats:p>","DOI":"10.1071\/aj22090","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T20:13:39Z","timestamp":1683749619000},"page":"S215-S220","source":"Crossref","is-referenced-by-count":2,"title":["Cretaceous depositional environment interpretation of offshore Otway Basin cores and wireline logs; application to the generation of basin-scale gross depositional environment maps"],"prefix":"10.1071","volume":"63","author":[{"given":"Chris","family":"Cubitt","sequence":"first","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Abbott","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Bernardel","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merrie-Ellen","family":"Gunning","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duy","family":"Nguyen","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Nicholson","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Stoate","sequence":"additional","affiliation":[{"name":"AGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"2025122722264171900_R1"},{"key":"2025122722264171900_R2"},{"key":"2025122722264171900_R3"},{"key":"2025122722264171900_R4","doi-asserted-by":"publisher","first-page":"S461","DOI":"10.1071\/AJ21124","article-title":"The Northwest Offshore Otway Basin Well Folio.","volume":"62","author":"Nguyen","year":"2022","journal-title":"The APPEA Journal"},{"issue":"S1","key":"2025122722264171900_R5","doi-asserted-by":"publisher","first-page":"S467","DOI":"10.1071\/AJ21072","article-title":"Stratigraphic framework and structural architecture of the Upper Cretaceous in the Deep-water Otway Basin \u2013 implications for frontier hydrocarbon prospectivity.","volume":"62","author":"Nicholson","year":"2022","journal-title":"The APPEA Journal"}],"container-title":["The APPEA Journal"],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/63\/2\/S215\/472822\/aj22090.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/63\/2\/S215\/472822\/aj22090.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T03:26:46Z","timestamp":1766892406000},"score":7.618301,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/ep\/article\/63\/2\/S215\/77470\/Cretaceous-depositional-environment-interpretation"}},"issued":{"date-parts":[[2023,5,11]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,5,11]]}},"URL":"https:\/\/doi.org\/10.1071\/aj22090","ISSN":["1326-4966","2206-8996"],"issn-type":[{"type":"print","value":"1326-4966"},{"type":"electronic","value":"2206-8996"}],"published":{"date-parts":[[2023,5,11]]}},{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:11:31Z","timestamp":1759972291363,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2024,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>As an extension of the central nervous system (CNS), the retina shares many similarities with the brain and can manifest signs of various neurological diseases, including Alzheimer\u2019s disease (AD). This study investigates the spectral features of the retina to develop a classification model for the differentiation of individuals with elevated brain amyloid levels.<\/jats:p><\/jats:sec>Method<\/jats:title>Participants (n=66) with varying brain A\u03b2 levels, as determined by brain imaging, were non\u2010invasively imaged using a hyperspectral retinal camera at wavelengths of 450 to 905 nm. Multiple image features from the central view and superior view of retinas were selected and analysed to identify their variability among individuals with different brain amyloid loads. A machine learning classification model was trained to differentiate individuals with varying amyloid levels using the spectra of extracted retinal features.<\/jats:p><\/jats:sec>Result<\/jats:title>The retinal reflectance spectra between the wavelengths of 405\u2013585 nm exhibited a significant difference between the individuals with raised brain amyloid levels. The performance of the spectral classification model was dependent on retinal region and showed 0.778\u20130.857 accuracy, 0.718\u20130.909 sensitivity, 0.778\u20130.912 specificity, and 0.758\u20130.878 AUC.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study highlights the spectral variation of retinal features associated with brain amyloid load. It also demonstrates the feasibility of the retinal hyperspectral imaging technique as a potential inexpensive screening method to identify individuals in the preclinical phases of AD and as a complementary or alternative to brain imaging.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.090889","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:48:11Z","timestamp":1736405291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Retinal and brain imaging modalities for AD detection and monitoring"],"prefix":"10.1002","volume":"20","author":[{"given":"Ralph N","family":"Martins","sequence":"first","affiliation":[{"name":"Australian Alzheimer's Research Foundation, Perth, Western Australia Australia"},{"name":"Macquarie University, Sydney, NSW Australia"},{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Lions Alzheimer's Foundation, Perth, Western Australia 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The X\u2010ray photo electron spectroscopy (XPS) characterisation shows a substantial improvement in film stability in buffer solution when depositing at temperatures above 50\u00b0C. Principal component analysis of the time\u2010of\u2010flight\u2013secondary ion mass spectrometry data shows excellent correlation with the XPS results, providing insights into the degree of crosslinking in the plasma coatings as a function of substrate temperature. Atomic force microscopy images showed the topography of OX plasma polymer coatings deposited at 80\u00b0C and 120\u00b0C to be smoother with lower surface roughness values compared to those produced at 50\u00b0C. Finally, an 80% reduction in the adhesion of Staphylococcus epidermidis<\/jats:italic> is achieved at the centre of the plasma coatings deposited at 120\u00b0C.<\/jats:p>","DOI":"10.1002\/ppap.201900104","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T11:28:56Z","timestamp":1564658936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Deposition of 2\u2010oxazoline\u2010based plasma polymer coatings using atmospheric pressure helium plasma jet"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1711-8032","authenticated-orcid":false,"given":"Sameer A.","family":"Al\u2010Bataineh","sequence":"first","affiliation":[{"name":"Future Industries Institute University of South Australia Adelaide South Australia 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This study explores how a self-guided, neurodiversity-affirming resource\u2014the \u201cWelcome Pack\u201d\u2014supports newly diagnosed autistic adults in navigating their evolving identity. Using a qualitative approach, we recruited 11 autistic adults without intellectual disability in Australia who had received a diagnosis within the past 6\u2009months. Participants engaged with the \u201cWelcome Pack\u201d over a 2-month period before taking part in semi-structured interviews. Reflexive thematic analysis generated four key themes: (1) a sense of belonging through community and representation, as participants found validation in shared narratives; (2) the \u201cWelcome Pack\u201d as one of many tools supporting their self-understanding; (3) emotional reflections, including both relief and grief over years of masking; and (4) challenges in self-advocacy and educating others. While participants described the \u201cWelcome Pack\u201d as an important and validating resource, they also highlighted the need for additional structured peer support and practical guidance. These findings underscore the value of integrating self-guided resources within broader post-diagnostic ecosystems, ensuring that newly diagnosed autistic adults receive timely, accessible, and neurodiversity-affirming support as they navigate their identity.<\/jats:p>\n \n Lay Abstract<\/jats:title>\n <\/jats:sec>","DOI":"10.1177\/13623613251335070","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T07:38:34Z","timestamp":1745566714000},"page":"2072-2083","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["\u201cI\u2019m not feeling alone in my experiences\u201d: How newly diagnosed autistic adults engage with a neurodiversity-affirming \u201cWelcome Pack\u201d"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-674X","authenticated-orcid":false,"given":"Chris","family":"Edwards","sequence":"first","affiliation":[{"name":"Autism Spectrum Australia (Aspect), Australia"},{"name":"Griffith University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6647-9814","authenticated-orcid":false,"given":"Abigail MA","family":"Love","sequence":"additional","affiliation":[{"name":"Autism Spectrum Australia (Aspect), Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-0495","authenticated-orcid":false,"given":"Ru Ying","family":"Cai","sequence":"additional","affiliation":[{"name":"Autism Spectrum Australia (Aspect), Australia"},{"name":"The University of Melbourne, Australia"},{"name":"La Trobe University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Heyworth","sequence":"additional","affiliation":[{"name":"Reframing Autism, Australia"},{"name":"Macquarie University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Johnston","sequence":"additional","affiliation":[{"name":"Griffith University, Australia"},{"name":"Reframing Autism, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Aldridge","sequence":"additional","affiliation":[{"name":"Autism Spectrum Australia (Aspect), Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-5164","authenticated-orcid":false,"given":"Vicki","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Autism Spectrum Australia (Aspect), Australia"},{"name":"The University of Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"crossref","unstructured":"Ardeleanu K. 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Their grouping ability as the straightness varied was assessed using a compound bow and shooting machine. The research showed that archers would benefit from selecting arrows with the highest straightness grades (as might be expected). In addition, nock selection was determined to significantly impact group size. The fletches needed to be set at an angle to the longitudinal axis of the arrow shaft in order to have the arrows spin while in free flight, as that further reduced the group size. <\/jats:p>","DOI":"10.1177\/1754337117736705","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T07:10:01Z","timestamp":1508137801000},"page":"236-241","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of arrow shaft straightness on arrow grouping"],"prefix":"10.1177","volume":"232","author":[{"given":"James L","family":"Park","sequence":"first","affiliation":[{"name":"Archery Australia, Panania, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J","family":"Aitchison","sequence":"additional","affiliation":[{"name":"Archery Australia, Panania, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam J","family":"Bielby","sequence":"additional","affiliation":[{"name":"Archery Australia, Panania, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Bleakley","sequence":"additional","affiliation":[{"name":"Archery Australia, Panania, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trent P","family":"Carberry","sequence":"additional","affiliation":[{"name":"Archery Australia, Panania, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M","family":"Ellis","sequence":"additional","affiliation":[{"name":"Archery Canada, Ottawa, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard D","family":"Kerner","sequence":"additional","affiliation":[{"name":"NFAA, Yankton, SD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Archery Australia, Panania, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danie","family":"Oosthuizen","sequence":"additional","affiliation":[{"name":"Archery Australia, Panania, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott B","family":"Pankhurst","sequence":"additional","affiliation":[{"name":"Archery Australia, Panania, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Psarakis","sequence":"additional","affiliation":[{"name":"Hellenic Archery Federation, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,10,16]]},"reference":[{"key":"bibr1-1754337117736705","doi-asserted-by":"publisher","DOI":"10.1177\/1754337111407124"},{"key":"bibr2-1754337117736705","unstructured":"American National Standard F 1889-05:2005. Standard guide for straightness measurement of arrow shafts (ASTM International)."},{"key":"bibr3-1754337117736705","unstructured":"Easton Technical Products. Target Archery catalogue, 2016."},{"key":"bibr4-1754337117736705","unstructured":"World Archery. Rules, https:\/\/worldarchery.org\/Rules (accessed 29 December 2016)."},{"key":"bibr5-1754337117736705","unstructured":"Arizona Archery Enterprises. Arrow straightener, https:\/\/arizonaarchery.com\/products (accessed 29 December 2016)."},{"key":"bibr6-1754337117736705","unstructured":"Spot Hogg. Shooting machine, http:\/\/spot-hogg.com\/accessories (accessed 29 December 2016)."},{"key":"bibr7-1754337117736705","first-page":"8","volume":"225","author":"Park JL","year":"2010","journal-title":"Proc IMechE, Part P: J Sports Engineering and Technology"}],"container-title":["Proceedings of the Institution of Mechanical Engineers, Part P: Journal of Sports Engineering and Technology"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1754337117736705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1754337117736705","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1754337117736705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T05:57:31Z","timestamp":1740808651000},"score":7.61796,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1754337117736705"}},"issued":{"date-parts":[[2017,10,16]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1177\/1754337117736705"],"URL":"https:\/\/doi.org\/10.1177\/1754337117736705","ISSN":["1754-3371","1754-338X"],"issn-type":[{"type":"print","value":"1754-3371"},{"type":"electronic","value":"1754-338X"}],"published":{"date-parts":[[2017,10,16]]}},{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:21:38Z","timestamp":1785522098439,"version":"3.56.0"},"reference-count":0,"publisher":"Wiley","issue":"S7","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2022,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Cognitive reserve is the term used to describe the apparent ability of one\u2019s cognitive processes or neural networks to adapt in response to neuropathology and brain injury. This protective ability is proposed to account for individual differences in age\u2010associated cognitive decline and Alzheimer\u2019s disease (AD) risk, where higher levels of cognitive reserve are associated with more preserved cognitive functioning and delayed onset of AD dementia. Women have a higher prevalence of AD than men, and account for two\u2010thirds of AD diagnoses. Sex differences in the protective ability of cognitive reserve may account for differences in Alzheimer\u2019s disease prevalence between men and women, but few studies have explored this possibility. This study evaluates sex as a moderator of the relationship between cognitive reserve and brain volume effects on executive function.<\/jats:p><\/jats:sec>Method<\/jats:title>The study used archival data from 997 older adult participants in the Australian Imaging, Biomarkers, and Lifestyle(AIBL) Flagship Study of Ageing (see Table 1 for descriptives). Structural equation modelling was used to estimate a proxy for cognitive reserve and to run the analytical model. Cognitive reserve was defined as the variance in episodic memory not explained by demographics (e.g., education) and brain integrity (i.e., the residual reserve index; Reed et al., 2010). Executive functioning intercept and slope \u2013 derived from up to 7 study visits (18\u2010month follow\u2010up intervals) \u2013 were regressed onto the main and interaction effects of the residual reserve index, brain integrity (i.e., the combination of grey matter, hippocampal, and white matter hyperintensity volumes), and sex, plus covariates (e.g., number of apolipoprotein alleles; age).<\/jats:p><\/jats:sec>Result<\/jats:title>A significant three\u2010way interaction was observed between cognitive reserve, brain integrity, and sex; Women benefitted more than men from the protective effects of cognitive reserve at comparably low levels of brain integrity. Further analyses also showed that women, on average, have higher levels of cognitive reserve as reflected by the residual reserve index.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Sex differences in cognitive reserve highlight a potential sex\u2010related mechanism by which cognitive reserve confers protection against cognitive decline in the face of low brain integrity. These findings further our understanding of potential factors that maximise the protective effect of cognitive reserve.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.064397","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T10:47:23Z","timestamp":1671533243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sex differences in the protective effects of cognitive reserve"],"prefix":"10.1002","volume":"18","author":[{"given":"Cheyenne K","family":"Chooi","sequence":"first","affiliation":[{"name":"University of Western Australia, Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon E","family":"Gavett","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth Western Australia 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Dementia"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.064397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.064397","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.064397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T14:39:10Z","timestamp":1759934350000},"score":7.617937,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.064397"}},"issued":{"date-parts":[[2022,12]]},"references-count":0,"journal-issue":{"issue":"S7","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/alz.064397"],"URL":"https:\/\/doi.org\/10.1002\/alz.064397","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"2022-12-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication 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Broda","sequence":"first","affiliation":[{"name":"Federation University,Ballarat,Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiwo","family":"Oseni","sequence":"additional","affiliation":[{"name":"Federation University,Ballarat,Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Stranieri","sequence":"additional","affiliation":[{"name":"Federation University,Ballarat,Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Marino","sequence":"additional","affiliation":[{"name":"University of Melbourne,Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodie","family":"Robinson","sequence":"additional","affiliation":[{"name":"Ballarat Health Services,Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Yates","sequence":"additional","affiliation":[{"name":"Ballarat Health Services,Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"320","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"key":"e_1_3_2_1_1_1","unstructured":"Royal Commission into Aged Care Quality and Safety: Interim Report. 2019 [cited 2020 February 9]; Available from: https:\/\/agedcare.royalcommission.gov.au\/publications\/Pages\/interim-report.aspx. Royal Commission into Aged Care Quality and Safety: Interim Report. 2019 [cited 2020 February 9]; Available from: https:\/\/agedcare.royalcommission.gov.au\/publications\/Pages\/interim-report.aspx."},{"key":"e_1_3_2_1_2_1","volume-title":"Healthy Mouths","author":"COAG","year":"2015","unstructured":"COAG , Healthy Mouths , Healthy Lives : Australia's National Oral Health Plan 2015 \u20132024. 2015, South Australian Dental Service: Adelaide, South Australia . COAG, Healthy Mouths, Healthy Lives: Australia's National Oral Health Plan 2015\u20132024. 2015, South Australian Dental Service: Adelaide, South Australia."},{"key":"e_1_3_2_1_3_1","volume-title":"An integrated oral health program for rural residential aged care facilities: a mixed methods comparative study. BMC health services research","author":"Tynan A.","year":"2018","unstructured":"Tynan , A. , L. Deeth , and D. McKenzie , An integrated oral health program for rural residential aged care facilities: a mixed methods comparative study. BMC health services research , 2018 . 18(1): p. 515. Tynan, A., L. Deeth, and D. McKenzie, An integrated oral health program for rural residential aged care facilities: a mixed methods comparative study. BMC health services research, 2018. 18(1): p. 515."},{"key":"e_1_3_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2016.04.002"},{"key":"e_1_3_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-08973-7_10"},{"key":"e_1_3_2_1_6_1","volume-title":"Preventive actions for enhancing oral health. Clinics in geriatric medicine","author":"Niessen L.C.","year":"1992","unstructured":"Niessen , L.C. and C.W. Douglass , Preventive actions for enhancing oral health. Clinics in geriatric medicine , 1992 . 8(1): p. 201-214. Niessen, L.C. and C.W. Douglass, Preventive actions for enhancing oral health. Clinics in geriatric medicine, 1992. 8(1): p. 201-214."},{"key":"e_1_3_2_1_7_1","first-page":"29","volume-title":"Geriatric Nursing","author":"Whitmyer C.C.","year":"1998","unstructured":"Whitmyer , C.C. , , Clinical evaluation of the efficacy and safety of an ultrasonic toothbrush system in an elderly patient population . Geriatric Nursing , 1998 . 19(1): p. 29 - 33 . Whitmyer, C.C., , Clinical evaluation of the efficacy and safety of an ultrasonic toothbrush system in an elderly patient population. Geriatric Nursing, 1998. 19(1): p. 29-33."},{"key":"e_1_3_2_1_8_1","first-page":"108","author":"Grossman E.","year":"1995","unstructured":"Grossman , E. , W. Dembling , and H. Proskin , A comparative clinical investigation of the safety and efficacy of an oscillating\/rotating electric toothbrush and a sonic toothbrush. The Journal of clinical dentistry , 1995 . 6(1): p. 108 . Grossman, E., W. Dembling, and H. Proskin, A comparative clinical investigation of the safety and efficacy of an oscillating\/rotating electric toothbrush and a sonic toothbrush. The Journal of clinical dentistry, 1995. 6(1): p. 108.","journal-title":"The Journal of clinical dentistry"},{"key":"e_1_3_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110675"},{"key":"e_1_3_2_1_10_1","volume-title":"Proceedings of the SIGCHI conference on human factors in computing systems.","author":"Chang Y.","year":"2008","unstructured":"Chang , Y. - C. , Playful toothbrush : ubicomp technology for teaching tooth brushing to kindergarten children . in Proceedings of the SIGCHI conference on human factors in computing systems. 2008 . ACM. Chang, Y.-C., Playful toothbrush: ubicomp technology for teaching tooth brushing to kindergarten children. in Proceedings of the SIGCHI conference on human factors in computing systems. 2008. ACM."},{"key":"e_1_3_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cviu.2016.03.009"},{"key":"e_1_3_2_1_12_1","volume-title":"Journal of the AIS","author":"Wu P.F.","year":"2011","unstructured":"Wu , P.F. , A mixed methods approach to technology acceptance research . Journal of the AIS , 2011 . Wu, P.F., A mixed methods approach to technology acceptance research. Journal of the AIS, 2011."},{"key":"e_1_3_2_1_13_1","first-page":"e1000360","author":"Greenhalgh T.","year":"2010","unstructured":"Greenhalgh , T. and J. Russell , Why do evaluations of eHealth programs fail? An alternative set of guiding principles. PLoS Med , 2010 . 7(11): p. e1000360 . Greenhalgh, T. and J. Russell, Why do evaluations of eHealth programs fail? An alternative set of guiding principles. PLoS Med, 2010. 7(11): p. e1000360.","journal-title":"An alternative set of guiding principles. PLoS Med"},{"key":"e_1_3_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/imms.1993.1022"},{"key":"e_1_3_2_1_15_1","volume-title":"A three cycle view of design science research. Scandinavian journal of information systems","author":"Hevner A.R.","year":"2007","unstructured":"Hevner , A.R. , A three cycle view of design science research. Scandinavian journal of information systems , 2007 . 19(2): p. 4. Hevner, A.R., A three cycle view of design science research. Scandinavian journal of information systems, 2007. 19(2): p. 4."},{"key":"e_1_3_2_1_16_1","volume-title":"Using actors to develop technologies for older adults with dementia: A pilot study","author":"Boger J.","year":"2010","unstructured":"Boger , J. , , Using actors to develop technologies for older adults with dementia: A pilot study . 2010 . Boger, J., , Using actors to develop technologies for older adults with dementia: A pilot study. 2010."},{"key":"e_1_3_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2016.09.004"},{"key":"e_1_3_2_1_18_1","volume-title":"Cost-analysis of teledentistry in residential aged care facilities. Journal of telemedicine and telecare","author":"Mari\u00f1o R.","year":"2016","unstructured":"Mari\u00f1o , R. , , Cost-analysis of teledentistry in residential aged care facilities. Journal of telemedicine and telecare , 2016 . 22(6): p. 326-332. Mari\u00f1o, R., , Cost-analysis of teledentistry in residential aged care facilities. Journal of telemedicine and telecare, 2016. 22(6): p. 326-332."},{"key":"e_1_3_2_1_19_1","volume-title":"International journal on advances in life sciences","author":"Mari\u00f1o R.","year":"2014","unstructured":"Mari\u00f1o , R. , , Teleconsultation\/telediagnosis using teledentistry technology : a pilot feasibility study . International journal on advances in life sciences , 2014 . 6(3 & 4): p. 291-299. Mari\u00f1o, R., , Teleconsultation\/telediagnosis using teledentistry technology: a pilot feasibility study. International journal on advances in life sciences, 2014. 6(3 & 4): p. 291-299."}],"event":{"name":"ICMHI 2021: 2021 5th International Conference on Medical and Health Informatics","acronym":"ICMHI 2021","location":"Kyoto Japan"},"container-title":["2021 5th International Conference on Medical and Health Informatics"],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3472813.3473186","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3472813.3473186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T20:11:56Z","timestamp":1750191116000},"score":7.6171694,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3472813.3473186"}},"issued":{"date-parts":[[2021,5,14]]},"references-count":19,"alternative-id":["10.1145\/3472813.3473186","10.1145\/3472813"],"URL":"https:\/\/doi.org\/10.1145\/3472813.3473186","published":{"date-parts":[[2021,5,14]]}},{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:22:07Z","timestamp":1783689727560,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2026,7,1]]},"abstract":"Abstract<\/jats:title>\n \n Study question<\/jats:title>\n Can conventional in vitro fertilisation (IVF) be an alternative to intracytoplasmic sperm injection (ICSI) in preimplantation genetic testing for aneuploidy (PGT-A) without male factor infertility?<\/jats:p>\n <\/jats:sec>\n \n Summary answer<\/jats:title>\n These findings support the use of conventional IVF as a valid fertilization strategy in PGT-A cycles without male factor infertility.<\/jats:p>\n <\/jats:sec>\n \n What is known already<\/jats:title>\n Intracytoplasmic sperm injection (ICSI) is widely adopted in PGT-A cycles to reduce the theoretical risk of paternal DNA contamination, even in couples without male-factor infertility. However, conventional IVF allows physiological sperm selection and has demonstrated comparable effectiveness to ICSI in non-male factor patients, with similar embryo development, euploidy rates, and clinical outcomes. Recent studies in PGT settings suggest comparable chromosomal and reproductive outcomes between IVF and ICSI, but evidence remains limited and varied, and the clinical relevance of the insemination method in PGT-A cycles is still debated.<\/jats:p>\n <\/jats:sec>\n \n Study design, size, duration<\/jats:title>\n This retrospective cohort study included all non-male factor PGT-A freeze-all cycles performed between 1 January 2022 and 31 December 2024 in one centre. Baseline characteristics were broadly comparable. A total of 3,674 embryos from 1,241 cycles were analysed to compare euploidy rates between IVF and ICSI. Additionally, 1,018 frozen embryo transfers (FETs) (771 IVF and 247 ICSI) within the same period were evaluated for clinical outcomes. Donor cycles and imported embryos were excluded.<\/jats:p>\n <\/jats:sec>\n \n Participants\/materials, setting, methods<\/jats:title>\n Multivariable logistic regression models were used to assess differences between IVF and ICSI in terms of embryo euploidy, clinical pregnancy (CP), and live birth rates (LBR). Separate models were constructed for each outcome, with insemination method as the primary exposure. Results were reported as odds ratios with 95% confidence intervals. Robust standard errors were estimated by clustering at the treatment cycle level to account for intra-cycle correlation. Statistical significance was set at p\u2009&lt;\u20090.05.<\/jats:p>\n <\/jats:sec>\n \n Main results and the role of chance<\/jats:title>\n After adjustment for potential confounders, including cycle number, maternal age, body mass index (BMI), embryo quality, embryo stage, day of embryo culture, number of oocytes with two pronuclei (2PN), sperm concentration, and sperm motility, no significant differences were observed in euploidy, clinical pregnancy (CP), or live birth rate (LBR) between ICSI and IVF in PGT-A cycles. Euploidy rates did not differ significantly between the two groups (ICSI:519\/897 [57.9%] vs IVF:1,620\/2,777 [58.3%]; OR 0.94, 95% CI 0.78\u20131.13; p\u2009=\u20090.5). Clinical pregnancy, defined as ultrasound visualization of a gestational sac, also did not differ between groups (ICSI:126\/247 [51.0%] vs IVF:419\/771 [54.3%]; OR 0.91, 95% CI 0.70\u20131.18; p\u2009=\u20090.5). Similarly, live birth rates were comparable between ICSI and IVF (ICSI:103\/247 [41.7%] vs IVF:356\/771 [44.9%]; OR 0.93, 95% CI 0.71\u20131.23; p\u2009=\u20090.6)<\/jats:p>\n <\/jats:sec>\n \n Limitations, reasons for caution<\/jats:title>\n This was a retrospective, non-randomised single-centre study, therefore residual confounding and selection bias cannot be excluded. Differences in laboratory protocols or clinical management over time may have influenced outcomes. The smaller ICSI FET sample may limit power to detect small differences.<\/jats:p>\n <\/jats:sec>\n \n Wider implications of the findings<\/jats:title>\n In non-male factor PGT-A freeze-all cycles, ICSI does not confer advantages over conventional IVF in terms of euploidy, clinical pregnancy, or live birth. These results support an IVF-first approach and may help reduce unnecessary ICSI use, improving cost-effectiveness and optimising embryology laboratory workload without compromising outcomes.<\/jats:p>\n <\/jats:sec>\n \n Trial registration number<\/jats:title>\n No<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/humrep\/deag083.539","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T09:42:18Z","timestamp":1783503738000},"source":"Crossref","is-referenced-by-count":0,"title":["L26\/P-203 Intracytoplasmic sperm injection (ICSI) versus conventional in vitro fertilisation (IVF) in non-male factor preimplantation genetic testing for aneuploidy (PGT-A) cycles: a retrospective analysis"],"prefix":"10.1093","volume":"41","author":[{"given":"C.","family":"Vitiello","sequence":"first","affiliation":[{"name":"IVF Australia, IVF Australia , Sydney,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.K.","family":"Hua","sequence":"additional","affiliation":[{"name":"IVF Australia, IVF Australia , Sydney,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Murray","sequence":"additional","affiliation":[{"name":"IVF Australia, IVF Australia , Sydney,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lahoud","sequence":"additional","affiliation":[{"name":"IVF Australia, IVF Australia , Sydney,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Hesketh","sequence":"additional","affiliation":[{"name":"IVF Australia, IVF Australia , Sydney,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,8]]},"container-title":["Human Reproduction"],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/41\/Supplement_1\/deag083.539\/68715074\/deag083.539.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/41\/Supplement_1\/deag083.539\/68715074\/deag083.539.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:45:30Z","timestamp":1783687530000},"score":7.616601,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/doi\/10.1093\/humrep\/deag083.539\/8727872"}},"issued":{"date-parts":[[2026,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2026,7,8]]},"published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deag083.539","ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,7,1]]},"article-number":"deag083.539"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:41:53Z","timestamp":1753890113845,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: The BANDIT trial investigated the efficacy of the JAK inhibitor baricitinib in new-onset type 1 diabetes (T1D) by measuring clinical endpoints and immunological parameters. Along with preserving C-peptide, we observed changes in immune cells during baricitinib treatment. The objective of this study was to further characterise those changes and elucidate specific molecular and cellular pathways affected by baricitinib.<\/jats:p>\n Methods: PBMCs were isolated at baseline and at 24 weeks of baricitinib (n = 30) or placebo (n = 18) treatment. For FACS, cell-specific antibodies were used to quantify NK subsets. For CITE-seq data, singlets were processed using Seurat, and differentially expressed gene (DEG) analysis was performed using edgeR and Limma.<\/jats:p>\n Results: The frequency of circulating cytotoxic CD56dim and immunomodulatory CD56bright NK cells decreased at 24 weeks of baricitinib. We identified 305 DEG in the CD56dim NK cells from baricitinib-treated patients at week 24 compared to baseline, and 17 DEG were identified at week 24 between baricitinib and placebo treatment groups. The JAK-STAT pathway genes STAT4, SOCS2 and PTPRC, along with other genes involved in differentiation and regulation, were downregulated by baricitinib; whereas genes related to migration were upregulated. In CD56bright NK cells, only GOLGA8A was downregulated by baricitinib compared to placebo at week 24.<\/jats:p>\n Conclusion: This study is a critical step in defining immunological effects caused by baricitinib in T1D. Notably, the reduction of CD56dim NK cells was associated with changes in the expression of JAK-STAT genes, essential for proliferation and activation. These effects are likely due to baricitinib blockade of common \u03b3 chain cytokine signalling. In particular, blockade of IL-2\/IL-12\/IL-15 signalling would inhibit NK-cell proliferation. This study highlights key pathways and cells affected by baricitinib that may further explain its beneficial effect for treating T1D.<\/jats:p>\n \n Disclosure<\/jats:title>\n L. Sanz Villanueva: None. C. Chiu: None. L. Mackin: None. T. Catterall: None. M. Waibel: None. I. Gallego Romero: None. B. Krishnamurthy: None. T. Brodnicki: None. T. Kay: Advisory Panel; Sanofi, SAB Biotherapeutics, Inc.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-30-or","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:56:19Z","timestamp":1749794179000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["30-OR: Baricitinib-Associated Changes in Single-Cell Gene Expression in NK Cells in the BANDIT Clinical Trial"],"prefix":"10.2337","volume":"74","author":[{"given":"LAURA","family":"SANZ VILLANUEVA","sequence":"first","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRIS","family":"CHIU","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEANNE","family":"MACKIN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TARA","family":"CATTERALL","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAELA","family":"WAIBEL","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IRENE","family":"GALLEGO ROMERO","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BALASUBRAMANIAN","family":"KRISHNAMURTHY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"THOMAS","family":"BRODNICKI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"THOMAS","family":"KAY","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/30-OR\/159447\/30-OR-Baricitinib-Associated-Changes-in-Single","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/30-OR\/159447\/30-OR-Baricitinib-Associated-Changes-in-Single","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T16:27:59Z","timestamp":1750436879000},"score":7.6165786,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/30-OR\/159447\/30-OR-Baricitinib-Associated-Changes-in-Single"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-30-or","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"30-OR"},{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:49:03Z","timestamp":1761061743390,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2023,6]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>This study assessed replacing traditional protocol CT\u2010arterial chest and venous abdomen and pelvis, with a single\u2010pass, single\u2010bolus, venous phase CT chest, abdomen and pelvis (CAP) protocol in general oncology outpatients at a single centre.<\/jats:p><\/jats:sec>Methods<\/jats:title>A traditional protocol is an arterial phase chest followed by venous phase abdomen and pelvis. A venous CAP (vCAP) protocol is a single acquisition 60\u00a0s after contrast injection, with optional arterial phase upper abdomen based on the primary tumour. Consecutive eligible patients were assessed, using each patient's prior study as a comparator. Attenuation for various structures, lesion conspicuity and dose were compared. Subset analysis of dual\u2010energy (DE) CT scans in the vCAP protocol performed for lesion conspicuity on 50\u2009keV virtual monoenergetic (VME) images.<\/jats:p><\/jats:sec>Results<\/jats:title>One hundred and eleven patients were assessed with both protocols. Forty\u2010six patients had their vCAP scans using DECT. The vCAP protocol had no significant difference in the attenuation of abdominal structures, with reduced attenuation of mediastinal structures. There was a significant improvement in the visibility of pleural lesions (p<\/jats:italic>\u00a0<\u20090.001), a trend for improved mediastinal nodes assessment, and no significant difference for abdominal lesions. A significant increase in liver lesion conspicuity on 50\u2009keV VME reconstructions was noted for both readers (p<\/jats:italic>\u00a0<\u20090.001). There were significant dose reductions with the vCAP protocol.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>A single\u2010pass vCAP protocol offered an improved thoracic assessment with no loss of abdominal diagnostic confidence and significant dose reductions compared to traditional protocol. Improved liver lesion conspicuity on 50\u2009keV VME images across a range of cancers is promising.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13490","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T10:14:19Z","timestamp":1669025659000},"page":"349-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of a single\u2010pass venous phase CT<\/scp> chest, abdomen and pelvis and dual\u2010energy CT<\/scp> in general oncology outpatients"],"prefix":"10.1111","volume":"67","author":[{"given":"Huey Ming","family":"Seah","sequence":"first","affiliation":[{"name":"South Australia Medical Imaging Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hau Cher","family":"Choi","sequence":"additional","affiliation":[{"name":"South Australia Medical Imaging Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Bajic","sequence":"additional","affiliation":[{"name":"South Australia Medical Imaging Adelaide South Australia Australia"},{"name":"Jones Radiology Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Oakden\u2010Rayner","sequence":"additional","affiliation":[{"name":"South Australia Medical Imaging Adelaide South Australia Australia"},{"name":"Jones Radiology Adelaide South Australia Australia"},{"name":"Australian Institute for Machine Learning University of Adelaide Adelaide South Australia Australia"},{"name":"The University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9794-5507","authenticated-orcid":false,"given":"Kirsten L","family":"Gormly","sequence":"additional","affiliation":[{"name":"Jones Radiology Adelaide South Australia Australia"},{"name":"The University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-016-0093-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.10354"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.343135041"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.17.19185"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.13350"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/55980445"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2016.11.010"},{"key":"e_1_2_7_9_1","first-page":"3041","article-title":"Single\u2010phase whole\u2010body 64\u2010MDCT split\u2010bolus protocol for pediatric oncology: diagnostic efficacy and dose radiation","volume":"35","author":"Scialpi M","year":"2015","journal-title":"Anticancer Res"},{"key":"e_1_2_7_10_1","unstructured":"LekgabeE TranN CheungWet\u00a0al.Single\u2010pass CT chest\/abdomen\/pelvis for oncology patients: effect on radiation dose and image quality. Poster session presented at: The European Congress of Radiology; Vienna Austria 2015."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2015.05.014"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10140-018-1591-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3702"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000257"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-016-0073-5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.9074"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1961.10482090"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-60349-5_4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2016.09.003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.07.86"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2020.06.002"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-019-0235-3"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20120224"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.1104"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3181e33189"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3181dfda78"},{"key":"e_1_2_7_27_1","first-page":"782","article-title":"Contribution of DECT in detecting serosal invasion of gastric cancer","volume":"49","author":"Kupeli A","year":"2019","journal-title":"Turk J Med Sci"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.9207"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2018.06.017"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.562945"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2020.03.006"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.13490","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1754-9485.13490","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.13490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T06:13:04Z","timestamp":1692339184000},"score":7.616558,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.13490"}},"issued":{"date-parts":[[2022,11,21]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/1754-9485.13490"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.13490","archive":["Portico"],"ISSN":["1754-9477","1754-9485"],"issn-type":[{"type":"print","value":"1754-9477"},{"type":"electronic","value":"1754-9485"}],"published":{"date-parts":[[2022,11,21]]},"assertion":[{"value":"2022-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:25:46Z","timestamp":1787246746255,"version":"build-2736575974"},"reference-count":0,"publisher":"Society of Exploration Geophysicists","content-domain":{"domain":[],"crossmark-restriction":false},"abstract":"The Browse Basin is a major Paleozoic to Cenozoic depocentre on Australia\u2019s Northwest Shelf that contains extensive petroleum reserves. Some of the gas accumulations have naturally elevated levels of CO2 and future development of these gas fields may require sequestration options. A regional sequence stratigraphic analysis and geochemical study, using newly acquired geophysical data (from marine seepage and aeromagnetic surveys) and sediment samples, were undertaken to provide an updated basin framework and a better understanding of the potential of Cretaceous supersequences for both CO2 storage and hydrocarbons. Updated biostratigraphy, well correlations, seismic, paleogeography interpretation and play fairway mapping were completed for seven supersequences, from the Berriasian to Maastrichtian. This analysis shows that entrenched fluvial systems flowing from the Kimberley Paleoproterozoic Basin on the inner-shelf formed a complex network of sedimentary inputs that operated throughout the Cretaceous. These fluvial systems fed numerous large submarine fan complexes of variable reservoir quality that are potentially isolated from the deltaic systems. These were deposited with N-NW progradation in the central and northern depocentres during sea level falls in the Berriasian, Valanginian, Barremian, Campanian and Maastrichtian. A risk assessment was carried out to better understand the suitability of these fans for CO2 storage, including reservoir quality characterisation using well log analysis and key containment constraints. The constraints investigated include fault reactivation, connectivity between sand bodies, hydrocarbon presence and indications of present-day or palaeo-seepage. Geochemical analysis and Grains with Oil Inclusions (GOI) techniques were used to assess the seal integrity. Contemporary stress field indicators suggest that the basin is most likely in a strike-slip faulting regime, with the main compression direction oriented E-W. Seal integrity modelling predicts that faults trending WSW\u2013ENE and WNW\u2013ESE are most prone to reactivation in response to CO2 injection. Common risk element maps allow characterisation of reservoir and seal pairs away from these key containment risks and prioritisation of areas that are located within Upper Cretaceous submarine fans. This study provides a framework for further work which will help determine the suitability of potential CO2 storage sites, which are not in direct conflict with hydrocarbon prospectivity.<\/jats:p>","DOI":"10.1190\/ice2015-2210789","type":"proceedings-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T14:10:38Z","timestamp":1458223838000},"page":"270-270","source":"Crossref","is-referenced-by-count":0,"title":["Cretaceous Stratigraphic Play Fairways and Risk Assessment in the Browse Basin: Implications for CO2 Storage"],"prefix":"10.1190","volume":"1","author":[{"given":"Nadege","family":"Rollet*","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve T.","family":"Abbott","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"Lech","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Caust","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowan","family":"Romeyn","sequence":"additional","affiliation":[{"name":"1Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Romine","sequence":"additional","affiliation":[{"name":"2FROGTECH, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Blevin","sequence":"additional","affiliation":[{"name":"2FROGTECH, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Khider","sequence":"additional","affiliation":[{"name":"3Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Nicholson","sequence":"additional","affiliation":[{"name":"3Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Grosjean","sequence":"additional","affiliation":[{"name":"3Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"Kempton","sequence":"additional","affiliation":[{"name":"4CSIRO Energy Flagship, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Tenthorey","sequence":"additional","affiliation":[{"name":"5Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Totterdell","sequence":"additional","affiliation":[{"name":"5Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Nguyen","sequence":"additional","affiliation":[{"name":"5Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuqi","family":"Wang","sequence":"additional","affiliation":[{"name":"5Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Hackney","sequence":"additional","affiliation":[{"name":"5Geoscience Australia, Canberra, Australian Capital Territory, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"186","published-online":{"date-parts":[[2015,9,16]]},"event":{"name":"International Conference and Exhibition, Melbourne, Australia 13-16 September 2015","location":"Melbourne, Australia","acronym":"icemelbourne2015","start":{"date-parts":[[2015,9,13]]},"end":{"date-parts":[[2015,9,16]]}},"container-title":["Global Meeting Abstracts","International Conference and Exhibition, Melbourne, Australia 13-16 September 2015"],"link":[{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/270\/713950","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/270\/713950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:36:28Z","timestamp":1787243788000},"score":7.6165314,"resource":{"primary":{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/270\/713950"}},"issued":{"date-parts":[[2015,9,16]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1190\/ice2015-2210789","ISSN":["2159-6832"],"issn-type":[{"value":"2159-6832","type":"electronic"}],"published":{"date-parts":[[2015,9,16]]}},{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:39:04Z","timestamp":1787236744988,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dust Diseases Board of New South Wales (Australia)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Abstract<\/jats:title>\n \n Background and objective<\/jats:title>\n \n Many of the pathological consequences in the lung following inhalation of asbestos fibres arise as a consequence of persistent oxidative stress and inflammation. Inflammatory responses can be observed in asymptomatic asbestos\u2010exposed individuals. There are currently no interventions to reduce inflammatory or oxidative responses to asbestos before disease develops. We investigated the effects of oral\n N<\/jats:styled-content>\n \u2010acetylcysteine (\n NAC<\/jats:styled-content>\n ) on indicators of inflammation or oxidative stress in asymptomatic people previously exposed to asbestos.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A double\u2010blind, randomized, placebo\u2010controlled study was conducted to assess the effectiveness and safety of 1800\u2009mg of\n NAC<\/jats:styled-content>\n given orally over a period of 4 months. This was a proof of principle study. Effectiveness was assessed using indicators of inflammation or oxidation as primary end\u2013points. Serum levels of total combined thiols (cysteine, cysteinylglycine, glutathione and homocysteine) were used to monitor the\n NAC<\/jats:styled-content>\n supplementation.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Thirty\u2010four subjects were randomly allocated to\n NAC<\/jats:styled-content>\n and 32 to placebo. Serum levels of total combined thiols were similar between the groups after intervention. There were no differences in levels of inflammatory or oxidative stress end\u2013points between the groups. No adverse effects were identified.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n No evidence was found that\n NAC<\/jats:styled-content>\n supplementation replenishes total combined thiols in the blood of healthy subjects with a history of asbestos exposure. There was also no evidence of reduced indicators of inflammation or oxidative stress. Further studies should determine the conditions required to increase levels of total anti\u2010oxidant capacity in the blood and in the lungs of subjects with either asbestos\u2010related diseases or subclinical lung inflammation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.12592","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T06:34:56Z","timestamp":1436855696000},"page":"1102-1107","source":"Crossref","is-referenced-by-count":12,"title":["Effect of\n N<\/scp>\n \u2010acetylcysteine supplementation on oxidative stress status and alveolar inflammation in people exposed to asbestos: A double\u2010blind, randomized clinical trial"],"prefix":"10.1111","volume":"20","author":[{"given":"Helman","family":"Alfonso","sequence":"first","affiliation":[{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"},{"name":"School of Public Health Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Franklin","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Ching","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Path West Laboratory Medicine Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Croft","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Burcham","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nola","family":"Olsen","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Reid","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"},{"name":"Centre for Medical Research University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Joyce","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"de Klerk","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"},{"name":"Institute of Child Health Research University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AW (Bill)","family":"Musk","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"},{"name":"School of Medicine and Pharmacology University of Western Australia Perth Western Australia Australia"},{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"308","volume-title":"Occupational lung diseases","author":"Morgan 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Department of Biostatistics Vanderbilt University School of Medicine 2003."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7321.1123"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S51057"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.49.7.670"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.94.07030431"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01061422"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1248283"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006058401200312"},{"key":"e_1_2_7_35_1","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1183\/09031936.93.01090832","article-title":"Oral N\u2010acetylcysteine reduces selected humoral markers of inflammatory cell activity in BAL fluid from healthy smokers: correlation to effects on cellular variables","volume":"1","author":"Eklund A","year":"1988","journal-title":"Eur. Respir. 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Understanding movement through seed dispersal in the marine environment can be difficult due to the high spatial and temporal variability of ocean currents. We employed a mutually enriching approach of population genetic assignment procedures and dispersal predictions from a hydrodynamic model to overcome this difficulty and quantify the movement of dispersing floating fruit of the temperate seagrass Posidonia australis<\/jats:italic> Hook.f. across coastal waters in south\u2010western Australia. Dispersing fruit cohorts were collected from the water surface over two consecutive years, and seeds were genotyped using microsatellite DNA markers. Likelihood\u2010based genetic assignment tests were used to infer the meadow of origin for seed cohorts and individuals. A three\u2010dimensional hydrodynamic model was coupled with a particle transport model to simulate the movement of fruit at the water surface. Floating fruit cohorts were mainly assigned genetically to the nearest meadow, but significant genetic differentiation between cohort and most likely meadow of origin suggested a mixed origin. This was confirmed by genetic assignment of individual seeds from the same cohort to multiple meadows. The hydrodynamic model predicted 60% of fruit dispersed within 20\u00a0km, but that fruit was physically capable of dispersing beyond the study region. Concordance between these two independent measures of dispersal provides insight into the role of physical transport for long distance dispersal of fruit and the consequences for spatial genetic structuring of seagrass meadows.<\/jats:p>","DOI":"10.1111\/mec.14939","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T10:25:40Z","timestamp":1542191140000},"page":"5019-5034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Seeds in motion: Genetic assignment and hydrodynamic models demonstrate concordant patterns of seagrass dispersal"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5789-8945","authenticated-orcid":false,"given":"Elizabeth A.","family":"Sinclair","sequence":"first","affiliation":[{"name":"School of Biological Sciences University of Western Australia Crawley Western Australia Australia"},{"name":"Kings Park Science, Department of 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History"}},{"value":"2018-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:40Z","timestamp":1753889860912,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Background: In the light of growing global epidemic of T2D and related microvascular complications, it is important to find early detection marker for the disease. Circulating miRNAs serve as a potential biomarker for monitering the progression to DR in diabetic individuals.<\/jats:p>\n Hypothesis and Aims: miRNAs play a substantial role in metabolic homeostasis through regulation of multiple genes, and could serve as a prognostic biomarker in DR. This study aims to assess a functional role of selected miRNAs in the Qatari population recruited for the Qatar Genome Project through Qatar BioBank.<\/jats:p>\n Methods: Plasma samples from 470 T2D subjects with and without DR and 500 matched-healthy controls has been included in this study. Total RNA was extracted and the expression profiling of 56 miRNA that previously reported as a player in the pathogenesis of DR was performed using custom open array panel. The miRNA expression data were normalized using ath-mir159a. Statistical analysis was performed to study the association between the phenotypes (HbA1c, C-peptide, age, BMI) and miRNA.<\/jats:p>\n Results: The patients and controls phenotypic and miRNA expression data were analyzed to interepret the differential expression of the miRNA in DR subjects. Initial analysis by applying the generalized additive model reveals that six miRNA (hsa-miR-27a, hsa-miR-376c, hsa-miR-92a, hsa-miR-1 hsa-miR-223, and mmu-miR-451) were found to be significantly associated with DR (p&gt;0.05). Furthermore, two differentially expressed miRNAs, (hsa-miR-1274A and hsa-miR-24) found to be associated with higher level of C-peptide in DR patients, which suggest the correlation of these miRNAs with the glucose hemostasis and DR.<\/jats:p>\n Conclusion: The etiology of DR is unclear, and present treatments have limited effectiveness. The biomarkers and downstream functional studies are required to deepen the understanding of this chronic diseases and its complications.<\/jats:p>\n \n Disclosure<\/jats:title>\n A.S. Akil: None. S. Subash Padmajeya: None. L.A. Jerman: None. A. Al-Kurbi: None. A.M. Hussein: None. A. Hardikar: None. M. Joglekar: None. T. Habib: None. M. El Anbari: None. K. Fakhro: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-563-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:52Z","timestamp":1592238592000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["563-P: Differentially Expressed Plasma miRNAs Are Closely Associated with the Presence of Microvascular Complications in Type 2 Diabetes: The 1000 Qatar-Omics Study Cohort"],"prefix":"10.2337","volume":"69","author":[{"given":"AMMIRA S.","family":"AKIL","sequence":"first","affiliation":[{"name":"Doha, Qatar, Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUJITHA SUBASH","family":"PADMAJEYA","sequence":"additional","affiliation":[{"name":"Doha, Qatar, Sydney, Australia, Camperdown, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LAILA 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We explored patient perspectives of prednisolone use in RA.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients with RA registered with the Australian Rheumatology Association Database (ARAD) who had completed an ARAD questionnaire in the preceding 12 months were invited to participate in an online survey. Responses were linked to already collected respondent demographics, medication use, and patient\u2010reported outcome measures. The Beliefs about Medicine Questionnaire (BMQ) measured patient beliefs on medication necessity and concerns. Free\u2010text responses outlining reasons for stopping or declining prednisolone underwent thematic analysis using NVivo 12.<\/jats:p><\/jats:sec>Results<\/jats:title>The survey response rate was 79.6% (804\/1010), including 251 (31.2%) reporting current prednisolone use and 432 (53.7%) reporting previous use. Compared with previous users, current users were older (P<\/jats:italic> = 0.0002) and had worse self\u2010reported pain, disease activity, health\u2010related quality of life, and function (all P<\/jats:italic> < 0.001). Current users had higher BMQ scores for prednisolone\u2010specific necessity (3.6 versus 1.7; P<\/jats:italic> <0.001) and concerns (2.7 versus 2.3; P<\/jats:italic> <0.001). In previous prednisolone users (n = 432), the most frequent themes identified in free\u2010text responses for cessation were adequate disease control (30.3%), adverse effects (25.2%), and predetermined short courses (21.3%). Of respondents citing adverse effects for cessation (n = 131), weight gain (27.5%), osteoporosis (14.7%), and neuropsychiatric issues (13.8%) were most frequent.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In our cohort, patients with RA taking prednisolone believed it was necessary yet remained concerned about its use. Adequate disease control and adverse effects were important considerations for patients using prednisolone.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr2.11234","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T22:48:15Z","timestamp":1613861295000},"page":"231-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Perspectives of Glucocorticoid Use in Patients with Rheumatoid Arthritis"],"prefix":"10.1002","volume":"3","author":[{"given":"Gabriella","family":"Venter","sequence":"first","affiliation":[{"name":"The Queen Elizabeth Hospital, Woodville, South Australia, Australia, and University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2975-176X","authenticated-orcid":false,"given":"Joanna","family":"Tieu","sequence":"additional","affiliation":[{"name":"The Queen Elizabeth Hospital, Woodville, South Australia, Australia, and University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Black","sequence":"additional","affiliation":[{"name":"The Queen Elizabeth Hospital, Woodville, South Australia, Australia, and University of Adelaide and Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Lester","sequence":"additional","affiliation":[{"name":"The Queen Elizabeth Hospital, Woodville, South Australia, Australia, and University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5110-7439","authenticated-orcid":false,"given":"Nieves","family":"Leonardo","sequence":"additional","affiliation":[{"name":"The Queen Elizabeth Hospital Woodville South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel L.","family":"Whittle","sequence":"additional","affiliation":[{"name":"The Queen Elizabeth Hospital, Woodville, South Australia, Australia, and University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Hoon","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Barrett","sequence":"additional","affiliation":[{"name":"Redcliffe Hospital Redcliffe Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Rowett","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-0933","authenticated-orcid":false,"given":"Rachelle","family":"Buchbinder","sequence":"additional","affiliation":[{"name":"Monash University, Melbourne, Victoria, Australia, and Cabrini Institute Malvern Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-4922","authenticated-orcid":false,"given":"Catherine L.","family":"Hill","sequence":"additional","affiliation":[{"name":"The Queen Elizabeth Hospital, Woodville, South Australia, Australia, and University of Adelaide and Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507203330302"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-136-1-200201010-00006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0895-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker017"},{"key":"e_1_2_10_6_1","first-page":"696","article-title":"Corticosteroid use in rheumatoid arthritis: prevalence, predictors, correlates, and outcomes","volume":"34","author":"Caplan L","year":"2007","journal-title":"J 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URL:www.surveymonkey.com."},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/08870449908407311"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S166451"},{"key":"e_1_2_10_24_1","volume-title":"Stata statistical software: release 15.0","year":"2017"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-4-25"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.069252"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1461-3"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22365"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2016-000157"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu366"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200008)43:8<1801::AID-ANR16>3.0.CO;2-O"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu148"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-2953-7"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2008.08.004"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-014603"}],"container-title":["ACR Open Rheumatology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr2.11234","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr2.11234","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr2.11234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:26:28Z","timestamp":1759418788000},"score":7.6158624,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr2.11234"}},"issued":{"date-parts":[[2021,2,20]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/acr2.11234"],"URL":"https:\/\/doi.org\/10.1002\/acr2.11234","archive":["Portico"],"ISSN":["2578-5745","2578-5745"],"issn-type":[{"value":"2578-5745","type":"print"},{"value":"2578-5745","type":"electronic"}],"published":{"date-parts":[[2021,2,20]]},"assertion":[{"value":"2020-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T00:49:58Z","timestamp":1701478198701},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"12_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,12,1]]},"abstract":"Abstract<\/jats:title>\n The highly calcium selective ion channel TRPV6, has pronouced overexpression in many prostate cancers, is a promotor of prostate cancer growth and has been proposed as a prognostic marker in prostate cancer. A novel series of first-in-class TRPV6 inhibitors has been developed by the Queensland Emory Drug Discovery Initiative (QEDDI), a drug discovery and development group aiming to collaborativey translate academic biomedical research into new medicines. The preclinical lead drug candidate QED-203, is orally active and potently inhibits (low nM) calcium influx mediated by TRPV6 as assessed by both Ca2+ probe and electrophysiology assays, and TRPV6-driven NFAT activation as assessed by a luciferase reporter assay. Using RNAseq and qPCR analysis TRPV6 pharmacological inhibition and\/or siRNA-mediated silencing was shown to remodel the expression of genes related to both NFAT and WNT signalling, as well as ER stress and the cell cycle. In prostate cancer cell lines that had increased levels of TRPV6, TRPV6 inhibition promoted cell cycle arrest, decreased proliferation and promoted apoptosis. Proliferation of enzalutamide resistant prostate cancer cell lines was also inhibited by QED-203. QED-203 exhibited greater potency over enzalutamide, darolutamide and apalutamide [androgen receptor targeting agents (ARTA)] in prostate cancer cell lines with clinically relevant AR mutations or those with the ARV7 splice variant. QED-203 appeared well suited to once-a-day oral dosing with a high bioavailability and an advantageous pharmacokinetic profile. In preclinical models, QED-203 was well tolerated in rodents and had similar in vivo efficacy to enzalutamide in a castrated LNCaP mouse model of prostate cancer as assessed by tumour growth and PSA levels. Increases in urine calcium levels and gene expression changes consistent with TRPV6 inhibition in isolated xenograft tumours, confirmed QED-203 TRPV6 target engagement in vivo. These studies suggest that the orally active TRPV6 inhibitor QED-203 represents a first-in-class mechanism to treat prostate cancer patients whose tumours have become resistant to current ARTA therapies. Pharmacological inhibitors of TRPV6, could be particularly valuable during the advanced stages of prostate cancer, where there is a clear unmet clinical need.<\/jats:p>\n Citation Format: Gregory Monteith, Kimberley Beaumont, Rebecca Pouwer, Rebecca Farrow, Matthew McLachlan, Mei Yeh, Therese Johnson, Raphael Rahmani, Claire Levrier, Hasanthi Wijesekera, Malika Kumarasiri, Grant Stuchbury, Terrie-Anne Cock, Andrew Harvey, Brian Dymock. First-in-class orally active pharmacological inhibitors of TRPV6 for the treatment of advanced prostate cancer [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr B119.<\/jats:p>","DOI":"10.1158\/1535-7163.targ-23-b119","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T06:59:04Z","timestamp":1701413944000},"page":"B119-B119","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract B119: First-in-class orally active pharmacological inhibitors of TRPV6 for the treatment of advanced prostate cancer"],"prefix":"10.1158","volume":"22","author":[{"given":"Gregory","family":"Monteith","sequence":"first","affiliation":[{"name":"1The University of Queensland, Brisbane, QLD, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberley","family":"Beaumont","sequence":"additional","affiliation":[{"name":"2UniQuest, Brisbane, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Pouwer","sequence":"additional","affiliation":[{"name":"2UniQuest, Brisbane, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Farrow","sequence":"additional","affiliation":[{"name":"2UniQuest, Brisbane, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"McLachlan","sequence":"additional","affiliation":[{"name":"2UniQuest, Brisbane, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Yeh","sequence":"additional","affiliation":[{"name":"2UniQuest, Brisbane, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese","family":"Johnson","sequence":"additional","affiliation":[{"name":"2UniQuest, Brisbane, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Rahmani","sequence":"additional","affiliation":[{"name":"2UniQuest, Brisbane, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Levrier","sequence":"additional","affiliation":[{"name":"2UniQuest, Brisbane, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasanthi","family":"Wijesekera","sequence":"additional","affiliation":[{"name":"2UniQuest, Brisbane, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malika","family":"Kumarasiri","sequence":"additional","affiliation":[{"name":"2UniQuest, Brisbane, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant","family":"Stuchbury","sequence":"additional","affiliation":[{"name":"2UniQuest, Brisbane, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terrie-Anne","family":"Cock","sequence":"additional","affiliation":[{"name":"2UniQuest, Brisbane, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Harvey","sequence":"additional","affiliation":[{"name":"2UniQuest, Brisbane, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Dymock","sequence":"additional","affiliation":[{"name":"2UniQuest, Brisbane, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Molecular Cancer Therapeutics"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/mct\/article\/22\/12_Supplement\/B119\/730797\/Abstract-B119-First-in-class-orally-active","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/mct\/article\/22\/12_Supplement\/B119\/730797\/Abstract-B119-First-in-class-orally-active","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T06:59:05Z","timestamp":1701413945000},"score":7.61553,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/mct\/article\/22\/12_Supplement\/B119\/730797\/Abstract-B119-First-in-class-orally-active"}},"issued":{"date-parts":[[2023,12,1]]},"references-count":0,"journal-issue":{"issue":"12_Supplement","published-print":{"date-parts":[[2023,12,1]]}},"URL":"https:\/\/doi.org\/10.1158\/1535-7163.targ-23-b119","ISSN":["1538-8514"],"issn-type":[{"value":"1538-8514","type":"electronic"}],"published":{"date-parts":[[2023,12,1]]}},{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:20:49Z","timestamp":1784676049642,"version":"3.55.0"},"reference-count":107,"publisher":"Association for Computing Machinery (ACM)","issue":"4","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"funder":[{"DOI":"10.13039\/100008242","name":"NICTA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008242","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015539","name":"Australian Government","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015539","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000181","name":"Air Force Office of Scientific Research","doi-asserted-by":"publisher","award":["FA2386-12-1-4049"],"award-info":[{"award-number":["FA2386-12-1-4049"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000935","name":"Department of Broadband, Communications and the Digital Economy , Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000935","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ICT Center of Excellence program"}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":["ACM Trans. Interact. Intell. Syst."],"published-print":{"date-parts":[[2012,12]]},"abstract":"High cognitive load arises from complex time and safety-critical tasks, for example, mapping out flight paths, monitoring traffic, or even managing nuclear reactors, causing stress, errors, and lowered performance. Over the last five years, our research has focused on using the multimodal interaction paradigm to detect fluctuations in cognitive load in user behavior during system interaction. Cognitive load variations have been found to impact interactive behavior: by monitoring variations in specific modal input features executed in tasks of varying complexity, we gain an understanding of the communicative changes that occur when cognitive load is high. So far, we have identified specific changes in: speech, namely acoustic, prosodic, and linguistic changes; interactive gesture; and digital pen input, both interactive and freeform. As ground-truth measurements, galvanic skin response, subjective, and performance ratings have been used to verify task complexity.<\/jats:p>\n The data suggest that it is feasible to use features extracted from behavioral changes in multiple modal inputs as indices of cognitive load. The speech-based indicators of load, based on data collected from user studies in a variety of domains, have shown considerable promise. Scenarios include single-user and team-based tasks; think-aloud and interactive speech; and single-word, reading, and conversational speech, among others. Pen-based cognitive load indices have also been tested with some success, specifically with pen-gesture, handwriting, and freeform pen input, including diagraming. After examining some of the properties of these measurements, we present a multimodal fusion model, which is illustrated with quantitative examples from a case study.<\/jats:p>\n The feasibility of employing user input and behavior patterns as indices of cognitive load is supported by experimental evidence. Moreover, symptomatic cues of cognitive load derived from user behavior such as acoustic speech signals, transcribed text, digital pen trajectories of handwriting, and shapes pen, can be supported by well-established theoretical frameworks, including O'Donnell and Eggemeier's workload measurement [1986] Sweller's Cognitive Load Theory [Chandler and Sweller 1991], and Baddeley's model of modal working memory [1992] as well as McKinstry et al.'s [2008] and Rosenbaum's [2005] action dynamics work. The benefit of using this approach to determine the user's cognitive load in real time is that the data can be collected implicitly that is, during day-to-day use of intelligent interactive systems, thus overcomes problems of intrusiveness and increases applicability in real-world environments, while adapting information selection and presentation in a dynamic computer interface with reference to load.<\/jats:p>","DOI":"10.1145\/2395123.2395127","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T15:34:16Z","timestamp":1357659256000},"page":"1-36","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":103,"title":["Multimodal behavior and interaction as indicators of cognitive load"],"prefix":"10.1145","volume":"2","author":[{"given":"Fang","family":"Chen","sequence":"first","affiliation":[{"name":"NICTA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Ruiz","sequence":"additional","affiliation":[{"name":"NICTA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Choi","sequence":"additional","affiliation":[{"name":"NICTA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Epps","sequence":"additional","affiliation":[{"name":"NICTA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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In Proceedings of the IEEE International Conference on Acoustic, Speech and Signal Processing (ICASSP'10) . Yap, T. F., Epps, J., Choi, E., and Ambikairajah, E. 2010c. Glottal features for speech-based cognitive load classification. In Proceedings of the IEEE International Conference on Acoustic, Speech and Signal Processing (ICASSP'10)."},{"key":"e_1_2_1_102_1","doi-asserted-by":"crossref","unstructured":"Yin B. and Chen F. 2007. Towards automatic cognitive load measurement from speech analysis. In Human-Computer Interaction Interaction Design and Usability J. Jacko Ed. Springer 1011--1020. Yin B. and Chen F. 2007. Towards automatic cognitive load measurement from speech analysis. In Human-Computer Interaction Interaction Design and Usability J. Jacko Ed. 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Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: Despite evidence of impaired estimated insulin sensitivity (IS) in people with type 1 diabetes (T1D) with diabetic kidney disease (DKD) there are no available IS data using \u201cgold standard\u201d euglycemic hyperinsulinemic clamps.<\/jats:p>\n Methods: IS measured as glucose disposal rate (GDR) from the last 30 min of clamps conducted between 2006-2023 in 189 people with T1D (34 with DKD) at four centers (Finland, Poland and two in Australia) was compared in a two-stage meta-analysis. DKD diagnosis was based on albuminuria.<\/jats:p>\n Results: eGFR (CKD-Epi 2021 formula) was significantly lower in DKD (weighted median (LQ, UQ) 86.4 (66.2, 106.7) vs. 107.2 (100.5, 112.0) mg\/min\/1.73m2 (difference: -18.6 (-35.7, -1.6) mg\/min\/1.73m2, p=0.03) but with substantial heterogeneity: I2=88.4%, p&lt;0.0001. Age and HbA1c in DKD vs. no DKD were 37 (35, 55) vs. 35 (33, 38) yrs (difference: 0.9 (-9.7, 11.5) yrs, p=0.87, I2=89%, p&lt;0.0001) and 8.4\u00b11.7 vs. 7.4\u00b11.2% (difference: 0.8 (-0.4, 1.9)%, p=0.20, I2=86%, p&lt;0.0001), respectively. HDL-C was significantly lower in DKD: 1.4\u00b10.4 vs. 1.6\u00b10.5 mM (difference: -0.2 (-0.4, -0.1) mM, p=0.008, I2=0%, p=0.76). In individuals with T1D and DKD, IS was significantly lower vs no DKD (4.9 (4.0, 6.2) vs. 6.4 (4.5, 6.9) mg\/kg\/min, difference: -1.7 (-2.9, -0.5) mg\/kg\/min, (p=0.004, I2=35%, p=0.23). The difference was attenuated after adjustment for age, sex, HbA1c and lipids levels. Mean total daily insulin dose\/kg body weight was significantly higher in DKD: 0.60 (0.57, 0.68) vs. 0.48 (0.45, 0.58) IU\/kg (difference: 0.12 (0.06, 0.20) IU\/kg, p=0.0005, I2=0%, p=0.86).<\/jats:p>\n Conclusion: In a cross-sectional study of 189 people with T1D undergoing euglycemic hyperinsulinemic clamp studies, IS assessed by GDR was significantly worse in those with vs. without DKD. Additionally, those with vs. without DKD had lower HDL-C and eGFR and were taking more insulin.<\/jats:p>\n \n Disclosure<\/jats:title>\n A.S. Januszewski: None. J.R.A. Simonsen: None. A. Grzelka-Wozniak: Other Relationship; Novo Nordisk, Sanofi, Boehringer-Ingelheim, Roche Diabetes Care, Eli Lilly and Company. J.R. Snaith: None. N. Sachithanandan: None. G.M. Ward: None. D.N. O'Neal: None. L.M. Thorn: None. A. Jenkins: Advisory Panel; Abbott. Speaker's Bureau; GlaxoSmithKline plc. Research Support; Abbott, Metronics, Ypsomed AG, Insulet Corporation, Jaeb Center for Health Research, Endogenex, Hemsley Charitable Trust. Speaker's Bureau; CSL Seqirus. Research Support; AbbVie Inc, National Institutes of Health, Juvenile Diabetes Research Foundation (JDRF). J. Greenfield: Other Relationship; Novo Nordisk. Speaker's Bureau; Novartis AG, Amgen Inc, Lilly Diabetes, Boehringer-Ingelheim. A. Uruska: Other Relationship; Boehringer-Ingelheim, Eli Lilly and Company, AstraZeneca. D. Zozulinska-Ziolkiewicz: Speaker's Bureau; Abbott. Advisory Panel; Abbott. Speaker's Bureau; Ascensia Diabetes Care, Lilly Diabetes, Boehringer-Ingelheim, AstraZeneca, Novo Nordisk, Sanofi, Servier Laboratories. P. Groop: Speaker's Bureau; AstraZeneca, Bayer Pharmaceuticals, Inc, Berlin-Chemie AG, Boehringer-Ingelheim. Advisory Panel; Boehringer-Ingelheim. Speaker's Bureau; Novo Nordisk, Menarini.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-1584-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:46:59Z","timestamp":1749793619000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1584-P: Euglycemic Hyperinsulinemic Clamps Reveal Lower Insulin Sensitivity in Type 1 Diabetes Adults with vs. without Nephropathy"],"prefix":"10.2337","volume":"74","author":[{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"first","affiliation":[{"name":"Sydney NSW, Australia, Espoo, Finland, Fitzroy VIC, Australia, Fitzroy, Australia, Helsinki, Finland, Melbourne VIC, Australia, Darlinghurst NSW, Australia, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHAN R.A.","family":"SIMONSEN","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Espoo, Finland, Fitzroy VIC, Australia, Fitzroy, Australia, Helsinki, Finland, Melbourne VIC, Australia, Darlinghurst NSW, Australia, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AGATA","family":"GRZELKA-WOZNIAK","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Espoo, Finland, Fitzroy VIC, Australia, Fitzroy, Australia, Helsinki, Finland, Melbourne VIC, Australia, Darlinghurst NSW, Australia, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JENNIFER R.","family":"SNAITH","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Espoo, Finland, Fitzroy VIC, Australia, Fitzroy, Australia, Helsinki, Finland, Melbourne VIC, Australia, Darlinghurst NSW, Australia, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NIRUPA","family":"SACHITHANANDAN","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Espoo, Finland, Fitzroy VIC, Australia, Fitzroy, Australia, Helsinki, Finland, Melbourne VIC, Australia, Darlinghurst NSW, Australia, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GLENN M.","family":"WARD","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Espoo, Finland, Fitzroy VIC, Australia, Fitzroy, Australia, Helsinki, Finland, Melbourne VIC, Australia, Darlinghurst NSW, Australia, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Espoo, Finland, Fitzroy VIC, Australia, Fitzroy, Australia, Helsinki, Finland, Melbourne VIC, Australia, Darlinghurst NSW, Australia, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LENA M.","family":"THORN","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Espoo, Finland, Fitzroy VIC, Australia, Fitzroy, Australia, Helsinki, Finland, Melbourne VIC, Australia, Darlinghurst NSW, Australia, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Espoo, Finland, Fitzroy VIC, Australia, Fitzroy, Australia, Helsinki, Finland, Melbourne VIC, Australia, Darlinghurst NSW, Australia, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JERRY","family":"GREENFIELD","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Espoo, Finland, Fitzroy VIC, Australia, Fitzroy, Australia, Helsinki, Finland, Melbourne VIC, Australia, Darlinghurst NSW, Australia, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALEKSANDRA","family":"URUSKA","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Espoo, Finland, Fitzroy VIC, Australia, Fitzroy, Australia, Helsinki, Finland, Melbourne VIC, Australia, Darlinghurst NSW, Australia, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DOROTA","family":"ZOZULINSKA-ZIOLKIEWICZ","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Espoo, Finland, Fitzroy VIC, Australia, Fitzroy, Australia, Helsinki, Finland, Melbourne VIC, Australia, Darlinghurst NSW, Australia, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PER-HENRIK","family":"GROOP","sequence":"additional","affiliation":[{"name":"Sydney NSW, Australia, Espoo, Finland, Fitzroy VIC, Australia, Fitzroy, Australia, Helsinki, Finland, Melbourne VIC, Australia, Darlinghurst NSW, Australia, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1584-P\/159258\/1584-P-Euglycemic-Hyperinsulinemic-Clamps-Reveal","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1584-P\/159258\/1584-P-Euglycemic-Hyperinsulinemic-Clamps-Reveal","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T16:17:34Z","timestamp":1750436254000},"score":7.615176,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1584-P\/159258\/1584-P-Euglycemic-Hyperinsulinemic-Clamps-Reveal"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-1584-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"1584-P"},{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T14:34:13Z","timestamp":1648823653785},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_4","license":[{"start":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T00:00:00Z","timestamp":1576886400000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2019,12,20]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aim<\/jats:title>\n Past research has shown that compared with healthy peers, people with Parkinson\u2019s Disease (PD) generate poorer stepping responses and display reduced ability to adapt gait to unexpected targets and obstacles. However, the neural basis of these impairments in PD is unclear. Here, we aimed to investigate cortical activation in pre-frontal and motor areas using functional near-infrared spectroscopy (fNIRS) during stepping and gait adaptability in people with PD, compared with healthy adults.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Forty-four people with PD (&gt;40 years, Hoen & Yahr stage 1-3) and 44 healthy age and sex-matched healthy adults performed three cognitively-demanding stepping tasks and a test of gait adaptability. We recorded relative changes in oxy-haemoglobin (HbO) and deoxy-haemoglobin (HbR) concentrations in the dorsolateral prefrontal cortex, supplementary motor area, premotor cortex and primary cortex using fNIRS.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Data collection is ongoing with &gt;75% participants already assessed. We will conduct between group-comparisons to compare HbO and HbR concentrations in the selected regions of interest in the stepping and the gait adaptability tests. Physical and cognitive predictors of brain activation in each task in each group will also be computed using regression models.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Based on the results of our recent systematic review of fNIRS-recorded brain activation during walking tasks (1), we hypothesise that compared with healthy-aged matched peers, people with PD will show increased prefrontal and motor cortices activation during stepping and gait adaptability tests. This would suggest that people with PD require more attentional resources for safe walking.<\/jats:p>\n <\/jats:sec>\n \n Reference<\/jats:title>\n (1) Pelicioni et al. Prefrontal cortical activation measured by fNIRS during walking: effects of age, disease and secondary task. Peer J 2019; 7: e6833.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ageing\/afz164.161","type":"journal-article","created":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T10:08:04Z","timestamp":1576922884000},"page":"iv34-iv39","source":"Crossref","is-referenced-by-count":0,"title":["161 Brain Activation Assessed with Functional Near-Infrared Spectroscopy (FNIRS) During Stepping and Gait in Older People and Those with PD"],"prefix":"10.1093","volume":"48","author":[{"given":"Jasmine","family":"Menant","sequence":"first","affiliation":[{"name":"Neuroscience Research Australia NeuRA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Pelicioni","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia NeuRA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiro","family":"Okubo","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia NeuRA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Canning","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, University of Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daina","family":"Sturnieks","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia NeuRA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Lord","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia NeuRA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,12,20]]},"container-title":["Age and Ageing"],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ageing\/article-pdf\/48\/Supplement_4\/iv34\/31578832\/afz164.161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ageing\/article-pdf\/48\/Supplement_4\/iv34\/31578832\/afz164.161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T10:08:05Z","timestamp":1576922885000},"score":7.6151147,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ageing\/article\/48\/Supplement_4\/iv34\/5682180"}},"issued":{"date-parts":[[2019,12]]},"references-count":0,"journal-issue":{"issue":"Supplement_4","published-online":{"date-parts":[[2019,12,20]]},"published-print":{"date-parts":[[2019,12,20]]}},"URL":"https:\/\/doi.org\/10.1093\/ageing\/afz164.161","ISSN":["0002-0729","1468-2834"],"issn-type":[{"value":"0002-0729","type":"print"},{"value":"1468-2834","type":"electronic"}],"published-other":{"date-parts":[[2019,12]]},"published":{"date-parts":[[2019,12]]}},{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T21:49:26Z","timestamp":1782596966805,"version":"3.54.5"},"reference-count":62,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental DNA"],"published-print":{"date-parts":[[2025,5]]},"abstract":"ABSTRACT<\/jats:title>Passive sampling is an emerging method for environmental DNA (eDNA) sampling in aquatic environments. Passive eDNA collection methods are time efficient, inexpensive, and require minimal equipment, making them suited to high\u2010density sampling, especially in remote locations. Here we trial new passive eDNA sampling methods, which we term \u2018in vitro passive eDNA sampling\u2019; where a water aliquot is collected at a sampling location and passively sampled in a microcosm experiment, allowing for high\u2010density sampling while the researcher moves to other areas. Furthermore, we test whether agitating in\u00a0vitro passive samples improves DNA yield and biodiversity estimations. We show that at a species level, in\u00a0vitro passive sampling methods can return comparable species richness estimates to conventional filtration at both estuarine and inshore marine locations when analyzed as detections per unit of time taken to process the sample. In addition, agitating our in\u00a0vitro passive samples improved DNA yields by an average of 2.2\u00d7as opposed to in\u00a0vitro passive sampling without agitation, though both were significantly lower than filtration. These in\u00a0vitro approaches to eDNA sampling will suit cost\u2010 and time\u2010sensitive biological surveys, where access to equipment is restricted and the need to complete high\u2010density sampling over large spatial scales is paramount.<\/jats:p>","DOI":"10.1002\/edn3.70101","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T09:49:36Z","timestamp":1747734576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["In Vitro Passive eDNA Sampling Provides a Cost\u2010Effective Alternative for Large Scale Sample Collection"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8485-4879","authenticated-orcid":false,"given":"Samuel","family":"Thompson","sequence":"first","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Crawley Western Australia Australia"},{"name":"UWA Oceans Institute The University of Western Australia Crawley Western Australia Australia"},{"name":"School of Biological Sciences Curtin University Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Jarman","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Crawley Western Australia Australia"},{"name":"UWA Oceans Institute The University of Western Australia Crawley Western Australia Australia"},{"name":"School of Biological Sciences Curtin University Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kingsley","family":"Griffin","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Crawley Western Australia Australia"},{"name":"UWA Oceans Institute The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Heydenrych","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Crawley Western Australia Australia"},{"name":"UWA Oceans Institute The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Partridge","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Crawley Western Australia Australia"},{"name":"UWA Oceans Institute The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Langlois","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Crawley Western Australia Australia"},{"name":"UWA Oceans Institute The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecss.2023.108283"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185043"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176343"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10592-015-0775-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki063"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1071\/9781486314935"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ece3.3123"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755-0998.13640"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/edn3.74"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-01760-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pan3.10071"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c02506"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-018-0192-6"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0605-2"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000831"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocon.2014.11.018"},{"key":"e_1_2_9_19_1","volume-title":"Advances in Ecological Research","author":"Derocles 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F. G.Blanchet M.Friendly et\u00a0al.2022.\u201cVegan Community Ecology Package Version 2.6.\u201d"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1890\/070135"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/2041\u2010210X.14258"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/edn3.497"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2010.02201.x"},{"key":"e_1_2_9_47_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2023"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/d8020007"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.5670\/oceanog.2009.46"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11030296"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780198767220.001.0001"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.162322"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ece3.70705"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041732"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/edn3.21"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10201-016-0483-x"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.12206"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2020.605148"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3897\/mbmg.2.23297"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/edn3.491"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755-0998.13604"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12686-015-0465-z"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2019.00373"}],"container-title":["Environmental DNA"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/edn3.70101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T10:59:46Z","timestamp":1755773986000},"score":7.615045,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/edn3.70101"}},"issued":{"date-parts":[[2025,5]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/edn3.70101"],"URL":"https:\/\/doi.org\/10.1002\/edn3.70101","archive":["Portico"],"ISSN":["2637-4943","2637-4943"],"issn-type":[{"value":"2637-4943","type":"print"},{"value":"2637-4943","type":"electronic"}],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70101"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:20Z","timestamp":1753889840996,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Sotagliflozin is a dual sodium-dependent glucose transporter (SGLT) inhibitor with the potential to be cardio-protective in people with and without diabetes. Here, we used an ex vivo Langendorff reperfusion model to investigate if direct infusion with sotagliflozin in hearts from diabetic and healthy mice improves functional recovery from global ischemia. Male C57Bl\/6 mice were fed either a control chow (CON) or high fat diet (HFD; 60% of calories from fat) for 46-48 weeks. Fasting blood glucose measurements were performed and body composition measured using nuclear magnetic resonance. Constant pressure Langendorff perfusion experiments were performed on hearts from each diet group. Following equilibration, hearts were infused with either sotagliflozin (90 nM) or dimethyl sulfoxide (VEH) for 10 min prior to a 25 min period of global ischemia. The infusions were recommenced for the first 15 min of 45 min reperfusion. Post ischemic recovery was assessed as % baseline recovery. HFD mice were heavier (54 vs. 34 g) with increased fat mass (42 vs. 19 %) and increased fasting blood glucose (9.6 vs. 8.0 mmol\/L). Paradoxically, their functional recovery from global ischemia was, in general, better when compared with hearts from CON mice and there was no effect of sotagliflozin infusion. In CON mice, early post-ischemic coronary flow was greater with sotagliflozin infusion when compared with VEH. Functional recovery in dP\/dtmax and dP\/dtmin was also greater with sotagliflozin infusion when compared with VEH.<\/jats:p>\n In conclusion, HFD exerted a protective effect on heart function, despite inducing obesity and hyperglycemia. Ongoing studies are examining the effects of sotagliflozin in an alternative model of T2DM. In lean mice, sotagliflozin increased functional recovery from global ischemia, highlighting the potential benefits of an antidiabetic agent in acute coronary care.<\/jats:p>\n \n Disclosure<\/jats:title>\n E.S. Dorey: None. B. Cotter: None. T.P. Mullins: None. M.E. Reichelt: None. L.A. Gallo: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Diabetes Australia<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-2225-pub","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:49Z","timestamp":1592238589000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["2225-PUB: Direct Actions of the Dual SGLT1\/2 Inhibitor Sotagliflozin on Functional Recovery following Global Ischemia in Diabetic and Healthy Mouse Hearts"],"prefix":"10.2337","volume":"69","author":[{"given":"EMILY S.","family":"DOREY","sequence":"first","affiliation":[{"name":"Brisbane, Australia, Saint Lucia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BROOKE","family":"COTTER","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Saint Lucia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"THOMAS P.","family":"MULLINS","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Saint Lucia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MELISSA E.","family":"REICHELT","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Saint Lucia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LINDA A.","family":"GALLO","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Saint Lucia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/2225-PUB\/57618\/2225-PUB-Direct-Actions-of-the-Dual-SGLT1-2","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/2225-PUB\/57618\/2225-PUB-Direct-Actions-of-the-Dual-SGLT1-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:40:04Z","timestamp":1647164404000},"score":7.614918,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/2225-PUB\/57618\/2225-PUB-Direct-Actions-of-the-Dual-SGLT1-2"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-2225-pub","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"2225-PUB"},{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T21:50:00Z","timestamp":1782597000874,"version":"3.54.5"},"reference-count":59,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T00:00:00Z","timestamp":1469664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Assessment"],"published-print":{"date-parts":[[2017,4]]},"abstract":"This study presents a Rasch-derived short form of the Warwick-Edinburgh Mental Well-Being Scale for use as a screening tool in the general population. Data from 2,005 18- to 69-year-olds revealed problematic discrimination at specific thresholds. Estimation of model fit also deviated from Rasch model expectations. Following deletion of 4 items, the 10 remaining items indicated the data fitted the model. No items showed differential item functioning, thereby making comparisons of overall positive mental well-being for the different age, gender, and income groups valid and accurate. Cronbach\u2019s alpha and Rasch Person Separation Index indicated a strong degree of reliability. Overall, the 10-item scale challenges researchers and clinicians to reconsider the assessment of positive mental well-being.<\/jats:p>","DOI":"10.1177\/1073191115609995","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T21:42:38Z","timestamp":1444945358000},"page":"371-386","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Positive Mental Well-Being"],"prefix":"10.1177","volume":"24","author":[{"given":"Stephen","family":"Houghton","sequence":"first","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"},{"name":"University of Strathclyde, Glasgow, Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Wood","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Marais","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Ferguson","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Pettigrew","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,28]]},"reference":[{"issue":"1","key":"bibr1-1073191115609995","first-page":"95","volume":"9","author":"Andrich D.","year":"1982","journal-title":"Education Research and Perspectives"},{"key":"bibr2-1073191115609995","first-page":"307","volume-title":"International encyclopedia of education","author":"Andrich D.","year":"2009","edition":"3"},{"key":"bibr3-1073191115609995","doi-asserted-by":"publisher","DOI":"10.3102\/1076998611411913"},{"key":"bibr4-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1177\/0013164414534258"},{"key":"bibr5-1073191115609995","unstructured":"Andrich D., Sheridan B. E., Luo G. (2010). RUMM2030 [A Windows program for Rasch Unidimensional Models for Measurement]. Perth, Western Australia, Australia: RUMM Laboratory."},{"key":"bibr6-1073191115609995","unstructured":"Australian Bureau of Statistics. (2006). National Health Survey: Summary of results (CDATA01). Retrieved from http:\/\/www.abs.gov.au\/ausstats\/abs@.nsf\/mf\/4364.0"},{"key":"bibr7-1073191115609995","unstructured":"Australian Communications and Media Authority. (2012). Convergence and communications Report 1: Australian household consumers\u2019 take-up and use of voice communications services. Retrieved from http:\/\/www.acma.gov.au\/theACMA\/Library\/researchacma\/Research-reports\/research-report-convergence-and-communications"},{"key":"bibr8-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-012-0144-4"},{"key":"bibr9-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6973.170"},{"issue":"1","key":"bibr10-1073191115609995","first-page":"607","volume":"12","author":"Bohlig M.","year":"1998","journal-title":"Rasch Measurement Transactions"},{"key":"bibr11-1073191115609995","doi-asserted-by":"publisher","DOI":"10.4324\/9781410614575"},{"key":"bibr12-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-014-0879-z"},{"key":"bibr13-1073191115609995","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S14399"},{"key":"bibr14-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-487"},{"key":"bibr15-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2014.11.007"},{"key":"bibr16-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1037\/a0030834"},{"key":"bibr17-1073191115609995","unstructured":"Dolan P., Layard R., Metcalfe R. (2011). Measuring subjective well-being for public policy (Office for National Statistics). Retrieved from http:\/\/eprints.lse.ac.uk\/35420\/1\/measuring-subjective-wellbeing-for-public-policy.pdf"},{"key":"bibr18-1073191115609995","first-page":"35","volume-title":"Differential item functioning","author":"Dorans N. J.","year":"1993"},{"key":"bibr19-1073191115609995","first-page":"485","volume":"2","author":"Gremigni P.","year":"2011","journal-title":"Giornale Italiano di Psicologia"},{"key":"bibr20-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2008.10.007"},{"key":"bibr21-1073191115609995","doi-asserted-by":"publisher","DOI":"10.3310\/hta13120"},{"key":"bibr22-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707009993"},{"key":"bibr23-1073191115609995","first-page":"307","volume-title":"The science of well-being","author":"Hupert F. 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E.","year":"1993"},{"key":"bibr53-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.54.6.1063"},{"key":"bibr54-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1177\/0004867414538678"},{"key":"bibr55-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2005.08.036"},{"key":"bibr56-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1080\/03075079712331381121"},{"key":"bibr57-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1080\/13548506.2012.689842"},{"key":"bibr58-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-3992.1997.tb00606.x"},{"key":"bibr59-1073191115609995","doi-asserted-by":"publisher","DOI":"10.1177\/0748175614544686"}],"container-title":["Assessment"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1073191115609995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1073191115609995","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1073191115609995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:12:10Z","timestamp":1777378330000},"score":7.614596,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1073191115609995"}},"subtitle":["A Validation of a Rasch-Derived Version of the Warwick-Edinburgh Mental Well-Being Scale"],"issued":{"date-parts":[[2016,7,28]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1177\/1073191115609995"],"URL":"https:\/\/doi.org\/10.1177\/1073191115609995","ISSN":["1073-1911","1552-3489"],"issn-type":[{"value":"1073-1911","type":"print"},{"value":"1552-3489","type":"electronic"}],"published":{"date-parts":[[2016,7,28]]}},{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:58:47Z","timestamp":1768978727627,"version":"3.49.0"},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"2_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2026,1,20]]},"abstract":"Abstract<\/jats:title>\n \n Introduction:<\/jats:title>\n Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) with lutetium-177 (177Lu), a beta-emitter, with proven clinical benefit as treatment of prostate cancer (PC). Although emerging clinical data indicate better efficacy with alpha-emitters, the toxicities associated with actinium-225 (225Ac) may limit its broad application, and application in earlier lines of therapy. Lead-212 (212Pb), is a promising isotope for targeted alpha therapy with high linear energy transfer, a short half-life of 10.6 hours, and a simple decay scheme. These properties promote efficient killing of PSMA+ PC cells while limiting off-target toxicities. Here we present combined in vitro and in vivo models, omics approaches, and functional assays elucidating the intrinsic cellular mechanisms of response to 212Pb-PSMA RLT.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n 212Pb-ADVC001, a novel 212Pb-based PSMA-targeting RLT currently in Phase I\/II clinical development (NCT05720130) for the treatment of metastatic PC, was used as 212Pb RLT. The cytotoxic activity in PC cell lines was measured by cell viability assays and in vivo studies. The kinetic mechanisms associated with 212Pb-ADVC001 mediated cell-death were assessed in vitro and ex vivo using transcriptomics and proteomics approaches, and their impact on the PC cell cycle by flow cytometry.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n 212Pb-ADVC001 displayed potent cytotoxic activity with an average EC50 of 2.7, 7.2 and 3.3 kBq\/mL in PC cell lines PC-3-PIP (PSMAhigh), C4-2 (PSMAint) and LNCaP (PSMAint), respectively. Transcriptomic analysis of in vitro treated PC cells and proteomic analysis of tumors harvested longitudinally revealed multiple mechanisms of action involving DNA damage, cell cycle arrest and cell death, and immune response modulation. In vitro cell cycle experiment further confirmed that 212Pb-ADVC001 caused significant DNA damage, and reduced DNA content in the S-phase of the cell cycle with a concomitant increase in the G1 and G2\/M-phase arrest compared to 177Lu-PSMA-I&T (p&lt;0.05).<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Transcriptomic and proteomic analyses indicate multiple 212Pb-PSMA treatment mechanisms of action collectively resulting in effective cancer cell kill. Mechanistic studies furthered the understanding of PC radiobiology and cellular responses to beta- and alpha-based RLT with the identification of a cell cycle arrest in PC specifically induced by 212Pb-PSMA.<\/jats:p>\n <\/jats:sec>\n \n Citation Format:<\/jats:title>\n Feifei Liu, Melissa E. Monterosso, Didier Boucher, Anna Amiss, Stelle Shakti, Kwong Ching. Liu, Abby Sydes, Aneesha Jones, Jaimee Hesse, Chanwoo Kim, Aimee Horsfall, Kevin Kuan, William Tieu, Stephen Rose, Simon Puttick, Gary Li, Anna Karmann, Thomas Kryza. Deciphering the Mechanisms of Action of 212Pb-based PSMA-targeting Radioligand Therapies [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Innovations in Prostate Cancer Research and Treatment; 2026 Jan 20-22; Philadelphia PA. Philadelphia (PA): AACR; Cancer Res 2026;86(2_Suppl):Abstract nr B041.<\/jats:p>\n <\/jats:sec>","DOI":"10.1158\/1538-7445.prostateca26-b041","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T18:07:55Z","timestamp":1768932475000},"page":"B041-B041","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract B041: Deciphering the Mechanisms of Action of 212Pb-based PSMA-targeting Radioligand Therapies"],"prefix":"10.1158","volume":"86","author":[{"given":"Feifei","family":"Liu","sequence":"first","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa E.","family":"Monterosso","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Boucher","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Amiss","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stelle","family":"Shakti","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwong Ching.","family":"Liu","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abby","family":"Sydes","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneesha","family":"Jones","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, 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Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Rose","sequence":"additional","affiliation":[{"name":"3AdvanCell, Brisbae, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Puttick","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Li","sequence":"additional","affiliation":[{"name":"2AdvanCell, Sydney, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Karmann","sequence":"additional","affiliation":[{"name":"2AdvanCell, Sydney, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kryza","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/86\/2_Supplement\/B041\/771506\/Abstract-B041-Deciphering-the-Mechanisms-of-Action","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/86\/2_Supplement\/B041\/771506\/Abstract-B041-Deciphering-the-Mechanisms-of-Action","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T18:07:56Z","timestamp":1768932476000},"score":7.614483,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/86\/2_Supplement\/B041\/771506\/Abstract-B041-Deciphering-the-Mechanisms-of-Action"}},"issued":{"date-parts":[[2026,1,20]]},"references-count":0,"journal-issue":{"issue":"2_Supplement","published-print":{"date-parts":[[2026,1,20]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.prostateca26-b041","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2026,1,20]]}},{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T16:11:05Z","timestamp":1770394265380,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Retinal deposits of amyloid beta (A\u03b2) have been identified in the eye and has shown to have a greater impact on retinal thickness than age\u2010related effects. Therefore, retinal thickness could serve as a diagnostic marker, warranting further investigation as demand for accessible Alzheimer's disease (AD) screening grows. This study aims to evaluate correlations between blood\u2010based AD biomarkers and retinal thickness across different eye regions in amyloid\u2010negative and amyloid\u2010positive individuals.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n Optical coherence tomography (OCT) and AD plasma biomarkers NFL, A\u03b242, A\u03b240, GFAP were analysed in cognitively normal individuals (MMSE >24) aged 58\u201084 years, who previously undertook Positron Emission Tomography (PET) amyloid imaging. A centiloid (CL) cut\u2010off score of 20 was used to subgroup recruited participants into amyloid\u2010positive (\n n<\/jats:italic>\n \u00a0=\u00a05) and amyloid\u2010negative (\n n<\/jats:italic>\n \u00a0=\u00a05). Data was analysed in reference to eye (LE\/RE), image location (optic disc, macula) and ETDRS (early treatment diabetic retinal study) regions. R software was used to calculate Spearman correlation coefficients, with a significance level of\n p<\/jats:italic>\n \u00a0< 0.05.\n <\/jats:p>\n <\/jats:sec>\n \n Result<\/jats:title>\n \n Comparing correlation coefficients across both groups demonstrated the amyloid\u2010negative group having strong negative correlations between CL scores and total retinal thickness in only the peripapillary region (\n r<\/jats:italic>\n \u00a0=\u00a0\u20100.71 to \u20100.97,\n p<\/jats:italic>\n \u00a0=\u00a0 <0.05), where the amyloid\u2010positive group had negative correlations in both macular and peripapillary regions (\n r<\/jats:italic>\n \u00a0=\u00a0\u20100.71 to \u20131,\n p<\/jats:italic>\n \u00a0=\u00a0 <0.05). The amyloid\u2010negative group exhibited strong positive correlations with macular (\n r<\/jats:italic>\n \u00a0=\u00a00.8 to 0.94,\n p<\/jats:italic>\n \u00a0=\u00a0 <0.05) and outer disc peripapillary (\n r<\/jats:italic>\n \u00a0=\u00a00.7,\n p<\/jats:italic>\n \u00a0=\u00a0 <0.05) thickness to the A\u03b242\/A\u03b240 ratio. The amyloid\u2010positive groups retinal thicknesses across various regions had stronger negative associations of GFAP and NFL (\n r<\/jats:italic>\n \u00a0=\u00a0\u20100.7 to \u20100.9,\n p<\/jats:italic>\n \u00a0=\u00a0 <0.05) than the amyloid\u2010negative group (\n r<\/jats:italic>\n \u00a0=\u00a0\u20100.63 to \u20100.8,\n p<\/jats:italic>\n \u00a0=\u00a0 <0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n These findings suggest that total retinal thickness in the macular and peripapillary regions via OCT may correlate with AD biomarkers. Increased retinal thickness were associated with increased A\u03b242\/A\u039240 ratio and decreased retinal thickness associated with higher brain amyloid CL scores, and blood\u2010based GFAP and NFL biomarkers. Further study in larger cohorts is required to validate results.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz70856_102434","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T04:40:34Z","timestamp":1766724034000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlations between retinal thickness, brain and blood biomarkers in preclinical Alzheimer's disease: pilot"],"prefix":"10.1002","volume":"21","author":[{"given":"Isaiah\u2010Lorenzo De","family":"Guia","sequence":"first","affiliation":[{"name":"Macquarie University, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun","family":"Eslick","sequence":"additional","affiliation":[{"name":"Macquarie University, Macquarie Park, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swathi","family":"Kanduri","sequence":"additional","affiliation":[{"name":"Macquarie University, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purna","family":"Poudel","sequence":"additional","affiliation":[{"name":"Australian Alzheimer's Research Foundation, Perth, Western Australia, Australia"},{"name":"Edith Cowan University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Hone","sequence":"additional","affiliation":[{"name":"Australian Alzheimer's Research Foundation, Perth, Western Australia, Australia"},{"name":"Edith Cowan University, Perth, Western Australia, Australia"},{"name":"Lions Alzheimer's Foundation, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph N","family":"Martins","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia, Australia"},{"name":"Lions Alzheimer's Foundation, Perth, Western Australia, Australia"},{"name":"Alzheimer's Research Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,25]]},"container-title":["Alzheimer's & 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This study aimed to determine if these ethnic disparities are similar after migration to Australia. A national cross-sectional telephone survey asked participants what tasks they undertook in their job to assess exposure to carcinogens as well as whether they experienced ethnic discrimination, bullying, job precariousness, or job strain. A total of 389 New Zealand Caucasians and 152 M\u0101ori\/Pasifika workers were recruited. After adjustment, 79% of M\u0101ori\/Pasifika compared with 67% of New Zealand Caucasian workers were assessed as being exposed to at least one carcinogen at work. M\u0101ori\/Pasifika workers were also more likely to report ethnic discrimination and fair or poor current health than New Zealand Caucasians. Some ethnic disparities in exposure to workplace hazards in New Zealand are apparent after migration to Australia.<\/jats:p>","DOI":"10.1177\/10105395211007648","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T10:01:45Z","timestamp":1618308105000},"page":"870-879","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Are There Ethnic Disparities in Exposure to Workplace Hazards Among New Zealand Migrants to Australia?"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0152-5971","authenticated-orcid":false,"given":"Renee N.","family":"Carey","sequence":"first","affiliation":[{"name":"Curtin University, Bentley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"El-Zaemey","sequence":"additional","affiliation":[{"name":"Curtin University, Bentley, Western Australia, Australia"},{"name":"BreastScreen Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Daly","sequence":"additional","affiliation":[{"name":"Curtin University, Bentley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Fritschi","sequence":"additional","affiliation":[{"name":"Curtin University, Bentley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah C.","family":"Glass","sequence":"additional","affiliation":[{"name":"Monash University, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Reid","sequence":"additional","affiliation":[{"name":"Curtin University, Bentley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"bibr1-10105395211007648","volume-title":"Census of Population and Housing 2016","author":"Australian Bureau of Statistics","year":"2016"},{"key":"bibr2-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1136\/ip.7.1.22"},{"key":"bibr3-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1136\/injuryprev-2020-043643"},{"key":"bibr4-10105395211007648","volume-title":"Work-Related Traumatic Injury Fatalities, Australia 2016","author":"Safe Work Australia","year":"2016"},{"key":"bibr5-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1111\/1753-6405.12407"},{"key":"bibr6-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2007.038646"},{"key":"bibr7-10105395211007648","unstructured":"Ministry of Business Innovation and Employment. 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Accessed March 20, 2021. https:\/\/www.abs.gov.au\/ausstats\/abs@.nsf\/mf\/1270.0.55.005"},{"key":"bibr15-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2013-101651"},{"key":"bibr16-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqy126"},{"key":"bibr17-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-005-9029-0"},{"key":"bibr18-10105395211007648","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17207540"},{"key":"bibr19-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2009.048967"},{"key":"bibr20-10105395211007648","first-page":"67","volume":"9","author":"Leach LS","year":"2010","journal-title":"Aust Soc Policy J"},{"key":"bibr21-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"bibr22-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1177\/1536867x1401400104"},{"key":"bibr23-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"},{"key":"bibr24-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1063994968"},{"key":"bibr25-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.22428"},{"key":"bibr26-10105395211007648","first-page":"137","volume":"16","author":"Daldy B","year":"2013","journal-title":"Aust J Labour Econ"},{"key":"bibr27-10105395211007648","unstructured":"Markus A. Australians Today: The Australia@2015 Scanlon Foundation Survey. Accessed March 20, 2021. https:\/\/www.monash.edu\/__data\/assets\/pdf_file\/0009\/585918\/australians-today.pdf"},{"key":"bibr28-10105395211007648","first-page":"123","volume":"42","author":"Gardner D","year":"2013","journal-title":"NZ J Psychol"},{"key":"bibr29-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1080\/00779950109544330"},{"key":"bibr30-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2011.11.004"},{"key":"bibr31-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-014-0944-7"},{"key":"bibr32-10105395211007648","unstructured":"Statistics New Zealand. Labour market statistics (working life): December 2018 quarter. Accessed March 20, 2021. https:\/\/www.stats.govt.nz\/information-releases\/labour-market-statistics-working-life-december-2018-quarter"},{"key":"bibr33-10105395211007648","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17041448"},{"key":"bibr34-10105395211007648","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842x.1999.tb01279.x"}],"container-title":["Asia Pacific Journal of Public Health"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10105395211007648","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10105395211007648","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10105395211007648","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10105395211007648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:41:59Z","timestamp":1777376519000},"score":7.6142507,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10105395211007648"}},"issued":{"date-parts":[[2021,4,13]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1177\/10105395211007648"],"URL":"https:\/\/doi.org\/10.1177\/10105395211007648","ISSN":["1010-5395","1941-2479"],"issn-type":[{"value":"1010-5395","type":"print"},{"value":"1941-2479","type":"electronic"}],"published":{"date-parts":[[2021,4,13]]}},{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T01:00:53Z","timestamp":1780707653529,"version":"3.54.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2026,6,5]]},"abstract":"Introduction and Objective: Ethnic disparities in prediabetes and diabetes are well-documented globally but remain underexplored in Australian primary care settings. This study examined ethnic differences in the prevalence of prediabetes and diabetes and identified associated risk factors.<\/jats:p>\n Methods: Electronic health records of 60,887 adults (\u226518 years) from the General Practitioner Research Network (2014-2024) database were analysed. Glycaemic status was classified according to ADA criteria using fasting plasma glucose, HbA1c, or 2-hour oral glucose tolerance test. Logistic regression models estimated crude and adjusted odds ratios (AORs) with 95% confidence intervals for prediabetes and diabetes, controlling for age, sex, and Body Mass Index (BMI).<\/jats:p>\n Results: Participants were predominantly Europeans (63.8%), with smaller proportions of Sub-Saharan Africans (1.6%) and Hispanics (0.7%). Prediabetes prevalence ranged from 12.2% (9.3-15.6) among Hispanics to 23.7% (22.1-25.3) among South & Central Asians, while diabetes was highest among Pacific Peoples (11.6%, 10.0-13.4) and lowest among Hispanics (5.8%, 3.8-8.4). Compared with Europeans, the adjusted odds of diabetes and prediabetes were highest among Middle Eastern and North Africans (MENA) (AOR 3.16, 1.94-5.05) and South-East Asians (AOR 1.62, 1.24-2.10), respectively. Older age, obesity, hypertension, elevated triglycerides, widowhood, risky alcohol consumption, and current smoking status were consistently associated with higher odds of both conditions in most ethnic groups. In contrast, female sex and high HDL-cholesterol were protective.<\/jats:p>\n Conclusion: Marked ethnic heterogeneity exists in prediabetes and diabetes among Australian adults. Cardiometabolic and lifestyle factors contribute significantly to these disparities. Ethnicity-specific and culturally informed strategies are needed to improve screening, prevention, and early intervention, particularly for South & Central Asians, South-East Asians, Pacific Peoples, MENA, and Indigenous Australians.<\/jats:p>\n \n Disclosure<\/jats:title>\n N.E. Ezinne: None. K.E. Agho: None. A. Doyle: None. U.L. Osuagwu: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db26-2225-p","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:15:58Z","timestamp":1780704958000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["2225-P: Ethnic Disparities in the Prevalence and Risk Factors of Prediabetes and Diabetes in Australian Primary Care"],"prefix":"10.2337","volume":"75","author":[{"given":"NGOZIKA E.","family":"EZINNE","sequence":"first","affiliation":[{"name":"Campbelltown, Australia, Bathurst, Australia, Bathurst Rural Clinical School, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KINGSLEY E.","family":"AGHO","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Bathurst, Australia, Bathurst Rural Clinical School, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AUNTY-KERRIE","family":"DOYLE","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Bathurst, Australia, Bathurst Rural Clinical School, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"UCHECHUKWU L.","family":"OSUAGWU","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Bathurst, Australia, Bathurst Rural Clinical School, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/2225-P\/169066\/2225-P-Ethnic-Disparities-in-the-Prevalence-and","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/2225-P\/169066\/2225-P-Ethnic-Disparities-in-the-Prevalence-and","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:15:58Z","timestamp":1780704958000},"score":7.61419,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/2225-P\/169066\/2225-P-Ethnic-Disparities-in-the-Prevalence-and"}},"issued":{"date-parts":[[2026,6,5]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2026,6,5]]}},"URL":"https:\/\/doi.org\/10.2337\/db26-2225-p","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2026,6,5]]},"article-number":"2225-P"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:54:53Z","timestamp":1753876493318,"version":"3.41.2"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2021,5,11]]},"abstract":"Abstract<\/jats:title>\n \n Funding Acknowledgements<\/jats:title>\n Type of funding sources: Public grant(s) \u2013 National budget only. Main funding source(s): Australian Government National Health and Medical Research Council<\/jats:p>\n <\/jats:sec>\n \n OnBehalf<\/jats:title>\n ERASE project<\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n Rheumatic Heart Disease (RHD) is a major contributor to morbidity and mortality globally, and is endemic among Indigenous Australians. The RHD Endgame strategy was recently launched, outlining comprehensive methods for eliminating\u00a0RHD in Australia by 2031. However, there is currently limited information on national rates of RHD and progression to severe or complicated RHD.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n This study provides current estimates of RHD progression prior to RHD Endgame Strategy implementation. We estimate the probability and predictors of progressing from RHD diagnosis to cardiovascular complications, death, or need for surgical intervention in the Australian population from expanded data sources, addressing methodological shortcomings in existing evidence by using cross-jurisdictional administrative datasets and a competing risks approach.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective cohort study used linked RHD register, hospital and death data from five Australian jurisdictions (&gt;70% Australians). Progression from RHD diagnosis to all-cause mortality, non-fatal cardiovascular complications (heart failure, stroke, endocarditis, atrial fibrillation), or need for surgical intervention were estimated for people aged &lt;35years diagnosed with first-ever RHD between 2010 and 2018. A minimum 8.5-year look-back excluded prevalent cases; maximum follow-up was 8 years. Proportional cause-specific hazard regression modelling investigated independent predictors of outcomes, with death treated as a competing risk. \u00a0Sensitivity analyses compared results between all-sources and register-only cohorts.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n We identified 1714 first-ever RHD cases aged &lt;35years in the all-sources cohort (84% Indigenous, 11% migrant, 63% women, 40% age 5-14years, 85% non-metropolitan). Six months after diagnosis, 8.1% (95%CI:6.9-9.5%) had experienced heart failure, other cardiovascular complications or surgical intervention and 23.6% (95%CI:20.2-27.5%) progressed to these outcomes within 8\u00a0years. The register-only cohort experienced less disease progression with estimated composite event rates of 5.6% (95%CI:4.7-6.6%) and 18.4% (95%CI:16.6-20.5%) at 6 month and 8 years respectively. Death rate in the all-sources cohort was 0.5% at 6 months and 3.2% at 8 years. Older age, Metropolitan residence, and history of acute rheumatic fever, but not sex or Indigenous status, were independent predictors of major cardiovascular outcomes.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study provides the most definitive and contemporary estimates of RHD disease progression in young Australians. Despite Australia\"s excellent healthcare system infrastructure, RHD complication rates remain high. \u00a0Improvements in healthcare systems for diagnosis, monitoring, and management of RHD cases will need to be implemented in both Metropolitan and remote settings as Australia implements its Endgame strategy against RHD. However, primordial and primary prevention provides the best potential to reduce the burden of RHD in Australia and beyond.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwab061.109","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T19:37:13Z","timestamp":1620761833000},"source":"Crossref","is-referenced-by-count":0,"title":["Modelling rheumatic heart disease progression in australia using disease register data linked to administrative records"],"prefix":"10.1093","volume":"28","author":[{"given":"I","family":"Stacey","sequence":"first","affiliation":[{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hung","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Murray","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Seth","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Bond-Smith","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Katzenellenbogen","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,11]]},"container-title":["European Journal of Preventive Cardiology"],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/eurjpc\/article-pdf\/28\/Supplement_1\/zwab061.109\/37909154\/zwab061.109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/eurjpc\/article-pdf\/28\/Supplement_1\/zwab061.109\/37909154\/zwab061.109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T09:01:04Z","timestamp":1625734864000},"score":7.61419,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjpc\/article\/doi\/10.1093\/eurjpc\/zwab061.109\/6274021"}},"issued":{"date-parts":[[2021,5,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2021,5,11]]},"published-print":{"date-parts":[[2021,5,11]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjpc\/zwab061.109","ISSN":["2047-4873","2047-4881"],"issn-type":[{"type":"print","value":"2047-4873"},{"type":"electronic","value":"2047-4881"}],"published-other":{"date-parts":[[2021,5,1]]},"published":{"date-parts":[[2021,5,1]]},"article-number":"zwab061.109"},{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:14:27Z","timestamp":1788437667995,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2023,4]]},"abstract":"Background<\/jats:title>Women with type one diabetes experience poorer obstetric outcomes than normoglycaemic women in pregnancy.<\/jats:p><\/jats:sec>Objective<\/jats:title>To investigate the cost and clinical effectiveness of continuous glucose monitoring (GCM) compared to self\u2010monitoring of blood glucose in improving obstetric outcomes in women with type one diabetes during pregnancy.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>This retrospective cohort study included women with type one diabetes referred to a state\u2010wide tertiary obstetric centre before and after the introduction of government\u2010funded CGMs in Australia in March 2019. Forty\u2010nine women using CGMs were propensity matched on a range of clinical features with a historical group of 49 women with type one diabetes who exclusively used intermittent self\u2010monitoring of blood in the year prior to the introduction of funding of sensors. Medical records and administrative cost data were audited to quantify cost and clinical effectiveness.<\/jats:p><\/jats:sec>Results<\/jats:title>There were significantly lower pre\u2010term (95% CI 0.39\u20130.922; P<\/jats:italic>\u00a0=\u00a00.026) and very pre\u2010term birth rates (95% CI 1.002\u20131.184; P<\/jats:italic>\u00a0=\u00a00.041) in the CGM group. There was a significant reduction in the length of antenatal inpatient hospital stay (P<\/jats:italic>\u2009<\u20090.01) and adult special care unit stay (P<\/jats:italic>\u00a0=\u00a00.013) and neonatal admission to the neonatal intensive care unit (P<\/jats:italic>\u00a0=\u00a00.0262) in the continuous glucose monitoring group. CGMs represented a net cost saving to the health care sector of $12\u2009063 per pregnancy where the device was used, with an incremental cost\u2010effectiveness ratio of $3275 per prevented pre\u2010term birth.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>CGM use in pregnancy is a cost\u2010effective intervention for reducing the risk of pre\u2010term birth in women with type one diabetes, resulting in a net cost benefit to the health sector.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13581","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T07:34:44Z","timestamp":1657784084000},"page":"146-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Continuous glucose monitoring: A cost\u2010effective tool to reduce pre\u2010term birth rates in women with type one diabetes"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3044-9277","authenticated-orcid":false,"given":"Jasmin","family":"Sekhon","sequence":"first","affiliation":[{"name":"King Edward Memorial Hospital Perth Western Australia Australia"},{"name":"The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Graham","sequence":"additional","affiliation":[{"name":"King Edward Memorial Hospital Perth Western Australia Australia"},{"name":"The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chhaya","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"King Edward Memorial Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Li","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01644.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.626925"},{"key":"e_1_2_7_4_1","article-title":"Preconception care for diabetic women for improving maternal and infant health","volume":"8","author":"Tieu J","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0656"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2717"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32400-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2363-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1633-z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0500"},{"key":"e_1_2_7_11_1","first-page":"646","article-title":"Self\u2010monitoring blood glucose: non\u2010insulin\u2010treated type 2 diabetes in Australian general practice","volume":"42","author":"Henderson J","year":"2013","journal-title":"Aust Fam Physician"},{"key":"e_1_2_7_12_1","article-title":"Techniques of monitoring blood glucose during pregnancy for women with pre\u2010existing diabetes","volume":"5","author":"Jones LV","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_13_1","article-title":"Continuous glucose monitoring systems for type 1 diabetes mellitus","volume":"1","author":"Langendam M","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_14_1","unstructured":"In:Access to Subsidised Continuous Glucose Monitoring Products through the National Diabetes Services Scheme. Issue 1.Canberra:Department of Health;2019."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-008-0346-9"},{"issue":"2","key":"e_1_2_7_16_1","first-page":"175","article-title":"High spontaneous premature labor rate in insulin\u2010dependent diabetic pregnant women: An association with poor glycemic control and urogenital infection","volume":"72","author":"Mimouni F","year":"1988","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.107621"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14046"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2003.10.001"},{"key":"e_1_2_7_20_1","volume-title":"Baby Steps \u2013 Initial Findings Promising for Clinic","author":"Haynes K","year":"2015"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12962-018-0106-y"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.04.051"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307684"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1729"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-0635-z"}],"container-title":["Australian and New Zealand Journal of Obstetrics and Gynaecology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajo.13581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajo.13581","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajo.13581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T14:31:11Z","timestamp":1692628271000},"score":7.614007,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/ajo.13581"}},"issued":{"date-parts":[[2022,7,14]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/ajo.13581"],"URL":"https:\/\/doi.org\/10.1111\/ajo.13581","archive":["Portico"],"ISSN":["0004-8666","1479-828X"],"issn-type":[{"value":"0004-8666","type":"print"},{"value":"1479-828X","type":"electronic"}],"published":{"date-parts":[[2022,7,14]]},"assertion":[{"value":"2022-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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History"}}]},{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:57:17Z","timestamp":1787320637471,"version":"build-2736575974"},"reference-count":6,"publisher":"IEEE","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2025,4,28]]},"DOI":"10.1109\/msr66628.2025.00112","type":"proceedings-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T13:47:40Z","timestamp":1749822460000},"page":"756-757","source":"Crossref","is-referenced-by-count":4,"title":["Human-In-The-Loop Software Development Agents: Challenges and Future Directions"],"prefix":"10.1109","author":[{"given":"Jirat","family":"Pasuksmit","sequence":"first","affiliation":[{"name":"Atlassian,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wannita","family":"Takerngsaksiri","sequence":"additional","affiliation":[{"name":"Monash University,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patanamon","family":"Thongtanunam","sequence":"additional","affiliation":[{"name":"The University of Melbourne,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chakkrit","family":"Tantithamthavorn","sequence":"additional","affiliation":[{"name":"Monash University,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Atlassian,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Atlassian,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Atlassian,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Atlassian,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Cook","sequence":"additional","affiliation":[{"name":"Atlassian,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Chen","sequence":"additional","affiliation":[{"name":"Atlassian,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"Atlassian,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"263","reference":[{"key":"ref1","volume-title":"Introducing SWE-bench Verified","year":"2025"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2024.112113"},{"key":"ref3","article-title":"Swe-bench: Can language models resolve real-world github issues?","author":"Jimenez","year":"2023","journal-title":"arXiv preprint arXiv:2310.06770"},{"key":"ref4","article-title":"Human-In-the-Loop Software Development Agents","author":"Takerngsaksiri","year":"2024","journal-title":"arXiv preprint arXiv:2411.12924"},{"key":"ref5","first-page":"20032","article-title":"CodeJudge: Evaluating Code Generation with Large Language Models","volume-title":"In Proceedings of the 2024 Conference on Empirical Methods in Natural Language Processing","author":"Tong"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.18653\/v1\/2023.acl-long.773"}],"event":{"name":"2025 IEEE\/ACM 22nd International Conference on Mining Software Repositories (MSR)","location":"Ottawa, ON, Canada","start":{"date-parts":[[2025,4,28]]},"end":{"date-parts":[[2025,4,29]]}},"container-title":["2025 IEEE\/ACM 22nd International Conference on Mining Software Repositories (MSR)"],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/11025548\/11025536\/11025667.pdf?arnumber=11025667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T01:08:29Z","timestamp":1749863309000},"score":7.6135793,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11025667\/"}},"issued":{"date-parts":[[2025,4,28]]},"references-count":6,"URL":"https:\/\/doi.org\/10.1109\/msr66628.2025.00112","published":{"date-parts":[[2025,4,28]]}},{"indexed":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T04:09:55Z","timestamp":1681272595818},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2021,10,7]]},"abstract":"Abstract<\/jats:title>\n Nightwork disrupts circadian rhythms and impairs glucose metabolism, increasing the risk for type 2 diabetes. We investigated eliminating or reducing the amount of food consumed during simulated nightwork as a countermeasure to reduce the impact of circadian disruption on glucose metabolism. N=52 healthy, non-shiftworking participants (24.4\u00b14.9 years; 26 Females; BMI 23.8\u00b12.5kg\/m2) underwent a 7-day laboratory protocol with an 8h TIB baseline sleep, followed by 4 simulated nightshifts with 7h TIB daytime sleep and an 8h TIB recovery sleep in groups of 4 participants. Each group was randomly assigned to a meal-at-midnight (n=17, 30% energy requirements), snack-at-midnight (n=16, 10% energy requirements) or no-eating-at-midnight (n=19) condition. Total 24h energy and macronutrient intake were constant across conditions. Standard oral glucose tolerance tests (OGTT) were conducted on day2 (baseline), and day7 (recovery). Plasma was sampled at -15, 0, 15, 30, 60, 90, 120, 150 mins, assayed for glucose and insulin. Area under the curve (AUC) was the calculated. Mixed model analyses of glucose AUC found a condition-by-day interaction (p&lt;0.001). Glucose responses to OGTT did not change with nightwork in the no-eating-at-midnight condition (p=0.219) but worsened in the meal-at-midnight (p&lt;0.001) and snack-at-midnight (p=0.022) conditions. Insulin AUC was different by condition (p=0.047). Insulin was highest after nightwork in the no-eating-at-midnight compared to meal-at-midnight (p=0.014) but not snack-at-midnight (p=0.345). Glucose tolerance was impaired by eating-at-midnight, associated with a lower than expected insulin response. Further work is required to determine the effect of meal or snack composition as a strategy to mitigate adverse metabolic effects of nightwork.<\/jats:p>","DOI":"10.1093\/sleepadvances\/zpab014.056","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T17:20:11Z","timestamp":1633627211000},"page":"A23-A24","source":"Crossref","is-referenced-by-count":0,"title":["P007 Eating in alignment with the circadian clock: A strategy to reduce the metabolic impact of nightwork"],"prefix":"10.1093","volume":"2","author":[{"given":"S","family":"Centofanti","sequence":"first","affiliation":[{"name":"University Of South Australia , Magill , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Heilbronn","sequence":"additional","affiliation":[{"name":"University of Adelaide , Adelaide , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Wittert","sequence":"additional","affiliation":[{"name":"University of Adelaide , Adelaide , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Coates","sequence":"additional","affiliation":[{"name":"University Of South Australia , Magill , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Dorrian","sequence":"additional","affiliation":[{"name":"University Of South Australia , Magill , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Kennaway","sequence":"additional","affiliation":[{"name":"University of Adelaide , Adelaide , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Gupta","sequence":"additional","affiliation":[{"name":"Central Queensland University , Adelaide , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Stepien","sequence":"additional","affiliation":[{"name":"University Of South Australia , Magill , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Catcheside","sequence":"additional","affiliation":[{"name":"Flinders University of South Australia , Bedford Park , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Noakes","sequence":"additional","affiliation":[{"name":"CSIRO , Adelaide , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Yates","sequence":"additional","affiliation":[{"name":"University Of South Australia , Magill , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Matthews","sequence":"additional","affiliation":[{"name":"University Of South Australia , Magill , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Banks","sequence":"additional","affiliation":[{"name":"University Of South Australia , Magill , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,7]]},"container-title":["SLEEP Advances"],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/sleepadvances\/article-pdf\/2\/Supplement_1\/A23\/49843677\/zpab014.056.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/sleepadvances\/article-pdf\/2\/Supplement_1\/A23\/49843677\/zpab014.056.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T15:50:08Z","timestamp":1681228208000},"score":7.6134644,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleepadvances\/article\/2\/Supplement_1\/A23\/6383288"}},"issued":{"date-parts":[[2021,10,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2021,10,7]]}},"URL":"https:\/\/doi.org\/10.1093\/sleepadvances\/zpab014.056","ISSN":["2632-5012"],"issn-type":[{"value":"2632-5012","type":"electronic"}],"published-other":{"date-parts":[[2021,10,1]]},"published":{"date-parts":[[2021,10,1]]}},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T04:11:50Z","timestamp":1651205510274},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.juro.2014.02.916","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T19:32:51Z","timestamp":1396035171000},"source":"Crossref","is-referenced-by-count":0,"title":["MP31-07 ESTROGEN RECEPTOR \u03b1 REGULATES PROLIFERATION IN PTEN NULL PROSTATE CANCER"],"prefix":"10.1097","volume":"191","author":[{"given":"Itsuhiro","family":"Takizawa","sequence":"first","affiliation":[{"name":"Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Clayton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Pearson","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Normand","family":"Pouliot","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Australian","family":"Prostate","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cancer","family":"BioResource","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Humbert","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Furic","sequence":"additional","affiliation":[{"name":"Clayton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Risbridger","sequence":"additional","affiliation":[{"name":"Clayton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534714011744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534714011744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2014.02.916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:43:05Z","timestamp":1651203785000},"score":7.613379,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2014.02.916"}},"issued":{"date-parts":[[2014,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1016\/j.juro.2014.02.916"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2014.02.916","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2014,4]]}},{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T01:09:45Z","timestamp":1648688985099},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_3","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2020,12,4]]},"abstract":"Abstract<\/jats:title>\n Treatment for medulloblastoma involves craniospinal irradiation which is associated with devastating late effects. Clinical trials that simply reduce radiotherapy dosage have resulted in inferior survival rates, whereas new chemo\/radiotherapy combinations that improve survival have been identified using preclinical models. However, the potential late effects of novel treatments are currently understudied and the assessment of radiation-induced late effects in mice remains challenging. Here, we aimed to measure the effect of multifractionated radiotherapy on the juvenile mouse brain as a baseline measure for future studies. NOD\/Rag1-\/- mice received either 8Gy whole-brain radiotherapy (WBRT) using an X-RAD SmART preclinical platform, 18Gy fractionated WBRT (9x2Gy doses), single, or multiple sham treatments beginning at postnatal day (P)16. Mice were aged to adulthood (&gt;P63), then high resolution anatomical brain scans were obtained on a Bruker 9.4T MRI to measure the effects of WBRT on whole brain and specific regional area volumes. A single 8Gy dose (n=10) markedly reduced brain volume by 8.5% compared to single-sham controls (n=11, p&lt;0.0001), whereas fractionated 18Gy treatment (n=7) did not cause significant differences in brain volume compared to multi-sham controls (n=4, p&gt;0.99). Current analyses are focused on measuring treatment effects on specific areas of the brain, as well as other anatomical differences using a range of MRI techniques. These results will serve as a valuable tool to measure potential treatment-associated effects caused by novel chemo\/radiotherapy combinations on the developing brain. This will enable future studies to assess the potential safety of novel treatment to inform clinical decision making.<\/jats:p>","DOI":"10.1093\/neuonc\/noaa222.775","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T06:05:25Z","timestamp":1607061925000},"page":"iii456-iii456","source":"Crossref","is-referenced-by-count":0,"title":["RONC-02. MEASURING THE EFFECT OF CLINICALLY-RELEVANT RADIOTHERAPY PROTOCOLS ON THE JUVENILE MOUSE BRAIN"],"prefix":"10.1093","volume":"22","author":[{"given":"Jessica","family":"Buck","sequence":"first","affiliation":[{"name":"Telethon Kids Institute, Perth, Australia"},{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kale","family":"Somers","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Whitehouse","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth, Australia"},{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meegan","family":"Howlett","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth, Australia"},{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Hii","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke","family":"Strowger","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Ebert","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Australia"},{"name":"Sir Charles Gairdner Hospital, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Mehnert","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Gottardo","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth, Australia"},{"name":"Perth Children\u2019s Hospital, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raelene","family":"Endersby","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth, Australia"},{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,4]]},"container-title":["Neuro-Oncology"],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/22\/Supplement_3\/iii456\/34688443\/noaa222.775.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/22\/Supplement_3\/iii456\/34688443\/noaa222.775.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T06:05:26Z","timestamp":1607061926000},"score":7.6132984,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article\/22\/Supplement_3\/iii456\/6019316"}},"issued":{"date-parts":[[2020,12,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_3","published-online":{"date-parts":[[2020,12,4]]},"published-print":{"date-parts":[[2020,12,4]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noaa222.775","ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,12,1]]}},{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:00:15Z","timestamp":1773903615652,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012505","name":"Royal Perth Hospital Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Radiation Sci"],"published-print":{"date-parts":[[2023,9]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Impalpable breast lesions generally require image\u2010guided localisation for breast\u2010conserving surgery. A standard technique is to place a hook wire (HW) within the lesion. Radioguided occult lesion localisation using iodine seeds (ROLLIS) involves inserting a 4.5\u2009mm iodine\u2010125 seed (seed) into the lesion. We hypothesised that a seed could be more precisely positioned in relation to the lesion than a HW and that this may be associated with a lower re\u2010excision rate.<\/jats:p><\/jats:sec>Methods<\/jats:title>Retrospective review of consecutive participant data from three ROLLIS RCT (ACTRN12613000655741) sites. Participants underwent preoperative lesion localisation (PLL) with seed or HW between September 2013 and December 2017. Lesion and procedural characteristics were recorded. Distances between (1) any part of the seed or thickened segment of the HW (\u2018TSHW\u2019) and the lesion\/clip (\u2018distance to device\u2019 DTD) and (2) centre of the TSHW\/seed and centre of the lesion\/clip (device centre to target centre \u2018DCTC\u2019) were measured on immediate postinsertion mammograms. Pathological margin involvement and re\u2010excision rates were compared.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 390 lesions (190 ROLLIS and 200 HWL) were analysed. Lesion characteristics and guidance modality used were similar between groups. Ultrasound\u2010guided DTD and DCTC for seed were smaller than for HW (77.1% and 60.6%, respectively, P<\/jats:italic>\u2010value\u2009<\u20090.001). Stereotactic\u2010guided DCTC for seeds\u00a0was 41.6% smaller than for HW (P<\/jats:italic>\u2010value\u2009=\u20090.001). No statistically significant difference in the re\u2010excision rates was found.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Iodine\u2010125 seeds can be more precisely positioned for preoperative lesion localisation than HW, however, no statistically significant difference in re\u2010excision rates was detected.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmrs.687","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T08:22:36Z","timestamp":1684311756000},"page":"218-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Localisation accuracy with iodine\u2010125 seed versus wire guidance for breast cancer surgery"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6515-9560","authenticated-orcid":false,"given":"Shoba","family":"Ratnagobal","sequence":"first","affiliation":[{"name":"Breast Clinic, Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1481-1141","authenticated-orcid":false,"given":"Donna","family":"Taylor","sequence":"additional","affiliation":[{"name":"Breast Clinic, Royal Perth Hospital Perth Western Australia Australia"},{"name":"BreastScreen WA, Eastpoint Plaza Perth Western Australia Australia"},{"name":"Medical School The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1401-6674","authenticated-orcid":false,"given":"Anita G.","family":"Bourke","sequence":"additional","affiliation":[{"name":"BreastScreen WA, Eastpoint Plaza Perth Western Australia Australia"},{"name":"Medical School The University of Western Australia Crawley Western Australia Australia"},{"name":"Breast Centre, Sir Charles Gairdner Hospital Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4833-6457","authenticated-orcid":false,"given":"Meredith","family":"Kessell","sequence":"additional","affiliation":[{"name":"Breast Clinic, Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Madeley","sequence":"additional","affiliation":[{"name":"BreastScreen WA, Eastpoint Plaza Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie C.","family":"Robert","sequence":"additional","affiliation":[{"name":"BreastScreen WA, Eastpoint Plaza Perth Western Australia Australia"},{"name":"Breast Centre, Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8603-357X","authenticated-orcid":false,"given":"Philip","family":"Vlaskovsky","sequence":"additional","affiliation":[{"name":"Medical School The University of Western Australia Crawley Western Australia Australia"},{"name":"Biostatistical Unit Royal Perth Hospital Research Foundation Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2281-9829","authenticated-orcid":false,"given":"Christobel","family":"Saunders","sequence":"additional","affiliation":[{"name":"Breast Clinic, Royal Perth Hospital Perth Western Australia Australia"},{"name":"Medical School The University of Western Australia Crawley Western Australia Australia"},{"name":"Breast Centre, Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Cancer Council.Breast Cancer Australia. 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Sciences"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmrs.687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:48:10Z","timestamp":1694666890000},"score":7.6131864,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmrs.687"}},"issued":{"date-parts":[[2023,5,17]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/jmrs.687"],"URL":"https:\/\/doi.org\/10.1002\/jmrs.687","archive":["Portico"],"ISSN":["2051-3895","2051-3909"],"issn-type":[{"value":"2051-3895","type":"print"},{"value":"2051-3909","type":"electronic"}],"published":{"date-parts":[[2023,5,17]]},"assertion":[{"value":"2022-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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Doppler rate) estimation and decoding of transmission over channels affected by Doppler shift and Doppler rate using a distributed receiver. This algorithm is derived by applying the sum\u2010product algorithm (SPA) to a factor graph representing the joint a posteriori distribution of the information symbols and channel parameters given the channel output. In this paper, we present two methods for dealing with intractable messages of the SPA. In the first approach, we use particle filtering with sequential importance sampling for the estimation of the unknown parameters. We also propose a method for fine\u2010tuning of particles for improved convergence. In the second approach, we approximate our model with a random walk phase model, followed by a phase tracking algorithm and polynomial regression algorithm to estimate the unknown parameters. We derive the Weighted Bayesian Cramer\u2010Rao Bounds for joint carrier phase, Doppler shift, and Doppler rate estimation, which take into account the prior distribution of the estimation parameters and are accurate lower bounds for all considered signal\u2010to\u2010noise ratio values. Numerical results (of bit error rate and the mean\u2010square error of parameter estimation) suggest that phase tracking with the random walk model slightly outperforms particle filtering. However, particle filtering has a lower computational cost than the random walk model\u2010based method.<\/jats:p>","DOI":"10.1002\/sat.1460","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T04:10:32Z","timestamp":1658808632000},"page":"59-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Joint parameter estimation and decoding in a distributed receiver"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5549-6838","authenticated-orcid":false,"given":"Ahsan","family":"Waqas","sequence":"first","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6406-0932","authenticated-orcid":false,"given":"Khoa","family":"Nguyen","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8752-6440","authenticated-orcid":false,"given":"Gottfried","family":"Lechner","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6550-7203","authenticated-orcid":false,"given":"Terence","family":"Chan","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1109\/TWC.2015.2497687"},{"key":"e_1_2_13_3_1","doi-asserted-by":"crossref","unstructured":"YanH HannaS BalkeK GuptaR CabricD.Software defined radio implementation of carrier and timing synchronization for distributed arrays. 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While self-compassion has shown various benefits in the general population, its application in supporting autistic individuals remains limited. This study investigated the experiences of 39 autistic adults who participated in an autism-specific online self-compassion program. The program included a series of five modules which incorporated psychoeducation, meditation, and self-reflective exercises that were completed over a 5-week period. Qualitative data was collected through weekly check-ins and a post-program survey, which underwent thematic analysis through the lens of an autistic researcher resulting in four key themes: the positive impact of self-compassion, challenges faced during the program, recognizing self-compassion as a journey, and the value of program adaptations. These findings shed light on the experiences of autistic adults engaging with self-compassion interventions, highlighting both the benefits and barriers they encountered. The study underscores the importance of developing tailored interventions that consider the unique needs and perspectives of autistic individuals to promote improved mental health outcomes and foster inclusivity.<\/jats:p>\n \n Lay abstract<\/jats:title>\n Autistic people often struggle to find the right support for their mental health. We wanted to change that by trying a new approach to help autistic adults with their emotions and well-being. We focused on something called \u201cself-compassion,\u201d which is a way of being kind and understanding toward ourselves. This approach has worked well for many people, but we didn\u2019t know if it would work for autistic individuals. We invited 39 autistic adults to join an online program that taught them about self-compassion. The program lasted 5\u2009weeks and included educational materials, meditation exercises, and self-reflection activities. We asked the participants for feedback each week and at the end of the program. From their responses, we discovered four important things. First, self-compassion had a big positive impact on the well-being of autistic adults. Second, they faced some challenges during the program. Third, they saw self-compassion as a journey that takes time and practice. Finally, they described how they valued changes to help autistic people engage with the program. Our findings show that self-compassion can really help autistic adults. We learned about the benefits they experienced and the difficulties they faced. Most importantly, we found that personalized support is crucial for autistic individuals. By creating programs that consider their specific needs, we can improve their mental health and make their lives better.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/13623613241234097","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:33:22Z","timestamp":1708562002000},"page":"1419-1430","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["A qualitative exploration of an autism-specific self-compassion program: The ASPAA"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-674X","authenticated-orcid":false,"given":"Chris","family":"Edwards","sequence":"first","affiliation":[{"name":"Autism Spectrum Australia, Australia"},{"name":"Griffith University, 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Technologies (Wolters Kluwer Health)","issue":"Supplement 4","content-domain":{"domain":["www.auajournals.org"],"crossmark-restriction":true},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1097\/01.ju.0000556690.39331.8d","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T05:40:57Z","timestamp":1556084457000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["MP54-05\u2003LOWER URINARY TRACT SYMPTOMS (LUTS) AFTER ROBOTIC ASSISTED LAPAROSCOPIC PROSTATECTOMY (RALP) IN A LARGE, MULTI-SURGEON COHORT: IMPLICATIONS FOR SURVIVORSHIP AND TREATMENT SELECTION"],"prefix":"10.1097","volume":"201","author":[{"given":"Thomas","family":"Ahn","sequence":"first","affiliation":[{"name":"Brisbane, 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Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,6,14]]},"abstract":"Background: The abundant plasma protein Hp has anti-oxidant and anti-inflammatory effects. Its genotype\/phenotype modulates chronic diabetes complication risk and fenofibrate benefit on coronary artery and kidney disease in type 2 diabetes (T2D). It is unknown whether Hp phenotype and level are associated with risk of sight-threatening diabetic retinopathy (STDR) and fenofibrate benefit. Fenofibrate reduced STDR risk by 31% in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial.<\/jats:p>\n Methods: Hp phenotype and level were measured in 8047 FIELD subjects at baseline and randomization (after a 16-week run-in with fenofibrate in the last 6-weeks).<\/jats:p>\n Results: There were 307 on-trial STDR events over 5 years. Hp phenotype and baseline levels were not related to STDR risk. Fenofibrate benefit on STDR risk appeared greater for the Hp 2-1\/2-2 phenotypes, but p for heterogeneity was &gt;0.05 (Table 1). During run-in fenofibrate reduced Hp level by 20.7%, p&lt;0.001. Fenofibrate benefit was greatest in those with the lowest tertile of baseline Hp levels as well as among those in whom Hp levels decreased least with treatment.<\/jats:p>\n Conclusion: Whilst baseline Hp levels and phenotype are not strongly related to STDR risk in T2D Hp levels and phenotype identify subjects more likely to benefit from fenofibrate.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n K. Ong: None. A.S. Januszewski: None. H. Francis: None. A.O. Mangani: None. R.L. O'Connell: None. A. Jenkins: Research Support; Abbott, Viatris Inc. Advisory Panel; Abbott. Research Support; Medtronic. Board Member; Insulin for Life. Research Support; Leona M. and Harry B. Helmsley Charitable Trust, Juvenile Diabetes Research Foundation (JDRF), Jaeb Center for Health Research, National Institutes of Health, National Health and Medical Research Council Australia. A.C. Keech: Research Support; Abbott, Amgen Inc., Bayer Inc., Kowa Company, Ltd., Mylan. Speaker's Bureau; Novartis Pharmaceuticals Corporation. Research Support; Novartis Pharmaceuticals Corporation, Sanofi, Viatris Inc.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Laboratoires Fournier, Dijon, France and the National Health and Medical Research Council of Australia (NHMRC) (457103, 1024105, 1037786, 1105467)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db24-321-or","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T05:43:50Z","timestamp":1718343830000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["321-OR: Haptoglobin (Hp) Levels and Phenotype Are Unrelated to Severe Retinopathy in Type 2 Diabetes, but Lower Hp Reductions by Fenofibrate Are Associated with Greater Retinopathy Benefit\u2014A FIELD Trial Study"],"prefix":"10.2337","volume":"73","author":[{"given":"KWOK","family":"LEUNG ONG","sequence":"first","affiliation":[{"name":"Sydney, 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Despite anxiety and difficulty with executive cognitive skills being associated with autism, no studies to date have investigated relationships between anxiety or executive cognition with social and work functioning. This study aimed to investigate the associations between perceived social anxiety, perceived and objective executive function, and perceived social and work functioning in a sample of autistic people. A total of 62 participants completed self-report questionnaires of social anxiety (via the Liebowitz Social Anxiety Scale), mental health (via the Depression Anxiety Stress Scale), executive cognition (via the Behaviour Rating Inventory of Executive Function) and perceived social and work functioning (the Work and Social Adjustment Scale), and a smaller subset ( n = 36\u201340) completed performance-based executive function tasks (Trail Making Task and Rapid Visual Processing Task). Participants who reported having more social anxiety and more difficulty with executive cognition also perceived themselves as having poorer social and work functioning. Performance-based executive function was not related to social or work functioning. Our results suggest that perceived social anxiety and executive cognition are both areas that have potential to be targeted to investigate whether they improve social and vocational outcomes for autistic people.<\/jats:p>\n \n Lay abstract<\/jats:title>\n Many autistic adults have trouble in social situations and at work. Researchers do not know exactly why autistic people might find it difficult in these environments, and no studies to date have looked the way anxiety or other cognitive processes might affect autistic peoples\u2019 ability to socialise and succeed in getting and keeping jobs. Anxiety (how much you worry) and difficulty with getting stuff done or switching attention (known as executive function) can be concerns for autistic people and may contribute to social and work difficulties. This study looked at the relationships between the way autistic people perceived their anxiety and executive functioning and their ability to socialise and work. Sixty-two autistic participants completed questionnaires related to their ability to socialise and work, their social anxiety and their executive function. We found that participants who thought that they had poorer ability to work also found themselves to have more difficulties with executive function and they were more socially anxious. Our results showed that how autistic participants perceived their social anxiety and executive function were important in their perception of their social skills and work ability. This study supports the idea that anxiety and executive function could be targeted in interventions to support autistic people and their social and work outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/13623613211013664","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T02:58:26Z","timestamp":1626490706000},"page":"2124-2134","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Perceptions of social and work functioning are related to social anxiety and executive function in autistic adults"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3427-351X","authenticated-orcid":false,"given":"Alix","family":"Woolard","sequence":"first","affiliation":[{"name":"The University of Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0699-7588","authenticated-orcid":false,"given":"Elizabeth","family":"Stratton","sequence":"additional","affiliation":[{"name":"The University of Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni A","family":"Demetriou","sequence":"additional","affiliation":[{"name":"The University of Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9408-7367","authenticated-orcid":false,"given":"Kelsie A","family":"Boulton","sequence":"additional","affiliation":[{"name":"The University of Sydney, Australia"},{"name":"Neurodevelopment Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7246-8003","authenticated-orcid":false,"given":"Elizabeth","family":"Pellicano","sequence":"additional","affiliation":[{"name":"Neurodevelopment Australia, Australia"},{"name":"Macquarie University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Glozier","sequence":"additional","affiliation":[{"name":"The University of Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Gibbs","sequence":"additional","affiliation":[{"name":"The University of Sydney, Australia"},{"name":"Autism Spectrum Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Rogerson","sequence":"additional","affiliation":[{"name":"The University of Sydney, Australia"},{"name":"Neurodevelopment Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa","family":"Quinn","sequence":"additional","affiliation":[{"name":"The University of Sydney, Australia"},{"name":"Neurodevelopment Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian B","family":"Hickie","sequence":"additional","affiliation":[{"name":"The University of Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-4625","authenticated-orcid":false,"given":"Adam J","family":"Guastella","sequence":"additional","affiliation":[{"name":"The University of Sydney, Australia"},{"name":"Neurodevelopment Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"bibr1-13623613211013664","doi-asserted-by":"crossref","unstructured":"Alexander E. 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Collagenase clostridium histolyticum versus limited fasciectomy for Dupuytren\u2019s contracture: outcomes from a multicenter propensity score matched study. Plast Reconst Surg. 2015;136(1):87-97. https:\/\/journals.lww.com\/plasreconsurg\/fulltext\/2015\/07000\/collagenase_clostridium_histolyticum_versus.15.aspx","DOI":"10.1097\/PRS.0000000000001320"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"Kan HJ Selles RW van Nieuwenhoven CA et al. Percutaneous Aponeurotomy and Lipofilling (PALF) versus limited fasciectomy in patients with primary Dupuytren\u2019s contracture: a prospective randomized controlled trial. Plast Reconst Surg. 2016;137(6):1800-1812. https:\/\/journals.lww.com\/plasreconsurg\/fulltext\/2016\/06000\/percutaneous_aponeurotomy_and_lipofilling__palf_.28.aspx","DOI":"10.1097\/PRS.0000000000002224"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"Selles RW Zhou C Kan HJ et al. Percutaneous aponeurotomy and lipofilling versus limited fasciectomy for Dupuytren\u2019s contracture: 5-year results from a randomized clinical trial. Plast Reconst Surg. 2018;142(6):1523-1531. https:\/\/journals.lww.com\/plasreconsurg\/Fulltext\/2018\/12000\/Percutaneous_Aponeurotomy_and_Lipofilling_versus.26.aspx","DOI":"10.1097\/PRS.0000000000004982"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"}],"container-title":["HAND"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15589447231218397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15589447231218397","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15589447231218397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:29:07Z","timestamp":1777447747000},"score":7.611549,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15589447231218397"}},"issued":{"date-parts":[[2023,12,15]]},"references-count":6,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1177\/15589447231218397"],"URL":"https:\/\/doi.org\/10.1177\/15589447231218397","ISSN":["1558-9447","1558-9455"],"issn-type":[{"value":"1558-9447","type":"print"},{"value":"1558-9455","type":"electronic"}],"published":{"date-parts":[[2023,12,15]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:53:50Z","timestamp":1753876430946,"version":"3.41.2"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2023,5,24]]},"abstract":"Abstract<\/jats:title>\n \n Funding Acknowledgements<\/jats:title>\n Type of funding sources: Public Institution(s). Main funding source(s): Western Australian Department of Health.<\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n Chronic coronary heart disease (CCD) is associated with a high healthcare burden and expenditure in Western societies, yet population-level data on CCD are limited. Use of hospitalisation data to investigate CCD epidemiology has not been well explored. Our aim was to describe characteristics of patients hospitalised with CCD and to estimate the long-term risk of coronary outcomes in this cohort.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n We used Western Australian state-wide linked hospitalisation\/mortality data to identify all hospitalisations for CCD, comprised stable angina (SA, ICD-10-AM I20.1-I20.9) and chronic ischaemic heart disease (IHD, I25) from 2002 \u2013 2017. Index admissions were defined as the first SA or chronic IHD admission in the study period. 14-years of hospitalisation history data were used to identify prior medical history, including admissions for acute coronary syndromes (ACS) +\/- angiography, PCI and CABG. Kaplan-Meier survival analyses were used to estimate risk of readmission for coronary outcomes and procedures using up to 15-years of follow-up from linked morbidity\/mortality data.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n There were 32,557 index SA and 29,505 index chronic IHD admissions from 2002-2017. SA index case number declined by -3.9%\/year while chronic IHD admissions increased steadily (+5.3%\/year, age-adjusted). The mean age was 66 years for SA and chronic IHD index admissions, with women on average 3 years younger than men; median length of stay was 3 days. Women comprised a higher proportion of SA admissions (37.8%) than chronic IHD (26.9%, p&lt;0.0001). SA admissions were more likely to be emergency admissions (45.6% vs 13.4%) and have comorbidities including diabetes, hypertension and stroke. Patients with a chronic IHD admission were more likely to undergo angiography only (65.3% vs 46.7%) or revascularisation (20.6% vs 12.9%) during the index admission. Around 1\/3 of SA and chronic IHD patients had a prior ACS admission (n=9964 and 8291 respectively); around half of these prior ACS admissions occurred in the 1-year preceding the index SA and chronic IHD admissions (Figure), with the majority occurring in the 90 days immediately prior to the index admission. Following an index SA or chronic IHD admission, the risk of ACS within the initial year of follow-up was 9.4% in men and 8.6% in women with SA, and 5.6% in chronic IHD men and women. This risk increased to &gt;20% in both groups with 15 years of follow-up. The 15-year risk of CVD mortality was 4.3% in men and 4.2% in women following a chronic IHD admission; similar long-term risks were seen following SA admissions.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The heterogeneity in clinical profile and outcomes between patients admitted for SA versus chronic IHD requires cautious interpretation of hospitalisation data to inform the epidemiology of CCD. However, while mortality risk is low, the risk of ACS readmission is high, indicating significant ongoing morbidity and healthcare burden of CCD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwad125.179","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T10:42:49Z","timestamp":1684924969000},"source":"Crossref","is-referenced-by-count":0,"title":["Characteristics and risk of coronary-related events following hospitalisation for chronic coronary disease"],"prefix":"10.1093","volume":"30","author":[{"given":"L","family":"Nedkoff","sequence":"first","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Robinson","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hung","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F L","family":"Wright","sequence":"additional","affiliation":[{"name":"University of Oxford , Oxford , United Kingdom of Great Britain & Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Briffa","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P","family":"Chew","sequence":"additional","affiliation":[{"name":"Flinders MedicalCentre , Adelaide , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Herrington","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Katzenellenbogen","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Sohel","sequence":"additional","affiliation":[{"name":"Murdoch University , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Lopez","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Hickling","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Murray","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,24]]},"container-title":["European Journal of Preventive Cardiology"],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/30\/Supplement_1\/zwad125.179\/50458778\/zwad125.179.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjpc\/article-pdf\/30\/Supplement_1\/zwad125.179\/50458778\/zwad125.179.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T17:46:16Z","timestamp":1685123176000},"score":7.6114593,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjpc\/article\/doi\/10.1093\/eurjpc\/zwad125.179\/7175857"}},"issued":{"date-parts":[[2023,5,24]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2023,5,24]]},"published-print":{"date-parts":[[2023,5,24]]}},"URL":"https:\/\/doi.org\/10.1093\/eurjpc\/zwad125.179","ISSN":["2047-4873","2047-4881"],"issn-type":[{"type":"print","value":"2047-4873"},{"type":"electronic","value":"2047-4881"}],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2023,5,24]]},"article-number":"zwad125.179"},{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T10:02:44Z","timestamp":1780135364399,"version":"3.54.0"},"reference-count":70,"publisher":"SAGE 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This review sought to identify outcomes from home modifications for adults aged \u226550 years living in the community and their family carers. Peer-reviewed literature was reviewed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR). Five databases were search (Ageline, CINAHL, Emcare, Medline, Scopus) from 2011 to 2023.\n N<\/jats:italic>\n = 38 articles meeting the criteria. Sixteen outcomes were identified (14 positive, two negative) including reduction in falls and falls risk and enhanced quality of life. In addition, five outcomes for family carers were identified (all positive). Only four studies reported costs of home modifications installed. Home modifications can provide substantial benefit to adults aged \u226550 years, supporting their independence and allowing them to remain in their own home.\n <\/jats:p>","DOI":"10.1177\/15394492251361086","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T09:49:18Z","timestamp":1755337758000},"page":"539-554","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Home Modification Outcomes for Adults Aged 50 Years and Over and Their Relatives: A Scoping Review"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-8886","authenticated-orcid":false,"given":"Claire","family":"Hutchinson","sequence":"first","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Block","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Dymmott","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Gough","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Laver","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia"},{"name":"Southern Adelaide Local Health Network, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Walker","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Xiao","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"George","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia"},{"name":"Adelaide Primary Health Network, Torrensville Plaza, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,16]]},"reference":[{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-023-04279-1"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/02763893.2011.545735"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2022.2146765"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10901-022-09959-9"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1630.12156"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/1364557032000119616"},{"key":"e_1_3_3_9_1","unstructured":"Australian Bureau of Statistics. 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For instance, Electronic Health Records are usually administered by governments. Electronic Medical Records are typically controlled by health care providers, whereas Personal Health Records are managed directly by patients. Recently, Blockchain-based health record systems largely regulated by technology have emerged as another type of repository. Repositories for storing health data differ from one another based on cost, level of security and quality of performance. Not only has the type of repositories increased in recent years, but the quantum of health data to be stored has increased. For instance, the advent of wearable sensors that capture physiological signs has resulted in an exponential growth in digital health data. The increase in the types of repository and amount of data has driven a need for intelligent processes to select appropriate repositories as data is collected. However, the storage allocation decision is complex and nuanced. The challenges are exacerbated when health data are continuously streamed, as is the case with wearable sensors. Although patients are not always solely responsible for determining which repository should be used, they typically have some input into this decision. Patients can be expected to have idiosyncratic preferences regarding storage decisions depending on their unique contexts. In this paper, we propose a predictive model for the storage of health data that can meet patient needs and make storage decisions rapidly, in real-time, even with data streaming from wearable sensors. The model is built with a machine learning classifier that learns the mapping between characteristics of health data and features of storage repositories from a training set generated synthetically from correlations evident from small samples of experts. Results from the evaluation demonstrate the viability of the machine learning technique used.<\/jats:p>","DOI":"10.1177\/1460458220957486","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T05:24:10Z","timestamp":1600925050000},"page":"3009-3036","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Rapid health data repository allocation using predictive machine learning"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4316-4975","authenticated-orcid":false,"given":"Md Ashraf","family":"Uddin","sequence":"first","affiliation":[{"name":"Federation University Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Stranieri","sequence":"additional","affiliation":[{"name":"Federation University Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iqbal","family":"Gondal","sequence":"additional","affiliation":[{"name":"Federation University Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venki","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Federation University Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"bibr1-1460458220957486","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2018.10.006"},{"key":"bibr2-1460458220957486","volume-title":"Conceptualizing a data infrastructure for the capture, use, and sharing of patient-generated health data in care delivery and research through 2024 (white paper)","author":"Cortez A","year":"2018"},{"key":"bibr3-1460458220957486","first-page":"770","volume-title":"Proceedings of the 19th ACM conference on computer-supported cooperative work & social computing","author":"Chung CF"},{"key":"bibr4-1460458220957486","author":"Lordon RJ","journal-title":"Health Inform J"},{"key":"bibr5-1460458220957486","doi-asserted-by":"publisher","DOI":"10.1016\/j.outlook.2019.04.005"},{"key":"bibr6-1460458220957486","doi-asserted-by":"publisher","DOI":"10.4135\/9781452240121.n152"},{"key":"bibr7-1460458220957486","first-page":"159","volume":"40","author":"Bennett B","year":"2018","journal-title":"Sydney L Rev"},{"key":"bibr8-1460458220957486","doi-asserted-by":"publisher","DOI":"10.1080\/13600834.2019.1644068"},{"issue":"2","key":"bibr9-1460458220957486","first-page":"738","author":"Rantos K","year":"2018","journal-title":"ICETE"},{"key":"bibr10-1460458220957486","doi-asserted-by":"publisher","DOI":"10.1016\/j.im.2009.12.001"},{"key":"bibr11-1460458220957486","first-page":"1","volume-title":"2018 IEEE 20th international conference on e-health networking, applications and services (Healthcom)","author":"Zheng X"},{"key":"bibr12-1460458220957486","doi-asserted-by":"publisher","DOI":"10.1007\/s10916-018-0983-9"},{"key":"bibr13-1460458220957486","doi-asserted-by":"publisher","DOI":"10.1007\/s10916-015-0376-2"},{"key":"bibr14-1460458220957486","doi-asserted-by":"publisher","DOI":"10.1016\/j.procs.2013.06.014"},{"key":"bibr15-1460458220957486","unstructured":"Record MH. 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Weka: practical machine learning tools and techniques with java implementations (Working paper 99\/11). Hamilton, New Zealand: University of Waikato, 1999."},{"key":"bibr80-1460458220957486","doi-asserted-by":"publisher","DOI":"10.3390\/electronics9010173"}],"container-title":["Health Informatics Journal"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1460458220957486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1460458220957486","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1460458220957486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:31:14Z","timestamp":1777501874000},"score":7.611335,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1460458220957486"}},"issued":{"date-parts":[[2020,9,24]]},"references-count":80,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1177\/1460458220957486"],"URL":"https:\/\/doi.org\/10.1177\/1460458220957486","ISSN":["1460-4582","1741-2811"],"issn-type":[{"value":"1460-4582","type":"print"},{"value":"1741-2811","type":"electronic"}],"published":{"date-parts":[[2020,9,24]]}},{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:02:02Z","timestamp":1770984122655,"version":"3.50.1"},"reference-count":0,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"16_suppl","funder":[{"DOI":"10.13039\/100020193","name":"Novartis Australia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100020193","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2024,6,1]]},"abstract":" e18519 <\/jats:p> Background: Despite advances in the management of chronic myeloid leukemia (CML), effective treatment options in later lines are limited. Treatment failure rates increase with each line of treatment and sequential tyrosine kinase inhibitor (TKI) therapy is associated with increased resistance. Importantly, almost all TKIs in the clinics target the ATP-binding site potentially resulting in off-target effects and long-term tolerability issues. Although data for ASC, a novel allosteric TKI targeting the myristoyl pocket, is emerging in the RW setting, low patient numbers in ASC RW studies hinders a robust comparison with the larger phase 3 RCT study. Methods: Post systematic literature search, data from 9 published or publicly presented RW studies was extracted. 319 CML patients that received ASC beyond 2 TKIs were included in this analysis. RW studies that had less than 10 patients were excluded. The results were then compared to estimates from the ASCEMBL study. Results: Compared to the RCT, RW studies showed similar or higher efficacy based on major molecular response (MMR) and deep molecular response (DMR) rates, achieved in shorter time. Rate of discontinuation of ASC was also lower in the RW setting. Similarly, some adverse events, specifically thrombocytopenia and arterial occlusive events (AOE) were lower, while some such as myalgia were higher in the RW setting when compared with the RCT. Conclusions: This analysis demonstrates ASC as an effective TKI for CML patients in the RW setting, supporting the results from the ASCEMBL RCT. [Table: see text] <\/jats:p>","DOI":"10.1200\/jco.2024.42.16_suppl.e18519","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T16:59:22Z","timestamp":1718038762000},"page":"e18519-e18519","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["ASC4REAL: Efficacy and tolerability comparison between ASCEMBL study, a phase 3 randomized clinical trial (RCT), and consolidated real-world (RW) experience with asciminib (ASC) in patients with CML beyond two TKIs."],"prefix":"10.1200","volume":"42","author":[{"given":"Anchit","family":"Khanna","sequence":"first","affiliation":[{"name":"Novartis Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Small","sequence":"additional","affiliation":[{"name":"Novartis Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhamend","family":"Lutchman","sequence":"additional","affiliation":[{"name":"Novartis Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Schofield","sequence":"additional","affiliation":[{"name":"Novartis Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","container-title":["Journal of Clinical Oncology"],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2024.42.16_suppl.e18519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T17:00:37Z","timestamp":1718038837000},"score":7.611335,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2024.42.16_suppl.e18519"}},"issued":{"date-parts":[[2024,6,1]]},"references-count":0,"journal-issue":{"issue":"16_suppl","published-print":{"date-parts":[[2024,6,1]]}},"alternative-id":["10.1200\/JCO.2024.42.16_suppl.e18519"],"URL":"https:\/\/doi.org\/10.1200\/jco.2024.42.16_suppl.e18519","ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"published":{"date-parts":[[2024,6,1]]},"assertion":[{"value":"2024-05-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:53:26Z","timestamp":1773215606107,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006065","name":"Department of Health, Government of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1173896"],"award-info":[{"award-number":["1173896"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCPP Advances"],"published-print":{"date-parts":[[2026,3]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Young children diagnosed with autism experience high rates of co\u2010occurring anxiety, with uncertainty\u2010related concerns commonly reported. This randomized controlled trial investigated an 8\u2010week parent\u2010mediated group anxiety intervention, \u201cCoping with Uncertainty in Everyday Situations\u201d (CUES\u2010Junior\u00a9).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Parents of 4\u20137\u2010year\u2010old children diagnosed with autism and experiencing uncertainty\u2010related anxiety were recruited. The primary outcome was change from baseline in blinded assessor ratings of child responses to uncertainty and impact on family, measured post\u2010intervention and 2\u2010month follow\u2010up. Secondary outcomes were parent\u2010reported child anxiety and intolerance of uncertainty (IU), parental IU and mental health, parenting sense of competence, along with intervention feasibility and acceptability.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Sixty\u2010four children were randomized to CUES\u2010Junior\u00a9 (\n n<\/jats:italic>\n \u00a0=\u00a033) or waitlist (\n n<\/jats:italic>\n \u00a0=\u00a031); five families withdrew post\u2010randomization. Immediately post\u2010intervention, significantly more CUES\u2010Junior\u00a9 participants were rated as clinically improved from baseline in child responses to uncertainty (OR\u00a0=\u00a034.48; 95% CI\u00a0=\u00a01.72\u2013690.04,\n p<\/jats:italic>\n \u00a0=\u00a00.02) and in family impact (OR\u00a0=\u00a08.99; 95% CI\u00a0=\u00a01.52\u201353.05,\n p<\/jats:italic>\n \u00a0=\u00a00.02) compared to waitlist. Significant improvements were also observed in parent\u2010reported child IU and parenting satisfaction, favoring CUES\u2010Junior\u00a9. At subsequent 2\u2010month follow\u2010up, CUES\u2010Junior\u00a9 participants showed sustained improvements in the impact of uncertainty on children, and parental ratings of child IU and anxiety, parenting sense of competence, and parental stress, compared to baseline. The program was feasible to administer and acceptable to parents.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n CUES\u2010Junior\u00a9 had an immediate treatment effect on child responses to uncertain situations and impact on families, with maintained improvements observed at follow\u2010up. This novel mechanism\u2010targeted and autism\u2010informed program holds promise for addressing early uncertainty\u2010related anxiety in young children diagnosed with autism.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcv2.70027","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T12:00:10Z","timestamp":1750939210000},"source":"Crossref","is-referenced-by-count":1,"title":["Targeting intolerance of uncertainty in young children diagnosed with autism: A randomized controlled trial of a parent\u2010mediated group intervention"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8980-642X","authenticated-orcid":false,"given":"Claudia S. 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A mixed-methods approach was employed, surveying 272 Australian participants, including 136 Autistic adults, 128 parents or caregivers of Autistic children and eight Autistic children. Our research aimed to understand who is using the alert card, in what contexts and the differences in perceptions of the card between Autistic individuals and their parents. Findings indicate that about half of the participants used the card, primarily in public settings such as transport (17%), healthcare (16%) and retail (16%). The card was seen as a valuable tool for facilitating communication, reducing the need for verbal explanations and providing a sense of security. However, challenges were reported, including societal disbelief, patronising attitudes and internalised stigma, highlighting the need for greater public education on autism. Despite these challenges, majority of participants (76.2%) would recommend the card. This research underscores the dual nature of autism alert cards as both beneficial and limited by societal attitudes, emphasising the need for comprehensive training and awareness programmes to maximise their effectiveness.<\/jats:p>\n \n Lay abstract<\/jats:title>\n This study looks at how people use and feel about autism alert cards, which help Autistic people communicate their diagnosis\/identity. We surveyed 272 Australian people, including 136 Autistic adults, 128 parents of Autistic children and eight Autistic children. About half of the participants used the card after ordering it, mostly in public places such as public transport, healthcare settings and in retail settings. People found the card helpful because it made it easier to explain their needs without having to speak and provided them a sense of security. However, some people treated Autistic people poorly after being shown the card due to a lack of understanding about autism. Many participants felt that more education about autism is needed to improve how people react to the alert card. Despite these challenges, most participants (76.2%) would recommend the alert card to others. This research shows that while autism alert cards can be very helpful, their effectiveness depends on how well other people understand and accept autism. 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Retrieved September 27, 2022, from https:\/\/journals.lww.com\/thehearingjournal\/blog\/onlinefirst\/pages\/post.aspx?PostID=71","journal-title":"The Hearing Journal"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2020.1814432"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2005.01.0001"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/14992027.2014.921736"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.2196\/17298"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/15459624.2011.559417"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/14992020903470783"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1044\/2018_JSLHR-H-16-0397"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2020.1805804"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6815-12-12"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2021.1897169"}],"container-title":["International Journal of Audiology"],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14992027.2022.2128446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:02:35Z","timestamp":1701388955000},"score":7.610847,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14992027.2022.2128446"}},"issued":{"date-parts":[[2022,10,4]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1080\/14992027.2022.2128446"],"URL":"https:\/\/doi.org\/10.1080\/14992027.2022.2128446","ISSN":["1499-2027","1708-8186"],"issn-type":[{"value":"1499-2027","type":"print"},{"value":"1708-8186","type":"electronic"}],"published":{"date-parts":[[2022,10,4]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iija20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iija20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:34:02Z","timestamp":1783953242211,"version":"3.55.0"},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Summary<\/jats:title>Screening and treatment for hepatitis C virus (HCV<\/jats:styled-content>) infection were not prioritised in psychiatric patients due to adverse neuropsychiatric effects of interferon therapy despite reports of high prevalence. However, with the safe new antiviral drugs, HCV<\/jats:styled-content> eradication has become a reality in these patients. The aim of this study was to report HCV<\/jats:styled-content> seroprevalence, risk factors and treatment model in an Australian cohort. This prospective study involved patients admitted to four inpatient psychiatric units, from December 2016 to December 2017. After pretest counselling and consent, HCV<\/jats:styled-content> testing was done; information on risk factors collected. A total of 260 patients (70% male), median age 44\u00a0years (IQR<\/jats:styled-content> 24), were studied. The HCV<\/jats:styled-content> seroprevalence was 10.8% (28\/260) with 95% CI<\/jats:styled-content> 7\u201015. Independent predictors of HCV<\/jats:styled-content> positivity were injection drug use (P<\/jats:italic>\u00a0<\u00a00.001, OR<\/jats:styled-content> 44.05, 95% CI<\/jats:styled-content> 7.9\u2010245.5), exposure to custodial stay (P<\/jats:italic>\u00a0=\u00a00.011, OR<\/jats:styled-content> 7.34, 95% CI<\/jats:styled-content> 1.6\u201033.9) and age (P<\/jats:italic>\u00a0=\u00a00.011, OR<\/jats:styled-content> 1.09, 95% CI<\/jats:styled-content> 1.02\u20101.16). Eight of the 16 HCV RNA<\/jats:styled-content>\u2010positive patients were treated. Hepatitis nurses liaised with community mental health teams for treatment initiation and follow\u2010up under supervision of hepatologists. Seven patients achieved sustained viral response, one achieved end of treatment response. The remaining eight patients were difficult to engage with. In conclusion, HCV<\/jats:styled-content> prevalence was high in our cohort of psychiatric inpatients. Although treatment uptake was achieved only in 50% patients, it was successfully completed in all, with innovative models of care. These findings highlight the need to integrate HCV<\/jats:styled-content> screening with treatment linkage in psychiatry practice.<\/jats:p>","DOI":"10.1111\/jvh.13056","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T22:05:09Z","timestamp":1545429909000},"page":"609-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Hepatitis C virus infection in Australian psychiatric inpatients: A multicenter study of seroprevalence, risk factors and treatment experience"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2505-9274","authenticated-orcid":false,"given":"Jeyamani","family":"Ramachandran","sequence":"first","affiliation":[{"name":"Hepatology and Liver Transplantation Unit Flinders Medical Centre Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia 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Flinders Medical Centre Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00357-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2016.303059"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-018-1735-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.07.027"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10398560701358113"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/10398561003763273"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.08.080"}],"container-title":["Journal of Viral Hepatitis"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvh.13056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvh.13056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.13056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T18:57:12Z","timestamp":1694372232000},"score":7.6106334,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.13056"}},"issued":{"date-parts":[[2019,1,16]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/jvh.13056"],"URL":"https:\/\/doi.org\/10.1111\/jvh.13056","archive":["Portico"],"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"published":{"date-parts":[[2019,1,16]]},"assertion":[{"value":"2018-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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in at\u2010risk surgical populations. We sought to determine if melatonin use reduces the incidence of delirium in individuals undergoing major cardiac surgery.<\/jats:p>\n <\/jats:sec>\n \n DESIGN<\/jats:title>\n Randomized double\u2010blind placebo\u2010controlled clinical trial (two arms, 1:1 allocation, parallel design).<\/jats:p>\n <\/jats:sec>\n \n SETTING<\/jats:title>\n The trial took place in two metropolitan hospitals (public tertiary and private) in Perth, Western Australia.<\/jats:p>\n <\/jats:sec>\n \n PARTICIPANTS<\/jats:title>\n We recruited 210 adults aged 50\u2009years or older who were due to undergo coronary artery bypass grafting or valve replacement surgery.<\/jats:p>\n <\/jats:sec>\n \n INTERVENTION<\/jats:title>\n Participants were randomly assigned (1:1) to 7\u2009days of treatment with melatonin 3 mg at night or matching placebo, starting 2\u2009days before the surgery.<\/jats:p>\n <\/jats:sec>\n \n MEASUREMENTS<\/jats:title>\n The primary outcome of interest was incident delirium within 7\u2009days of surgery as assessed via daily clinical assessment that included the Confusion Assessment Method. Secondary outcomes of interest included duration and severity of delirium, length of hospital stay, cognitive function, and mood and anxiety symptoms at discharge and 3 months after the surgery.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n The groups were well balanced for demographic and clinical parameters. Forty\u2010two participants developed delirium, but it was evenly distributed between the groups (melatonin 21\/98, 21.4%; placebo 21\/104, 20.2%; adjusted odds ratio [OR] = .78; 95% confidence interval [CI] = .35\u20101.75). The median duration of delirium was 3 (interquartile range [IQR] = 2\u20104) and 2 (IQR = 1\u20103) days for people treated with melatonin and placebo, respectively (\n z<\/jats:italic>\n = \u22121.03;\n P<\/jats:italic>\n = .304). A similar proportion of participants experienced severe episodes of delirium in each group (melatonin 9\/21, 42.9% vs placebo 6\/21, 28.6%; \u03c7\n 2<\/jats:sup>\n = .93;\n P<\/jats:italic>\n = .334; adjusted OR = 1.98; 95% CI = .40\u20109.78). The groups did not differ in terms of length of stay, mood, anxiety, and cognitive performance.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n The findings of this randomized double\u2010blind placebo\u2010controlled trial do not support the prophylactic use of melatonin to prevent delirium after major cardiac surgery.\n J Am Geriatr Soc 68:112\u2013119, 2019<\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.16162","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T01:01:22Z","timestamp":1570582882000},"page":"112-119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["The Healthy Heart\u2010Mind Trial: Randomized Controlled Trial of Melatonin for Prevention of Delirium"],"prefix":"10.1111","volume":"68","author":[{"given":"Andrew H.","family":"Ford","sequence":"first","affiliation":[{"name":"Medical School University of Western Australia Perth Western Australia Australia"},{"name":"WA Centre for Health & Ageing University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Flicker","sequence":"additional","affiliation":[{"name":"Medical School University of Western Australia Perth Western Australia Australia"},{"name":"WA Centre for Health & Ageing University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Kelly","sequence":"additional","affiliation":[{"name":"Medical School University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hema","family":"Patel","sequence":"additional","affiliation":[{"name":"Medical School University of Western Australia Perth Western Australia 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disjoint cliques in graphs","volume":"60","author":"Gyori","year":"1992","journal-title":"Sets, graphs and numbers"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1051\/ro\/1997310100451"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1137\/130933800"},{"key":"ref25","article-title":"Preparation of a real temporal voter data set for record linkage and duplicate detection research","author":"Christen","year":"2014","journal-title":"The Australian National University, Tech. Rep."},{"key":"ref26","volume-title":"Record linkage methods with applications to causal inference and election voting data","author":"Wortman","year":"2019"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0283811"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1109\/IEEECONF44664.2019.9048653"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1142\/S0218126619500658"}],"event":{"name":"2025 IEEE International Conference on Big Data (BigData)","location":"Macau, China","start":{"date-parts":[[2025,12,8]]},"end":{"date-parts":[[2025,12,11]]}},"container-title":["2025 IEEE International Conference on Big Data (BigData)"],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/11400704\/11400712\/11400814.pdf?arnumber=11400814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T07:26:54Z","timestamp":1772868414000},"score":7.610167,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11400814\/"}},"issued":{"date-parts":[[2025,12,8]]},"references-count":29,"URL":"https:\/\/doi.org\/10.1109\/bigdata66926.2025.11400814","published":{"date-parts":[[2025,12,8]]}},{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:01:54Z","timestamp":1769824914498,"version":"3.49.0"},"reference-count":0,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"16_suppl","funder":[{"name":"Western Australian Cancer and Palliative Care Network Fellowship Grant"}],"content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2023,6,1]]},"abstract":" e18008 <\/jats:p> Background: Social demographics and health inequalities are associated with adverse outcomes in cancer. Methods: We conducted a retrospective review of 320 Head and Neck Cancer patients between 2013-2021 in a tertiary centre in Western Australia. We matched 80 Aboriginal patients with 240 non-Aboriginal patients by disease site, histology, age, and rurality. Data collected included tumour site, patient demographics, treatments, recurrences, and survival outcomes. An initial univariate analysis was performed using Chi-Square and Kaplan Meier analyses; however a multivariate analysis will be conducted for subsequent publication. Results: Median follow-up was 2.6 years (range 16 days to 9 years). 44% of patients underwent curative intent radiotherapy or chemoradiotherapy, 38% had surgery (+\/- adjuvant therapies), 9% had palliative treatments, and 9% had best supportive care. Overall survival (OS) using Kaplan-Meier was inferior for Aboriginal patients compared with non-Aboriginal patients; 1 year survival (YS) 59% vs 85% and 5YS 32% vs 60% (p < 0.00001). Of patients receiving curative intent treatment, relapse occurred in 47% of Aboriginal patients compared with 29% of non-Aboriginal patients (p = 0.01), with inferior progression-free survival (PFS) 1 yr PFS 71% vs 81% and 5yr PFS 52% vs 72%, p = 0.006. 2YS was highest in regional patients (77%), followed by metropolitan (68%), and lowest in remote patients (61%), p = 0.04. 21% of remote patients opted for palliative treatment despite curative treatment being recommended, compared with 3% of regional and 4% of metropolitan patients. Amongst patients receiving curative treatment (81%), metropolitan patients had the highest risk of relapse (42%), compared with remote (31%) and regional (23%), p = 0.02. Despite this, in the same group of treated patients, remote patients had the lowest survival (2YS 88% regional, 80% metropolitan, 75% remote, p = 0.04). Ever smokers had lower 1YS (91% vs 76%, p = 0.03), a higher risk of relapse (28% vs 21%, p = 0.01), and a lower likelihood of disease-free survival (53% vs 74%, p = 0.01) compared to never smokers. Alcohol excess was associated with inferior 1YS (84% 0-4 std\/d, 85% 5-10 std\/d, 57% > 10 std\/d, p = 0.00004), and a higher risk of relapse (19% for non-drinkers, 35% 1-4 std\/d, 27% 5-10 std\/d, and 64% for > 10 std\/d, p = 0.00007). Marital stability was associated with improved 1YS (88% married, 78% widowed, 78% de facto, 76% divorced, 65% single, p = 0.004). Single patients had the lowest likelihood of disease-free survival (42%), followed by divorced (50%), de facto (50%), and widowed (65%). Married patients had the best disease-free survival (66%), p = 0.002. Non-English speaking status was associated with inferior 1YS (79% vs 40%, p = 0.006). Conclusions: Aboriginal status, rurality, smoking, high alcohol consumption, single or divorced individuals, and non-English speaking were all associated with poorer outcomes. <\/jats:p>","DOI":"10.1200\/jco.2023.41.16_suppl.e18008","type":"journal-article","created":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T16:00:42Z","timestamp":1685894442000},"page":"e18008-e18008","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Social determinants of survival in head and neck cancer."],"prefix":"10.1200","volume":"41","author":[{"given":"Kim Robyn","family":"Kennedy","sequence":"first","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daren Joseph","family":"Gibson","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Flukes","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa Jane","family":"Spalding","sequence":"additional","affiliation":[{"name":"University of Western Australia, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra Sai","family":"Diwakarla","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew David","family":"Redfern","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","container-title":["Journal of Clinical Oncology"],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2023.41.16_suppl.e18008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T16:03:17Z","timestamp":1685894597000},"score":7.6099606,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2023.41.16_suppl.e18008"}},"issued":{"date-parts":[[2023,6,1]]},"references-count":0,"journal-issue":{"issue":"16_suppl","published-print":{"date-parts":[[2023,6,1]]}},"alternative-id":["10.1200\/JCO.2023.41.16_suppl.e18008"],"URL":"https:\/\/doi.org\/10.1200\/jco.2023.41.16_suppl.e18008","ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"published":{"date-parts":[[2023,6,1]]},"assertion":[{"value":"2023-05-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T06:14:02Z","timestamp":1651212842057},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.juro.2017.02.1661","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T18:32:10Z","timestamp":1491244330000},"source":"Crossref","is-referenced-by-count":0,"title":["MP53-10 ROBOT-ASSISTED SALVAGE NODE DISSECTION FOR OLIGOMETASTATIC NODAL DISEASE DETECTED BY 68GALLIUM-PSMA PET\/CT: A MULTICENTRE RETROSPECTIVE SERIES"],"prefix":"10.1097","volume":"197","author":[{"given":"Amila","family":"Siriwardana","sequence":"first","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Thompson","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaela","family":"Doig","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pim","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Kalsbeek","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Emmett","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warick","family":"Delprado","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemamali","family":"Samaratunga","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Maree","family":"Haynes","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"Coughlin","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Stricker","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534717331270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534717331270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2017.02.1661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:52:54Z","timestamp":1651211574000},"score":7.609833,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2017.02.1661"}},"issued":{"date-parts":[[2017,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1016\/j.juro.2017.02.1661"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2017.02.1661","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2017,4]]}},{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:13:23Z","timestamp":1773004403073,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Increased breast density is associated with increased breast cancer risk, particularly interval\u2010detected cancers. This study describes interval cancer detection rates by breast density notification status and timing of diagnosis (0\u201312\u2009months vs. 13\u201324\u2009months).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n 401,254 screening records for 235,333 clients attending a population\u2010based screening program in 2016\u20132019 were extracted from the BreastScreen Western Australia database. Crude and age\u2010standardised interval cancer rates (ASR), aggregated over three\u2010year periods, were calculated per 10,000 client\u2010years and reported by breast density notification status, screening round, and timing of diagnoses.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Overall, interval cancer rates were 2\u20136 times higher in clients notified they had dense breasts compared to those who were not flagged as having dense breasts. The 2016\u20132018 ASRs were higher in the first year (vs second year) for clients notified they had dense breasts (ASRs: 28.2 (95% CI: 12.9\u201366.0) vs 20.6 (95% CI: 13.2\u201355.8) per 10,000 client\u2010years, respectively), particularly notified clients screening for the first time (ASRs: 32.7 (95% CI: 6.9\u2013111.2) vs 18.2 (95% CI: 5.9\u201392.0), respectively). The corresponding rates for 2017\u20132019 showed a similar trend but of lesser magnitude (ASRs: 17.6 (95% CI: 12.9\u201334.2) vs 15.7 (95% CI: 11.0\u201335.5) for 0\u201312 vs 13\u201324\u2009months, respectively), regardless of screening round.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Interval cancer rates were at least similar or higher in the first 12\u2009months compared to 13\u201324\u2009months post screening for clients notified they had dense breasts, contrary to national reports of interval cancer detection rates. The clinical implications are two\u2010fold: performance metrics for screening programs that notify women of their breast density may need refinement, namely interval cancer rate targets within 0\u201312\u2009months, and breast density notification could lead to earlier diagnoses of interval\u2010detected breast cancers.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1754-9485.70067","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T13:08:11Z","timestamp":1769000891000},"page":"169-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Breast Density Notification on Interval Cancer Rates"],"prefix":"10.1111","volume":"70","author":[{"given":"Jennifer","family":"Stone","sequence":"first","affiliation":[{"name":"School of Population and Global Health, University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Marriott","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Orellana","sequence":"additional","affiliation":[{"name":"BreastScreen Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmeline","family":"Lee","sequence":"additional","affiliation":[{"name":"BreastScreen Western Australia Perth Western Australia Australia"},{"name":"Sir Charles Gardiner Hospital Perth Western Australia Australia"},{"name":"King Edward Memorial Hospital Perth Western Australia Australia"},{"name":"Medical School, University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth","family":"Porter","sequence":"additional","affiliation":[{"name":"BreastScreen Western Australia Perth Western Australia Australia"},{"name":"Sir Charles Gardiner Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-17-1175"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0034"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062790"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.7227"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab016"},{"key":"e_1_2_10_8_1","unstructured":"BreastScreen Australia \u201cBreastScreen Australia\u2014Position Statement on Breast Density and Screening \u201dhttps:\/\/www.health.gov.au\/resources\/publications\/breastscreen\u2010australia\u2010position\u2010statement\u2010on\u2010breast\u2010density\u2010and\u2010screening?language=en2025."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903986"},{"key":"e_1_2_10_10_1","unstructured":"Australia B \u201cBreast Density GP Guidance \u201dhttps:\/\/www.health.gov.au\/our\u2010work\/breastscreen\u2010australia\u2010program\/health\u2010professionals\/breast\u2010density\u2010information\u2010for\u2010gps2025."},{"issue":"2","key":"e_1_2_10_11_1","first-page":"29","article-title":"What Do Women Do After Being Told They Have Dense Breasts?","volume":"32","author":"Darcey E.","year":"2020","journal-title":"Health Promotion Journal of Australia"},{"key":"e_1_2_10_12_1","unstructured":"Australian Institute of Health and Welfare \u201cBreastScreen Australia Monitoring Report 2023 \u201d(2023)."},{"key":"e_1_2_10_13_1","volume-title":"RANZCR Breast Imaging Group (BIG) General Meeting Abstracts. RANZCR Breast Imaging Group (BIG) General Meeting","author":"Royal Australian New Zealand College of Radiologists","year":"2025"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19970415)16:7<791::AID-SIM500>3.0.CO;2-#"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1258\/096914106778440572"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anzjph.2025.100240"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6883"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.70067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1754-9485.70067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.70067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:36:20Z","timestamp":1772994980000},"score":7.609314,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.70067"}},"issued":{"date-parts":[[2026,1,21]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/1754-9485.70067"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.70067","archive":["Portico"],"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"published":{"date-parts":[[2026,1,21]]},"assertion":[{"value":"2025-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:00Z","timestamp":1753889760159,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Introduction: Multimorbidity (MM) is common in people with T2D (PwT2D) who in Australia, receive medical care predominantly in family practice (FP). We explored the association between MM condition count and HbA1c in PwT2D attending Australian FP, using electronic health record (EHR) data.<\/jats:p>\n Methods: Cross-sectional study of 69,718 PwT2D who had a FP encounter between 2013-15 captured in the NPS MedicineInsight dataset (EHR data from &gt;500 family practices and 3.5 million patients across Australia). MM condition count was based on coded and free text conditions in the reason for visit, prescription or medical history fields. Primary outcome: HbA1c. Multivariable mixed-effects linear regression examined associations between MM counts (total, concordant (T2D-related) and discordant (unrelated)) and HbA1c (%).<\/jats:p>\n Results: We found statistically significant associations between HbA1c and total and discordant MM counts. Mean HbA1c (95% CI) was lower for those having 1, 2, 3 and 4+ total conditions compared to T2D only, -0.065 (-0.089, -0.041), -0.097 (-0.128, -0.066), -0.089 (-0.133, -0.046), and -0.097 (-0.146, -0.047) respectively, and for discordant conditions -0.085 (-0.108, -0.061), -0.100 (-0.134, -0.065), -0.141 (-0.195, -0.087), and -0.204 (-0.276, -0.133). There was no statistically significant association between HbA1c and increasing concordant count.<\/jats:p>\n Conclusions: While EHR counts of MM and discordant conditions are associated with lower HbA1c, this is not likely to be clinically significant, suggesting the impact of MM on HbA1c remains unclear. The NPS dataset uses routine data entered by clinicians for the purpose of patient care, rather than epidemiological studies and may thus underestimate the number of conditions experienced by PwT2D. While clinicians need to consider the MM burden of PwT2D, the NPS MedicineInsight dataset needs further validation, eg through combining with other data sources, in the study of MM.<\/jats:p>\n \n Disclosure<\/jats:title>\n J.I. Chiang: None. J. Furler: Research Support; Self; Abbott, Sanofi. B.D. Jani: None. F.S. Mair: None. S. Thuraisingam: None. B.I. Nicholl: None. J.E. Manski-Nankervis: Research Support; Self; Australian National Health and Medical Research Council, Boehringer Ingelheim International GmbH, Diabetes Australia, Eli Lilly and Company. Speaker\u2019s Bureau; Self; RACGP.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Royal Australian College of General Practitioners<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-217-lb","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T02:12:33Z","timestamp":1559700753000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["217-LB: Associations between Multimorbidity and HbA1c in People with Type 2 Diabetes in Australian Family Practice"],"prefix":"10.2337","volume":"68","author":[{"given":"JASON I.","family":"CHIANG","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Glasgow, United Kingdom, Carlton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN","family":"FURLER","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Glasgow, United Kingdom, Carlton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BHAUTESH D.","family":"JANI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Glasgow, United Kingdom, Carlton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FRANCES S.","family":"MAIR","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Glasgow, United Kingdom, Carlton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHARMALA","family":"THURAISINGAM","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Glasgow, United Kingdom, Carlton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BARBARA I.","family":"NICHOLL","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Glasgow, United Kingdom, Carlton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JO-ANNE E.","family":"MANSKI-NANKERVIS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Glasgow, United Kingdom, Carlton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/217-LB\/60102\/217-LB-Associations-between-Multimorbidity-and","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/217-LB\/60102\/217-LB-Associations-between-Multimorbidity-and","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:23:29Z","timestamp":1647167009000},"score":7.6092315,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/217-LB\/60102\/217-LB-Associations-between-Multimorbidity-and"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-217-lb","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"217-LB"},{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:46:04Z","timestamp":1760647564025,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2022,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Total hip arthroplasty (THA) is common though the investigation of new prostheses requires a practical, step\u2010wise introduction. This study reports the 2\u2010year clinical results and periprosthetic bone mineral density (BMD) changes, along with a subset undergoing Radiostereometric analysis (RSA), in patients undergoing primary cemented THA using a new highly polished, double tapered, collarless femoral stem (Absolut).<\/jats:p><\/jats:sec>Methods<\/jats:title>Between August 2013 and December 2016, 47 patients with a mean age of 74.2\u2009years (range 36\u201389) underwent 51 THAs with the Absolut. All patients underwent clinical assessment pre\u2010surgery and at 6\u2009weeks, 3, 12 and 24\u2009months using the Oxford and Harris Hip Scores, as well as Dual Energy X\u2010ray Absorptiometry (DEXA) to assess BMD within 2\u20134\u2009weeks post\u2010surgery, 12 and 24\u2009months. RSA was undertaken in a patient subset (the first n<\/jats:italic>\u00a0=\u200930) early post\u2010surgery (1\u20132\u2009days) and 3, 12 and 24\u2009months.<\/jats:p><\/jats:sec>Results<\/jats:title>All clinical scores significantly improved (p<\/jats:italic>\u00a0<\u20090.05). RSA revealed a mean subsidence of 0.78\u2009mm at 3\u00a0months, 1.23\u2009mm at 12\u2009months and 1.51\u2009mm at 24\u2009months. Anterior\u2013posterior and medial\u2010lateral translation was negligible. A significant increase (p<\/jats:italic>\u00a0=\u20090.020) in BMD was observed in Gruen zone 1, though no significant changes were observed for any other zone up until 2\u2009years. Two patients acquired an early post\u2010operative deep vein thrombosis that were treated accordingly and resolved, with no further complications or re\u2010operations.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The Absolut cemented femoral stem demonstrated good outcomes, BMD changes consistent with sound prosthesis integration and patterns of post\u2010operative micromotion observed in other successful cemented stems.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.17519","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T09:39:20Z","timestamp":1643794760000},"page":"830-836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A 2\u2010year prospective clinical and bone density evaluation, with a subset undergoing radiostereometric analysis, using the Absolut cemented stem"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5843-6243","authenticated-orcid":false,"given":"Jay R.","family":"Ebert","sequence":"first","affiliation":[{"name":"School of Human Sciences (Exercise and Sport Science) University of Western Australia Perth Western Australia Australia"},{"name":"HFRC Perth Western Australia Australia"},{"name":"Orthopaedic Research Foundation of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils O.","family":"Nivbrant","sequence":"additional","affiliation":[{"name":"Perth Orthopaedic Institute Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Petrov","sequence":"additional","affiliation":[{"name":"HFRC Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piers","family":"Yates","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Foundation of Western Australia Perth Western Australia Australia"},{"name":"Fremantle Hospital Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Wood","sequence":"additional","affiliation":[{"name":"Perth Orthopaedic Institute Perth Western Australia Australia"},{"name":"School of Surgery (Orthopaedics) University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(97)90194-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.80B5.8621"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.88B12.18345"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-007-0049-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.91B6.21627"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2009.02.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.81B1.8904"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016470410001169-1"},{"key":"e_1_2_9_10_1","first-page":"94","article-title":"Radiostereometry of hip prostheses. Review of methodology and clinical results","volume":"344","author":"Karrholm J","year":"1997","journal-title":"Clin. Orthop. Relat. 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Orthop. Relat. 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However, modern cultivars have undergone a substantial loss of genetic diversity due to intensive breeding. A pool of genetic diversity remains untapped in wheat landraces, and pangenomics can help identify genes of potential agronomic importance in these old lines that can be applied to accelerate wheat improvement. Here, we have constructed the largest wheat pangenome to date, representing 1,061 diverse individuals (827 landraces and 234 modern cultivars) from 47 countries across six continents. We identified 10,426 predicted gene models specific to landraces that are enriched for functions associated with disease resistance, abiotic stress adaptation, and symbiosis. 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Cases were identified from medical records, and women telephoned to assess adverse outcomes, procedure tolerability and confirm pregnancy outcomes within six\u00a0months from procedure.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 325 cases were identified; 14 were excluded due to incomplete or abandoned procedure, 32 were lost to follow\u2010up, leaving 279 for analysis. Fourteen women (5% overall) experienced mild vasovagal reactions, with one case of infection and no reports of anaphylaxis or allergy. There were 141 conceptions reported (51%) within six\u00a0months after Lipiodol flush, and an ongoing pregnancy in 43% (119) of women. For women with ongoing pregnancies, 55% (78\/119) conceived spontaneously, and 45% (63\/119) via artificial reproductive technology. Mean recalled pain score was 5.7 (SD 3.2; range 0\u201010) at a single site.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This Phase 1 study has indicated that Lipiodol flush using HyCoSy may be a safe and efficacious alternative to hysterosalpingography in the workup for infertility. The low adverse effect profile observed in this study coupled with a substantial ongoing pregnancy rate indicates that further investigation of Lipiodol under HyCoSy is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13244","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T17:42:03Z","timestamp":1600969323000},"page":"965-969","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lipiodol flush under ultrasound guidance in Australia"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3044-9277","authenticated-orcid":false,"given":"Jasmin","family":"Sekhon","sequence":"first","affiliation":[{"name":"King Edward Memorial Hospital Perth Western Australia Australia"},{"name":"Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia 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The strength of fish\u2010habitat associations can be indicative of ecosystem resilience, making them important benchmarks for ecological monitoring. These relationships are relatively unknown in mesophotic (30\u2013150\u2009m) marine systems due to the constraints of sampling in deeper waters. We aimed to assess fish\u2010habitat associations in two unstudied no\u2010take National Park Zones in the recently established Abrolhos Marine Park, Western Australia. We used the first baited remote underwater stereo\u2010video systems (stereo\u2010BRUVs) in this area to quantify demersal fish and benthic habitats between 33 and 154\u2009m depth and modelled associations among fish species, traits and environmental covariates using Hierarchical Modelling of Species Communities (HMSC). Significant evidence of species\u2010environment, trait\u2010environment, and species\u2010species associations was identified which may influence local community assembly. Benthic habitats explained 62.4% of the modelled variation in fish abundance, and 7 of the 21 modelled species showed strong statistical relationships with habitat, particularly macroalgae. The modelled species\u2010environment relationships enabled us to infer the distribution of a subset of fish species across these understudied no\u2010take zones. This study demonstrates the potential of discrete opportunistic studies using stereo\u2010BRUVs for investigating the key drivers of community assembly in mesophotic marine environments. 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RNA immunoprecipitation and sequencing identified BMX mRNA as the transcript most significantly disrupted from binding to MSI2 protein, after lncNB knockdown. lncNB or MSI2 knockdown reduced, while their over-expression enhanced, BMX mRNA stability and expression, ERK protein phosphorylation and MYCN non-amplified neuroblastoma cell proliferation. lncNB knockdown significantly suppressed neuroblastoma progression in mice. AlphaScreen of a compound library identified NSC617570 as an efficient inhibitor of lncNB RNA and MSI2 protein interaction, and NSC617570 reduced BMX expression, ERK protein phosphorylation, neuroblastoma cell proliferation in vitro and tumor progression in mice.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Our study demonstrates that lncNB RNA interacts with MSI2 protein to induce neuroblastoma tumorigenesis, and that targeting lncNB and MSI2 interaction with small molecule compounds is an effective anticancer strategy.<\/jats:p>\n <\/jats:sec>\n \n Citation Format:<\/jats:title>\n Sujanna Mondal, Pei Y. Liu, Janith Seneviratne, Antoine De Weck, Pooja Venkat, Chelsea Mayoh, Jing Wu, Jesper Maag, Jingwei Chen, Matthew Wong, Nenad Bartonicek, Poh Khoo, Lei Jin, Louise E. Ludlow, David S. Ziegler, Toby Trahair, Pieter Mestdagh, Belamy B. Cheung, Jinyan Li, Marcel E. Dinger, Ian Street, Xu D. Zhang, Glenn M. Marshall, Tao Liu. The super enhancer-driven long noncoding RNA lncNB promotes neuroblastoma tumorigenesis by interacting with MSI2 protein and is targetable by small molecule compounds [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. 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Hematology","issue":"21","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2014,12,6]]},"abstract":"Abstract<\/jats:title>\n Epidermal growth factor receptor (EGFR) expression is elevated in peripheral blood (PB) cells of polycythemia vera (PV) patients (Skov et al, Eur J Haematol 2011;87:54-60) and EGFR inhibitors (AEE788, erlotinib) inhibit erythroid burst-forming units (BFUE) from PV patients but not normal donors. The mechanism underlying the effect of EGFR inhibitors on MPN progenitor growth has not been established but could be due to an off-target effect on JAK2 activity (Li et al, J Biol Chem 2007;282:3428-32; Gaikwad et al, Exp Hematol 2007;35:1647-56). Therefore, we investigated the growth of BFUE in the presence and absence of the EGFR inhibitor gefitinib (10\u00b5M), which does not inhibit JAK2, and observed inhibition of growth of both erythropoietin (Epo)-dependent and -independent colonies from PB mononuclear cells (PBMNC) from PV patients but not from normal individuals. These results suggest a potential role for EGFR signalling in supporting growth and\/or survival of PV progenitors. Therefore, to evaluate the possibility of somatic genetic abnormalities leading to EGFR hypersensitivity in MPN, we performed targeted exon capture and massively parallel sequencing, and sensitive mass array screening of 155 MPN patient samples. We identified a low-frequency, recurrent somatic variant of EGFR (p. C329R) in 3\/155 MPN patients. The human EGFR C329 residue is homologous to the residue C359 of the C. elegans gene let-23, target of a known gain-of-function mutation (Katz et al, Mol Cell Biol 1996;16(2):529-37); it also aligns with the cysteine residue affected in the highly-transforming mutant ErbB2 C334S found in lung cancer (Greulich et al, PNAS 2012; 109:14476\u201314481); and it lies within the extracellular cysteine-rich region of EGFR that is the target of frequent somatic mutations in glioma. To confirm the hypothesis that the EGFR C329R mutant leads to altered cytokine response, we transduced Ba\/F3 cells with empty vector, EGFR wild type (WT) or mutant constructs (BaF3\/MIG, BaF3\/EGFR and BaF3\/EGFRC329R, respectively). Both WT and mutant receptors showed constitutive activation and transforming ability when expressed at high levels. However, BaF3\/EGFRC329R cells display increased levels of STAT activation associated with a slight proliferation advantage when compared to BaF3\/EGFR.<\/jats:p>\n Given that gefitinib inhibited the growth of both BaF3\/EGFR and BaF3\/EGFRC329R but did not affect BaF3\/MIG cells grown in IL-3, we next compared the effect of gefitinib (10\u00b5M) on the growth of BFUE from PV patient samples with and without the EGFR C329R mutation. We observed significant inhibition of Epo-independent BFUE from all PV samples but not of Epo-dependent BFUE from normal controls (Figure A). Furthermore, genotyping of JAK2 and EGFR from the individual colonies obtained in BFUE assay (treated or not with gefitinib, 10\u00b5M) for a PV patient that is positive for EGFR C329R showed that drug treatment significantly reduced the proportion of JAK2 V617F heterozygous BFUE compared to the vehicle-treated control (chi-squared test = 0.0002, Figure B). This suggests that signalling from EGFR contributes to proliferation and\/or survival in JAK2 V617F heterozygous BFUE from this patient.<\/jats:p>\n The results presented here are consistent with an EGFR signalling role in supporting growth of PV progenitors, particularly in the context of a heterozygous JAK2V617F mutation. STAT5 signalling is essential for PV (Walz et al, Blood 2012;119:3550-3560; Yan et al, Blood 2012;199:3539-3549) and JAK2-independent activation of STAT5 through EGFR (Quesnelle et al, J. Cell. Biochem. 2007; 102:311\u2013319) via various mechanisms may contribute to the level of STAT5 activation required for the PV phenotype. A recent study demonstrating a role for EGFR in hematopoietic stem cells (Doan et al, Nat Med 2013;19:295-304) also highlights the potential of aberrant EGFR signalling to contribute to altered properties of MPN stem cells. Finally, given that gefitinib is currently in clinical use for treatment of solid tumors, these findings raise the possibility that gefitinib may have clinical utility in the context of MPN.<\/jats:p>\n Figure 1 Figure 1.<\/jats:p>\n \n Disclosures<\/jats:title>\n Branford: Novartis: Consultancy, Honoraria, Research Funding; Bristol-Myers Squibb: Honoraria, Research Funding; Ariad: Honoraria, Research Funding; Otsuka: Honoraria, Research Funding.<\/jats:p>\n <\/jats:sec>","DOI":"10.1182\/blood.v124.21.1882.1882","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T06:09:09Z","timestamp":1570687749000},"page":"1882-1882","update-policy":"http:\/\/dx.doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":0,"title":["Aberrant Activation of Epidermal Growth Factor Receptor in MPN May Respond to the Kinase Inhibitor Gefitinib"],"prefix":"10.1182","volume":"124","author":[{"given":"Debora A","family":"Casolari","sequence":"first","affiliation":[{"name":"SA Pathology, Adelaide, Australia"},{"name":"SA Pathology and University of South Australia, Adelaide, Australia"},{"name":"University of South Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana G","family":"Iarossi","sequence":"additional","affiliation":[{"name":"SA Pathology, Adelaide, Australia"},{"name":"University of South Australia, Adelaide, Australia"},{"name":"SA Pathology and University of South Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn M","family":"Butcher","sequence":"additional","affiliation":[{"name":"SA Pathology, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah C","family":"Bray","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia"},{"name":"SA Pathology and University of South Australia, Adelaide, Australia"},{"name":"SA Pathology, Adelaide, Australia"},{"name":"University of Adelaide, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy T","family":"Parker","sequence":"additional","affiliation":[{"name":"SA Pathology, Adelaide, Australia"},{"name":"SA Pathology and University of South Australia, Adelaide, Australia"},{"name":"University of South Australia, Adelaide, Australia"},{"name":"Centre for Cancer Biology, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris N","family":"Hahn","sequence":"additional","affiliation":[{"name":"SA Pathology, Adelaide, Australia"},{"name":"SA Pathology and University of South Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Branford","sequence":"additional","affiliation":[{"name":"SA Pathology and University of South Australia, Adelaide, Australia"},{"name":"SA Pathology, Adelaide, 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The Infliximab User Group","volume":"31","author":"Mortimore","year":"2001","journal-title":"Intern Med J"},{"key":"10.1111\/apt.13880-BIB0023|apt13880-cit-0023","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0140-6736(08)60304-9","article-title":"Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial","volume":"371","author":"D'Haens","year":"2008","journal-title":"Lancet"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.13880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/apt.13880\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T16:46:45Z","timestamp":1625417205000},"score":7.605462,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.13880"}},"issued":{"date-parts":[[2016,12,19]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,2]]}},"URL":"https:\/\/doi.org\/10.1111\/apt.13880","archive":["Portico"],"ISSN":["0269-2813"],"issn-type":[{"value":"0269-2813","type":"print"}],"published":{"date-parts":[[2016,12,19]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:35Z","timestamp":1753890035702,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Objectives: To evaluate fetal and neonatal cardiac morphology by echocardiography in pregnancies complicated by diabetes compared to normal healthy controls using ultrasound.<\/jats:p>\n Methods: Fetal echocardiography was performed in 121 women with uncomplicated singleton pregnancies and 50 women with diabetes in pregnancy. The women underwent ultrasound scans every four weeks from enrolment (between 18-28 weeks gestational age) until delivery. Neonatal echocardiography was performed on the offspring. M-mode assessment was used to assess interventricular septal (IVS) thickness, left ventricle diastolic dimensions (LVED), fractional shortening (FS), tricuspid annular plane systolic excursion (TAPSE) and mitral annular plane systolic excursion (MAPSE).<\/jats:p>\n Results: There were differences in IVS thickness, LVED, FS and TAPSE values between women with uncomplicated pregnancies and women with diabetes in pregnancy. These differences persisted into the neonatal period.<\/jats:p>\n Conclusion: M-mode is a simple ultrasound technique to assess fetal cardiac function. Maternal diabetes was associated with increased IVS thickness, and reduction in TAPSE and FS measures. Prognostic implications of these findings may be useful in assessing pregnancies complicated by maternal diabetes in addition to current ultrasound assessment of fetal size and Doppler studies of fetal vessels.<\/jats:p>\n \n Disclosure<\/jats:title>\n A. Lee-Tannock: None. K. Hay: None. S. Kumar: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Mater Health Services; Australasian Society for Ultrasound in Medicine<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-2252-pub","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:49Z","timestamp":1592238589000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["2252-PUB: Fetal Cardiac Evaluation by Ultrasound to Assess Pregnancies Complicated by Maternal Diabetes"],"prefix":"10.2337","volume":"69","author":[{"given":"ALISON","family":"LEE-TANNOCK","sequence":"first","affiliation":[{"name":"South Brisbane, Australia, Herston, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAREN","family":"HAY","sequence":"additional","affiliation":[{"name":"South Brisbane, Australia, Herston, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SAILESH","family":"KUMAR","sequence":"additional","affiliation":[{"name":"South Brisbane, Australia, Herston, Australia, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/2252-PUB\/57615\/2252-PUB-Fetal-Cardiac-Evaluation-by-Ultrasound-to","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/2252-PUB\/57615\/2252-PUB-Fetal-Cardiac-Evaluation-by-Ultrasound-to","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:40:04Z","timestamp":1647164404000},"score":7.6054335,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/2252-PUB\/57615\/2252-PUB-Fetal-Cardiac-Evaluation-by-Ultrasound-to"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-2252-pub","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"2252-PUB"},{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:55:07Z","timestamp":1784328907609,"version":"3.55.0"},"reference-count":101,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child"],"published-print":{"date-parts":[[2025,7]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>Early detection of cerebral palsy (CP) risk is possible from 12\u2009weeks corrected gestational age (CGA) using standardised assessments; however, up to half of children at risk are not referred early, missing out on early intervention. We investigated the barriers and facilitators to accessing early intervention from the perspective of parents of children who did not receive services by 6\u2009months CGA.<\/jats:p><\/jats:sec>Methods<\/jats:title>Parents of children with CP were invited to participate in qualitative semistructured interviews. Reflexive thematic analysis was used to analyse the data and develop themes.<\/jats:p><\/jats:sec>Results<\/jats:title>Eight mothers of children who did not receive standardised screening participated in interviews, from which three themes, \u2018responding to delays\u2019, \u2018systemic barriers\u2019 and \u2018complexities of diagnosis\u2019, were developed from the data.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Parents require more support to access and engage in early detection services; health system processes are difficult to navigate, and health professionals require education and training to recognise risk factors for CP in all health settings and refer promptly. Improving system processes, education and training and partnering early with parents to improve their experience when interacting with the health system may increase early engagement and optimise long\u2010term outcomes for children at risk of CP and their families.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cch.70100","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T17:10:41Z","timestamp":1748452241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["\u2018Feeling like you can't do anything because you don't know where to start\u2019\u2014Parents' Perspectives of Barriers and Facilitators to Accessing Early Detection for Children at Risk of Cerebral Palsy"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6795-1466","authenticated-orcid":false,"given":"Sue\u2010Anne","family":"Davidson","sequence":"first","affiliation":[{"name":"Kids Rehab WA Perth Children's Hospital Perth Western Australia Australia"},{"name":"School of Allied Health Curtin University Perth Western Australia Australia"},{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashleigh","family":"Thornton","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"},{"name":"Division of Paediatrics, Medical School The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Hersh","sequence":"additional","affiliation":[{"name":"School of Allied Health Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtenay","family":"Harris","sequence":"additional","affiliation":[{"name":"School of Allied Health Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Elliott","sequence":"additional","affiliation":[{"name":"School of Allied Health Curtin University Perth Western Australia Australia"},{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Valentine","sequence":"additional","affiliation":[{"name":"Kids Rehab WA Perth Children's Hospital Perth Western Australia Australia"},{"name":"School of Allied Health Curtin University Perth Western Australia Australia"},{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"},{"name":"Division of Paediatrics, Medical School The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"ABS.2016.Remoteness Structure. 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Access, equity, care of chronic conditions and quality are key priorities in primary care in Australia.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A large-scale quality improvement collaborative addressing diabetes, coronary heart disease (CHD), access, chronic obstructive pulmonary disease (COPD), patient self-management, Aboriginal health and diabetes prevention.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n General practices and Aboriginal medical services across Australia.<\/jats:p>\n <\/jats:sec>\n \n Key Measures for Improvement<\/jats:title>\n Sample measures are reported.<\/jats:p>\n <\/jats:sec>\n \n Strategy for Change<\/jats:title>\n The Improvement Foundation (Australia) adapted collaborative strategies used in the UK. Health service teams attended three workshops, separated by activity periods and followed by 12\u2005months of further work. Teams were supported by local collaborative program managers to make changes and report measures. Services received feedback about improvement compared with their wave.<\/jats:p>\n <\/jats:sec>\n \n Effects of Change<\/jats:title>\n 1185 health services participated in 13 waves between 2005 and 2011. 83% of Australian divisions of general practice participated, and 262 support staff received quality improvement training. Key measures show improvement in all topics except access. 397\u2008111 patients were on the disease registers of participating health services.<\/jats:p>\n <\/jats:sec>\n \n Lessons learnt<\/jats:title>\n The collaborative methodology is transferable to primary care in Australia. Results may reflect improved data recording and disease coding, as well as changes in clinical care. Team dynamics and local support are important success factors. Collaboratives are a useful tool in a program of clinical quality improvement. The APCC will work with the new primary healthcare organisations which are part of health reforms in Australia to improve data reporting, improve diabetes care and entrench quality improvement in the emerging environment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjqs-2011-000165","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T12:17:20Z","timestamp":1342181840000},"page":"948-955","source":"Crossref","is-referenced-by-count":32,"title":["Improving primary care in Australia through the Australian Primary Care Collaboratives Program: a quality improvement report"],"prefix":"10.1136","volume":"21","author":[{"given":"Andrew W","family":"Knight","sequence":"first","affiliation":[{"name":"The Australian Primary Care Collaboratives Program, The Improvement Foundation (Australia), Katoomba, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Caesar","sequence":"additional","affiliation":[{"name":"The Improvement Foundation (Australia), South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Ford","sequence":"additional","affiliation":[{"name":"The Improvement Foundation (Australia), South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Coughlin","sequence":"additional","affiliation":[{"name":"The Improvement Foundation (Australia), South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Frick","sequence":"additional","affiliation":[{"name":"The Improvement Foundation (Australia), South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,7,12]]},"reference":[{"key":"2025090413370675000_21.11.948.1","unstructured":"The Institute for Healthcare Improvement. 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Common wealth of Australia, 2008. http:\/\/www.aihw.gov.au\/publication-detail\/?id=6442468085 (accessed 19 Oct 2011)."},{"key":"2025090413370675000_21.11.948.20","unstructured":"The Australian Primary Care Collaboratives Program. APCC Program Topic Measures and Other Improvement Measures. 2010. http:\/\/www.apcc.org.au\/images\/uploads\/APCC%20Program%20Measures%20-%20Vendor%20-%20Final.pdf (accessed 19 Oct 2011)."},{"key":"2025090413370675000_21.11.948.21","first-page":"71","article-title":"Learning from four years of collaborative access work in Australia","volume":"17","author":"Knight","year":"2009","journal-title":"Qual Prim Care"},{"key":"2025090413370675000_21.11.948.22","unstructured":"Langley G Nolan K Nolan T . The Improvement Guide: A Practical Approach to Enhancing Organizational Performance. San Francisco: Jossey-Bass, 1996."},{"key":"2025090413370675000_21.11.948.23","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.5.829"}],"container-title":["BMJ Quality & Safety"],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjqs-2011-000165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T20:37:15Z","timestamp":1757018235000},"score":7.605365,"resource":{"primary":{"URL":"https:\/\/qualitysafety.bmj.com\/lookup\/doi\/10.1136\/bmjqs-2011-000165"}},"issued":{"date-parts":[[2012,7,12]]},"references-count":23,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,10,24]]},"published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1136\/bmjqs-2011-000165"],"URL":"https:\/\/doi.org\/10.1136\/bmjqs-2011-000165","ISSN":["2044-5415","2044-5423"],"issn-type":[{"value":"2044-5415","type":"print"},{"value":"2044-5423","type":"electronic"}],"published":{"date-parts":[[2012,7,12]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:38:43Z","timestamp":1753889923009,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: Haptoglobin (HP) is a circulating glycoprotein with antioxidant and anti-inflammatory properties. It scavenges toxic free hemoglobin. Cardiovascular disease (CVD) risk in Type 2 diabetes (T2D) patients may differ by HP phenotype. It is unknown if CVD risk and fenofibrate benefits differ by HP levels.<\/jats:p>\n Methods: HP phenotype and levels were measured in baseline plasma from 8047 T2D adults in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial by ELISA and immunoturbidimetric assay, respectively.<\/jats:p>\n Results: Frequencies of HP 1-1, 2-1 and 2-2 phenotypes were 15.6%, 47.6% and 36.9% respectively. Higher HP level tertiles, but not HP phenotype, were associated with a higher risk of total CVD events, especially coronary heart disease events (P=0.019) and CVD mortality (P=0.003) in placebo group, after adjustment for CVD risk factors (overall P for trend =0.032, Fig. 1A). The HP level association was independently significant only in the HP 1-1 phenotype (P for level\/phenotype interaction =0.039, Fig. 1B). Participants with both HP 1-1 phenotype and the lowest HP tertile levels tended to have the lowest CVD risk (Fig. 1C). Fenofibrate benefits on total CVD events did not differ by HP phenotype or levels.<\/jats:p>\n Conclusion: HP levels and phenotype help to identify T2D patients at high CVD risk for treatment, especially those with HP 1-1 phenotype.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n K. Ong: None. A.S. Januszewski: None. H. Francis: None. R.L. O'Connell: None. A. Mangani: None. L. Li: None. P.G. Colman: None. D. Sullivan: Other Relationship; Amgen Inc. Research Support; Arrowhead Pharmaceuticals, Inc. Other Relationship; Novartis Pharmaceuticals Corporation, Merck Sharp & Dohme Corp. Research Support; Ionis Pharmaceuticals. J.D. Best: None. R.S. Scott: None. A. Jenkins: Advisory Panel; Abbott. Speaker's Bureau; GlaxoSmithKline plc. Research Support; Abbott, Metronics, Ypsomed AG, Insulet Corporation, Jaeb Center for Health Research, Endogenex, Hemsley Charitable Trust. Speaker's Bureau; CSL Seqirus. Research Support; AbbVie Inc, National Institutes of Health, Juvenile Diabetes Research Foundation (JDRF). A.C. Keech: Research Support; Abbott, Amgen Inc, ASPEN Australia, Mylan. Speaker's Bureau; Novartis AG, Pfizer Inc. Research Support; Kowa Company, Ltd. Speaker's Bureau; Sanofi. Research Support; AbbVie Inc, Viatris Inc.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Laboratoires Fournier, Dijon, France and the National Health and Medical Research Council of Australia (457103, 1024105, 1037786, 1105467, 1121272, 1137071 and 2018537)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-1314-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:30:42Z","timestamp":1749792642000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1314-P: Association of Haptoglobin Levels and Phenotype with Cardiovascular Disease in Adults with Type 2 Diabetes\u2014A FIELD Trial Substudy"],"prefix":"10.2337","volume":"74","author":[{"given":"KWOK","family":"LEUNG ONG","sequence":"first","affiliation":[{"name":"Parkville, Australia, Sydney, Australia, Singapore, Singapore, Christchurch, New Zealand, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Sydney, Australia, Singapore, Singapore, Christchurch, New Zealand, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HABIB","family":"FRANCIS","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Sydney, Australia, Singapore, Singapore, Christchurch, New Zealand, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RACHEL L.","family":"O'CONNELL","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Sydney, Australia, Singapore, Singapore, Christchurch, New Zealand, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ABUBAKAR","family":"SIDDIQ MANGANI","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Sydney, Australia, Singapore, Singapore, Christchurch, New Zealand, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LIPING","family":"LI","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Sydney, Australia, Singapore, Singapore, Christchurch, New Zealand, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER G.","family":"COLMAN","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Sydney, Australia, Singapore, Singapore, Christchurch, New Zealand, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"SULLIVAN","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Sydney, Australia, Singapore, Singapore, Christchurch, New Zealand, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAMES D.","family":"BEST","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Sydney, Australia, Singapore, Singapore, Christchurch, New Zealand, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RUSSELL S.","family":"SCOTT","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Sydney, Australia, Singapore, Singapore, Christchurch, New Zealand, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Sydney, Australia, Singapore, Singapore, Christchurch, New Zealand, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTHONY C.","family":"KEECH","sequence":"additional","affiliation":[{"name":"Parkville, Australia, Sydney, Australia, Singapore, Singapore, Christchurch, New Zealand, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1314-P\/158922\/1314-P-Association-of-Haptoglobin-Levels-and","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1314-P\/158922\/1314-P-Association-of-Haptoglobin-Levels-and","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T15:59:46Z","timestamp":1750435186000},"score":7.6053467,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/1314-P\/158922\/1314-P-Association-of-Haptoglobin-Levels-and"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-1314-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"1314-P"},{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:39:49Z","timestamp":1778153989241,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100031198","name":"Department of Health, Government of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Peanut allergy is the most common childhood\u2010onset, persistent food allergy. Peanut oral immunotherapy (OIT) is a potential treatment, but few studies prospectively examine the outcome of peanut OIT in young children using parent\u2010measured doses compared to standard care (peanut avoidance).<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To determine the efficacy, safety and tolerability of a pragmatic peanut OIT protocol (parent\u2010measured doses with low maintenance dose) compared to avoidance.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this unblinded randomised controlled trial (1:1 ratio), children 1\u20134\u2009years\u2009old were assigned to receive peanut OIT (maintenance dose 360\u2009mg) or avoidance for 12\u2009months. The primary outcome was desensitisation, defined as the ability to tolerate at least 600\u2009mg peanut protein during an end\u2010of\u2010treatment oral food challenge (EOT OFC), with secondary outcomes frequency and severity of adverse events, change in quality of life and change in immunological markers of peanut allergy.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 54 children were randomised, with 23\/27 in the peanut OIT and 25\/27 in the avoidance group undergoing open peanut challenge after 12\u2009months. An eliciting dose of \u2265\u2009600\u2009mg peanut protein was tolerated by 74% (20\/27) of OIT compared to 11% (3\/27) of avoidance participants. 41% of OIT (11\/27) and 7% of avoidance (2\/27) participants passed the end\u2010of\u2010treatment challenge. The OIT group reported significantly better quality of life than the avoidance group after 12\u2009months (Food Allergy Quality of Life Questionnaire\u2010Parent Form mean difference \u22120.5,\n p<\/jats:italic>\n \u2009=\u20090.041). There were 79 treatment\u2010related adverse events reported by 21 participants in the OIT group (median 2 per participant, range 0\u201313).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Peanut OIT using parent\u2010measured doses and a low maintenance dose of 360\u2009mg is effective at inducing desensitisation after 12\u2009months in 1\u2010 to 4\u2010year\u2010old children. In this cohort, peanut OIT is associated with improved quality of life compared to avoidance and appears to have an acceptable safety profile.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n Australian New Zealand Clinical Trials Registry<\/jats:ext-link>\n : ACTRN12621001001886 (registered 30 July 2021)\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cea.70126","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T05:43:55Z","timestamp":1754372635000},"page":"1093-1104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pragmatic Low\u2010Dose Oral Immunotherapy for Preschool Children With Peanut Allergy: A Randomised Controlled Trial"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7896-2697","authenticated-orcid":false,"given":"Michael","family":"O'Sullivan","sequence":"first","affiliation":[{"name":"Immunology Department Perth Children's Hospital Nedlands Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"},{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Wallace","sequence":"additional","affiliation":[{"name":"Immunology Department Perth Children's Hospital Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Thomas","sequence":"additional","affiliation":[{"name":"Immunology Department Perth Children's Hospital Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa","family":"Godfrey","sequence":"additional","affiliation":[{"name":"Immunology Department Perth Children's Hospital Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Bear","sequence":"additional","affiliation":[{"name":"Immunology Department Perth Children's Hospital Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhaumik","family":"Mevavala","sequence":"additional","affiliation":[{"name":"Immunology Department Perth Children's Hospital Nedlands Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Miller","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Roche","sequence":"additional","affiliation":[{"name":"Advanced Dietitians Group Leederville Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samara","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Immunology Department Perth Children's Hospital Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica R.","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"Immunology Department Perth Children's Hospital Nedlands Western Australia Australia"},{"name":"The Kids Research Institute Australia Nedlands Western Australia 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Society of Clinical Immunology and Allergy \u201cPosition Paper\u2014Oral Immunotherapy for Food Allergy\u201d(2023) https:\/\/www.allergy.org.au\/hp\/papers\/ascia\u2010oral\u2010immunotherapy\u2010for\u2010food\u2010allergy."},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2022.100687"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.08.007"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-020-0413-7"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15211"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2023-002294"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.017"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.01.003"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02978.x"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-012-0295-3"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12599"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.08.007"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.08.015"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.10.045"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.02.030"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12213"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03454.x"},{"key":"e_1_2_13_40_1","unstructured":"Aimmune Therapeutics \u201cPalforzia Prescribing Information\u201d[Internet] (US Food and Drug Administration 2024) https:\/\/www.fda.gov\/media\/134838\/download."},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212895"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.056"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.11.034"}],"container-title":["Clinical & Experimental Allergy"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.70126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cea.70126","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.70126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:22:34Z","timestamp":1771464154000},"score":7.605083,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.70126"}},"issued":{"date-parts":[[2025,8,4]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/cea.70126"],"URL":"https:\/\/doi.org\/10.1111\/cea.70126","archive":["Portico"],"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"published":{"date-parts":[[2025,8,4]]},"assertion":[{"value":"2025-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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This study examines the effects of long term high fat diet (HFD) and DM on rodent skeletal muscle ECM were addressed. Five week old C57BL\/6 male mice were randomly allocated to standard chow (control; n=26) or HFD (45% kcal fat; n=25). After 15 weeks chow and HFD mice were rendered diabetic (by low dose STZ, 65mg\/kgx3d, I.P.) (DM, n=14; HFD+DM, n=14); nondiabetic mice acted as controls. Mice were euthanased after 30 weeks and plasma and quadriceps muscle were collected for analysis. Body weight and plasma insulin expectedly decreased with DM induction and increased with HFD (all p&lt;0.05). High glucose occurred only in DM mice (\u223c14 mM; p&lt;0.05), whereas only HFD increased muscle triglyceride (p&lt;0.05). Both conditions induced a decrease in quadriceps weight and in grip strength performance (p&lt;0.05). Quadriceps of DM mice showed increased CTGF\/CCN2 (1.5-fold; p&lt;0.05), TIMP-1 (2-fold; p&lt;0.05), collagen-I (3-fold; p&lt;0.05), -IV (2-fold; p&lt;0.05), and -VI (2-fold; p&lt;0.05) protein. In contrast, HFD induced a downregulation of CTGF\/CCN2 (0.6-fold; p&lt;0.05), MMP-1 (0.6-fold; p&lt;0.05), and TIMP-2 (0.4-fold; p&lt;0.05). In DM mice quadriceps centralized nuclei (p&lt;0.05) and caspase 3 (protein; 1.5-fold; p&lt;0.05) were increased, whereas caspase 3 was decreased in HFD (0.5-fold; p&lt;0.05). Moreover, HFD induced a downregulation of ubiquitin ligase atrogin-1 protein (0.5-fold; p&lt;0.05) and mRNA levels of serine\/threonine kinase p70S6k (0.75-fold; p&lt;0.05). Notably, no greater dysregulation of the muscle changes observed with DM alone or with HFD alone, was seen in HFD+DM mice. These data suggest that DM and HFD differentially affect skeletal muscle ECM: DM promotes a pro-fibrotic profile with signs of muscle damage, and HFD impairs regulatory protein turnover pathways, each inducing muscle dysfunction.<\/jats:p>\n \n Disclosure<\/jats:title>\n S.F. Martinez-Huenchullan: None. L.A. Ban: None. A. Tao: None. S.S. Sutanto: None. C. Tam: None. S. McLennan: None. S.M. Twigg: Advisory Panel; Self; Abbott. Consultant; Self; Abbott. Advisory Panel; Self; Novo Nordisk Inc., Sanofi-Aventis, AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company. Speaker's Bureau; Self; AstraZeneca, Merck Sharp & Dohme Corp.. Other Relationship; Self; Abbott.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-1923-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:33Z","timestamp":1529693853000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":3,"title":["Diabetes and High-Fat Diet Induce Different Pathologies in Mouse Skeletal Muscle Extracellular Matrix"],"prefix":"10.2337","volume":"67","author":[{"given":"SERGIO F.","family":"MARTINEZ-HUENCHULLAN","sequence":"first","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LINDA A.","family":"BAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANH","family":"TAO","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SURYA S.","family":"SUTANTO","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHARMAINE","family":"TAM","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUSAN","family":"MCLENNAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN M.","family":"TWIGG","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1923-P\/55387\/Diabetes-and-High-Fat-Diet-Induce-Different","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1923-P\/55387\/Diabetes-and-High-Fat-Diet-Induce-Different","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:32:34Z","timestamp":1647163954000},"score":7.604991,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/1923-P\/55387\/Diabetes-and-High-Fat-Diet-Induce-Different"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-1923-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"1923-P"},{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:03:25Z","timestamp":1788869005901,"version":"build-2803163510"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"LotteryWest"},{"name":"West Australian Government"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2023,8,1]]},"abstract":"Abstract<\/jats:title>\n Extensive qualitative evidence, but limited quantitative evidence, indicates that mutual aid organizations such as Men\u2019s Sheds have positive impacts on wellbeing, health-related quality of life, and loneliness. A recently developed theoretical model proposes that Men\u2019s Sheds may have these impacts via mediating factors such as broadening social networks, increasing behavioural activation and physical activity, reducing alcohol use, and providing meaning in life. The aim of this study was to quantitatively test a model whereby psychological safety (feeling safe, accepted, and valued) is associated with Men\u2019s Shed engagement (frequency of attendance, duration of membership, diversity of activities), which is associated with the hypothesized mediators, which, in turn, are associated with wellbeing, health-related quality of life, and loneliness. Men\u2019s Shed members (N\u2005=\u2005333, Mage\u2005=\u200570.90 years, SD\u2005=\u200510.34, 98% male) completed a survey assessing the factors in the model. The hypothesized path model provided an excellent fit to the data. Findings indicated that higher psychological safety was associated with higher engagement, which, in turn, was associated with larger social networks and more meaning in life, which were associated with higher wellbeing and lower loneliness. Higher behavioural activation and less alcohol use were also associated with higher wellbeing. Higher Men\u2019s Shed engagement was not associated with higher behavioural activation and physical activity, or less alcohol use, but behavioural activation and alcohol use were directly associated with health-related quality of life. Implications for optimizing health outcomes within Men\u2019s Sheds are discussed.<\/jats:p>","DOI":"10.1093\/heapro\/daad084","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:24Z","timestamp":1690156824000},"source":"Crossref","is-referenced-by-count":16,"title":["Pathways from Men\u2019s Shed engagement to wellbeing, health-related quality of life, and lower loneliness"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2924-6760","authenticated-orcid":false,"given":"Peter M","family":"McEvoy","sequence":"first","affiliation":[{"name":"School of Population Health , Perth, Western Australia , Australia"},{"name":"enAble Institute, Curtin University , Perth, Western Australia , Australia"},{"name":"Centre for Clinical Interventions, North Metropolitan Health Service , Perth, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Holmes","sequence":"additional","affiliation":[{"name":"School of Management and Marketing, Curtin University , Perth, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan J","family":"Smith","sequence":"additional","affiliation":[{"name":"School of Population Health , Perth, Western Australia , Australia"},{"name":"enAble Institute, Curtin University , Perth, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Bullen","sequence":"additional","affiliation":[{"name":"enAble Institute, Curtin University , Perth, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian W","family":"Chiu","sequence":"additional","affiliation":[{"name":"School of Population Health , Perth, Western Australia , Australia"},{"name":"enAble Institute, Curtin University , Perth, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Wild","sequence":"additional","affiliation":[{"name":"Men\u2019s Sheds of Western Australia , Perth, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaxon","family":"Ashley","sequence":"additional","affiliation":[{"name":"Men\u2019s Sheds of Western Australia , Perth, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Talbot","sequence":"additional","affiliation":[{"name":"Men\u2019s Sheds of Western Australia , Perth, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"2023081613255271700_CIT0001","author":"Australian Bureau of 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Policy"},{"key":"2023081613255271700_CIT0053","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1017\/S0144686X16001331","article-title":"Older men\u2019s perceptions of the need for and access to male-focused community programmes such as men\u2019s sheds","volume":"38","author":"Nurmi","year":"2018","journal-title":"Ageing and Society"},{"key":"2023081613255271700_CIT0054","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s00127-019-01778-8","article-title":"The bidirectional relationship between loneliness and common mental disorders in adults: findings from a longitudinal population-based cohort study","volume":"55","author":"Nuyen","year":"2019","journal-title":"Social Psychiatry and Psychiatric Epidemiology"},{"key":"2023081613255271700_CIT0055","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1365-2524.2010.00932.x","article-title":"Older men\u2019s participation in community-based men\u2019s sheds programmes","volume":"18","author":"Ormsby","year":"2010","journal-title":"Health and Social Care in the Community"},{"key":"2023081613255271700_CIT0056","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1177\/10731911221119533","article-title":"Measuring loneliness in different age groups: the measurement invariance of the UCLA Loneliness Scale","volume":"30","author":"Panayiotou","year":"2023","journal-title":"Assessment"},{"key":"2023081613255271700_CIT0057","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s001270170044","article-title":"How does drug and alcohol misuse develop among people with psychotic illness? A literature review","volume":"36","author":"Phillips","year":"2001","journal-title":"Social Psychiatry and Psychiatric Epidemiology"},{"key":"2023081613255271700_CIT0058","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11336-009-9135-y","article-title":"Ensuring positiveness of the scaled difference chi-square test statistic","volume":"75","author":"Satorra","year":"2010","journal-title":"Psychometrika"},{"key":"2023081613255271700_CIT0059","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1037\/0022-0167.53.1.80","article-title":"The Meaning in Life Questionnaire: assessing the presence of and search for meaning in life","volume":"53","author":"Steger","year":"2006","journal-title":"Journal of Counseling Psychology"},{"key":"2023081613255271700_CIT0060","volume-title":"Using Multivariate Statistics","author":"Tabachnick","year":"2013","edition":"6th edition"},{"key":"2023081613255271700_CIT0061","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000376585","article-title":"The WHO-5 well-being index: a systematic review of the literature","volume":"84","author":"Topp","year":"2015","journal-title":"Psychotherapy and Psychosomatics"},{"key":"2023081613255271700_CIT0062","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/da.22771","article-title":"Self-medication with alcohol or drugs for mood and anxiety disorders: a narrative review of the epidemiological literature","volume":"35","author":"Turner","year":"2018","journal-title":"Depression and Anxiety"},{"key":"2023081613255271700_CIT0063","doi-asserted-by":"crossref","first-page":"S245","DOI":"10.1093\/geronb\/54B.5.S245","article-title":"Variation in the impact of social network characteristics on physical functioning in elderly persons: MacArthur studies of successful aging","volume":"54B","author":"Unger","year":"1999","journal-title":"Journal of Gerontology: Social Sciences"},{"key":"2023081613255271700_CIT0064","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/hsc.12365","article-title":"\u2018Don\u2019t fix what ain\u2019t broke\u2019: evaluating the effectiveness of a Men\u2019s Shed in inner-regional Australia","volume":"25","author":"Waling","year":"2017","journal-title":"Health and Social Care in the Community"},{"key":"2023081613255271700_CIT0065","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/hsc.12019","article-title":"A narrative review of Men\u2019s Sheds literature: reducing social isolation and promoting men\u2019s health and well-being","volume":"21","author":"Wilson","year":"2013","journal-title":"Health and Social Care in the Community"},{"key":"2023081613255271700_CIT0066","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/hpja.217","article-title":"An examination of health promotion and social inclusion activities: a cross-sectional survey of Australian community Men\u2019s Sheds","volume":"30","author":"Wilson","year":"2019","journal-title":"Health Promotion Journal of Australia"},{"key":"2023081613255271700_CIT0068","volume-title":"The Alcohol Use Disorders Identification Test: Guidelines for Use in Primary Care","author":"World Health Organization","year":"2001","edition":"2nd edition"}],"container-title":["Health Promotion International"],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/heapro\/article-pdf\/38\/4\/daad084\/51116790\/daad084.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/heapro\/article-pdf\/38\/4\/daad084\/51116790\/daad084.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T09:26:32Z","timestamp":1692177992000},"score":7.604982,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/heapro\/article\/doi\/10.1093\/heapro\/daad084\/7243093"}},"issued":{"date-parts":[[2023,8,1]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/heapro\/daad084","ISSN":["0957-4824","1460-2245"],"issn-type":[{"value":"0957-4824","type":"print"},{"value":"1460-2245","type":"electronic"}],"published-other":{"date-parts":[[2023,8,1]]},"published":{"date-parts":[[2023,8,1]]},"article-number":"daad084"},{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:55:08Z","timestamp":1761897308572,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Background: Faster-acting insulin aspart (FiAsp) may improve responsiveness of closed-loop (CL) systems and provide better postprandial glucose (PPG) management due to its more rapid onset and offset compared to insulin aspart (Asp). The Medtronic Advanced Hybrid Closed Loop (AHCL) System features auto-basal and auto-bolus functions.<\/jats:p>\n Aim: To compare PPG control using FiAsp vs. Asp delivered using AHCL.<\/jats:p>\n Methods: Twelve adults with T1D (median HbA1c 7.1% [IQR 6.8, 7.2]; 54mmol\/mol [51, 55]) were assigned to FiAsp or Asp (unblinded) in random-order over two-stages (6-weeks duration each) using AHCL. Postprandial periods were defined using set time-blocks for breakfast (06:00-10:00); lunch (11:00-15:00); and dinner (17:00-21:00), based on conventional meal-times and meal distribution. CGM data was analyzed using signed-rank test.<\/jats:p>\n Results: With all postprandial time-block data aggregated, FiAsp demonstrated greater overall time-in-range (TIR) (70-180mg\/dL) (p=0.028) and less hyperglycaemia (p=0.041) compared with Asp (Table). TIR was greater during lunch (p=0.034) for FiAsp vs. Asp, with no difference during breakfast or dinner. Over the 6-week duration, FiAsp use trended towards greater TIR vs. Asp (82.7% vs. 80.4%, p=0.07).<\/jats:p>\n Conclusions: FiAsp appears to confer an advantage compared with Asp for PPG control whilst using AHCL even in subjects with high overall TIR.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n M.H. Lee: Research Support; Self; Medtronic. Speaker\u2019s Bureau; Self; AstraZeneca, Medtronic. S. Vogrin: None. B. Paldus: Research Support; Self; JDRF. Speaker\u2019s Bureau; Self; Australian Diabetes Society, Medtronic. D. Morrison: None. D. Zaharieva: Speaker\u2019s Bureau; Self; Ascensia Diabetes Care, Insulet Corporation, Medtronic. J. Lu: None. H. Jones: None. S.A. Wyatt: Other Relationship; Self; Medtronic, Ypsomed AG. E. Netzer: None. C.M. Sims: Stock\/Shareholder; Self; Medtronic. R. MacIsaac: None. B. Grosman: Employee; Self; Medtronic. A. Roy: Employee; Self; Medtronic. N. Kurtz: Employee; Self; Medtronic. A. Jenkins: Advisory Panel; Self; Abbott, Medtronic. Research Support; Self; Abbott, GlySens Incorporated, Medtronic, Sanofi-Aventis. D.N. ONeal: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-234-or","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:49Z","timestamp":1592238589000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":3,"title":["234-OR: Postprandial Glucose Control Using the Medtronic Advanced Hybrid Closed-Loop System: Faster-Acting Insulin Aspart vs. Insulin Aspart"],"prefix":"10.2337","volume":"69","author":[{"given":"MELISSA H.","family":"LEE","sequence":"first","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SARA","family":"VOGRIN","sequence":"additional","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BARBORA","family":"PALDUS","sequence":"additional","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DALE","family":"MORRISON","sequence":"additional","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DESSI","family":"ZAHARIEVA","sequence":"additional","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEAN","family":"LU","sequence":"additional","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HANNAH","family":"JONES","sequence":"additional","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUE A.","family":"WYATT","sequence":"additional","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EMMA","family":"NETZER","sequence":"additional","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CATRIONA M.","family":"SIMS","sequence":"additional","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"MACISAAC","sequence":"additional","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BENYAMIN","family":"GROSMAN","sequence":"additional","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANIRBAN","family":"ROY","sequence":"additional","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NATALIE","family":"KURTZ","sequence":"additional","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"ONEAL","sequence":"additional","affiliation":[{"name":"Stanford, CA, Melbourne, Australia, Northridge, CA, Agoura Hills, CA, Sydney, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/234-OR\/56856\/234-OR-Postprandial-Glucose-Control-Using-the","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/234-OR\/56856\/234-OR-Postprandial-Glucose-Control-Using-the","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:50:59Z","timestamp":1647165059000},"score":7.6049705,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/234-OR\/56856\/234-OR-Postprandial-Glucose-Control-Using-the"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-234-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"234-OR"},{"indexed":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:15:08Z","timestamp":1715732108414},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"suppl_1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2012,2]]},"abstract":"Persistent motor disability limits the capacity of stroke patients to retain or regain physical fitness. Increased metabolic demands of hemiparetic gait, physical deconditioning, and secondary muscle changes including atrophy and a shift in muscle fibre phenotype, combine to reduce post-stroke aerobic capacity by \u223c50%. Fitness may be overlooked in rehabilitation programs when primary goals are centred on speech and effective locomotion. In this study we investigated whether cardiovascular fitness could be improved using Wii-based movement therapy that specifically targets hand and upper limb function. We studied 15 male and 3 female patients with post-stroke hemiparesis, mean age 61.4 years (range 22-75 years), mean time post-stroke 21.7 months (range 5-91 months). All patients completed the 2 week program with one hour of formal therapy on 10 consecutive weekdays augmented by home practice using the standard Wii Sports games of baseball, bowling, boxing, golf and tennis. Heart rate was recorded continuously using wireless telemetry during formal therapy sessions at three time points: early, mid and late therapy. During the same sessions the number of steps during tennis and boxing was counted from video recordings. Functional ability was assessed before and after therapy using the Wolf Motor Function Test (WMFT) and the Motor Activity Log (MAL). Peak heart rate significantly increased from early to late therapy (p<0.001), becoming 38% higher on average than resting rates by late therapy. A sport-specific gradient was evident with increases in peak heart rate ranging from 20.9% in golf to 49.0% in boxing (p<0.001). A concomitant improvement in exercise endurance was also noted. These changes occurred despite most patients being treated with beta blockers and ace-inhibitors. Functional ability improved by 23% (WMFT, p=0.037) which transferred to everyday tasks with a 127% improvement (MAL) (both p<0.001). In conclusion these results suggest that Wii-based movement therapy not only improves upper limb function but also provides a cardiovascular challenge, mitigating the marked reduction in fitness commonly reported post-stroke. The differential effect on heart rate of the basic Wii Sports games provides a further avenue to tailor therapy for individual patients according for cardiac status and fitness levels.<\/jats:p>","DOI":"10.1161\/str.43.suppl_1.a3339","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T11:03:18Z","timestamp":1625310198000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Abstract 3339: Cardiovascular Benefits of Wii-based Movement Therapy for Upper Limb Post-stroke Rehabilitation"],"prefix":"10.1161","volume":"43","author":[{"given":"Penelope A","family":"McNulty","sequence":"first","affiliation":[{"name":"Neuroscience Rsch Australia, Randwick NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Trinh","sequence":"additional","affiliation":[{"name":"Neuroscience Rsch Australia, Randwick NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E","family":"Scheuer","sequence":"additional","affiliation":[{"name":"Neuroscience Rsch Australia, Randwick NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine T","family":"Shiner","sequence":"additional","affiliation":[{"name":"Neuroscience Rsch Australia, Randwick NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaven G","family":"Lin","sequence":"additional","affiliation":[{"name":"Neuroscience Rsch Australia, Randwick NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica G","family":"Thompson-Butel","sequence":"additional","affiliation":[{"name":"Neuroscience Rsch Australia, Randwick NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00007670-201202001-00696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T03:47:35Z","timestamp":1715658455000},"score":7.6047935,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/str.43.suppl_1.A3339"}},"issued":{"date-parts":[[2012,2]]},"references-count":0,"journal-issue":{"issue":"suppl_1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1161\/str.43.suppl_1.A3339"],"URL":"https:\/\/doi.org\/10.1161\/str.43.suppl_1.a3339","ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"2018-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:30:40Z","timestamp":1784647840433,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T00:00:00Z","timestamp":1535414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Objective<\/jats:title>To identify which preoperative patient characteristics influence sequential bilateral cochlear implantation performance and to create a statistical model that predicts benefit.<\/jats:p><\/jats:sec>Design<\/jats:title>Multicentre retrospective cohort study.<\/jats:p><\/jats:sec>Setting<\/jats:title>All patients were operated in four academic teaching hospitals in Perth, Australia, and followed up by audiologists of the Ear Science Institute Australia.<\/jats:p><\/jats:sec>Participants<\/jats:title>A total of 92 postlingually deafened adult patients who had undergone sequential cochlear implantations between 19 June 1990 and 14 March 2016 were included. Patients were excluded if the 12\u2010month follow\u2010up consonant\u2010nucleus\u2010consonant (CNC<\/jats:styled-content>) phoneme score was missing.<\/jats:p><\/jats:sec>Main outcome measure<\/jats:title>The effect of 18 preoperative factors on the CNC<\/jats:styled-content> phoneme score in quiet (at 65 dB SPL<\/jats:styled-content>) with the second cochlear implant (CI<\/jats:styled-content>2) one year after implantation.<\/jats:p><\/jats:sec>Results<\/jats:title>Two factors were positively correlated to speech understanding with CI<\/jats:styled-content>2: Wearing a hearing aid (HA<\/jats:styled-content>) before receiving CI<\/jats:styled-content>2 (r<\/jats:italic> = 0.46, P<\/jats:italic> = 0.00) and the maximum CNC<\/jats:styled-content> phoneme score with the first CI<\/jats:styled-content> (CI<\/jats:styled-content>1) (r<\/jats:italic> = 0.21, P<\/jats:italic> = 0.05). Two factors were negatively correlated: the length of hearing loss before CI<\/jats:styled-content>2 in the second implanted ear (r<\/jats:italic> = \u22120.25, P<\/jats:italic> = 0.02) and preoperative pure tone average (PTA<\/jats:styled-content>) (0.5, 1, 2 kHz) before CI<\/jats:styled-content>2 in the second implanted ear (r<\/jats:italic> = \u22120.27, P<\/jats:italic> = 0.01). The following model could be created: predicted CNC<\/jats:styled-content> phoneme score with CI<\/jats:styled-content>2 (%) = 16 + (44 * HA<\/jats:styled-content> use before CI<\/jats:styled-content>2 (yes)) \u2212 (0.22 * length of hearing loss before CI<\/jats:styled-content>2 (years)) + (0.23 * CNC<\/jats:styled-content> phoneme score with CI<\/jats:styled-content>1 (%)). Because the effect of HA<\/jats:styled-content> use before implantation played such a major role, we also created a model after exclusion of the HA<\/jats:styled-content> factor: Predicted CNC<\/jats:styled-content> phoneme score with CI<\/jats:styled-content>2 (%) = 82 \u2212 (0.17 * length of hearing loss before CI<\/jats:styled-content>2 (years)) \u2212 (0.27 * PTA<\/jats:styled-content> in second implanted ear before CI<\/jats:styled-content>2 (0.5, 1, 2 kHz)) + (0.20 * CNC<\/jats:styled-content> phoneme score with CI<\/jats:styled-content>1 (%)).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Advanced age or a long interval between implantations does not necessarily lead to poor CI<\/jats:styled-content>2 results. Patients who are successful HA<\/jats:styled-content> users before CI<\/jats:styled-content>2, who have a low PTA<\/jats:styled-content> before CI<\/jats:styled-content>2, a high CNC<\/jats:styled-content> phoneme score with CI<\/jats:styled-content>1 and a limited length of hearing loss before CI<\/jats:styled-content>2, are likely to be successful CI<\/jats:styled-content>2 recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/coa.13193","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T09:40:55Z","timestamp":1531993255000},"page":"1500-1507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Predicting sequential bilateral cochlear implantation performance in postlingually deafened adults; A retrospective cohort study"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-6522","authenticated-orcid":false,"given":"Yvette E.","family":"Smulders","sequence":"first","affiliation":[{"name":"Ear Science Institute Australia Subiaco Western Australia Australia"},{"name":"Sir Charles Gairdner Hospital Nedlands Western Australia Australia"},{"name":"Ear Sciences Centre The University of Western Australia Nedlands Western Australia Australia"},{"name":"Department of Otorhinolaryngology Rivas Zorggroep Gorinchem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital Nedlands Western Australia Australia"},{"name":"Ear Sciences Centre The University of Western Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Stegeman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck surgery University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Eikelboom","sequence":"additional","affiliation":[{"name":"Ear Science Institute Australia Subiaco Western Australia Australia"},{"name":"Sir Charles Gairdner Hospital Nedlands Western Australia Australia"},{"name":"Ear Sciences Centre The University of Western Australia Nedlands Western Australia Australia"},{"name":"Department of Speech\u2010Language Pathology and Audiology University of Pretoria Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Sucher","sequence":"additional","affiliation":[{"name":"Ear Science Institute Australia Subiaco Western Australia Australia"},{"name":"Ear Sciences Centre The University of Western Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Upson","sequence":"additional","affiliation":[{"name":"Ear Science Institute Australia 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Internal bores, generated by nonlinear internal waves, can help mitigate this stress by delivering cooler, nutrient\u2010rich water to shallow reefs (<\u200920\u2009m). Between October 2023 and April 2024, a field experiment at Mermaid Reef Atoll (Australia's North West) examined how these bores influence reef temperature. Moored instruments on the windward side recorded tidally driven bores advecting cooler offshore waters onto the forereef slope (17\u201340\u2009m), causing rapid cooling of up to 6.9\u00b0C in 30\u2009min. Some cold\u2010water pulses crossed the reef crest, cooling the shallow reef flat (<\u20098\u2009m) by up to 4.4\u00b0C for minutes to hours. A heat budget analysis indicates that without internal bores, shallow reefs experience up to three times more heat advection, increasing bleaching risk. These findings highlight internal bores' critical role in reducing thermal stress and enhancing coral reef resilience under climate change.<\/jats:p>","DOI":"10.1002\/lol2.70094","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T13:15:38Z","timestamp":1769174138000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thermal buffering by tidally generated internal bores on the shallows of a remote coral atoll"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2583-3829","authenticated-orcid":false,"given":"C. 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Thus, swallowed fluids elicit differing physiological responses due to their shear\u2010thinning profile.<\/jats:p><\/jats:sec>Methods<\/jats:title>Two hydrocolloid fluids, xanthan gum (XG) and sodium carboxymethylcellulose gum (CMC), were compared in 10 healthy adults (mean age 39\u2009years). Manometry swallowing assessments were performed using an 8\u2010French catheter. Swallows were analyzed using the Swallow Gateway web application (www.swallowgateway.com<\/jats:ext-link>). Grouped data were analyzed by a mixed statistical model. The coefficient of determination (r<\/jats:italic>2<\/jats:sup>) assessed the relationship between measures and bolus viscosity (SI units, mPa.s) at shear rates of 1\u20141000\u2009s\u22121<\/jats:sup>.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Rheology confirmed that the thickened fluids had similar viscosities at 50\u2009s\u22121<\/jats:sup> shear rate (XG IDDSI Level\u20101, 2, and 3 respectively, 74.3, 161.2, and 399.6\u2009mPa.s vs. CMC Level\u20101, 2, and 3 respectively 78.0, 176.5, and 429.2\u2009mPa.s). However, at 300\u2009s\u22121<\/jats:sup> shear, CMC\u2010thickened fluids exhibited approximately double the viscosity (XG Level\u20101, 2, and 3 respectively 19.5, 34.4, and 84.8\u2009mPa.s vs. CMC Level\u20101, 2, and 3 respectively, 41.3, 80.8, and 160.2\u2009mPa.s). In\u00a0vivo swallows of CMC, when compared to XG, showed evidence of greater flow resistance, such as increased intrabolus pressure (p<\/jats:italic>\u2009<\u20090.01) and UES Integrated Relaxation Pressure (UESIRP, p<\/jats:italic>\u2009<\u20090.01) and shorter UES Relaxation Time (p<\/jats:italic>\u2009<\u20090.05) and Bolus Presence Time (p<\/jats:italic>\u2009<\u20090.001). The apparent fluid viscosity (mPa.s) correlated most significantly with increasing UESIRP (r<\/jats:italic>2<\/jats:sup> 0.69 at 50 s\u22121<\/jats:sup> and r<\/jats:italic>2<\/jats:sup> 0.97 at 300\u2009s\u22121<\/jats:sup>, p<\/jats:italic>\u2009<\u20090.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Fluids with divergent shear viscosities demonstrated differences in pharyngeal function. These physiological responses were linked to the shear viscosity and not the IDDSI level.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14988","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T12:42:39Z","timestamp":1735648959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Impact of Bolus Rheology on Physiological Swallowing Parameters Derived by Pharyngeal High\u2010Resolution Manometry Impedance"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-7378","authenticated-orcid":false,"given":"T.","family":"Omari","sequence":"first","affiliation":[{"name":"Flinders University Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ross","sequence":"additional","affiliation":[{"name":"Trisco Foods Carole Park Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Schar","sequence":"additional","affiliation":[{"name":"Flinders University Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Flinders University Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Flinders University Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Hawkins Watts Australia Mulgrave Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Farahani","sequence":"additional","affiliation":[{"name":"Hawkins Watts Australia Mulgrave Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cock","sequence":"additional","affiliation":[{"name":"Flinders University Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Mossel","sequence":"additional","affiliation":[{"name":"Trisco Foods Carole Park Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S107750"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03118.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061873"},{"key":"e_1_2_10_5_1","first-page":"1","article-title":"Rheological Issues on Oropharyngeal Dysphagia","volume":"38","author":"Gallegos C.","year":"2021","journal-title":"Dysphagia"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2006.04.022"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2018.01.012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-016-9758-y"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14235028"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-019-10023-y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00270.2020"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29987"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fhfh.2021.100038"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fhfh.2023.100140"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotri.2019.02.002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2008.05.007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-014-9541-x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14461"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894\u2010017\u20100552\u20102"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.21037\/ajo\u201022\u201037"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/aid2.13401"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2018.05.043"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2019.05.040"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/2050571X.2018.1535564"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26820"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00541.2004"},{"issue":"6","key":"e_1_2_10_27_1","first-page":"9","article-title":"Effects of Rheological Factors on Perceived Ease of Swallowing","volume":"25","author":"Nystr\u00f6m M.","year":"2015","journal-title":"Applied Rheology"}],"container-title":["Neurogastroenterology & Motility"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T15:51:01Z","timestamp":1744645861000},"score":7.6044655,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14988"}},"issued":{"date-parts":[[2024,12,31]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/nmo.14988"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14988","archive":["Portico"],"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"published":{"date-parts":[[2024,12,31]]},"assertion":[{"value":"2024-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14988"},{"indexed":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T16:04:15Z","timestamp":1701360255369},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T00:00:00Z","timestamp":1382918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>The prevalence of reported doctor\u2010diagnosed \u2018asthma\u2019 increased between 1990 and 2005\u20132007 in B<\/jats:styled-content>usselton, W<\/jats:styled-content>estern A<\/jats:styled-content>ustralia, accompanied by increased reported cough and phlegm but not recent wheeze. Possible reasons for the increase in diagnosed asthma include environmental exposures and diagnostic transfer. The aim of this study was to relate subject characteristics and exposures to the presence of wheeze and\/or current cough\/phlegm in the 2005\u20132007 survey.<\/jats:p><\/jats:sec>Methods<\/jats:title>A gender\u2010 and age\u2010stratified random sample of 2862 adults from the Busselton shire completed questionnaires regarding doctor\u2010diagnosed asthma, respiratory symptoms and environmental exposures; and measures of anthropometry, spirometry, exhaled nitric oxide (eNO<\/jats:styled-content>), airway hyperresponsiveness (AHR<\/jats:styled-content>) and atopy. Associations between respiratory symptoms and subject characteristics were assessed in 2656 subjects.<\/jats:p><\/jats:sec>Results<\/jats:title>Wheeze was reported by 23% of subjects, cough\/phlegm by 22% and both by 9%. The significant and independent correlates of wheeze were reflux symptoms, lung function, AHR<\/jats:styled-content>, eNO<\/jats:styled-content>, atopy, body mass index and smoking. The significant and independent correlates of cough\/phlegm were reflux symptoms, lung function, smoking and dusty job. Subjects more likely to report only wheeze than only cough\/phlegm were female, aged <40 years, atopic, had lower percentage predicted forced expiratory volume in one second (FEV1<\/jats:sub><\/jats:styled-content>) or higher percentage predicted force vital capacity.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>A variety of risk factors was associated with wheeze or cough\/phlegm or both. Increased non\u2010allergic exposures may account for increased prevalence of reported cough and phlegm and may contribute to increased reported asthma in adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12147","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T09:15:50Z","timestamp":1372151750000},"page":"1256-1260","source":"Crossref","is-referenced-by-count":11,"title":["Risk factors for respiratory symptoms in adults: The B<\/scp>usselton H<\/scp>ealth S<\/scp>tudy"],"prefix":"10.1111","volume":"18","author":[{"given":"Alan L.","family":"James","sequence":"first","affiliation":[{"name":"Department of Pulmonary Physiology and Sleep Medicine West Australian Sleep Disorders Research Institute University of Western Australia Perth Western Australia Australia"},{"name":"Busselton Population Medical Research Institute University of Western Australia Perth Western Australia Australia"},{"name":"School of Medicine and Pharmacology University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew W.","family":"Knuiman","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark L.","family":"Divitini","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennie","family":"Hui","sequence":"additional","affiliation":[{"name":"Busselton Population Medical Research Institute University of Western Australia Perth Western Australia Australia"},{"name":"PathWest Laboratory of Western Australia University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Busselton Population Medical Research Institute University of Western Australia Perth Western Australia Australia"},{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siobhain A.","family":"Mulrennan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. W. \u2018Bill\u2019","family":"Musk","sequence":"additional","affiliation":[{"name":"Busselton Population Medical Research Institute University of Western Australia Perth Western Australia Australia"},{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital University of Western Australia Perth Western Australia Australia"},{"name":"School of Medicine and Pharmacology University of Western Australia Perth Western Australia Australia"},{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)92507-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-230OC"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00194308"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a120965"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra054308"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.114993"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.94.07101805"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.065805"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.061358"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7040.1195"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200311-1575SO"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9712108"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-710ST"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201109-1640OC"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032158"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197410102911503"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2005.01611.x"},{"key":"e_1_2_7_20_1","volume-title":"Asthma in Australia 2011","author":"Marks G","year":"2011"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11679-5"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043596"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02344.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.4.9806052"}],"container-title":["Respirology"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.12147","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.12147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T09:00:56Z","timestamp":1696150856000},"score":7.6040344,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.12147"}},"issued":{"date-parts":[[2013,10,28]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/resp.12147"],"URL":"https:\/\/doi.org\/10.1111\/resp.12147","archive":["Portico"],"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"published":{"date-parts":[[2013,10,28]]}},{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T16:23:13Z","timestamp":1649002993485},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T00:00:00Z","timestamp":1609545600000},"content-version":"vor","delay-in-days":93,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2020,12,31]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Influenza season started in April, earlier than any previous season. WA immunization registry showed a higher than average vaccine uptake. By October 22,770 cases and 80 influenza related deaths were recorded (in 2018: 3,679 cases and 13 deaths). We aimed to characterize clinical presentation and outcomes of laboratory confirmed Influenza, comparing vaccinated with unvaccinated controls.Hypothesis; vaccination would result in less severe disease and better outcomes. Primary objective: length of stay (LOS); Secondary objective: prevalence of severe respiratory illness, ICU admission and death.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Retrospective study, April to October 2019. Eligible patients had a telephone-based questionnaire for clinical and immunization data verification. Excluded; &lt; 18 years; deceased; dementia; nursing home and unable to consent. Continuous and categorical data of cases (vaccinated) and controls (unvaccinated) were compared using Mann-Whitney U test (non parametric), student t-test (parametric). Correlation and multilinear regression analyses were undertaken to determine the effects of vaccination status and identified confounders on the primary outcome. Based on previous average LOS (5 days, SD 1.5) the sample required to detect a difference of 1 day with 80% power was 70 patients. This study was approved by the SJGHC HREC.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 163 eligible, 83 completed the questionnaire. 8 were excluded. 75 underwent analysis (50 vaccinated and 25 unvaccinated). Median age was 75 (23-83) and 63 (33-70) respectively (p&lt; 0.01). 76% vs 48% reported &gt;1 comorbidity (p =0.02). 10% vs 0% were admitted to ICU (p =0.16). Higher vaccination uptake was seen in older patients and those with comorbid conditions. There was a strong correlation (Spearman r= 0.54 (0.34 to 0.68, p&lt; 0.001) between age and length of stay, but none was found between comorbidity or vaccination and length of stay. Neither age (p &gt;0.05), comorbidity status (yes\/no; p=0.99), vaccination status (p=0.61) nor any combination of these variables were significantly associated with a dichotomised outcome of acute hospital stay &gt; 3 days.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Vaccination with the 2019 influenza vaccine had no significant effect on hospital length of stay, mortality or critical care requirement in patients admitted to hospital with influenza.<\/jats:p>\n <\/jats:sec>\n \n Disclosures<\/jats:title>\n All Authors: No reported disclosures<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ofid\/ofaa439.1698","type":"journal-article","created":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T08:05:42Z","timestamp":1609574742000},"page":"S761-S761","source":"Crossref","is-referenced-by-count":0,"title":["1517. 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Therapy"],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4161\/15384047.2014.956605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T17:56:00Z","timestamp":1689616560000},"score":7.6033287,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4161\/15384047.2014.956605"}},"issued":{"date-parts":[[2014,11,2]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11,2]]}},"alternative-id":["10.4161\/15384047.2014.956605"],"URL":"https:\/\/doi.org\/10.4161\/15384047.2014.956605","ISSN":["1538-4047","1555-8576"],"issn-type":[{"value":"1538-4047","type":"print"},{"value":"1555-8576","type":"electronic"}],"published":{"date-parts":[[2014,11,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & 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Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002253471602509X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002253471602509X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2016.02.2221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:30:06Z","timestamp":1651210206000},"score":7.603231,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2016.02.2221"}},"issued":{"date-parts":[[2016,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1016\/j.juro.2016.02.2221"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2016.02.2221","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2016,4]]}},{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:12:26Z","timestamp":1778742746081,"version":"3.51.4"},"reference-count":0,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"SUPP_4","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":["boneandjoint.org.uk"],"crossmark-restriction":true},"short-container-title":["Bone Joint J"],"published-print":{"date-parts":[[2026,5,14]]},"abstract":"Acetabular defects can be managed with hemispherical shells with\/without modular porous augments. Modified acetabular components serve the purpose of augments however allow for orthogonal screw placement. We report the clinical and radiographic outcomes of intra-operatively modified tantalum acetabular components for large acetabular defects. Eighty-five revisions (82 patients) with minimum 2-years follow-up were reviewed since 2013: Paprosky 2A (2), Paprosky 2B (9), Paprosky 2C (14), Paprosky 3A (36), and Paprosky 3B (24) defects; chronic pelvic discontinuity (CPD) 36 (42.3%). Proximal component translation >3mm, measured with EBRA, was used to diagnose loosening.<\/jats:p>\n Two components (2.4%) migrated >3mm, and both occurred within the first 24 months. The first mechanical failure occurred before the 8-weeks post-operative follow-up between the tantalum cup and tantalum femoral cone used to reconstruct the ischium; there was inadequate cement and no intercomponent screw was utilized. Despite the acetabular component migration from the ischium, the acetabular component appears osseointegrated to the ilium in this case with CPD.<\/jats:p>\n Six acetabular components (7%) were revised or partially revised: 1 (1.1%) for the above mechanical failure; 2 (2.2%) for periprosthetic joint infection; 1 for recurrent instability (a partial revision where the superior acetabular component osseointegrated to the ilium was preserved, but the inferior component loosened from the ischium and was revised; 1 for a periprosthetic acetabular fracture; and 1 in a patient with chronic pain and an RSA measurement of proximal cup migration greater than 1mm. In the last case, grade 1 loosening (fluid egress between the cup and ischium) was identified.<\/jats:p>\n Revision of large acetabular defects with intra-operatively modified tantalum components show promising results.<\/jats:p>","DOI":"10.1302\/1358-992x.2026.4.076","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:43:48Z","timestamp":1778741028000},"page":"76-76","update-policy":"https:\/\/doi.org\/10.1302\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["MODIFIED TANTALUM ACETABULAR COMPONENTS FOR REVISION OF LARGE ACETABULAR DEFECTS: EARLY TO MID-TERM RADIOLOGICAL OUTCOMES"],"prefix":"10.1302","volume":"108-B","author":[{"given":"LB","family":"Solomon","sequence":"first","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"D'Apolonio","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Oteman","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JM","family":"Abrahams","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NP","family":"Sheth","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SA","family":"Callary","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"42","published-online":{"date-parts":[[2026,5,14]]},"container-title":["Orthopaedic Proceedings"],"language":"en","link":[{"URL":"https:\/\/boneandjoint.org.uk\/doi\/10.1302\/1358-992X.2026.4.076\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/boneandjoint.org.uk\/doi\/10.1302\/1358-992X.2026.4.076\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/boneandjoint.org.uk\/doi\/pdf\/10.1302\/1358-992X.2026.4.076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:43:54Z","timestamp":1778741034000},"score":7.603231,"resource":{"primary":{"URL":"https:\/\/boneandjoint.org.uk\/doi\/10.1302\/1358-992X.2026.4.076"}},"issued":{"date-parts":[[2026,5,14]]},"references-count":0,"journal-issue":{"issue":"SUPP_4","published-online":{"date-parts":[[2026,5,14]]},"published-print":{"date-parts":[[2026,5,14]]}},"alternative-id":["10.1302\/1358-992X.2026.4.076"],"URL":"https:\/\/doi.org\/10.1302\/1358-992x.2026.4.076","ISSN":["1358-992X","2049-4416"],"issn-type":[{"value":"1358-992X","type":"print"},{"value":"2049-4416","type":"electronic"}],"published":{"date-parts":[[2026,5,14]]},"assertion":[{"value":"2026-5-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:52:26Z","timestamp":1788630746996,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2023,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The frequency of oxycodone adverse reactions, subsequent opioid prescription, effect on pain and patient care in general surgery patients are not well known. This study aimed to determine prevalence of documented oxycodone allergy and intolerances (independent variables) in a general surgical cohort, and association with prescribing other analgesics (particularly opioids), subjective pain scores, and length of hospital stay (dependent variables).<\/jats:p><\/jats:sec>Methods<\/jats:title>This retrospective cohort study included general surgery patients from two South Australian hospitals between April 2020 and March 2022. Multivariable logistic regression evaluated associations between previous oxycodone allergies and intolerances, prescription records, subjective pain scores, and length of hospital stay.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 12\u2009846 patients, 216 (1.7%) had oxycodone allergies, and 84 (0.7%) oxycodone intolerances. The 216 oxycodone allergy patients had lower odds of receiving oxycodone (OR 0.17, P<\/jats:italic>\u2009<\u20090.001), higher odds of tramadol (OR 3.01, P<\/jats:italic>\u2009<\u20090.001) and tapentadol (OR 2.87, P<\/jats:italic>\u2009=\u20090.001), but 91 (42.3%) still received oxycodone and 19 (8.8%) morphine. The 84 with oxycodone intolerance patients had lower odds of receiving oxycodone (OR 0.23, P<\/jats:italic>\u2009<\u20090.001), higher odds of fentanyl (OR 3.6, P<\/jats:italic>\u2009<\u20090.001) and tramadol (OR 3.35, P<\/jats:italic>\u2009<\u20090.001), but 42 (50%) still received oxycodone. Patients with oxycodone allergies and intolerances had higher odds of elevated subjective pain (OR 1.60, P<\/jats:italic>\u2009=\u20090.013; OR 2.36, P<\/jats:italic>\u2009=\u20090.002, respectively) and longer length of stay (OR 1.36, P<\/jats:italic>\u2009=\u20090.038; OR 2.24, P<\/jats:italic>\u2009=\u20090.002, respectively) than patients without these.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>General surgery patients with oxycodone allergies and intolerances are at greater risk of worse postoperative pain and longer length of stay, compared to patients without. Many still receive oxycodone, and other opioids that could cause cross\u2010reactivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18722","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T05:52:15Z","timestamp":1697262735000},"page":"2631-2637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Opioid prescribing, pain, and hospital stay of general surgery patients with oxycodone allergies in South Australia"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3880-3840","authenticated-orcid":false,"given":"Joshua G.","family":"Kovoor","sequence":"first","affiliation":[{"name":"Discipline of Surgery, The Queen Elizabeth Hospital University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Australasian College of Surgeons Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Bacchi","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Flinders Medical Centre Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-0378","authenticated-orcid":false,"given":"Aashray K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Gold Coast University Hospital Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy","family":"Vo","sequence":"additional","affiliation":[{"name":"Flinders Medical Centre Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Lam","sequence":"additional","affiliation":[{"name":"Flinders Medical Centre Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Lam","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Jiang","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-3489","authenticated-orcid":false,"given":"Brandon","family":"Stretton","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh\u2010Son","family":"To","sequence":"additional","affiliation":[{"name":"Flinders Medical Centre Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5264-1115","authenticated-orcid":false,"given":"Silas","family":"Nann","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8075-7852","authenticated-orcid":false,"given":"Christopher D.","family":"Ovenden","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-4554","authenticated-orcid":false,"given":"Joseph N.","family":"Hewitt","sequence":"additional","affiliation":[{"name":"Discipline of Surgery, The Queen Elizabeth Hospital University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudy","family":"Goh","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8066-7259","authenticated-orcid":false,"given":"Jessica L.","family":"Reid","sequence":"additional","affiliation":[{"name":"Discipline of Surgery, The Queen Elizabeth Hospital University of Adelaide Adelaide South Australia 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Telepractice additionally addresses a national digital health strategic plan for accessible digitally enabled models of care. To plan improvements, it is essential to understand the experience of telepractice for people with disability, which may be achieved through an approach such as journey mapping. The current article provides both a disability\u2010specific case study and a methodological guide for the inclusion of customers and clinicians in the meaningful redevelopment of services. The Perth, Australia\u2010based case study aimed to gain insights into the experience of telepractice for people with disability. The methodological aim describes using co\u2010design to produce a journey map in collaboration with customers and clinicians, for potential replication in a wide range of health and social care contexts.<\/jats:p><\/jats:sec>Method<\/jats:title>Interview transcripts gathered from a cohort of customer participants (n<\/jats:italic>\u2009=\u200917) were used to inform the journey map. A group of customers (n<\/jats:italic>\u2009=\u20095) and clinicians plus one manager (n<\/jats:italic>\u2009=\u20095) distributed the findings onto a customer experience journey map during a co\u2010design workshop. The journey map describes the emotional experience and actions taken, along five phases of a timeline through telepractice service interactions: (1) before, (2) selecting telepractice, (3) telepractice preparation, (4) during telepractice sessions and (5) after.<\/jats:p><\/jats:sec>Results<\/jats:title>A journey map visualisation of customer experiences was produced that identified strengths of telepractice service delivery (flexibility) while noting challenges (with technology) as opportunities for improvement. The consensus of participants was the desire to have access to telepractice currently and in the future, in addition to in\u2010person delivery.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These findings are valuable in the context of advocating for the incorporation of customers and clinicians through co\u2010design workshops in the content analysis and creation of a journey map that is representative of the lived experience of accessing telepractice services.<\/jats:p><\/jats:sec>Patient or Public Contribution<\/jats:title>The paper forms part of a larger co\u2010design process that included customer participants throughout the design and planning of the project, inclusion of a peer researcher and the co\u2010designers in the workshops, journey map and this article production.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hex.13919","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T18:47:06Z","timestamp":1700765226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Co\u2010designing a telepractice journey map with disability customers and clinicians: Partnering with users to understand challenges from their perspective"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6950-8855","authenticated-orcid":false,"given":"Cloe","family":"Benz","sequence":"first","affiliation":[{"name":"School of Population Health Curtin University Bentley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Scott\u2010Jeffs","sequence":"additional","affiliation":[{"name":"Rocky Bay Mosman Park Western Australia 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Language Guide: A Guide to Language About Disability","author":"People with Disability Australia","year":"2021"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACM.0000000000000388"},{"key":"e_1_2_11_25_1","volume-title":"When to Use What Research Design","author":"Vogt WP","year":"2012"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-065600"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjpt.2022.100445"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000001771"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3233\/WOR-210789"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13687"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez068"},{"key":"e_1_2_11_32_1","volume-title":"Convention on the Rights of Persons with Disabilities (CRPD)","author":"United Nations Department of Economic and Social Affairs","year":"2006"},{"key":"e_1_2_11_33_1","volume-title":"Qualitative Research Practice: A Guide for Social Science Students and Researchers","author":"Ritchie J","year":"2014"}],"container-title":["Health Expectations"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hex.13919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T12:09:45Z","timestamp":1755950985000},"score":7.601826,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hex.13919"}},"issued":{"date-parts":[[2023,11,21]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/hex.13919"],"URL":"https:\/\/doi.org\/10.1111\/hex.13919","archive":["Portico"],"ISSN":["1369-6513","1369-7625"],"issn-type":[{"value":"1369-6513","type":"print"},{"value":"1369-7625","type":"electronic"}],"published":{"date-parts":[[2023,11,21]]},"assertion":[{"value":"2023-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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components within behavioral sleep interventions in school-aged children with ADHD and examine evidence related to effectiveness.<\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n \n A systematic review was conducted using PsycINFO, Embase, MEDLINE, PubMed, and OpenGray. The subsequent meta-analysis used sleep outcomes to produce comparable effect sizes (Hedges\u2019\n g<\/jats:italic>\n ) and compare intervention effects between randomized controlled trials and pre-post studies.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Eleven articles satisfied the inclusion criteria (562 children, across all groups, aged 5\u201314\u2009years,\n M<\/jats:italic>\n \u2009=\u20098.71). Studies reported improvements in sleep although there was marked heterogeneity between studies and limited use of objective sleep measures within them. On average, intervention groups improved more than control groups in the five randomized controlled trials (\u22120.46, 95% CI\u2009=\u2009[\u22120.58, \u22120.35],\n k<\/jats:italic>\n \u2009=\u20094).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The findings support the use of behavioral sleep interventions for school-aged children with ADHD. Findings suggest that brief, individualized intervention may be more effective than standardized.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10870547221106239","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T06:19:44Z","timestamp":1656137984000},"page":"1805-1821","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Behavioral Sleep Interventions for Children With ADHD: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9507-8529","authenticated-orcid":false,"given":"Maya K.","family":"Malkani","sequence":"first","affiliation":[{"name":"University Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela F.","family":"Pestell","sequence":"additional","affiliation":[{"name":"University Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M. 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For stage II (SII) disease, the selection of patients for adjuvant treatment remains controversial. There remains limited data on clinician decision making regarding adjuvant chemotherapy in routine clinical practice. Methods: A review of patients treated with SII & IIICC at 4 hospitals, utilising data from BioGrid Australia, where clinician choice and rationale were prospectively documented. Results: 372 patients (37%) with SII and 307 (30%) with SIIICC were identified from 1015 CC patients treated from January 2003 till November 2008. Median age was 68 years, 51% were male; 49% female. 66 (25%) of patients with SIIICC were not offered chemotherapy, predominantly due to advanced age or co-morbidity. Since oxaliplatin and capecitabine became widely available in 2005, 66% of treated patients have received oxaliplatin based therapy, 15% bolus 5-FU alone and 19% capecitabine. For SII disease, overall 81 (26%) pts received adjuvant chemotherapy. Age was the dominant influence on treatment choice with 41% aged 70 (p<0.001) receiving treatment. Patients with high risk features were also more likely to receive adjuvant therapy. (p= 0.006 for those with lymphovascular invasion and p= 0.0068 for those with T4 tumours). Dose reductions and completion rates were similar for SII and III disease, and for older and younger patients. Conclusions: Over 25% of patients with SIIICC do not receive adjuvant chemotherapy in routine practice, with physicians basing non-treatment recommendations predominantly on patient age and co-morbidity. Where treatment is used, oxaliplatin-based therapy is the dominant regimen, except in older patients. 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Twenty-nine recreational and competitive male surfers were assessed for height, mass, relative arm span, relative seated height, relative biacromial width, and skinfolds (Sum7). The upper extremity strength variables assessed were the relative 1RM pull up and 1RM dip. The surfboard paddling variables assessed were a 15\u2009m sprint-paddling test and a 400\u2009m endurance-paddling water-based test. Pearson correlation analysis and independent t-tests were used to compare differences between groups and determine the significant correlations between variables. Sum7 and relative arm span were correlated with speed in all paddling efforts meanwhile the sprint-paddling ability was correlated with the upper extremity strength. Significant differences between competitive and recreational surfers exist in relative arm span and endurance paddle performance. The strong relationships between the physical variables can be used by sports coaches and support staff to influence talent identification, training, and nutrition programs.<\/jats:p>","DOI":"10.1177\/1747954116667111","type":"journal-article","created":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T20:48:24Z","timestamp":1473108504000},"page":"728-735","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Association between anthropometry, upper extremity strength, and sprint and endurance paddling performance in competitive and recreational surfers"],"prefix":"10.1177","volume":"11","author":[{"given":"Joseph OC","family":"Coyne","sequence":"first","affiliation":[{"name":"Surfing Australia High Performance Centre, Australia"},{"name":"Edith Cowan University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai T","family":"Tran","sequence":"additional","affiliation":[{"name":"Surfing Australia High Performance Centre, Australia"},{"name":"Edith Cowan University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh L","family":"Secomb","sequence":"additional","affiliation":[{"name":"Surfing Australia High Performance Centre, Australia"},{"name":"Edith Cowan University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Surfing Australia High Performance Centre, Australia"},{"name":"Edith Cowan University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver RL","family":"Farley","sequence":"additional","affiliation":[{"name":"Surfing Australia High Performance Centre, Australia"},{"name":"Edith Cowan University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert U","family":"Newton","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M","family":"Sheppard","sequence":"additional","affiliation":[{"name":"Surfing Australia High Performance Centre, Australia"},{"name":"Edith Cowan University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,9,19]]},"reference":[{"key":"bibr1-1747954116667111","first-page":"70","volume":"20","author":"Meir R","year":"1991","journal-title":"Aust J Sci Med Sport"},{"key":"bibr2-1747954116667111","first-page":"477","volume":"20","author":"Mendez-Villanueva A","year":"2006","journal-title":"J Strength Cond Res"},{"key":"bibr3-1747954116667111","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e3182392c4b"},{"key":"bibr4-1747954116667111","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200535010-00005"},{"key":"bibr5-1747954116667111","unstructured":"Sheppard J. 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FASD Employment Services\/Criminal Justice Grant GO2652","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,2,7]]},"published-print":{"date-parts":[[2023,2]]},"abstract":"\n Objectives<\/jats:title>\n Individuals with fetal alcohol spectrum disorder (FASD) are over-represented within the justice system and have significant employment challenges. The primary aim of this scoping review was to ascertain available employment resources for FASD individuals particularly those involved in the justice system. Secondary aims were to determine available evidence-based interventions for the justice workforce and employment providers.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Eligibility criteria<\/jats:italic>\n : That the resource was (a) published between 1990 and 2021, (b) in English, (c) available electronically in full text, (d) focused on strategies for improving employment outcomes of individuals with FASD and (f) developed for those aged over 15.\n Sources of evidence:<\/jats:italic>\n Electronic searches of the following databases were conducted: EMBASE, MEDLINE, PsycINFO, Scopus, Web of Science and Google Scholar. Grey literature was collected via the databases ProQuest Dissertations & Theses Global, OpenGrey, GreyNet International and Grey Matters.\n Charting methods:<\/jats:italic>\n Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews reporting guidelines, a five-stage methodological framework was employed. A quality appraisal of identified resources was conducted. Data were summarised qualitatively using a content analysis method that allowed for analysis of specific terms\/themes\/concepts\/resource elements that resources covered, as well as a quantitative analysis of their frequency.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n An initial search identified 850 articles, 512 of which were obtained through online database searches, 321 through Google Scholar searches and 17 through google searches. Sixteen resources were identified as meeting inclusion criteria, including four peer-reviewed papers and 12 grey literature resources. Six of the resources extracted were deemed \u2018good\u2019 or \u2018strong\u2019 quality, with the remainder\u2014all grey literature resources\u2014being \u2018adequate\u2019 or \u2018limited\u2019. None of the resources identified were empirically evaluated or could be implemented synergistically. Content analysis revealed common themes addressing FASD-related employment challenges and required supports.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This review highlights the need for developing evidence-based employment-related resources for justice-involved people with FASD. Most of the 16 identified resources had a psychoeducational and advocacy component and described typical employment challenges with specific supports and accommodations to maximise workforce participation. However, none had been empirically evaluated, underscoring the importance of future research in this area to better inform more responsive and evidence-based employment-related programmes.<\/jats:p>\n <\/jats:sec>\n \n Trial registration number<\/jats:title>\n doi:10.17605\/OSF.IO\/J5VMB.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-063860","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T10:06:29Z","timestamp":1676628389000},"page":"e063860","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Scoping review of employment resources for individuals with fetal alcohol spectrum disorder and justice involvement"],"prefix":"10.1136","volume":"13","author":[{"given":"Marie M A","family":"Nankoo","sequence":"first","affiliation":[{"name":"School of Psychological Science, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Patches Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten R","family":"Panton","sequence":"additional","affiliation":[{"name":"School of Psychological Science, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"School of Psychological Science, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Patches Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1737-7774","authenticated-orcid":false,"given":"Carmela F","family":"Pestell","sequence":"additional","affiliation":[{"name":"School of Psychological Science, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"2025121406545373000_13.2.e063860.1","unstructured":"Streissguth AP . 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There is an accumulating body of evidence to suggest that apoB-48 plays a central role in the development of atherosclerosis. Statins are the frontline therapy to reduce cardiovascular risk, however, a large residual risk still remains. This residual risk suggests that additional therapeutic interventions may be required to further reduce CVD risk.\n <\/jats:p>\n \n Aim:<\/jats:bold>\n To investigate the effect of niacin on the metabolism of triglyceride-rich lipoprotein (TRL) apoB-48 in men with type 2 diabetes on background statin therapy.\n <\/jats:p>\n \n Methods:<\/jats:bold>\n Twelve type 2 diabetic men were recruited for this randomized, cross-over design study. Patients required a statin-treated low density lipoprotein (LDL) cholesterol of less than 2.5 mmol\/L to enter the trial. Patients were then randomized to rosuvastatin alone or rosuvastatin plus niacin (titrated up from 1 to 2 g daily) for a period of 12 weeks and then were crossed over to the alternate therapy with a 3 week washout period in between. Metabolic studies were performed at the end of each treatment period. A bolus intravenous infusion of D3-leucine was administered as subjects consumed a standardised high-fat liquid meal. Blood samples were collected over 24 hours and TRL apoB-48 tracer\/tracee ratios were measured using gas chromatography-mass spectrometry. Kinetic parameters, including fractional catabolic rate (FCR) and production rate (PR), were derived using a multicompartmental model.\n <\/jats:p>\n \n Results:<\/jats:bold>\n Niacin significantly reduced triglyceride, plasma cholesterol, LDL cholesterol and apoB (all p<0.005). TRL apoB-48 concentration was lower with niacin (8.24 \u00b1 1.98 vs 5.48 \u00b1 1.14 mg\/L, p=0.03). ApoB-48 FCR was not altered with niacin (8.78 \u00b1 1.04 vs 9.17 \u00b1 1.26 pools\/day; p=0.79). Basal apoB-48 PR (3.21 \u00b1 0.34 vs 2.50 \u00b1 0.31 mg\/kg\/day; p=0.04) and postprandial apoB-48 PR were significantly lower (1.35 \u00b1 0.19 vs 0.84 \u00b1 0.12 mg\/kg; p=0.02) on niacin.\n <\/jats:p>\n \n Conclusion:<\/jats:bold>\n Niacin reduces TRL apoB-48 concentration by lowering basal and postprandial apoB-48 PR. This effect on apoB-48 metabolism may be beneficial for reducing atherogenic postprandial TRL particles and may provide CVD risk benefit to patients with type 2 diabetes.\n <\/jats:p>","DOI":"10.1161\/circ.129.suppl_1.p270","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T04:09:29Z","timestamp":1625285369000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract P270: Niacin Lowers Triglyceride-Rich Lipoprotein Apolipoprotein B-48 Secretion in Statin-Treated Type 2 Diabetics"],"prefix":"10.1161","volume":"129","author":[{"given":"Jing","family":"Pang","sequence":"first","affiliation":[{"name":"Univ of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick","family":"Chan","sequence":"additional","affiliation":[{"name":"Univ of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Univ of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Tenneti","sequence":"additional","affiliation":[{"name":"Univ of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Watts","sequence":"additional","affiliation":[{"name":"Univ of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Barrett","sequence":"additional","affiliation":[{"name":"Univ of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00003017-201403251-00411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T20:44:24Z","timestamp":1715633064000},"score":7.6013837,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/circ.129.suppl_1.p270"}},"issued":{"date-parts":[[2014,3,25]]},"references-count":0,"journal-issue":{"issue":"suppl_1","published-print":{"date-parts":[[2014,3,25]]}},"alternative-id":["10.1161\/circ.129.suppl_1.p270"],"URL":"https:\/\/doi.org\/10.1161\/circ.129.suppl_1.p270","ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"published":{"date-parts":[[2014,3,25]]},"assertion":[{"value":"2018-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:09:30Z","timestamp":1781924970536,"version":"3.54.5"},"reference-count":4,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T00:00:00Z","timestamp":1645315200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,2]]},"abstract":"Abstract<\/jats:title>Automated information extraction might be able to assist with the collection of stroke key performance indicators (KPI). The feasibility of using natural language processing for classification\u2010based KPI and datetime field extraction was assessed. Using free\u2010text discharge summaries, random forest models achieved high levels of performance in classification tasks (area under the receiver operator curve 0.95\u20131.00). The datetime field extraction method was successful in 29 of 43 (67.4%) cases. Further studies are indicated.<\/jats:p>","DOI":"10.1111\/imj.15678","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T01:07:02Z","timestamp":1645405622000},"page":"315-317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Automated information extraction from free\u2010text medical documents for stroke key performance indicators: a pilot study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5130-8628","authenticated-orcid":false,"given":"Stephen","family":"Bacchi","sequence":"first","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Gluck","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Koblar","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Jannes","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Kleinig","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,20]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2396987317735426"},{"key":"e_1_2_3_3_1","unstructured":"Australian Commission on Safety and Quality in Health Care.Acute Stroke Clinical Care Standard.2019."},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tacc.2021.02.007"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493015607523"}],"container-title":["Internal Medicine Journal"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.15678","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.15678","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.15678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T21:26:25Z","timestamp":1692998785000},"score":7.601219,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.15678"}},"issued":{"date-parts":[[2022,2]]},"references-count":4,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/imj.15678"],"URL":"https:\/\/doi.org\/10.1111\/imj.15678","archive":["Portico"],"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"2021-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:38:35Z","timestamp":1767177515867,"version":"build-2238731810"},"reference-count":0,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"14_suppl","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2004,7,15]]},"DOI":"10.1200\/jco.2004.22.90140.6074","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T03:17:42Z","timestamp":1491362262000},"page":"6074-6074","source":"Crossref","is-referenced-by-count":0,"title":["Satisfaction with the process of providing informed consent to cancer clinical trials"],"prefix":"10.1200","volume":"22","author":[{"given":"L. R.","family":"Mileshkin","sequence":"first","affiliation":[{"name":"Cancer Trials Australia, Melbourne, Australia; Royal Melbourne Hospital, Melbourne, Australia; Austin Hospital, Heidelberg, Australia; Peter MacCallum Cancer Centre, East Melbourne, Australia; The Western Hospital, Footscray, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Raunow","sequence":"additional","affiliation":[{"name":"Cancer Trials Australia, Melbourne, Australia; Royal Melbourne Hospital, Melbourne, Australia; Austin Hospital, Heidelberg, Australia; Peter MacCallum Cancer Centre, East Melbourne, Australia; The Western Hospital, Footscray, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Cavicchiolo","sequence":"additional","affiliation":[{"name":"Cancer Trials Australia, Melbourne, Australia; Royal Melbourne Hospital, Melbourne, Australia; Austin Hospital, Heidelberg, Australia; Peter MacCallum Cancer Centre, East Melbourne, Australia; 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Findings included a densely shadowing structure within the distal ileum with severe local muscularis thickening, mild diffuse small intestinal muscularis thickening, and an enlarged right ileocolic lymph node. Abdominal radiographs showed the structure to be most consistent with an enterolith. Enterolithiasis is a rare condition in companion animals, but common in horses and selected populations of human patients. Enterectomy was performed, and histopathology results of intestinal biopsies were consistent with chronic inflammatory enteropathy. Chemical analysis of the enterolith revealed a predominantly calcium phosphate composition. At the 3\u2010month follow\u2010up, the cat had gained weight and showed marked improvement in gastrointestinal signs. Screening for underlying structural intestinal disease may be beneficial in cats diagnosed with enteroliths.<\/jats:p>","DOI":"10.1002\/vrc2.824","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:10:02Z","timestamp":1707869402000},"source":"Crossref","is-referenced-by-count":1,"title":["Single large enterolith in a cat with chronic inflammatory enteropathy"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9322-8871","authenticated-orcid":false,"given":"Patricia","family":"Thong","sequence":"first","affiliation":[{"name":"Animalius Bayswater Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Wolfenden","sequence":"additional","affiliation":[{"name":"Animalius Bayswater Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Animalius Bayswater 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i47.17819"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/ctep.2002.35576"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2006.03.004"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1979.tb01307.x"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2009.04.010"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1999.214.02.233"},{"issue":"1","key":"e_1_2_13_8_1","first-page":"105","article-title":"Enterolithiasis in cats after over\u2010feeding with rat mash","volume":"28","author":"Kunst\u00fdr I","year":"1986","journal-title":"Z Versuchstierkd"},{"issue":"24","key":"e_1_2_13_9_1","first-page":"579","article-title":"Partial ileocaecocolic obstruction due to suspected enterolithiasis in a dog","volume":"135","author":"Pitcher GD","year":"1994","journal-title":"Vet Rec"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12758"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.333"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002610000085"},{"key":"e_1_2_13_13_1","volume-title":"Investigations into the risk factors, etiology and pathogenesis of enterolithiasis in horses (Equus callabus)","author":"Hassel 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Gastroenterol."},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i42.6160"},{"key":"e_1_2_13_24_1","first-page":"119","article-title":"Crohn's disease\u2010small bowel obstruction secondary to enterolith\u2010a case report","volume":"2","author":"Shah A","year":"2013","journal-title":"OMICS J Radiol"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2021.11.032"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/94.2.283"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S369640"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(03)00041-9"},{"key":"e_1_2_13_29_1","first-page":"651","volume-title":"Canine and feline gastroenterology","author":"Hall E","year":"2013"},{"key":"e_1_2_13_30_1","first-page":"1","article-title":"Meckel's diverticulum in animals and birds: an immuno\u2010pathoclinical perspective","volume":"18","author":"Gofur MR","year":"2020","journal-title":"Bangl J Vet Med"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/jfms.1999.0042"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2000.61.359"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X211062096"}],"container-title":["Veterinary Record Case 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(SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Sa\u00fade P\u00fablica"],"published-print":{"date-parts":[[2011,10]]},"abstract":"OBJECTIVE: To describe sleep, stress and compensatory behaviors in nurses and midwives. METHODS: The study included 41 midwives and 21 nurses working in Australian hospitals between 2005 and 2009. Participation was voluntary. All participants recorded on a daily basis their work and sleep hours, levels of stress and exhaustion, caffeine intake and use of sleep aids for a month (1,736 days, 1,002 work shifts). RESULTS: Participants reported moderate to high levels of stress and exhaustion on 20-40% of work days; experienced sleep disruption on more than 50% of work days; struggled to remain awake on 27% of work days; and suffered extreme drowsiness or experienced a near accident while travelling home on 9% of workdays. Age, perceived sleep duration and work hours were significant predictors of caffeine intake. About 60% of participants reported using sleep aids (about 20% reported taking prescription medications and 44% of nurses and 9% of midwives reported alcohol use as a sleep aid at least once during the study). Stress and workdays were significant predictors of sedative use. Overall, 22% reported being indifferent or mildly dissatisfied with their job. CONCLUSIONS: Sleep problems, high levels of stress and exhaustion and low job satisfaction are prevalent among nurses and midwives. The use of alcohol and sleeping pills as sleep aids, and the use of caffeine to help maintain alertness is also common. Nurses and midwives may use caffeine to compensate for reduced sleep, especially on workdays, and sleeping pills to cope with their daily work-related stress.<\/jats:p>","DOI":"10.1590\/s0034-89102011005000059","type":"journal-article","created":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T16:21:40Z","timestamp":1313079700000},"page":"922-930","source":"Crossref","is-referenced-by-count":68,"title":["Sleep, stress and compensatory behaviors in Australian nurses and midwives"],"prefix":"10.1590","volume":"45","author":[{"given":"Jillian","family":"Dorrian","sequence":"first","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Paterson","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drew","family":"Dawson","sequence":"additional","affiliation":[{"name":"University of South 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[editorial]","volume":"3","author":"Sandall J","year":"1995","journal-title":"Br J Midwifery"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4037\/ajcc2006.15.1.30","article-title":"Effects of critical care nurses' work hours on vigilance and patients' safety","volume":"15","author":"Scott LD","year":"2006","journal-title":"Am J Crit Care."},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/sleep\/30.12.1801","article-title":"The relationship between nurse work schedules, sleep duration and drowsy driving","volume":"30","author":"Scott LD","year":"2007","journal-title":"Sleep","ISSN":"https:\/\/id.crossref.org\/issn\/0161-8105","issn-type":"print"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0278-6915(02)00096-0","article-title":"Effects of caffeine on human behavior","volume":"40","author":"Smith A","year":"2002","journal-title":"Food Chem 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Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534716008788?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534716008788?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2016.02.590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T04:59:33Z","timestamp":1651208373000},"score":7.6001143,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2016.02.590"}},"issued":{"date-parts":[[2016,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1016\/j.juro.2016.02.590"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2016.02.590","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2016,4]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:47Z","timestamp":1753889867334,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"Aim: To generate pilot data regarding acceptance, safety, and function of a novel long-term CGM.<\/jats:p>\n Methods: The investigational CGM (Eclipse 3, GlySens, San Diego, CA) was surgically inserted superficial to the rectus sheath in 8 type 1 diabetes adults (4 Female; Mean [SD] age 56 [7]; BMI 25 [3]). CGM data were masked to participants and processed retrospectively in simulated real-time with one capillary blood glucose calibration per day. Monthly visits evaluated: user acceptance by standardised questionnaire; health of implantation sites; safety by anti-glucose oxidase and anti-catalase antibodies; and performance benchmarked against YSI during standardised meal tests. Bluetooth communication between the sensor and an Apple iPhone was assessed continuously.<\/jats:p>\n Results: One sensor was removed at 4 months (participant withdrawal) due to impacted implant environment. There were no SAE\u2019s. User acceptance remained high for the study duration. (Figure 1) Antibody levels did not rise. The lag corrected (23.3minutes) MARD (Median [range]) of 12.4% (1401 paired readings) was stable from month 1 (13.1%) to month 10 (14.0%). CGM readings within 20\/20% and 30\/30% of YSI values were 85% and 96%, respectively. The App received 95% of sensor data within 10 minutes.<\/jats:p>\n Conclusions: Our results provide initial data supporting participant acceptance, and safety of Eclipse 3. Further sensor refinement will reduce lag and improve performance.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n A.Butler: Employee; GlySens Incorporated. J.Tan: None. D.N.O'neal: None. L.Robinson: None. V.R.Obeyesekere: None. H.Jones: None. Y.W.Kong: None. C.Yuan: None. K.Bertsch: Employee; GlySens Inc. T.L.Routh: Employee; GlySens Incorporated. S.L.Martha: Employee; GlySens Incorporated.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-958-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:08:06Z","timestamp":1687237686000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["958-P: Feasibility of a Long-Term Implanted Continuous Glucose Monitor (CGM)"],"prefix":"10.2337","volume":"72","author":[{"given":"ANTHONY","family":"BUTLER","sequence":"first","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LESLEY","family":"ROBINSON","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VARUNI R.","family":"OBEYESEKERE","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HANNAH","family":"JONES","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YEE W.","family":"KONG","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHENG","family":"YI YUAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KRISTA","family":"BERTSCH","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIMOTHY L.","family":"ROUTH","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SANDRA L.","family":"MARTHA","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JASON","family":"TAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, San Diego, CA, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/958-P\/149125\/958-P-Feasibility-of-a-Long-Term-Implanted","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/958-P\/149125\/958-P-Feasibility-of-a-Long-Term-Implanted","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:08:07Z","timestamp":1687237687000},"score":7.600002,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/958-P\/149125\/958-P-Feasibility-of-a-Long-Term-Implanted"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-958-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"958-P"},{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:10:14Z","timestamp":1780351814192,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2025,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Older adults (\u2265\u200965\u2009years) present with complex Acute Gallstone Disease (AGD) and can deteriorate rapidly, necessitating time\u2010critical decision making. We describe AGD presentation, management, and associated outcomes in older adults.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Older adults with AGD between May 2021 and April 2022 were identified from a prospectively maintained dataset, including age, Clinical Frailty Scale (CFS) and co\u2010morbidities. Data pertaining to diagnosis, management, and outcomes (mortality, discharge destination, readmissions) were collected retrospectively.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 122 older adults with AGD, 63.1% were vulnerable or frail, 80.3% were moderately or severely co\u2010morbid, and 54.1% had Acute Calculous Cholecystitis (ACC). 43.9% were managed with antibiotics alone, 28.8% via Early Cholecystectomy (EC), 21.2% via Percutaneous Cholecystostomy (PC), 4.5% with Endoscopic Retrograde Cholangiography (ERCP), and 1.5% palliated. The EC cohort was less frail and less co\u2010morbid (CFS\u2009=\u20093, CCI\u2009=\u20093,\n p<\/jats:italic>\n \u2009=\u20090.05) compared to those managed non\u2010operatively. Inpatient mortality was 13.3% post\u2010PC and 0% post\u2010EC (\n p<\/jats:italic>\n \u2009=\u20090.03). 38.5% of those managed with antibiotics alone represented at 90\u2009days, as did 40% post\u2010PC. In contrast, post\u2010EC, 83.3% were discharged directly home, with 4.17% (\n p<\/jats:italic>\n \u2009\u2264\u20090.01) readmitted at 90\u2009days.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Older adults presenting with AGD have frailty and co\u2010morbidities, and ACC is the most frequent presentation. 28.8% of ACC was managed via EC, which was safe and effective, with >\u200980% discharged home, <\u20095% 90\u2010day readmissions, and no inpatient mortalities. Readmission was highest post PC and antibiotics. Frailty, co\u2010morbidities, procedural and anaesthetic risk, and associated clinical outcomes need to be considered when managing AGD in older adults.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ans.70268","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T09:09:03Z","timestamp":1753348143000},"page":"1750-1757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Management of Acute Gallstone Disease in Older Adults and Associated Outcomes"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1560-1162","authenticated-orcid":false,"given":"Kate","family":"Junker","sequence":"first","affiliation":[{"name":"Acute Surgical Unit Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Foster","sequence":"additional","affiliation":[{"name":"Acute Surgical Unit Fiona Stanley Hospital Perth Western Australia Australia"},{"name":"The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Acute Surgical Unit Fiona Stanley Hospital Perth Western Australia Australia"},{"name":"The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabnam","family":"Islam","sequence":"additional","affiliation":[{"name":"Acute Surgical Unit Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8917-8371","authenticated-orcid":false,"given":"Oscar","family":"Aldridge","sequence":"additional","affiliation":[{"name":"Acute Surgical Unit Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Gilliland","sequence":"additional","affiliation":[{"name":"Acute Surgical Unit Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuttara Panchali W.","family":"Kumarasinghe","sequence":"additional","affiliation":[{"name":"Acute Surgical Unit Fiona Stanley Hospital Perth Western Australia Australia"},{"name":"The University of Western Australia Perth Western Australia Australia"},{"name":"Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-3917-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k3965"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-023-02954-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2012.00610.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13304-014-0267-y"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2009.00052.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-014-3961-4"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurger.2017.04.013"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-06634-5"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2018.12.018"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2019.03.373"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-015-0361-0"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.516"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.12.026"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3375-4"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-011-2035-0"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-018-4021-5"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-5161-x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-020-05491-5"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-020-00336-x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002589"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-3144-8"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.12313"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-018-3863-1"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.19026"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.19107"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.050051"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1457496919832147"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8627(03)00072-5"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2014.12.012"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2021.0331"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.04.018"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2024.08.004"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60071040"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviscsurg.2013.01.004"}],"container-title":["ANZ Journal of Surgery"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ans.70268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:42:42Z","timestamp":1772970162000},"score":7.599946,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.70268"}},"issued":{"date-parts":[[2025,7,24]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/ans.70268"],"URL":"https:\/\/doi.org\/10.1111\/ans.70268","archive":["Portico"],"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"published":{"date-parts":[[2025,7,24]]},"assertion":[{"value":"2025-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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Dementia"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.jalz.2011.05.844","type":"journal-article","created":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T22:28:28Z","timestamp":1312237708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["O2\u201002\u201004: Impact of Dementia Subtype and Disease Staging on Carer Burden in Frontotemporal Dementia"],"prefix":"10.1002","volume":"7","author":[{"given":"Eneida","family":"Mioshi","sequence":"first","affiliation":[{"name":"Neuroscience Research Australia Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Foxe","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicity","family":"Leslie","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Sydney 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Systematic medication review and cessation of inappropriate medications or deprescribing may improve patient outcomes and reduce costs. Objective: The aim of this study was to assess the feasibility of a patient-centered deprescribing process in a population of adults with complex polypharmacy. Methods: This was a prospective feasibility study. Participants were recruited from hospital outpatient clinics. The patient-centered deprescribing process consisted of 5 steps: comprehensive medication history, identification of potentially inappropriate medications, determining if the medication can be ceased, planning the withdrawal regimen (eg, tapering where necessary), and provision of monitoring, support, and documentation. Feasibility was determined by assessing time taken to complete the different steps of the deprescribing process and participant feedback. Results: In all, 57 PPI users were recruited; participants were 70 \u00b1 14 years old and took 14 \u00b1 6 medications. The indication for PPI use was verified in 43 participants and judged as potentially inappropriate in 19 (44%); 8 were suitable for trial withdrawal, and 6 consented. All 6 successfully ceased (n = 3) or reduced (n = 3) their PPI use, and this was sustained at 6 months postintervention in 4 participants. Conclusions: The patient-centered deprescribing process can safely reduce inappropriate PPI prescribing in a small proportion of people. 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First example of glyoxylamide-based short peptides which can encapsulate organic solvents and water at relatively low concentrations.<\/p>","DOI":"10.1039\/c7nj02248d","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T23:03:03Z","timestamp":1506380583000},"page":"13462-13471","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Design, synthesis, and characterisation of glyoxylamide-based short peptides as self-assembled gels"],"prefix":"10.1039","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-1506","authenticated-orcid":false,"given":"Vina R.","family":"Aldilla","sequence":"first","affiliation":[{"name":"School of Chemistry"},{"name":"UNSW Australia"},{"name":"Sydney"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8504-0375","authenticated-orcid":false,"given":"Shashidhar","family":"Nizalapur","sequence":"additional","affiliation":[{"name":"School of Chemistry"},{"name":"UNSW Australia"},{"name":"Sydney"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5445-0299","authenticated-orcid":false,"given":"Adam","family":"Martin","sequence":"additional","affiliation":[{"name":"School of Chemistry"},{"name":"UNSW Australia"},{"name":"Sydney"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0549-0363","authenticated-orcid":false,"given":"Chris E.","family":"Marjo","sequence":"additional","affiliation":[{"name":"Mark Wainwright Analytical Centre"},{"name":"UNSW Australia"},{"name":"Sydney NSW 2052"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2326-7002","authenticated-orcid":false,"given":"Anne","family":"Rich","sequence":"additional","affiliation":[{"name":"Mark Wainwright Analytical Centre"},{"name":"UNSW Australia"},{"name":"Sydney NSW 2052"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1883-7549","authenticated-orcid":false,"given":"Eugene","family":"Yee","sequence":"additional","affiliation":[{"name":"School of Chemistry"},{"name":"UNSW Australia"},{"name":"Sydney"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0649-3144","authenticated-orcid":false,"given":"Panthipa","family":"Suwannakot","sequence":"additional","affiliation":[{"name":"School of Chemistry"},{"name":"UNSW Australia"},{"name":"Sydney"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9300-4737","authenticated-orcid":false,"given":"David StC.","family":"Black","sequence":"additional","affiliation":[{"name":"School of Chemistry"},{"name":"UNSW Australia"},{"name":"Sydney"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1200-8814","authenticated-orcid":false,"given":"Pall","family":"Thordarson","sequence":"additional","affiliation":[{"name":"School of Chemistry"},{"name":"UNSW Australia"},{"name":"Sydney"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0951-9621","authenticated-orcid":false,"given":"Naresh","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Chemistry"},{"name":"UNSW Australia"},{"name":"Sydney"},{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2017]]},"reference":[{"key":"C7NJ02248D-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/asia.201000592","volume":"6","author":"Truong","year":"2011","journal-title":"Chem. \u2013 Asian J."},{"key":"C7NJ02248D-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6881","DOI":"10.1039\/C4CS00164H","volume":"43","author":"Adler-Abramovich","year":"2014","journal-title":"Chem. 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(2014). \u201cField monitoring of seasonal ground movements in expansive soils in Melbourne.\u201d Unsaturated Soils: Research & Applications, CRC Press, 1359\u20131365."},{"key":"e_1_4_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1061\/(ASCE)1090-0241(2004)130:6(572)"},{"key":"e_1_4_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1061\/(ASCE)0733-9410(1990)116:7(1073)"},{"key":"e_1_4_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/joc.1627"},{"key":"e_1_4_2_1_23_1","volume-title":"NHBC Standards 2020","author":"NHBC (National House-Building Council)","year":"2020","unstructured":"NHBC (National House-Building Council). (2020). NHBC Standards 2020. National House-Building Council (NHBC), London, UK."},{"issue":"1","key":"e_1_4_2_1_24_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1260\/095830506776318804","article-title":"Observed climate change in Australia over the past century.","volume":"17","author":"Nicholls N.","year":"2006","unstructured":"Nicholls, N., and Collins, D. (2006). \u201cObserved climate change in Australia over the past century.\u201d Energy & Environment, 17(1), 1\u201312.","journal-title":"Energy & Environment"},{"key":"e_1_4_2_1_25_1","doi-asserted-by":"crossref","unstructured":"Olaiz A. H. Singhar S. H. Vann J. D. and Houston S. L. (2018). \u201cComparison and applications of the Thornthwaite moisture index using GIS.\u201d PanAm Unsaturated Soils 2017 280\u2013289.","DOI":"10.1061\/9780784481691.028"},{"issue":"4","key":"e_1_4_2_1_26_1","first-page":"1","article-title":"Damage to foundations from expansive soils.","volume":"3","author":"Rogers J. D.","year":"1993","unstructured":"Rogers, J. D., Olshansky, R., and Rogers, R. B. (1993). \u201cDamage to foundations from expansive soils.\u201d Claims People, 3(4), 1\u20134.","journal-title":"Claims People"},{"key":"e_1_4_2_1_27_1","volume-title":"The impact of climate as expressed by Thornthwaite moisture index on residential footing design on expansive soil in Australia","author":"Sun X.","year":"2015","unstructured":"Sun, X. (2015). The impact of climate as expressed by Thornthwaite moisture index on residential footing design on expansive soil in Australia. RMIT University."},{"issue":"10","key":"e_1_4_2_1_28_1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1177\/03611981211013026","article-title":"Assessing climate change impact on asphalt binder grade selection and its implications.","volume":"2675","author":"Swarna S. T.","year":"2021","unstructured":"Swarna, S. T., Hossain, K., Pandya, H., and Mehta, Y. A. (2021). \u201cAssessing climate change impact on asphalt binder grade selection and its implications.\u201d Transportation Research Record, 2675(10), 786\u2013799.","journal-title":"Transportation Research Record"},{"key":"e_1_4_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.2307\/210739"},{"key":"e_1_4_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1680\/envgeo.13.00055"},{"issue":"3","key":"e_1_4_2_1_31_1","first-page":"37","article-title":"A note on the depth of design suction change for clays in South Western Australia and South Eastern Queensland.","volume":"33","author":"Walsh P.","year":"1998","unstructured":"Walsh, P., Fityus, S., and Kleeman, P. (1998). \u201cA note on the depth of design suction change for clays in South Western Australia and South Eastern Queensland.\u201d Australian Geomechanics, 33(3), 37\u201340.","journal-title":"Australian Geomechanics"},{"key":"e_1_4_2_1_32_1","volume-title":"Models Incorporated into the Current Enhanced Integrated Climatic Model for Version 1.0 of the ME-PDG","author":"Witczak M. W.","year":"2006","unstructured":"Witczak, M. W., Zapata, C. E., and Houston, W. N. (2006). Models Incorporated into the Current Enhanced Integrated Climatic Model for Version 1.0 of the ME-PDG. Arizona State University: Tempe, AZ, USA."}],"event":{"name":"Geo-Congress 2023","location":"Los Angeles, California"},"container-title":["Geo-Congress 2023"],"link":[{"URL":"https:\/\/ascelibrary.org\/doi\/pdf\/10.1061\/9780784484661.068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:11:42Z","timestamp":1782882702000},"score":7.599133,"resource":{"primary":{"URL":"https:\/\/ascelibrary.org\/doi\/10.1061\/9780784484661.068"}},"issued":{"date-parts":[[2023,3,23]]},"references-count":31,"alternative-id":["10.1061\/9780784484661.068","10.1061\/9780784484661"],"URL":"https:\/\/doi.org\/10.1061\/9780784484661.068","published":{"date-parts":[[2023,3,23]]}},{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T04:10:48Z","timestamp":1750997448464,"version":"3.41.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl_1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2024,11,12]]},"abstract":"\n Introduction:<\/jats:bold>\n Concerns have been raised regarding the potential adverse effect of beta-blockers particularly in limiting chronotropic response in Heart failure with preserved ejection fraction (HFpEF) patients. While beta-blockers are commonly used in Atrial fibrillation (AF) management, their effect in patients with both AF and HFpEF remains uncertain.\n <\/jats:p>\n \n Methods:<\/jats:bold>\n In patients undergoing AF ablation, invasive left atrial (LA) hemodynamic measurements were obtained at rest and following 500mL fluid challenge. Patients with HFpEF (baseline mean LA pressure >15 mmHg) and preclinical HFpEF (baseline mean LA pressure <15 mmHg, increasing to >15 mmHg post-fluid challenge) were included for analysis. Two subgroups were identified based on the use of rate-limiting medications (RLM) at the time of recruitment. The validated AF Severity Scale (AFSS) and Minnesota Living with Heart Failure questionnaire (MLHFQ) were utilised to assess AF and HFpEF symptoms respectively. Baseline Pro-BNP level and cardiopulmonary exercise test were also performed.\n <\/jats:p>\n \n Results:<\/jats:bold>\n Of the 88 patients (mean age 65.1 \u00b1 10.8 years, 64% males) included for analysis, 63.6% had clinical HFpEF and 36.4% had preclinical HFpEF. Patients on RLM (79.5%) and not on RLM (20.5%) had similar baseline characteristics including age (\n p<\/jats:italic>\n =0.53) sex (\n p<\/jats:italic>\n =0.24) type of AF (\n p<\/jats:italic>\n =0.43) and pacemaker implantation (\n p<\/jats:italic>\n =1.0). Treatment with beta-blockers did not significantly affect quality of life as measured by the AFSS (\n p<\/jats:italic>\n =0.77) reported global wellbeing (\n p<\/jats:italic>\n =0.51) or exercise capacity as assessed by maximum heart rate at peak exercise (\n p<\/jats:italic>\n =0.75) and peak oxygen consumption (VO2ml\/kg.min) (\n p<\/jats:italic>\n =0.65). Additionally, there were no differences between groups in self-reported heart failure (HF) symptoms as measured by the MLHFQ (\n p<\/jats:italic>\n =0.69) or in mean Pro-BNP levels (\n p<\/jats:italic>\n =0.63). Results were consistent when groups matched for age and sex.\n <\/jats:p>\n \n Conclusions:<\/jats:bold>\n While there is some apprehension regarding the use of RLM in patients with HFpEF, in this observational study, there was no difference in exercise capacity, quality of life, HF symptoms or biomarkers between those using RLM and those not.\n <\/jats:p>","DOI":"10.1161\/circ.150.suppl_1.4142619","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T09:02:39Z","timestamp":1731574959000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 4142619: Implications of Rate Limiting Medications in Patients with Atrial Fibrillation and Heart Failure with Preserved Ejection Fraction"],"prefix":"10.1161","volume":"150","author":[{"given":"Mohamed","family":"Abbas","sequence":"first","affiliation":[{"name":"University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Ariyaratnam","sequence":"additional","affiliation":[{"name":"University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenelle","family":"Dziano","sequence":"additional","affiliation":[{"name":"University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackson","family":"Howie","sequence":"additional","affiliation":[{"name":"University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohanaraj","family":"Jayakumar","sequence":"additional","affiliation":[{"name":"University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun","family":"Evans","sequence":"additional","affiliation":[{"name":"University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Elliott","sequence":"additional","affiliation":[{"name":"University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashanthan","family":"Sanders","sequence":"additional","affiliation":[{"name":"University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1161\/circ.150.suppl_1.4142619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T14:01:22Z","timestamp":1750946482000},"score":7.5991096,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/circ.150.suppl_1.4142619"}},"issued":{"date-parts":[[2024,11,12]]},"references-count":0,"journal-issue":{"issue":"Suppl_1","published-print":{"date-parts":[[2024,11,12]]}},"alternative-id":["10.1161\/circ.150.suppl_1.4142619"],"URL":"https:\/\/doi.org\/10.1161\/circ.150.suppl_1.4142619","ISSN":["0009-7322","1524-4539"],"issn-type":[{"type":"print","value":"0009-7322"},{"type":"electronic","value":"1524-4539"}],"published":{"date-parts":[[2024,11,12]]},"assertion":[{"value":"2024-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:56:27Z","timestamp":1783050987500,"version":"3.54.6"},"reference-count":73,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2023,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Prehabilitation seeks to optimize patient health before surgery to improve outcomes. Randomized controlled trials (RCTs) have been conducted on prehabilitation, however an updated synthesis of this evidence is required across General Surgery to inform potential Supplementary discipline\u2010level protocols. Accordingly, this systematic review of RCTs aimed to evaluate the use of prehabilitation interventions across the discipline of General Surgery.<\/jats:p><\/jats:sec>Methods<\/jats:title>This study was registered with PROSPERO (CRD42023403289), and adhered to PRISMA 2020 and SWiM guidelines. PubMed\/MEDLINE and Ovid Embase were searched to 4 March 2023 for RCTs evaluating prehabilitation interventions within the discipline of General Surgery. After data extraction, risk of bias was assessed using the Cochrane RoB 2 tool. Quantitative and qualitative data were synthesized and analysed. However, meta\u2010analysis was precluded due to heterogeneity across included studies.<\/jats:p><\/jats:sec>Results<\/jats:title>From 929 records, 36 RCTs of mostly low risk of bias were included. 17 (47.2%) were from Europe, and 14 (38.9%) North America. 30 (83.3%) investigated cancer populations. 31 (86.1%) investigated physical interventions, finding no significant difference in 16 (51.6%) and significant improvement in 14 (45.2%). Nine (25%) investigated psychological interventions: six (66.7%) found significant improvement, three (33.3%) found no significant difference. Five (13.9%) investigated nutritional interventions, finding no significant difference in three (60%), and significant improvement in two (40%).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Prehabilitation interventions showed mixed levels of effectiveness, and there is insufficient RCT evidence to suggest system\u2010level delivery across General Surgery within standardized protocols. However, given potential benefits and non\u2010inferiority to standard care, they should be considered on a case\u2010by\u2010case basis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18684","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T11:54:55Z","timestamp":1694087695000},"page":"2411-2425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prehabilitation for general surgery: a systematic review of randomized controlled trials"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3880-3840","authenticated-orcid":false,"given":"Joshua G.","family":"Kovoor","sequence":"first","affiliation":[{"name":"University of Sydney Sydney New South Wales Australia"},{"name":"Queen Elizabeth Hospital Adelaide South Australia Australia"},{"name":"Health and Information Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silas D.","family":"Nann","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"Gold Coast University Hospital Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwarkesh D.","family":"Barot","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"Gold Coast University Hospital Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devanshu","family":"Garg","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0577-9105","authenticated-orcid":false,"given":"Lewis","family":"Hains","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-3489","authenticated-orcid":false,"given":"Brandon","family":"Stretton","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Adelaide South Australia Australia"},{"name":"Health and Information Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8075-7852","authenticated-orcid":false,"given":"Christopher D.","family":"Ovenden","sequence":"additional","affiliation":[{"name":"Health and Information Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Bacchi","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Adelaide South Australia Australia"},{"name":"Health and Information Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-5294","authenticated-orcid":false,"given":"Erick","family":"Chan","sequence":"additional","affiliation":[{"name":"Gold Coast University Hospital Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-0378","authenticated-orcid":false,"given":"Aashray K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"University of Sydney Sydney New South Wales Australia"},{"name":"Health and Information Adelaide South Australia Australia"},{"name":"Gold Coast University Hospital Gold Coast Queensland Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6690-342X","authenticated-orcid":false,"given":"Thomas J.","family":"Hugh","sequence":"additional","affiliation":[{"name":"University of Sydney Sydney New South Wales Australia"},{"name":"Royal North Shore Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j3702"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.245"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviscsurg.2016.01.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60160-X"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60878-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2021.11.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-019-04950-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-022-04088-w"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13429"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.01.111"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215514545350"},{"key":"e_1_2_9_13_1","article-title":"Prehabilitation versus no prehabilitation to improve functional capacity, reduce postoperative complications and improve quality of life in colorectal cancer surgery","volume":"2022","author":"Molenaar CJ","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.05.014"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-050806"},{"key":"e_1_2_9_16_1","article-title":"Psychological preparation and postoperative outcomes for adults undergoing surgery under general anaesthesia","volume":"2016","author":"Powell R","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physio.2013.08.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001030"},{"key":"e_1_2_9_19_1","unstructured":"Royal Australasian College of Surgeons.Surgical Specialties. 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K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Gold Coast University Hospital Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua G.","family":"Kovoor","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher D.","family":"Ovenden","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh\u2010Son","family":"To","sequence":"additional","affiliation":[{"name":"Flinders Health and Medical Research Institute Flinders University Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Jiang","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1645-2258","authenticated-orcid":false,"given":"Rudy","family":"Goh","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Gluck","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Lyell McEwin Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3431-9672","authenticated-orcid":false,"given":"Toby","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"e_1_2_1_2_2_1","first-page":"e257","article-title":"How, when and where to discuss do not resuscitate: a prospective study to compare the perceptions and preferences of patients, caregivers, and health care providers in a multidisciplinary lung cancer clinic","volume":"7","author":"Ahmed N","year":"2015","journal-title":"Cureus"},{"key":"e_1_2_1_2_3_1","unstructured":"Australian Bureau of Statistics.Census of Population and Housing: Socio\u2010Economic Indexes for Areas (SEIFA) Australia 2016. Commonwealth Goverment of Australia; 2016."},{"key":"e_1_2_1_2_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2015.0388"},{"key":"e_1_2_1_2_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014200"},{"key":"e_1_2_1_2_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002814"},{"key":"e_1_2_1_2_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000197683.89002.62"},{"key":"e_1_2_1_2_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181926430"}],"container-title":["Internal Medicine Journal"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.15923","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.15923","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.15923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T02:38:41Z","timestamp":1692671921000},"score":7.5985827,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.15923"}},"issued":{"date-parts":[[2022,10]]},"references-count":7,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/imj.15923"],"URL":"https:\/\/doi.org\/10.1111\/imj.15923","archive":["Portico"],"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"2022-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T09:40:45Z","timestamp":1653385245427},"reference-count":26,"publisher":"Yong Loo Lin School of Medicine","issue":"1","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/medicine.nus.edu.sg\/taps\/for-authors\/policies\/"}],"content-domain":{"domain":["medicine.nus.edu.sg"],"crossmark-restriction":false},"short-container-title":["TAPS"],"abstract":"Introduction: In 2017, the School of Medicine of the University of Notre Dame Australia implemented a data-informed mentoring program as part of a more substantial shift towards programmatic assessment. Data-informed mentoring, in an educational context, can be challenging with boundaries between mentor, coach and assessor roles sometimes blurred. Mentors may be required to concurrently develop trust relationships, guide learning and development, and assess student performance. The place of data-informed mentoring within an overall assessment design can also be ambiguous. This paper is a preliminary evaluation study of the implementation of data informed mentoring at a medical school, focusing specifically on how students and staff reacted and responded to the initiative.\nMethods: Action research framed and guided the conduct of the research. Mixed methods, involving qualitative and quantitative tools, were used with data collected from students through questionnaires and mentors through focus groups.\nResults: Both students and mentors appreciated data-informed mentoring and indications are that it is an effective augmentation to the School\u2019s educational program, serving as a useful step towards the implementation of programmatic assessment.\nConclusion: Although data-informed mentoring is valued by students and mentors, more work is required to: better integrate it with assessment policies and practices; stimulate students\u2019 intrinsic motivation; improve task design and feedback processes; develop consistent learner-centred approaches to mentoring; and support data-informed mentoring with appropriate information and communications technologies. The initiative is described using an ecological model that may be useful to organisations considering data-informed mentoring.<\/jats:p>","DOI":"10.29060\/taps.2021-6-1\/oa2239","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T03:45:42Z","timestamp":1605671142000},"page":"60-69","update-policy":"http:\/\/dx.doi.org\/10.29060\/taps.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A preliminary evaluation of data-informed mentoring at an Australian medical school"],"prefix":"10.29060","volume":"6","author":[{"given":"Frank","family":"Bate","sequence":"first","affiliation":[{"name":"University of Notre Dame Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue","family":"Fyfe","sequence":"additional","affiliation":[{"name":"Curtin University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylan","family":"Griffiths","sequence":"additional","affiliation":[{"name":"University of Notre Dame Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kylie","family":"Russell","sequence":"additional","affiliation":[{"name":"University of Notre Dame Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Skinner","sequence":"additional","affiliation":[{"name":"University of Notre Dame Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Tor","sequence":"additional","affiliation":[{"name":"University of Notre Dame Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11598","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Bate, F., Fyfe, S., Griffiths, D., Russell, K., Skinner, C., & Tor, E. (2020). Does an incremental approach to implementing programmatic assessment work: Reflections on the change process. MedEdPublish, 9(1), 55.","DOI":"10.15694\/mep.2020.000055.1"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.15694\/mep.2020.000055.1"},{"key":"ref2","unstructured":"Bate, F., Macnish, J., & Skinner, C. (2016). The cart before the horse? Exploring the potential of ePortfolios in a Western Australian medical school. International Journal of ePortfolio, 6 (2), 85-94."},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Bhat, C., Burm, S., Mohan, T., Chahine, S., & Goldszmidt, M. (2018). What trainees grapple with: A study of threshold concepts on the medicine ward. Medical Education, 52(6), 620\u2013631. https:\/\/doi.org\/10.1111\/medu.13526","DOI":"10.1111\/medu.13526"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Braun, V., & Clarke, V. (2006). Using thematic analysis in psychology. Qualitative Research in Psychology, 3, 77-101.","DOI":"10.1191\/1478088706qp063oa"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Candy, P. (2006). Promoting lifelong learning: Academic developers and the university as a learning organization. International Journal for Academic Development, 1(1), 7-18. https:\/\/doi.org\/10.1080\/1360144960010102","DOI":"10.1080\/1360144960010102"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Frei, E., Stamm, M., & Buddeberg-Fischer, B. (2010). Mentoring programs for medical students: A review of PubMed literature 2000-2008, BMC Medical Education, 10(32), 1-14. https:\/\/doi.org\/10.1186\/1472-6920-10-32","DOI":"10.1186\/1472-6920-10-32"},{"key":"ref8","unstructured":"Gillis, A., & Jackson, W. (2002). Research for Nurses: Methods and Interpretation. Philadelphia, PA: F.A. Davis Co."},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Heeneman, S., & de Grave, W. (2017). Tensions in mentoring medical students toward self-directed and reflective learning in a longitudinal portfolio-based mentoring system \u2013 An activity theory analysis. Medical Teacher, 39(4), 368-376.","DOI":"10.1080\/0142159x.2017.1286308"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/0142159X.2017.1286308"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Heeneman, S., & de Grave, W. (2019). Development and initial validation of a dual-purpose questionnaire capturing mentors\u2019 and mentees\u2019 perceptions and expectations of the mentoring process. BMC Medical Education, 19(133), 1-13.","DOI":"10.1186\/s12909-019-1574-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s12909-019-1574-2"},{"key":"ref13","unstructured":"Kemmis, S., & McTaggart, R. (2000). Participatory action research. In N. K. Denzin & Y. S. Lincoln (Eds.) Handbook of Qualitative Research (2nd Ed.; pp 567-606). New York: Sage Publications."},{"key":"ref14","unstructured":"Kirkpatrick, D., & Kirkpatrick, J. (2006). Evaluating Training Programs: The Four Levels (3rd ed.). Oakland, CA: Berrett-Koehler Publishers, Inc."},{"key":"ref15","unstructured":"Kuykendall, B., Janvier, M., Kempton, I., & Brown, D. (2012). Interactive whiteboard technology: Promise and reality. In T. Bastiaens & G. Marks (Eds.), Proceedings of E-Learn 2012 - World Conference on E-Learning in Corporate, Government, Healthcare, and Higher Education 1 (pp. 685-690). Retrieved from Association for the Advancement of Computing in Education (AACE), https:\/\/www.learntechlib.org\/p\/41669"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Meeuwissen, N., Stalmeijer, R., & Govaerts, M. (2019). Multiple-role mentoring: Mentors conceptualisations, enactments and role conflicts. Medical Education, 53, 605-615.","DOI":"10.1111\/medu.13811"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/medu.13811"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Richter, D., Kunter, M., L\u00fcdtke, O., Klusmann, U., Anders, Y., & Baumert, J. (2013). How different mentoring approaches affect beginning teachers\u2019 development in the first years of practice. Teaching and Teacher Education, 36, 166-177.","DOI":"10.1016\/j.tate.2013.07.012"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tate.2013.07.012"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Sambunjak, D. (2015). Understanding the wider environmental influences on mentoring: Towards an ecological model of mentoring in academic medicine. Acta Medica Academia, 44(1), 47-57. https:\/\/doi.org\/10.5644\/ama2006-124.126","DOI":"10.5644\/ama2006-124.126"},{"key":"ref21","unstructured":"Standing Committee on Postgraduate Medical and Dental Education. (1998). Supporting Doctors and Dentists at Work: An Enquiry into Mentoring. London: SCOPME."},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Stenfors-Hayes, T., Hult, H., & Owe Dahlgren, L. (2011). What does it mean to be a mentor in medical education? Medical Teacher, 33(8), 423-428.","DOI":"10.3109\/0142159x.2011.586746"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3109\/0142159X.2011.586746"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Waljee, J. F., Copra, V., & Saint, S. (2018). Mentoring Millennials. JAMA, 319(15), 1547-1548.","DOI":"10.1001\/jama.2018.3804"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.3804"}],"container-title":["The Asia Pacific Scholar"],"language":"en","deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T09:07:22Z","timestamp":1653383242000},"score":7.598262,"resource":{"primary":{"URL":"https:\/\/medicine.nus.edu.sg\/taps\/a-preliminary-evaluation-of-data-informed-mentoring-at-an-australian-medical-school\/"}},"issued":{"date-parts":[[2021,1,5]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,5]]}},"URL":"https:\/\/doi.org\/10.29060\/taps.2021-6-1\/oa2239","ISSN":["2424-9270","2424-9335"],"issn-type":[{"value":"2424-9270","type":"electronic"},{"value":"2424-9335","type":"print"}],"published":{"date-parts":[[2021,1,5]]}},{"indexed":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T07:40:10Z","timestamp":1745307610296,"version":"3.40.4"},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"8_Supplement_1","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,4,21]]},"abstract":"\n Background and Aims:<\/jats:title>\n Genetic heterogeneity in ovarian cancer drives frequent aberrant expression of cell surface proteins including G-protein coupled receptors (GPCRs), which harbour untapped potential for active targeting with nanomedicines. Our goal was to systematically identify GPCRs with significant overexpression in ovarian cancer biopsies and assessing their suitability to develop personalized GPCR-targeted nanomedicines for precise drug delivery.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We ran a systematic analysis of public RNA-seq gene expression data, to reveal GPCRs with frequent overexpression in ovarian cancer tissues. To validate the relevance of initially identified receptors as targeting candidates, we confirmed their expression in six ovarian cancer cell lines and a selection of patient-derived samples (ascites derived tumour samples and solid tumours), using techniques such as RT-qPCR, flow cytometry, fluorescence imaging and immunofluorescence. This comprehensive analysis provided valuable insights into the prevalence and distribution of candidate receptors across different ovarian cancer probes. Furthermore, we utilized representative ovarian cancer cell lines as in vitro models to assess receptor-mediated cellular uptake and internalization processes, to further evaluate potential targets for nanoparticle delivery systems.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Analysis of public RNA-Seq datasets revealed 13 overexpressed GPCRs in cancer tissues compared to healthy tissues. Among these, we focused specifically on the coagulation factor II thrombin receptor (F2R) to highlight its intriguing potential as a therapeutic target. The variable expression of F2R was confirmed in both ovarian cancer cell lines and patient-derived samples. Furthermore, peptide binding to the receptor was successfully demonstrated using flow cytometry and fluorescent imaging, suggesting a promising approach for targeted drug delivery.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n and Significance: Our findings underscore the importance of personalized targeting approaches in ovarian cancer therapy and highlight the potential of F2R as a promising therapeutic target. By integrating advanced molecular techniques with nanomedicine strategies, we strive to pave the way for more effective and tailored treatments for ovarian cancer patients.<\/jats:p>\n <\/jats:sec>\n \n Citation Format:<\/jats:title>\n Riya Khetan, Preethi Eldi, Noor Lokman, Carmela Ricciardelli, Martin Oehler, Anton Blencowe, Katherine Pillman, Sanjay Garg, Hugo Albrecht. Leveraging GPCR overexpression for personalized nanomedicine: A novel approach in ovarian cancer therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 5995.<\/jats:p>\n <\/jats:sec>","DOI":"10.1158\/1538-7445.am2025-5995","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T15:20:25Z","timestamp":1745248825000},"page":"5995-5995","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 5995: Leveraging GPCR overexpression for personalized nanomedicine: A novel approach in ovarian cancer therapy"],"prefix":"10.1158","volume":"85","author":[{"given":"Riya","family":"Khetan","sequence":"first","affiliation":[{"name":"1University of South Australia, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preethi","family":"Eldi","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor","family":"Lokman","sequence":"additional","affiliation":[{"name":"2University of Adelaide, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela","family":"Ricciardelli","sequence":"additional","affiliation":[{"name":"2University of Adelaide, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Oehler","sequence":"additional","affiliation":[{"name":"3Royal Adelaide Hospital, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Blencowe","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Pillman","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Garg","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Albrecht","sequence":"additional","affiliation":[{"name":"1University of South Australia, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/85\/8_Supplement_1\/5995\/758043\/Abstract-5995-Leveraging-GPCR-overexpression-for","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/85\/8_Supplement_1\/5995\/758043\/Abstract-5995-Leveraging-GPCR-overexpression-for","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T07:25:30Z","timestamp":1745306730000},"score":7.5982494,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/85\/8_Supplement_1\/5995\/758043\/Abstract-5995-Leveraging-GPCR-overexpression-for"}},"issued":{"date-parts":[[2025,4,21]]},"references-count":0,"journal-issue":{"issue":"8_Supplement_1","published-print":{"date-parts":[[2025,4,21]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2025-5995","ISSN":["0008-5472","1538-7445"],"issn-type":[{"type":"print","value":"0008-5472"},{"type":"electronic","value":"1538-7445"}],"published":{"date-parts":[[2025,4,21]]}},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:42:09Z","timestamp":1651210929003},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.juro.2017.02.2529","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T18:37:51Z","timestamp":1491244671000},"source":"Crossref","is-referenced-by-count":0,"title":["MP81-03 ERECTILE DYSFUNCTION IS INDEPENDENTLY ASSOCIATED WITH APNEA HYPOPNEA INDEX & OXYGEN DESATURATION INDEX IN ELDERLY, BUT NOT YOUNGER, COMMUNITY-DWELLING MEN"],"prefix":"10.1097","volume":"197","author":[{"given":"Sean","family":"Martin","sequence":"first","affiliation":[{"name":"Adelaide, 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Wittert","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534717339952?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534717339952?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2017.02.2529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:25:16Z","timestamp":1651209916000},"score":7.5981383,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2017.02.2529"}},"issued":{"date-parts":[[2017,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1016\/j.juro.2017.02.2529"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2017.02.2529","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2017,4]]}},{"indexed":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T18:10:02Z","timestamp":1750961402692,"version":"3.41.0"},"reference-count":38,"publisher":"SAGE 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However, the concept of remix is common across this wide range of media, and offers practitioners \u2018endless hybridizations in language, genre, content, technique and the like\u2019 (Knobel & Lankshear, 2008, p. 22). The conceptual commonality of remix indicates that the study conclusions will have useful implications across a range of media production disciplines. This study aims to consider new methods for testing creativity in media production learning activities and to provide better assessments for learning design. This study focused upon a learner cohort of music technology students that were undertaking a work-integrated learning programme with a record label. To make the students more work-ready and inspire greater creativity, they remixed tracks recorded by professional music artists as part of a unit assessment. Subsequent self-report surveys ( N = 29) found that the process of creating a \u2018remix\u2019 enhanced their creativity and provided suggested improvements to the design of the learning experience. Importantly, we found no relationship between the survey responses and objective assessments, indicating that the self-reported improvements in creativity were not simply a measure of how well the students performed the formally assessed tasks. Although more research is needed to establish effective measures of creativity, these findings demonstrate that self-report survey tools can be a powerful tool for measuring creativity and supporting improved iterative learning design.<\/jats:p>","DOI":"10.1177\/1326365x17728827","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T15:23:31Z","timestamp":1508772211000},"page":"298-310","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Remixing Creativity in Learning and Learning of Creativity: A Case Study of Audio Remix Practice with Undergraduate Students"],"prefix":"10.1177","volume":"27","author":[{"given":"Simon","family":"Order","sequence":"first","affiliation":[{"name":"Murdoch University, Western Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Murray","sequence":"additional","affiliation":[{"name":"Murdoch University, Western Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Prince","sequence":"additional","affiliation":[{"name":"Murdoch University, Western Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Hobson","sequence":"additional","affiliation":[{"name":"Murdoch University, Western Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara de","family":"Freitas","sequence":"additional","affiliation":[{"name":"Murdoch University, Western Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,10,20]]},"reference":[{"volume-title":"Creativity in context","year":"1996","author":"Amabile T.","key":"bibr1-1326365X17728827"},{"key":"bibr2-1326365X17728827","doi-asserted-by":"publisher","DOI":"10.1207\/s15326934crj1204_6"},{"key":"bibr3-1326365X17728827","doi-asserted-by":"publisher","DOI":"10.1016\/S0748-5751(98)00012-8"},{"key":"bibr4-1326365X17728827","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-0096-7_2"},{"volume-title":"Media education: Literacy, learning and contemporary culture","year":"2003","author":"Buckingham D.","key":"bibr5-1326365X17728827"},{"issue":"4","key":"bibr6-1326365X17728827","volume":"52","author":"Burwell C.","year":"2014","journal-title":"Education Canada"},{"key":"bibr7-1326365X17728827","doi-asserted-by":"publisher","DOI":"10.1111\/1467-8527.t01-1-00229"},{"key":"bibr8-1326365X17728827","doi-asserted-by":"publisher","DOI":"10.1080\/02783190009554069"},{"key":"bibr9-1326365X17728827","doi-asserted-by":"publisher","DOI":"10.1080\/14613800600581659"},{"volume-title":"Society, culture, and person: A systems view of creativity","year":"2014","author":"Csikszentmihalyi M.","key":"bibr10-1326365X17728827"},{"key":"bibr11-1326365X17728827","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-9085-7_10"},{"key":"bibr12-1326365X17728827","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.125.6.627"},{"key":"bibr13-1326365X17728827","doi-asserted-by":"publisher","DOI":"10.1207\/s15327957pspr0204_5"},{"key":"bibr14-1326365X17728827","volume-title":"Human motivation","author":"Franken R.","year":"1994","edition":"3"},{"key":"bibr15-1326365X17728827","doi-asserted-by":"publisher","DOI":"10.1080\/10400419409534524"},{"key":"bibr16-1326365X17728827","doi-asserted-by":"publisher","DOI":"10.1080\/03057640600866015"},{"volume-title":"The creativity checklist","year":"1979","author":"Johnson D. 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The first 3 years of interventions aimed to make effective use of preoperative clinics, manage perioperative anemia, improve perioperative hemostasis, reduce blood sample volumes, and implement restrictive transfusion triggers and a single\u2010unit transfusion policy.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Between 2008 and 2011, admissions to\n F<\/jats:styled-content>\n remantle\n H<\/jats:styled-content>\n ospital and\n H<\/jats:styled-content>\n ealth\n S<\/jats:styled-content>\n ervices increased by 22%. Using 2008 as a reference year, the mean number of red blood cell (RBC) units per admission declined 26% by 2011. Use of fresh\u2010frozen plasma and platelets showed 38 and 16% declines, respectively. Cryoprecipitate increased 7% over the 4\u2010year period. For elective admissions between 2008 and 2011, the leading decline in RBC transfusion rate was seen in cardiothoracic surgery (27.5% to 12.8%). The proportion of single RBC unit use increased from 13% to 28% (p\u2009<\u20090.001), and the proportion of double units decreased from 48% to 37% (p\u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This is the first tertiary hospital in\n A<\/jats:styled-content>\n ustralia to establish a multidisciplinary multimodal\n PBMP<\/jats:styled-content>\n . Interventions across disciplines resulted in decreased use of RBC units especially in orthopedic and cardiothoracic surgery. Continuing education and feedback to specialties will maintain the program, improve patient outcomes, and decrease the transfusion rate.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/trf.12362","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T22:14:56Z","timestamp":1376000096000},"page":"1133-1145","source":"Crossref","is-referenced-by-count":79,"title":["A pragmatic approach to embedding patient blood management in a tertiary hospital"],"prefix":"10.1111","volume":"54","author":[{"given":"Michael F.","family":"Leahy","sequence":"first","affiliation":[{"name":"Hematology Department Fremantle Hospital Fremantle Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Health Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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There are limited studies internationally showing low screening rates for osteoporosis in IBD patients. There are no studies of osteoporosis screening in an Australian IBD cohort.<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n To determine the screening rate of osteoporosis in patients with IBD in an Australian tertiary IBD clinic using an extensive risk factor assessment.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective clinical audit; 252 individual patient records were reviewed from IBD clinic lists. A hybridized screening criterion was created from the European Crohn's and Colitis Organisation, British Society of Gastroenterology and Royal Australian College of General Practitioners guidelines. If patients were not up to date with screening, they were assessed as to whether they had met screening criteria during 2020\/2021 and if they were recommended for a dual energy x\u2010ray absorptiometry (DEXA) scan. If patients met criteria, DEXA scan results were collated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n 173 patients with IBD were included, 23 patients were up to date with screening and 150 required risk assessment. 101 patients met screening criteria, 12 had a DEXA completed during the study period. In the 35 DEXAs completed before or during the study, 37% showed osteoporosis, 40% showed osteopenia and 23% were normal.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n A minority of patients who were identified as at risk of osteoporosis had a DEXA scan completed. Rates of reduced bone mineral density were high in the DEXA scans completed. Future directions should focus on validating expanded Medicare criteria to ensure at\u2010risk patients may be screened.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jgh3.70313","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T14:29:53Z","timestamp":1765204193000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Screening for Osteoporosis in Inflammatory Bowel Disease Patients at a Tertiary\n IBD<\/scp>\n Clinic"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6679-2916","authenticated-orcid":false,"given":"Tamerik","family":"Urbisinov","sequence":"first","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lightowler","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7275-7051","authenticated-orcid":false,"given":"Fiona","family":"Yeaman","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"WHO \u201cWHO Scientific Group on the Assessment of Osteoporosis at Primary Health Care Level \u201d(Brussels Belgium World Health Organisation: 2004)."},{"issue":"12","key":"e_1_2_12_3_1","article-title":"Osteoporosis Complications in Crohn's Disease Patients: Factors, Pathogenesis, and Treatment Outlines","volume":"13","author":"Baban Y. 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This study utilized a combination of scRNAseq, CITE-seq, a method for CODEX, 40+ protein marker tissue imaging to characterize the molecular and spatial features of cells within melanoma biopsies of patients receiving anti-PD-1 and CTLA-4 immunotherapies. Analysis was conducted on melanoma biopsies taken pre-treatment, early during treatment (7-14 days) and after disease progression. Five patients underwent all analyses; three were responding, two had primary resistance and one had acquired resistance. Tissue dissociates underwent ssRNAseq along with CITE-seq, which incorporated 153+ antibodies to extensively define tumor and immune cell phenotypes. A separate portion of the same lesion underwent formalin fixation and paraffin embedding and was then analyzed using the CODEX high-multiplex imaging system to spatially localize 40+ markers in the tumor. The CODEX imaging system and processor (Akoya Biosciences) were used to generate multiplex images. HALO AI (Indica Labs) was used to perform cell segmentation and quantify single-cell marker expression of the 40+ markers. Tumor areas were classified into vasculature (CD34+\/CD31+), melanoma (SOX10+) and stroma regions using the DenseNet deep learning classifier within HALO AI. The subsequent output contained single-cell expression, tissue classification and x and y location data, which were used to map to the CITE-seq data using the CamaraLab STvEA (Govek et al, biorix 2019) to identify CITE-seq defined populations within tissue sections. CODEX analysis of 2.2M cells revealed distinct immune phenotypes of tumor infiltrated cells compared to their peritumor counterparts, with a gradient in the upregulation of immunosuppressive and exhaustive signaling upon entering the tumor region. Changes in cellular populations during treatment were significantly related to the spatial location of the cells within the tumor. Treatment with immunotherapies causes a dynamic change in these profiles which relates to the development of tumor resistance.<\/jats:p>\n Citation Format: Camelia Quek, Ines P. Silva, Ghamdan Al-Eryani, Aaron Mayer, Nenad Bartonicek, Kate Harvey, Chi Buckley, Oliver Braubach, John F. Thompson, Jonathan R. Stretch, Robyn P M Saw, Kerwin F. Shannon, Alexander M. Menzies, Richard A. Scolyer, Georgina V. Long, Alexander Swarbrick, James S. Wilmott. CODEX highly multiplex image mapping to CITEseq datasets reveal the spatial dynamics of the TME during the development of acquired resistant in immunotherapy treated melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 2761.<\/jats:p>","DOI":"10.1158\/1538-7445.am2021-2761","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T13:51:53Z","timestamp":1625147513000},"page":"2761-2761","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Abstract 2761: CODEX highly multiplex image mapping to CITEseq datasets reveal the spatial dynamics of the TME during the development of acquired resistant in immunotherapy treated melanoma"],"prefix":"10.1158","volume":"81","author":[{"given":"Camelia","family":"Quek","sequence":"first","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines P.","family":"Silva","sequence":"additional","affiliation":[{"name":"1Melanoma Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghamdan","family":"Al-Eryani","sequence":"additional","affiliation":[{"name":"2Garvan Institute of Medical Research, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Mayer","sequence":"additional","affiliation":[{"name":"3Enable Medicine, Menlo Park, CA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nenad","family":"Bartonicek","sequence":"additional","affiliation":[{"name":"2Garvan Institute of Medical Research, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Harvey","sequence":"additional","affiliation":[{"name":"2Garvan Institute of Medical Research, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Buckley","sequence":"additional","affiliation":[{"name":"4Akoya Biosciences, Menlo Park, 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Cowan University","doi-asserted-by":"publisher","award":["26305"],"award-info":[{"award-number":["26305"]}],"id":[{"id":"10.13039\/501100001798","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Renal Care"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Residual kidney function in patients receiving haemodialysis is associated with improved survival, reduced cardiovascular risk and better quality of life. Yet, clinical guidelines on its preservation are limited, and local practices remain unclear.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To explore current practices, perceptions and challenges related to residual kidney function preservation among renal clinicians.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Descriptive cross\u2010sectional survey.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Renal physicians and nurses working in hospital\u2010based haemodialysis units across Western Australia.<\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n Role\u2010specific questionnaires were administered to renal physicians and nurses.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eighty\u2010four completed responses were received (physicians\n n<\/jats:italic>\n \u2009=\u200925; nurses\n n<\/jats:italic>\n \u2009=\u200959). Over half of physicians (56%,\n n<\/jats:italic>\n \u2009=\u200914) reported residual kidney function was present in more than half of patients at haemodialysis initiation, while most nurses (64%,\n n<\/jats:italic>\n \u2009=\u200930) indicated it was often or always present. Assessment of this function was reported by 64% of physicians (\n n<\/jats:italic>\n \u2009=\u200916) and 61% of nurses (\n n<\/jats:italic>\n \u2009=\u200936), predominantly via patient self\u2010reported urine output (physician 100%,\n n<\/jats:italic>\n \u2009=\u200916; nurses 86%,\n n<\/jats:italic>\n \u2009=\u200931). Most physicians (76%,\n n<\/jats:italic>\n \u2009=\u200919) and nearly all nurses (90%,\n n<\/jats:italic>\n \u2009=\u200953) believed preservation could improve patient outcomes. Key reported challenges included lack of consensus on optimal approaches (physicians 74%,\n n<\/jats:italic>\n \u2009=\u200917; nurses 54%,\n n<\/jats:italic>\n \u2009=\u200929), absence of clinical guidelines (nurses 61%,\n n<\/jats:italic>\n \u2009=\u200933), difficulty in accurate assessment (physicians 65%,\n n<\/jats:italic>\n \u2009=\u200915; nurses 52%,\n n<\/jats:italic>\n \u2009=\u200928), and limited patient awareness (physician 57%,\n n<\/jats:italic>\n \u2009=\u200913). Nurses identified staff education (83%\n n<\/jats:italic>\n \u2009=\u200949) and practice guidelines (81%,\n n<\/jats:italic>\n \u2009=\u200948) as key enablers to enhancing preservation efforts.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n While the clinical value of residual kidney function is widely recognised, its preservation in haemodialysis remains constrained by the lack of clinical consensus and guidelines, and limited awareness among patients and clinicians. Clear guidelines and targeted education are essential to integrate preservation practices into routine haemodialysis care.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jorc.70045","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:41:59Z","timestamp":1769161319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preserving Residual Kidney Function in Haemodialysis: Current Practices, Challenges, and Perspectives From Renal Clinicians"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9672-7103","authenticated-orcid":false,"given":"Lijun","family":"Zhong","sequence":"first","affiliation":[{"name":"Edith Cown University Joondalup Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Steinwandel","sequence":"additional","affiliation":[{"name":"Edith Cown University Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0867-2288","authenticated-orcid":false,"given":"Hugh","family":"Davies","sequence":"additional","affiliation":[{"name":"Edith Cown University Joondalup Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bayes","sequence":"additional","affiliation":[{"name":"Edith Cown University Joondalup Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagadish","family":"Jamboti","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"},{"name":"Armadale Health Service Armadale Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Chan","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1527-3"},{"key":"e_1_2_12_3_1","unstructured":"Au E. C.Davies S.Bateman et al.2024. Chapter 2: Prevalence of Kidney Failure with Replacement Therapy."},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13185529"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2019.08.003"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.80a.12122"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12558"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.07.015"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.02.008"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12576"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colegn.2022.05.007"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJNRD.S421533"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-022-02892-7"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.02.012"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000000000000221"},{"key":"e_1_2_12_16_1","unstructured":"Irish G. C.Davies E.Au et al.2024. Chapter 1: Incidence of Kidney Failure With Replacement Therapy."},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00505.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13427"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14775"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfz224"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/089686080102100108"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503805"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.09.052"},{"key":"e_1_2_12_24_1","first-page":"598","article-title":"The Influence of Dialysis Treatment Modality on the Decline of Remaining Renal Function","volume":"37","author":"Lysaght M. J.","year":"1991","journal-title":"ASAIO Transactions"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06100710"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00098.x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.05.019"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins16070298"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015101142"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2023.07.020"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04480510"},{"key":"e_1_2_12_32_1","volume-title":"Chapter 4: Haemodialysis","author":"Roberts M.","year":"2023"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.10.1814"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-012-0336-4"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.03.020"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2017.09.001"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfad280"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfz042"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143813"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016060693"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13556"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv231"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.02.002"}],"container-title":["Journal of Renal Care"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jorc.70045","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jorc.70045","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jorc.70045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:15:56Z","timestamp":1777709756000},"score":7.5974092,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jorc.70045"}},"issued":{"date-parts":[[2026,1,23]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/jorc.70045"],"URL":"https:\/\/doi.org\/10.1111\/jorc.70045","archive":["Portico"],"ISSN":["1755-6678","1755-6686"],"issn-type":[{"value":"1755-6678","type":"print"},{"value":"1755-6686","type":"electronic"}],"published":{"date-parts":[[2026,1,23]]},"assertion":[{"value":"2025-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70045"},{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:06:44Z","timestamp":1781226404176,"version":"3.54.1"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1111\/1742-6723.14295","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:33:46Z","timestamp":1692059626000},"page":"885-886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["More time per patient or more patients per unit time?"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8310-0853","authenticated-orcid":false,"given":"Sheryn","family":"Tan","sequence":"first","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-3489","authenticated-orcid":false,"given":"Brandon","family":"Stretton","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aashray","family":"Gupta","sequence":"additional","affiliation":[{"name":"The University of Adelaide Adelaide South Australia Australia"},{"name":"Gold Coast University Hospital Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Kovoor","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Bacchi","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/1742-6723.14280","article-title":"Will code one day run a code? Performance of language models on ACEM primary examinations and implications","volume":"35","author":"Smith J","year":"2023","journal-title":"Emerg. Med. Australas"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-023-02162-y"},{"key":"e_1_2_2_4_1","volume-title":"Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again","author":"Topol E","year":"2019"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnu.12055"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.1079"}],"container-title":["Emergency Medicine Australasia"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1742-6723.14295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T01:47:35Z","timestamp":1702950455000},"score":7.597269,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1742-6723.14295"}},"issued":{"date-parts":[[2023,8,14]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/1742-6723.14295"],"URL":"https:\/\/doi.org\/10.1111\/1742-6723.14295","archive":["Portico"],"ISSN":["1742-6731","1742-6723"],"issn-type":[{"value":"1742-6731","type":"print"},{"value":"1742-6723","type":"electronic"}],"published":{"date-parts":[[2023,8,14]]},"assertion":[{"value":"2023-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T13:10:42Z","timestamp":1656508242222},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"8_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2010,4,15]]},"abstract":"Abstract<\/jats:title>\n Background<\/jats:p>\n Folate plays an important role in cell function, division and differentiation. Gene polymorphisms in the folate pathway have been shown to influence folate uptake and metabolism. The aims of our study were to examine how specific gene variants in the folate pathway influence the clinical outcome of childhood neuroblastoma and to measure the correlation between specific genotypes and levels of gene expression.<\/jats:p>\n Methods<\/jats:p>\n Common single nucleotide polymorphisms (SNPs) in the folate pathway were examined in DNA from 174 children diagnosed with neuroblastoma between 1985 and 2000. Cox proportion hazard analysis was used to investigate the association between the presence or absence of specific gene polymorphisms and the risk of relapse or death in the 5 year follow up period, while adjusting for known prognostic cofactors. Relative quantification of reduced folate carrier (RFC) mRNA expression was performed in a subset of 43 neuroblastoma tissues by real-time quantitative PCR.<\/jats:p>\n Results<\/jats:p>\n No significant difference in EFS was observed between individuals with different folate genotypes (P&gt;0.05). However, in multivariate analysis children homozygous for the RFC 80A gene variant were significantly less likely to relapse or die compared to those with RFC 80G allele after adjusting for prognostic factors such as NMYC status, stage and age at diagnosis (HR=0.46; 95% CI=0.24-0.90, P=0.024). Moreover, in those patients with NMYC amplification, the cumulative 5 year EFS was 0% in those homozygous for RFC 80GG; 9% in those heterozygous for RFC 80GA; and 50% in those homozygous for RFC 80AA (Log-rank test, P=0.005). However, no apparent association was observed for any of the additional gene polymorphisms examined (P&gt;0.05) even after adjusting for NMYC status, age, or tumour stage at diagnosis. Quantitative mRNA analysis in a subset of 43 patients showed that expression of RFC was three times higher in those with RFC 80GG genotype compared to those with other genotypes, although this was not statistically significant (P=0.587).<\/jats:p>\n Conclusions<\/jats:p>\n Our results show that the RFC 80A variant allele confers superior survival in patients with NMYC amplification. These findings suggest that the RFC G80A polymorphism may play an important role in modifying folate transport in rapidly dividing neuroblastoma cells regulated by NMYC proto-oncogene.<\/jats:p>\n Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 888.<\/jats:p>","DOI":"10.1158\/1538-7445.am10-888","type":"journal-article","created":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T18:14:05Z","timestamp":1298657645000},"page":"888-888","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 888: Reduced folate carrier gene polymorphism (RFC 80G&gt;A): Associations with clinical outcome in NMYC amplified neuroblastoma patients"],"prefix":"10.1158","volume":"70","author":[{"given":"Diana T.","family":"Lau","sequence":"first","affiliation":[{"name":"1Children's Cancer Institute Australia, NSW, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayne","family":"Murray","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, NSW, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray","family":"Norris","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, NSW, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn M.","family":"Marshall","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, NSW, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Haber","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, NSW, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, NSW, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/70\/8_Supplement\/888\/566940\/Abstract-888-Reduced-folate-carrier-gene","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/70\/8_Supplement\/888\/566940\/Abstract-888-Reduced-folate-carrier-gene","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T12:57:47Z","timestamp":1656507467000},"score":7.5968175,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/70\/8_Supplement\/888\/566940\/Abstract-888-Reduced-folate-carrier-gene"}},"issued":{"date-parts":[[2010,4]]},"references-count":0,"journal-issue":{"issue":"8_Supplement","published-print":{"date-parts":[[2010,4,15]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am10-888","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published-other":{"date-parts":[[2010,4]]},"published":{"date-parts":[[2010,4]]}},{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:51:01Z","timestamp":1782100261397,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian J Rural Health"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n This project aimed to document the experiences of Aboriginal people living in the Kimberley region who have experienced diabetes\u2010related foot disease (DFD) so that service delivery can be optimised.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n The Kimberley region, Western Australia.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Aboriginal People in the Kimberley with DFD.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n A mixed methods study design was used, incorporating quantitative analysis of primary and outpatient care presentations and hospitalisation data collected from in\u2010depth medical record reviews (\n n<\/jats:italic>\n \u2009=\u200935) and semi\u2010structured interviews with participants (\n n<\/jats:italic>\n \u2009=\u200928).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n This study highlighted that DFD in the Kimberley has a significant impact on individuals and communities. While primary and outpatient services play a key role in DFD care, there is an opportunity to strengthen preventive foot care services. Participants valued flexibility and autonomy in managing their care, especially with the support of Aboriginal Community Controlled Health Services (ACCHS). Recommendations to improve DFD care are provided, incorporating the perspectives of patients and of the health professionals who participated in the data interpretation workshop. These include facilitating patient self\u2010care, expanding high\u2010quality foot care within ACCHS, strengthening support for hospitalised patients, and advocating for upstream service improvements.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Addressing geographical and systemic barriers through improved patient education, better access to primary care resources, and increased patient choice may enhance autonomy and long\u2010term DFD outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ajr.70184","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:25:41Z","timestamp":1775193941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Healing Steps on Country\u2014Exploring Care Pathways for Aboriginal People in the Kimberley With Diabetes\u2010Related Foot Disease"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3315-3497","authenticated-orcid":false,"given":"Sophie","family":"Moustaka","sequence":"first","affiliation":[{"name":"Kimberley Aboriginal Medical Services Broome Western Australia Australia"},{"name":"University of Notre Dame Australia Fremantle Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala","family":"Mckay","sequence":"additional","affiliation":[{"name":"Kimberley Aboriginal Medical Services Broome Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Stapleton","sequence":"additional","affiliation":[{"name":"Kimberley Aboriginal Medical Services Broome Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie","family":"Millroy","sequence":"additional","affiliation":[{"name":"Kimberley Aboriginal Medical Services Broome Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Fairfull","sequence":"additional","affiliation":[{"name":"Kimberley Aboriginal Medical Services Broome Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantelle","family":"Carr","sequence":"additional","affiliation":[{"name":"Boab Health Services Broome Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Western Australian Country Health Service: High Risk Foot Clinic Broome Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Kimberley Aboriginal Medical Services Broome Western Australia Australia"},{"name":"The Rural Clinical School of Western Australia Broome Western Australia Australia"},{"name":"Kimberley Renal Services Broome Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.01198"},{"key":"e_1_2_12_3_1","volume-title":"Burden of Lower Limb Amputations due to Diabetes in Australia: Australian Burden of Disease Study 2011 [Internet]","author":"Australian Institute of Health and Welfare","year":"2017"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-2189"},{"key":"e_1_2_12_5_1","volume-title":"Australian Evidence\u2010Based Guidelines for Diabetes\u2010Related Foot Disease [Internet]","author":"Lazzarini P. A.","year":"2021"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2007.00392.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3747"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-021-00764-z"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2010.tb03571.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2025-098999"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2024.03.011"},{"key":"e_1_2_12_12_1","volume-title":"Australia and New Zealand Dialysis and Transplant Registry","author":"Bateman S.","year":"2023"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzae120"},{"key":"e_1_2_12_14_1","volume-title":"IWGDF Guidelines on the Prevention and Management of Diabetes\u2010Related Foot Disease [Internet]","author":"Schaper N. C.","year":"2023"},{"key":"e_1_2_12_15_1","volume-title":"Australian Atlas of Healthcare Variation [Internet]","author":"Australian Commission on Safety and Quality in Health Care and National Health Performance","year":"2015"},{"key":"e_1_2_12_16_1","volume-title":"Kimberley Needs Assessment 2022\u20132024 [Internet]","author":"WA Primary Health Alliance","year":"2024"},{"key":"e_1_2_12_17_1","volume-title":"Kimberley: 2021 Census Aboriginal and\/or Torres Strait Islander People [Internet]","author":"Australian Bureau of Statistics","year":"2021"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-09943-4"},{"key":"e_1_2_12_19_1","volume-title":"Kimberley Health Profile 2018 [Internet]","author":"Anderson C.","year":"2018"},{"key":"e_1_2_12_20_1","volume-title":"Australian Diabetes\u2010Related Foot Disease Strategy 2018\u20132022: The First Step Towards Ending Avoidable Amputations Within a Generation [Internet]","author":"Netten J. J.","year":"2017"},{"key":"e_1_2_12_21_1","volume-title":"Guidance Concerning the Use of Glycated Haemoglobin for the Diagnosis of Diabetes Mellitus [Internet]","author":"Australian Diabetes Society","year":"2023"},{"key":"e_1_2_12_22_1","volume-title":"Diabetes Type II in Adults [Internet]","author":"Kimberley Aboriginal Health Planning Forum","year":"2023"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-019-0326-1"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1168568"},{"key":"e_1_2_12_25_1","volume-title":"Factors That Influence Participation in Self\u2010Management of Wound Care in Three Indigenous Communities in Western Australia: Clients' Perspectives","author":"Eades A. M.","year":"2008"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14219"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2015-000158"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1146-4-S1-P1"},{"issue":"3","key":"e_1_2_12_29_1","article-title":"Clinical Outcomes Among Patients With Chronic Kidney Disease Hospitalized With Diabetic Foot Disorders: A Nationwide Retrospective Study","volume":"4","author":"Salim M.","year":"2021","journal-title":"Endocrinology and Metabolism"},{"key":"e_1_2_12_30_1","article-title":"A Qualitative Exploration of the Experiences of Aboriginal and Torres Strait Islander People Using a Real\u2010Time Video\u2010Based Telehealth Service for Diabetes\u2010Related Foot Disease","volume":"24","author":"Graham K.","year":"2024","journal-title":"Rural and Remote Health"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foot.2021.101872"},{"issue":"1","key":"e_1_2_12_32_1","first-page":"225","article-title":"Practical Guidelines on the Management and Prevention of the Diabetic Foot 2011","volume":"28","author":"Bakker K.","year":"2012","journal-title":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"},{"key":"e_1_2_12_33_1","volume-title":"Foot Care for People With Diabetes: Western Australia Standards, 2024 [Internet]","author":"Department of Health, Western Australia","year":"2024"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-022-00524-9"},{"key":"e_1_2_12_35_1","volume-title":"Community Foot Care Hubs [Internet]","author":"Queensland Government","year":"2025"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajr.70014"},{"issue":"2","key":"e_1_2_12_37_1","first-page":"65","article-title":"Exploring Wellbeing in Individuals With Diabetic Foot Ulcers: The Patient Perspective","volume":"22","author":"Connell L.","year":"2021","journal-title":"Journal of Wound Management"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajs4.96"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.33235\/wpr.30.2.82-90"},{"key":"e_1_2_12_40_1","volume-title":"Aboriginal Patient Take Own Leave: Review and Recommendations for Improvement [Internet]","author":"Aboriginal Health Policy Directorate","year":"2018"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-021-06925-z"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-024-02560-w"}],"container-title":["Australian Journal of Rural Health"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajr.70184","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajr.70184","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajr.70184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:45:27Z","timestamp":1782099927000},"score":7.5967255,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajr.70184"}},"issued":{"date-parts":[[2026,4]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/ajr.70184"],"URL":"https:\/\/doi.org\/10.1111\/ajr.70184","archive":["Portico"],"ISSN":["1038-5282","1440-1584"],"issn-type":[{"value":"1038-5282","type":"print"},{"value":"1440-1584","type":"electronic"}],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70184"},{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T14:53:14Z","timestamp":1771944794337,"version":"3.50.1"},"reference-count":0,"publisher":"CSIRO PublishingLocked Bag 10, Clayton South VIC 3169, Australia","isbn-type":[{"value":"9781486307470","type":"print"},{"value":"9781486307487","type":"electronic"},{"value":"9781486307494","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2018,3]]},"abstract":"The Hepialidae (Ghost Moths) are a family of often spectacular micro-moths. The Australian region is one of the hot spots for hepialid diversity and the fauna is divided into three groups: primitive Hepialidae with small, often overlooked species; oxycanine Hepialidae, containing the large and poorly known genus Oxycanus and its allies; and finally the hepialine Hepialidae, which span from stunning, green Splendid Ghost Moths in the genus Aenetus, to the enormous moths in the genera Zelotypia and Abantiades (which include some of the most impressive insects in the world), to smaller, drab pest species in the genus Oncopera. Splendid Ghost Moths and Their Allies is the first work to provide comprehensive information about the taxonomy, biology, diversity and morphology of all 70 Australian hepialine Hepialidae species, including the descriptions of 15 species and one genus new to science. Each species is illustrated with colour photographs of males and females and drawings of the genitalia, and the book also contains identification keys to genera and species. Distribution maps and detailed information on where each species is found are included, as well as a species richness map for the group in Australia. This book is an invaluable reference for moth enthusiasts, professional entomologists and nature conservationists alike.<\/jats:p>","DOI":"10.1071\/9781486307487","type":"monograph","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T17:45:56Z","timestamp":1549907156000},"source":"Crossref","is-referenced-by-count":8,"title":["Splendid Ghost Moths and Their Allies"],"prefix":"10.1071","author":[{"given":"Thomas J.","family":"Simonsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","language":"en","deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T06:19:56Z","timestamp":1770099596000},"score":7.596575,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/books\/book\/866\/Splendid-Ghost-Moths-and-Their-AlliesA-Revision-of"}},"subtitle":["A Revision of Australian\n Abantiades<\/i>\n ,\n Oncopera<\/i>\n ,\n Aenetus<\/i>\n ,\n Archaeoaenetus<\/i>\n and\n Zelotypia<\/i>\n (Hepialidae)"],"editor":[{"given":"Marianne","family":"Horak","sequence":"additional","affiliation":[{"name":"Australian National Insect Collection CSIRO NRCA , GPO Box 1700 Canberra ACT 2601, Australia"}],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"M. F.","family":"Braby","sequence":"additional","affiliation":[{"name":"Canberra, Australia"},{"name":"Canberra, Australia"},{"name":"Brisbane, Australia"},{"name":"Washington DC, USA"},{"name":"London, UK"},{"name":"Canberra, Australia"}],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"E. D.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Canberra, Australia"},{"name":"Canberra, Australia"},{"name":"Brisbane, Australia"},{"name":"Washington DC, USA"},{"name":"London, UK"},{"name":"Canberra, Australia"}],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"R. L.","family":"Kitching","sequence":"additional","affiliation":[{"name":"Canberra, Australia"},{"name":"Canberra, Australia"},{"name":"Brisbane, Australia"},{"name":"Washington DC, USA"},{"name":"London, UK"},{"name":"Canberra, Australia"}],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"S. E.","family":"Miller","sequence":"additional","affiliation":[{"name":"Canberra, Australia"},{"name":"Canberra, Australia"},{"name":"Brisbane, Australia"},{"name":"Washington DC, USA"},{"name":"London, UK"},{"name":"Canberra, Australia"}],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"M. J.","family":"Scoble","sequence":"additional","affiliation":[{"name":"Canberra, Australia"},{"name":"Canberra, Australia"},{"name":"Brisbane, Australia"},{"name":"Washington DC, USA"},{"name":"London, UK"},{"name":"Canberra, Australia"}],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"M. 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This preliminary evaluation examines participants' and facilitators' perceptions of a redeveloped MBCP. Participants reported significant improvements in their ability to manage stress, understand the impact of their use of violence, and\u00a0apply skills to repair the impact of their use of violence. Facilitators reported that peer support was an important component contributing to changes in the participants' knowledge, awareness, attitudes, and behaviours. 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The small cell sample analyzed makes this a low precision test. We report the utility of an automated FISH method, called \u201cimmuno\u2010flowFISH\u201d, to detect plasma cells with adverse prognostic risk del(17p) in bone marrow and blood samples of patients with myeloma.<\/jats:p><\/jats:sec>Methods<\/jats:title>Bone marrow (n<\/jats:italic>\u2009=\u200931) and blood (n<\/jats:italic>\u2009=\u200919) samples from 35 patients with myeloma were analyzed using immuno\u2010flowFISH. Plasma cells were identified by CD38\/CD138\u2010immunophenotypic gating and assessed for the 17p locus and centromere of chromosome 17. Cells were acquired on an AMNIS ImageStreamX MkII imaging flow cytometer using INSPIRE software.<\/jats:p><\/jats:sec>Results<\/jats:title>Chromosome 17 abnormalities were identified in CD38\/CD138\u2010positive cells in bone marrow (6\/31) and blood (4\/19) samples when the percent plasma cell burden ranged from 0.03% to 100% of cells. Abnormalities could be identified in 14.5%\u2013100% of plasma cells.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The \u201cimmuno\u2010flowFISH\u201d imaging flow cytometric method could detect del(17p) in plasma cells in both bone marrow and blood samples of myeloma patients. This method was also able to detect gains and losses of chromosome 17, which are also of prognostic significance. The lowest levels of 0.009% (bone marrow) and 0.001% (blood) for chromosome 17 abnormalities was below the detection limit of current FISH method. This method offers potential as a new means of identifying these prognostically important chromosomal defects, even when only rare cells are present and for serial disease monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14248","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T08:26:25Z","timestamp":1708503985000},"page":"495-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Imaging flow cytometric detection of del(17p<\/scp>) in bone marrow and circulating plasma cells in multiple myeloma"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8347-4302","authenticated-orcid":false,"given":"Thomas I.","family":"Mincherton","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie J.","family":"Lam","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine Nedlands Western Australia Australia"},{"name":"Haematology Department Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Clarke","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences The University of Western Australia Crawley Western Australia Australia"},{"name":"PathWest Laboratory Medicine Nedlands Western Australia Australia"},{"name":"Haematology Department Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0442-6987","authenticated-orcid":false,"given":"Henry Y. 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The program is part of the Government\u2019s Strategic Basin Initiative under its Gas-fired Recovery agenda, implemented as a post-COVID19 response to stimulate the economy. This program will deliver regional geological and environmental assessments underpinned by transparent, trusted baseline geological and environmental data, commencing in the north Bowen and Galilee and the Cooper and Adavale Basins. This repository of information is to be used in support of bringing forward energy and mineral developments in basins identified by the Government as strategic. This paper discusses how coupling resource assessments with baseline information such as groundwater, geology, energy and mineral resources, surface water and protected environmental matters, can be used to support exploration and development decisions by industry, regulators and other stakeholders. For example, by establishing a regional baseline resource assessment, through prospectivity play mapping, environmental assessments can be prioritised to match resource prospectivity. In anticipating future development scenarios, potential impacts on environmental assets, including groundwater, can be assessed in advance and with key knowledge gaps identified for redress. This approach aims to optimise the regulatory pathway to resource development and increase regulatory efficiency as future development opportunities arise across the scope of petroleum, minerals, carbon capture and storage, and hydrogen storage and production. 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Individuals with FASD are more likely to engage with the law, including being placed in detention, than individuals without FASD. Young people who were sentenced to detention participated in a FASD prevalence study in Western Australia. The diagnosis of FASD requires a multidisciplinary assessment and confirmation of maternal alcohol consumption during pregnancy. Obtaining accurate assessment of PAE for young people participating in the study was challenging.<\/jats:p><\/jats:sec>Methods<\/jats:title>An interview with the birth mother or other responsible adult for young people sentenced to detention in Western Australia was conducted as part of the FASD assessment. The Alcohol Use Disorders Identification Test consumption subset (AUDIT\u2010C), other relevant questions, and documentary evidence were used to assess PAE. PAE was categorized according to the Australian Guide to the Diagnosis of FASD: no PAE reported, confirmed or confirmed high\u2010risk, or unknown.<\/jats:p><\/jats:sec>Results<\/jats:title>Among the 101 participants, information on PAE was unable to be obtained for 13 (13%) young people. Of the remaining 88 participants with information of PAE, 41 reported no PAE and 47 had confirmed PAE.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Accurately assessing prenatal alcohol consumption is challenging in any setting, but it is exceptionally challenging when assessed 13 to 17\u00a0years retrospectively as part of a FASD assessment for a young person sentenced to detention. Recording and recoding detailed qualitative responses was required to provide an accurate assessment of PAE using the AUDIT\u2010C. Standardized recording of PAE in antenatal and birth records would facilitate later assessments for FASD and provide opportunities for advice and support for women who continue to drink during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13926","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T14:25:57Z","timestamp":1542205557000},"page":"309-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Challenges in Accurately Assessing Prenatal Alcohol Exposure in a Study of Fetal Alcohol Spectrum Disorder in a Youth Detention Center"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8784-7295","authenticated-orcid":false,"given":"Jacinta","family":"Freeman","sequence":"first","affiliation":[{"name":"Telethon Kids Institute University of Western Australia Perth Western Australia 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In one of our example grammar and vocabulary lessons, the Thinking Head instructs the student to move a tiger to a lake\u2014a student moving the toy tiger in the real world effectively moves a virtual tiger in the virtual arena. This type of interaction is beneficial for computer-based language learning especially because we are able to see a student has successfully understood the directions if the tiger is moved to the vicinity of the virtual lake. Physical movement helps the learner to internalise the novel relationships in the second language. We also provide for additional forms of communication, including dialogue with an embodied conversational agent and writing stories using markers on a whiteboard. 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In wave\u2010dominated environments, an understanding of the mean wave\u2010driven flows generated within and above canopies is important, as it governs material transport (e.g., of nutrients, sediment, and biota). However, until recently the effect of submerged canopies on wave\u2010current interactions and the resulting mean (wave\u2010averaged) flow dynamics has received relatively little attention. In this study, a combination of wave flume experiments and numerical modeling is used to investigate the wave\u2010induced mean flow profiles in the presence of a submerged canopy. The measured velocities and vegetation forces were used to derive bulk drag and inertia coefficients, and to validate a nonhydrostatic 2DV wave\u2010flow model. The numerical model results were used to conduct an in\u2010depth analysis of the mean horizontal momentum terms responsible for driving the mean (horizontal) flow within and above the submerged canopies. We show that the mean canopy hydrodynamics are driven by vertical gradients in wave and turbulent Reynolds stresses, balanced by the mean canopy drag forces. The wave Reynolds stress gradient is the dominant force driving the in\u2010canopy mean flow and is directly related to the vorticity that is generated when the wave orbital motions become rotational near the canopy interface. This study provides new insight in the mechanisms responsible for wave\u2010driven mean flows within submerged canopies and guidance for how these hydrodynamics can be predicted in coastal wave\u2010circulation models.<\/jats:p>","DOI":"10.1029\/2019jc015935","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T11:11:03Z","timestamp":1582024263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Wave\u2010Driven Mean Flow Dynamics in Submerged Canopies"],"prefix":"10.1029","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5013-2592","authenticated-orcid":false,"given":"Arnold","family":"van Rooijen","sequence":"first","affiliation":[{"name":"School of Earth Sciences University of Western Australia Perth Western Australia Australia"},{"name":"UWA Oceans Institute University of Western Australia Perth Western Australia Australia"},{"name":"ARC Centre of Excellence for Coral Reef Studies University of Western Australia Perth Western Australia Australia"},{"name":"Deltares Delft Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7080-8406","authenticated-orcid":false,"given":"Ryan","family":"Lowe","sequence":"additional","affiliation":[{"name":"School of Earth Sciences University of Western Australia Perth Western Australia Australia"},{"name":"UWA Oceans Institute University of Western Australia Perth Western Australia Australia"},{"name":"ARC Centre of Excellence for Coral Reef Studies University of Western Australia Perth Western Australia Australia"},{"name":"Oceans Graduate School University of Western Australia Perth Western Australia Australia"},{"name":"Wave Energy Research Centre University of Western Australia Albany Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6409-3926","authenticated-orcid":false,"given":"Dirk P.","family":"Rijnsdorp","sequence":"additional","affiliation":[{"name":"UWA Oceans Institute University of Western Australia Perth Western Australia Australia"},{"name":"Oceans Graduate School University of Western Australia Perth Western Australia Australia"},{"name":"Wave Energy Research Centre University of Western Australia Albany Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6690-8922","authenticated-orcid":false,"given":"Marco","family":"Ghisalberti","sequence":"additional","affiliation":[{"name":"UWA Oceans Institute University of Western Australia Perth Western Australia Australia"},{"name":"Oceans Graduate School University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2662-6282","authenticated-orcid":false,"given":"Niels G.","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Deltares Delft Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9213-1539","authenticated-orcid":false,"given":"Robert","family":"McCall","sequence":"additional","affiliation":[{"name":"Deltares Delft Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"13","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lno.10368"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/2016JC012446"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoleng.2010.11.027"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1061\/(ASCE)EM.1943-7889.0001087"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advwatres.2018.11.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advwatres.2018.10.008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-8018(03)00040-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1061\/(ASCE)0733-950X(1984)110:1(67)"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coastaleng.2005.10.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1029\/2004WR003475"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coastaleng.2019.04.014"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-7714(05)80039-3"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1029\/2000JC900084"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10652-009-9161-4"},{"key":"e_1_2_8_16_1","unstructured":"Goring D. G.(1979).Tsunamis\u2010the propagation of long waves onto a shelf. PhD thesis California Institute of Technology. Report No. KH\u2010R\u201038."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4872160"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coastaleng.2014.02.009"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coastaleng.2016.07.009"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coastaleng.2019.04.007"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1061\/(ASCE)0733-950X(1993)119:1(30)"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-030937-8.50016-7"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-85567-2"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.1953.0006"},{"key":"e_1_2_8_25_1","unstructured":"L\u00f3pez F. &Garc\u00eda M. 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Technical Report WRP\u2010CP\u201010 University of Illinois at Urbana\u2010Champaign USA."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1029\/98WR01922"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1029\/2004JC002788"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4319\/lo.2008.53.6.2668"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1029\/2010JC006345"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgrc.20162"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coastaleng.2013.05.007"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coastaleng.2003.11.003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ngeo2251"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.2112\/1551-5036-36.sp1.506"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-fluid-120710-101048"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1029\/2000JC900145"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3091.2006.00772.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1142\/1269"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmarsys.2005.08.003"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1061\/(ASCE)WW.1943-5460.0000251"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1029\/2010JC006797"},{"key":"e_1_2_8_42_1","volume-title":"The dynamics of the upper ocean","author":"Phillips O. 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To determine if two exercise prescriptions exert differential metabolic benefits in insulin sensitive tissues, we compared isocaloric programs of constant-moderate endurance (END) and high intensity interval training (HIIT), in a mouse model of diet-induced obesity. Male 10 week old C57BL\/6 mice were fed a high fat diet (HFD; 45% kcal fat) ab libitum for 10 weeks, achieving 25% excess weight, and for a further 10 weeks they then underwent isocaloric END or HIIT (3x40min sessions\/week). Untrained HFD and chow-fed mice acted as controls. At 30 weeks of age, mice were sacrificed and quadriceps muscle, subcutaneous adipose tissue (SAT) and liver were excised. Neither END or HIIT altered the body weight or the fat\/lean mass proportion in HFD mice. An insulin tolerance test (0.65 IU\/kg*BW) showed HIIT but not END improved insulin sensitivity in HFD mice (p&lt;0.vs. untrained). In quadricep, HFD induced down-regulation of high-molecular weight adiponectin protein, which was similarly normalized by END and HIIT. In contrast HIIT but not END reversed the HFD-driven downregulation of adiponectin receptor 1 (AdipoR1; p&lt;0.05). In SAT, both programs tended to decrease collagen VI protein (p=0.08), whereas only HIIT induced an upregulation in mRNA (3-fold vs. HFD untrained) and protein (2-fold vs. HFD untrained) of UCP1. In liver, only END was able to reverse the collagen I accumulation (2-fold; p&lt;0.05) and downregulation of CTGF (0.5-fold; protein) seen in HFD untrained mice (p&lt;0.05). Our results suggest that HIIT may promote better systemic metabolic effects, compared to END during high-fat fed conditions, which could be explained by the normalization of muscle AdipoR1 and higher UCP1 induction in SAT. However, END was more effective in normalizing liver changes, suggesting differential metabolic effects of END and HIIT during obesity.<\/jats:p>\n \n Disclosure<\/jats:title>\n S.F. Martinez-Huenchullan: None. L.A. Ban: None. L.F. Olaya: None. B.R. Maharjan: None. C. Tam: None. S. McLennan: None. S.M. Twigg: Advisory Panel; Self; Abbott. Consultant; Self; Abbott. Advisory Panel; Self; Novo Nordisk Inc., Sanofi-Aventis, AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company. Speaker's Bureau; Self; AstraZeneca, Merck Sharp & Dohme Corp.. Other Relationship; Self; Abbott.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db18-746-p","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T18:57:35Z","timestamp":1529693855000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Constant-Moderate and High-Intensity Interval Training Induce Differential Metabolic Benefits on Insulin-Sensitive Tissues in High-Fat Fed Mice"],"prefix":"10.2337","volume":"67","author":[{"given":"SERGIO F.","family":"MARTINEZ-HUENCHULLAN","sequence":"first","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LINDA A.","family":"BAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUISA F.","family":"OLAYA","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BABU R.","family":"MAHARJAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHARMAINE","family":"TAM","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUSAN","family":"MCLENNAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN M.","family":"TWIGG","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/746-P\/58287\/Constant-Moderate-and-High-Intensity-Interval","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/746-P\/58287\/Constant-Moderate-and-High-Intensity-Interval","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:09:33Z","timestamp":1647166173000},"score":7.595278,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/67\/Supplement_1\/746-P\/58287\/Constant-Moderate-and-High-Intensity-Interval"}},"issued":{"date-parts":[[2018,7,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db18-746-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2018,7,1]]},"article-number":"746-P"},{"indexed":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T05:15:18Z","timestamp":1678511718451},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Supplement 4","content-domain":{"domain":["www.auajournals.org"],"crossmark-restriction":true},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1097\/01.ju.0000555482.96032.85","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T05:40:57Z","timestamp":1556084457000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["MP18-20\u2003CAN THE USE OF RECTAL SWABS PREVENT SEPSIS FROM FLUOROQUINOLONE RESISTANT ESCHERICHIA COLI IN MEN UNDERGOING TRANSRECTAL ULTRASOUND-GUIDED PROSTATE BIOPSY?"],"prefix":"10.1097","volume":"201","author":[{"given":"Duncan","family":"Self*","sequence":"first","affiliation":[{"name":"Gosford, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashe","family":"DeBiasio","sequence":"additional","affiliation":[{"name":"Gosford, 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Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534712024123?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534712024123?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2012.02.2050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:09:40Z","timestamp":1651201780000},"score":7.595278,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2012.02.2050"}},"issued":{"date-parts":[[2012,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1016\/j.juro.2012.02.2050"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2012.02.2050","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2012,4]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:50Z","timestamp":1753889810623,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Background: Previous studies suggest that NLRP3 inflammasome activation could have pathological relevance in diabetic kidney disease (DKD). A recent study demonstrated that NLRP3 inhibition in a preventional approach in db\/db mice provided reno-protection, potentially via a ROS dependent mechanism. We aimed to examine the therapeutical potential of the NLRP3 inflammasome inhibitor, MCC950 in a more clinically relevant interventional approach in a model of DKD and its impact on renal pathology.<\/jats:p>\n Methods: Diabetes was induced by streptozotocin in ApoE-\/- mice. A subgroup of control and diabetic mice was treated with MCC950 (5mg\/kg\/3 times\/week). Treatment was commenced after 5 or 9 weeks of diabetes and continued for another 5 or 9 weeks for the assessment of renal gene expression as well its impact on albuminuria and renal morphology, respectively.<\/jats:p>\n Results: Diabetes-induced mesangial expansion was further increased in MCC950 treated diabetic mice when compared to untreated diabetic group (18.9\u00b10.6% vs. 16.3\u00b10.7%, respectively). MCC950 treated diabetic mice showed a trend of increased albuminuria when compared to untreated diabetic mice (43\u00b19 vs. 31\u00b15 ug\/24hrs, respectively). Gene expression of markers of fibrosis (fibronectin, collagen IV, \u03b1-smooth muscle actin and PCNA) and pro-oxidant enzymes (Nox2 and Nox4) were upregulated in diabetic mice compared to nondiabetic controls. These changes were further upregulated in MCC950-treated diabetic mice when compared to untreated diabetic mice. In addition, mRNA expression of pro-inflammatory markers (MCP-1 and IL-6) were increased in untreated diabetic animals as compared to controls and MCC950 treatment did not show additional upregulation of these parameters.<\/jats:p>\n Conclusions: The present study indicates that inhibition of the NLRP3 inflammasome by MCC950 after establishment of disease, may not have a reno-protective effect. Our data rather shows an adverse effect of this drug at least in this model of DKD.<\/jats:p>\n \n Disclosure<\/jats:title>\n J.A. \u00d8stergaard: None. J.C. Jha: None. A. Sharma: None. A. Dai: None. M.E. Cooper: Advisory Panel; Self; AstraZeneca, Boehringer Ingelheim International GmbH, Mundipharma International. Research Support; Self; Boehringer Ingelheim International GmbH, Novo Nordisk A\/S. Speaker\u2019s Bureau; Self; AstraZeneca, Merck Sharp & Dohme Corp., Novartis AG, Sanofi-Aventis, Servier. J.B. de Haan: Research Support; Self; Bayer Inc., Reata Pharmaceuticals. K. Jandeleit-Dahm: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-479-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:52Z","timestamp":1592238592000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["479-P: Inhibition of the NLRP3 Inflammasome by MCC950 Accelerates Renal Injury in Diabetes Model"],"prefix":"10.2337","volume":"69","author":[{"given":"JAKOB A.","family":"\u00d8STERGAARD","sequence":"first","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAY C.","family":"JHA","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ARPEETA","family":"SHARMA","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AOZHI","family":"DAI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK E.","family":"COOPER","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUDY B.","family":"DE HAAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KARIN","family":"JANDELEIT-DAHM","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/479-P\/57929\/479-P-Inhibition-of-the-NLRP3-Inflammasome-by","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/479-P\/57929\/479-P-Inhibition-of-the-NLRP3-Inflammasome-by","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:46:42Z","timestamp":1647164802000},"score":7.595278,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/479-P\/57929\/479-P-Inhibition-of-the-NLRP3-Inflammasome-by"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-479-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"479-P"},{"indexed":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T15:40:40Z","timestamp":1656085240831},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"14_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2016,7,15]]},"abstract":"Abstract<\/jats:title>\n Amplification of the MYCN oncogene, a member of the MYC family of transcriptional regulators, is one of the most powerful prognostic markers identified for poor outcome in neuroblastoma, the most common extracranial solid cancer in childhood. While MYCN has been established as a key driver of malignancy in neuroblastoma, the underlying molecular mechanisms are poorly understood. Transcription factor activating enhancer binding protein-4 (TFAP4), which plays important roles in cancer progression, has been reported to be a direct transcriptional target of MYC. In this study, we have shown that high expression of TFAP4 in primary neuroblastoma patients is associated with poor clinical outcome and furthermore that siRNA-mediated suppression of TFAP4 in MYCN-expressing neuroblastoma cells impaired migration and colony formation, and led to an increased proportion of cells in G1\/S phase of the cell cycle. Chromatin immunoprecipitation and luciferase reporter assays demonstrated that TFAP4 expression is positively regulated by MYCN through direct promoter binding. In addition, when MYCN was overexpressed in neuroblastoma cells, TFAP4 was required for the observed increase in cell migration. Microarray analysis identified genes regulated by both MYCN and TFAP4 in neuroblastoma cells, including Phosphoribosyl-pyrophosphate synthetase-2 (PRPS2) and Syndecan-1 (SDC1), which are involved in cancer cell proliferation and metastasis. Overall this study unveils a complex regulatory circuit in which MYCN by elevating TFAP4 expression, cooperates with it to control a specific set of genes involved in tumor progression. These findings highlight the existence of a MYCN-TFAP4 axis in MYCN-driven neuroblastoma as well as identifying relevant therapeutic targets for aggressive forms of this disease.<\/jats:p>\n Citation Format: Chengyuan Xue, Denise M. Yu, Samuele Gherardi, Jessica Koach, Giorgio Milazzo, Laura Gamble, Bing Liu, Amanda Russell, Tao Liu, Belamy B. Cheung, Glenn M. Marshall, Giovanni Perini, Michelle Haber, Murray D. Norris. MYCN and TFAP4 promote neuroblastoma malignancy by cooperating in the regulation a subset of target genes involved in cancer cell growth and metastasis. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2450.<\/jats:p>","DOI":"10.1158\/1538-7445.am2016-2450","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T17:58:31Z","timestamp":1469555911000},"page":"2450-2450","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Abstract 2450: MYCN and TFAP4 promote neuroblastoma malignancy by cooperating in the regulation a subset of target genes involved in cancer cell growth and metastasis"],"prefix":"10.1158","volume":"76","author":[{"given":"Chengyuan","family":"Xue","sequence":"first","affiliation":[{"name":"1Children's Cancer Inst. 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Design<\/jats:title>\n Retrospective longitudinal cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n The Western Australia tertiary paediatric EI service.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n EI clinicians, consumers and children using the EI service.<\/jats:p>\n <\/jats:sec>\n \n Outcome measures<\/jats:title>\n Knowledge translation strategies including consumer perspectives, clinician training and Communities of Practice (CoP) guided implementation. We measured changes in referral number and age, delivery of early detection and intervention following the implementation of the guidelines. Exposure to adverse childhood experiences (ACEs), appointment non-attendance (DNA) rates, remoteness and socioeconomic quintiles were used to measure social determinants of health using negative binomial (Incidence Rate Ratios, IRR) and logistic regression (Odds Ratios, ORs).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Ten consumers participated in Focus Groups, 100 clinicians were trained and 22 clinicians established a monthly CoP. Referrals increased fourfold to 511 children. Corrected gestational age at referral decreased from a median of 16.1 to 5.1 months (p<0.001) and at first appointment from 18.8 to 6.8 months (p<0.001). Children living in social disadvantage had the highest DNA risk (quintile 1 vs 5: IRR 2.2, 95%\u2009CI 1.1 to 4.6, p=0.037). Children exposed to ACEs had higher odds of living in social disadvantage (quintile 1 vs 5, OR=3.8, 95%\u2009CI 1.4 to 10.0, p=0.007). No significant association was found between remoteness and DNA rate or ACE score.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Implementation strategies reduced referral age and improved the delivery of early detection assessments. Further investigation of the association between social disadvantage, DNA risk and ACE score is required in the development of a state-wide early detection network.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-063296","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T09:32:19Z","timestamp":1669368739000},"page":"e063296","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["From guidelines to practice: A retrospective clinical cohort study investigating implementation of the early detection guidelines for cerebral palsy in a state-wide early intervention service"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6795-1466","authenticated-orcid":false,"given":"Sue-Anne","family":"Davidson","sequence":"first","affiliation":[{"name":"School of Allied Health, Curtin University, Perth, Western Australia, Australia"},{"name":"Kids Rehab WA, Perth Children's Hospital, Nedlands, Western Australia, Australia"},{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roslyn","family":"Ward","sequence":"additional","affiliation":[{"name":"School of Allied Health, Curtin University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Elliott","sequence":"additional","affiliation":[{"name":"School of Allied Health, Curtin University, Perth, Western Australia, Australia"},{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtenay","family":"Harris","sequence":"additional","affiliation":[{"name":"School of Allied Health, Curtin University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Bear","sequence":"additional","affiliation":[{"name":"Institute for Health Research, Notre Dame University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashleigh","family":"Thornton","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"},{"name":"Division of Paediatrics, Medical School, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Salt","sequence":"additional","affiliation":[{"name":"School of Allied Health, Curtin University, Perth, Western Australia, Australia"},{"name":"Kids Rehab WA, Perth Children's Hospital, Nedlands, Western Australia, Australia"},{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Valentine","sequence":"additional","affiliation":[{"name":"School of Allied Health, Curtin University, Perth, Western Australia, Australia"},{"name":"Kids Rehab WA, Perth Children's Hospital, Nedlands, Western Australia, Australia"},{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"2025121509125578000_12.11.e063296.1","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.3390\/jcm8101599","article-title":"Early diagnosis and classification of cerebral palsy: an historical perspective and barriers to an early diagnosis","volume":"8","author":"te Velde","year":"2019","journal-title":"J Clin Med"},{"key":"2025121509125578000_12.11.e063296.2","unstructured":"ACPR . 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This is due to a lower number of Aboriginal children attending ECE programs compared to non-Aboriginal children. Attending ECE programs sets children up for school success and is an indicator for positive life outcomes in later life. Therefore, we sought to co-design and implement a program that encourages Aboriginal children and families to attend ECE programs, known as Moort Dandjoo Kaadadjiny. Since 2021, 57 children have attended, and 27 participants yarned about their experience with the program. These yarns revealed the importance of building trust, being Aboriginal led, and holistic engagement in Aboriginal culture as essential in co-designing culturally safe ECE programs. This program serves as a foundation for developing culturally appropriate ECE programs for Aboriginal children and families to ensure Aboriginal kids grow up strong in their culture and identity.<\/jats:p>","DOI":"10.1177\/18369391241274795","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T06:05:45Z","timestamp":1724133945000},"page":"97-109","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Moort dandjoo kaadadjiny: Growing up Aboriginal kids strong in their culture and identity"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5665-6506","authenticated-orcid":false,"given":"Theoni","family":"Whyman","sequence":"first","affiliation":[{"name":"University of Western Australia, Telethon Kids Institute, 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We performed random effects network meta\u2010analyses and calculated risk ratios (RRs) between treatments. Bias was assessed using the revised Cochrane risk\u2010of\u2010bias tool.<\/jats:p><\/jats:sec>Results<\/jats:title>We identified 3,775 records, of which 29 publications (27 trials) were included. When compared to placebo plus prophylaxis, the RR of flares ranged from 1.08 (95% confidence interval [CI] 0.87\u20131.33) for febuxostat 40 mg plus prophylaxis to RR 2.65 [95% CI 1.58\u20134.45] for febuxostat 80 mg plus lesinurad 400 mg plus prophylaxis. Compared to ULT alone, the RR of flares was lower for ULT plus rilonacept 160 mg (RR 0.35 [95% CI 0.25\u20130.50]), ULT plus rilonacept 80 mg (RR 0.43 [95% CI 0.31\u20130.60]) and ULT plus colchicine (RR 0.50\u00a0[95% CI 0.35\u20130.72]). There was limited evidence for other flare prophylaxis and on prophylaxis harms and optimal duration. Primarily because of missing outcome data and bias in the selection of reported results, 71.4% and 63.4% of studies were assessed as high risk of bias for flares and adverse events, respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The RR of flares when introducing ULT varies depending on ULT drug and dosing strategies. There were limited data on ULT escalation. Flare prophylaxis with colchicine and rilonacept reduces flare incidence. More research is required on the harms and optimal duration of prophylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25309","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T01:29:50Z","timestamp":1706837390000},"page":"871-881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Comparative Risk of Gout Flares When Initiating or Escalating Various Urate\u2010Lowering Therapy: A Systematic Review With Network Meta\u2010Analysis"],"prefix":"10.1002","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8758-3602","authenticated-orcid":false,"given":"Dorsa","family":"Maher","sequence":"first","affiliation":[{"name":"University of South Australia and Southern Adelaide Local Health Network Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Reeve","sequence":"additional","affiliation":[{"name":"University of 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KIR genes exhibit extensive variation through variable gene content, copy number, and allele polymorphism. The combination of KIR genes and their ligands is implicated in various clinical settings including haematopoietic stem cell and solid organ transplant, and infectious disease progression. KIR gene content has been used in the selection of optimal stem cell donors with haplotype variations in recipient and donor giving differential clinical outcomes. With the introduction of massively parallel clonal next generation sequencing and single molecule long read third generation sequencing, allele level determination of KIR genotypes has become feasible. We describe a method for amplicon\u2010based long read sequencing on the Oxford Nanopore Technologies platform that provides largely unambiguous allele level typing of KIR genes. The method was validated using DNA extracted from 48 10th International Histocompatibility Workshop (IHWS) cell lines with previously published allele level KIR genotypes and 176 Western Australian samples previously tested for the presence or absence of KIR genes. Our long\u2010read sequencing method was able to accurately determine KIR alleles with an overall concordance of 97%\u201399% with the published data. Importantly, phasing ambiguity caused by the inability to phase heterozygous base positions over long stretches of gene sequence was resolved in several samples. 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\u201cGenerating Full\u2010Length Killer\u2010Cell Immunoglobulin\u2010Like Receptor (Kir) Gene Sequences Using Third Generation Long\u2010Amplicon Sequencing to Assess the Impact of kir Polymorphism on Haematopoietic Cell Transplantation Outcomes \u201d ProQuest Dissertations & 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Urology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.juro.2014.02.1577","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T19:33:00Z","timestamp":1396035180000},"source":"Crossref","is-referenced-by-count":0,"title":["MP56-09 HIGH QUALITY RESECTION AT INITIAL TRANSURETHRAL RESECTION OF BLADDER TUMOR REDUCES THE LIKELIHOOD OF UPSTAGING AT RE-RESECTION: A CONTEMPORARY SERIES"],"prefix":"10.1097","volume":"191","author":[{"given":"Rasha","family":"Gendy","sequence":"first","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Patel","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warick","family":"Delprado","sequence":"additional","affiliation":[{"name":"Sydney, 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Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534714018357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534714018357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2014.02.1577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T04:15:55Z","timestamp":1651205755000},"score":7.594402,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2014.02.1577"}},"issued":{"date-parts":[[2014,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1016\/j.juro.2014.02.1577"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2014.02.1577","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2014,4]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:15Z","timestamp":1753889835349,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: In a large animal model of type 2 diabetes (T2D), we have shown that portal, GLP-1-dependent, glucose sensing is impaired and a low-dose dihydrotestosterone (DHT) implant inserted into the area of the portal sensor normalizes glucose metabolism acutely. We evaluated the capacity of portal DHT to achieve sustained remission of diabetes and its impact on cardiovascular and renal function.<\/jats:p>\n Methods: Three groups of six minipigs (aged 3yr) were used. In two groups, diabetes was induced (obesogenic diet plus streptozotocin 80 mg\/kg, IV). In half of these, a silicon implant delivering 100\u03bcg\/24H DHT was inserted laparoscopically in the region of the GLP-1r (DHT); the other half received a sham implant (Sham). The third group was fed a non-obesogenic diet (Lean). One year following implant insertion, daily glucose (CGM), fasting plasma insulin, insulin sensitivity (euglycemic hyperinsulinemic clamp), cardiovascular function (HF oscillometry, Doppler ultrasound, and gated 18 FDG PET) and glomerular filtration rate (68 Ga DOTA PET), were measured.<\/jats:p>\n Results: Data are presented in the table.<\/jats:p>\n \n Conclusion: In a large animal model of T2D, low-dose, portal DHT administration has sustained effects to improve both glycemic control and insulin sensitivity, and preserves cardiovascular and renal function.<\/jats:p>\n \n Disclosure<\/jats:title>\n C. Malbert: None. M.R. Allouche: None. M. Horowitz: None. K.L. Jones: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-2171-lb","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T07:07:59Z","timestamp":1749798479000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["2171-LB: A Low-Dose, Portal Dihydrotestosterone Implant Has a Sustained Effect to Improve Glycemic Control and Provides Cardiovascular and Renal Protection in a Large Animal Model of Type 2 Diabetes"],"prefix":"10.2337","volume":"74","author":[{"given":"CHARLES-HENRI","family":"MALBERT","sequence":"first","affiliation":[{"name":"Saint-Gilles, France, Paris, France, South Australia, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAURICE R.","family":"ALLOUCHE","sequence":"additional","affiliation":[{"name":"Saint-Gilles, France, Paris, France, South Australia, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL","family":"HOROWITZ","sequence":"additional","affiliation":[{"name":"Saint-Gilles, France, Paris, France, South Australia, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAREN L.","family":"JONES","sequence":"additional","affiliation":[{"name":"Saint-Gilles, France, Paris, France, South Australia, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/2171-LB\/160343\/2171-LB-A-Low-Dose-Portal-Dihydrotestosterone","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/2171-LB\/160343\/2171-LB-A-Low-Dose-Portal-Dihydrotestosterone","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T17:12:58Z","timestamp":1750439578000},"score":7.594316,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/2171-LB\/160343\/2171-LB-A-Low-Dose-Portal-Dihydrotestosterone"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-2171-lb","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"2171-LB"},{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T10:48:52Z","timestamp":1783248532183,"version":"3.54.6"},"reference-count":143,"publisher":"American Geophysical Union (AGU)","issue":"8","license":[{"start":{"date-parts":[[2018,8,19]],"date-time":"2018-08-19T00:00:00Z","timestamp":1534636800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["agupubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geochem Geophys Geosyst"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Abstract<\/jats:title>The role of lithospheric architecture and the mantle in the genesis of iron oxide copper\u2010gold (IOCG) deposits is controversial. Using the example of the Precambrian Gawler Craton (South Australia), which hosts the giant Olympic Dam IOCG deposit, we integrate geophysical data (seismic tomography and magnetotellurics) with geological and geochemical data to develop a new interpretation of the lithospheric setting of these deposits. Spatially, IOCG deposits are located above the margin of a mantle lithospheric zone with anomalously high electrical conductivities (resistivity <10\u00a0ohm.m, top at ~100\u2013150\u00a0km depth), low seismic shear\u2010wave velocities (horizontal component, Vsh\u00a0<\u00a04.6\u00a0km\/s), and unusually high ratios of compressional\u2010 to shear\u2010wave velocities (Vp\/Vsh\u00a0>\u00a01.80). The high conductivity cannot be explained by water\u2010bearing olivine\u2010rich rock alone. Relatively fertile and metasomatized peridotitic mantle with additional high\u2010Vp\/Vs phases, for example, clinohumite, hydrous garnet, and\/or phlogopite, could explain the anomalous velocity and conductivity. The top of this high\u2010Vp\/Vsh zone marks a midlithospheric discontinuity at ~100\u2013130\u00a0km depth that is interpreted to reflect locally orthopyroxene\u2010rich mantle. A sub\u2010Moho zone with high Vp\/Vsh at ~40\u201380\u00a0km depth correlates spatially with primitive Nd isotope signatures and arc\u2010related ~1,620\u20131,610\u00a0Ma magmatism and is interpreted as the eclogitic root of a magmatic arc. Mafic volcanics contemporaneous with ~1,590\u00a0Ma IOCG mineralization have geochemistry suggesting derivation from subduction\u2010modified lithospheric mantle. We suggest that Olympic Dam formed inboard of a continental margin in a postsubduction setting, related to foundering of previously refertilized and metasomatized lithospheric mantle. Deposits formed during the switch from compression to extension, following delamination\u2010related uplift and exhumation.<\/jats:p>","DOI":"10.1029\/2018gc007561","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T13:24:26Z","timestamp":1532611466000},"page":"2673-2705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Lithospheric Architecture and Mantle Metasomatism Linked to Iron Oxide Cu\u2010Au Ore Formation: Multidisciplinary Evidence from the Olympic Dam Region, South Australia"],"prefix":"10.1029","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9684-1554","authenticated-orcid":false,"given":"R. G.","family":"Skirrow","sequence":"first","affiliation":[{"name":"Geoscience Australia Canberra ACT Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2597-2055","authenticated-orcid":false,"given":"S. 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The role of external researchers in data quality assessment (DQA) remains ill-defined in the context of secondary use for research of large, centrally curated health datasets. In order to investigate equity of palliative care provided to Indigenous Australian patients, researchers accessed a now-historical version of a national palliative care dataset developed primarily for the purpose of continuous quality improvement.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n (i) To apply a generic DQA framework to the dataset and (ii) to report the process and results of this assessment and examine the consequences for conducting the research.<\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n The data were systematically examined for completeness, consistency and credibility. Data quality issues relevant to the Indigenous identifier and framing of research questions were of particular interest.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The dataset comprised 477,518 records of 144,951 patients (Indigenous N = 1515; missing Indigenous identifier N = 4998) collected from participating specialist palliative care services during a period (1 January 2010\u201330 June 2015) in which data-checking systems underwent substantial upgrades. Progressive improvement in completeness of data over the study period was evident. The data were error-free with respect to many credibility and consistency checks, with anomalies detected reported to data managers. 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The residual approach to measuring cognitive reserve (i.e., using the residual reserve index) aims to capture cognitive resilience, but may be confounded by unmeasured brain factors representing brain resilience. We sought to distinguish between brain and cognitive resilience by comparing the interactions between the residual reserve index and amyloid, tau, and neurodegeneration (AT(N); Jack et al., 2018) biomarkers when predicting executive function. We hypothesized that the residual reserve index would moderate at least one path from an AT(N) biomarker to executive function (consistent with cognitive resilience), as opposed to moderating a path between two AT(N) biomarkers (suggestive of brain resilience).<\/jats:p><\/jats:sec>Method<\/jats:title>Participants were 332 older adults from the Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI). AT(N) biomarkers were measured as follows: amyloid\u00a0=\u00a0CSF A\u03b242<\/jats:sub>\/A\u03b240<\/jats:sub>; tau\u00a0=\u00a0plasma p\u2010tau181; neurodegeneration\u00a0=\u00a0FDG metabolism in AD\u2010specific regions. AT(N) biomarkers were measured at consecutive time points and entered in a sequential mediation model testing the indirect effects from amyloid to executive function intercept and slope, via tau and\/or FDG metabolism. The residual reserve index was entered as a moderator of paths between AT(N) biomarkers, and between AT(N) biomarkers and executive function.<\/jats:p><\/jats:sec>Result<\/jats:title>The only significant interaction was between the residual reserve index and amyloid when predicting FDG metabolism, such that the indirect effect of amyloid \u2192 FDG metabolism \u2192 executive function intercept and slope varied as a function of the residual reserve index. With lower amyloid pathology, a higher residual reserve index predicted better executive function via lower FDG metabolism. With higher amyloid pathology, a higher residual reserve index predicted better executive function via higher FDG metabolism.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Although the residual reserve index moderated a path between two AT(N) biomarkers, the net effect was consistent with cognitive rather than brain resilience. 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Unhealthy dietary patterns across the life cycle are associated with an increased risk of chronic disease. Foodbank WA\u2019s Healthy Food for All<\/jats:italic>\u00ae<\/jats:sup> (HFFA) team has made addressing health inequity a priority, by enhancing food literacy skills of vulnerable people across the lifespan.<\/jats:p><\/jats:sec>Methods<\/jats:title>A case study approach was utilised to explore HFFA\u2019s suite of evidence\u2010based food literacy programs: Food Sensations<\/jats:italic>\u00ae<\/jats:sup> (FS) for Parents (of 0\u20105\u00a0year olds), FS for Schools (kindergarten to Year 12), Fuel Your Future (adolescents 12\u201018\u00a0years), and FS for Adults (FSA) (18\u00a0years and over). These programs are contextualised to meet the needs of vulnerable groups at all life stages.<\/jats:p><\/jats:sec>Results<\/jats:title>In the last decade the HFFA team have delivered 5047 food literacy sessions to over 62\u00a0000 vulnerable Western Australians. Evaluation results demonstrate the FS programs are successful at improving vulnerable people's food literacy skills and dietary behaviours. For example, over 70% of participants make at least one positive food behaviour change after attending FSA.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>By targeting vulnerable people of all ages, HFFA\u2019s food literacy programs provide multiple opportunities for intervention, to enhance health behaviours, and therefore reduce risk of chronic disease.<\/jats:p><\/jats:sec>So What?<\/jats:title>Food literacy programs are one effective strategy that is complementary in helping to address the health inequities in Australia. Government and broader community investment in food literacy initiatives is vital to improving the health outcomes of vulnerable populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hpja.414","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T10:44:56Z","timestamp":1599216296000},"page":"5-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Can addressing food literacy across the life cycle improve the health of vulnerable populations? 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Ethical concerns and debates surrounding the treatment, such as eligibility and accessibility, are ongoing in Australia. The Australian Bragg Centre for Proton Therapy and Research (ABCPTR) (named after Sir William Henry Bragg who described the Bragg peak in his laboratory at the University of Adelaide in 1903) aims to increase access to PBT in Australasia and offer a patient\u2010centred care approach. Research is underway to assess PBT's safety and cost\u2010effectiveness, using tools including Normal Tissue Complication Probability (NTCP) models. Collaborative efforts are focused on developing tailored survivorship clinics to enhance patient follow\u2010up and quality of life. With the anticipated opening of the ABCPTR, Australia is preparing to take a significant step in radiation oncology, offering new research opportunities and creating a publicly funded treatment centre. The initiative aims to balance treatment efficacy with patient care, setting the stage for a future in which radiation therapy will reduce long\u2010term side effects compared to the current standard of care. The implementation of PBT in Australia represents a complex and promising approach to paediatric oncology. 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However, the pharmacokinetic effects of pregnancy on thiopurine metabolism are undefined.<\/jats:p><\/jats:sec>Aims<\/jats:title>To characterise thiopurine metabolism in pregnancy and measure infant metabolite levels and outcomes.<\/jats:p><\/jats:sec>Methods<\/jats:title>Women with IBD who were taking a thiopurine and pregnant or trying to conceive were recruited. Maternal thiopurine metabolites were measured pre\u2010conception, in each trimester, at delivery and post\u2010partum. Infant metabolite levels, full blood examination and liver function testing were performed at birth, and repeated until levels undetectable and haematological and biochemical abnormalities resolved.<\/jats:p><\/jats:sec>Results<\/jats:title>Forty patients were included with measurements on at least two occasions, and two with only mother\u2010baby levels at delivery. The median maternal 6\u2010TGN level dropped in the second trimester compared with post\u2010partum (179.0 vs 323.5\u00a0pmol\/8\u00a0\u00d7\u00a0108<\/jats:sup> RBCs, P<\/jats:italic>\u00a0<\u00a00.001) and the median 6\u2010MMP level increased in the second trimester compared with post\u2010partum (1103.0 vs 329.5\u00a0pmol\/8\u00a0\u00d7\u00a0108<\/jats:sup> RBCs, P<\/jats:italic>\u00a0<\u00a00.01). At delivery, the median 6\u2010TGN level was lower in infants (n\u00a0=\u00a020) than mothers (78.5 vs 217\u00a0pmol\/8\u00a0\u00d7\u00a0108<\/jats:sup> RBCs) (P<\/jats:italic>\u00a0<\u00a00.001). Metabolites were not detected at 6\u00a0weeks in any infants. Anaemia was not seen, but thrombocytosis and abnormal liver biochemistry were detected in 80% of infants from 6\u00a0weeks, which gradually improved.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>6\u2010TGN levels decrease and 6\u2010MMP levels increase in the second trimester of pregnancy. Infants are exposed to thiopurine metabolites at low levels with clearance by 6\u00a0weeks and no anaemia. The cause of infant thrombocytosis and abnormal liver biochemistry in the absence of metabolites is unclear.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16294","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T06:30:15Z","timestamp":1693549815000},"page":"810-820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Maternal thiopurine metabolism during pregnancy in inflammatory bowel disease and clearance of thiopurine metabolites and outcomes in exposed neonates"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3911-4780","authenticated-orcid":false,"given":"Emma","family":"Flanagan","sequence":"first","affiliation":[{"name":"Melbourne Vic. 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[Online]. Retrieved September 21, 2025, from https:\/\/openjournals.library.sydney.edu.au\/SWPS\/article\/view\/20472#:~:text=The%20delivery%20and%20evaluation%20of%20%E2%80%98The%20Truth%20of,recruited%20from%20out-of-home%20care%20staff%20and%20foster%20carers","journal-title":"Social Work & Policy Studies: Social Justice, Practice and Theory"},{"key":"e_1_3_3_41_1","first-page":"60","article-title":"Curbing mission creep","volume":"6","author":"Jonker K.","year":"2008","unstructured":"Jonker K., Meehan F. W.III (2008). Curbing mission creep. Stanford Social Innovation Review, 6, 60\u201365. https:\/\/doi.org\/10.48558\/75be-ma15","journal-title":"Stanford Social Innovation Review"},{"key":"e_1_3_3_42_1","unstructured":"Key Assets Australia. (n.d). Key Assets: Purposes and Pledges [Online]. 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Consequently, delayed management may affect the quality of life and the growth and development of a child. Due to their patient demographic, orthodontists are optimally positioned to identify those at risk of sleep\u2010disordered breathing and make referrals for investigation and management. This study aims to determine the prevalence of children at risk of sleep\u2010disordered breathing in an Australian orthodontic population.<\/jats:p><\/jats:sec>Methods<\/jats:title>A 1\u2010year retrospective study was conducted in an urban Western Australian private orthodontic practice with two branches in similar socioeconomic demographics. The responses of new patients to a modified paediatric sleep questionnaire and standard medical history form were recorded.<\/jats:p><\/jats:sec>Results<\/jats:title>In 1209 patients (4\u201318\u2009years), 7.3% were at risk of sleep\u2010disordered breathing. An association between sex and the potential risk of sleep\u2010disordered breathing was found with 11% of males at risk of sleep\u2010disordered breathing compared to 7% of females (P<\/jats:italic>\u00a0=\u20090.012).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The relatively high prevalence of children at risk of sleep\u2010disordered breathing presenting for orthodontic care presents an opportunity to identify at\u2010risk individuals through routine use of the paediatric sleep questionnaire. This would facilitate early referral for diagnosis and management of sleep\u2010disordered breathing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/adj.12945","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T13:10:11Z","timestamp":1667913011000},"page":"26-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sleep\u2010disordered breathing in children seeking orthodontic care\u2014an Australian perspective"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4358-1760","authenticated-orcid":false,"given":"A","family":"Wellham","sequence":"first","affiliation":[{"name":"Dental School The University of Western Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Kim","sequence":"additional","affiliation":[{"name":"Dental School The University of Western Australia Nedlands Western 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To our knowledge, this project is the first to apply a realist research approach to conducting a needs assessment. We conducted and analysed realist informed teacher-learner cycle interviews with rural healthcare professionals to inform our program theory. In these interviews, we presented participants with a summary of guideline recommendations for the assessment and management of chronic pain. We asked participants which recommendations they found easy and challenging to implement in their local setting, and discussed why, how, and in what circumstances this was the case. We detail how we analysed interview transcripts retroductively in NVivo and how the authorship team abstracted from the clinical scenarios provided by interviewees to generate theories at a \u2018middle level\u2019 of abstraction. Our discussion details lessons learned from the utilised methods with recommendations for how we would adapt these methods in the future.<\/jats:p>","DOI":"10.1177\/16094069241310276","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T04:19:11Z","timestamp":1736223551000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Realist Needs Assessment Investigating the Factors Affecting Implementation of Guideline-Based Care for Chronic Pain in Rural Australia: Program Theory Generation"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6071-8979","authenticated-orcid":false,"given":"Ashley R","family":"Grant","sequence":"first","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gill","family":"Westhorp","sequence":"additional","affiliation":[{"name":"Charles Darwin University Northern Institute, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Mardon","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"},{"name":"Western Sydney University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L","family":"Karran","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D","family":"Hibbert","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"},{"name":"Macquarie University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Roeger","sequence":"additional","affiliation":[{"name":"Tumby Bay Medical, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Lorimer","family":"Moseley","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"bibr1-16094069241310276","author":"Australian Commission on Safety and Quality in Health Care","year":"2022","journal-title":"Clinical Care Standards, Issue. Australian Commission on Safety and Quality in Health Care"},{"key":"bibr2-16094069241310276","unstructured":"Bennet C. (2020). RE: NICE chronic pain assessment and management guidelines. https:\/\/www.painaustralia.org.au\/static\/uploads\/files\/nice-chronic-pain-guidelines-submission-from-painaustralia-online-wfpupecnfluz.pdf"},{"key":"bibr3-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15379"},{"key":"bibr4-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-59403-9_27"},{"key":"bibr5-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1177\/014107680710001012"},{"key":"bibr6-16094069241310276","volume-title":"Consumer involvement in cochrane - the Statement of principles cochrane","author":"Cochrane","year":"2017"},{"key":"bibr7-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-040961"},{"key":"bibr8-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1177\/1077558720975543"},{"key":"bibr9-16094069241310276","volume-title":"Statement on consumer and community involvement in health and medical research","author":"Consumers Health Forum of Australia (CHF), & National Health and Medical Research Council (NHMRC)","year":"2016"},{"key":"bibr10-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1080\/13645579.2020.1803528"},{"key":"bibr11-16094069241310276","unstructured":"Deloitte Access Economics. (2019). The cost of pain in Australia."},{"key":"bibr12-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1177\/1098214015605175"},{"key":"bibr13-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001978"},{"key":"bibr14-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-016-2244-7"},{"key":"bibr15-16094069241310276","author":"Exercise and Sports Science Australia (ESSA)","year":"2021","journal-title":"ESSA"},{"key":"bibr16-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1177\/1609406919859754"},{"key":"bibr17-16094069241310276","author":"Grant A. R.","year":"2024","journal-title":"Manuscript submitted for publication"},{"key":"bibr18-16094069241310276","volume-title":"Increasing access to pain care services to improve rural pain management: A realist review investigating factors affecting uptake, implementation, and sustainability","author":"Grant A. R.","year":"2024"},{"key":"bibr19-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22891"},{"key":"bibr20-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12195"},{"key":"bibr21-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1016\/j.pecinn.2023.100175"},{"key":"bibr22-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.4.436"},{"issue":"21","key":"bibr23-16094069241310276","first-page":"S27","volume":"213","author":"Lieschke G.","year":"2020","journal-title":"Medical Journal of Australia"},{"key":"bibr24-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2018-099878"},{"key":"bibr25-16094069241310276","unstructured":"Lumivero. (2020). NVivo 14. https:\/\/www.lumivero.com\/"},{"key":"bibr26-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1177\/1356389016638615"},{"key":"bibr27-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1177\/1356389012442444"},{"key":"bibr28-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4301"},{"key":"bibr29-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002217"},{"key":"bibr30-16094069241310276","volume-title":"Chronic pain (primary and secondary) in over 16s: Assessment of all chronic pain and management of chronic primary pain","author":"NICE guideline [NG193]","year":"2021"},{"key":"bibr31-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1258\/1355819054308530"},{"key":"bibr32-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1177\/1356389012440912"},{"key":"bibr33-16094069241310276","volume-title":"Realistic evaluation","author":"Pawson R.","year":"1997"},{"key":"bibr34-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1800.2011.00551.x"},{"key":"bibr35-16094069241310276","unstructured":"Qualtrics. (2020). Qualtrics. https:\/\/www.qualtrics.com"},{"key":"bibr36-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1186\/1748-5908-7-33"},{"key":"bibr37-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000324"},{"key":"bibr38-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1002\/9781118826164"},{"key":"bibr39-16094069241310276","doi-asserted-by":"publisher","DOI":"10.4324\/9780429287510"},{"key":"bibr40-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236419"},{"key":"bibr41-16094069241310276","unstructured":"The RAMESES II Project. (2017). Retroduction in realist evaluation. https:\/\/www.ramesesproject.org\/media\/RAMESES_II_Retroduction.pdf"},{"key":"bibr42-16094069241310276","unstructured":"Therapeutic Guidelines. (2020). Pain and analgesia. https:\/\/www.tg.org.au"},{"key":"bibr43-16094069241310276","volume-title":"Evidence synthesis for health policy and systems: A methods guide","author":"Wong G.","year":"2018"},{"key":"bibr44-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-21"},{"key":"bibr45-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0643-1"},{"key":"bibr46-16094069241310276","volume-title":"Realist synthesis - RAMESES training materials","author":"Wong G.","year":"2013"},{"key":"bibr47-16094069241310276","volume-title":"WHO global strategy on people-centred and integrated health services: Interim report","author":"World Health O.","year":"2015"},{"key":"bibr48-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e3182a51b3d"},{"key":"bibr49-16094069241310276","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-032329"}],"container-title":["International Journal of Qualitative Methods"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/16094069241310276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/16094069241310276","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/16094069241310276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:11:20Z","timestamp":1777457480000},"score":7.592408,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/16094069241310276"}},"issued":{"date-parts":[[2025,1,7]]},"references-count":49,"alternative-id":["10.1177\/16094069241310276"],"URL":"https:\/\/doi.org\/10.1177\/16094069241310276","ISSN":["1609-4069","1609-4069"],"issn-type":[{"value":"1609-4069","type":"print"},{"value":"1609-4069","type":"electronic"}],"published":{"date-parts":[[2025,1,7]]},"article-number":"16094069241310276"},{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:10:20Z","timestamp":1760299820388,"version":"3.37.3"},"reference-count":6,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>There is controversy on the optimal work\u2010up of screen\u2010detected widespread breast calcifications: whether to biopsy a single target or multiple targets. This study evaluates agreement between multiple biopsy targets within the same screen\u2010detected widespread (\u226525\u00a0mm) breast calcification to determine if the second biopsy adds value.<\/jats:p><\/jats:sec>Methods<\/jats:title>Retrospective observational study of women screened in a statewide general population risk breast cancer mammographic screening program from 2009 to 2016. Screening episodes recalled for widespread calcifications where further views indicated biopsy, and two or more separate target areas were sampled within the same lesion were included. Percentage agreement and Cohen's Kappa were calculated.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 293317 women were screened during 761124 separate episodes with recalls for widespread calcifications in 2355 episodes. In 171 women, a second target was biopsied within the same lesion. In 149 (86%) cases, the second target biopsy result agreed with the first biopsy (\u03ba\u00a0=\u00a00.6768). Agreement increased with increasing mammography score (85%, 86% and 92% for score 3, 4 and 5 lesions). Same day multiple biopsied lesions were three times more likely to yield concordant results compared to post\u2010hoc second target biopsy cases.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>While a single target biopsy is sufficient to discriminate a benign vs. malignant diagnosis in most cases, in 14% there is added value in performing a second target biopsy. Biopsies performed prospectively are more likely to yield concordant results compared to post\u2010hoc second target biopsy cases, suggesting a single prospective biopsy may be sufficient when results are radiological\u2010pathological concordant; discordance still requires repeat sampling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.12715","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T06:02:07Z","timestamp":1519365727000},"page":"299-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Added value of second biopsy target in screen\u2010detected widespread suspicious breast calcifications"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2528-3567","authenticated-orcid":false,"given":"Nathalie M","family":"Falkner","sequence":"first","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Hince","sequence":"additional","affiliation":[{"name":"Notre Dame University Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Nedlands Western Australia Australia"},{"name":"BreastScreenWA Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Dessauvagie","sequence":"additional","affiliation":[{"name":"Anatomical Pathology PathWest Laboratory Medicine WA Perth Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"School of Pathology and Laboratory Medicine University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Jeganathan","sequence":"additional","affiliation":[{"name":"BreastScreenWA Perth Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Perth Radiological Clinic Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Bulsara","sequence":"additional","affiliation":[{"name":"Notre Dame University Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6906-588X","authenticated-orcid":false,"given":"Glen","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Nedlands Western Australia Australia"},{"name":"BreastScreenWA Perth Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Western Ultrasound for Women Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"volume-title":"ACR BI\u2010RADS\u00ae Atlas, Breast Imaging Reporting and Data System","year":"2013","author":"Sickles EA","key":"e_1_2_6_2_1"},{"key":"e_1_2_6_3_1","unstructured":"ZorbasH AhernV BilousMet\u00a0al.Synoptic Breast Imaging Report.2007. Available from URL:http:\/\/www.worldcat.org\/title\/recommendations-for-a-synoptic-breast-imaging-report-including-imaging-classification-system\/oclc\/225576222"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2015.12.025"},{"key":"e_1_2_6_5_1","unstructured":"ReeveT BandaranayakeR BarracloughBet\u00a0al.National Health and Medical Research Council. National Breast Cancer Centre: Clinical Practice Guidelines for the Management of Early Breast Cancer [Internet].2001. Available from URL:https:\/\/canceraustralia.gov.au\/system\/tdf\/publications\/cpg-clinical-practice-guidelines-management-early-breast-cancer_504af03111a52.pdf?file=1&type=node&id=2941"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2011.14.1.1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2010.01.008"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1754-9485.12715","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.12715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:48:48Z","timestamp":1695473328000},"score":7.5922594,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.12715"}},"issued":{"date-parts":[[2018,2,22]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/1754-9485.12715"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.12715","archive":["Portico"],"ISSN":["1754-9477","1754-9485"],"issn-type":[{"type":"print","value":"1754-9477"},{"type":"electronic","value":"1754-9485"}],"published":{"date-parts":[[2018,2,22]]},"assertion":[{"value":"2017-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:04:32Z","timestamp":1774379072977,"version":"3.50.1"},"reference-count":8,"publisher":"IEEE","license":[{"start":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T00:00:00Z","timestamp":1658016000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T00:00:00Z","timestamp":1658016000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2022,7,17]]},"DOI":"10.1109\/igarss46834.2022.9883977","type":"proceedings-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T20:12:24Z","timestamp":1664395944000},"page":"7775-7778","source":"Crossref","is-referenced-by-count":1,"title":["Validating Landsat and Sentinel-2 Analysis Ready Data with Uav-Mounted Spectrometers"],"prefix":"10.1109","author":[{"given":"Mark","family":"Broomhall","sequence":"first","affiliation":[{"name":"Digital Earth Australia, Geoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Byrne","sequence":"additional","affiliation":[{"name":"Digital Earth Australia, Geoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Hay","sequence":"additional","affiliation":[{"name":"Digital Earth Australia, Geoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Medhavy","family":"Thankappan","sequence":"additional","affiliation":[{"name":"Digital Earth Australia, Geoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Walsh","sequence":"additional","affiliation":[{"name":"Digital Earth Australia, Geoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rse.2007.08.001"},{"key":"ref2","article-title":"DEA Analysis Ready Data Phase 1 Validation Project: Data Summary","author":"Byrne","year":"2021","journal-title":"Geoscience Australia"},{"key":"ref3","article-title":"A community appraoch to the standardisation of surface reflectance data. A technical handbook to support the collection of field reflectance data","volume-title":"CSIRO","author":"Malthus","year":"2018"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1109\/JSTARS.2010.2042281"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rse.2012.06.018"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/rs70100725"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.rse.2016.01.023"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.rse.2017.06.019"}],"event":{"name":"IGARSS 2022 - 2022 IEEE International Geoscience and Remote Sensing Symposium","location":"Kuala Lumpur, Malaysia","start":{"date-parts":[[2022,7,17]]},"end":{"date-parts":[[2022,7,22]]}},"container-title":["IGARSS 2022 - 2022 IEEE International Geoscience and Remote Sensing Symposium"],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/9883023\/9883024\/09883977.pdf?arnumber=9883977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T06:26:58Z","timestamp":1726036018000},"score":7.591922,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/9883977\/"}},"issued":{"date-parts":[[2022,7,17]]},"references-count":8,"URL":"https:\/\/doi.org\/10.1109\/igarss46834.2022.9883977","published":{"date-parts":[[2022,7,17]]}},{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:24:21Z","timestamp":1787246661296,"version":"build-2736575974"},"reference-count":0,"publisher":"Society of Exploration Geophysicists","content-domain":{"domain":[],"crossmark-restriction":false},"abstract":"The Ceduna Sub-basin is a large, underexplored sub-basin on the continental margin of southern Australia in the Great Australian Bight. Recent acreage releases in the basin have resulted in renewed exploration interest. Murphy and Santos were jointly awarded the EPP43 acreage on the western margin of the basin in 2013 and PGS have subsequently acquired broadband 3D seismic across EPP43. A large delta system formed in the Ceduna Sub-basin during the Early\u2013Late Cretaceous, depositing over 10km thickness of sediments. Detailed seismic stratigraphy has illustrated a series of major transgressions and regressions across the delta. Consequent variation in the amount of sediment input has effected the local sediment loading patterns, hence effecting the fault patterns. Distinct sets of listric faults exist vertically, and show varying character from proximal to distal. Structurally, the Ceduna Sub-basin is unusual in Australia, with faulting being sediment load driven (listric), rather than tectonically derived. Syn-sedimentary listric faulting is pervasive throughout the Cenomanian and Turonian deltaic section. The faults rotate with depth and often detach into a mobile stratigraphy, usually ductile shales. Down dip the listric faults feed mobile thrust belts at the toe of the delta system. Few external forces affect the orientation of faults, and the delta system forms using gravity sliding and gravity spreading in an arcuate form. Underlying the decollement surface is a Jurassic rift system formed by the separation of Australia from Antarctica commencing in the Middle Jurassic. These rift-related faults show very different orientations (mostly east-west) in comparison to the listric faults. The interaction of the Jurassic faults with the overlying Cretaceous delta system appear limited, suggesting that the initial rift has seen little tectonic activity since its initiation. Eocene volcanics have been documented in the east of the Ceduna Sub-basin. The PGS Springboard 3D seismic data has shown that similar volcanics are also present in the west of the sub-basin. Cinder cones are often located above the tip of listric faults showing that the faults are clearly acting as weaknesses that have been exploited by the volcanics rising through the thick sediment package.<\/jats:p>","DOI":"10.1190\/ice2015-2209058","type":"proceedings-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T14:10:38Z","timestamp":1458223838000},"page":"402-402","source":"Crossref","is-referenced-by-count":0,"title":["Structural Architecture of the Ceduna Sub-Basin: The Effects of Older Fault Orientations, and More Recent Exploitation of Weaknesses"],"prefix":"10.1190","volume":"1","author":[{"given":"Helena","family":"Griffiths","sequence":"additional","affiliation":[{"name":"(1) Murphy Australia Oil, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Horton*","sequence":"additional","affiliation":[{"name":"(1) Murphy Australia Oil, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Nettle","sequence":"additional","affiliation":[{"name":"(2) Santos, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dushyan","family":"Rajeswaran","sequence":"additional","affiliation":[{"name":"(3) PGS Multiclient Services, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren D.","family":"Ferdinando","sequence":"additional","affiliation":[{"name":"(1) Murphy Australia Oil, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"186","published-online":{"date-parts":[[2015,9,16]]},"event":{"name":"International Conference and Exhibition, Melbourne, Australia 13-16 September 2015","location":"Melbourne, Australia","acronym":"icemelbourne2015","start":{"date-parts":[[2015,9,13]]},"end":{"date-parts":[[2015,9,16]]}},"container-title":["Global Meeting Abstracts","International Conference and Exhibition, Melbourne, Australia 13-16 September 2015"],"link":[{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/402\/713642","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/402\/713642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:27:19Z","timestamp":1787243239000},"score":7.5918937,"resource":{"primary":{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/402\/713642"}},"issued":{"date-parts":[[2015,9,16]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1190\/ice2015-2209058","ISSN":["2159-6832"],"issn-type":[{"value":"2159-6832","type":"electronic"}],"published":{"date-parts":[[2015,9,16]]}},{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:28:01Z","timestamp":1777915681643,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2018,7]]},"abstract":"\n Background:<\/jats:title>\n The isolated heart apparatus is over 100 years old, but remains a useful research tool today. While designs of many large animal systems have been described in the literature, trouble-shooting and refining such a model to yield a stable, workable system has not been previously described. This paper outlines the issues, in tabular form, that our group encountered in developing our own porcine isolated heart rig with the aim of assisting other workers in the field planning similar work. The paper also highlights some of the modern applications of the isolated heart apparatus.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Landrace pigs (50-80 kg) were used in a pilot project to develop the model. The model was then used in a study examining the effects of various cardioplegic solutions on function after reanimation of porcine hearts. During the two projects, non-protocol issues were documented as well as their solutions. These were aggregated in this paper.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Issues faced by the group without explicit literature solutions included pig size selection, animal acclimatisation, porcine transoesophageal echocardiography, cannulation and phlebotomy for cross-clamping, cardioplegia delivery, heart suspension and rig tuning.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Prior recognition of issues and possible solutions faced by workers establishing a porcine isolated heart system will speed progress towards a useable system for research. The isolated heart apparatus remains applicable in transplant, ischaemia reperfusion, heart failure and organ preservation research.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/0267659117746232","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T17:34:51Z","timestamp":1514050491000},"page":"363-366","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The practicalities of establishing a porcine isolated heart model"],"prefix":"10.1177","volume":"33","author":[{"given":"Warren","family":"Pavey","sequence":"first","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthea","family":"Raisis","sequence":"additional","affiliation":[{"name":"Murdoch University School of Veterinary and Life Sciences, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Dunne","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Els","family":"Van Laeken","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Jenkinson","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viji","family":"Vincent","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Baird","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"bibr1-0267659117746232","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2006.05.006"},{"key":"bibr2-0267659117746232","doi-asserted-by":"publisher","DOI":"10.1097\/PAF.0b013e31823d298b"},{"key":"bibr3-0267659117746232","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivv381"},{"key":"bibr4-0267659117746232","doi-asserted-by":"publisher","DOI":"10.1016\/S1522-2942(07)70108-3"},{"key":"bibr5-0267659117746232","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-008-0359-2"},{"key":"bibr6-0267659117746232","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000791"},{"key":"bibr7-0267659117746232","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2015.01.005"},{"key":"bibr8-0267659117746232","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-006-0584-5"},{"key":"bibr9-0267659117746232","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12782"},{"key":"bibr10-0267659117746232","doi-asserted-by":"publisher","DOI":"10.1007\/s12170-011-0184-2"},{"key":"bibr11-0267659117746232","doi-asserted-by":"publisher","DOI":"10.3791\/2069."},{"key":"bibr12-0267659117746232","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00282.2015"}],"container-title":["Perfusion"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0267659117746232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0267659117746232","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0267659117746232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:27:00Z","timestamp":1777656420000},"score":7.5918584,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0267659117746232"}},"issued":{"date-parts":[[2017,12,22]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1177\/0267659117746232"],"URL":"https:\/\/doi.org\/10.1177\/0267659117746232","ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"published":{"date-parts":[[2017,12,22]]}},{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T10:42:23Z","timestamp":1694601743195},"reference-count":0,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1111\/imj.1_13457","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T10:08:51Z","timestamp":1494238131000},"page":"7-7","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["RACP TRAINEE AWARDS FOR EXCELLENCE IN THE FIELD OF ADULT MEDICINE"],"prefix":"10.1111","volume":"47","author":[{"given":"K","family":"Goldsmith","sequence":"first","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Balabanski","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Giarola","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Buxton","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Castle","sequence":"additional","affiliation":[{"name":"Wardliparingga, SA Health and Medical Research Institute Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"McBride","sequence":"additional","affiliation":[{"name":"Wardliparingga, SA Health and Medical Research Institute Adelaide South Australia Australia"},{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Brady","sequence":"additional","affiliation":[{"name":"Alice Springs Hospital Alice Springs Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Burrow","sequence":"additional","affiliation":[{"name":"Royal Darwin Hospital Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AG","family":"Thrift","sequence":"additional","affiliation":[{"name":"Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Koblar","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Brown","sequence":"additional","affiliation":[{"name":"Wardliparingga, SA Health and Medical Research Institute Adelaide South Australia Australia"},{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kleinig","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,8]]},"container-title":["Internal Medicine Journal"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.1_13457","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.1_13457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T21:42:57Z","timestamp":1694554977000},"score":7.5912867,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.1_13457"}},"issued":{"date-parts":[[2017,5]]},"references-count":0,"journal-issue":{"issue":"S3","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/imj.1_13457"],"URL":"https:\/\/doi.org\/10.1111\/imj.1_13457","archive":["Portico"],"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"2017-05-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T02:27:16Z","timestamp":1779416836967,"version":"3.53.1"},"reference-count":0,"publisher":"Clinical Exercise Physiology Association","issue":"s2","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2026,4]]},"abstract":"\n BACKGROUND:<\/jats:title>\n Adult Adolescent Idiopathic Scoliosis (AIS) involves post-skeletal maturity scoliosis that persists or progresses, characterized by postural imbalance, pain and functional limitations. Management often emphasizes non-operative strategies like Physiotherapeutic Scoliosis-Specific Exercises (PSSE), such as the structured ScoliBalance\u00ae program, to optimize postural control, coordination, and stability through active self-correction and targeted training. The Cobb angle remains the gold standard for quantifying and monitoring scoliotic curvature.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVE:<\/jats:title>\n To investigate the effect of the ScoliBalance\u00ae program as the sole intervention on Cobb angle in adults with idiopathic scoliosis, providing further evidence for its role in the non-surgical management of adult AIS.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n A consecutive cohort of sixteen adults diagnosed with adolescent idiopathic scoliosis (12 females) was evaluated. The mean age at commencement of treatment was 31.8 \u00b1 13.2 years. Participants presented with a mean baseline Cobb angle of 36.8 \u00b1 11.9\u00b0. All participants were treated using a novel ScoliBalance\u00ae PSSE as the sole intervention. The individualized ScoliBalance\u00ae program was based on PSSE principles and focused on achieving a specific three-dimensional postural correction according to each patient\u2019s curve type, followed by strengthening and stabilization of the corrected posture using exercises adapted from established PSSE schools. Treatment was delivered through one-hour, one-on-one clinical sessions with a trained ScoliBalance\u00ae provider, typically scheduled at regular intervals. Participants were prescribed a daily home exercise program. The mean duration of treatment was 44.8 \u00b1 18.5 months.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n Following treatment with ScoliBalance\u00ae as a standalone intervention, changes in Cobb angle were observed across the cohort. There was a statistically significant mean decrease in Cobb angle of -2.5 \u00b1 3.9\u00b0 (t(15) = 2.39, p = 0.015) with a medium effect size (Cohen\u2019s d = 0.60). Using a threshold of \u2265 5\u00b0 to define meaningful change, 4 of 16 participants demonstrated curve reduction (25%) and the remaining 12 participants demonstrated curve stabilization (75%). No participant experienced curve progression. No adverse events related to the intervention were reported; the program was well tolerated.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n ScoliBalance\u00ae PSSE, as a sole intervention in adults with idiopathic scoliosis, demonstrated improvement or stabilization in Cobb angle. These preliminary findings support the clinical feasibility and application of the ScoliBalance\u00ae PSSE protocol as a viable treatment option for the non-surgical management of adults with AIS. Further prospective studies with larger sample sizes are warranted to better define the long-term impact of ScoliBalance\u00ae PSSE on curve behavior, functional outcomes and quality of life in adult scoliosis populations.<\/jats:p>\n <\/jats:sec>","DOI":"10.31189\/2165-7629-15-s2.255","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:59:20Z","timestamp":1777341560000},"page":"255","source":"Crossref","is-referenced-by-count":0,"title":["SCOLIBALANCE\u00ae PHYSIOTHERAPEUTIC SCOLIOSIS-SPECIFIC EXERCISE PROTOCOL FOR ADULTS: A CASE SERIES ASSESSING THE FEASIBILITY AND EFFECTS ON COBB ANGLE"],"prefix":"10.31189","volume":"15","author":[{"given":"Rosemary","family":"Mirenzi","sequence":"first","affiliation":[{"name":"ScoliCare Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora -Lee","family":"Doueihi","sequence":"additional","affiliation":[{"name":"ScoliCare Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Oakley","sequence":"additional","affiliation":[{"name":"ScoliCare Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeb","family":"McAviney","sequence":"additional","affiliation":[{"name":"ScoliCare Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16145","container-title":["Journal of Clinical Exercise Physiology"],"link":[{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/15\/s2\/article-p255-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/15\/s2\/article-p255-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/15\/s2\/article-p255-s.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T01:51:54Z","timestamp":1779414714000},"score":7.591171,"resource":{"primary":{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/15\/s2\/article-p255-s.xml"}},"issued":{"date-parts":[[2026,4]]},"references-count":0,"journal-issue":{"issue":"s2"},"URL":"https:\/\/doi.org\/10.31189\/2165-7629-15-s2.255","ISSN":["2165-7629","2165-6193"],"issn-type":[{"value":"2165-7629","type":"electronic"},{"value":"2165-6193","type":"print"}],"published":{"date-parts":[[2026,4]]}},{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:46:25Z","timestamp":1787874385791,"version":"build-2784847793"},"reference-count":56,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"8","funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["ID0ENCAI9886"],"award-info":[{"award-number":["ID0ENCAI9886"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT110100201"],"award-info":[{"award-number":["FT110100201"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Western Australia Marine Science Institution","award":["ID0EHHAI9887"],"award-info":[{"award-number":["ID0EHHAI9887"]}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["ID0E4LAI9888"],"award-info":[{"award-number":["ID0E4LAI9888"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["CE140100020"],"award-info":[{"award-number":["CE140100020"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2016,8,5]]},"abstract":"Tidal and solar cycles interact to regulate temperature extremes in tide-dominated reefs and will be reduced with sea level rise.<\/jats:p>","DOI":"10.1126\/sciadv.1600825","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T02:53:27Z","timestamp":1471488807000},"source":"Crossref","is-referenced-by-count":29,"title":["Rising sea levels will reduce extreme temperature variations in tide-dominated reef habitats"],"prefix":"10.1126","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7080-8406","authenticated-orcid":false,"given":"Ryan Joseph","family":"Lowe","sequence":"first","affiliation":[{"name":"Australian Research Council Centre of Excellence for Coral Reef Studies, University of Western Australia, Crawley, Western Australia 6009, Australia."},{"name":"School of Earth and Environment, University of Western Australia, Crawley, Western Australia 6009, Australia."},{"name":"University of Western Australia Oceans Institute, University of Western Australia, Crawley, Western Australia 6009, Australia."},{"name":"Western Australian Marine Science Institution, Floreat, Western Australia 6014, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Pivan","sequence":"additional","affiliation":[{"name":"School of Earth and Environment, University of Western Australia, Crawley, Western Australia 6009, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6211-7018","authenticated-orcid":false,"given":"James","family":"Falter","sequence":"additional","affiliation":[{"name":"Australian Research Council Centre of Excellence for Coral Reef Studies, University of Western Australia, Crawley, Western Australia 6009, Australia."},{"name":"School of Earth and Environment, University of Western Australia, Crawley, Western Australia 6009, Australia."},{"name":"University of Western Australia Oceans Institute, University of Western Australia, Crawley, Western Australia 6009, Australia."},{"name":"Western Australian Marine Science Institution, Floreat, Western Australia 6014, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Symonds","sequence":"additional","affiliation":[{"name":"School of Earth and Environment, University of Western Australia, Crawley, Western Australia 6009, Australia."},{"name":"University of Western Australia Oceans Institute, University of Western Australia, Crawley, Western Australia 6009, Australia."},{"name":"Western Australian Marine Science Institution, Floreat, Western Australia 6014, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8788-6910","authenticated-orcid":false,"given":"Renee","family":"Gruber","sequence":"additional","affiliation":[{"name":"Australian Research Council Centre of Excellence for Coral Reef Studies, University of Western Australia, Crawley, Western Australia 6009, Australia."},{"name":"School of Earth and Environment, University of Western Australia, Crawley, Western Australia 6009, Australia."},{"name":"University of Western Australia Oceans Institute, University of Western Australia, Crawley, Western Australia 6009, Australia."},{"name":"Western Australian Marine Science Institution, Floreat, Western Australia 6014, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"839","article-title":"Climate change, coral bleaching and the future of the world\u2019s coral reefs","volume":"50","author":"Hoegh-Guldberg O.","year":"1999","unstructured":"O. Hoegh-Guldberg, Climate change, coral bleaching and the future of the world\u2019s coral reefs. Mar. Freshw. Res. 50, 839\u2013866 (1999).","journal-title":"Mar. Freshw. Res."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152509"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"e5712","DOI":"10.1371\/journal.pone.0005712","article-title":"Coping with commitment: Projected thermal stress on coral reefs under different future scenarios","volume":"4","author":"Donner S. D.","year":"2009","unstructured":"S. D. Donner, Coping with commitment: Projected thermal stress on coral reefs under different future scenarios. PLOS One 4, e5712 (2009).","journal-title":"PLOS One"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00338-011-0825-4","article-title":"Effects of modeled tropical sea surface temperature variability on coral reef bleaching predictions","volume":"31","author":"van Hooidonk R.","year":"2012","unstructured":"R. van Hooidonk, M. Huber, Effects of modeled tropical sea surface temperature variability on coral reef bleaching predictions. Coral Reefs 31, 121\u2013131 (2012).","journal-title":"Coral Reefs"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00338-011-0812-9","article-title":"Predicting coral bleaching hotspots: The role of regional variability in thermal stress and potential adaptation rates","volume":"31","author":"Teneva L.","year":"2012","unstructured":"L. Teneva, M. Karnauskas, C. A. Logan, L. Bianucci, J. C. Currie, J. A. Kleypas, Predicting coral bleaching hotspots: The role of regional variability in thermal stress and potential adaptation rates. Coral Reefs 31, 1\u201312 (2012).","journal-title":"Coral Reefs"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s003380100151","article-title":"El Ni\u00f1o related coral bleaching in Palau, Western Caroline Islands","volume":"20","author":"Bruno J.","year":"2001","unstructured":"J. Bruno, C. Siddon, J. Witman, P. Colin, M. Toscano, El Ni\u00f1o related coral bleaching in Palau, Western Caroline Islands. Coral Reefs 20, 127\u2013136 (2001).","journal-title":"Coral Reefs"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF00265009","article-title":"Experimental evidence for high temperature stress as the cause of El Ni\u00f1o-coincident coral mortality","volume":"8","author":"Glynn P. W.","year":"1990","unstructured":"P. W. Glynn, L. D\u2019Croz, Experimental evidence for high temperature stress as the cause of El Ni\u00f1o-coincident coral mortality. Coral Reefs 8, 181\u2013191 (1990).","journal-title":"Coral Reefs"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.4319\/lo.2013.58.5.1531","article-title":"Two spatial scales in a bleaching event: Corals from the mildest and the most extreme thermal environments escape mortality","volume":"58","author":"Pineda J.","year":"2013","unstructured":"J. Pineda, V. Starczak, A. Tarrant, J. Blythe, K. Davis, T. Farrar, M. Berumen, J. C. B. da Silva, Two spatial scales in a bleaching event: Corals from the mildest and the most extreme thermal environments escape mortality. Limnol. Oceanogr. 58, 1531\u20131545 (2013).","journal-title":"Limnol. 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The reason behind this trend is a demand for providing information about the artefact in a more accessible way to the audience, for example, through online delivery or virtual reality. Other reasons might be to simplify and automate the management of artefacts. Having a \u2018digital copy\u2019 of artefacts, allows one to search an archive and plan its storage and dissemination in a comprehensive manner. With the increased digitalisation comes an increased use of artificial intelligence [AI] applications. AI can be very beneficial in classifying artefacts automatically through machine learning [ML] and natural language processing [NLP]. For example, an algorithm can identify the source and age of artefacts based on an image and can do this much faster for a large collection of photos than a human. Although AI provides many benefits, it also presents challenges: Sophisticated AI techniques require certain insights on how they work, need specialists to customise a solution, and require an existing large dataset to train an algorithm. Another challenge is that typical AI techniques are regarded as black boxes, which means they decide, but it is not obvious why a decision has been made. This chapter describes a project in collaboration with the South Australian Museum [SAM] on the application of AI to extract material lists from a description of artefacts. A large dataset to train an algorithm did not exist, and hence, a customised approach was required. The outcome of the project was the application of NLP in combination with easy-to-customise rules that can be applied by non-IT specialists. The resulting prototype achieved the extraction of materials from a large list of artefacts within seconds and a flexible solution that can be applied on other collections in the future.<\/jats:p>","DOI":"10.1108\/s0065-283020240000054004","type":"book-chapter","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T10:36:26Z","timestamp":1705055786000},"page":"41-55","source":"Crossref","is-referenced-by-count":1,"title":["Enhanced Material Management: Application of Natural Language Processing and Rule-based Modelling for Simplifying Storage Requirements in a Museum"],"prefix":"10.1108","author":[{"given":"Georg","family":"Grossmann","sequence":"first","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Beale","sequence":"additional","affiliation":[{"name":"South Australian Museum, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harkaran","family":"Singh","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Smith","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Nichols","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"140","reference":[{"volume-title":"Spatial analysis porta","year":"2023","author":"ALA","key":"2025122919371423900_s0065-283020240000054004_23.bib-1"},{"issue":"4","key":"2025122919371423900_s0065-283020240000054004_23.bib-2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1145\/2724727","article-title":"Fast image classification for monument recognition","volume":"8","author":"Amato","year":"2015","journal-title":"Journal on Computing and Cultural Heritage"},{"volume-title":"EMu","year":"2023","author":"Axiell","key":"2025122919371423900_s0065-283020240000054004_23.bib-3"},{"issue":"2","key":"2025122919371423900_s0065-283020240000054004_23.bib-4","first-page":"163","article-title":"Special issue on semantic web for cultural heritage","volume":"12","author":"Bikakis","year":"2021","journal-title":"Semantic Web"},{"issue":"3","key":"2025122919371423900_s0065-283020240000054004_23.bib-5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1145\/3497842","article-title":"Can BERT dig it? 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Histopathological studies have suggested that altered expression of the Neurokinin\u20101 receptor may also play a role in the pathogenesis of SIDS. It was hypothesised that genetic variants in three X\u2010chromosome\u2010encoded microRNA (miRNA\/miR), known to down\u2010regulate expression of the Neurokinin\u20101 receptor, may contribute to SIDS.<\/jats:p><\/jats:sec>Aim<\/jats:title>To identify sequence variants in the miRNAs within a study cohort (27 cases of SIDS and 28 controls) and determine if there was a difference in the frequencies in male and female SIDS infants.<\/jats:p><\/jats:sec>Methods<\/jats:title>Genomic DNA prepared from stored blood spots was amplified and sequenced to identify genetic variants in miR500A, miR500B and miR320D2.<\/jats:p><\/jats:sec>Results<\/jats:title>No novel variants in the miRNAs were identified in our study cohort. We identified one known single\u2010nucleotide polymorphism (SNP) in miR320D2: rs5907732\u2009G\/T, in both cases and controls. No significant difference in the SNP frequency was observed between male and female SIDS cases.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This pilot study suggests that sequence variants in three miRNAs do not contribute to the reported higher prevalence of SIDS in male infants and do not contribute to the pathogenesis of SIDS in our cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apa.16580","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T14:33:04Z","timestamp":1666449184000},"page":"273-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigating genetic variants in microRNA<\/scp> regulators of Neurokinin\u20101 receptor in sudden infant death syndrome"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4507-7752","authenticated-orcid":false,"given":"Zeeshan","family":"Shaukat","sequence":"first","affiliation":[{"name":"Clinical 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Since the introduction of the TeleStroke Programme, there has been monitoring of service outputs, including regional patient access to tertiary stroke specialist advice and reperfusion treatment; however, the impact of consultation with a stroke specialist via telehealth (videoconferencing or telephone) on the effectiveness and cost-effectiveness of stroke care and the drivers of cost-effectiveness has not been systematically evaluated.<\/jats:p>\n <\/jats:sec>\n \n Methods and analysis<\/jats:title>\n The aim of the case study was to examine the impact of consultation with a stroke specialist via telehealth on the effectiveness and cost-effectiveness of stroke and transient ischaemic attack care using a mixed methods approach. A categorical decision tree model will be constructed in collaboration with clinicians and programme managers. A before and after comparison using state-wide administrative datasets will be used to run the base model. If sample size and statistical power permits, the cases and comparators will be matched by stroke type and presence of CT scan at the initial site of presentation, age category and presenting hospital. The drivers of cost-effectiveness will be explored through stakeholder interviews. Data from the qualitative analysis will be cross-referenced with trends emerging from the quantitative dataset and used to guide the factors to be involved in subgroup and sensitivity analysis.<\/jats:p>\n <\/jats:sec>\n \n Ethics and dissemination<\/jats:title>\n Ethics approval for this case study has been granted from the Western Australian Country Health Service Human Research and Ethics Committee (RGS3076). Reciprocal approval has been granted from Curtin University Human Research Ethics Office (HRE2019-0740). Findings will be disseminated publicly through conference presentation and peer-review publications. Interim findings will be released as internal reports to inform the service development.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-043836","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T14:33:30Z","timestamp":1609943610000},"page":"e043836","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness and cost-effectiveness of TeleStroke consultations to support the care of patients who had a stroke presenting to regional emergency departments in Western Australia: an economic evaluation case study protocol"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6780-8117","authenticated-orcid":false,"given":"Christina","family":"Tsou","sequence":"first","affiliation":[{"name":"School of Public Health, Curtin University, Bentley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5703-6475","authenticated-orcid":false,"given":"Suzanne","family":"Robinson","sequence":"additional","affiliation":[{"name":"School of Public Health, Curtin University, Bentley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Boyd","sequence":"additional","affiliation":[{"name":"School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shruthi","family":"Kamath","sequence":"additional","affiliation":[{"name":"Western Australia Country Health Service, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Yeung","sequence":"additional","affiliation":[{"name":"Western Australia Country Health Service, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Waters","sequence":"additional","affiliation":[{"name":"Western Australia Country Health Service, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Gifford","sequence":"additional","affiliation":[{"name":"Western Australia Country Health Service, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Jamieson","sequence":"additional","affiliation":[{"name":"Western Australia Country Health Service, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5022-5281","authenticated-orcid":false,"given":"Delia","family":"Hendrie","sequence":"additional","affiliation":[{"name":"School of Public Health, Curtin University, Bentley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"2025121408130268000_11.1.e043836.1","unstructured":"Stroke Foundation . 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Journal of Surgery"],"published-print":{"date-parts":[[2021,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Breast magnetic resonance imaging (MRI) use for surgical staging is increasing, though remains controversial. We aimed to evaluate the accuracy of MRI in surgical decision\u2010making to determine if mastectomy prompted by MRI was appropriate.<\/jats:p><\/jats:sec>Methods<\/jats:title>A single\u2010centre observational study in Perth, Western Australia, with the inclusion of all preoperative and postoperative studies (e.g. involved margins after breast\u2010conserving surgery) undergoing staging breast MRI from 1 January 2015 to 26 August 2019. A standard protocol using gadolinium contrast was used. The reference standard was postoperative histopathology or, for studies without additional surgery after MRI following breast\u2010conserving surgery, the next and subsequent annual screening episodes. By reviewing the final histopathology, the medical case notes and multidisciplinary team decision process, we evaluated whether the reported MRI disease extent was accurate in prompting an appropriate upgrade to mastectomy. Outcomes are reported with descriptive statistics.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 130 cancers staged with MRI; seven were excluded as information was incomplete, 104 were performed preoperatively and 19 postoperatively. The majority (60%) staged lobular carcinoma (invasive 59%, in situ<\/jats:italic> 1%) compared to ductal carcinoma (invasive 31%, in situ<\/jats:italic> 8%). For preoperative MRI, half (54% \u2013 56\/104) underwent subsequent mastectomy. Of these, MRI prompted mastectomy in 45% (25\/56), all appropriate for disease extent. In the postoperative staging group, two mastectomies were performed, one planned before imaging, the other prompted when MRI diagnosed residual disease and confirmed on histopathology. No false\u2010negative staging MRI was identified.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In our cohort, MRI prompted an upgrade to mastectomy in 21% (26\/123), appropriate for cancer extent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.16887","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T04:40:40Z","timestamp":1619584840000},"page":"1772-1778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Is staging breast magnetic resonance imaging prompted upgrade to mastectomy appropriate?"],"prefix":"10.1111","volume":"91","author":[{"given":"Thilina","family":"Jayaratne","sequence":"first","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0035-7515","authenticated-orcid":false,"given":"Yang Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Surgery Sir Charles Gairdner Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Jacques","sequence":"additional","affiliation":[{"name":"Department of Research Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"Institute for Health Research The University of Notre Dame Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravinder","family":"Dhillon","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"BreastScreenWA Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"BreastScreenWA Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharmistha","family":"Bose","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"BreastScreenWA Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Bourke","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"BreastScreenWA Perth Western Australia Australia"},{"name":"Faculty of Health and Medical Sciences The University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Dessauvagie","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"Anatomical Pathology PathWest Laboratory Medicine WA Perth Western Australia Australia"},{"name":"Anatomical Pathology Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6906-588X","authenticated-orcid":false,"given":"Glen","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"BreastScreenWA Perth Western Australia Australia"},{"name":"Faculty of Health and Medical Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"Medical School Curtin University Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1016\/s0140-6736(09)62070-5"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1200\/JCO.2007.15.2108"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1016\/j.mric.2010.02.005"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1016\/j.crad.2013.07.016"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1111\/1754-9485.13009"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1056\/nejmoa065447"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1148\/radiol.12120629"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1200\/jco.2008.21.5756"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.1186\/bcr767"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1097\/sla.0b013e31827a8d17"},{"doi-asserted-by":"publisher","key":"e_1_2_9_12_1","DOI":"10.1007\/s10549-009-0616-6"},{"unstructured":"Health AGD of. 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Audit of screening performance should reflect appropriate population targeting.<\/jats:p><\/jats:sec>Methods<\/jats:title>An observational study on consecutively screened high\u2010risk women, assessment of the contralateral breast staging a new cancer, or surveillance in women with prior breast cancer or high\u2010risk lesion in Perth, Western Australia. All breast MRI studies from 1 January 2015 to 7 September 2018 were included. Studies were 3T comprising T2, DWI, ADC and T1\u2010weighted +\/\u2010 fat saturation +\/\u2010 IV gadolinium, +\/\u2010 subtraction. DCE was read on the dynamics or DynaCAD (Invivo, Gainesville, FL, USA). Fellowship\u2010trained breast radiologists blindly double\u2010read by consensus; additional reader\/s arbitrated. The reference standard was the histopathology result or cancer registry notification for cancer diagnoses and benign biopsies, benign follow\u2010up imaging or subsequent screening MRI.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 993 MRI studies in 554 women, 870 eligible MRI were performed in 471 women, and 706 had a reference standard. Median age was 44\u00a0years (range 18\u201380). The majority of studies (65% 457\/706) were screening Medicare rebate\u2010eligible high familial risk; 26% for surveillance after a breast cancer or contralateral staging; 6% screened BRCA carriers. Eleven cancers were diagnosed, eight were MRI\u2010detected. Only two of these were at high\u2010risk screening MRI. Five were detected at staging contralateral ILC, after negative 2D mammography and ultrasound. Cancer prevalence was highest for staging contralateral ILC, at 600\/10,000 MRI, for high\u2010risk screening 77\/10,000 MRI and surveillance 116\/10,000 MRI.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Cancers were predominantly detected in women undergoing preoperative staging of new invasive lobular carcinoma in the contralateral breast, rather than the Medicare rebate\u2010eligible high\u2010risk screening group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13009","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T07:26:56Z","timestamp":1581319616000},"page":"220-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Does Medicare\u2010eligible high\u2010risk breast cancer screening MRI target the right women?"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6906-588X","authenticated-orcid":false,"given":"Glen","family":"Lo","sequence":"first","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"BreastScreen WA Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"},{"name":"Curtin University Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9438-7140","authenticated-orcid":false,"given":"Aden","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Jacques","sequence":"additional","affiliation":[{"name":"Department of Research Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"Institute for Health Research The University of Notre Dame Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravinder","family":"Dhillon","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"BreastScreen WA Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"BreastScreen WA Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thilina","family":"Jayaratne","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharmistha","family":"Bose","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"BreastScreen WA Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Bourke","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"BreastScreen WA Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,9]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Australian Government Department of Health.MRI (Magnetic Resonance Imaging) breast services Q&A (questions and answers) [Internet].Australian Government Department of Health and Ageing;2013[Cited 2019 May 5]. 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Current standard of care tests (urinary albumin:creatinine ratio (ACR) , estimated glomerular filtration rate (eGFR)) have limited ability to predict CKD progression. PromarkerD is a novel blood test that has prognostic value for the onset\/progression of early-stage renal function decline in T2D. The ability of PromarkerD to predict later-stage renal decline in participants in the CANVAS trial was explored.<\/jats:p>\n Concentrations of PromarkerD biomarkers (CD5L, ApoA4, IGFBP3) were measured by mass spectrometry at baseline in 3,525 CANVAS participants (n=1,179 placebo arm, n=2,346 canagliflozin arm) and combined with clinical data (age, serum HDL-cholesterol, eGFR) to provide PromarkerD scores (0 to 100%) for adverse renal outcomes. Cox regression was used to assess the ability of PromarkerD to predict three composites: i) \u226540% eGFR decline, ESRD, or renal death ii) outcome 1 or cardiovascular disease death and iii) outcome 2 or progression to macroalbuminuria.<\/jats:p>\n At baseline, the participants (mean age 62.7 years, 67% males, median diabetes duration 12.5 years) had mean eGFR 77 mL\/min\/1.73m2, median ACR 11.6 mg\/g and mean PromarkerD score 34.5%. During a mean 5.6 years of follow-up, 138 (3.9%) , 380 (10.8%) and 427 (12.1%) participants experienced composite outcomes 1 to 3, respectively. After adjusting for allocated treatment, each 10% increase in PromarkerD score was significantly associated with higher rates of adverse outcomes (outcome 1: HR 1.22 [1.to 1.38], outcome 2: HR 1.28 [1.to 1.37], outcome 3: HR 1.13 [1.to 1.21], all P\u22640.001) with only modest attenuation after adjustment for both eGFR and ACR (all P\u22640.013) .<\/jats:p>\n This post-hoc analysis of CANVAS data shows that PromarkerD can be used to predict late as well as early-stage renal decline in people with T2D.<\/jats:p>\n \n Disclosure<\/jats:title>\n K.E.Peters: None. P.Di prinzio: None. S.Bringans: None. W.A.Davis: None. T.Davis: Advisory Panel; Merck Sharp & Dohme Corp., Novo Nordisk, Roche Diagnostics, Research Support; Novo Nordisk, Speaker's Bureau; Novo Nordisk. R.J.Lipscombe: Employee; Proteomics International, Stock\/Shareholder; Proteomics International. M.K.Hansen: Employee; Janssen Research & Development, LLC.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db22-855-p","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:35:25Z","timestamp":1653975325000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["855-P: PromarkerD Predicts Late-Stage Renal Function Decline in Type 2 Diabetes in the Canagliflozin Cardiovascular Assessment Study (CANVAS)"],"prefix":"10.2337","volume":"71","author":[{"given":"KIRSTEN E.","family":"PETERS","sequence":"first","affiliation":[{"name":"Perth, Australia, Fremantle, Australia, Spring House, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PATSY DI","family":"PRINZIO","sequence":"additional","affiliation":[{"name":"Perth, Australia, Fremantle, Australia, Spring House, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SCOTT","family":"BRINGANS","sequence":"additional","affiliation":[{"name":"Perth, Australia, Fremantle, Australia, Spring House, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WENDY A.","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Perth, Australia, Fremantle, Australia, Spring House, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIMOTHY","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Perth, Australia, Fremantle, Australia, Spring House, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD J.","family":"LIPSCOMBE","sequence":"additional","affiliation":[{"name":"Perth, Australia, Fremantle, Australia, Spring House, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHAEL K.","family":"HANSEN","sequence":"additional","affiliation":[{"name":"Perth, Australia, Fremantle, Australia, Spring House, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/855-P\/145718\/855-P-PromarkerD-Predicts-Late-Stage-Renal","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/855-P\/145718\/855-P-PromarkerD-Predicts-Late-Stage-Renal","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:35:25Z","timestamp":1653975325000},"score":7.588775,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/855-P\/145718\/855-P-PromarkerD-Predicts-Late-Stage-Renal"}},"issued":{"date-parts":[[2022,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db22-855-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2022,6,1]]},"article-number":"855-P"},{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:21:47Z","timestamp":1783016507972,"version":"3.54.6"},"reference-count":0,"publisher":"Wiley","issue":"S7","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n In Alzheimer\u2019s disease (AD), astrocytes undergo reactive changes that can exert both protective and detrimental effects on neurons, thereby influencing neuronal survival and contributing to disease progression. Increasing attention has been directed toward elucidating the mechanisms underlying astrocyte dysfunction and neuroinflammation to identify novel therapeutic targets. Butyrate\u2014a short\u2010chain fatty acid produced by gut microbiota\u2014has demonstrated anti\u2010inflammatory and neuroprotective properties. Similarly, lauric acid (LA), a medium\u2010chain fatty acid, has shown potential in attenuating amyloid\u2010beta (A\u03b2)\u2010induced neurotoxicity, enhancing mitochondrial function, and modulating neuronal excitability. Despite these findings, the mechanisms by which they modulate astrocyte and neuronal function remain poorly understood. This study investigates the effects of butyrate and LA on oxidative stress, mitochondrial dysfunction, and lipidomic alterations in human\u2010induced pluripotent stem cells (iPSCs)\u2010derived astrocytes, neurons, and spontaneous cultures.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n Astrocytes, neurons, and spontaneous co\u2010cultures were differentiated from iPSCs derived from a healthy donor. Cultures were treated with synthetic A\u03b2 (20 \u00b5M), sodium butyrate (NaB) (100 \u00b5M), or LA (100 \u00b5M), alone and in combination. Oxidative stress, mitochondrial dysfunction and the lipidomic changes of these cells was measured using Quantitative PCR, Catalase activity, Mitochondrial ToxGlo\u2122 Assay and Liquid Chromatography\u2010Mass Spectrometry (LC\u2010MS) respectively.<\/jats:p>\n <\/jats:sec>\n \n Result<\/jats:title>\n A\u03b2 exposure significantly suppressed catalase expression in astrocytes, indicating elevated oxidative stress. Treatment with NaB and LA exhibit partial restoration of catalase expression, with the most effects observed in mixed cultures, suggesting enhanced cellular resilience. Furthermore, expression of Mitofusin\u20101, a key regulator of mitochondrial fusion, was downregulated following A\u03b2 treatment. Functional assays revealed butyrate and LA enhance antioxidant enzyme activity and improved mitochondrial integrity over time, with astrocytes and mixed cultures showing the most pronounced protective effect. The lipid profiles indicate that A\u03b2 induces greater lipid variation in neurons compared to astrocytes and spontaneous cultures.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study highlights the modulatory roles of butyrate and lauric acid on oxidative stress pathways, mitochondrial dynamics, and lipidomic profiles in iPSC\u2010derived brain cell cultures subjected to amyloid\u2010beta toxicity. These results support further exploration of butyrate and LA as therapeutic agents targeting neuroinflammation and metabolic dysregulation in AD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz70861_108390","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T19:03:32Z","timestamp":1766516612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Butyrate and Lauric Acid Attenuate Amyloid\u2010Beta\u2010Induced Oxidative, Mitochondrial, and Lipidomic Dysregulation in Human iPSC\u2010Derived Astrocytes and Neurons"],"prefix":"10.1002","volume":"21","author":[{"given":"RM. Uththara Sachinthanie","family":"Senarath","sequence":"first","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Alzheimer's Research Australia, Perth, Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotta E","family":"Oikari","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute, Herston, QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Bharadwaj","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Alzheimer's Research Australia, Perth, Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Jayasena","sequence":"additional","affiliation":[{"name":"Western Sydney University, Sydney, NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Whiley","sequence":"additional","affiliation":[{"name":"Australian National Phenome Centre, Health Futures Institute, Murdoch University, Murdoch, Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Ryan","sequence":"additional","affiliation":[{"name":"Australian National Phenome Centre, Health Futures Institute, Murdoch University, Murdoch, Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph N","family":"Martins","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Alzheimer's Research Australia, Perth, Western Australia Australia"},{"name":"Lions Alzheimer's Foundation, Perth, Western Australia Australia"},{"name":"Department of Biomedical Sciences, Macquarie University, Macquarie Park, NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warnakulasuriya Mary Ann Dipika Binosha","family":"Fernando","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Alzheimer\u2019s Research Australia, Perth, Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,23]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz70861_108390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T20:24:24Z","timestamp":1767817464000},"score":7.5884485,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz70861_108390"}},"issued":{"date-parts":[[2025,12]]},"references-count":0,"journal-issue":{"issue":"S7","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/alz70861_108390"],"URL":"https:\/\/doi.org\/10.1002\/alz70861_108390","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e108390"},{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:14:10Z","timestamp":1777940050766,"version":"3.51.4"},"reference-count":92,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Market Research"],"published-print":{"date-parts":[[2024,9]]},"abstract":"Despite the concept of a suggestive brand name existing for over one hundred years (Viehoever, 1920), the prevalence of suggestive versus non-suggestive brand names has not been documented. Previously, to do so extensively would have taken considerable time and money. We now show that artificial intelligence can replace manual coding with increased accuracy. We found the coding performances of Chat GPT-4 are 34% more accurate than GPT-3.5 and 44% more accurate than human coders. Systematically expanding our research to over 4,600 brands from consumer goods, services, and durables in major English-speaking markets (United Kingdom, United States, and Australia), we find that overall, slightly more than a quarter of all brand names are suggestive - ranging from 10% of durables to 56% of service brands. Further, we expand the suggestiveness research to non-brand name elements of almost 600 Distinctive Assets (e.g., colours, logos) across consumer goods, services, durables, and retailers (in the same three countries), finding that two in five are suggestive. The brand name and Distinctive Asset prevalence distributions are positively skewed, with most categories falling beneath the respective averages. Furthermore, regarding performance, on average, suggestive Distinctive Assets display lower levels of Fame and Uniqueness than non-suggestive Distinctive Assets.<\/jats:p>","DOI":"10.1177\/14707853241251954","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T18:15:39Z","timestamp":1715019339000},"page":"631-649","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["How prevalent are suggestive brand names and Distinctive Assets? 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Methods: Eligible pts were enrolled in two strata: (1) inoperable PC in head or body without metastases (LAD) or (2) resected PC at high risk of relapse (Surg). G was given at 1000 mg\/m2<\/jats:sup> weekly for 3 wks followed by 1 wk rest and a 5\u20136 wk period of RT and concurrent CI 5FU (200 mg\/m2<\/jats:sup>\/day). The defined target volume was treated to 54Gy in 30# of 1.8Gy (LAD) or 45Gy in 25# (Surg). After 4 wks rest, G was given for 12 wks. Results: 63 pts were enrolled: 39 females, 24 males; mean age 61 yr, range 31\u201379; 43% ECOG PS 0, 51% PS 1, 5% PS 2. Follow-up was 2 yr. 1- and 2-yr survival (KM) were 46% and 10% (LAD) and 59% and 27% (Surg). 1- and 2-yr local control (KM) were 48% and 21% (LAD) and 80% and 80% (Surg). The % planned dose delivered was (i) G pre RT: 87.6% (LAD)\/94.6% (Surg); (ii) 5FU: 100.7%\/96.4%; (iii) RT: 96.2%\/99.5%; (iv) G post RT: 67.4%\/65.3%. The baseline CA 19.9 level was significantly associated with a shorter TTPD (p=0.0002) and a shorter survival time (p=0.0071). Using Time Dependent Covariate analysis, CA 19.9 levels were strongly associated with TTPD and survival (both p < 0.0001); a person with a 10-fold higher level has a 1.95-fold higher risk of death over the next time period than their counterpart (95% CI: 1.53\u20132.49-fold). In 22 pts we found no statistically significant associations between outcome and mutations in K-RAS or TP53 or with microsatellite instability. Grade 3\/4 hematological and non-hematological toxicity was reported by 29 (46%) and 42 pts (67%), respectively. There was one treatment-related death. Conclusions: This approach to treatment is safe and promising, with good local control for a substantial proportion of patients, and merits testing in a randomized trial. <\/jats:p> [Table: see text] <\/jats:p> [Table: see text] <\/jats:p>","DOI":"10.1200\/jco.2006.24.18_suppl.4104","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T19:52:56Z","timestamp":1583783576000},"page":"4104-4104","source":"Crossref","is-referenced-by-count":0,"title":["Combined modality therapy for pancreatic carcinoma: An Australian Pancreatic Cancer Group study of the addition of gemcitabine (G) to concurrent infusional 5-fluorouracil (CI 5FU) and 3D conformal radiotherapy (RT)\u2014Final outcomes"],"prefix":"10.1200","volume":"24","author":[{"given":"D.","family":"Goldstein","sequence":"first","affiliation":[{"name":"Prince of Wales Hospital, Randwick, Australia; Sir Charles Gairdner Hospital, Perth, Australia; Border Medical Oncology, Wodonga, Australia; Ashford Cancer Centre, Ashford, Australia; 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St George Hospital, Kogarah, Australia; Alfred Hospital, Melbourne, Australia; University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Underhill","sequence":"additional","affiliation":[{"name":"Prince of Wales Hospital, Randwick, Australia; Sir Charles Gairdner Hospital, Perth, Australia; Border Medical Oncology, Wodonga, Australia; Ashford Cancer Centre, Ashford, Australia; Princess Alexandra Hospital, Brisbane, Australia; St George Hospital, Kogarah, Australia; Alfred Hospital, Melbourne, Australia; University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Kotasek","sequence":"additional","affiliation":[{"name":"Prince of Wales Hospital, Randwick, Australia; Sir Charles Gairdner Hospital, Perth, Australia; Border Medical Oncology, Wodonga, Australia; Ashford Cancer Centre, Ashford, Australia; Princess Alexandra Hospital, Brisbane, Australia; St George Hospital, Kogarah, Australia; Alfred Hospital, Melbourne, Australia; University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Prince of Wales Hospital, Randwick, Australia; Sir Charles Gairdner Hospital, Perth, Australia; Border Medical Oncology, Wodonga, Australia; Ashford Cancer Centre, Ashford, Australia; Princess Alexandra Hospital, Brisbane, Australia; St George Hospital, Kogarah, Australia; Alfred Hospital, Melbourne, Australia; University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Links","sequence":"additional","affiliation":[{"name":"Prince of Wales Hospital, Randwick, Australia; Sir Charles Gairdner Hospital, Perth, Australia; Border Medical Oncology, Wodonga, Australia; Ashford Cancer Centre, Ashford, Australia; Princess Alexandra Hospital, Brisbane, Australia; St George Hospital, Kogarah, Australia; Alfred Hospital, Melbourne, Australia; University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Prince of Wales Hospital, Randwick, Australia; Sir Charles Gairdner Hospital, Perth, Australia; Border Medical Oncology, Wodonga, Australia; Ashford Cancer Centre, Ashford, Australia; Princess Alexandra Hospital, Brisbane, Australia; St George Hospital, Kogarah, Australia; Alfred Hospital, Melbourne, Australia; University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Iacopetta","sequence":"additional","affiliation":[{"name":"Prince of Wales Hospital, Randwick, Australia; Sir Charles Gairdner Hospital, Perth, Australia; Border Medical Oncology, Wodonga, Australia; Ashford Cancer Centre, Ashford, Australia; Princess Alexandra Hospital, Brisbane, Australia; St George Hospital, Kogarah, Australia; 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The research uses primary field data drawn from West Bengal, India, where the progressive feminisation of agriculture has been well\u2010documented. We employ a paired comparison technique to explore how gender impacts the preferences towards different attributes of pumping technology. 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J Rural Health"],"published-print":{"date-parts":[[2012,12]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To determine the impact of remoteness on A<\/jats:styled-content>boriginal and non\u2010A<\/jats:styled-content>boriginal myocardial infarction incidence rates in men and women of different ages.<\/jats:p><\/jats:sec>Design<\/jats:title>Descriptive study.<\/jats:p><\/jats:sec>Setting<\/jats:title>W<\/jats:styled-content>estern A<\/jats:styled-content>ustralia.<\/jats:p><\/jats:sec>Participants<\/jats:title>Incident cases of myocardial infarction in W<\/jats:styled-content>estern A<\/jats:styled-content>ustralia from 2000\u20132004 identified from person\u2010linked files of hospital and mortality records. Analysis was undertaken for A<\/jats:styled-content>boriginal and non\u2010A<\/jats:styled-content>boriginal populations, separately and combined, by broad age group, sex and remoteness.<\/jats:p><\/jats:sec>Main outcome measure<\/jats:title>Incidence of myocardial infarction.<\/jats:p><\/jats:sec>Results<\/jats:title>In the combined analysis, age\u2010standardised incidence was significantly higher for men in very remote areas (rate ratio 1.31: 95% confidence interval (CI<\/jats:styled-content>), 1.19\u20131.45) and in women in both regional (rate ratio 1.12: 95% CI<\/jats:styled-content>, 1.01\u20131.20) and very remote (rate ratio 2.05: 95% CI<\/jats:styled-content>, 1.75\u20132.41) areas. A<\/jats:styled-content>boriginal rates were substantially higher than non\u2010A<\/jats:styled-content>boriginal rates in all substrata. Compared with metropolitan people, regional A<\/jats:styled-content>boriginal men and very remote non\u2010A<\/jats:styled-content>boriginal men aged 25\u201354 years had significantly higher incidence rates. For the remaining rural strata, there was either no geographical disadvantage or inconclusive findings.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Non\u2010metropolitan disadvantage in myocardial infarction rates is confirmed in regional areas and women in very remote areas. This disadvantage is partly explained by the high rates in A<\/jats:styled-content>boriginal people. Non\u2010metropolitan dwellers are not uniformly disadvantaged, reflecting the interplay of the many factors contributing to the complex relationship between myocardial infarction incidence and sex, age, A<\/jats:styled-content>boriginality and residence. Aboriginal W<\/jats:styled-content>estern A<\/jats:styled-content>ustralians in all regions and young non\u2010A<\/jats:styled-content>boriginal men living in very remote areas need to be targeted to reduce disparities in myocardial infarction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1440-1584.2012.01314.x","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T17:06:13Z","timestamp":1353949573000},"page":"305-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Complex impact of remoteness on the incidence of myocardial infarction in A<\/scp>boriginal and non\u2010A<\/scp>boriginal people in W<\/scp>estern A<\/scp>ustralia"],"prefix":"10.1111","volume":"20","author":[{"given":"Judith M.","family":"Katzenellenbogen","sequence":"first","affiliation":[{"name":"Combined Universities Centre for Rural Health University of Western Australia Geraldton Western Australia Australia"},{"name":"Curtin Health Innovation Research Institute Curtin University Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank M.","family":"Sanfilippo","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Geraldton Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S. T.","family":"Hobbs","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Geraldton Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom G.","family":"Briffa","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Geraldton Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew W.","family":"Knuiman","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Geraldton Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyn","family":"Dimer","sequence":"additional","affiliation":[{"name":"Heart Foundation of Western Australia Subiaco Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter L.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Heart Research Institute Sir Charles Gairdner Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra C.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Combined Universities Centre for Rural Health University of Western Australia Geraldton Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyn240"},{"key":"e_1_2_8_3_1","unstructured":"BeggS VosT GossJet\u2009al.The burden of disease and injury in Australia. Report No.: PHE 82.Canberra:AIHW 2007."},{"key":"e_1_2_8_4_1","unstructured":"Australian Bureau of Statistics.Experimental life tables for Aboriginal and Torres Strait Islander Australians 2005\u20132007. Report No.: Cat. no. 3302.0.55.003.Canberra:ABS 2009."},{"key":"e_1_2_8_5_1","unstructured":"Australian Institute of Health and Welfare.Australia's Health 2010. Report No.: Cat. no. AUS 122.Canberra:AIHW 2010."},{"key":"e_1_2_8_6_1","volume-title":"Monitoring the Incidence of Cardiovascular Disease in Australia","author":"Jamrozik K","year":"2001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2009.tb02572.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2010.08.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2009.tb02416.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.1999.tb01297.x"},{"key":"e_1_2_8_11_1","unstructured":"Australian Institute of Health and Welfare.National best practice guidelines for collecting Indigenous status in health data sets. Report No.: Cat. no. IHW 29.Canberra:AIHW 2010."},{"key":"e_1_2_8_12_1","unstructured":"YoungMJ.Assessing the quality of identification of Aboriginal and Torres Strait Islander people in Western Australia Hospital Data 2000. Report No.: Health Information Centre Occasional Paper 13 ISSN 132 7252.Perth:Department of Health of Western Australia 2001."},{"key":"e_1_2_8_13_1","volume-title":"Australian Standard Geographical Classification (ASGC) 2001","author":"Australian Bureau of Statistics","year":"2001"},{"key":"e_1_2_8_14_1","unstructured":"Geographic Information Systems Epidemiology Branch Public Health Division Department of Health Health Geographical Classification Version 3.0 2006 Department of Health WA Perth"},{"key":"e_1_2_8_15_1","unstructured":"Australian Bureau of Statistics.Australian demographic statistics Mar 2008 (Report Catalogue Number 3101.0).Canberra:ABS 2008."},{"key":"e_1_2_8_16_1","volume-title":"Modern Epidemiology","author":"Rothman KJ","year":"2008"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000221702.75002.66"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2008.tb01621.x"},{"key":"e_1_2_8_19_1","volume-title":"The Social and Emotional Wellbeing of Aboriginal Children and Young People: Summary Booklet","author":"Zubrick SR","year":"2005"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2012.01.005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-6405.2007.00079.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2010.tb04036.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1071\/AH090549"},{"key":"e_1_2_8_24_1","volume-title":"Cultural Respect Framework for Aboriginal and Torres Strait Islander Health","author":"Australian Health Ministers\u2019 Advisory Council \u2013 Standing Committee for Aboriginal and Torres Strait Islander Health Working Party","year":"2004"},{"key":"e_1_2_8_25_1","unstructured":"ProutS.On the move? Indigenous temporary mobility practices in Australia. Report No.: CAEPR Working Paper No. 48\/2008.Canberra:Centre for Aboriginal Economic Policy Research ANU;2008."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-286"}],"container-title":["Australian Journal of Rural Health"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1440-1584.2012.01314.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1440-1584.2012.01314.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T22:30:34Z","timestamp":1697409034000},"score":7.5877423,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1440-1584.2012.01314.x"}},"issued":{"date-parts":[[2012,11,26]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/j.1440-1584.2012.01314.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1440-1584.2012.01314.x","archive":["Portico"],"ISSN":["1038-5282","1440-1584"],"issn-type":[{"value":"1038-5282","type":"print"},{"value":"1440-1584","type":"electronic"}],"published":{"date-parts":[[2012,11,26]]},"assertion":[{"value":"2012-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:27:25Z","timestamp":1789018045462,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["esskajournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n The purpose of the study was to identify the safety and effectiveness of an accelerated (AR) versus conservative (CR) rehabilitation regimen following surgical repair of proximal hamstring tendon avulsions.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This prospective randomized controlled trial (RCT) allocated patients undergoing proximal hamstring tendon repair to either a braced, partial weight\u2010bearing rehabilitation regime (CR\u2009=\u200930) or an accelerated, unbraced regime, which permitted full weight\u2010bearing as tolerated (AR\u2009=\u200927). Patients were evaluated pre\u2010operatively and at 6 weeks, 3 and 6 months post\u2010surgery, via patient\u2010reported outcome measures (PROMs), patient satisfaction and global rating of change (GRC) scores. Objective measures, including the single (SHD), triple (THD) and triple crossover (TCHD) hop tests, were assessed at 6 months, as was peak isokinetic knee extensor and flexor torque.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 57 patients recruited, 4 were excluded from the CR group (2 infections; 2 re\u2010injuries). The CR group contained 57% males with a mean age of 45.6 (standard deviation [SD]\u2009=\u200913.4). The AR group contained 44% males with a mean age of 50.5 (SD\u2009=\u200911.8). Therefore, 53 patients (CR\u2009=\u200926, AR\u2009=\u200927) were reviewed at the final 6\u2010month follow\u2010up. Within\u2010group analyses showed that both groups significantly improved in all PROMs (\n p<\/jats:italic>\n \u2009<\u20090.05). No significant differences were observed between groups for satisfaction, GRC scores, knee extensor torque, knee flexor torque, limb symmetry indices, re\u2010injuries or complications at 6 months.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This RCT has highlighted the safety and efficacy of a post\u2010operative rehabilitation pathway that includes weight\u2010bearing as tolerated, without bracing, in patients after proximal hamstring tendon repair.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n Level I.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ksa.70030","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T10:28:38Z","timestamp":1757413718000},"page":"4412-4425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Accelerated rehabilitation after proximal hamstring avulsion repair is safe and effective: Outcomes from randomized controlled trial of two different rehabilitation regimes"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8465-8923","authenticated-orcid":false,"given":"Randeep S.","family":"Aujla","sequence":"first","affiliation":[{"name":"University Hospitals of Leicester Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Edwards","sequence":"additional","affiliation":[{"name":"Curtain University School of Allied Health Perth Western Australia Australia"},{"name":"Orthopaedic Research Foundation of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Cecchi","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahbaz","family":"Malik","sequence":"additional","affiliation":[{"name":"Worcestershire Acute Hospitals NHS Trust Worcester 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brace immobilization needed following surgical repair of proximal hamstring tears?","volume":"7","author":"Lazaro LE","year":"2019","journal-title":"Orthop J Sports 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Surgery, Sports Traumatology, Arthroscopy"],"language":"en","link":[{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ksa.70030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ksa.70030","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ksa.70030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T15:23:34Z","timestamp":1787325814000},"score":7.5877423,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1002\/ksa.70030"}},"issued":{"date-parts":[[2025,9,9]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/ksa.70030"],"URL":"https:\/\/doi.org\/10.1002\/ksa.70030","archive":["Portico"],"ISSN":["0942-2056","1433-7347"],"issn-type":[{"value":"0942-2056","type":"print"},{"value":"1433-7347","type":"electronic"}],"published":{"date-parts":[[2025,9,9]]},"assertion":[{"value":"2025-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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SYSTEM"],"prefix":"10.5220","author":[{"given":"D.","family":"Paul","sequence":"first","affiliation":[{"name":"Schizophrenia Research Institute, Australia"},{"name":"University of Newcastle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"A. Henskens","sequence":"additional","affiliation":[{"name":"Schizophrenia Research Institute, Australia"},{"name":"University of Newcastle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"M. Loughland","sequence":"additional","affiliation":[{"name":"Schizophrenia Research Institute, Australia"},{"name":"University of Newcastle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bridge","sequence":"additional","affiliation":[{"name":"Schizophrenia Research Institute, Australia"},{"name":"University of Newcastle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"McCabe","sequence":"additional","affiliation":[{"name":"Schizophrenia Research Institute, Australia"},{"name":"University of Newcastle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"J. Carr","sequence":"additional","affiliation":[{"name":"Schizophrenia Research Institute, Australia"},{"name":"University of New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"V. Catts","sequence":"additional","affiliation":[{"name":"Schizophrenia Research Institute, Australia"},{"name":"University of Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Jablensky","sequence":"additional","affiliation":[{"name":"Schizophrenia Research Institute, Australia"},{"name":"University of Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"T. Michie","sequence":"additional","affiliation":[{"name":"Schizophrenia Research Institute, Australia"},{"name":"University of Newcastle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"J. Mowry","sequence":"additional","affiliation":[{"name":"Schizophrenia Research Institute, Australia"},{"name":"University of Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Pantelis","sequence":"additional","affiliation":[{"name":"Schizophrenia Research Institute, Australia"},{"name":"University of Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Schall","sequence":"additional","affiliation":[{"name":"Schizophrenia Research Institute, Australia"},{"name":"University of Newcastle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"J. Scott","sequence":"additional","affiliation":[{"name":"Schizophrenia Research Institute, Australia"},{"name":"University of Newcastle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3171","event":{"name":"International Conference on Health Informatics","location":"Vilamoura, Algarve, Portugal","start":{"date-parts":[[2012,2,1]]},"end":{"date-parts":[[2012,2,4]]}},"container-title":["Proceedings of the International Conference on Health Informatics"],"original-title":["IT DEVELOPMENT AND MANAGEMENT OF A LIVE E-RESEARCH SYSTEM"],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:06:43Z","timestamp":1774008403000},"score":7.587517,"resource":{"primary":{"URL":"https:\/\/www.scitepress.org\/DigitalLibrary\/Link.aspx?doi=10.5220\/0003705800000601"}},"subtitle":[""],"issued":{"date-parts":[[2012]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5220\/0003705800000601","published":{"date-parts":[[2012]]}},{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T03:08:38Z","timestamp":1771902518981,"version":"3.50.1"},"reference-count":0,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"16_suppl","funder":[{"name":"Western Australian Cancer and Palliative Care Network Fellowship Grant"}],"content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2023,6,1]]},"abstract":" e18027 <\/jats:p> Background: Malnutrition is a major complication of head and neck cancer and has pertinent implications on survival. Methods: We performed a retrospective analysis of 320 patients with head and neck cancer from a tertiary hospital in Western Australia from 2013 - 2021. Weight and albumin were collected from different timepoints in the patient\u2019s journey, including at diagnosis and end of treatment. Treatments received, recurrences and survival data were also collected. Initial univariate analyses were performed using Chi squares. Results: Median follow-up was 2.6 years (range 16 days to 9 years). 44% of patients underwent curative intent radiotherapy or chemoradiotherapy, 38% had surgery (+\/- adjuvant therapies), 9% had palliative treatments, and 9% had best supportive care. At diagnosis, 12% of patients were hypoalbuminemic, 75% had normal albumin, and albumin was unknown in 13%. Hypoalbuminemia at diagnosis strongly correlated with lower survival compared with patients with normal albumin with 1 year OS (1YS) 35% vs 82% (p < 0.00001). Patients with normal albumin at diagnosis had higher disease-free survival compared to hypoalbuminemic patients (56% vs 32%, p = 0.04). By the end of treatment, 22% of patients were hypoalbuminemic, 48% had normal albumin, and 30% were unknown. Hypoalbuminemia at end of treatment was also prognostic, with 1YS 72% vs 89% and 2YS 52% vs 72% (p = 0.002) when compared to patients with normal albumin. Of patients who were treated with curative intent, there was no significant difference in the rate of relapse (38% vs 35%, p = 0.67). By Body Mass Index (BMI) at diagnosis, 5% of patients were severely underweight (BMI < 16.5), 7% underweight (BMI 16.5-18.4), 34% healthy (BMI 18.5-24.9), 31% overweight (BMI 25.0-29.9), and 22.5% obese (BMI \u226530). BMI at diagnosis was highly prognostic with 1YS 37% in severely underweight patients, 67% underweight, 75% healthy, 91% overweight, and 94% in obese individuals (p < 0.00001). By end of treatment, 7% were severely underweight, 9% were underweight, 42% were healthy, 28% were overweight, and 14% were obese. Low BMI at end of treatment was also associated with inferior outcomes with 1YS 53% in severely underweight individuals, 76% underweight, 83% healthy, 97% overweight, and 95% in obese patients (p < 0.00001). Median weight loss from diagnosis to end of treatment was 6kg (range from 34kg loss to 15kg gain), and median % body weight change was -7.5% (range from -28% to +26%). Percentage body weight loss of > 20% was associated with worse survival with 65% mortality during the study period compared with 35% in patients who lost \u226420% body weight. 1YS was 71% in patients who lost > 20% body weight compared to 86%, although this did not reach statistical significance (p = 0.097). Conclusions: Hypoalbuminemia and low BMI at diagnosis and end of treatment, in addition to % body weight loss of > 20% were all associated with worse survival in head and neck cancer patients. <\/jats:p>","DOI":"10.1200\/jco.2023.41.16_suppl.e18027","type":"journal-article","created":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T16:00:42Z","timestamp":1685894442000},"page":"e18027-e18027","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Hypoalbuminemia, body mass index, and weight loss as predictors of outcomes in head and neck cancer."],"prefix":"10.1200","volume":"41","author":[{"given":"Kim Robyn","family":"Kennedy","sequence":"first","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daren Joseph","family":"Gibson","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Flukes","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra Sai","family":"Diwakarla","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa Jane","family":"Spalding","sequence":"additional","affiliation":[{"name":"University of Western Australia, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew David","family":"Redfern","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","container-title":["Journal of Clinical Oncology"],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2023.41.16_suppl.e18027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T16:04:36Z","timestamp":1685894676000},"score":7.5874124,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2023.41.16_suppl.e18027"}},"issued":{"date-parts":[[2023,6,1]]},"references-count":0,"journal-issue":{"issue":"16_suppl","published-print":{"date-parts":[[2023,6,1]]}},"alternative-id":["10.1200\/JCO.2023.41.16_suppl.e18027"],"URL":"https:\/\/doi.org\/10.1200\/jco.2023.41.16_suppl.e18027","ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"published":{"date-parts":[[2023,6,1]]},"assertion":[{"value":"2023-05-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:21:42Z","timestamp":1777414902381,"version":"3.51.4"},"reference-count":64,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Australasian Marketing Journal"],"published-print":{"date-parts":[[2022,11]]},"abstract":"Market share growth requires building mental and physical availability among all category buyers. However, if younger category buyers are more likely to purchase new-to-market products, then perhaps younger buyers are, relatively speaking, more important for growth. This research investigates the relationship between category buyer age, brand buyer age, and brand failure. When sub-brand buyer age is younger than category buyer age, the sub-brand is likely to be (a) new-to-market or (b) growing in market share. Older-than-category sub-brand-buyer age is likely for sub-brands that are (a) declining or (b) dead. Results from 17\u2009years (1998\u20132014) of U.K. household panel data, including 5,913 sub-brands from 101 categories, show that age skews were uncommon (only 18% of sub-brands), and second, that growing, stable and declining sub-brands appealed equally to all ages. Finally, we identified that new launches and dead brands tend to skew to younger consumers, suggesting that new launches need to appeal to all ages to avoid failure.<\/jats:p>","DOI":"10.1177\/18393349211017316","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T16:24:17Z","timestamp":1622305457000},"page":"364-370","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Ageism Kills Brands"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-4628","authenticated-orcid":false,"given":"Zachary William","family":"Anesbury","sequence":"first","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0085-2014","authenticated-orcid":false,"given":"Steven","family":"Bellman","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Driesener","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7864-2236","authenticated-orcid":false,"given":"Bill","family":"Page","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byron","family":"Sharp","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"bibr1-18393349211017316","doi-asserted-by":"publisher","DOI":"10.2501\/S1470785309201387"},{"key":"bibr2-18393349211017316","doi-asserted-by":"publisher","DOI":"10.1108\/EJM-04-2017-0285"},{"key":"bibr3-18393349211017316","doi-asserted-by":"publisher","DOI":"10.1016\/j.ausmj.2010.11.010"},{"key":"bibr4-18393349211017316","doi-asserted-by":"publisher","DOI":"10.1080\/0267257X.2010.481177"},{"key":"bibr5-18393349211017316","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-5885.2012.01009.x"},{"issue":"1","key":"bibr6-18393349211017316","first-page":"383","volume":"10","author":"Cattin P.","year":"1983","journal-title":"Advances in Consumer Research"},{"issue":"3","key":"bibr7-18393349211017316","first-page":"771","volume":"5","author":"Cierpicki S.","year":"2000","journal-title":"Journal of Empirical Generalisations in Marketing Science"},{"key":"bibr8-18393349211017316","doi-asserted-by":"publisher","DOI":"10.1086\/209341"},{"key":"bibr9-18393349211017316","doi-asserted-by":"publisher","DOI":"10.2501\/S0021849907070109"},{"key":"bibr10-18393349211017316","doi-asserted-by":"publisher","DOI":"10.1108\/EJM-02-2016-0096"},{"key":"bibr11-18393349211017316","volume-title":"Sub-brands: How much substitution occurs between them, and is combined brand penetration lowered as a result?","author":"Dawes J.","year":"2017"},{"key":"bibr12-18393349211017316","doi-asserted-by":"publisher","DOI":"10.1016\/j.ausmj.2020.01.006"},{"key":"bibr13-18393349211017316","doi-asserted-by":"publisher","DOI":"10.1002\/cb.1595"},{"key":"bibr14-18393349211017316","doi-asserted-by":"publisher","DOI":"10.1080\/0267257X.2015.1128961"},{"issue":"3","key":"bibr15-18393349211017316","volume":"14","author":"Dekimpe M. 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Review of Respiratory Medicine"],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17476348.2017.1251844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T20:03:07Z","timestamp":1599422587000},"score":7.587043,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17476348.2017.1251844"}},"issued":{"date-parts":[[2016,11,7]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1,2]]}},"alternative-id":["10.1080\/17476348.2017.1251844"],"URL":"https:\/\/doi.org\/10.1080\/17476348.2017.1251844","ISSN":["1747-6348","1747-6356"],"issn-type":[{"value":"1747-6348","type":"print"},{"value":"1747-6356","type":"electronic"}],"published":{"date-parts":[[2016,11,7]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & 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multidisciplinary team that was created to implement delirium management guidelines and monitor compliance. Audit 1 focused on antipsychotic use in patients aged 66\u2009years and older. Audit 2 reviewed delirium care in the Acute Medical Ward. Audit 3 included ethnographic data and investigated the use of non\u2010pharmacological methods to prevent and manage delirium in the Geriatric Ward. Two years on, Audit 4 is a repeat of Audit 1.<\/jats:p><\/jats:sec>Results<\/jats:title>There were improved rates of cognitive screening between Audits 2 and 3 from 65% n<\/jats:italic>\u2009=\u200940 to 86% n<\/jats:italic>\u2009=\u2009102, respectively. Most patients had one form of non\u2010pharmacological strategy in place to prevent delirium however few had a multicomponent approach. Fewer patients were prescribed benzodiazepines alongside antipsychotics 28.57% n<\/jats:italic>\u2009=\u200935 in Audit 1 compared to Audit 4 12.5% n<\/jats:italic>\u2009=\u200932.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Improved quality of care in delirium management is achievable via a co\u2010ordinated multidisciplinary approach. These audits demonstrated improvements in both rates of cognitive screening, and use of non\u2010pharmacological strategies prior to antipsychotic medication use and better adherence to guidelines for antipsychotic prescribing. Areas for further development in delirium prevention include the uptake of screening and individualised non\u2010pharmacological strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajag.13266","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T02:56:12Z","timestamp":1707274572000},"page":"175-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment and management of delirium in a tertiary hospital\u2014Improvements in cognitive screening and use of non\u2010pharmacological strategies with a multidisciplinary approach"],"prefix":"10.1111","volume":"43","author":[{"given":"Emily","family":"Clarke","sequence":"first","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellie","family":"Newman","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhu","family":"Dravid","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Ricciardello","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Jones","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Caudle","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Kilshaw","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Hilmi","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3650-0475","authenticated-orcid":false,"given":"Leon","family":"Flicker","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"},{"name":"Western Australian Centre for Health & Ageing, Medical School University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Hospital\u2010Acquired Complications Information Kit","author":"ACSQHC","year":"2018"},{"issue":"3","key":"e_1_2_10_3_1","article-title":"Interventions for preventing delirium in hospitalised non\u2010ICU patients","volume":"3","author":"Siddiqi N","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"e_1_2_10_4_1","article-title":"Interventions for preventing delirium in older people in institutional long\u2010term care","volume":"4","author":"Woodhouse R","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_5_1","volume-title":"Delirium Clinical Care Standard","author":"ACSQHC","year":"2016"},{"key":"e_1_2_10_6_1","unstructured":"World Health Organization.ICD\u201010: international statistical classification of diseases and related health problems: tenth revision 2004. 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In World Economic Forum."},{"key":"e_1_3_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/info8040137"}],"event":{"name":"CIKM '18: The 27th ACM International Conference on Information and Knowledge Management","location":"Torino Italy","acronym":"CIKM '18","sponsor":["SIGWEB ACM Special Interest Group on Hypertext, Hypermedia, and Web","SIGIR ACM Special Interest Group on Information Retrieval"]},"container-title":["Proceedings of the 27th ACM International Conference on Information and Knowledge Management"],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3269206.3269222","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3269206.3269222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:44:20Z","timestamp":1750207460000},"score":7.5870247,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3269206.3269222"}},"issued":{"date-parts":[[2018,10,17]]},"references-count":5,"alternative-id":["10.1145\/3269206.3269222","10.1145\/3269206"],"URL":"https:\/\/doi.org\/10.1145\/3269206.3269222","published":{"date-parts":[[2018,10,17]]},"assertion":[{"value":"2018-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:17:03Z","timestamp":1782443823825,"version":"3.54.5"},"reference-count":74,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Mental Health Nurs"],"published-print":{"date-parts":[[2024,10]]},"abstract":"Abstract<\/jats:title>Inclusion of service users in the design and delivery of mental health services is clearly articulated throughout Australian mental health action plans and stated as an expectation within contemporary mental health policy. International and local Australian research demonstrates benefits for the inclusion of lived experience workers in service users' recovery journey; however, persistent challenges and barriers limit their effective integration into transdisciplinary mental health service teams. Non\u2010lived experience workers who actively advocate and champion the inclusion of lived experience or peer workers, known as allies, are acknowledged and recognised as enablers for effective integration of peer workers to service teams. In this discursive paper, authors present recommendations for further development of allyship roles within leadership positions of mental health organisations in Australia. Leaders are in a position to influence the allocation of resources, redress power inequalities and facilitate opportunities for the inclusion of lived experience expertise across all levels of mental health organisations. 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United Nations Conference on Trade and Development."},{"key":"e_1_2_12_41_1","volume-title":"Global financial development report 2019\/2020: Bank regulation and supervision a decade after the global financial crisis","author":"World Bank","year":"2019"},{"key":"e_1_2_12_42_1","volume-title":"The World Bank","author":"World Development Indicators","year":"2022"}],"container-title":["The World Economy"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/twec.13451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T14:02:49Z","timestamp":1707314569000},"score":7.586949,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/twec.13451"}},"issued":{"date-parts":[[2023,6,23]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/twec.13451"],"URL":"https:\/\/doi.org\/10.1111\/twec.13451","archive":["Portico"],"ISSN":["0378-5920","1467-9701"],"issn-type":[{"value":"0378-5920","type":"print"},{"value":"1467-9701","type":"electronic"}],"published":{"date-parts":[[2023,6,23]]},"assertion":[{"value":"2022-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:49:54Z","timestamp":1768585794207,"version":"3.49.0"},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2025,3]]},"abstract":"Summary<\/jats:title>Coronary computed tomography angiography (CCTA) is a well\u2010established and reliable non\u2010invasive imaging modality that provides a comprehensive assessment of coronary artery anatomy and luminal stenosis due to atherosclerosis. Owing to advances in CCTA software and technology, the composition and morphology of coronary plaque can be accurately evaluated. Adverse features which identify plaque as being high\u2010risk or \u2018vulnerable\u2019 can provide a personalised cardiovascular risk assessment over and above stenosis severity. High\u2010risk plaque features on CCTA include spotty calcification, low attenuation plaque, positive remodelling and the napkin ring sign. However, it can be challenging to characterise high\u2010risk plaque accurately on CCTA, and as such, education and experience are required. In this pictorial essay, a comprehensive visual guide to high\u2010risk plaque features on CCTA is provided, with clear examples and challenging cases that highlight common pitfalls. It is important for expert readers to properly identify these features given their association with adverse outcomes and potential future implications on intensive goal\u2010directed medical therapy.<\/jats:p>","DOI":"10.1111\/1754-9485.13817","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T05:29:30Z","timestamp":1734067770000},"page":"206-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characterising high\u2010risk plaque on cardiac CT<\/scp>"],"prefix":"10.1111","volume":"69","author":[{"given":"Abdul Rahman","family":"Ihdayhid","sequence":"first","affiliation":[{"name":"Fiona Stanley Hospital Perth Western Australia Australia"},{"name":"Artrya Ltd Perth Western Australia Australia"},{"name":"Harry Perkins Institute of Medical Research Perth Western Australia Australia"},{"name":"Curtin University Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amro","family":"Sehly","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7222-7314","authenticated-orcid":false,"given":"Nick S R","family":"Lan","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Denston","sequence":"additional","affiliation":[{"name":"Artrya Ltd Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J W","family":"Chow","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E","family":"Newby","sequence":"additional","affiliation":[{"name":"The University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle C","family":"Williams","sequence":"additional","affiliation":[{"name":"The University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0717-740X","authenticated-orcid":false,"given":"Girish","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Perth Western Australia Australia"},{"name":"Artrya Ltd Perth Western Australia Australia"},{"name":"Harry Perkins Institute of Medical Research Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.06.076"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.068"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.10.066"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2020.11.002"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.08.024"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2023.06.703"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.13817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T08:32:06Z","timestamp":1744619526000},"score":7.5868974,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.13817"}},"issued":{"date-parts":[[2024,12,12]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/1754-9485.13817"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.13817","archive":["Portico"],"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"published":{"date-parts":[[2024,12,12]]},"assertion":[{"value":"2024-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:41:42Z","timestamp":1651210902454},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.juro.2016.02.2909","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T07:30:40Z","timestamp":1459150240000},"source":"Crossref","is-referenced-by-count":0,"title":["PD10-01 THE USE OF PORTABLE VIDEO MEDIA VERSUS STANDARD VERBAL COMMUNICATION IN THE UROLOGICAL CONSENT PROCESS: A RANDOMISED CONTROLLED CLINICAL TRIAL"],"prefix":"10.1097","volume":"195","author":[{"given":"Matthew","family":"Winter","sequence":"first","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Kam","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Hardy","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunny","family":"Nalavenkata","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Handmer","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Ainsworth","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don","family":"Lee","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Louie-Johnsun","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534716031979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534716031979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2016.02.2909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:13:24Z","timestamp":1651209204000},"score":7.5868416,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2016.02.2909"}},"issued":{"date-parts":[[2016,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1016\/j.juro.2016.02.2909"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2016.02.2909","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2016,4]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:40:22Z","timestamp":1753890022937,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Objective: This systematic review aimed to establish a specific evidence-base of diabetes prevention programs for adults at high risk of developing type 2 diabetes (T2D) based on either the Diabetes Prevention Program (DPP) or the Finnish Diabetes Prevention Study (DPS).<\/jats:p>\n Methods: The bibliographic databases: Medline, Ovid, Embase, CINAHL, Scopus, Web of Science, Joanna Brigg Institute Library, Cochrane Central Register of Controlled Trials, and grey literature were searched for published articles in the English language from January 1996 to December 2018. This review included only RCTs conducted in community settings focusing on adults at high risk of T2D, utilizing an intervention based on either the DPP or DPS and measuring the incidence of T2D as an outcome.<\/jats:p>\n Results: Of 4,964 identified records, eight studies met all inclusion criteria and were suitable for meta-analysis. The meta-analysis revealed positive effects of programs based on either DPP or DPS on prevention T2D in adults at high risk. The pooled incidence rate of T2D in the intervention group was 47% lower than those in the control group (95% CI 9%, 69%). Attending lifestyle change program achieved a pooled mean weight loss of 2.10 kg (95% CI -3.45, -0.74) which was significantly higher than those of the control group. Data in physical activity, dietary and HbA1c were not commonly reported. Although the feasibility of the prevention program was established, this review found a lack of data in enablers and barriers in implementing a diabetes prevention program.<\/jats:p>\n Conclusion: The effectiveness of T2D prevention program based on either the DPP or DPS delivered in community settings is evidenced, and the reduction in cumulative incidence of T2D was reported. Nonetheless, further research on enables and barriers associated with increasing physical activity and improving healthy eating is warranted to help sustain the optimal outcomes of the pragmatic diabetes prevention program.<\/jats:p>\n \n Disclosure<\/jats:title>\n K.H. Wechkunanukul: None. F. Benton: None. J. McGill: None. S. Ullah: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-902-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T03:38:22Z","timestamp":1559705902000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["902-P: Effectiveness of Evidence-Based Diabetes Prevention Program in Adults at High Risk of Developing Type 2 Diabetes: A Systematic Review and Meta-analysis"],"prefix":"10.2337","volume":"68","author":[{"given":"KANNIKAR H.","family":"WECHKUNANUKUL","sequence":"first","affiliation":[{"name":"Hilton, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FIONA","family":"BENTON","sequence":"additional","affiliation":[{"name":"Hilton, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOSEPHINE","family":"MCGILL","sequence":"additional","affiliation":[{"name":"Hilton, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHAHID","family":"ULLAH","sequence":"additional","affiliation":[{"name":"Hilton, Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/902-P\/58367\/902-P-Effectiveness-of-Evidence-Based-Diabetes","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/902-P\/58367\/902-P-Effectiveness-of-Evidence-Based-Diabetes","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:10:13Z","timestamp":1647166213000},"score":7.5868416,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/902-P\/58367\/902-P-Effectiveness-of-Evidence-Based-Diabetes"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-902-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"902-P"},{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T17:04:40Z","timestamp":1758992680084,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Background: There are limited contemporary data on the prevalence and progression of diabetic retinopathy (DR) in urban-dwelling Aboriginal Australians. We therefore compared the prevalence of DR and cumulative incidence of new\/worsening DR (NWDR) between Aboriginal and Anglo-Celt Australians with type 2 diabetes (T2D) in the representative community-based Fremantle Diabetes Study Phase II (FDS2).<\/jats:p>\n Methods: From 2008 to 2011, 932 Anglo-Celt and Aboriginal FDS2 participants with T2D underwent comprehensive baseline assessments and were invited to biennial reviews. Ethnic status was based on self-selection, country\/countries of birth and parents\u2019 birth, language(s) spoken at home, and country of grandparents\u2019 birth. Fundus photographs were graded according to the Early Treatment Diabetic Retinopathy Study protocol. Prevalence of DR and cumulative incidence of NWDR for each ethnic group, and unadjusted and adjusted odds ratios (ORs), were calculated.<\/jats:p>\n Results: Baseline DR data was available for 911 (97.7%) participants (mean age 66.0 years, median T2D duration 8.4 years, 49.7% males). There were 817 Anglo-Celt and 94 Aboriginal participants. Of these, 56% had follow-up data. Baseline prevalence of any DR was 33.0% in Anglo-Celts and 52.1% in Aboriginals (P&lt;0.001). During 4.2\u00b10.4 years\u2019 follow-up, the cumulative incidence of NWDR was 6.7% and 23.5%, respectively (P&lt;0.001). The unadjusted OR (95% CI) for Aboriginals for any DR and NWDR were 2.21 (1.43-3.39) and 4.32 (1.33-13.98), respectively. These ORs were attenuated after age and sex adjustment (1.21 (1.10-1.33) and 4.1 (1.2-14.1), respectively) but were no longer significant after adjusting for other DR risk factors including HbA1c and systolic blood pressure.<\/jats:p>\n Conclusions: Urban dwelling Aboriginal Australians have substantial DR prevalence and progression, highlighting the need for better access to culturally appropriate management.<\/jats:p>\n \n Disclosure<\/jats:title>\n J.J. Drinkwater: None. W.A. Davis: Advisory Panel; Spouse\/Partner; Lilly Diabetes, Merck Sharp & Dohme Corp., Novo Nordisk A\/S. Speaker\u2019s Bureau; Self; Boehringer Ingelheim International GmbH. Speaker\u2019s Bureau; Spouse\/Partner; Lilly Diabetes, Merck Sharp & Dohme Corp., Mylan, Novo Nordisk A\/S, Sanofi-Aventis. Other Relationship; Self; Proteomics International. Other Relationship; Spouse\/Partner; Proteomics International. A.W. Turner: None. T. Davis: Advisory Panel; Self; Lilly Diabetes, Merck Sharp & Dohme Corp., Novo Nordisk A\/S. Speaker\u2019s Bureau; Spouse\/Partner; Boehringer Ingelheim International GmbH. Speaker\u2019s Bureau; Self; Lilly Diabetes, Merck Sharp & Dohme Corp., Mylan, Novo Nordisk A\/S, Sanofi-Aventis. Other Relationship; Self; Protemics International. Other Relationship; Spouse\/Partner; Protemics International.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n University of Western Australia; Australian Government Training Program; National Health and Medical Research Council of Australia<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-564-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:52Z","timestamp":1592238592000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["564-P: Differences in Diabetic Retinopathy Prevalence and Progression between Aboriginal and Anglo-Celt Australians: The Fremantle Diabetes Study Phase II"],"prefix":"10.2337","volume":"69","author":[{"given":"JOCELYN J.","family":"DRINKWATER","sequence":"first","affiliation":[{"name":"Fremantle, Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WENDY A.","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Fremantle, Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANGUS W.","family":"TURNER","sequence":"additional","affiliation":[{"name":"Fremantle, Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIMOTHY","family":"DAVIS","sequence":"additional","affiliation":[{"name":"Fremantle, Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/564-P\/57959\/564-P-Differences-in-Diabetic-Retinopathy","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/564-P\/57959\/564-P-Differences-in-Diabetic-Retinopathy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:46:59Z","timestamp":1647164819000},"score":7.5868416,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/564-P\/57959\/564-P-Differences-in-Diabetic-Retinopathy"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-564-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"564-P"},{"indexed":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T17:14:36Z","timestamp":1656522876281},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"4_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2012,2,6]]},"abstract":"Abstract<\/jats:title>\n The ETS1 transcription factor is overexpressed in human prostate cancers in comparison to nonmalignant prostate and exhibits nuclear, in addition to aberrant cytoplasmic localisation. A previous report has identified direct interaction between ETS1 and the androgen receptor (AR) in the prostate cancer cell line, LNCaP and we have demonstrated that this ligand-dependent interaction is mediated via the ETS (DNA binding) domain of ETS1 and the ligand-binding domain of the AR. In a cohort of 44 prostate cancer cases, mRNA for the full-length ETS1 isoform, p54ETS1 was detected in all prostate tumour and adjacent nonmalignant prostate tissues, while expression of the internally truncated p42ETS1 isoform was very low or undetectable. In protein lysates extracted from the same cases, p54ETS1 was detected in all samples, with expression of a lower molecular weight ETS1 corresponding in size to the dominant negative p27ETS1 isoform also observed. Increased expression of one or both of the ETS1 isoforms was identified in 38 (86%) cases, supporting the elevated expression of ETS1 in human prostate tumours. Both ETS1 and the AR upregulate expression of the prostatic tumour suppressor, NKX3.1 via sequences located in the 5\u2032 promoter and 3\u2032 untranslated region (3\u2032UTR), respectively. Although unresponsive to androgens, the proximal \u223c2kb of the NKX3.1 promoter, and in particular a 76bp sequence surrounding the ETS binding site (EBS) become androgen responsive following ETS1 overexpression. In addition, in LNCaP cells that stably overexpress p54ETS1, the biphasic proliferative responses to androgens, where low (\u226410\u221210M) DHT concentrations stimulate proliferation and higher (&gt;10\u221210M) DHT levels inhibit proliferation, were altered and DHT concentrations as low as 10\u221212M inhibited proliferation. The findings indicate that the increased expression of ETS1 commonly observed in human prostate tumours may modify the androgen responsiveness of the cancer cells, augmenting AR-mediated regulation of androgen target genes and potentially sensitising prostate cancer cells to the very low androgen levels in men treated with androgen ablation therapies.<\/jats:p>\n Citation Format: Jacqueline M. Bentel, Jennet Harvey, Marc A. Thomas, Jamie J. Rodgers, Ebony J. Rouse, Darren M. Preece, Siaw M. Chai, Michael R. Epis, Ronald J. Cohen, Peter J. Leedman, Kimberley Roehrig. ETS1 overexpression in prostate cancer cells [abstract]. In: Proceedings of the AACR Special Conference on Advances in Prostate Cancer Research; 2012 Feb 6-9; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2012;72(4 Suppl):Abstract nr B7.<\/jats:p>","DOI":"10.1158\/1538-7445.prca2012-b7","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T18:50:37Z","timestamp":1368125437000},"page":"B7-B7","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract B7: ETS1 overexpression in prostate cancer cells"],"prefix":"10.1158","volume":"72","author":[{"given":"Jacqueline M.","family":"Bentel","sequence":"first","affiliation":[{"name":"1Royal Perth Hospital, Perth, Australia, 2University of Western Australia, Perth, Australia, 3PathWest Laboratory Medicine, Perth, Australia, 4Western Australian Institute for Medical Research, Perth, Australia, 5Uropath, West Leederville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennet","family":"Harvey","sequence":"additional","affiliation":[{"name":"1Royal Perth Hospital, Perth, Australia, 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These include climate\u2010driven range shifts and gene flow mediated by biogeographical influences on dispersal. Assessments that integrate these drivers are uncommon, but critical for testing biogeographic hypotheses. Here, we characterize intraspecific genetic diversity and spatial structure across the entire distribution of a temperate seagrass to test marine biogeographic concepts for southern Australia. Predictive modeling was used to contrast the current Posidonia australis<\/jats:italic> distribution to its historical distribution during the Last Glacial Maximum (LGM). Spatial genetic structure was estimated for 44 sampled meadows from across the geographical range of the species using nine microsatellite loci. Historical and contemporary distributions were similar, with the exception of the Bass Strait. Genetic clustering was consistent with the three currently recognized biogeographic provinces and largely consistent with the finer\u2010scale IMCRA bioregions. Discrepancies were found within the Flindersian province and southwest IMCRA bioregion, while two regions of admixture coincided with transitional IMCRA bioregions. Clonal diversity was highly variable but positively associated with latitude. Genetic differentiation among meadows was significantly associated with oceanographic distance. Our approach suggests how shared seascape drivers have influenced the capacity of P. australis<\/jats:italic> to effectively track sea level changes associated with natural climate cycles over millennia, and in particular, the recolonization of meadows across the Continental Shelf following the LGM. Genetic structure associated with IMCRA bioregions reflects the presence of stable biogeographic barriers, such as oceanic upwellings. This study highlights the importance of biogeography to infer the role of historical drivers in shaping extant diversity and structure.<\/jats:p>","DOI":"10.1002\/ece3.9900","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T03:20:13Z","timestamp":1679282413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Historic and contemporary biogeographic perspectives on range\u2010wide spatial genetic structure in a widespread seagrass"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5789-8945","authenticated-orcid":false,"given":"Elizabeth A.","family":"Sinclair","sequence":"first","affiliation":[{"name":"School of Biological Sciences University of Western Australia Crawley Western Australia Australia"},{"name":"Oceans Institute, University of Western Australia Crawley Western Australia Australia"},{"name":"Kings Park Science, Department of 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Laboratories testing routine patients' samples collected 100 samples that gave anti-rubella virus IgG results of 40 IU\/ml or less from each of five different commercial immunoassays (CIA). The total of 500 quantitative results obtained from 100 samples from each CIA were compared with results obtained from an in-house enzyme immunoassay (IH-EIA) calibrated using the WHO standard. All 500 samples were screened using a hemagglutination inhibition assay (HAI). Any sample having an HAI titer of 1:8 or less was assigned a negative anti-rubella virus antibody status. If the HAI titer was greater than 1:8, the sample was tested in an immunoblot (IB) assay. If the IB result was negative, the sample was assigned a negative anti-rubella virus IgG status; otherwise, the sample was assigned a positive status. Concordance between the CIA qualitative results and the assigned negative status ranged from 50.0 to 93.8% and 74.5 to 97.8% for the assigned positive status. Using a receiver operating characteristic analysis with the cutoff set at 10 IU\/ml, the estimated sensitivity and specificity ranged from 70.2 to 91.2% and 65.9 to 100%, respectively. There was poor correlation between the quantitative CIA results and those obtained by the IH-EIA, with the coefficient of determination (\n R<\/jats:italic>\n 2<\/jats:sup>\n ) ranging from 0.002 to 0.413. Although CIAs have been calibrated with the same international standard for more than 2 decades, the level of standardization continues to be poor. It may be time for the scientific community to reevaluate the relevance of quantification of anti-rubella virus IgG.\n <\/jats:p>","DOI":"10.1128\/cvi.00603-12","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T11:17:30Z","timestamp":1356002250000},"page":"255-261","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Investigation into Low-Level Anti-Rubella Virus IgG Results Reported by Commercial Immunoassays"],"prefix":"10.1128","volume":"20","author":[{"given":"Wayne","family":"Dimech","sequence":"first","affiliation":[{"name":"NRL, Melbourne Australia, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilukshi","family":"Arachchi","sequence":"additional","affiliation":[{"name":"NRL, Melbourne Australia, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Cai","sequence":"additional","affiliation":[{"name":"NRL, Melbourne Australia, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri","family":"Sahin","sequence":"additional","affiliation":[{"name":"NRL, Melbourne Australia, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Wilson","sequence":"additional","affiliation":[{"name":"NRL, Melbourne Australia, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"267","article-title":"Congenital cataract following German measles in the mother","volume":"19","author":"Gregg NM","year":"1991","unstructured":"GreggNM. 1991. 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Golledge","sequence":"additional","affiliation":[{"name":"James Cook University, Townsville, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Norman","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Beilby","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine, Perth, , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2019,4,30]]},"container-title":["Journal of the Endocrine 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Using conversation analysis, we analysed a collection of 100 cases of callers saying \u2018\n I think<\/jats:italic>\n \u2019 or \u2018\n I don\u2019t think<\/jats:italic>\n \u2019 in emergency calls for cardiac arrest in Australia. Callers do not typically express uncertainty when they say \u2018\n I (don\u2019t) think<\/jats:italic>\n \u2019, but rather, use \u2018\n I (don\u2019t) think<\/jats:italic>\n \u2019 as an epistemic stance marker introducing their own perspective and indexing low epistemic status. However, call-takers often orient to \u2018\n I (don\u2019t) think<\/jats:italic>\n \u2019 as signalling uncertainty (about accuracy of patient assessment) and subsequently request verification. These requests can create unnecessary delays, as we show that callers who said \u2018\n I (don\u2019t) think<\/jats:italic>\n \u2019 rarely changed their initial assessment. We describe how these findings can be translated into practical recommendations for call-taker training, so as to improve emergency medical dispatch for time-critical situations.\n <\/jats:p>","DOI":"10.1177\/14614456251332813","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T11:18:43Z","timestamp":1746098323000},"page":"98-116","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["\u2018You don\u2019t think? But you can check\u2019: Do emergency callers really express uncertainty when they say \u2018I (don\u2019t) think\u2019?"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9703-5239","authenticated-orcid":false,"given":"Marine","family":"Riou","sequence":"first","affiliation":[{"name":"Universit\u00e9 Lumi\u00e8re Lyon 2, France"},{"name":"Institut Universitaire de France, France"},{"name":"Curtin University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirukshi","family":"Perera","sequence":"additional","affiliation":[{"name":"Curtin University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Ball","sequence":"additional","affiliation":[{"name":"Curtin University, Australia"},{"name":"St John Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin","family":"Whiteside","sequence":"additional","affiliation":[{"name":"St John Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Finn","sequence":"additional","affiliation":[{"name":"Curtin University, Australia"},{"name":"St John Western Australia, Australia"},{"name":"Monash University, Australia"},{"name":"The University of Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/9783110889932.1"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2023.110104"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10439463.2024.2386282"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.33151\/ajp.18.858"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/9781139022767"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/08351813.2015.1058606"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1075\/ds.25.07fel"},{"key":"e_1_3_5_9_1","first-page":"89","volume-title":"Les Interactions Asym\u00e9triques","author":"Filliettaz L","year":"2006","unstructured":"Filliettaz L (2006) Asym\u00e9trie et prises de r\u00f4les. Le cas des r\u00e9clamations dans les interactions de service. In: Laforest M, Vincent D (eds) Les Interactions Asym\u00e9triques. Qu\u00e9bec: Nota Bene, pp.89\u2013112."},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005058"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2016.09.027"},{"key":"e_1_3_5_12_1","first-page":"370","volume-title":"The Handbook of Conversation Analysis","author":"Heritage J","year":"2013","unstructured":"Heritage J (2013) Epistemics in conversation. In: Sidnell J, Stivers T (eds) The Handbook of Conversation Analysis. Chichester: Wiley-Blackwell, pp.370\u2013394."},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pragma.2015.08.008"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/019027250506800103"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781139045414.013"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1075\/pbns.125.02jef"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1075\/pbns.115"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pragma.2015.01.005"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/08351813.2024.2305048"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-682X.1980.tb00020.x"},{"key":"e_1_3_5_21_1","volume-title":"Medical Priority Dispatch System (version 13.1)","author":"Priority Dispatch Corp","year":"2018","unstructured":"Priority Dispatch Corp (2018) Medical Priority Dispatch System (version 13.1). Salt Lake City, UT: Priority Dispatch Corp."},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2021.01.001"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016510"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2017.11.058"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2020.113045"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.3917\/ls.179.0034"},{"key":"e_1_3_5_27_1","volume-title":"The Handbook of Conversation Analysis","author":"Sidnell J","year":"2013","unstructured":"Sidnell J, Stivers T (eds) (2013) The Handbook of Conversation Analysis. Chichester: Wiley Blackwell."},{"issue":"1","key":"e_1_3_5_28_1","first-page":"41","article-title":"The functions of","volume":"10","author":"Simon-Vandenbergen A-M","year":"2000","unstructured":"Simon-Vandenbergen A-M (2000) The functions of I think in political discourse. International Journal of Applied Linguistics 10(1): 41\u201363.","journal-title":"I think"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780197563892.001.0001"},{"key":"e_1_3_5_30_1","first-page":"313","volume-title":"Grammaticalization II","author":"Thompson S","year":"1991","unstructured":"Thompson S, Mulac A (1991) A quantitative perspective on the grammaticization of epistemic parentheticals in English. In: Traugott EC, Heine B (eds) Grammaticalization II. Amsterdam: John Benjamins, pp.313\u2013339."}],"container-title":["Discourse Studies"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14614456251332813","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14614456251332813","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14614456251332813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:59:03Z","timestamp":1777399143000},"score":7.585676,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/14614456251332813"}},"issued":{"date-parts":[[2025,5]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1177\/14614456251332813"],"URL":"https:\/\/doi.org\/10.1177\/14614456251332813","ISSN":["1461-4456","1461-7080"],"issn-type":[{"value":"1461-4456","type":"print"},{"value":"1461-7080","type":"electronic"}],"published":{"date-parts":[[2025,5]]}},{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:50:30Z","timestamp":1783734630940,"version":"3.55.0"},"reference-count":58,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T00:00:00Z","timestamp":1485734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1021988"],"award-info":[{"award-number":["APP1021988"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Health (London)"],"published-print":{"date-parts":[[2017,5]]},"abstract":"For over 20\u2009years, drug policy experts have been calling for the wider availability of naloxone, to enable lay overdose witnesses to respond to opioid overdose events. However, the \u2018evidence base\u2019 for peer-administered naloxone has become a key point of contention. This contention opens up critical questions about how knowledge (\u2018evidence\u2019) is constituted and validated in drug policy processes, which voices may be heard, and how knowledge producers secure privileged positions of influence. Taking the debate surrounding peer-administered naloxone as a case study, and drawing on qualitative interviews with individuals (n\u2009=\u200919) involved in the development of naloxone policy in Australia, we examine how particular kinds of knowledge are rendered \u2018useful\u2019 in drug policy debates. Applying Bacchi\u2019s poststructuralist approach to policy analysis, we argue that taken-for-granted \u2018truths\u2019 implicit within evidence-based policy discourse privilege particular kinds of \u2018objective\u2019 and \u2018rational\u2019 knowledge and, in so doing, legitimate the voices of researchers and clinicians to the exclusion of others. What appears to be a simple requirement for methodological rigour in the evidence-based policy paradigm actually rests on deeper assumptions which place limits around not only what can be said (in terms of what kind of knowledge is relevant for policy debate) but also who may legitimately speak. However, the accounts offered by participants reveal the ways in which a larger number of ways of knowing are already co-habiting within drug policy. Despite these opportunities for re-problematisation and resistance, the continued mobilisation of \u2018evidence-based\u2019 discourse obscures these contesting positions and continues to privilege particular speakers.<\/jats:p>","DOI":"10.1177\/1363459316688520","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T17:32:45Z","timestamp":1485883965000},"page":"278-294","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":41,"title":["\u2018Naloxone works\u2019: The politics of knowledge in \u2018evidence-based\u2019 drug policy"],"prefix":"10.1177","volume":"21","author":[{"given":"Kari","family":"Lancaster","sequence":"first","affiliation":[{"name":"UNSW Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Treloar","sequence":"additional","affiliation":[{"name":"UNSW Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Ritter","sequence":"additional","affiliation":[{"name":"UNSW Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"bibr1-1363459316688520","volume-title":"Analysing Policy: What\u2019s the Problem Represented to Be?","author":"Bacchi C","year":"2009"},{"key":"bibr2-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1177\/0091450915576116"},{"key":"bibr3-1363459316688520","doi-asserted-by":"publisher","DOI":"10.5172\/hesr.2012.21.3.313"},{"key":"bibr4-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7338.678"},{"key":"bibr5-1363459316688520","doi-asserted-by":"publisher","DOI":"10.3109\/09687637.2014.981509"},{"key":"bibr6-1363459316688520","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-1-201301010-00003"},{"key":"bibr7-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1997.tb03681.x"},{"key":"bibr8-1363459316688520","doi-asserted-by":"publisher","DOI":"10.46692\/9781847425119"},{"key":"bibr9-1363459316688520","volume-title":"Governmentality: Power and Rule in Modern Society","author":"Dean MM","year":"1999"},{"key":"bibr10-1363459316688520","unstructured":"Dietze P, Lenton S (2010) The case for the wider distribution of naloxone in Australia. Available at: http:\/\/www.atoda.org.au\/wp-content\/uploads\/The_heroin_reversal_drug_naloxone_FIN2.pdf (accessed 20 January 2017)."},{"key":"bibr11-1363459316688520","unstructured":"Eurasian Harm Reduction Network (2014) I\u2019m the evidence: Naloxone works! (6 videos). Available at: http:\/\/www.harm-reduction.org\/library\/im-evidence-naloxone-works-6-videos-ehrn-2014 (accessed 20 October 2015)."},{"key":"bibr12-1363459316688520","unstructured":"Eurasian Harm Reduction Network (2015) I\u2019m the evidence. Naloxone works (Facebook page). Available at: https:\/\/www.facebook.com\/NaloxoneWorks (accessed 20 October 2015)."},{"key":"bibr13-1363459316688520","volume-title":"Power\/Knowledge: Selected Interviews and Other Writings 1972\u20131977","author":"Foucault M","year":"1980"},{"key":"bibr14-1363459316688520","first-page":"87","volume-title":"The Foucault Effect: Studies in Governmentality","author":"Foucault M","year":"1991"},{"key":"bibr15-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1177\/0091450915570308"},{"key":"bibr16-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2015.10.014"},{"key":"bibr17-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2011.09.004"},{"key":"bibr18-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1057\/9781137316776"},{"key":"bibr19-1363459316688520","unstructured":"Harm Reduction Coalition (2015) I\u2019m the evidence video campaign. Available at: http:\/\/harmreduction.org\/issue-area\/overdose-prevention-issue-area\/i%E2%80%99m-the-evidence-video\/ (accessed 20 October 2015)."},{"key":"bibr20-1363459316688520","first-page":"121","volume-title":"The New Sociology of the Health Service","author":"Harrison S","year":"2009"},{"key":"bibr21-1363459316688520","volume-title":"Nothing about Us without Us \u2013 Greater, Meaningful Involvement of People Who Use Illegal Drugs: A Public Health, Ethical, and Human Rights Imperative","author":"J\u00fcrgens R","year":"2008"},{"key":"bibr22-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2014.01.002"},{"key":"bibr23-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1177\/0091450916633306"},{"key":"bibr24-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1080\/13645579.2015.1123555"},{"key":"bibr25-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2013.07.002"},{"key":"bibr26-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2014.02.003"},{"key":"bibr27-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2015.04.006"},{"key":"bibr28-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1111\/j.1465-3362.2012.00497.x"},{"key":"bibr29-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2015.05.014"},{"key":"bibr30-1363459316688520","volume-title":"An Inquiry into Modes of Existence","author":"Latour B","year":"2013"},{"key":"bibr31-1363459316688520","doi-asserted-by":"publisher","DOI":"10.4324\/9780203481141"},{"key":"bibr32-1363459316688520","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2000.tb125633.x"},{"key":"bibr33-1363459316688520","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2009.tb02891.x"},{"key":"bibr34-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1111\/j.1465-3362.2009.00125.x"},{"key":"bibr35-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1111\/dar.12198"},{"key":"bibr36-1363459316688520","volume-title":"Evidence-Based Health Policy: Problems and Possibilities","author":"Lin V","year":"2003"},{"key":"bibr37-1363459316688520","doi-asserted-by":"publisher","DOI":"10.3109\/09687637.2012.682232"},{"issue":"3","key":"bibr38-1363459316688520","first-page":"143","volume":"3","author":"Marston G","year":"2003","journal-title":"The Drawing Board: An Australian Review of Public Affairs"},{"key":"bibr39-1363459316688520","unstructured":"N-ALIVE (2014) Update for people who have taken part in the N-ALIVE pilot trial. Available at: http:\/\/www.ctu.mrc.ac.uk\/13391\/13399\/n-alive_update_12.14 (accessed 16 November 2015)."},{"key":"bibr40-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1080\/0968763031000072251"},{"key":"bibr41-1363459316688520","unstructured":"Open Society Foundations (2013) Naloxoneinfo.org. Available at: http:\/\/www.naloxoneinfo.org\/ (accessed 18 June 2013)."},{"key":"bibr42-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2015.12.013"},{"key":"bibr43-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2016.01.002"},{"key":"bibr44-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.lawsocsci.2.081805.105900"},{"key":"bibr45-1363459316688520","doi-asserted-by":"publisher","DOI":"10.3109\/16066359.2013.856886"},{"key":"bibr46-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2014.02.016"},{"key":"bibr47-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7429.1459"},{"key":"bibr48-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1057\/9781137026583"},{"key":"bibr49-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2006.05.025"},{"key":"bibr50-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6835.1127"},{"key":"bibr51-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1007\/s11524-013-9803-1"},{"key":"bibr52-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g6580"},{"key":"bibr53-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7044.1435"},{"key":"bibr54-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.333.7569.614"},{"key":"bibr55-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1999.9421993.x"},{"key":"bibr56-1363459316688520","doi-asserted-by":"publisher","DOI":"10.1177\/0261018309105179"},{"issue":"6","key":"bibr57-1363459316688520","first-page":"101","volume":"61","author":"Wheeler E","year":"2012","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"bibr58-1363459316688520","unstructured":"Wodak A (2013) Should naloxone be used to reduce opioid overdoses? The Conversation, 15 November Available at: https:\/\/theconversation.com\/should-naloxone-be-used-to-reduce-opioid-overdoses-19896"}],"container-title":["Health: An Interdisciplinary Journal for the Social Study of Health, Illness and Medicine"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1363459316688520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1363459316688520","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1363459316688520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:34:55Z","timestamp":1777448095000},"score":7.5853376,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1363459316688520"}},"issued":{"date-parts":[[2017,1,30]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1177\/1363459316688520"],"URL":"https:\/\/doi.org\/10.1177\/1363459316688520","ISSN":["1363-4593","1461-7196"],"issn-type":[{"value":"1363-4593","type":"print"},{"value":"1461-7196","type":"electronic"}],"published":{"date-parts":[[2017,1,30]]}},{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:55:05Z","timestamp":1787496905241,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,6]],"date-time":"2016-11-06T00:00:00Z","timestamp":1478390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and objective<\/jats:title>\n \n Immunosuppression therapy following lung transplantation fails to prevent chronic rejection in many patients, which is associated with lack of suppression of cytotoxic mediators and pro\u2010inflammatory cytokines in peripheral blood T and natural killer T (\n NKT<\/jats:styled-content>\n )\u2010like cells. Histone acetyltransferases (\n HATs<\/jats:styled-content>\n ) and histone deacetylases (\n HDACs<\/jats:styled-content>\n ) upregulate\/downregulate pro\u2010inflammatory gene expression, respectively; however, differences in the activity of these enzymes following lung transplant are unknown. We hypothesized decreased HDAC2 expression and increased HAT expression in pro\u2010inflammatory lymphocytes following lung transplant.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Blood was collected from 18 stable lung transplant patients and 10 healthy age\u2010matched controls. Intracellular pro\u2010inflammatory cytokines and\n HAT<\/jats:styled-content>\n \/\n HDAC2<\/jats:styled-content>\n expression were determined in lymphocyte subsets following culture using flow cytometry.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A loss of\n HDAC2<\/jats:styled-content>\n in cluster of differentiation (\n CD<\/jats:styled-content>\n ) 8+ T and\n NKT<\/jats:styled-content>\n \u2010like cells in transplant patients compared with controls was noted (\n CD8<\/jats:styled-content>\n + T: 28 \u00b1 10 (45 \u00b1 10),\n CD8<\/jats:styled-content>\n +\n NKT<\/jats:styled-content>\n \u2010like: 30 \u00b1 13 (54 \u00b1 16) (mean \u00b1\n SD<\/jats:styled-content>\n transplant) (control)). Loss of\n HDAC2<\/jats:styled-content>\n was associated with an increased percentage of\n CD8<\/jats:styled-content>\n + T and\n NKT<\/jats:styled-content>\n \u2010like cells expressing perforin, granzyme b, interferon gamma (\n IFN\u2010\u03b3<\/jats:styled-content>\n ) and\n TNF\u2010\u03b1<\/jats:styled-content>\n (no change in\n HAT<\/jats:styled-content>\n expression in any lymphocyte subset). There was a negative correlation between loss of\n HDAC2<\/jats:styled-content>\n expression by\n CD8<\/jats:styled-content>\n + T cells with cumulative dose of prednisolone and time post\u2010transplant. Treatment with 10 mg\/L theophylline + 1 \u00b5mol\/L prednisolone or 2.5 ng\/\n mL<\/jats:styled-content>\n cyclosporine A synergistically upregulated\n HDAC2<\/jats:styled-content>\n and inhibited\n IFN\u2010\u03b3<\/jats:styled-content>\n and\n TNF\u2010\u03b1<\/jats:styled-content>\n production by\n CD8<\/jats:styled-content>\n + T and\n NKT<\/jats:styled-content>\n \u2010like lymphocytes.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n HDAC2<\/jats:styled-content>\n is decreased in\n CD8<\/jats:styled-content>\n + T and\n NKT<\/jats:styled-content>\n \u2010like pro\u2010inflammatory lymphocytes following lung transplant. Treatment options that increase\n HDAC2<\/jats:styled-content>\n may improve graft survival.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.12933","type":"journal-article","created":{"date-parts":[[2016,11,6]],"date-time":"2016-11-06T20:14:59Z","timestamp":1478463299000},"page":"394-400","source":"Crossref","is-referenced-by-count":7,"title":["Histone deacetylase 2 is decreased in peripheral blood pro\u2010inflammatory\n CD8<\/scp>\n + T and\n NKT<\/scp>\n \u2010like lymphocytes following lung transplant"],"prefix":"10.1111","volume":"22","author":[{"given":"Greg","family":"Hodge","sequence":"first","affiliation":[{"name":"Lung Research Hanson Institute Adelaide South Australia Australia"},{"name":"Department of Thoracic Medicine Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Department of Medicine University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Hodge","sequence":"additional","affiliation":[{"name":"Lung Research Hanson Institute Adelaide South Australia Australia"},{"name":"Department of Thoracic Medicine Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Department of Medicine University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Li","family":"Holmes\u2010Liew","sequence":"additional","affiliation":[{"name":"Lung Research Hanson Institute Adelaide South Australia Australia"},{"name":"Department of Thoracic Medicine Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Department of Medicine University of Adelaide Adelaide South Australia Australia"},{"name":"South Australian Lung Transplant Service Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul N.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Lung Research Hanson Institute Adelaide South Australia Australia"},{"name":"Department of Thoracic Medicine Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Department of Medicine University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Holmes","sequence":"additional","affiliation":[{"name":"Lung Research Hanson Institute Adelaide South Australia Australia"},{"name":"Department of Thoracic Medicine Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Department of Medicine University of Adelaide Adelaide South Australia Australia"},{"name":"South Australian Lung Transplant Service Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.02.032"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02711.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02671.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.02075.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04186.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181d75971"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ac170f"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.04008.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.04.007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00117504"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.05.004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-015-0287-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-85"},{"key":"e_1_2_6_15_1","first-page":"46","article-title":"HDAC inhibitor therapy in autoimmunity and transplantation","volume":"71","author":"Hancock WW","year":"2011","journal-title":"Br. Med. J."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050466"}],"container-title":["Respirology"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.12933","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.12933","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.12933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T15:11:47Z","timestamp":1696000307000},"score":7.585286,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.12933"}},"issued":{"date-parts":[[2016,11,6]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/resp.12933"],"URL":"https:\/\/doi.org\/10.1111\/resp.12933","archive":["Portico"],"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"published":{"date-parts":[[2016,11,6]]}},{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:13:09Z","timestamp":1778505189059,"version":"3.51.4"},"reference-count":39,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"unspecified","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012256","name":"Cerebral Palsy Alliance Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032244","name":"Perth Children\u2019s Hospital Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100032244","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["bmjpo"],"accepted":{"date-parts":[[2026,3,15]]},"published-print":{"date-parts":[[2026,5]]},"abstract":"\n Background<\/jats:title>\n Respiratory disease is a leading cause of hospitalisations in children with cerebral palsy (CP). Over 40% of individuals with CP are born preterm; however, the relationship between prematurity, CP and respiratory disease is unknown.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To establish the impact of gestational age (GA) and bronchopulmonary dysplasia (BPD) on respiratory hospitalisations in children with CP.<\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n A 30-year (1986\u20132015)\u2009retrospective data linkage cohort study in children with CP.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 1915 individuals with CP (mean age 15 years and 5 months, 57% male) recorded 5566 respiratory admissions. Higher rates of respiratory admissions were seen in those born preterm (<37 weeks). Preterm infants with CP and BPD had 4.4 (incidence rate ratio 95%\u2009CI 3.3 to 6.0) times more respiratory-related admissions (after controlling for age, CP severity, epilepsy, speech impairment and gastrostomy) compared with individuals with CP born at term. Preterm infants with CP and BPD had respiratory-related hospitalisations at a younger age (median: 2 years 4 months vs term birth 20 years, p<0.001).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Preterm birth and BPD are risk factors for earlier and higher rates of respiratory-related admissions in individuals with CP. Perinatal and neonatal events should be considered when assessing respiratory health in CP.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjpo-2025-004221","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:40:24Z","timestamp":1778503224000},"page":"e004221","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Respiratory disease in cerebral palsy: the overlooked impact of neonatal lung disease"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9311-4386","authenticated-orcid":false,"given":"Natasha","family":"Bear","sequence":"first","affiliation":[{"name":"School of Allied Health, Curtin University, Perth, Western Australia, Australia"},{"name":"Wal-Yan Respiratory Research Centre, The Kids Research Institute Australia, Nedlands, Western Australia, 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The performance of the 2021 equation in people with diabetes is unknown. This study aims to assess and compare the performance of the 2021 CKD-EPI equation to the 2009 CKD-EPI equation in individuals with type 1 and\/or type 2 diabetes.<\/jats:p>\n Methods: Datapoints (n=16,182) were collected from people with type 1 and type 2 diabetes from six international cohorts (Diabetes Control and Complication Trial [DCCT, USA], Colorado [USA], Germany, Korea, Spain, and Australia), with mGFR assessed using exogenous filtration markers. The intra-class correlation coefficient between mGFR and eGFR for 2009 CKD-EPI equation and 2021 CKD-EPI equation was estimated using (a) a one-step intra-individual participant data meta-analysis approach, and (b) a four-level mixed-effect linear model which included studies and individual participants as first and second level random effects, method of measurement as third level fixed effect and time as fourth level random effect.<\/jats:p>\n Results: Overall performance of the 2009 CKD-EPI equation was excellent (ICC: 0.96, 95%CI: 0.88, 0.99) and 2021 CKD-EPI equations (ICC: 0.87, 95%CI: 0.77, 0.93) was good. However, subgroup analyses based on clinically relevant GFR ranges (&lt;30, 30-59, 60-89 ml\/min\/1.73m2) revealed poor agreement between mGFR and eGFR measurements for the 2009 CKD-EPI equation (ICC: 0.41, 0.43, 0.40 respectively) and excellent agreement for GFR \u226590 ml\/min\/1.73m2 (ICC: 0.92). The 2021 CKD-EPI equation revealed poor agreement across GFR ranges &lt;30, 30-59 and 60-89 (ICC: 0.38, 0.41, 0.39 respectively) and moderate agreement for GFR \u226590 ml\/min\/1.73m2 (ICC: 0.55).<\/jats:p>\n Conclusion: These findings suggest that the 2009 CKD-EPI equation still performs better than the 2021 CKD-EPI equation without the race co-efficient, especially in higher GFR ranges for people with diabetes.<\/jats:p>\n \n Disclosure<\/jats:title>\n R. Kwok: None. R. MacIsaac: None. K. Kishore: None. T. Zafari: None. M. Hachem: None. D. Koye: None. E. Schaeffner: Consultant; AstraZeneca. Other Relationship; National Kidney Foundation. T. Jeong: None. W. Min: None. P. Bjornstad: Consultant; AstraZeneca, Boehringer-Ingelheim. Advisory Panel; Lilly Diabetes, Novo Nordisk, Bayer Inc., Horizon Therapeutics plc. L. Churilov: None. E.I. Ekinci: Advisory Panel; Lilly Diabetes. Research Support; Novo Nordisk, Boehringer-Ingelheim, Eli Lilly and Company. Board Member; Eli Lilly and Company. Advisory Panel; Abbott. Research Support; Endogenex, Versanis, AstraZeneca.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Australian Government Research Training Program (RTP) Scholarship<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db24-410-p","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T06:52:30Z","timestamp":1718347950000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["410-P: Evaluating the Performance of the 2021 CKD\u2013EPI Equation in People with Diabetes"],"prefix":"10.2337","volume":"73","author":[{"given":"RODNEY","family":"KWOK","sequence":"first","affiliation":[{"name":"Fitzroy, Australia, Heidelberg, Australia, Melbourne, Australia, Berlin, Germany, Seoul, Republic of Korea, Aurora, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"MACISAAC","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Heidelberg, Australia, 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Journal of Physiology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Key points<\/jats:title>\nDuring quiet breathing, the muscles of the upper airway of healthy humans contract to dilate the airway during inspiration.<\/jats:p><\/jats:list-item>\nWe used dynamic tagged magnetic resonance imaging to show that the amount of active upper airway dilatation during inspiration increases as airway cross\u2010sectional area decreases.<\/jats:p><\/jats:list-item>\nOlder and more overweight subjects have smaller airways, and this is linked to increased active airway dilatation.<\/jats:p><\/jats:list-item>\nThese data show that healthy subjects with narrow airways can overcome anatomical risk factors for airway collapse by actively dilating their airways during inspiration.<\/jats:p><\/jats:list-item>\nIn contrast, obstructive sleep apnoea patients with similarly narrow airways show either little or no dilatory motion during inspiration or abnormal bi\u2010directional movement. This regulation of airway behaviour fails in these patients.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><\/jats:sec>Abstract<\/jats:title>A patent upper airway is essential for survival. Increased age, obesity and some upper airway anatomical features are associated with failure to maintain upper airway patency during sleep, leading to obstructive sleep apnoea. However, many healthy subjects with these risk factors do not develop this condition. The aim of this study was to determine how anatomical factors and active dilator muscle contraction contribute to upper airway patency in healthy volunteers across a broad range of age and body mass index (BMI). A \u2018tagged\u2019 magnetic resonance imaging technique quantified respiratory\u2010related motion of the anterior and lateral walls of the upper airway during quiet breathing in the supine position. Fifty\u2010two subjects aged 22\u221268\u00a0years with BMI from 17.5 to 40.1\u00a0kg\u00a0m\u22122<\/jats:sup> were studied. Higher BMI was associated with smaller airway cross\u2010sectional area at the level of soft palate (P<\/jats:italic>\u00a0<\u00a00.05). The genioglossus moved anteriorly to dilate the upper airway during inspiration. This movement increased with increasing BMI, increasing age, a smaller airway area, and steeper tongue\u2010base angle (all P<\/jats:italic>\u00a0<\u00a00.05). Motion of the lateral upper airway at the soft\u2010palate level was variable and less strongly linked to anatomical features of the upper airway. Multiple regression indicated that anterior genioglossus motion decreased with increasing airway area (P<\/jats:italic>\u00a0=\u00a00.03) and with increasing tongue\u2010base angle (P<\/jats:italic>\u00a0=\u00a00.02). These data suggest that healthy humans, including those whose anatomy places them at increased risk of airway closure, can maintain upper airway patency by dynamically dilating the airway during inspiration.<\/jats:p><\/jats:sec>","DOI":"10.1113\/jphysiol.2014.279240","type":"journal-article","created":{"date-parts":[[2014,9,13]],"date-time":"2014-09-13T03:26:00Z","timestamp":1410578760000},"page":"4763-4774","source":"Crossref","is-referenced-by-count":49,"title":["Healthy humans with a narrow upper airway maintain patency during quiet breathing by dilating the airway during inspiration"],"prefix":"10.1113","volume":"592","author":[{"given":"Shaokoon","family":"Cheng","sequence":"first","affiliation":[{"name":"Neuroscience Research Australia Sydney Australia"},{"name":"School of Medical Science UNSW Medicine Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Brown","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Hatt","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Butler","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Sydney Australia"},{"name":"School of Medical Science UNSW Medicine Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Gandevia","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Sydney Australia"},{"name":"Prince of Wales Clinical School UNSW Medicine Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne E.","family":"Bilston","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Sydney Australia"},{"name":"Prince of Wales Clinical School UNSW Medicine Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0677h.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2812"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.156430"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00413.2010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00119210"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00159611"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00649.2013"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2653"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.038810"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.266"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(03)00069-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018537"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.02093.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91236.2008"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.5_Pt_1.1228"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1999.1946"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1096-3642.1985.tb01178.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00045.2008"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/138.4.969"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.1.182"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.01.077"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.1.2011065"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09091801"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.6.8665050"},{"key":"e_1_2_6_26_1","unstructured":"NyeE ChengS GandeviaS McKenzieD SinkusR&BilstonL(2011).Measuring the change in mechanical properties of upper airway soft tissues in obstructive sleep apnea using magnetic resonance elastography. 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Assessment reform in the age of artificial intelligence: Discussion paper. https:\/\/www.teqsa.gov.au\/sites\/default\/files\/2023-09\/assessmentreform-age-artificial-intelligence-discussion-paper.pdf"},{"key":"979-8-3373-1195-1.ch011.-46","doi-asserted-by":"publisher","DOI":"10.1186\/s40561-023-00237-x"},{"key":"979-8-3373-1195-1.ch011.-47","doi-asserted-by":"publisher","DOI":"10.1080\/13562517.2024.2362217"},{"key":"979-8-3373-1195-1.ch011.-48","doi-asserted-by":"publisher","DOI":"10.14742\/apubs.2023.514"},{"key":"979-8-3373-1195-1.ch011.-49","doi-asserted-by":"publisher","DOI":"10.14742\/apubs.2024.1408"},{"key":"979-8-3373-1195-1.ch011.-50","doi-asserted-by":"publisher","DOI":"10.5334\/jime.972"},{"key":"979-8-3373-1195-1.ch011.-51","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-19-5587-7_10"},{"key":"979-8-3373-1195-1.ch011.-52","doi-asserted-by":"crossref","unstructured":"Weller, M. (2023). Metaphors of Ed Tech (1st ed). Athabasca University Press.","DOI":"10.15215\/aupress\/9781771993500.01"}],"container-title":["Advances in Computational Intelligence and Robotics","Rethinking Education and Agency in the Age of Human-Generative AI Interaction"],"link":[{"URL":"https:\/\/www.igi-global.com\/viewtitle.aspx?TitleId=392447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:53:16Z","timestamp":1787856796000},"score":7.5843797,"resource":{"primary":{"URL":"https:\/\/services.igi-global.com\/resolvedoi\/resolve.aspx?doi=10.4018\/979-8-3373-1195-1.ch011"}},"subtitle":["Collective Perspectives in Higher Education"],"issued":{"date-parts":[[2025,10,17]]},"ISBN":["9798337311951","9798337311975"],"references-count":52,"URL":"https:\/\/doi.org\/10.4018\/979-8-3373-1195-1.ch011","ISSN":["2327-0411","2327-042X"],"issn-type":[{"value":"2327-0411","type":"print"},{"value":"2327-042X","type":"electronic"}],"published":{"date-parts":[[2025,10,17]]}},{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:22:46Z","timestamp":1740136966073,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aus J Agri &amp; Res Econ"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Traditionally, farms expand by buying out a neighbour. But might remote partnerships be a better way of expanding a farm business given projected climate change and price volatility? This question is addressed using farm business financial modelling. Representative farms at 27 locations in Western Australia are constructed to enable comparison of the value of buying out a neighbour versus expansion using geographically distant joint venture (JV<\/jats:styled-content>) partners. The farm models consider economies of size, bulk purchase price discounts, the variability and correlation of returns associated with farm expansion, and impacts of climate change. Random selection of a remote partner generates little improvement in wealth; on average only 2.3 and 1.6 per cent, respectively, under current and projected future climate across all locations. However, there is large variation in wealth appreciation opportunities for each location and between locations. Preferred partnerships are a function of each farm's characteristics. Locations highly preferred as JV<\/jats:styled-content> partners under current climate are similarly preferred partners under projected future climate. The main sources of additional wealth come from economies of size advantages, risk\u2010spreading benefits of combining geographically separated farms and bulk discounts. Farmers seeking business expansion will often benefit greatly from careful selection of a remote partner.<\/jats:p>","DOI":"10.1111\/1467-8489.12229","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T05:46:36Z","timestamp":1508823996000},"page":"21-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Traditional farm expansion versus joint venture remote partnerships"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0324-9488","authenticated-orcid":false,"given":"Ross","family":"Kingwell","sequence":"first","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"},{"name":"Department of Primary Industries and Regional Development, Western Australia South Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quenten","family":"Thomas","sequence":"additional","affiliation":[{"name":"Quisitive Pty Ltd Innaloo Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Feldman","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imma","family":"Farr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Primary Industries and Regional Development, Western Australia South Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad","family":"Plunkett","sequence":"additional","affiliation":[{"name":"Department of Primary Industries and Regional Development, Western Australia South Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.agsy.2014.09.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4290(03)00154-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/295472"},{"key":"e_1_2_6_5_1","unstructured":"BOM & CSIRO(2015).State of the Climate 2014 Bureau of Meteorology and CSIRO. Available from URLhttp:\/\/www.bom.gov.au\/state-of-the-climate\/"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1257\/0895330042162430"},{"key":"e_1_2_6_7_1","unstructured":"Farr\u00e9 I. Foster I.andCharles S.(2007).Future wheat yields in the West Australian wheatbelt. Paper presented to the Agribusiness Crop Updates Burswood Entertainment Complex Perth WA 14\u201315 February 2007."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1071\/CP16200"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8489.2007.00441.x"},{"key":"e_1_2_6_10_1","first-page":"1","article-title":"How drought affects the financial characteristics of Australian farm businesses","volume":"60","author":"Kingwell R.","year":"2016","journal-title":"Australian Journal of Agricultural and Resource Economics"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","unstructured":"Kingwell R. Anderton L. Islam N. Xayavong V. Wardell\u2010Johnson A. Feldman D.andSpeijers J.(2013).Broadacre farmers adapting to a changing climate. Final Report to National Climate Change Adaptation Research Facility Gold Coast. Available from URLhttp:\/\/www.nccarf.edu.au\/publications\/broadacre-farmers-adapting-changing-climate","DOI":"10.1002\/9781118845028.ch15"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/1924119"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-6261.1952.tb01525.x"},{"volume-title":"Portfolio Selection: Efficient Diversification of Investments","year":"1959","author":"Markowitz H.","key":"e_1_2_6_14_1"},{"key":"e_1_2_6_15_1","first-page":"567","volume-title":"Applied Mathematical Programming Using Algebraic Systems","author":"McCarl B.","year":"1997"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/2329621"},{"key":"e_1_2_6_17_1","first-page":"86","article-title":"Debugging mathematical programming models: principles and practical strategies","volume":"64","author":"Pannell D.J.","year":"1996","journal-title":"Review of Marketing and Agricultural Economics"},{"volume-title":"Planfarm\u2010Bankwest Benchmarks 2011\/12","year":"2013","author":"Planfarm\u2010Bankwest","key":"e_1_2_6_18_1"},{"volume-title":"Planfarm\u2010Bankwest Benchmarks 2012\/13","year":"2014","author":"Planfarm\u2010Bankwest","key":"e_1_2_6_19_1"},{"volume-title":"Planfarm\u2010Bankwest Benchmarks 2013\/14","year":"2015","author":"Planfarm\u2010Bankwest","key":"e_1_2_6_20_1"},{"key":"e_1_2_6_21_1","first-page":"1371","volume-title":"Climate Change 2014: Impacts, Adaptation, and Vulnerability","author":"Reisinger A.","year":"2014"},{"key":"e_1_2_6_22_1","unstructured":"Schoknecht N.andPathan S.(2013).Soil Groups of Western Australia Resource Management Technical Report 380 Department of Agriculture and Food Western Australia South Perth WA."},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-6261.1964.tb02865.x"},{"key":"e_1_2_6_24_1","unstructured":"Stephens D.(2016).South\u2010west Western Australia is losing is Mediterranean climate. Invited paper to the GRDC Grains Research Updates Perth Convention Centre March 1 2016. Available in session 12 from URL:http:\/\/www.giwa.org.au\/2016researchupdates"},{"key":"e_1_2_6_25_1","unstructured":"Thamo T.(2016).Climate change in Western Australian agriculture: a Bioeconomic and policy analysis. Unpublished PhD thesis School of Agricultural and Resource Economics University of Western Australia Crawley WA."}],"container-title":["Australian Journal of Agricultural and Resource Economics"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1467-8489.12229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1467-8489.12229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T20:49:04Z","timestamp":1696020544000},"score":7.584337,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1467-8489.12229"}},"issued":{"date-parts":[[2017,10,24]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/1467-8489.12229"],"URL":"https:\/\/doi.org\/10.1111\/1467-8489.12229","archive":["Portico"],"ISSN":["1364-985X","1467-8489"],"issn-type":[{"type":"print","value":"1364-985X"},{"type":"electronic","value":"1467-8489"}],"published":{"date-parts":[[2017,10,24]]},"assertion":[{"value":"2017-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:58:09Z","timestamp":1747148289754,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015539","name":"Australian Government","doi-asserted-by":"publisher","award":["Research Training Scholarship"],"award-info":[{"award-number":["Research Training Scholarship"]}],"id":[{"id":"10.13039\/100015539","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Sport Science"],"published-print":{"date-parts":[[2024,5]]},"abstract":"Abstract<\/jats:title>Cardiovascular (CV) disease accounts for one third of deaths in females, with hypertension (HTN) and type 2 diabetes mellitus (T2DM) risk factors for its development. Global longitudinal strain (GLS) is a strong prognostic indicator for future CV dysfunction and can be impaired in women with HTN and T2DM. This study aimed to determine if exercise impacts GLS in women with HTN or T2DM. A randomized crossover trial was conducted with 15 women (aged 64.1\u00a0\u00b1\u00a04.7) diagnosed with HTN (n<\/jats:italic>\u00a0=\u00a012) or T2DM (n<\/jats:italic>\u00a0=\u00a03). Participants completed an 8\u2010week exercise and 8\u2010week non\u2010exercising control period, separated by a 21.6\u00a0\u00b1\u00a014.2\u2010week washout period. Resting echocardiography and exercise testing were performed pre and post each arm to measure GLS and aerobic fitness (VO2<\/jats:sub>peak). GLS (%) improved significantly following exercise (\u221216.8\u00a0\u00b1\u00a01.5 to \u221218.4\u00a0\u00b1\u00a01.8; p<\/jats:italic>\u00a0\u2264<\/jats:italic>\u00a00.001, d<\/jats:italic>\u00a0=\u00a00.98), but not control (\u221217.2\u00a0\u00b1\u00a02.0 to \u221216.9\u00a0\u00b1\u00a01.4; p<\/jats:italic>\u00a0=\u00a00.585, d<\/jats:italic>\u00a0=\u00a0\u22120.14). Similarly, VO2<\/jats:sub>peak (mL\/kg\/min) increased following exercise (18.0\u00a0\u00b1\u00a02.1 to 19.2\u00a0\u00b1\u00a02.6; p<\/jats:italic>\u00a0\u2264<\/jats:italic>\u00a00.001, d<\/jats:italic>\u00a0=\u00a00.53), but not control (17.5\u00a0\u00b1\u00a02.7\u201317.2\u00a0\u00b1\u00a02.7; p<\/jats:italic>\u00a0=\u00a00.269, d<\/jats:italic>\u00a0=\u00a0\u22120.12). There were significant between\u2010group differences for GLS (p<\/jats:italic>\u00a0\u2264<\/jats:italic>\u00a00.001, d<\/jats:italic>\u00a0=\u00a01.02) and VO2<\/jats:sub>peak (p<\/jats:italic>\u00a0=\u00a00.011, d<\/jats:italic>\u00a0=\u00a00.63). Aerobic exercise positively impacts GLS and VO2<\/jats:sub>peak in women with HTN and T2DM. GLS may inform exercise professionals regarding the early effectiveness of an aerobic exercise intervention and infer a reduction in CV disease risk.<\/jats:p>","DOI":"10.1002\/ejsc.12047","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T08:30:00Z","timestamp":1710750600000},"page":"527-536","source":"Crossref","is-referenced-by-count":0,"title":["Exercise positively impacts global longitudinal strain in women at risk of developing cardiovascular disease"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-4951","authenticated-orcid":false,"given":"James","family":"Murray","sequence":"first","affiliation":[{"name":"Allied Health and Human Performance University of South Australia Adelaide South Australia Australia"},{"name":"Alliance for Research in Exercise, Nutrition and Activity University of South Australia Adelaide South Australia Australia"},{"name":"Cancer Research Institute University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8541-9104","authenticated-orcid":false,"given":"Hunter","family":"Bennett","sequence":"additional","affiliation":[{"name":"Allied Health and Human Performance University of South Australia Adelaide South Australia Australia"},{"name":"Alliance for Research in Exercise, Nutrition and Activity University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1315-1735","authenticated-orcid":false,"given":"Eva","family":"Bezak","sequence":"additional","affiliation":[{"name":"Allied Health and Human Performance University of South Australia Adelaide South Australia Australia"},{"name":"Cancer Research Institute University of South Australia Adelaide South Australia Australia"},{"name":"Department of Physics University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3333-3317","authenticated-orcid":false,"given":"Rebecca","family":"Perry","sequence":"additional","affiliation":[{"name":"Allied Health and Human Performance University of South Australia Adelaide South Australia Australia"},{"name":"Cancer Research Institute University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2023.04.008"},{"volume-title":"ACSM's Guidelines for Exercise Testing and Prescription","year":"2013","author":"American College of Sports Medicine","key":"e_1_2_9_3_1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.08.012"},{"volume-title":"Borg's Perceived Exertion and Pain Scales","year":"1998","author":"Borg 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Prima facie, employment figures across a whole sector or employment segment can appear to be broadly representative of the Australian population, but looking more closely, it becomes apparent that the \u2018devil is in the level\u2019. Although there is often parity at the macro level, drilling down into specific roles and their differential levels of seniority and power reveals inequalities between those in key and more secure gatekeeping positions and those further down the organisational hierarchy. Focusing on gender, this article will argue that the lack of diversity at senior levels of employment is a key contributing factor to lack of diversity within cultural and creative industries, reinforcing power imbalances and social and economic inequity.<\/jats:p>","DOI":"10.1177\/1329878x19892772","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T08:20:57Z","timestamp":1576657257000},"page":"3-18","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["\u2018The devil is in the level\u2019: understanding inequality in Australia\u2019s Film, TV and Radio industries"],"prefix":"10.1177","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6047-4767","authenticated-orcid":false,"given":"Susan","family":"Luckman","sequence":"first","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Anderson","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchi","family":"Sinha","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Rentschler","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Chalklen","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"key":"bibr1-1329878X19892772","unstructured":"ABS (2016) Customized Report."},{"key":"bibr2-1329878X19892772","unstructured":"ABS (2018) Customized Report."},{"key":"bibr3-1329878X19892772","volume-title":"Indigenous Socioeconomic Change 1971\u20132001: A Historical Perspective","author":"Altman J","year":"2004"},{"key":"bibr4-1329878X19892772","unstructured":"Australian Broadcasting Corporation (ABC) (2016) Equity and Diversity Plan 2016\u20132018. 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This multicenter retrospective cohort study investigated the natural history and assessed the predictors of outcomes in patients with AIH, PBC, and PSC.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n AIH, PBC, and PSC patients were identified from the state\u2010wide Hepascore and Clinical Outcome cohort. Overall death or transplant, liver\u2010related mortality (liver\u2010related death or transplant), and liver\u2010related decompensation were determined using a population\u2010based data linkage system. Baseline Liver Outcome Score (LOS), Hepascore, and MELD were examined for predicting outcomes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Two\u2010hundred thirty\u2010seven AIH patients (24% male, median age 56.6\u2009years [range, 14.3\u201394.0]), 157 PBC patients (8.3% male, median age 60.5\u2009years [range, 25.6\u201387.1]), and 167 PSC patients (52.7% male, median age 55.6\u2009years [range, 18.4\u201388.6]) were enrolled. Five\u2010year transplant\u2010free survival was 88% (95%CI: 81\u201392%) in AIH, 92% (95%CI: 85\u201396%) in PBC, and 61% (95%CI: 51\u201369%) in PSC. PSC had a significantly worse overall death or transplant, liver\u2010related mortality, and liver\u2010related decompensation when compared to AIH and PBC (\n p<\/jats:italic>\n \u2009<\u20090.0001). LOS was a significant independent predictor of overall death or transplant, liver\u2010related mortality, and liver\u2010related decompensation among patients with AIH and PBC. LOS was a significant independent predictor of overall death or transplant in patients with PSC, and Hepascore was a significant independent predictor of liver\u2010related mortality and liver\u2010related decompensation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Outcomes for AIH and PBC are excellent but remain poor in PSC. LOS is a predictor of outcomes in autoimmune liver disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.16850","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T03:45:46Z","timestamp":1734407146000},"page":"731-740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Natural History and Predictors of Clinical Outcomes in Autoimmune Liver Diseases: A Multicenter Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9722-661X","authenticated-orcid":false,"given":"Dujinthan","family":"Jayabalan","sequence":"first","affiliation":[{"name":"Department of Hepatology Sir Charles Gairdner Hospital Nedlands Western Australia Australia"},{"name":"Medical School The University of Western Australia Nedlands Western Australia 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Hepatology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.16850","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.16850","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.16850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T01:03:59Z","timestamp":1771203839000},"score":7.584025,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.16850"}},"issued":{"date-parts":[[2024,12,17]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/jgh.16850"],"URL":"https:\/\/doi.org\/10.1111\/jgh.16850","archive":["Portico"],"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"published":{"date-parts":[[2024,12,17]]},"assertion":[{"value":"2024-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:17:25Z","timestamp":1788412645440,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian J Rural Health"],"published-print":{"date-parts":[[2023,6]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To examine the principal place of practice after graduation of students who participated in the Rural Health Multidisciplinary Training (RHMT) program and allied health students' place of origin.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Cross\u2010sectional study.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Graduates who completed their degree in podiatry, occupational therapy and physiotherapy in 2019.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n Principal place of practice at first and third years after graduation.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In 2020, 40 allied health professionals (AHPs) who graduated from the University of South Australia in 2019 were practising in rural areas but only 26 of them remained in the rural practice in 2022. The retention rate for rural practice was 65% within 2\u2009years. However, in 2022, 25 allied health professionals left their metropolitan employment location and transitioned to rural practice. Of the 25 allied health graduates who joined the rural practice in 2022, most of them (80%, 20\/25) had either rural exposure through the RMHT program or were from rural origin.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Rural exposure via the RHMT program and allied health students' rural place of origin have an important role for rural principal place of practice at first and third years after graduation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ajr.12974","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T05:54:33Z","timestamp":1677563673000},"page":"575-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Do undertaking rural placements and place of origin inform where allied health graduates work in South Australia?"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3033-5325","authenticated-orcid":false,"given":"Lee San","family":"Puah","sequence":"first","affiliation":[{"name":"Department of Rural Health University of South Australia Whyalla Norrie and Mount Barker South Australia Australia"},{"name":"IIMPACT in Health University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0169-3964","authenticated-orcid":false,"given":"Marianne","family":"Gillam","sequence":"additional","affiliation":[{"name":"Department of Rural Health University of South Australia Whyalla Norrie and Mount Barker South Australia Australia"},{"name":"IIMPACT in Health University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9702-652X","authenticated-orcid":false,"given":"Sandra","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Rural Health University of South Australia Whyalla Norrie and Mount Barker South Australia Australia"},{"name":"IIMPACT in Health University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6463-3574","authenticated-orcid":false,"given":"Martin","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Rural Health University of South Australia Whyalla Norrie and Mount Barker South Australia Australia"},{"name":"IIMPACT in Health University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0703-1515","authenticated-orcid":false,"given":"Engida","family":"Yisma","sequence":"additional","affiliation":[{"name":"Department of Rural Health University of South Australia Whyalla Norrie and Mount Barker South Australia Australia"},{"name":"IIMPACT in Health University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.13.119008"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajr.12805"},{"key":"e_1_2_11_4_1","unstructured":"Australian Institute of Health and Welfare.Health workforce.2020. Available from:https:\/\/www.aihw.gov.au\/reports\/australias\u2010health\/health\u2010workforce"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajr.12816"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19031438"},{"key":"e_1_2_11_7_1","unstructured":"Services for Australian Rural & Remote Allied Health.About us.2022. Available from:https:\/\/sarrah.org.au\/about\u2010us"},{"key":"e_1_2_11_8_1","unstructured":"Department of Health.Rural Health Multidisciplinary Training (RHMT) Program Framework 2019\u20132020.2019. Available from:https:\/\/www.health.gov.au\/sites\/default\/files\/documents\/2021\/10\/evaluation\u2010of\u2010the\u2010rural\u2010health\u2010multidisciplinary\u2010training\u2010rhmt\u2010program\u2010final\u2010report_0.pdf"},{"key":"e_1_2_11_9_1","first-page":"S18","article-title":"The role of national policies to address rural allied health, nursing and dentistry workforce maldistribution","volume":"213","author":"Walsh S","year":"2020","journal-title":"Med J Aust"},{"key":"e_1_2_11_10_1","unstructured":"Department of Health.Modified monash model.2021. Available from:https:\/\/www.health.gov.au\/health\u2010topics\/rural\u2010health\u2010workforce\/classifications\/mmm"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1584.2006.00745.x"},{"issue":"1","key":"e_1_2_11_12_1","first-page":"5334","article-title":"Factors associated with rural work for nursing and allied health graduates 15\u201017\u2009years after an undergraduate rural placement through the University Department of Rural Health program","volume":"20","author":"Playford D","year":"2020","journal-title":"Rural Remote Health"},{"issue":"2","key":"e_1_2_11_13_1","first-page":"79","article-title":"Longitudinal tracking of workplace outcomes for undergraduate allied health students undertaking placements in rural Australia","volume":"46","author":"Brown L","year":"2017","journal-title":"J Allied Health"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajr.12662"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmrs.559"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajr.12722"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajr.12864"}],"container-title":["Australian Journal of Rural Health"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajr.12974","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajr.12974","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajr.12974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T13:30:46Z","timestamp":1692538246000},"score":7.5839787,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajr.12974"}},"issued":{"date-parts":[[2023,2,28]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/ajr.12974"],"URL":"https:\/\/doi.org\/10.1111\/ajr.12974","archive":["Portico"],"ISSN":["1038-5282","1440-1584"],"issn-type":[{"value":"1038-5282","type":"print"},{"value":"1440-1584","type":"electronic"}],"published":{"date-parts":[[2023,2,28]]},"assertion":[{"value":"2022-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:05:53Z","timestamp":1767841553833,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"S6","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The relationship between diet, gut microbiota, and neurocognition is pivotal in addressing age\u2010related cognitive decline and neurodegenerative diseases. Modifiable factors, particularly dietary patterns, significantly influence cognitive health and gut microbiota. Healthy diets like the Mediterranean (MeDi), DASH, and MIND promote microbial diversity, reduce neuroinflammation, and support cognitive function. In contrast, the Western Diet (WD), high in refined sugars and saturated fats, disrupts gut microbiota, lowers SCFA production, and exacerbates neuroinflammatory pathways, contributing to cognitive impairment.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n A narrative review was conducted with the aim of summarising available scientific evidence to identify key dietary components responsible for the cognitive performances of adults and their effects on gut microbiota composition.<\/jats:p>\n <\/jats:sec>\n \n Result<\/jats:title>\n Macronutrients such as carbohydrates, proteins, fats, and micronutrients, including vitamins B, D, and E, and minerals like magnesium and zinc exhibit neuroprotective effects. Some nutrient components, such as omega\u20103 fatty acids, reduce inflammation and oxidative stress in the brain and gut, while high dietary fiber enhances SCFA production and maintains gut barrier integrity. Notably, prebiotic and probiotic supplements have shown the potential to improve cognitive function by modulating gut microbiota composition. In clinical trials, probiotic strains such as Lactobacillus rhamnosus and Bifidobacterium longum have significantly improved cognitive levels and the level of anxiety.<\/jats:p>\n \n Emerging evidence underscores the rapid and bidirectional response of gut microbiota to alteration of the dietary pattern. High\u2010fiber diets enhance beneficial bacteria, such as\n Bifidobacterium<\/jats:italic>\n and\n Akkermansia muciniphila<\/jats:italic>\n , while fiber\u2010deprived diets correlate with increased diversity of unhealthy bacteria, resulting in cognitive decline and hippocampal synaptic loss.\n <\/jats:p>\n There is substantial evidence supporting the role of diet in mitigating cognitive decline and maintaining a healthy gut microbiota composition. This review highlights dietary components, such as plant\u2010based foods, probiotics, and prebiotics, which positively influence both cognitive health and gut microbiota balance. However, inconsistencies in findings from long\u2010term dietary intervention studies underscore the need for robust, large\u2010scale trials to establish causality.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In conclusion, the review emphasizes the importance of personalized dietary strategies tailored to an individual's gut microbiota composition as a promising approach for preserving cognitive health and preventing neurodegenerative diseases, warranting further research in this area.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz70860_105330","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T19:40:48Z","timestamp":1766518848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Diet and Gut Microbiota on Cognitive Health: A Comprehensive Review"],"prefix":"10.1002","volume":"21","author":[{"given":"Samantha","family":"Ramachandra","sequence":"first","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid R","family":"Sohrabi","sequence":"additional","affiliation":[{"name":"Murdoch university, Murdoch, Western Australia, Australia"},{"name":"Australian Alzheimer's Research Foundation, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Ho","sequence":"additional","affiliation":[{"name":"Western Sydney University, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BGDNK De","family":"Silva","sequence":"additional","affiliation":[{"name":"University of Sri Jayewardenepura, Colombo, Western Province, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warnakulasuriya Mary Ann Dipika Binosha","family":"Fernando","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia, Australia"},{"name":"Alzheimer's Research Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph N","family":"Martins","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia, Australia"},{"name":"Alzheimer's Research Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,23]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz70860_105330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T21:52:05Z","timestamp":1767822725000},"score":7.583968,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz70860_105330"}},"issued":{"date-parts":[[2025,12]]},"references-count":0,"journal-issue":{"issue":"S6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/alz70860_105330"],"URL":"https:\/\/doi.org\/10.1002\/alz70860_105330","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e105330"},{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T01:10:09Z","timestamp":1747357809465,"version":"3.40.5"},"reference-count":0,"publisher":"Clinical Exercise Physiology Association","issue":"s2","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2024,5]]},"abstract":"\n INTRODUCTION<\/jats:title>\n Adolescents and young adults (AYAs) experience vast symptom burden resulting from cancer treatment-related toxicities (TRTs). Evidence supports exercise to mitigate several TRTs in other cohorts, however evidence in AYAs is lacking. Conventional reporting of TRTs adopts a maximum grade approach failing to recognise the trajectory over time or lower grade toxicities. Alternatively, longitudinal analysis of toxicities over time (ToxT) may provide clinically meaningful summaries of this data. We evaluated the longitudinal impact of an exercise intervention on TRTs in AYAs undergoing cancer treatment.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n A prospective, randomised trial allocated participants to a 10-week exercise intervention (EG) or control group (CG) undergoing usual care. Detailed information on TRTs was collected throughout the intervention. All TRTs were graded per the Common Terminology Criteria for Adverse Events (CTCAE v5.0).<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Forty-three (43) participants (63% male, mean age 21.1 years) were enrolled. When categorised to reflect the maximal worst grade experienced (Grade 0, Grade 1-2 and \u2265Grade 3), the CG reported an increased incidence of severe fatigue (\u2265Grade 3) compared with the EG (p=0.05). No other differences between groups were evident (p>0.05). ToxT analysis of the four most common toxicities (fatigue, pain, nausea and mood disturbances) demonstrated no difference in the mean grade of each over time (p>0.05). Additionally, area under the curve (AUC) analysis revealed trends towards a higher magnitude of fatigue (mean AUC 12.5 vs 11.1 p=0.11) and mood disturbances (mean AUC 7.2 vs 5.7 p=0.28) over time in the CG. No differences were evident for pain and nausea between groups (p>0.05).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n A 10-week exercise intervention reduces the severity of fatigue in AYAs undergoing treatment. While the ToxT approach provided insight into the toxicity profile, adequately powered studies are needed to better understand these differences within a homogeneous sample<\/jats:p>\n <\/jats:sec>","DOI":"10.31189\/2165-7629-13-s2.322","type":"journal-article","created":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T14:35:53Z","timestamp":1714919753000},"page":"322","source":"Crossref","is-referenced-by-count":0,"title":["POTENTIAL IMPACT OF EXERCISE UPON SYMPTOM BURDEN IN ADOLESCENTS AND YOUNG ADULTS UNDERGOING CANCER TREATMENT"],"prefix":"10.31189","volume":"13","author":[{"given":"Dr Claire","family":"Munsie","sequence":"first","affiliation":[{"name":"WA Youth Cancer Service, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia"},{"name":"School of Human Sciences, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dr Jay","family":"Ebert","sequence":"additional","affiliation":[{"name":"School of Human Sciences, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Professor David","family":"Joske","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Western Australia, Perth, Western Australia, Australia"},{"name":"Sir Charles Gairdner Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Collins","sequence":"additional","affiliation":[{"name":"WA Youth Cancer Service, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia"},{"name":"Sir Charles Gairdner Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prof Tim","family":"Ackland","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16145","container-title":["Journal of Clinical Exercise Physiology"],"link":[{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/13\/s2\/article-p322-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/jcep\/article-pdf\/13\/s2\/322\/3369462\/i2165-7629-13-s2-322.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/13\/s2\/article-p322-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/13\/s2\/article-p322-s.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:39:26Z","timestamp":1747355966000},"score":7.583851,"resource":{"primary":{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/13\/s2\/article-p322-s.xml"}},"issued":{"date-parts":[[2024,5]]},"references-count":0,"journal-issue":{"issue":"s2"},"URL":"https:\/\/doi.org\/10.31189\/2165-7629-13-s2.322","ISSN":["2165-7629","2165-6193"],"issn-type":[{"type":"electronic","value":"2165-7629"},{"type":"print","value":"2165-6193"}],"published":{"date-parts":[[2024,5]]}},{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:47:42Z","timestamp":1777452462238,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100010433","name":"Cooperative Research Centre for Living with Autism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010433","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Autism"],"published-print":{"date-parts":[[2026,3]]},"abstract":"\n This study aimed to identify guiding principles to underpin assessment and diagnosis of autism to improve the quality, consistency and accuracy of services provided to individuals and their families. An online survey and focus groups were used to capture community perspectives of members of the Australian autistic and autism communities. A total of 871 individuals participated across the research activities, including autistic individuals (\n n<\/jats:italic>\n \u2009=\u2009253), parents of autistic individuals (\n n<\/jats:italic>\n \u2009=\u2009344), practitioners (\n n<\/jats:italic>\n \u2009=\u2009325) and members of organisations with an interest in the assessment and\/or diagnosis of autism (\n n<\/jats:italic>\n \u2009=\u2009115). Three overarching themes, encompassing 15 codes, representing the principles that should underpin practice across the assessment and diagnostic process were developed (a) placing the person at the centre of the process; (b) understanding and valuing the whole person and (c) improving quality and access. Assessment and diagnosis for autism should go beyond diagnostic decision-making to include understanding of individual needs and identifying support pathways. The principles identified serve as a first step to guiding practitioners in their approach, ensuring they work in ways that promote best practice, reflect the perspectives of autistic people and engender meaningful outcomes for individuals and families that are independent of receiving a diagnostic label.\n <\/jats:p>\n \n Lay Abstract<\/jats:title>\n This study looked to identify principles of practice that could help make autism assessments and diagnoses better for autistic people and their families. To do this, the researchers asked people from the autism community in Australia to share their thoughts through an online survey and focus groups. A total of 871 people took part. This included autistic adults, parents of autistic children, professionals like psychologists and speech pathologists and people from autism-related organisations. From what people said, three main ideas stood out: (a) putting people at the centre of the process, (b) looking at the whole person and (c) improving quality and access to services. The study found that getting a diagnosis is just one part of the process. It is also important to use the assessment to help people understand themselves better and find the right support. The principles highlighted in this study can help guide professionals to do a better job when assessing autism. They encourage practices that are respectful, person-focused and based on what autistic people and their families say is important. This can lead to better outcomes for everyone, no matter whether a diagnosis is given or not.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/13623613251406094","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T23:54:36Z","timestamp":1769471676000},"page":"642-654","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Community views on the assessment and diagnosis of autism: Principles to guide clinical practice"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-1316","authenticated-orcid":false,"given":"Rhylee","family":"Sulek","sequence":"first","affiliation":[{"name":"Griffith University, Australia"},{"name":"CliniKids\u2013The Kids Research Institute Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4564-6924","authenticated-orcid":false,"given":"Rachelle","family":"Wicks","sequence":"additional","affiliation":[{"name":"Griffith University, Australia"},{"name":"CliniKids\u2013The Kids Research Institute Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5821-8029","authenticated-orcid":false,"given":"Emma","family":"Hinze","sequence":"additional","affiliation":[{"name":"Griffith University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Dargue","sequence":"additional","affiliation":[{"name":"Griffith University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Briohny","family":"Dempsey","sequence":"additional","affiliation":[{"name":"CliniKids\u2013The Kids Research Institute Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Goodall","sequence":"additional","affiliation":[{"name":"Griffith University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libby","family":"Groves","sequence":"additional","affiliation":[{"name":"Griffith University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4699-6195","authenticated-orcid":false,"given":"David","family":"Trembath","sequence":"additional","affiliation":[{"name":"Griffith University, Australia"},{"name":"CliniKids\u2013The Kids Research Institute Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3787-0301","authenticated-orcid":false,"given":"Hannah","family":"Waddington","sequence":"additional","affiliation":[{"name":"Te Herenga Waka\u2013Victoria University of Wellington, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8722-1575","authenticated-orcid":false,"given":"Andrew JO","family":"Whitehouse","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, The University of Western Australia, Australia"},{"name":"Autism CRC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3412-7910","authenticated-orcid":false,"given":"Kandice J","family":"Varcin","sequence":"additional","affiliation":[{"name":"Griffith University, Australia"},{"name":"CliniKids\u2013The Kids Research Institute Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_3_3_2_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1980","unstructured":"American Psychiatric Association. 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However, outboard in water depths greater than 500\u2009m, the basin is underexplored with distant well control and sparse 2D reflection seismic data coverage. The presence of a successful petroleum province onshore and in shallow waters raises the question as to whether these plays may extend further outboard into the deep-water areas. In the deep-water area, structural complexity and poor imaging of events in the legacy seismic data have resulted in interpretation uncertainty and consequentially a high-risk profile for explorers. The 2020 Otway Basin seismic program acquired over 7000-line km of 2D reflection seismic data across the deep-water Otway Basin. In addition, over 10\u2009000\u2009km of legacy 2D seismic data were reprocessed to improve the tie between the inboard wells and the new seismic grid. This new dataset provides the first clear insight into the structural and stratigraphic framework of this frontier area, including better imaging of the sedimentary section and the lower crust, increased structural resolution and improved calibration of the outboard seismic reflectors via ties to the inboard wells. Interpretation of the new data has led to an improved assessment of the structural elements and the extension of regional supersequences into the deep-water areas. These refinements have been used as input into petroleum systems modelling work and will provide a foundation for future work to understand petroleum prospectivity, including the distribution of source, reservoir and seal facies.<\/jats:p>","DOI":"10.1071\/aj20092","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T02:22:09Z","timestamp":1625192529000},"page":"657-664","source":"Crossref","is-referenced-by-count":4,"title":["New insights into the deep-water Otway Basin \u2013 Part 2. Tectonostratigraphic framework revealed by new seismic data"],"prefix":"10.1071","volume":"61","author":[{"given":"Alex","family":"Karvelas","sequence":"first","affiliation":[{"name":"ASchlumberger, Perth, Australia."},{"name":"ECorresponding author. 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Atypical nested deletions and duplications are rarer and can provide a valuable opportunity to investigate the dosage effects of a smaller subset of genes within the 22q11.2 genomic disorder region.<\/jats:p><\/jats:sec>Methods<\/jats:title>We describe thirteen individuals from six families, each with atypical nested duplications within the central 22q11.2 region between LCR<\/jats:styled-content>22B and LCR<\/jats:styled-content>22D. We then compared the molecular and clinical data for patients from this study and the few reported atypical duplication cases, to the cases with larger typical duplications between LCR<\/jats:styled-content>22A and LCR<\/jats:styled-content>22D. Further, we analyzed genes with the nested region to identify candidates highly enriched in human brain tissues.<\/jats:p><\/jats:sec>Results<\/jats:title>We observed that atypical nested duplications are heterogeneous in size, often familial, and associated with incomplete penetrance and highly variable clinical expressivity. We found that the nested atypical duplications are a possible risk factor for neurodevelopmental phenotypes, particularly for autism spectrum disorder (ASD<\/jats:styled-content>), speech and language delay, and behavioral abnormalities. In addition, we analyzed genes within the nested region between LCR<\/jats:styled-content>22B and LCR<\/jats:styled-content>22D to identify nine genes (ZNF<\/jats:styled-content>74, KLHL<\/jats:styled-content>22, MED<\/jats:styled-content>15, PI<\/jats:styled-content>4KA<\/jats:styled-content>, SERPIND<\/jats:styled-content>1, CRKL<\/jats:styled-content>, AIFM<\/jats:styled-content>3, SLC<\/jats:styled-content>7A4, and BCRP<\/jats:styled-content>2)<\/jats:italic> with enriched expression in the nervous system, each with unique spatiotemporal patterns in fetal and adult brain tissues. Interestingly, PI<\/jats:styled-content>4KA<\/jats:styled-content><\/jats:italic> is prominently expressed in the brain, and this gene is included either partially or completely in all of our subjects.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our findings confirm variable expressivity and incomplete penetrance for atypical nested 22q11.2 duplications and identify genes such as PI<\/jats:styled-content>4KA<\/jats:styled-content><\/jats:italic> to be directly relevant to brain development and disorder. We conclude that further work is needed to elucidate the basis of variable neurodevelopmental phenotypes and to exclude the presence of a second disorder. Our findings contribute to the genotype\u2013phenotype data for atypical nested 22q11.2 duplications, with implications for genetic counseling.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mgg3.507","type":"journal-article","created":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T02:30:09Z","timestamp":1546828209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Atypical nested 22q11.2 duplications between LCR<\/scp>22B and LCR<\/scp>22D are associated with neurodevelopmental phenotypes including autism spectrum disorder with incomplete penetrance"],"prefix":"10.1002","volume":"7","author":[{"given":"Karen J.","family":"Woodward","sequence":"first","affiliation":[{"name":"Diagnostic Genomics PathWest Laboratory Medicine Perth Western Australia Australia"},{"name":"School of Biomedical Sciences University of Western Australia Perth Western Australia 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While ultrasound-guided and microinvasive approaches have demonstrated safety and technical precision, prospective data describing Return-to-Work (RTW) and early functional recovery remain limited. Materials and Methods: This prospective cohort study included adults undergoing office-based ultrasound-guided microinvasive CTR (Micro-CTR) under local anaesthesia using a retractable needle-mounted blade system. Patient-reported outcomes were collected using the Comprehensive Carpal Tunnel Recovery Questionnaire. The primary outcome was time to RTW. Secondary outcomes included change in pain score, analgesic duration, and time to return to driving and household tasks. Continuous outcomes were non-normally distributed and are reported as medians with interquartile ranges (IQRs). Recovery outcomes were compared by structured self-reported postoperative-event status using non-parametric and time-to-event analyses, and an exploratory distributional analysis assessed the influence of longer self-reported RTW intervals on the overall recovery distribution. Results: Sixty-seven patients were included. Median RTW was 9 days (IQR, 30.5; n = 48), with a median return to driving at 5 days (IQR 6) and household tasks at 7 days (IQR 7). Median pain decreased from 8\/10 preoperatively to 0\/10 postoperatively (p < 0.0001). Participants reporting at least one structured postoperative event had longer RTW intervals than those selecting no structured event (median 35 vs. 5 days; HR 0.42, 95% CI 0.22\u20130.80; p = 0.0079). Exploratory distributional analysis showed that longer RTW intervals had a substantial influence on the overall RTW distribution; the full RTW responder cohort remained the primary analysis. Conclusions: Ultrasound-guided Micro-CTR was associated with rapid early functional recovery in most patients in this prospective cohort. Recovery was heterogeneous, with longer RTW intervals observed among participants reporting structured postoperative events. These findings support RTW as a pragmatic functional endpoint in evaluating emerging CTR techniques.<\/jats:p>","DOI":"10.3390\/medicina62081441","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:38:41Z","timestamp":1784889521000},"page":"1441","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Return-to-Work and Early Functional Recovery Following Office-Based Ultrasound-Guided Microinvasive Carpal Tunnel Release: A Prospective Cohort Study"],"prefix":"10.3390","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5178-7630","authenticated-orcid":false,"given":"Christian A.","family":"Lobos","sequence":"first","affiliation":[{"name":"Carpal Tunnel Institute, Melbourne, VIC 3056, Australia"},{"name":"Carpal Tunnel Australia, Adelaide, SA 5000, Australia"},{"name":"Carpal Tunnel Australia, Brisbane, QLD 4000, Australia"},{"name":"Carpal Tunnel Australia, Canberra, ACT 2600, Australia"},{"name":"Carpal Tunnel Australia, Sydney, NSW 2000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Wilcox","sequence":"additional","affiliation":[{"name":"Carpal Tunnel Institute, Melbourne, VIC 3056, Australia"},{"name":"Carpal Tunnel Australia, Adelaide, SA 5000, Australia"},{"name":"Carpal Tunnel Australia, Brisbane, QLD 4000, Australia"},{"name":"Carpal Tunnel Australia, Canberra, ACT 2600, Australia"},{"name":"Carpal Tunnel Australia, Sydney, NSW 2000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidan","family":"Cottrell","sequence":"additional","affiliation":[{"name":"Carpal Tunnel Institute, Melbourne, VIC 3056, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomaz","family":"De Campos Silva","sequence":"additional","affiliation":[{"name":"Carpal Tunnel Institute, Melbourne, VIC 3056, Australia"},{"name":"Carpal Tunnel Australia, Adelaide, SA 5000, Australia"},{"name":"Carpal Tunnel Australia, Brisbane, QLD 4000, Australia"},{"name":"Carpal Tunnel Australia, Canberra, ACT 2600, Australia"},{"name":"Carpal Tunnel Australia, Sydney, NSW 2000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7549-4584","authenticated-orcid":false,"given":"Shea","family":"Wilcox","sequence":"additional","affiliation":[{"name":"Carpal Tunnel Institute, Melbourne, VIC 3056, Australia"},{"name":"Carpal Tunnel Australia, Adelaide, SA 5000, Australia"},{"name":"Carpal Tunnel Australia, Brisbane, QLD 4000, Australia"},{"name":"Carpal Tunnel Australia, Canberra, ACT 2600, Australia"},{"name":"Carpal Tunnel Australia, Sydney, NSW 2000, Australia"},{"name":"Faculty of Health, Torrens University, Melbourne, VIC 3000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1001\/jama.282.2.153","article-title":"Prevalence of Carpal Tunnel Syndrome in a General Population","volume":"282","author":"Atroshi","year":"1999","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3122\/jabfm.16.6.533","article-title":"Carpal Tunnel Syndrome as an Occupational Disease","volume":"16","author":"Kao","year":"2003","journal-title":"J. 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These time\u2010use behaviours are not independent, rather, co\u2010dependent parts of the 24\u2010hour day. As such, spending more time in one leaves less time for the others. The balance of the three time\u2010use behaviours in the 24\u2010hour day (or time\u2010use composition) should be considered to inform 24\u2010hour movement guidelines for cognition and dementia risk reduction in older populations. Using a compositional data analysis approach, we investigated the associations between time use and cognition in a sample of healthy older adults.<\/jats:p><\/jats:sec>Method<\/jats:title>347 participants (age 60\u201070 years; 68% female) took part in this study. 7 days of 24\u2010hour time use (time spent in sleep, sedentary behaviour, light and moderate\u2010vigorous physical activity) were captured using accelerometry. Cognition was measured using Addenbrooke\u2019s Cognitive Examination III (global cognition) and computerized CANTAB tests measuring memory, executive function, fluid reasoning and processing speed.<\/jats:p>Cognitive outcomes were regressed on isometric log ratios (ilrs) of the time\u2010use compositions, while adjusting for age and sex demographics, to explore potential associations between cognition and time\u2010use behaviours. For each outcome, four sets of ilr\u2010coordinate systems were constructed, each with a different time\u2010use behaviour as the numerator of a log ratio to the mean of remaining time\u2010use behaviours. The regression coefficient of the first ilr\u2010coordinate in each of the four ilr systems therefore represented the association between increasing time in the first behaviour relative to all remaining behaviours.<\/jats:p><\/jats:sec>Result<\/jats:title>Age was negatively associated with performance on memory, executive function, fluid reasoning and processing speed tests. More time in SB at the equal expense of all other behaviours was associated with better memory (\u03b2 = 0.65, p<.01), whilst spending more time in sleep was associated with poorer memory (\u03b2 = \u20100.63, p = .02). Spending more time in moderate\u2010vigorous physical activity was associated with better processing speed (\u03b2 = 0.25, p = .01).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>How older adults use their time is associated with cognition. Findings suggest that moving towards a holistic understanding of time use is important to inform future dementia prevention strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.060963","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T06:25:12Z","timestamp":1686896712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross\u2010sectional associations between use of time and cognition in healthy older adults"],"prefix":"10.1002","volume":"19","author":[{"given":"Maddison L","family":"Mellow","sequence":"first","affiliation":[{"name":"University of South Australia, Adelaide, SA Australia"},{"name":"Dementia Australia, Adelaide, SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashleigh E","family":"Smith","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothea","family":"Dumuid","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ty","family":"Stanford","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Keage","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Wade","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Olds","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montana","family":"Hunter","sequence":"additional","affiliation":[{"name":"University of Newcastle, Newcastle, NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frini","family":"Karayanidis","sequence":"additional","affiliation":[{"name":"University of Newcastle, Newcastle, NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian","family":"Dorrian","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell R","family":"Goldsworthy","sequence":"additional","affiliation":[{"name":"University of Adelaide, Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,16]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.060963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:56:40Z","timestamp":1759957000000},"score":7.583212,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.060963"}},"issued":{"date-parts":[[2023,6]]},"references-count":0,"journal-issue":{"issue":"S8","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/alz.060963"],"URL":"https:\/\/doi.org\/10.1002\/alz.060963","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"type":"print","value":"1552-5260"},{"type":"electronic","value":"1552-5279"}],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2023-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication 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Population-Based Clinic"],"prefix":"10.2337","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2823-0006","authenticated-orcid":false,"given":"Elaine E.","family":"Sanderson","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology, Perth Children\u2019s Hospital, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary B.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Perth Children\u2019s Hospital, Nedlands, Western Australia, Australia"},{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"},{"name":"The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Nedlands, Western Australia, Australia"},{"name":"The University of Western 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Institute, Nedlands, Western Australia, Australia"},{"name":"The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"2022031309554439500_B1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1001\/jama.2016.19975","article-title":"Effect of continuous glucose monitoring on glycemic control in adults with type 1 diabetes using insulin injections: the DIAMOND randomized clinical trial","volume":"317","author":"Beck","year":"2017","journal-title":"JAMA"},{"key":"2022031309554439500_B2","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1001\/jama.2020.6940","article-title":"Effect of continuous glucose monitoring on glycemic control in adolescents and young adults with type 1 diabetes: a randomized clinical 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2016-2018","volume":"21","author":"Foster","year":"2019","journal-title":"Diabetes Technol Ther"}],"container-title":["Diabetes Care"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/44\/9\/e171\/633218\/dc210304.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/44\/9\/e171\/633218\/dc210304.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T11:01:55Z","timestamp":1647169315000},"score":7.583158,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/44\/9\/e171\/138847\/Continuous-Glucose-Monitoring-Improves-Glycemic"}},"issued":{"date-parts":[[2021,7,19]]},"references-count":5,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,7,19]]},"published-print":{"date-parts":[[2021,9,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc21-0304","ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"published":{"date-parts":[[2021,7,19]]}},{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T21:30:58Z","timestamp":1778535058051,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T00:00:00Z","timestamp":1356480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To investigate general practitioners' (GPs<\/jats:styled-content>) preferences for involvement in the management of people diagnosed with the seven most frequent cancers and any barriers to or concerns about an expanded role for GPs<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A self\u2010report survey was mailed to a random sample of 1969 Australian GPs<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>In all, 33% (648) of GPs<\/jats:styled-content> participated. Participants were a median of 50 years and worked 38\u2009h per week; 53% were male and 68% practiced in metropolitan areas. Most participants preferred to be involved in cancer prevention (86%) and initial diagnosis (85%). Fewer were interested in monitoring for recurrence (70%), follow up after treatment (68%), coordinating psychological support (70%) and palliative care (68%). Only 52% of GPs<\/jats:styled-content> had a preference for providing supportive care to manage the symptoms of cancer treatment, 45% for managing postoperative care and 40% for coordinating treatment. On multivariate analysis, preference for involvement in more aspects of cancer management increased with age (P<\/jats:italic>\u2009=\u20090.030), if the GP<\/jats:styled-content> practiced in rural compared to metropolitan areas (P<\/jats:italic>\u2009=\u20090.005), was a partner in a practice compared to a sole practitioner (P<\/jats:italic>\u2009=\u20090.003), had previously received cancer\u2010specific training (P<\/jats:italic>\u2009<\u20090.001) or was interested in future training (P<\/jats:italic>\u2009<\u20090.001). Open responses identified limited time, communication and information transfer between GP<\/jats:styled-content> and specialists as important barriers to involvement in cancer management.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>While many GPs<\/jats:styled-content> are currently involved in some aspects of cancer management, with training, good communication and support from specialists this role may be successfully expanded.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.12047","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T01:39:59Z","timestamp":1356572399000},"source":"Crossref","is-referenced-by-count":31,"title":["Australian general practitioners' preferences for managing the care of people diagnosed with cancer"],"prefix":"10.1111","volume":"10","author":[{"given":"Claire E","family":"Johnson","sequence":"first","affiliation":[{"name":"School of Surgery University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Lizama","sequence":"additional","affiliation":[{"name":"School of Surgery University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Garg","sequence":"additional","affiliation":[{"name":"School of Surgery University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manonita","family":"Ghosh","sequence":"additional","affiliation":[{"name":"School of Surgery University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Emery","sequence":"additional","affiliation":[{"name":"School of Surgery University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christobel","family":"Saunders","sequence":"additional","affiliation":[{"name":"School of Surgery University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,26]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Older Australia at a Glance","author":"Australian Institute of Health and Welfare","year":"2002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2007.tb01156.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.2235"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7058.665"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603052"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e32801023a2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1584.2008.01019.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00278-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp09X453567"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/109662103322654794"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmn011"},{"key":"e_1_2_6_13_1","unstructured":"National Health and Hospitals Reform Commission.A Healthier Future for All Australians \u2013 Final Report of the National Health and Hospitals Reform Commission. Canberra 2009:107."},{"key":"e_1_2_6_14_1","first-page":"12","article-title":"General practice workforce gaps now and in 2020","volume":"40","author":"Harrison C","year":"2011","journal-title":"Aust Fam Physician"},{"key":"e_1_2_6_15_1","unstructured":"Australia Post.Print post sort plan guide2005[cited 8 November]. Available from:http:\/\/www1.auspost.com.au\/download\/PrintPost_sort_plan.pdf."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7227.114"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2007.04569.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049732305276687"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nedt.2003.10.001"},{"key":"e_1_2_6_20_1","unstructured":"AMPCo Data Direct.All practising doctors nationwide discipline statistics: state X country\/metro [online]. Email to Claire E. Johnson (claire.johnson@uwa.edu.au)2012Jan 25."},{"key":"e_1_2_6_21_1","unstructured":"Australian Institute of Health and Welfare.Medical labour force 2009. AIHW Bulletin no. 89. Cat. no. AUS 138. AIHW Canberra 2011."},{"key":"e_1_2_6_22_1","series-title":"General Practice Series No. 24","first-page":"219","volume-title":"General Practice in Australia, Health Priorities and Policies 1998 to 2008","author":"Britt H","year":"2009"},{"key":"e_1_2_6_23_1","series-title":"General Practice Series No. 29","volume-title":"General Practice Activity in Australia 2010\u201311","author":"Britt H","year":"2011"},{"key":"e_1_2_6_24_1","unstructured":"National Cancer Control Initiative.The primary care perspective on cancer \u2013 an introductory discussion. Melbourne 2003:1\u201343."},{"key":"e_1_2_6_25_1","unstructured":"Cancer Australia.Cancer learning2011. Australian Government. [cited 8 November]. Available from:http:\/\/www.cancerlearning.gov.au\/."},{"key":"e_1_2_6_26_1","volume-title":"eHealth Strategic Framework","author":"British Columbia eHealth Steering Committee","year":"2005"},{"key":"e_1_2_6_27_1","volume-title":"Primary Health Care Reform in Australia. Report to Support Australia's First National Primary Health Care Strategy","author":"Commonwealth of Australia","year":"2009"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-7-19"},{"key":"e_1_2_6_29_1","unstructured":"GSB Consulting & Communications.Role redesign primary care \u2013 shared care models of cancer treatment and surveillance post treatment: final report: Cancer Australia. GSB Sydney2010."},{"key":"e_1_2_6_30_1","unstructured":"ChomikTA.A report on shared care. Chomik Consulting Vancouver2005."},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61123-X"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2007.02141.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgq007"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1383"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2009.02508.x"},{"key":"e_1_2_6_36_1","unstructured":"Palliative Care Australia. A Guide to Palliative Care Service Development: a Population Based Approach. Canberra 2005"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951511000058"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajco.12047","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.12047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T16:44:27Z","timestamp":1696524267000},"score":7.5830083,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.12047"}},"issued":{"date-parts":[[2012,12,26]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/ajco.12047"],"URL":"https:\/\/doi.org\/10.1111\/ajco.12047","archive":["Portico"],"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"published":{"date-parts":[[2012,12,26]]}},{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:27:32Z","timestamp":1787160452966,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T00:00:00Z","timestamp":1615593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emerg Medicine Australasia"],"published-print":{"date-parts":[[2021,10]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n ED presentations because of illicit use of psychotropic drugs and pharmaceuticals result in significant medical harm and resource consumption. Patient assessment is complicated by the regular emergence of new psychoactive substances, difficulties associated with their identification and a lack of information about their effects. Here we report the protocol for the Emergency Department Admission Blood Psychoactive Testing (EDABPT) programme, an observational study utilising clinical data capture and definitive drug identification to assess the medical impact and patterns of illicit drug use in the community, and their geographic and temporal fluctuations. The study provides data to an early warning system targeting an improved public health response to emerging drugs of concern.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Enrolment of adult patients presenting with suspected illicit drug use occurs at four major EDs in a single urban setting. Clinical and demographic data are collected by treating clinicians. Blood samples are collected at presentation and frozen on site prior to transport to a specialised forensic facility for comprehensive toxicological screening.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Results are fed back to clinicians and disseminated more broadly via an existing local early warning system. Targeted warnings and public health releases are instigated where heightened risk or harm is identified.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The study pairs city\u2010wide patient enrolment with analytically confirmed toxicology results to allow broad sampling and identification of illicit drugs causing medical harm. It provides a mechanism for the identification of new agents as they emerge in the community, delivers a relevant and reliable source of information for public health agencies and clinicians and supplements existing local early warning mechanisms.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1742-6723.13752","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T13:17:22Z","timestamp":1615641442000},"page":"883-887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Establishing the protocols for the South Australian Emergency Department Admission Blood Psychoactive Testing (EDABPT) programme for drug surveillance"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6242-4480","authenticated-orcid":false,"given":"Emma","family":"Partridge","sequence":"first","affiliation":[{"name":"Forensic Science SA Adelaide South Australia Australia"},{"name":"College of Science and Engineering Flinders University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Alfred","sequence":"additional","affiliation":[{"name":"Emergency Department Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Camilleri","sequence":"additional","affiliation":[{"name":"Forensic Science SA Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Green","sequence":"additional","affiliation":[{"name":"Emergency Department Lyell McEwin Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Haustead","sequence":"additional","affiliation":[{"name":"Emergency Department Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"Emergency Department The Queen Elizabeth Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Kostakis","sequence":"additional","affiliation":[{"name":"Forensic Science SA Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Mallon","sequence":"additional","affiliation":[{"name":"Emergency Department Flinders Medical Centre Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerryn","family":"Mason","sequence":"additional","affiliation":[{"name":"Forensic Science SA Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April","family":"Rivers\u2010Kennedy","sequence":"additional","affiliation":[{"name":"Forensic Science SA Adelaide South Australia Australia"},{"name":"Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stockham","sequence":"additional","affiliation":[{"name":"Forensic Science SA Adelaide South Australia Australia"},{"name":"College of Science and Engineering Flinders University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,13]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"United Nations Office on Drugs and Crime.UNODC Early Warning Advisory on New Psychoactive Substances.2020. [Cited 29 Jul 2020.] Available from URL:https:\/\/www.unodc.org\/LSS\/Page\/NPS"},{"key":"e_1_2_9_3_1","unstructured":"Victorian Department of Justice and Community Safety.National Coronial Information System. [Cited 29 Jul 2020.] Available from URL:https:\/\/www.ncis.org.au\/"},{"key":"e_1_2_9_4_1","volume-title":"Illicit Drug Data Report 2017\u20132018","author":"Australian Criminal Intelligence Commission","year":"2019"},{"key":"e_1_2_9_5_1","unstructured":"PeacockA UporovaJ KarlssonAet al.Australian Drug Trends 2019: Key Findings from the National Illicit Drug Reporting System (IDRS) Interviews.2019. [Cited 29 Jul 2020.] Available from URL:https:\/\/ndarc.med.unsw.edu.au\/RESOURCE\/KEY\u2010FINDINGS\u20102019\u2010NATIONAL\u2010ILLICIT\u2010DRUG\u2010REPORTING\u2010SYSTEM\u2010IDRS\u2010INTERVIEWS"},{"key":"e_1_2_9_6_1","unstructured":"PeacockA KarlssonA UporovaJet al.Australian Drug Trends 2020: Key Findings from the National Ecstasy and Related Drugs Reporting System (EDRS) Interviews.2020. [Cited 29 Jul 2020.] Available from URL:https:\/\/ndarc.med.unsw.edu.au\/resource\/australian\u2010drug\u2010trends\u20102020\u2010key\u2010findings\u2010national\u2010ecstasy\u2010and\u2010related\u2010drugs\u2010reporting"},{"key":"e_1_2_9_7_1","volume-title":"National Wastewater Drug Monitoring Program\u2010Report 10","author":"Australian Criminal Intelligence Commission","year":"2020"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2009.088344"},{"key":"e_1_2_9_9_1","first-page":"779","article-title":"Survey of ICD\u201010 coding of hospital admissions in the UKdue to recreational drug toxicity","volume":"104","author":"Shah A","year":"2011","journal-title":"Int. J. Med."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.107825"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-018-0687-z"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-018-3756-8"},{"key":"e_1_2_9_13_1","unstructured":"World Health Organization.ICD\u201010: International Statistical Classification of Diseases and Related Health Problems 10th Revision.2020. [Cited 29 Jul 2020.] Available from URL:https:\/\/www.who.int\/classifications\/icd\/icdonlineversions\/en\/"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2014.02.022"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2016.1190980"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.13185"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14808"}],"container-title":["Emergency Medicine Australasia"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1742-6723.13752","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1742-6723.13752","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1742-6723.13752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T18:47:51Z","timestamp":1693334871000},"score":7.5829635,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1742-6723.13752"}},"issued":{"date-parts":[[2021,3,13]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/1742-6723.13752"],"URL":"https:\/\/doi.org\/10.1111\/1742-6723.13752","archive":["Portico"],"ISSN":["1742-6731","1742-6723"],"issn-type":[{"value":"1742-6731","type":"print"},{"value":"1742-6723","type":"electronic"}],"published":{"date-parts":[[2021,3,13]]},"assertion":[{"value":"2020-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:41:38Z","timestamp":1782538898626,"version":"3.54.5"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,1]]},"abstract":"\n Objective:<\/jats:title>\n To describe the presentation and management of lumbar bone stress injuries (LBSI), recurrent LBSI, and lumbar nonunited defects in elite Australian male and female cricket players.<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n Retrospective case series.<\/jats:p>\n <\/jats:sec>\n \n Setting:<\/jats:title>\n Professional domestic and international cricket teams over 13 seasons.<\/jats:p>\n <\/jats:sec>\n \n Participants:<\/jats:title>\n Elite Australian cricket players.<\/jats:p>\n <\/jats:sec>\n \n Independent variables:<\/jats:title>\n Symptomatic LBSI requiring time off cricket and lumbar nonunited defects, both confirmed by imaging.<\/jats:p>\n <\/jats:sec>\n \n Main outcome measures:<\/jats:title>\n Incidence, presentation, history, healing, and management.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n 211 LBSI were identified at an average incidence of 5.4 per 100 players per season. LBSI were most common in male pace bowlers younger than 20 years of age (58.1 per 100 players per season), however, were also observed in older players, females, and non-pace bowlers. Recurrent LBSI accounted for 33% (27%-40%) of all LBSI. Median days to return to match availability was 182 (128-251) days for all LBSI, with a shorter time frame observed for new and less severe injuries, and male spin bowlers. Healing was demonstrated in 87% (81%-91%) of all LBSI cases. 29 nonunited defects were identified and predisposed subsequent pain, LBSI, and spondylolisthesis.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n LBSI are experienced by approximately 5.4 in every 100 elite Australian cricket players per season, with a high time cost of approximately 4 to 8 months. Nonunited defects also have a high time cost with associated subsequent lumbar spine issues. The findings of this study reinforce the importance of early detection and conservative management of LBSI, particularly for younger male pace bowlers and players with recurrent LBSI, which may be supported by MRI.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/jsm.0000000000001132","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T18:01:29Z","timestamp":1677607289000},"page":"44-51","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Lumbar Bone Stress Injuries and Nonunited Defects in Elite Australian Cricket Players"],"prefix":"10.1097","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4461-2469","authenticated-orcid":false,"given":"Anna","family":"Saw","sequence":"first","affiliation":[{"name":"Cricket Australia, VIC, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Eales","sequence":"additional","affiliation":[{"name":"WA Cricket, WA, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Jones","sequence":"additional","affiliation":[{"name":"Cricket Australia, VIC, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Obst","sequence":"additional","affiliation":[{"name":"South Australian Cricket Association, SA, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Smith","sequence":"additional","affiliation":[{"name":"QSportsMedicine, QLD, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Kountouris","sequence":"additional","affiliation":[{"name":"Cricket Australia, VIC, Australia;"},{"name":"WA Cricket, WA, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Saw","sequence":"additional","affiliation":[{"name":"WA Cricket, WA, Australia;"},{"name":"Australian Institute of Sport, ACT, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"R1-20250528","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s40134-018-0299-z","article-title":"Management of lumbar spondylolysis in athletes: role of imaging","volume":"6","author":"Kountouris","year":"2018","journal-title":"Curr Radiol Rep."},{"key":"R2-20250528","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/s00586-015-4029-4","article-title":"Characteristics of lumbar spondylolysis in elementary school age children","volume":"25","author":"Sakai","year":"2016","journal-title":"Eur Spine J."},{"key":"R3-20250528","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1136\/bjsm.2003.006585","article-title":"Dissociation between back pain and bone stress reaction as measured by CT scan in young cricket fast bowlers","volume":"38","author":"Millson","year":"2004","journal-title":"Br J Sports Med."},{"key":"R4-20250528","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1136\/bjsports-2012-091337","article-title":"Injury in elite New Zealand cricketers 2002\u20132008: descriptive epidemiology","volume":"48","author":"Frost","year":"2014","journal-title":"Br J Sports Med."},{"key":"R5-20250528","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.jsams.2020.03.009","article-title":"Injuries in England and Wales elite men's domestic cricket: a nine season review from 2010 to 2018","volume":"23","author":"Goggins","year":"2020","journal-title":"J Sci Med Sport."},{"key":"R6-20250528","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ptsp.2011.01.002","article-title":"Lumbar vertebral stress injuries in fast bowlers: a review of prevalence and risk factors","volume":"213","author":"Johnson","year":"2012","journal-title":"Phys Ther Sport."},{"key":"R7-20250528","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2147\/OAJSM.S117497","article-title":"Incidence and prevalence of elite male cricket injuries using updated consensus definitions","volume":"7","author":"Orchard","year":"2016","journal-title":"Open Access J Sports Med."},{"key":"R8-20250528","doi-asserted-by":"crossref","first-page":"e000529","DOI":"10.1136\/bmjsem-2019-000529","article-title":"Incidence and prevalence of lumbar stress fracture in English County Cricket fast bowlers, association with bowling workload and seasonal variation","volume":"5","author":"Alway","year":"2019","journal-title":"BMJ Open Sport Exerc Med."},{"key":"R9-20250528","doi-asserted-by":"crossref","first-page":"108","DOI":"10.17159\/2078-516X\/2015\/v27i4a436","article-title":"Different tissue type categories of overuse injuries to cricket fast bowlers have different severity and incidence which varies with age","volume":"27","author":"Blanch","year":"2015","journal-title":"South Afr J Sports Med."},{"key":"R10-20250528","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.11124\/JBIES-21-00120","article-title":"Prevalence and incidence of injuries among female cricket players: a systematic review and meta-analysis","volume":"20","author":"Jacobs","year":"2022","journal-title":"JBI Evid Synth."},{"key":"R11-20250528","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.jsams.2019.05.013","article-title":"The incidence, prevalence, nature, severity and mechanisms of injury in elite female cricketers: a prospective cohort study","volume":"22","author":"Panagodage Perera","year":"2019","journal-title":"J Sci Med Sport."},{"key":"R12-20250528","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1055\/a-1192-5670","article-title":"Injury and player availability in women's international pathway cricket from 2015 to 2019","volume":"41","author":"Goggins","year":"2020","journal-title":"Int J Sports Med."},{"key":"R13-20250528","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1302\/0301-620X.92B12.24913","article-title":"Injuries to the lower back in elite fast bowlers: acute stress changes on MRI predict stress fracture","volume":"92-B","author":"Ranson","year":"2010","journal-title":"J Bone Joint Surg Br."},{"key":"R14-20250528","doi-asserted-by":"crossref","first-page":"115626","DOI":"10.1016\/j.bone.2020.115626","article-title":"Presence of bone marrow oedema in asymptomatic elite fast bowlers: implications for management","volume":"143","author":"Taylor","year":"2021","journal-title":"Bone"},{"key":"R15-20250528","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1136\/bjsports-2017-097930","article-title":"MRI bone marrow oedema precedes lumbar bone stress injury diagnosis in junior elite cricket fast bowlers","volume":"53","author":"Kountouris","year":"2019","journal-title":"Br J Sports Med."},{"key":"R16-20250528","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jsams.2020.06.018","article-title":"Radiological healing of lumbar spine stress fractures in elite cricket fast bowlers","volume":"24","author":"Singh","year":"2021","journal-title":"J Sci Med Sport."},{"key":"R17-20250528","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/BRS.0b013e3181c9f2a2","article-title":"Significance of magnetic resonance imaging signal change in the pedicle in the management of pediatric lumbar spondylolysis","volume":"35","author":"Sakai","year":"2010","journal-title":"Spine"},{"key":"R18-20250528","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1097\/JSM.0000000000000884","article-title":"Upper lumbar bone stress injuries in elite cricketers","volume":"32","author":"Saw","year":"2020","journal-title":"Clin J Sport Med."},{"key":"R19-20250528","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1136\/bjsports-2019-101969","article-title":"International Olympic Committee consensus statement: methods for recording and reporting of epidemiological data on injury and illness in sport 2020 (including STROBE Extension for Sport Injury and Illness Surveillance (STROBE-SIIS))","volume":"54","author":"Bahr","year":"2020","journal-title":"Br J Sports Med."},{"key":"R20-20250528","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1136\/bjsports-2019-101921","article-title":"Sport medicine diagnostic coding system (SMDCS) and the orchard sports injury and illness classification system (OSIICS): revised 2020 consensus versions","volume":"54","author":"Orchard","year":"2020","journal-title":"Br J Sports Med."},{"key":"R21-20250528","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/jbmr.412","article-title":"Bone mineral accrual from 8 to 30 years of age: an estimation of peak bone mass","volume":"26","author":"Baxter-Jones","year":"2011","journal-title":"J Bone Mineral Res."},{"key":"R22-20250528","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00198-008-0672-5","article-title":"Lumbar spine peak bone mass and bone turnover in men and women: a longitudinal study","volume":"20","author":"Walsh","year":"2009","journal-title":"Osteoporos Int."},{"key":"R23-20250528","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1136\/bjsm.2003.008110","article-title":"Comparing spondylolysis in cricketers and soccer players","volume":"38","author":"Gregory","year":"2004","journal-title":"Br J Sports Med."},{"key":"R24-20250528","article-title":"Characteristics of elite cricket fast bowlers who do and do not sustain a lumbar bone stress injury: multifactorial analysis over 4 years","author":"Lucente","year":"2022","journal-title":"J Sport Exer Sci."},{"key":"R25-20250528","first-page":"92","article-title":"Multiple risk factors associated with lumbar bone stress injury in youth cricket fast bowlers","volume":"5","author":"Sims","year":"2021","journal-title":"J Sport Exer Sci."},{"key":"R26-20250528","doi-asserted-by":"crossref","first-page":"e171769","DOI":"10.1001\/jamapediatrics.2017.1769","article-title":"Association between linear growth and bone accrual in a diverse cohort of children and adolescents","volume":"171","author":"McCormack","year":"2017","journal-title":"JAMA Pediatr."},{"key":"R27-20250528","doi-asserted-by":"crossref","first-page":"115163","DOI":"10.1016\/j.bone.2019.115163","article-title":"Age at attainment of peak bone mineral density and its associated factors: the National Health and Nutrition Examination Survey 2005\u20132014","volume":"131","author":"Xue","year":"2020","journal-title":"Bone"},{"key":"R28-20250528","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.bone.2019.07.030","article-title":"Lumbar bone mineral asymmetry in elite cricket fast bowlers","volume":"127","author":"Alway","year":"2019","journal-title":"Bone"},{"key":"R29-20250528","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1249\/MSS.0000000000002820","article-title":"Lumbar bone mineral adaptation: the effect of fast bowling technique in adolescent cricketers","volume":"54","author":"Keylock","year":"2021","journal-title":"Med Sci Sports Exer."},{"key":"R30-20250528","first-page":"1","article-title":"Bone health and asymmetry in elite female cricketers","author":"Alway","year":"2022","journal-title":"Eur J Sport Sci."},{"key":"R31-20250528","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1080\/02640414.2018.1522700","article-title":"Comparison of biomechanical characteristics between male and female elite fast bowlers","volume":"37","author":"Felton","year":"2019","journal-title":"J Sports Sci."},{"key":"R32-20250528","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1080\/02640410701275185","article-title":"Anthropometric characteristics of elite cricket fast bowlers","volume":"25","author":"Stuelcken","year":"2007","journal-title":"J Sports Sci."},{"key":"R33-20250528","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/jfmk6010017","article-title":"A comparison between male and female athletes in relative strength and power performances","volume":"6","author":"Bartolomei","year":"2021","journal-title":"J Funct Morphol Kinesiol."},{"key":"R34-20250528","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev.bioeng.8.061505.095721","article-title":"Biomechanical and molecular regulation of bone remodeling","volume":"8","author":"Robling","year":"2006","journal-title":"Annu Rev Biomed Eng."},{"key":"R35-20250528","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/2192568218823695","article-title":"The incidence of pars interarticularis defects in athletes","volume":"10","author":"Tawfik","year":"2020","journal-title":"Glob Spine J."}],"container-title":["Clinical Journal of Sport Medicine"],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/JSM.0000000000001132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T21:04:29Z","timestamp":1748466269000},"score":7.582949,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/JSM.0000000000001132"}},"issued":{"date-parts":[[2023,2,28]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1097\/jsm.0000000000001132","ISSN":["1050-642X"],"issn-type":[{"value":"1050-642X","type":"print"}],"published":{"date-parts":[[2023,2,28]]},"assertion":[{"value":"2022-07-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:32:35Z","timestamp":1767169955158,"version":"build-2238731810"},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"13_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,7,1]]},"abstract":"Abstract<\/jats:title>\n Rationale: Inflammatory myofibroblastic tumors (IMTs) are a particularly rare type of soft tissue sarcoma comprised of myofibroblastic spindle cells and an accompanying inflammatory infiltrate. There is an unmet clinical need for effective treatment regimens for patients diagnosed with IMT with anaplastic lymphoma kinase (ALK) rearrangement, who relapse following ALK inhibitor (ALKi) therapy or who present with aggressive disease. Fusion of RAN Binding Protein 2 (RANBP2) with ALK in IMT is associated with aggressive disease and has been correlated with tumor cell expression of CD30. This study investigated CD30 as a potential therapeutic target in IMT and the efficacy of the CD30-targeted antibody-monomethyl auristatin E conjugate, Brentuximab Vedotin (BV).<\/jats:p>\n Methods and Results: In a cohort of five recent IMT patients at the Sydney Children\u2019s Hospital, RANBP2-ALK fusion was identified in three patients (IMT1, IMT2 and IMT3) by RNA capture sequencing, while patients IMT4 and IMT5 (who did not relapse) harbored CLTC-ALK or SEC31A-ALK fusions respectively. Expression of CD30 was confirmed two of three RANBP2-ALK fusion positive tumors by immunohistochemistry. We established cell cultures and xenografts from malignant ascites of IMT1, at diagnosis (IMT1A) and at relapse (IMT1D) after treatment with ALKi\u2019s and low dose chemotherapy. CD30 expression was retained in the cell cultures and xenograft tumors, as demonstrated by flow cytometry and tumor histology. BV was investigated as a potential treatment for IMT with RANBP2-ALK fusion. BV reduced IMT1A and IMT1D cell viability in vitro in resazurin cell viability assays. IMT1A and IMT1D xenograft mice had a partial response to BV which significantly (p&lt;0.0001) prolonged survival compared to untreated controls. However, tumors eventually recurred. Resistance to BV correlated with upregulation of P-glycoprotein and reduced CD30 antigen expression in cells from treated IMT xenograft tumors. The combination of the ALK inhibitor crizotinib with BV has also been investigated. In vivo, the combination of crizotinib and BV resulted in complete resolution of tumor and significantly (p&lt;0.0001) improved survival compared to the individual agents.<\/jats:p>\n Conclusion: CD30 is a promising therapeutic target in RANBP2-ALK-rearranged IMT. BV successfully reduced IMT cell viability in vitro and prolonged survival in IMT xenografted mice, both as a single agent and when given in combination with crizotinib. Since BV is current clinical use for the treatment of Hodgkin lymphoma it may be possible to rapidly translate these findings into clinical practice for the treatment of IMT.<\/jats:p>\n Citation Format: Ashleigh M. Fordham, James Blackburn, Erin E. Heyer, Jinhan Xie, Emily V. Mould, Andrew J. Gifford, Lisa T. Morgan, Carol Wadham, Mitali Fadia, Jamie I. Fletcher, Karen L. MacKenzie, Toby N. Trahair. Targeting CD30 as a novel treatment strategy in RANBP2-ALK-rearranged inflammatory myofibroblastic tumor [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4824.<\/jats:p>","DOI":"10.1158\/1538-7445.am2019-4824","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T18:19:16Z","timestamp":1565201956000},"page":"4824-4824","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 4824: Targeting CD30 as a novel treatment strategy in\n RANBP2-ALK<\/i>\n -rearranged inflammatory myofibroblastic tumor"],"prefix":"10.1158","volume":"79","author":[{"given":"Ashleigh M.","family":"Fordham","sequence":"first","affiliation":[{"name":"1Children's Cancer Institute Australia, Randwick, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Blackburn","sequence":"additional","affiliation":[{"name":"2Garvan Institute of Medical Research, Darlinghurst, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin 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dose.<\/jats:p><\/jats:sec>Methods<\/jats:title>This prospective cohort study identified infective complication in patients who attended and subsequently underwent TRPB at the time of their one\u2010stop prostate clinic at our public tertiary hospital between August 2011 and April 2017. Patients who underwent TRPB between August 2011 and November 2014 received six doses of 500 mg of ciprofloxacin, taken twice daily over 3 days. This protocol was changed to a single dose of 500 mg of ciprofloxacin prior to biopsy from February 2015 to April 2017. Patients who had travelled to South East Asia in the 6 months prior to TRPB received a single dose of 1 g intravenous ertapenem prior to biopsy, and this remained unchanged throughout the study period. The rates of infective complication were recorded and compared between the groups of patients who had undergone six doses versus a single dose of prophylactic ciprofloxacin.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 766 patients underwent TRPB from August 2011 to April 2017. Of these, 357 patients received the 3\u2010day course of prophylaxis (Group 1) and 409 patients received the single dose prophylaxis (Group 2). Fifty\u2010five patients were excluded from analysis. There was no significant difference in infective complications between the two groups (3.4% (11\/326) Group 1 versus 4.9% (19\/385) Group 2, P<\/jats:italic> = 0.40).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our study supports the use of a single dose of ciprofloxacin as sufficient antibiotic prophylaxis prior to TRPB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.14360","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T06:16:53Z","timestamp":1515565013000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transrectal prostate biopsy sepsis rate following reduced quinolone antibiotic prophylaxis from six doses to single dose"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4037-240X","authenticated-orcid":false,"given":"Haider K.","family":"Bangash","sequence":"first","affiliation":[{"name":"UWA Medical School The University of Western Australia Perth Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Hawks","sequence":"additional","affiliation":[{"name":"UWA Medical School The University of Western Australia Perth Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve P.","family":"McCombie","sequence":"additional","affiliation":[{"name":"UWA Medical School The University of Western Australia Perth Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Brown","sequence":"additional","affiliation":[{"name":"UWA Medical School The University of Western Australia Perth Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dickon","family":"Hayne","sequence":"additional","affiliation":[{"name":"UWA Medical School The University of Western Australia Perth Western Australia Australia"},{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"CD006576","article-title":"Antibiotic prophylaxis for transrectal prostate biopsy","author":"Zani EL","year":"2011","journal-title":"Cochrane Database Syst. 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In the current study we asked whether: (a) training administered via a mobile phone\u2010based app could improve multitasking and (b) improved multitasking in the app would generalize to improved performance and situation awareness in a simulated air traffic control task (ATC). Participants completed the ATC task before and after multiple sessions of app\u2010based multitasking training or control training. Multitasking on the app improved across training sessions. However, this did not lead to improved performance or situation awareness, or workload reduction, relative to control training on the ATC task. These outcomes indicate that app\u2010based multitasking training based on repetition of a single training task will not necessarily yield generalizable benefits to human performance in other complex dynamic tasks.<\/jats:p>","DOI":"10.1002\/acp.3977","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T10:33:31Z","timestamp":1655462011000},"page":"874-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effect of multi\u2010tasking training on performance, situation awareness, and workload in simulated air traffic control"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9321-745X","authenticated-orcid":false,"given":"Stephanie C.","family":"Black","sequence":"first","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela D.","family":"Bender","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"},{"name":"Department of Defence Defence Science and Technology Group South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susannah J.","family":"Whitney","sequence":"additional","affiliation":[{"name":"Department of Defence Defence Science and Technology Group South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayne","family":"Loft","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troy A. 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This public health issue warrants further research attention to help inform the development of prevention and intervention efforts. Our study is the first to characterize suicidality (i.e., suicidal ideation\/suicide attempt) and explore associated risk factors in young individuals with FASD within the Australian context.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Retrospective file reviews from a diagnostic clinic in Western Australia obtained data on demographic variables and risk factors, including psychosocial stressors (i.e., child protection and justice system involvement, history of abuse\/neglect) and comorbid diagnoses (i.e., attention\u2010deficit\u2010hyperactivity disorder (ADHD), attachment disorder, conduct disorder, anxiety disorder, depression, substance use disorder, and sleep disorder). Data on suicidality were collected via formal suicide risk assessments and source documentation.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One hundred and ninety\u2010five participants diagnosed with FASD were included in the study (\n M<\/jats:italic>\n age<\/jats:sub>\n \u2009=\u200911.75\u2009years, range\u2009=\u20095\u201321\u2009years). Of these, 40 (21%) reported suicidality, with the youngest being 5\u2009years old. There was a significant positive correlation between suicidality and age. A greater proportion of individuals with FASD who had been involved with the justice system (\n n<\/jats:italic>\n \u2009=\u200930, 35%) reported suicidality. Participants with attachment disorder (\n n<\/jats:italic>\n \u2009=\u200919, 34%), conduct disorder (\n n<\/jats:italic>\n \u2009=\u200910, 40%), substance use disorder (\n n<\/jats:italic>\n \u2009=\u200914, 50%), and depression (\n n<\/jats:italic>\n \u2009=\u200912, 60%) had significantly higher rates of suicidality than individuals without these comorbidities. The risk of suicidality increased in participants with comorbid depression (OR\u2009=\u20094.20) after controlling for age as a covariate.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n These findings add to the growing body of evidence that highlights the vulnerability of individuals with FASD to suicidality compared with the general population, underscoring the need for targeted, culturally safe suicide intervention\/prevention efforts.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/acer.70039","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T01:04:27Z","timestamp":1742432667000},"page":"1149-1160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of risk factors associated with suicidality in children and adolescents with fetal alcohol spectrum disorder in Western Australia"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2727-1471","authenticated-orcid":false,"given":"Grace Kuen Yee","family":"Tan","sequence":"first","affiliation":[{"name":"School of Psychological Science University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3884-4084","authenticated-orcid":false,"given":"Sophia G.","family":"Connor","sequence":"additional","affiliation":[{"name":"School of Medicine University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunee","family":"Quinn","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0384-3233","authenticated-orcid":false,"given":"James","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"School of Psychological Science and Patches Australia University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Adams","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Perth Children's Hospital Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1737-7774","authenticated-orcid":false,"given":"Carmela F.","family":"Pestell","sequence":"additional","affiliation":[{"name":"School of Psychological Science University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcap.12295"},{"key":"e_1_2_10_4_1","unstructured":"Australian Bureau of Statistics. 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This article describes the views of staff working in three mainstream out\u2010of\u2010home care organisations, where children are cared for by non\u2010Indigenous foster carers. Through the lenses of recovery and justice capital, we explore the cultural assets and resources that are made available to non\u2010Indigenous foster carers providing care for children, as well as the institutional elements that either inhibit or facilitate cultural connection and activities. We argue that the inclusion of Aboriginal and Torres Strait Islander voices when ascertaining information about children's culture and connection is critical to ensuring best cultural practice. 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The beer is refermented for a minimum of 2 weeks before distribution, with the physiological state of the yeast a critical factor for successful refermentation. Ideally, fresh yeast that is propagated from a dedicated propagation plant should be used for refermentation in bottles. Here, we explored the applicability of the fluorescent and redox\u2010sensitive dye, resazurin, to assess cellular metabolism in yeast and its ability to differentiate between growth stages. We applied this assay, with other markers of yeast physiology, to evaluate yeast quality during a full\u2010scale industrial propagation. Resazurin allowed the discrimination between the different growth phases in yeast and afforded a more in\u2010depth understanding of yeast metabolism during propagation. 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a hybrid closed loop (HCL) system in restoring hypoglycemia awareness in individuals with impaired awareness of hypoglycemia (IAH).<\/jats:p>\n <\/jats:sec>\n \n Research Design and Methods:<\/jats:title>\n Participants with IAH (Gold score \u22654) were recruited into a randomized crossover pilot study. They participated in two 8-week periods using a HCL system (Medtronic 670G\u2122) (intervention) and standard insulin pump therapy (control). Hyperinsulinemic hypoglycemic clamp studies were undertaken at baseline and at the end of each study period for the evaluation of the counter-regulatory hormonal and symptomatic responses to hypoglycemia.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Seventeen participants (mean age [standard deviation] 35.8 years [11.2 years]) were included in the study. Peak epinephrine levels (median, interquartile range [IQR]) in response to hypoglycemia were similar postintervention and control periods; 234.7\u2009pmol\/L (109.2; 938.9) versus 188.3\u2009pmol\/L (133.7; 402.9),\n P<\/jats:italic>\n \u2009=\u20090.233. However, both peak adrenergic and neuroglycopenic symptom scores were higher after intervention; 5.0 (4.5; 9.0) versus 4.0 (4.0; 5.5),\n P<\/jats:italic>\n \u2009=\u20090.009, and 8.5 (6.0; 15.0) versus 6.5 (6.0; 7.0)\n P<\/jats:italic>\n \u2009=\u20090.014, respectively. Self-reported hypoglycemia awareness improved: median (IQR) Gold score was 4.0 (3.0; 5.5) versus 5.5 (4.5; 6.0); intervention versus control,\n P<\/jats:italic>\n \u2009=\u20090.033. Time spent <3.9 and <3.0\u2009mmol\/L was lower in the intervention group than in control,\n P<\/jats:italic>\n \u2009=\u20090.002. Other patient-reported outcomes (hypoglycemia fear and diabetes treatment satisfaction) did not change.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n A short-term use of a HCL system failed to demonstrate an improvement in counter-regulatory hormonal responses. However, higher hypoglycemia symptom scores during controlled hypoglycemia, better self-reported hypoglycemia awareness, and less time spent in hypoglycemia suggest the potential benefits of a HCL system in people with IAH.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration:<\/jats:title>\n \n anzctr.org.au<\/jats:uri>\n Identifier: ACTRN12616000909426.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/dia.2020.0593","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T15:59:28Z","timestamp":1612799968000},"page":"482-490","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Impact of Hybrid Closed Loop Therapy on Hypoglycemia Awareness in Individuals with Type 1 Diabetes and Impaired Hypoglycemia Awareness"],"prefix":"10.1177","volume":"23","author":[{"given":"Marie-Anne","family":"Burckhardt","sequence":"first","affiliation":[{"name":"Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia."},{"name":"Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, Western Australia, Australia."},{"name":"Division of Paediatrics, Medical School, The University of Western Australia, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary B.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia."},{"name":"Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, Western Australia, Australia."},{"name":"Division of Paediatrics, Medical School, The University of Western Australia, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Dart","sequence":"additional","affiliation":[{"name":"Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia."},{"name":"Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirubasini","family":"Paramalingam","sequence":"additional","affiliation":[{"name":"Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia."},{"name":"Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, Western Australia, Australia."},{"name":"Division of Paediatrics, Medical School, The University of Western Australia, Perth, Western Australia, 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Western Australia, Perth, Western Australia, Australia."},{"name":"Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, Western Australia, Australia."},{"name":"Division of Paediatrics, Medical School, The University of Western Australia, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia."},{"name":"Department of Endocrinology and Diabetes, Perth Children's Hospital, Perth, Western Australia, Australia."},{"name":"Division of Paediatrics, Medical School, The University of Western Australia, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.12.1691"},{"key":"e_1_3_5_3_2","first-page":"1187","article-title":"Severe hypoglycemia in youth with insulin-dependent diabetes mellitus: frequency and causative factors","volume":"88","author":"Bhatia V","year":"1991","unstructured":"Bhatia V, , Wolfsdorf JI: Severe hypoglycemia in youth with insulin-dependent diabetes mellitus: frequency and causative factors. Pediatrics, 1991; 88:1187\u20131193.","journal-title":"Pediatrics"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(10)70470-5"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12460"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02413.x"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.11.1939"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91336-6"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.17.7.697"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.11.1683"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-1245"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.4.637"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1207\/s15327558ijbm1104_4"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2015.08.004"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1042"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-1004"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30193-0"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13561"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0030"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.277818"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30150-0"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509351"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32567-3"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2016.0421"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2019.0018"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.11708"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.7.901"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2010"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.16.2.519"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.18.4.517"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1343"},{"key":"e_1_3_5_32_2","first-page":"111","volume-title":"Handbook of Psychology and Diabetes","author":"Bradley C","year":"1994","unstructured":"Bradley C: Diabetes Treatment Satisfaction Questionnaire (DTSQ). In: Bradley C, ed. Handbook of Psychology and Diabetes. Chur (Switzerland); Harwood Academic Publishers, 1994, pp. 111\u2013132."},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1600"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.2307\/2528104"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13304"},{"issue":"9","key":"e_1_3_5_36_2","first-page":"729","article-title":"Avoidance of hypoglycemia restores hypoglycemia awareness by increasing beta-adrenergic sensitivity in type 1 diabetes. Ann Intern Med","volume":"134","author":"Fritsche A","year":"2001","unstructured":"Fritsche A, , Stefan N, , Haring H, et al.: Avoidance of hypoglycemia restores hypoglycemia awareness by increasing beta-adrenergic sensitivity in type 1 diabetes. Ann Intern Med. May 1, 2001; 134(9 Pt 1):729\u2013736.","journal-title":"May 1"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-2682"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30297-6"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278576"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12962"}],"container-title":["Diabetes Technology & Therapeutics"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/dia.2020.0593","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dia.2020.0593","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dia.2020.0593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:13:03Z","timestamp":1777399983000},"score":7.581871,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/dia.2020.0593"}},"issued":{"date-parts":[[2021,6,29]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1089\/dia.2020.0593"],"URL":"https:\/\/doi.org\/10.1089\/dia.2020.0593","ISSN":["1520-9156","1557-8593"],"issn-type":[{"value":"1520-9156","type":"print"},{"value":"1557-8593","type":"electronic"}],"published":{"date-parts":[[2021,6,29]]}},{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T22:07:16Z","timestamp":1769897236547,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2025,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n To review the literature to identify key issues causing variation in clinical practice, assess the knowledge gap, and develop a standardised pathway for managing upper airway obstruction (UAO) in infants with Robin sequence (RS).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The tripartite framework of evidence\u2010based practice, which included a systematic review of the literature, extensive consultation with a multidisciplinary team of experts, and feedback from the patients was used.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of the 2672 articles from the initial search, 66 were studied in detail. We identified five pivotal issues prevalent while managing UAO in RS. These issues were addressed systematically to develop an adaptable stepwise standardised pathway. The main pillars of the pathway are (a) early objective assessment of the severity of UAO using polysomnography, (b) graded treatment approach based on centre\u2010specific preferences, (c) early and regular multidisciplinary team discussions and (d) clearly defined criteria for treatment escalation or cessation, discharge and follow\u2010up.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This unique pathway is based on available evidence, consensus of experts and parents' feedback. It provides a stepwise guide to the clinician for the management of UAO in infants with RS, adaptability for centre\u2010specific treatment preferences and framework for future comparisons of different treatments.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apa.70028","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T06:10:22Z","timestamp":1739427022000},"page":"1760-1777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Robin Sequence: From Dilemmas to Developing an Adaptable Standardized Stepwise Approach"],"prefix":"10.1111","volume":"114","author":[{"given":"Dimple","family":"Goel","sequence":"first","affiliation":[{"name":"Neonatology Perth Children's Hospital Nedlands Western Australia Australia"},{"name":"Respiratory and Sleep Perth Children's Hospital Nedlands Western Australia Australia"},{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Wilson","sequence":"additional","affiliation":[{"name":"Respiratory and Sleep Perth Children's Hospital Nedlands Western Australia Australia"},{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shripada","family":"Rao","sequence":"additional","affiliation":[{"name":"Neonatology Perth Children's Hospital Nedlands Western Australia Australia"},{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gillett","sequence":"additional","affiliation":[{"name":"Plastic Surgery Perth Children's Hospital Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Hayley Herbert","sequence":"additional","affiliation":[{"name":"Ear Nose Throat Perth Children's Hospital Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"Respiratory and Sleep Perth Children's Hospital Nedlands Western Australia Australia"},{"name":"University of Western Australia Crawley Western Australia 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This phase Ib\/II study evaluated the safety and efficacy of the combination of irinotecan, panitumumab, and everolimus.<\/jats:p>\n Patients and Methods: Patients with KRAS exon 2 wild-type (WT) mCRC following failure of fluoropyrimidine-based therapy received i.v. irinotecan and panitumumab every 2 weeks, and everolimus orally throughout a 14-day cycle. The primary endpoint of the phase II study was response rate (RR). Secondary survival outcomes were calculated using the Kaplan\u2013Meier method, and results were analyzed as intention to treat. A preplanned exploratory biomarker analysis was performed.<\/jats:p>\n Results: Forty-nine patients were enrolled. Dose level 1 (irinotecan 200 mg\/m2, panitumumab 6 mg\/kg, and everolimus 5 mg alternate day) was declared the MTD with no dose-limiting toxicities in six patients. Forty patients were treated at dose level 1: median age, 60 years (37\u201376); 65% male; 45% and 52.5%, respectively, with Eastern Cooperative Oncology Group values of 0\/1. Median dose intensity was 85%. Grade 3 toxicities were diarrhea (23%), mucositis (18%), rash (13%), fatigue (8%), dehydration (5%), neutropenia (20%), febrile neutropenia (8%), hypomagnesemia (20%), and hypokalemia (8%). Grade 4 toxicities were hypomagnesemia (5%) and neutropenia (3%). RR was 48%, and stable disease was 43%. Median progression-free survival (PFS) was 5.6 months, and median overall survival (OS) was 10.8 months. Twenty-five patients were RAS\/RAF WT and had an RR of 60%, median PFS of 6.4 months, and OS of 11.8 months.<\/jats:p>\n Conclusions: The toxicity of the panitumumab, irinotecan, and everolimus regimen is as expected and manageable. The RR of 60% in all RAS\/RAF WT supports further study of this combination. Clin Cancer Res; 24(16); 3838\u201344. \u00a92018 AACR.<\/jats:p>","DOI":"10.1158\/1078-0432.ccr-17-3590","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T09:15:32Z","timestamp":1525770932000},"page":"3838-3844","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Phase IB\/II Study of Second-Line Therapy with Panitumumab, Irinotecan, and Everolimus (PIE) in\n KRAS<\/i>\n Wild-Type Metastatic Colorectal Cancer"],"prefix":"10.1158","volume":"24","author":[{"given":"Amanda","family":"Townsend","sequence":"first","affiliation":[{"name":"1The Queen Elizabeth Hospital, Adelaide, South Australia, Australia."},{"name":"2University of Adelaide, Adelaide, South Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall","family":"Tebbutt","sequence":"additional","affiliation":[{"name":"3Heidelberg Repatriation Hospital Olivia Newton-John Cancer Wellness & 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It further identifies a number of key themes which flow from that observation and which are important to configuring psychology education in a way which takes account of emerging trends. The major theme identified in the research is the importance of breadth. The theme of the importance of breadth takes two related and repeated forms. The first is that graduates need to be thinkers rather than doers. The second is that employers in the human services stress the need for broad-based thinking and analytical skills to reflect social and contextual awareness of therapeutic situations and human service programmes and interventions. Stakeholders broadly commented that graduates seeking employment in the human service sector need upskilling in terms of a contextual awareness of the \u2018real world\u2019. One idea which emerged in this research is that real-world multidisciplinarity is best underpinned by an interdisciplinary approach to teaching and learning. <\/jats:p>","DOI":"10.2304\/plat.2013.12.2.159","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T12:29:19Z","timestamp":1375187359000},"page":"159-167","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Interdisciplinarity and Undergraduate Psychology Education"],"prefix":"10.1177","volume":"12","author":[{"given":"Ian","family":"Goodwin-Smith","sequence":"first","affiliation":[{"name":"University of Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elissa","family":"Pearson","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"Ranzijn","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Campbell","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Lushington","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"volume-title":"Social work education and accreditation standards","year":"2008","author":"Australian Association of Social Workers","key":"bibr1-plat.2013.12.2.159"},{"unstructured":"Government Australian. 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Retrieved from http:\/\/www.nhwt.gov.au\/documents\/Mental%20Health%20Workforce%20Activities\/MHWAC%20Supply%20of%20psychologists.pdf.","key":"bibr15-plat.2013.12.2.159"},{"doi-asserted-by":"publisher","key":"bibr16-plat.2013.12.2.159","DOI":"10.1027\/1015-5759.22.1.28"}],"container-title":["Psychology Learning & Teaching"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2304\/plat.2013.12.2.159","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2304\/plat.2013.12.2.159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T01:32:33Z","timestamp":1741656753000},"score":7.581429,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2304\/plat.2013.12.2.159"}},"issued":{"date-parts":[[2013,1,1]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.2304\/plat.2013.12.2.159"],"URL":"https:\/\/doi.org\/10.2304\/plat.2013.12.2.159","ISSN":["1475-7257","2057-3022"],"issn-type":[{"type":"print","value":"1475-7257"},{"type":"electronic","value":"2057-3022"}],"published":{"date-parts":[[2013,1,1]]}},{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:37:42Z","timestamp":1784122662967,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n Mental\u2010health issues accounted for 418 million disability\u2010adjusted life years in 2019, costing the world economy approximately $5 trillion. Untreated hearing loss is a well\u2010known modifiable risk factor for mental\u2010health issues, with severe\u2010to\u2010profound hearing loss having the largest impact. Therefore, treatment of severe\u2010to\u2010profound hearing loss, namely with cochlear implantation, could help to alleviate psychological distress. However, previous studies have failed to include comprehensive measures of mental health or adequate controls. The current study thus aimed to conduct a controlled, longitudinal investigation of how cochlear implantation affects depression, anxiety and stress levels.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Participants were 87 adults assigned to conditions based on hearing status: normal hearing (\n n<\/jats:italic>\n \u2009=\u200944), received cochlear implant (\n n<\/jats:italic>\n \u2009=\u200926) or untreated hearing loss (\n n<\/jats:italic>\n \u2009=\u200917).\n <\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n The short\u2010form Depression Anxiety Stress Scale was given at four timepoints (baseline, 3\u2009months, 6\u2009months, 12\u2009months). Data were analysed using linear mixed\u2010effects modelling.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Results showed that cochlear implants helped to stabilise anxiety and stress symptoms, while depression symptoms were observed to worsen over time despite treatment.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our findings suggest that treatment of severe\u2010to\u2010profound hearing loss with cochlear implantation was associated with a lessening of anxiety and stress scores, although the clinical significance of such changes remains uncertain. Due to the current study's non\u2010randomised treatment allocation, future randomised controlled trials are required for confirmation. The present findings help inform clinical and societal interventions for mental\u2010health issues associated with hearing loss.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/coa.14326","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T02:45:03Z","timestamp":1745981103000},"page":"848-855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Severe\u2010to\u2010Profound Hearing Loss and Mental Health: Initial Evidence That Cochlear Implantation Helps Alleviate Symptoms of Anxiety and Stress"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4480-2406","authenticated-orcid":false,"given":"Paul","family":"McIlhiney","sequence":"first","affiliation":[{"name":"Ear Science Institute Australia Subiaco Western Australia Australia"},{"name":"Department of Psychological Sciences The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8689-6199","authenticated-orcid":false,"given":"Osvaldo P.","family":"Almeida","sequence":"additional","affiliation":[{"name":"UWA Medical School The University of Western Australia Crawley Western Australia Australia"},{"name":"WA Centre for Health and Ageing The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0588-4402","authenticated-orcid":false,"given":"Catherine M.","family":"Sucher","sequence":"additional","affiliation":[{"name":"Ear Science Institute Australia Subiaco Western Australia Australia"},{"name":"Centre for Ear Sciences The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2911-5381","authenticated-orcid":false,"given":"Robert H.","family":"Eikelboom","sequence":"additional","affiliation":[{"name":"Ear Science Institute Australia Subiaco Western Australia Australia"},{"name":"Centre for Ear Sciences The University of Western Australia Crawley Western Australia Australia"},{"name":"Curtin Medical School Curtin University Bentley Western Australia Australia"},{"name":"Department of Speech Language Pathology and Audiology University of Pretoria Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5814-4355","authenticated-orcid":false,"given":"Dona M. 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Otolaryngology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.14326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T08:02:13Z","timestamp":1754294533000},"score":7.581279,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.14326"}},"issued":{"date-parts":[[2025,4,29]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/coa.14326"],"URL":"https:\/\/doi.org\/10.1111\/coa.14326","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.14326\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14326\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14326\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14326\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14326\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14326\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14326\/v3\/response1","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"published":{"date-parts":[[2025,4,29]]},"assertion":[{"value":"2023-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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Modeling"],"prefix":"10.1061","author":[{"given":"Mark L.","family":"Stephens","sequence":"first","affiliation":[{"name":"The University of Adelaide, Adelaide, South Australia (Australia)."},{"name":"The University of Adelaide, Adelaide, South Australia (Australia)."},{"name":"The University of Adelaide, Adelaide, South Australia (Australia)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus R.","family":"Simpson","sequence":"additional","affiliation":[{"name":"The University of Adelaide, Adelaide, South Australia (Australia)."},{"name":"The University of Adelaide, Adelaide, South Australia (Australia)."},{"name":"The University of Adelaide, Adelaide, South Australia (Australia)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin F.","family":"Lambert","sequence":"additional","affiliation":[{"name":"The University of Adelaide, Adelaide, South Australia (Australia)."},{"name":"The University of Adelaide, Adelaide, South Australia 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How adding CEM and MRI to CI might change the surgical plan is understudied.<\/jats:p><\/jats:sec>Methods<\/jats:title>Surgical plans (breast conserving surgery (BCS), wider BCS, BCS with diagnostic excision (>1BCS), mastectomy) were devised by mock\u2010MDT (radiologist, surgeon and pathology reports) according to disease extent on CI, CI\u2009+\u2009CEM and CI\u2009+\u2009MRI. Differences in the mock\u2010MDT's surgical plans following the addition of CEM or MRI were investigated. Using pre\u2010defined criteria, the appropriateness of the modified plans was assessed by comparing estimated disease extent on imaging with final pathology. Surgery performed was recorded from patient records.<\/jats:p><\/jats:sec>Results<\/jats:title>Contrast imaging modified mock\u2010MDT plans for 20 of 61(32.8%) breasts. The addition of CEM changed the plan in 16\/20 (80%) and MRI in 17\/20 breasts (85%). Identical changes were proposed by both CEM and MRI in 13\/20 (65%) breasts. The modified surgical plan based on CI\u2009+\u2009CEM was possibly appropriate for 6\/16 (37.5%), and CI\u2009+\u2009MRI in 9\/17, (52.9%) breasts. The surgery performed was concordant with the mock\u2010MDT plan for all 10 patients where the plans could be compared (BCS 1, >1 BCS 2 and mastectomy 7).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Adding CEM or MRI to CI changed mock\u2010MDT plans in up to one third of women, but not all were appropriate. Changing surgical plans following addition of contrast imaging to CI without biopsy confirmation could lead to over or under\u2010treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18583","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T03:22:17Z","timestamp":1689218537000},"page":"2197-2202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interpreting contrast imaging to plan breast surgery"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1481-1141","authenticated-orcid":false,"given":"Donna B.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Royal Perth Hospital Perth Western Australia Australia"},{"name":"Medical School University of Western Australia Perth Western Australia Australia"},{"name":"BreastScreen WA Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max M.","family":"Hobbs","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2896-9089","authenticated-orcid":false,"given":"Maxine Mariri","family":"Ronald","sequence":"additional","affiliation":[{"name":"Department of Surgery Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Burrows","sequence":"additional","affiliation":[{"name":"Medical School University of Western Australia Perth Western Australia Australia"},{"name":"Royal Perth Hospital Research Foundation Perth Western Australia 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.03257"},{"key":"e_1_2_10_3_1","volume-title":"Consensus Guideline on Diagnostic and Screening Magnetic Resonance Imaging of the Breast [Online]","author":"Committee 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(Australia)","year":"2007"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-08240-x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2018.21.e62"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12121084"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.10705"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20211172"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4650-6"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.893018"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08832-2"}],"container-title":["ANZ Journal of Surgery"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.18583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:10:29Z","timestamp":1694754629000},"score":7.580615,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.18583"}},"issued":{"date-parts":[[2023,7,12]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/ans.18583"],"URL":"https:\/\/doi.org\/10.1111\/ans.18583","archive":["Portico"],"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"published":{"date-parts":[[2023,7,12]]},"assertion":[{"value":"2023-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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administration of intravesical bacillus Calmette\u2013Guerin (BCG) for non\u2010muscle\u2010invasive bladder cancer (NMIBC).<\/jats:p><\/jats:sec>Subjects and methods<\/jats:title>A multicenter retrospective review was conducted among 83 patients undergoing Fremantle protocol intravesical BCG for NMIBC within 4 major hospitals in Western Australia between January 2016 and December 2018. The Fremantle protocol consists of weekly BCG instillations for 6 weeks during the induction phase, followed by monthly BCG instillations for 10 months during the maintenance phase with integrated clearance\u2010to\u2010proceed algorithms for urine MSU checks, flexible cystoscopies performed at 3 monthly intervals during maintenance BCG, and repeat GA cystoscopies with four quadrant bladder biopsies routinely obtained following the completion of induction and maintenance treatment.<\/jats:p><\/jats:sec>Results<\/jats:title>For patients undergoing Fremantle protocol BCG, 98.8% (82\/83) and 75.9% (63\/83) of patients completed their induction and maintenance courses of BCG, respectively. Induction BCG was delivered over a median duration of 35 days (range 34\u201384 days), and maintenance BCG was delivered over a median duration of 266 days (range 1\u2013682 days). The tumor recurrence rate was 10.8% (9\/83) at the time of post\u2010induction biopsies, 2.4% (2\/83) during maintenance treatment, 0% (0\/60) at the time of post\u2010maintenance biopsies, and 8.8% (5\/57) after a median further follow\u2010up of 16 months (range 0\u201351 months).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The Fremantle protocol appears to be a safe and effective BCG regimen with several advantages over other BCG protocols, including high completion rates, low recurrence rates, and being highly pragmatic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13933","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T06:05:00Z","timestamp":1674194700000},"page":"697-705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fremantle protocol: Multicenter clinical outcomes for a pragmatic protocol for intravesical bacillus Calmette\u2013Guerin"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5430-729X","authenticated-orcid":false,"given":"Kuok Liang","family":"Tan","sequence":"first","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pravin","family":"Viswambaram","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"McCombie","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Moe","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4094-401X","authenticated-orcid":false,"given":"Dickon","family":"Hayne","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464\u2010410x.2001.02306.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20105347(05)64273\u20105"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.08.016"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.09.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20105347(02)80294\u20104"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.08.122"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.05.027"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67707-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.10.039"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2017.1326889"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(05)70472\u20101"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.02.022"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010015\u20101431\u20106"},{"key":"e_1_2_9_15_1","unstructured":"Department 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2011:16p.https:\/\/www.healthywa.wa.gov.au\/\u2010\/media\/Files\/Corporate\/general\u2010documents\/Health\u2010Networks\/WA\u2010Cancer\u2010and\u2010Palliative\u2010Care\/Cancer\/Intravesial\u2010BGD\u2010clinical\u2010care\u2010pathway.pdf"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.05.033"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.3.441"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2003.04764.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.02.040"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442\u20102042.2010.02584.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20105347(05)66333\u20101"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u2010410X.2010.09891.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/1078\u20101439(95)00041\u2010F"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950115)75:2<552::AID-CNCR2820750219>3.0.CO;2-H"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110243251703"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13102"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13939"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894\u2010016\u20100126\u2010x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2003.12.016"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.08.022"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64044-X"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00689-0"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13933","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajco.13933","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T23:17:28Z","timestamp":1700608648000},"score":7.5801444,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.13933"}},"issued":{"date-parts":[[2023,1,19]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/ajco.13933"],"URL":"https:\/\/doi.org\/10.1111\/ajco.13933","archive":["Portico"],"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"published":{"date-parts":[[2023,1,19]]},"assertion":[{"value":"2021-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:11:30Z","timestamp":1759972290585,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2024,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Interplay between diet, depression, and Alzheimer's disease (AD) shows promise as an important area of study for early intervention and therapy. Associations between both depression and diet and heightened AD risk underscore the need to examine the moderating effect of dietary patterns on the relationship between depression, and AD\u2010related blood\u2010based biomarkers.<\/jats:p><\/jats:sec>Method<\/jats:title>Data from cognitively unimpaired older adults (n=89; age \u226560 years) enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study were included. Participants completed a food frequency questionnaire, self\u2010report measures of depression, and had AD\u2010related blood\u2010based biomarker levels for phosphorylated tau (ptau181) 181, A\u03b240, A\u03b242, Neurofilament Light Chain (NfL), and Glial Fibrillary Acidic Protein (GFAP). Scores for two dietary patterns, 1) Mediterranean diet (MeDi), and 2) western diet were generated for each individual. Moderation and simple slope analyses were used to examine the interactions between dietary patterns, depression, and biomarker levels.<\/jats:p><\/jats:sec>Result<\/jats:title>Depression was positively associated with NfL levels in males with lower than mean MeDi score adherence (\u03b2=3.759, SE=1.248, p=0.005). Depression was also positively associated with NfL levels in Apolipoprotein E (APOE) \u03b54 allele non\u2010carriers with lower than mean and mean MeDi score adherence (\u03b2=7.384, SE=1.972, p<0.001; \u03b2=3.797, SE=1.004, p<0.001, respectively).<\/jats:p>Moreover, depression was positively associated with A\u03b240 levels in APOE \u03b54 allele non\u2010carriers with lower than mean and mean MeDi score adherence (\u03b2=16.837, SE=5.242, p=0.002; \u03b2=7.502, SE=2.669, p=0.005, respectively).<\/jats:p>No moderating effects of MeDi on the relationship between depression and levels of ptau181, A\u03b242, and GFAP were observed. Furthermore, western diet had no moderating effect on the relationship between depression, and AD\u2010related blood\u2010based biomarkers.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study highlights MeDi adherence as a potential moderator of the relationship between mood and AD\u2010related blood\u2010based biomarker levels. These findings also emphasize the importance of gender\u2010 and genotype\u2010specific approaches to depression\u2010cognition\u2010diet research and highlight the need for further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.091148","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:48:11Z","timestamp":1736405291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The moderating effect of diet on the relationship between depression and Alzheimer\u2019s disease\u2010related blood\u2010based biomarker"],"prefix":"10.1002","volume":"20","author":[{"given":"Hilal Salim Al","family":"Shamsi","sequence":"first","affiliation":[{"name":"ECU university, Joondalup, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha L","family":"Gardener","sequence":"additional","affiliation":[{"name":"Murdoch University, Perth, Western Australia Australia"},{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Alzheimer's Research Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie Rainey","family":"Smith","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Edith Cowan University, Joondalup, Western Australia Australia"},{"name":"Centre for Healthy Ageing, Murdoch University, Murdoch, Western Australia Australia"},{"name":"Centre of Excellence for Alzheimer\u2019s Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia Australia"},{"name":"Australian Alzheimer's Research Foundation, Nedlands, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid R.","family":"Sohrabi","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Alzheimer's Research Australia, Perth, Western Australia Australia"},{"name":"Murdoch University, Murdoch, Western Australia Australia"},{"name":"Department of Biomedical Sciences, Macquarie University, Sydney, NSW Australia"},{"name":"Centre for Healthy Ageing, Murdoch University, Murdoch, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warnakulasuriya Mary Ann Dipika Binosha","family":"Fernando","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Centre of Excellence for Alzheimer\u2019s Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia Australia"},{"name":"Australian Alzheimer\u2019s Research Foundation, Perth, Western Australia Australia"},{"name":"Edith Cowan University, Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph N","family":"Martins","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Perth, Western Australia Australia"},{"name":"Alzheimer's Research Australia, Perth, Western Australia Australia"},{"name":"McCusker Alzheimer\u2019s Research Foundation, Perth, Western Australia Australia"},{"name":"Macquarie University, Sydney, NSW Australia"},{"name":"Centre for Ageing, Cognition and Wellbeing, Macquarie University, North Ryde, NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,9]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.091148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:10:51Z","timestamp":1759957851000},"score":7.5801177,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.091148"}},"issued":{"date-parts":[[2024,12]]},"references-count":0,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/alz.091148"],"URL":"https:\/\/doi.org\/10.1002\/alz.091148","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"type":"print","value":"1552-5260"},{"type":"electronic","value":"1552-5279"}],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2025-01-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e091148"},{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T04:29:27Z","timestamp":1777782567602,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1045737"],"award-info":[{"award-number":["1045737"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Appl Gerontol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"Objective: To describe demographic features and well-being of carers of Aboriginal Australians aged \u226545 years in remote Western Australia. Method: Carer burden, empowerment, and depression were assessed in 124 Aboriginal carers in four remote Aboriginal communities. Results: Carers were aged 38.8 \u00b1 15.0 years, 73.4% were female, and 75.8% were children or grandchildren of the person cared for. The mean Zarit-6 score was 3.7 \u00b1 3.6. Attending high school (odds ratio [OR] = 0.3; 95% confidence interval [CI] = [0.1, 0.7]) and feeling empowered (OR = 0.2; 95% CI = [0.1, 0.8]) were inversely associated with carer burden; female carers were less likely to feel empowered (OR = 0.4; 95% CI = [0.2, 0.9]); and empowerment was inversely associated with depression (OR = 0.3; 95% CI = [0.1, 0.7]). Discussion: Aboriginal carers in remote communities are relatively young and most are children or grandchildren. Carer burden was lower than anticipated. However, existing tools may not adequately measure Aboriginal perspectives. Education and empowerment are key factors which support programs must consider.<\/jats:p>","DOI":"10.1177\/0733464819898667","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T07:39:51Z","timestamp":1578641991000},"page":"693-702","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The Well-Being of Carers of Older Aboriginal People Living in the Kimberley Region of Remote Western Australia: Empowerment, Depression, and Carer Burden"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0391-3898","authenticated-orcid":false,"given":"Dina","family":"LoGiudice","sequence":"first","affiliation":[{"name":"Melbourne Health, Victoria, Australia"},{"name":"The University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathryn M.","family":"Josif","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Australia"},{"name":"The University of Notre Dame Australia, Broome, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roslyn","family":"Malay","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zo\u00eb","family":"Hyde","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Haswell","sequence":"additional","affiliation":[{"name":"Queensland University of Technology, Kelvin Grove, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa A.","family":"Lindeman","sequence":"additional","affiliation":[{"name":"Flinders University, Alice Springs, Northern Territory, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5148-0188","authenticated-orcid":false,"given":"Christopher","family":"Etherton-Beer","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Atkinson","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Bessarab","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Flicker","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Smith","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"bibr1-0733464819898667","author":"Australian Bureau of Statistics","year":"2013","journal-title":"Estimates of Aboriginal and Torres Strait Islander Australians, 2011"},{"key":"bibr2-0733464819898667","author":"Australian Bureau of Statistics","year":"2015","journal-title":"Disability, ageing and carers, Australia"},{"key":"bibr3-0733464819898667","doi-asserted-by":"crossref","unstructured":"Almeida O. P., Flicker L., Fenner S., Smith K., Hyde Z., Atkinson D. LoGiudice D. (2014). The Kimberley assessment of depression of older Indigenous Australians: Prevalence of depressive disorders, risk factors and validation of the KICA-Dep Scale. PLOS ONE, 9(4), Article e94983. https:\/\/doi.org\/10.1371\/journal.pone.0094983","DOI":"10.1371\/journal.pone.0094983"},{"key":"bibr4-0733464819898667","doi-asserted-by":"crossref","unstructured":"Alpass F., Pond R., Stephens C., Stevenson B., Keeling S., Towers A. (2013). The influence of ethnicity and gender on caregiver health in older New Zealanders. Journals of Gerontology: Series B, Psychological Sciences and Social Sciences, 68(5), 783\u2013793. https:\/\/doi.org\/10.1093\/geronb\/gbt060","DOI":"10.1093\/geronb\/gbt060"},{"key":"bibr5-0733464819898667","doi-asserted-by":"crossref","unstructured":"Arkles R., Jankelson C., Radford K., Jackson Pulver L. (2018). 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The PTSD checklist (PCL): Reliability validity and diagnostic utility [Paper presentation]. 9th Annual Conference of the International Society for Traumatic Stress Studies San Antonio TX USA."},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2012.09.002"}],"container-title":["Journal of Mental Health"],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/09638237.2023.2182418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T15:36:59Z","timestamp":1696865819000},"score":7.5798984,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/09638237.2023.2182418"}},"issued":{"date-parts":[[2023,3,7]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9,3]]}},"alternative-id":["10.1080\/09638237.2023.2182418"],"URL":"https:\/\/doi.org\/10.1080\/09638237.2023.2182418","ISSN":["0963-8237","1360-0567"],"issn-type":[{"value":"0963-8237","type":"print"},{"value":"1360-0567","type":"electronic"}],"published":{"date-parts":[[2023,3,7]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ijmh20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ijmh20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:15:32Z","timestamp":1785906932410,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2025,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The Adelaide Score is an artificial intelligence system that integrates objective vital signs and laboratory tests to predict likelihood of hospital discharge.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective implementation trial was conducted at the Lyell McEwin Hospital in South Australia. The Adelaide Score was added to existing human, artificial intelligence, and other technological infrastructure for the first 28\u2009days of April 2024 (intervention), and outcomes were compared using parametric, non\u2010parametric and health economic analyses, to those in the first 28\u2009days of April 2023 (control). Artificial intelligence evaluated inpatients admitted under 18 surgical and medical teams, and patients of high likelihood of discharge were provided, on working shifts between Thursday to Sunday, to the Supportive Weekend Interprofessional Flow Team (SWIFT) comprising a senior nurse and pharmacist.<\/jats:p><\/jats:sec>Results<\/jats:title>Two thousand nine hundred and sixty\u2010eight admissions were included across intervention and control periods. Relative to the control group, use of the Adelaide Score in the intervention group resulted in significantly shorter median length of stay (3.1 versus 2.9\u2009days, P<\/jats:italic>\u2009=\u20090.028) and significantly lower seven\u2010day readmission rate (7.1 versus 5.0%, p\u2009=\u20090.02). The 0.2 bed\u2010day reduction in median length of stay produced a cost saving of $735\u2009708.60 across the 28\u2010day period, or $9\u2009564\u2009211.80 across a 52\u2010week\u2009year. There was no significant difference between intervention and control groups in median length of stay for patients discharged on weekends, in\u2010hospital mortality, or discharge to non\u2010home destinations.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The prospective implementation of the Adelaide Score was associated with improved hospital and cost efficiency, alongside lower readmissions, for patients across surgical and medical services.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.19383","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T02:25:32Z","timestamp":1735957532000},"page":"342-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Adelaide Score: prospective implementation of an artificial intelligence system to improve hospital and cost efficiency"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3880-3840","authenticated-orcid":false,"given":"Joshua G.","family":"Kovoor","sequence":"first","affiliation":[{"name":"Ballarat Base Hospital Ballarat Victoria Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-3489","authenticated-orcid":false,"given":"Brandon","family":"Stretton","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-0378","authenticated-orcid":false,"given":"Aashray K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal North Shore Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Beath","sequence":"additional","affiliation":[{"name":"Ballarat Base Hospital Ballarat Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5692-8241","authenticated-orcid":false,"given":"Mathew O.","family":"Jacob","sequence":"additional","affiliation":[{"name":"Ballarat Base Hospital Ballarat Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5910-5224","authenticated-orcid":false,"given":"John M.","family":"Kefalianos","sequence":"additional","affiliation":[{"name":"Ballarat Base Hospital Ballarat Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2143-3896","authenticated-orcid":false,"given":"Gavin J.","family":"Carmichael","sequence":"additional","affiliation":[{"name":"Ballarat Base Hospital Ballarat Victoria Australia"},{"name":"University of Melbourne Ballarat Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar","family":"Zaka","sequence":"additional","affiliation":[{"name":"Gold Coast University Hospital Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry","family":"O'Callaghan","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrirajh","family":"Satheakeerthy","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Booth","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6672-0852","authenticated-orcid":false,"given":"Thomson","family":"Delloso","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6690-342X","authenticated-orcid":false,"given":"Thomas J.","family":"Hugh","sequence":"additional","affiliation":[{"name":"Royal North Shore Hospital Adelaide South Australia Australia"},{"name":"University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weng Onn","family":"Chan","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"The Queen Elizabeth Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy J.","family":"Maddern","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"The Queen Elizabeth Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Balan\u2010Vnuk","sequence":"additional","affiliation":[{"name":"SA Government Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Cusack","sequence":"additional","affiliation":[{"name":"SA Government Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Gilbert","sequence":"additional","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Lyell McEwin Hospital 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Available from URL:https:\/\/www.adelaidenow.com.au\/subscribe\/news\/1\/?sourceCode=AAWEB_WRE170_a_GGL&dest=https%3A%2F%2Fwww.adelaidenow.com.au%2Fnews%2Fsouth\u2010australia%2Fadelaide\u2010score\u2010artificial\u2010intelligence\u2010to\u2010predict\u2010when\u2010patients\u2010can\u2010be\u2010discharged\u2010and\u2010break\u2010hospital\u2010bed\u2010gridlocks%2Fnews\u2010story%2Ff0603329e7c82bc251517214d0b861ed&memtype=anonymous&mode=premium&v21=GROUPA\u2010Segment\u20101\u2010NOSCORE."},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","unstructured":"ShoubridgeC MaddisonJ LynchJ BoydM.Profiling health and socioeconomic disadvantage in the northern Adelaide Local Health Network population. medRxiv;2024.","DOI":"10.1101\/2024.01.02.24300748"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-024-03689-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2023.08.021"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","unstructured":"KovoorJG StrettonB GuptaAK BacchiS.The Rosetta System: lessons for rural Australian healthcare from successful implementation of a hospital\u2010wide natural language processing system in metropolitan South Australia. 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Available from URL:https:\/\/www.aihw.gov.au\/reports-data\/myhospitals\/hospital\/h0541."},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.52225"},{"key":"e_1_2_9_22_1","unstructured":"Australian Medical Association.Public hospitals: cycle of crisis;2021."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14962"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.18263"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.14307"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16308"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.2310"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2021.09.033"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001272"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2015.1087"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.52081"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.15479"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.13648"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2024.009"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.14395"}],"container-title":["ANZ Journal of Surgery"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.19383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T07:24:48Z","timestamp":1755588288000},"score":7.5797443,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.19383"}},"issued":{"date-parts":[[2025,1,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/ans.19383"],"URL":"https:\/\/doi.org\/10.1111\/ans.19383","archive":["Portico"],"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"published":{"date-parts":[[2025,1,3]]},"assertion":[{"value":"2024-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:38:04Z","timestamp":1753889884075,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,6,20]]},"abstract":"Background: There are a few prediction models for chronic complications in people with type 2 diabetes (T2D). This study developed such risk models.<\/jats:p>\n Methods: Data from 9795 adults with T2D in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial were used to develop risk prediction models for total CVD events, cardiovascular mortality, amputations and new microvascular events using 27 candidate traditional risk factors and additional novel biomarkers (incl. vascular and systemic inflammation, oxidative stress; n=26) using exhaustive search methods.<\/jats:p>\n Results: There were 1295 total first CVD events, 267 CVD deaths, 115 amputations and 1530 new microvascular events. A total of 19 and 18 traditional risk factors were selected in the clinical risk models for total CVD events and CVD mortality, with AUC of 0.723 and 0.821 respectively. For individual microvascular complications, the AUC of their models ranged from 0.656 to 0.895. The addition of novel biomarkers to the clinical risk models only resulted in modestly higher AUC (Table below).<\/jats:p>\n Conclusion: New clinical risk models can be implemented as risk prediction tools for chronic complications in adults with T2D, including for sight-threatening retinopathy and amputations. Novel biomarkers may guide future research on disease mechanisms, but had limited predictive value over clinical variables.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n K.Ong: None. M.Taskinen: Board Member; Novo Nordisk, Consultant; Eli Lilly and Company, Novartis, Akcea, Research Support; Novo Nordisk. R.J.Simes: None. A.Jenkins: Advisory Panel; Insulet Corporation, Board Member; Insulin for Life, Research Support; Abbott Diabetes, Medtronic, Hemsley Charitable Trust, Juvenile Diabetes Research Foundation (JDRF), National Institutes of Health. A.C.Keech: None. On behalf of the field study investigators: n\/a. R.L.O'connell: None. A.S.Januszewski: None. M.W.Donoghoe: None. V.Gebski: None. D.Sullivan: None. K.Rye: None. R.S.Scott: None. J.D.Best: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Laboratories Fournier; National Health and Medical Research Council of Australia (457103, 1024105, 1037786)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db23-1350-p","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:10:35Z","timestamp":1687237835000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1350-P: Risk Models for the Development of Cardiovascular and Microvascular Events in Adults with Type 2 Diabetes in the FIELD Study"],"prefix":"10.2337","volume":"72","author":[{"given":"KWOK","family":"LEUNG ONG","sequence":"first","affiliation":[{"name":"Sydney, Australia, Kensington, Australia, Camperdown, Australia, Christchurch, New Zealand, Singapore, Singapore, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RACHEL L.","family":"O'CONNELL","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Kensington, Australia, Camperdown, Australia, Christchurch, New Zealand, Singapore, Singapore, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDRZEJ S.","family":"JANUSZEWSKI","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Kensington, Australia, Camperdown, Australia, Christchurch, New Zealand, Singapore, Singapore, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK W.","family":"DONOGHOE","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Kensington, Australia, Camperdown, Australia, Christchurch, New Zealand, Singapore, Singapore, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VAL","family":"GEBSKI","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Kensington, Australia, Camperdown, Australia, Christchurch, New Zealand, Singapore, Singapore, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"SULLIVAN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Kensington, Australia, Camperdown, Australia, Christchurch, New Zealand, Singapore, Singapore, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KERRY","family":"ANN RYE","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Kensington, Australia, Camperdown, Australia, Christchurch, New Zealand, Singapore, Singapore, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RUSSELL S.","family":"SCOTT","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Kensington, Australia, Camperdown, Australia, Christchurch, New Zealand, Singapore, Singapore, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAMES D.","family":"BEST","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Kensington, Australia, Camperdown, Australia, Christchurch, New Zealand, Singapore, Singapore, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARJA-RIITTA","family":"TASKINEN","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Kensington, Australia, Camperdown, Australia, Christchurch, New Zealand, Singapore, Singapore, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERT J.","family":"SIMES","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Kensington, Australia, Camperdown, Australia, Christchurch, New Zealand, Singapore, Singapore, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Kensington, Australia, Camperdown, Australia, Christchurch, New Zealand, Singapore, Singapore, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTHONY C.","family":"KEECH","sequence":"additional","affiliation":[{"name":"Sydney, Australia, Kensington, Australia, Camperdown, Australia, Christchurch, New Zealand, Singapore, Singapore, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1350-P\/149173\/1350-P-Risk-Models-for-the-Development-of","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1350-P\/149173\/1350-P-Risk-Models-for-the-Development-of","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T05:10:35Z","timestamp":1687237835000},"score":7.5796595,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/72\/Supplement_1\/1350-P\/149173\/1350-P-Risk-Models-for-the-Development-of"}},"issued":{"date-parts":[[2023,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db23-1350-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2023,6,20]]},"article-number":"1350-P"},{"indexed":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T05:46:49Z","timestamp":1741153609279,"version":"3.38.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1_Supplement","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2019,5,1]]},"abstract":"Abstract<\/jats:title>\n Na\u00efve CD4+CD25+Foxp3+T regulatory cells (tTreg) activated by specific alloantigen (Ag) and IL-4 express IL-5Ralpha. We examined if IL-5 treatment activated alloAg specific Treg to prevent chronic rejection in F344 rats grafted with Lewis hearts. 5000units rIL-5 (rIL-5Rx) was given daily from 7d after grafting when rejection had started. Changes in CD4+CD25+T cells were assessed by FACS, RT-PCR of Il5ra and response to alloAg in MLC.<\/jats:p>\n Sham Rx rats fully rejected their grafts by 28d while IL-5Rx for 10d reversed rejection and grafts survived 60d (p&lt;0.01). There were rejection episodes after stopping IL-5 but continued IL-5Rx reduced this. Pre-treatment with anti-CD25 or anti-IL-4 mAb abolished the benefit of rIL-5Rx, all grafts rejected by 28d. IL-5 treated hosts had increased CD4+CD25+T cells, 6\u20138% vs 3\u20134% in controls. After 10d of rIL-5Rx, host CD4+CD25+T cells responded to Lewis but not to F344 or third-party PVG alloAg in MLC, showing activation of alloAg-specific Treg. CD4+CD25+T cells from rats treated for 50d with rIL-5 had more il5ra, remained FOXP3+ and in MLC rIL-5 enhanced responses to Lewis but not other alloAg. These findings are consistent with IL-4 and alloAg activating tTreg to induce Ag-specific Treg that suppress rejection.<\/jats:p>\n To demonstrate rIL-4 and specific alloantigen activated na\u00efve tTreg to suppress rejection, these cells were prepared ex vivo. 5\u00d7106 of these IL-4 alloAg activated tTreg, given after rejection commenced, reversed rejection. 5\u00d7106 fresh na\u00efve tTreg or 5\u00d7106 tTreg activated by third-party PVG alloAg had no effect on rejection.<\/jats:p>\n IL-5 prevented heart graft rejection through hosts\u2019 CD25+Treg that had been activated by alloAg and IL-4. IL-5 therapy may have potential to prevent chronic allograft rejection.<\/jats:p>","DOI":"10.4049\/jimmunol.202.supp.186.11","type":"journal-article","created":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T12:13:36Z","timestamp":1672575216000},"page":"186.11-186.11","source":"Crossref","is-referenced-by-count":0,"title":["Th2 cytokines and specific donor alloantigen activated CD4+CD25+T cells reverse chronic rejection: role of IL-4 and IL-5 in promoting antigen-specific Treg"],"prefix":"10.1093","volume":"202","author":[{"given":"Bruce Milne","family":"Hall","sequence":"first","affiliation":[{"name":"UNSW Australia ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prateek","family":"Rakesh","sequence":"additional","affiliation":[{"name":"UNSW Australia ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giang","family":"Tran","sequence":"additional","affiliation":[{"name":"UNSW Australia ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Hall","sequence":"additional","affiliation":[{"name":"UNSW Australia ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukandeep","family":"Bedi","sequence":"additional","affiliation":[{"name":"UNSW Australia ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine Margaret","family":"Robinson","sequence":"additional","affiliation":[{"name":"UNSW Australia ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Sharland","sequence":"additional","affiliation":[{"name":"Sydney University ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaunmin","family":"Wang","sequence":"additional","affiliation":[{"name":"Sydney University ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne Jean","family":"Hodgkinson","sequence":"additional","affiliation":[{"name":"UNSW Australia ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirupama Darshan","family":"Verma","sequence":"additional","affiliation":[{"name":"UNSW Australia ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,1]]},"container-title":["The Journal of Immunology"],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/202\/1_Supplement\/186.11\/7957879","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/202\/1_Supplement\/186.11\/7957879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T20:18:17Z","timestamp":1741119497000},"score":7.579568,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/202\/1_Supplement\/186.11\/7957879"}},"issued":{"date-parts":[[2019,5,1]]},"references-count":0,"journal-issue":{"issue":"1_Supplement","published-print":{"date-parts":[[2019,5,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.202.supp.186.11","ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"published-other":{"date-parts":[[2019,5]]},"published":{"date-parts":[[2019,5,1]]}},{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:13:44Z","timestamp":1780935224949,"version":"3.54.1"},"reference-count":31,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2026,3,3]]},"abstract":"\n Aim<\/jats:title>\n Surgical aortic valve replacement (SAVR) improves survival in severe, symptomatic aortic stenosis (AS), but whether it fully restores life expectancy is uncertain. This study aimed to evaluate long-term relative survival following SAVR compared with the general population and identify predictors of any residual survival discrepancies.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n A total of 1287 patients (median age 71 (63\u201377) years, 32% female) undergoing SAVR for \u2265moderate\u2009AS were identified from the Western Australian Heart Valves Study database. Flexible parametric models were used to estimate relative survival.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Over a median follow-up of 47 (23\u201381) months, 247 (19%) patients died. All\u2010cause 30\u2010day, 1\u2010year, 5\u2010year and 10-year relative survivals were 97.3%, 97.2%, 93.0% and 83.3%, respectively, compared with an age-matched, sex-matched and year-matched general population. Flexible multivariable modelling indicated impaired left ventricular ejection fraction (LVEF) (45%\u201360%, excess HR 1.97, 95%\u2009CI 1.11 to 3.51, p=0.02; 30%\u201345%, excess HR 2.40, 95%\u2009CI 1.24 to 4.64, p=0.01; <30%, excess HR 2.96, 95%\u2009CI 1.18 to 7.39, p=0.02), significant mitral regurgitation (MR) (excess HR 2.28, 95%\u2009CI 1.29 to 4.03, p=0.005), Indigenous status (excess HR 4.53, 95%\u2009CI 2.03 to 10.12, p<0.001), diabetes mellitus (excess HR 2.30, 95%\u2009CI 1.44 to 3.68, p<0.001), estimated glomerular filtration rate (eGFR) 30\u201359 mL\/kg\/1.73 m\n 2<\/jats:sup>\n (excess HR 2.74, 95% CI 1.33 to 5.65, p=0.006) and eGFR 0\u201329 mL\/kg\/1.73 m\n 2<\/jats:sup>\n (excess HR 5.75, 95% CI 2.36 to 13.99, p<0.001) were independently associated with long-term excess mortality relative to that of the national comparator, whereas age, sex, year of surgery, concomitant coronary artery bypass graft surgery and symptom status were not.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In a contemporary population, relative survival following SAVR for significant AS was reduced compared with an age-matched, sex-matched and year-matched general population. Impaired LVEF, significant MR, Indigenous status, renal impairment and diabetes mellitus were independent predictors of long-term excess mortality. Timely intervention and optimised postoperative follow-up may be crucial for the restoration of normal life expectancy following SAVR.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/heartjnl-2025-327029","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:40:21Z","timestamp":1773873621000},"page":"heartjnl-2025-327029","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Life expectancy and determinants of relative survival following surgical aortic valve replacement for aortic stenosis"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8258-8802","authenticated-orcid":false,"given":"Steele C","family":"Butcher","sequence":"first","affiliation":[{"name":"Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Lewin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charley A","family":"Budgeon","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Cardiovascular Epidemiology Research Centre, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarryd","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A","family":"Courtney","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4761-980X","authenticated-orcid":false,"given":"Primero","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgie","family":"Graham","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M","family":"Sanfilippo","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Cardiovascular Epidemiology Research Centre, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke J","family":"Waller","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Ihdayhid","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia"},{"name":"Medical School, Curtin University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-3963","authenticated-orcid":false,"given":"Tom","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Passage","sequence":"additional","affiliation":[{"name":"The University of Notre Dame Australia School of Medicine - Fremantle Campus, Fremantle, Western Australia, Australia"},{"name":"Department of Cardiothoracic Surgery, Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J James","family":"Edelman","sequence":"additional","affiliation":[{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Department of Cardiothoracic Surgery, Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M","family":"Rankin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Briffa","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Cardiovascular Epidemiology Research Centre, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2417-4673","authenticated-orcid":false,"given":"Graham S","family":"Hillis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"2026031815401803000_heartjnl-2025-327029v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00570-z"},{"key":"2026031815401803000_heartjnl-2025-327029v1.2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000923"},{"key":"2026031815401803000_heartjnl-2025-327029v1.3","doi-asserted-by":"crossref","unstructured":"Beyersdorf F , Vahanian A , Milojevic M , et al . Corrigendum to: 2021 ESC\/EACTS Guidelines for the management of valvular heart disease. Eur Heart J 2022;62. doi:10.1093\/ejcts\/ezac209","DOI":"10.1093\/ejcts\/ezac209"},{"key":"2026031815401803000_heartjnl-2025-327029v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.06.050"},{"key":"2026031815401803000_heartjnl-2025-327029v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.053"},{"key":"2026031815401803000_heartjnl-2025-327029v1.6","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.jacc.2021.09.861","article-title":"Life Expectancy After Surgical Aortic Valve Replacement","volume":"78","author":"Martinsson","year":"2021","journal-title":"J Am Coll 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survival of patients after heart valve replacement","volume":"11","author":"Abdelnoor","year":"1990","journal-title":"Eur Heart J"},{"key":"2026031815401803000_heartjnl-2025-327029v1.23","doi-asserted-by":"crossref","first-page":"5582","DOI":"10.21037\/jtd-20-2213","article-title":"Operative mortality in adult cardiac surgery: is the currently utilized definition justified?","volume":"13","author":"Chan","year":"2021","journal-title":"J Thorac Dis"},{"key":"2026031815401803000_heartjnl-2025-327029v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.08.040"},{"key":"2026031815401803000_heartjnl-2025-327029v1.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.03.064"},{"key":"2026031815401803000_heartjnl-2025-327029v1.26","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1001\/jamacardio.2018.3152","article-title":"Outcomes of Patients With Asymptomatic Aortic Stenosis Followed Up in Heart Valve Clinics","volume":"3","author":"Lancellotti","year":"2018","journal-title":"JAMA Cardiol"},{"key":"2026031815401803000_heartjnl-2025-327029v1.27","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.acvd.2019.04.003","article-title":"Pathophysiology and management of combined aortic and mitral regurgitation","volume":"112","author":"Unger","year":"2019","journal-title":"Arch Cardiovasc Dis"},{"key":"2026031815401803000_heartjnl-2025-327029v1.28","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv680"},{"key":"2026031815401803000_heartjnl-2025-327029v1.29","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50851"},{"key":"2026031815401803000_heartjnl-2025-327029v1.30","doi-asserted-by":"crossref","first-page":"S247","DOI":"10.1016\/j.hlc.2025.06.246","article-title":"Life Expectancy and Determinants of Relative Survival Following Surgical Aortic Valve Replacement for Aortic Stenosis","volume":"34","author":"Butcher","year":"2025","journal-title":"Heart Lung Circ"},{"key":"2026031815401803000_heartjnl-2025-327029v1.31","doi-asserted-by":"crossref","unstructured":"Butcher SC , Lewin S , Budgeon CA , et al . Life expectancy and determinants of relative survival following surgical aortic valve replacement for aortic stenosis. Eur Heart J 2025;46. doi:10.1093\/eurheartj\/ehaf784.2495","DOI":"10.1093\/eurheartj\/ehaf784.2495"}],"container-title":["Heart"],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heartjnl-2025-327029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:40:24Z","timestamp":1773873624000},"score":7.5795193,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heartjnl-2025-327029"}},"issued":{"date-parts":[[2026,3,18]]},"references-count":31,"alternative-id":["10.1136\/heartjnl-2025-327029"],"URL":"https:\/\/doi.org\/10.1136\/heartjnl-2025-327029","ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"published":{"date-parts":[[2026,3,18]]}},{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:42:33Z","timestamp":1776184953310,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australas J Ultrason Med"],"published-print":{"date-parts":[[2020,2]]},"abstract":"Abstract<\/jats:title>Ultrasound is the first\u2010line imaging modality in the assessment of the female reproductive system in all age groups. However, the paediatric and adolescent subset of patients present a particular set of challenges. These include technical challenges that come from largely being limited by transabdominal imaging as well as dealing with the often\u2010complex social issues around the sexual health of adolescents. In addition, this group of patients has a unique set of pathologies that are not seen in the adult population and conversely, common gynaecological conditions affecting adults such as endometriosis and polycystic ovarian syndrome are difficult to diagnose in adolescents. Therefore, we propose that paediatric and adolescent gynaecological ultrasound requires a different approach. This paper summarises the differences in technique, common pathologies and touches on some of the relevant social issues that are unique to this population of patients.<\/jats:p>","DOI":"10.1002\/ajum.12200","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T12:56:38Z","timestamp":1582203398000},"page":"10-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["How to perform a gynaecological ultrasound in the paediatric or adolescent patient"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7094-3950","authenticated-orcid":false,"given":"Alison","family":"Deslandes","sequence":"first","affiliation":[{"name":"Specialist Imaging Partners Adelaide South Australia Australia"},{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catrina","family":"Pannucio","sequence":"additional","affiliation":[{"name":"Specialist Imaging Partners Adelaide South Australia Australia"},{"name":"Women\u2019s and Children\u2019s Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreya","family":"Parasivam","sequence":"additional","affiliation":[{"name":"Specialist Imaging Partners Adelaide South Australia Australia"},{"name":"Women\u2019s and Children\u2019s Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Balogh","sequence":"additional","affiliation":[{"name":"Specialist Imaging Partners Adelaide South Australia Australia"},{"name":"Women\u2019s and Children\u2019s Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asha","family":"Short","sequence":"additional","affiliation":[{"name":"Women\u2019s and Children\u2019s Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.21.6.g01nv041393"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157375"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071465"},{"issue":"9","key":"e_1_2_10_5_1","first-page":"590","article-title":"Disorders of puberty: an approach to diagnosis and management","volume":"96","author":"Klein DA","year":"2017","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00287.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2004.00338.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2017.06.008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.011312"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00503-1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2005.01.003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-007-0429-x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2004.23.12.1643"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200611000-00059"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a019588"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-13"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2007.09.006"},{"key":"e_1_2_10_18_1","unstructured":"Australia E.2018. Available from:https:\/\/www.endometriosisaustralia.org\/research"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-3188(03)00066-4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2003.09.008"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15955"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2011.07.005"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2019.05.005"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey256"}],"container-title":["Australasian Journal of Ultrasound in Medicine"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajum.12200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajum.12200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajum.12200","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajum.12200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T04:35:23Z","timestamp":1694061323000},"score":7.579519,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajum.12200"}},"issued":{"date-parts":[[2020,2]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/ajum.12200"],"URL":"https:\/\/doi.org\/10.1002\/ajum.12200","archive":["Portico"],"ISSN":["1836-6864","2205-0140"],"issn-type":[{"value":"1836-6864","type":"print"},{"value":"2205-0140","type":"electronic"}],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"2019-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:46:31Z","timestamp":1753879591581,"version":"3.41.2"},"reference-count":0,"publisher":"American Society of Mechanical Engineers","license":[{"start":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T00:00:00Z","timestamp":1654387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.asme.org\/publications-submissions\/publishing-information\/legal-policies"}],"content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2022,6,5]]},"abstract":"Abstract<\/jats:title>\n Accurate and reliable phase-resolved prediction of ocean surface waves is crucial for many offshore operations in ocean engineering and marine science. One important application is in optimal control of a power take-off in a wave energy converter, leading to significantly higher power production. Our interest is the forecasting of wave fields based on measurements obtained from multiple upwave locations in moderate seas with small directional spreading angles, such as is prevalent along the south coast of Australia. The prediction model, based on FFTs and propagation of waves according to the linear dispersion relation, is applied to both wave groups and irregular wave fields generated in a wave basin and, additionally, to ocean waves measured with drifting wave buoys. To account for spreading, the model numerically advances linear, plane (i.e. long-crested) waves in space at an optimum offset angle equal to the underlying sea-state root-mean-square spreading angle. Averaging predictions based on a few slightly separated measurement locations, each weighted according to the estimated variance of the individual prediction, is shown to be more accurate than that from any single location. We also assess in detail the effect of drifting-buoy measurements in both long-crested and short-crested seas using synthetic wave records and show that it is possible to satisfactorily reconstruct the signal at fixed points based on the Doppler shift felt by the drifting buoy. The reconstructed signals give much better predictions compared to those completely neglecting the effect of even rather slow drift.<\/jats:p>","DOI":"10.1115\/omae2022-80885","type":"proceedings-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T16:33:01Z","timestamp":1666801981000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":0,"title":["Wave-by-Wave Prediction in Narrowly Spread Seas Using Fixed- and Drifting-Point Wave Records: Validation Using Physical Measurements"],"prefix":"10.1115","author":[{"given":"Thobani","family":"Hlophe","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Wolgamot","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul H.","family":"Taylor","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi","family":"Kurniawan","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Orszaghova","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Draper","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33","published-online":{"date-parts":[[2022,10,13]]},"event":{"name":"ASME 2022 41st International Conference on Ocean, Offshore and Arctic Engineering","start":{"date-parts":[[2022,6,5]]},"sponsor":["Ocean, Offshore and Arctic Engineering Division"],"location":"Hamburg, Germany","end":{"date-parts":[[2022,6,10]]},"acronym":"OMAE2022"},"container-title":["Volume 8: Ocean Renewable Energy"],"link":[{"URL":"https:\/\/asmedigitalcollection.asme.org\/OMAE\/proceedings-pdf\/doi\/10.1115\/OMAE2022-80885\/6929719\/v008t09a075-omae2022-80885.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/asmedigitalcollection.asme.org\/OMAE\/proceedings-pdf\/doi\/10.1115\/OMAE2022-80885\/6929719\/v008t09a075-omae2022-80885.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T16:33:01Z","timestamp":1666801981000},"score":7.579507,"resource":{"primary":{"URL":"https:\/\/asmedigitalcollection.asme.org\/OMAE\/proceedings\/OMAE2022\/85932\/V008T09A075\/1148064"}},"issued":{"date-parts":[[2022,6,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1115\/omae2022-80885","published":{"date-parts":[[2022,6,5]]},"article-number":"V008T09A075"},{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T04:11:53Z","timestamp":1747368713040,"version":"3.40.5"},"reference-count":0,"publisher":"Clinical Exercise Physiology Association","issue":"s2","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2024,5]]},"abstract":"\n INTRODUCTION<\/jats:title>\n Initial treatment recommendations for symptomatic femoroacetabular impingement syndrome include non-surgical therapies such as injections and rehabilitation. However, many patients undergo isolated injections or a rudimentary exercise regime. This study investigated the benefit of a combined intra-articular hip injection and structured exercise rehabilitation program in patients with FAIS.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Participants were recruited and underwent a guided intra-articular injection of corticosteroid and local anaesthetic, followed by a 12-week rehabilitation program. Patients were assessed pre-and post-injection(8 weeks, 4, 6, 12 and 24 months) via patient-reported outcome measures including the 33-item International Hip Outcome Tool and Hip Outcome score. Hip ROM and peak isometric hip strength in all planes were assessed, along with single-limb hop capacity. Limb Symmetry Indices were calculated. The percentage of patients transitioning toward surgery over the period was evaluated.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n A total of 44 patients underwent the injection and completed the initial 8-week rehabilitation component. A significant improvement (p<0.05) in all PROMs was observed, with 93% of patients satisfied. A significant increase (p<0.05) in all active hip ROM and isometric strength measures was observed, sustained over the 24-month period. Bilateral improvements in hop capacity were observed, with all hop test LSIs significantly improving (p<0.05). Overall, 14 patients (32%) progressed toward surgical intervention over the 24-month post-injection period. These patients reported significantly worse (p<0.05) PROMs pre-surgery and more pain within the first 4 weeks post-injection.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n This is the first study seeking to implement and comprehensively assess a best-practice, multimodal non-operative program consisting of an intra-articular injection and a structured exercise program. Most patients with symptomatic FAIS demonstrated significant improvement in symptoms.<\/jats:p>\n <\/jats:sec>","DOI":"10.31189\/2165-7629-13-s2.321","type":"journal-article","created":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T14:35:50Z","timestamp":1714919750000},"page":"321","source":"Crossref","is-referenced-by-count":0,"title":["PATIENTS WITH FEMOROACETABULAR IMPINGEMENT SYNDROME OBTAIN SIGNIFICANT AND SUSTAINED IMPROVEMENT FOLLOWING A COMBINED HIP INJECTION AND REHABILITATION PROGRAM"],"prefix":"10.31189","volume":"13","author":[{"given":"Ms Jen","family":"Woodhouse","sequence":"first","affiliation":[{"name":"HFRC, Nedlands, WA, Australia"},{"name":"Murdoch University, Murdoch, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dr Jay","family":"Ebert","sequence":"additional","affiliation":[{"name":"HFRC, Nedlands, WA, Australia"},{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dr Peter","family":"Edwards","sequence":"additional","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"},{"name":"Orthopaedic Research Foundation of Western Australia, Claremont, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mr Randeep","family":"Aujla","sequence":"additional","affiliation":[{"name":"University Hospitals of Leicester, Leicester, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mr Peter","family":"D\u2019Alessandro","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Foundation of Western Australia, Claremont, Western Australia, Australia"},{"name":"Coastal Orthopaedics, Claremont, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16145","container-title":["Journal of Clinical Exercise Physiology"],"link":[{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/13\/s2\/article-p321-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/jcep\/article-pdf\/13\/s2\/321\/3369458\/i2165-7629-13-s2-321.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/13\/s2\/article-p321-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/13\/s2\/article-p321-s.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:39:58Z","timestamp":1747355998000},"score":7.579468,"resource":{"primary":{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/13\/s2\/article-p321-s.xml"}},"issued":{"date-parts":[[2024,5]]},"references-count":0,"journal-issue":{"issue":"s2"},"URL":"https:\/\/doi.org\/10.31189\/2165-7629-13-s2.321","ISSN":["2165-7629","2165-6193"],"issn-type":[{"type":"electronic","value":"2165-7629"},{"type":"print","value":"2165-6193"}],"published":{"date-parts":[[2024,5]]}},{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:51:15Z","timestamp":1768978275510,"version":"3.49.0"},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"2_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2026,1,20]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Prostate cancer (PC) is the second leading cause of cancer-related death in men, with metastatic castration-resistant PC (mCRPC) remaining largely incurable. Prostate-specific membrane antigen (PSMA) is a validated target, with PSMA-directed radioligand therapy demonstrating survival benefit in mCRPC. Targeted alpha therapies (TAT) with isotopes Lead-212 (212Pb) and Actinium-225 (225Ac) are in clinical development and deliver high-linear-energy-transfer radiation, inducing potent cytotoxicity and potentially enhancing anti-tumour immunity. Current PSMA-positive preclinical models rely on xenografts or engineered murine cells, limiting evaluation of TAT-induced immune modulation thus far.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n To investigate the immune-modulatory effects of 212Pb-TAT in metastatic PC, we sought to establish (i) a syngeneic murine model of metastatic PC expressing murine PSMA (mPSMA), and (ii) a PSMA-directed TAT tool compound with high affinity for mPSMA.<\/jats:p>\n <\/jats:sec>\n \n Methodology:<\/jats:title>\n Murine metastatic PC cells (RM1-BM), which recapitulate late-stage TP53-mutant disease, were engineered to express murine FOLH1 (mPSMA) using a PiggyBac transposon system. Expression of mPSMA was confirmed both in vitro and in vivo by western blotting and immunohistochemistry. The TAT agent 212Pb-PS0001 (AdvanCell) was assessed in biodistribution and efficacy studies in immunocompetent C57Bl\/6 mice.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n RM1-BM-mFolh1 cells expressed mPSMA comparably to human PSMA-positive C4-2 cells. 212Pb-PS0001 showed selective tumour uptake in RM1-BM-mFolh1 models, with minimal off-target accumulation. Therapeutic evaluation demonstrated that a single dose of 212Pb-PS0001 significantly suppressed RM1-BM-mFolh1 tumour growth in immunocompetent mice, while untreated controls exhibited progressive disease. Notably, several animals achieved durable tumour control, suggesting potential activation of an anti-tumour immune response.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n We established a syngeneic mPSMA-positive metastatic PC model suitable for studying the immune-modulatory effects of PSMA-targeted therapies. This model represents a robust platform for assessing therapeutic efficacy, elucidating immune mechanisms of action, and evaluating rational combination strategies, including integration with immune checkpoint blockade. Preliminary studies with 212Pb-PS0001 demonstrated selective PSMA targeting, rapid clearance, and potent anti-tumour activity, supporting its use as PSMA-TAT tool compound.<\/jats:p>\n <\/jats:sec>\n \n Citation Format:<\/jats:title>\n Melissa Monterosso, Aneesha Jones, Kayden Kwah, Anna Amiss, Abby Sydes, Didier Boucher, Aimee Horsfall, Heather Green, Johannes Koehbach, Ralph Huebner, Yaowu He, Stephen Rose, Gary Li, Feifei Liu, Simon Puttick, Anna Karmann, John Hooper, Thomas Kryza. Development of an immunocompetent murine model of PSMA-positive metastatic prostate cancer to study the impact of PSMA-targeted therapies on the immune response [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Innovations in Prostate Cancer Research and Treatment; 2026 Jan 20-22; Philadelphia PA. Philadelphia (PA): AACR; Cancer Res 2026;86(2_Suppl):Abstract nr B040.<\/jats:p>\n <\/jats:sec>","DOI":"10.1158\/1538-7445.prostateca26-b040","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T18:07:56Z","timestamp":1768932476000},"page":"B040-B040","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract B040: Development of an immunocompetent murine model of PSMA-positive metastatic prostate cancer to study the impact of PSMA-targeted therapies on the immune response"],"prefix":"10.1158","volume":"86","author":[{"given":"Melissa","family":"Monterosso","sequence":"first","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneesha","family":"Jones","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayden","family":"Kwah","sequence":"additional","affiliation":[{"name":"2Mater Research Institute, Brisbane, Queensland, Australia, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Amiss","sequence":"additional","affiliation":[{"name":"3Advancell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abby","family":"Sydes","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Boucher","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimee","family":"Horsfall","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Green","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Koehbach","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Huebner","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaowu","family":"He","sequence":"additional","affiliation":[{"name":"2Mater Research Institute, Brisbane, Queensland, Australia, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Rose","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Li","sequence":"additional","affiliation":[{"name":"4AdvanCell, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Liu","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Puttick","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Karmann","sequence":"additional","affiliation":[{"name":"4AdvanCell, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Hooper","sequence":"additional","affiliation":[{"name":"2Mater Research Institute, Brisbane, Queensland, Australia, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kryza","sequence":"additional","affiliation":[{"name":"1AdvanCell, Brisbane, Australia,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/86\/2_Supplement\/B040\/771507\/Abstract-B040-Development-of-an-immunocompetent","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/86\/2_Supplement\/B040\/771507\/Abstract-B040-Development-of-an-immunocompetent","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T18:07:56Z","timestamp":1768932476000},"score":7.579454,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/86\/2_Supplement\/B040\/771507\/Abstract-B040-Development-of-an-immunocompetent"}},"issued":{"date-parts":[[2026,1,20]]},"references-count":0,"journal-issue":{"issue":"2_Supplement","published-print":{"date-parts":[[2026,1,20]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.prostateca26-b040","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2026,1,20]]}},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:40:53Z","timestamp":1651203653625},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.juro.2012.02.2221","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T03:48:17Z","timestamp":1333511297000},"source":"Crossref","is-referenced-by-count":0,"title":["2056 LOCATION AND PATHOLOGICAL CHARACTERISTICS OF CANCERS IN RADICAL PROSTATECTOMY SPECIMENS IDENTIFIED BY TRANS-PERINEAL BIOPSY COMPARED TO TRANS-RECTAL BIOPSY"],"prefix":"10.1097","volume":"187","author":[{"given":"Tania","family":"Hossack","sequence":"first","affiliation":[{"name":"Sydney, 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534712025839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534712025839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2012.02.2221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:13:06Z","timestamp":1651201986000},"score":7.5794344,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2012.02.2221"}},"issued":{"date-parts":[[2012,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1016\/j.juro.2012.02.2221"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2012.02.2221","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2012,4]]}},{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T06:03:20Z","timestamp":1766901800371,"version":"3.48.0"},"reference-count":5,"publisher":"CSIRO Publishing","issue":"2","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":5166,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2011,6,30]]},"abstract":"The frontier deepwater Otway and Sorell basins lie offshore of southwestern Victoria and western Tasmania at the eastern end of Australia\u2019s Southern Rift System. The basins developed during rifting and continental separation between Australia and Antarctica from the Cretaceous to Cenozoic. The complex structural and depositional history of the basins reflects their location in the transition from an orthogonal\u2013obliquely rifted continental margin (western\u2013central Otway Basin) to a transform continental margin (southern Sorell Basin).<\/jats:p>\n Despite good 2D seismic data coverage, these basins remain relatively untested and their prospectivity poorly understood. The deepwater (&gt; 500\u00a0m) section of the Otway Basin has been tested by two wells, of which Somerset\u20131 recorded minor gas shows. Three wells have been drilled in the Sorell Basin, where minor oil shows were recorded near the base of Cape Sorell\u20131.<\/jats:p>\n As part of the federal government-funded Offshore Energy Security Program, Geoscience Australia has acquired new aeromagnetic data and used open file seismic datasets to carry out an integrated regional study of the deepwater Otway and Sorell basins. Structural interpretation of the new aeromagnetic data and potential field modelling provide new insights into the basement architecture and tectonic history, and highlights the role of pre-existing structural fabric in controlling the evolution of the basins. Regional scale mapping of key sequence stratigraphic surfaces across the basins, integration of the regional structural analysis, and petroleum systems modelling have resulted in a clearer understanding of the tectonostratigraphic evolution and petroleum prospectivity of this complex basin system.<\/jats:p>","DOI":"10.1071\/aj10072","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T21:56:02Z","timestamp":1503352562000},"page":"692-692","source":"Crossref","is-referenced-by-count":5,"title":["Geology and petroleum prospectivity of the deepwater Otway and Sorell basins: new insights from an integrated regional study*"],"prefix":"10.1071","volume":"51","author":[{"given":"A.","family":"Stacey","sequence":"first","affiliation":[{"name":"AGeoscience Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"AGeoscience Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Nayak","sequence":"additional","affiliation":[{"name":"AGeoscience Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Struckmeyer","sequence":"additional","affiliation":[{"name":"AGeoscience Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Morse","sequence":"additional","affiliation":[{"name":"AGeoscience Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Totterdell","sequence":"additional","affiliation":[{"name":"AGeoscience Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Gibson","sequence":"additional","affiliation":[{"name":"AGeoscience Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2011,6,30]]},"reference":[{"issue":"3","key":"2025122723511350900_R1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.gr.2010.11.020","article-title":"Arc-continent collision and orogenesis in western Tasmanides: Insights from reactivated basement structures and formation of an ocean-continent transform boundary off western Tasmania.","volume":"19","author":"Gibson","year":"2011","journal-title":"Gondwana Research"},{"key":"2025122723511350900_R2"},{"key":"2025122723511350900_R3"},{"key":"2025122723511350900_R4"},{"key":"2025122723511350900_R5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1071\/AJ08009","article-title":"Understanding the critical success factors determining prospectivity, Otway Basin, Victoria.","volume":"49","author":"O\u2019Brien","year":"2009","journal-title":"APPEA Journal"}],"container-title":["The APPEA Journal"],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/51\/2\/692\/955168\/aj10072.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/51\/2\/692\/955168\/aj10072.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T04:51:17Z","timestamp":1766897477000},"score":7.5794344,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/ep\/article\/51\/2\/692\/119588\/Geology-and-petroleum-prospectivity-of-the"}},"issued":{"date-parts":[[2011,6,30]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,6,30]]}},"URL":"https:\/\/doi.org\/10.1071\/aj10072","ISSN":["1326-4966","2206-8996"],"issn-type":[{"type":"print","value":"1326-4966"},{"type":"electronic","value":"2206-8996"}],"published":{"date-parts":[[2011,6,30]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:41:01Z","timestamp":1753890061686,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: Emerging evidence suggests that gut microbiota influences gestational diabetes mellitus (GDM) development. Dietary interventions to modulate gut microbiota may help prevent GDM. The Healthy Gut Diet for preventing GDM Study aimed to achieve this in pregnant women with one or more risk factors. Here, we share dietary intake and diet quality results.<\/jats:p>\n Methods: This pilot single-blind, two-arm randomised control trial in Queensland, Australia, compared dietary intervention with usual care. Women in the intervention group received dietetic education to increase intake of foods improving gut microbiota health. Baseline and 36-week dietary intakes were assessed using the Australian Eating Survey and a Modified Short Dietary Questionnaire.<\/jats:p>\n Results: We randomised 129 women between 9- and 18-weeks\u2019 gestation. Baseline characteristics and dietary intakes showed no significant differences between groups (Table 1). However, dietary quality significantly improved in the intervention group, with higher vegetable, meat alternatives, fermented, and prebiotic food intake than controls.<\/jats:p>\n Conclusion: The HGD study successfully improved diet quality, diversity of plant-based foods and fermented and prebiotic food intakes in the intervention group compared with the control group at thirty-six-week gestation.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n H.M. O'Connor: None. S.J. de Jersey: None. S. Wilkinson: None. N.J. Meloncelli: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Office of Research and Innovation<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-600-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:15:21Z","timestamp":1749791721000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["600-P: The Healthy Gut Diet for Preventing Gestational Diabetes Improves Dietary Intake and Diet Quality"],"prefix":"10.2337","volume":"74","author":[{"given":"HANNAH M.","family":"O'CONNOR","sequence":"first","affiliation":[{"name":"Brisbane, Australia, Sunshine Coast, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUSAN J.","family":"DE JERSEY","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Sunshine Coast, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHELLEY","family":"WILKINSON","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Sunshine Coast, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NINA J.","family":"MELONCELLI","sequence":"additional","affiliation":[{"name":"Brisbane, Australia, Sunshine Coast, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/600-P\/158603\/600-P-The-Healthy-Gut-Diet-for-Preventing","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/600-P\/158603\/600-P-The-Healthy-Gut-Diet-for-Preventing","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T15:44:58Z","timestamp":1750434298000},"score":7.5792937,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/600-P\/158603\/600-P-The-Healthy-Gut-Diet-for-Preventing"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-600-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"600-P"},{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T13:40:08Z","timestamp":1648647608988},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_4","license":[{"start":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T00:00:00Z","timestamp":1576886400000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2019,12,20]]},"abstract":"Abstract<\/jats:title>\n Appropriately timed and directed balance responses are crucial for avoiding a fall. These responses, including feet-in-place adjustments of the centre of mass, stepping and gait adaptations, may be initiated voluntarily to proactively avoid falling or induced reactively in response to sudden external perturbations to balance. Despite good evidence that poor reactive balance responses contribute to falls and injuries, traditional fall prevention interventions have ignored this skill. Reactive balance (or perturbation) training intervention methods are emerging and show promise for preventing falls in older people, some evidence suggesting a 50% reduction in falls. We recruited 44 older adults into a parallel, blinded randomized controlled trial, comparing 3 sessions of reactive balance training (exposure to trips and slips) to one session of sham training. The primary outcome was falls following laboratory-induced trips and slips (&gt;30% body weight in harness). Relative to the control group, the intervention group experienced fewer total falls (rate ratio [RR]=0.40, 95% confidence interval [CI]=0.22-0.76), slip falls (RR=0.33, 95% CI=0.12-0.90) and trip falls (RR=0.49, 95% CI=0.21-1.12). These results will be discussed in the context of other current evidence for reactive balance training and suggestions made for how such interventions might influence the future of fall prevention.<\/jats:p>","DOI":"10.1093\/ageing\/afz164.159","type":"journal-article","created":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T05:07:58Z","timestamp":1576904878000},"page":"iv34-iv39","source":"Crossref","is-referenced-by-count":0,"title":["159 Reactive Balance Training for Preventing Falls in Older People"],"prefix":"10.1093","volume":"48","author":[{"given":"Daina","family":"Sturnieks","sequence":"first","affiliation":[{"name":"Neuroscience Research Australia (NeuRA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiro","family":"Okubo","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia (NeuRA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Brodie","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia (NeuRA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Lord","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia (NeuRA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,12,20]]},"container-title":["Age and Ageing"],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ageing\/article-pdf\/48\/Supplement_4\/iv34\/31578770\/afz164.159.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ageing\/article-pdf\/48\/Supplement_4\/iv34\/31578770\/afz164.159.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T05:07:58Z","timestamp":1576904878000},"score":7.5792937,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ageing\/article\/48\/Supplement_4\/iv34\/5682143"}},"issued":{"date-parts":[[2019,12]]},"references-count":0,"journal-issue":{"issue":"Supplement_4","published-online":{"date-parts":[[2019,12,20]]},"published-print":{"date-parts":[[2019,12,20]]}},"URL":"https:\/\/doi.org\/10.1093\/ageing\/afz164.159","ISSN":["0002-0729","1468-2834"],"issn-type":[{"value":"0002-0729","type":"print"},{"value":"1468-2834","type":"electronic"}],"published-other":{"date-parts":[[2019,12]]},"published":{"date-parts":[[2019,12]]}},{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T02:07:29Z","timestamp":1778983649664,"version":"3.51.4"},"publisher-location":"New York, NY, USA","reference-count":37,"publisher":"ACM","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,10,24]]},"DOI":"10.1145\/3626641.3627016","type":"proceedings-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T18:10:36Z","timestamp":1703700636000},"page":"119-128","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficient-YOLOv8: Multi-Scale ConvNet for Underwater Object Detection"],"prefix":"10.1145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-9172","authenticated-orcid":false,"given":"Lin","family":"Xu","sequence":"first","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2754-2104","authenticated-orcid":false,"given":"Hurriyatul","family":"Fitriyah","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4415-782X","authenticated-orcid":false,"given":"Craig","family":"Styan","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-6367","authenticated-orcid":false,"given":"Ivan","family":"Lee","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"320","published-online":{"date-parts":[[2023,12,27]]},"reference":[{"key":"e_1_3_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1109\/CVPRW59228.2023.00564"},{"key":"e_1_3_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoinf.2022.101847"},{"key":"e_1_3_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3844\/jcssp.2010.1088.1094"},{"key":"e_1_3_2_1_4_1","volume-title":"Yolov4: Optimal speed and accuracy of object detection. arXiv preprint arXiv:2004.10934","author":"Bochkovskiy Alexey","year":"2020","unstructured":"Alexey Bochkovskiy, Chien-Yao Wang, and Hong-Yuan\u00a0Mark Liao. 2020. Yolov4: Optimal speed and accuracy of object detection. arXiv preprint arXiv:2004.10934 (2020)."},{"key":"e_1_3_2_1_5_1","volume-title":"European conference on computer vision. Springer, 205\u2013218","author":"Cao Hu","year":"2022","unstructured":"Hu Cao, Yueyue Wang, Joy Chen, Dongsheng Jiang, Xiaopeng Zhang, Qi Tian, and Manning Wang. 2022. Swin-unet: Unet-like pure transformer for medical image segmentation. In European conference on computer vision. Springer, 205\u2013218."},{"key":"e_1_3_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucom.2019.11.023"},{"key":"e_1_3_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1109\/JSEN.2020.3013265"},{"key":"e_1_3_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1109\/CVPRW59228.2023.00133"},{"key":"e_1_3_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/nafm.10451"},{"key":"e_1_3_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neunet.2020.04.011"},{"key":"e_1_3_2_1_11_1","volume-title":"Fish4Knowledge: collecting and analyzing massive coral reef fish video data. Vol.\u00a0104","author":"Fisher B","unstructured":"Robert\u00a0B Fisher, Yun-Heh Chen-Burger, Daniela Giordano, Lynda Hardman, Fang-Pang Lin, 2016. Fish4Knowledge: collecting and analyzing massive coral reef fish video data. Vol.\u00a0104. Springer."},{"key":"e_1_3_2_1_12_1","volume-title":"Image dataset for benchmarking automated fish detection and classification algorithms. 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Marine Animal Detection and Recognition with Advanced Deep Learning Models.. In CLEF (Working Notes)."}],"event":{"name":"SIET 2023: International Conference on Sustainable Information Engineering and Technology","location":"Badung, Bali Indonesia","acronym":"SIET 2023"},"container-title":["Proceedings of the 8th International Conference on Sustainable Information Engineering and Technology"],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3626641.3627016","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3626641.3627016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T01:49:56Z","timestamp":1778982596000},"score":7.5792937,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3626641.3627016"}},"issued":{"date-parts":[[2023,10,24]]},"references-count":37,"alternative-id":["10.1145\/3626641.3627016","10.1145\/3626641"],"URL":"https:\/\/doi.org\/10.1145\/3626641.3627016","published":{"date-parts":[[2023,10,24]]},"assertion":[{"value":"2023-12-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T04:11:08Z","timestamp":1750997468953,"version":"3.41.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl_1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2024,11,12]]},"abstract":"\n Background:<\/jats:bold>\n Hypertrophic cardiomyopathy (HCM) is an inherited autosomal dominant disease of the sarcomere. Pathogenic features include ventricular hypertrophy, increased myofilament calcium sensitivity, myocardial fibrosis, and diastolic dysfunction. At the level of the myocyte there is cytoskeletal disarray, hypercontractility and altered mitochondrial function. Mitochondrial dysfunction is considered to be a key driver in HCM pathology.\n <\/jats:p>\n \n Research question:<\/jats:bold>\n We previously demonstrated that the L-type Ca\n 2+<\/jats:sup>\n channel plays a role in the development of HCM facilitated by a structural-functional communication with mitochondria that can be regulated via the alpha interaction domain (AID) of the channel. In search of a preventative HCM therapy, we explored the efficacy of amino acid peptide variants that correspond to the AID of the cardiac L-type Ca\n 2+<\/jats:sup>\n channel.\n <\/jats:p>\n \n Methods and Results:<\/jats:bold>\n Consistent with\n in silico predictions<\/jats:italic>\n , competition binding assays confirmed that 4 variant peptides bound with higher affinity to the beta subunit than the AID peptide.\n In vitro<\/jats:italic>\n studies confirmed that 3 of the 4 peptides could decrease the characteristic hypermetabolic state in myocytes isolated from a murine model of human HCM (\n cTnI-G203S<\/jats:italic>\n ).\n In vivo<\/jats:italic>\n treatment of\n cTnI-G203S<\/jats:italic>\n mice with peptide variants prevented the development of HCM and the development of fibrosis, in the absence of alterations in blood pressure, or kidney and liver function or changes in behaviour. Of note, the peptide variants also significantly improved contractile function. Similar effects were measured in\n \n \u03b1MHC\n 403\/+<\/jats:sup>\n <\/jats:italic>\n mice expressing the\n MYH6<\/jats:italic>\n mutation.\n <\/jats:p>\n \n Conclusions:<\/jats:bold>\n Here we describe a first in class therapy that uniquely targets the L-type Ca\n 2+<\/jats:sup>\n channel to modify mitochondrial function and prevent hypertrophic cardiomyopathy. The peptides may be effective for treatment of HCM broadly because the mechanism of action involves the modification of mitochondrial function and impaired energy metabolism that is a common characteristic and driver of the pathology.\n <\/jats:p>","DOI":"10.1161\/circ.150.suppl_1.4136614","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T13:17:35Z","timestamp":1731503855000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 4136614: The design of novel therapeutics that target the L-type calcium channel to prevent hypertrophic cardiomyopathy"],"prefix":"10.1161","volume":"150","author":[{"given":"Livia","family":"Hool","sequence":"first","affiliation":[{"name":"THE UNIVERSITY OF WESTERN AUSTRALIA, Crawley Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teagan","family":"Er","sequence":"additional","affiliation":[{"name":"THE UNIVERSITY OF WESTERN AUSTRALIA, Crawley Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Reinke","sequence":"additional","affiliation":[{"name":"THE UNIVERSITY OF WESTERN AUSTRALIA, Crawley Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Francis","sequence":"additional","affiliation":[{"name":"THE UNIVERSITY OF WESTERN AUSTRALIA, Crawley Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Solomon","sequence":"additional","affiliation":[{"name":"THE UNIVERSITY OF WESTERN AUSTRALIA, Crawley Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Viola","sequence":"additional","affiliation":[{"name":"UNIV WESTERN AUSTRALIA, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrietta","family":"Cserne Szappanos","sequence":"additional","affiliation":[{"name":"University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlyn","family":"Richworth","sequence":"additional","affiliation":[{"name":"THE UNIVERSITY OF WESTERN AUSTRALIA, Crawley Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khanh","family":"Vu","sequence":"additional","affiliation":[{"name":"THE UNIVERSITY OF WESTERN AUSTRALIA, Crawley Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"Jenkins","sequence":"additional","affiliation":[{"name":"THE UNIVERSITY OF WESTERN AUSTRALIA, Crawley Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Camacho Londono","sequence":"additional","affiliation":[{"name":"CSL Innovation, Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padmapriya","family":"Ponnuswamy","sequence":"additional","affiliation":[{"name":"CSL Behring Innovation GmbH, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciaran","family":"McFarlane","sequence":"additional","affiliation":[{"name":"University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Van Petegem","sequence":"additional","affiliation":[{"name":"University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1161\/circ.150.suppl_1.4136614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T14:08:36Z","timestamp":1750946916000},"score":7.5791574,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/circ.150.suppl_1.4136614"}},"issued":{"date-parts":[[2024,11,12]]},"references-count":0,"journal-issue":{"issue":"Suppl_1","published-print":{"date-parts":[[2024,11,12]]}},"alternative-id":["10.1161\/circ.150.suppl_1.4136614"],"URL":"https:\/\/doi.org\/10.1161\/circ.150.suppl_1.4136614","ISSN":["0009-7322","1524-4539"],"issn-type":[{"type":"print","value":"0009-7322"},{"type":"electronic","value":"1524-4539"}],"published":{"date-parts":[[2024,11,12]]},"assertion":[{"value":"2024-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:47:08Z","timestamp":1777657628506,"version":"3.51.4"},"reference-count":82,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Pediatric Health"],"published-print":{"date-parts":[[2019,1]]},"abstract":"\n While a known link between prenatal cannabis exposure and anencephaly exists, the relationship of prenatal cannabis exposure with neural tube defects (NTDs) generally has not been defined. Published data from Canada Health and Statistics Canada were used to assess this relationship. Both cannabis use and NTDs were shown to follow an east-west and north-south gradient. Last year cannabis consumption was significantly associated ( P < .0001; cannabis use\u2013time interaction P < .0001). These results were confirmed when estimates of termination for anomaly were used. Canada Health population data allowed the calculation of an NTD odds ratio) of 1.27 (95% confidence interval = 1.19-1.37; P < 10\n \u221211<\/jats:sup>\n ) for high-risk provinces versus the remainder with an attributable fraction in exposed populations of 16.52% (95% confidence interval = 12.22-20.62). Data show a robust positive statistical association between cannabis consumption as both a qualitative and quantitative variable and NTDs on a background of declining NTD incidence. In the context of multiple mechanistic pathways these strong statistical findings implicate causal mechanisms.\n <\/jats:p>","DOI":"10.1177\/2333794x19894798","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T09:41:57Z","timestamp":1576057317000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Cannabis Consumption Patterns Explain the East-West Gradient in Canadian Neural Tube Defect Incidence: An Ecological Study"],"prefix":"10.1177","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3256-720X","authenticated-orcid":false,"given":"Albert Stuart","family":"Reece","sequence":"first","affiliation":[{"name":"University of Western Australia, Crawley, Western Australia, Australia"},{"name":"Edith Cowan University, Joondalup, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary Kenneth","family":"Hulse","sequence":"additional","affiliation":[{"name":"University of Western Australia, Crawley, Western Australia, Australia"},{"name":"Edith Cowan University, Joondalup, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"key":"bibr1-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067103"},{"key":"bibr2-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.7"},{"key":"bibr3-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151586"},{"key":"bibr4-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/78.5.972"},{"key":"bibr5-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199801)57:1<1::AID-TERA1>3.0.CO;2-6"},{"key":"bibr6-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp395"},{"key":"bibr7-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.10.961"},{"key":"bibr8-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198530020-00003"},{"key":"bibr9-2333794X19894798","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0140-6736(91)90133-A","volume":"338","author":"Prevention of neural tube defects: results of the Medical Research Council Vitamin Study","year":"1991","journal-title":"Lancet"},{"key":"bibr10-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911113412001"},{"key":"bibr11-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212243272602"},{"key":"bibr12-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13548"},{"key":"bibr13-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13601"},{"key":"bibr14-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1007\/BF03194615"},{"key":"bibr15-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckl053"},{"key":"bibr16-2333794X19894798","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1136\/jech.45.1.52","volume":"45","author":"Prevalence of neural tube defects in 20 regions of Europe and the impact of prenatal diagnosis, 1980-1986","year":"1991","journal-title":"J Epidemiol Community Health"},{"key":"bibr17-2333794X19894798","first-page":"1","volume":"44","author":"Cragan JD","year":"1995","journal-title":"MMWR CDC Surveill Summ"},{"key":"bibr18-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1993.tb121690.x"},{"key":"bibr19-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1136\/jech.53.10.630"},{"key":"bibr20-2333794X19894798","unstructured":"Gilbert NL., De Wals P, Leon JA, Evans JA. 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Urgent and emerging issues in prevention: marijuana, kratom and E-cigarettes. https:\/\/www.samhsa.gov\/sites\/default\/files\/samhsas_15th_annual_prevention_day_afternoon_plenary_recording.pdf. Accessed November 28, 2019."},{"key":"bibr29-2333794X19894798","unstructured":"Substance Abuse and Mental Health Services Administration. National Survey on Drug Use and Health (NSDUH). https:\/\/www.samhsa.gov\/data\/data-we-collect\/nsduh-national-survey-drug-use-and-health. Accessed November 28, 2019."},{"key":"bibr30-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17225"},{"key":"bibr31-2333794X19894798","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002619"},{"key":"bibr32-2333794X19894798","unstructured":"Government of Canada. Canadian tobacco alcohol and drugs (CTADS): 2015 summary. https:\/\/www.canada.ca\/en\/health-canada\/services\/canadian-tobacco-alcohol-drugs-survey\/2015-summary.html. 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J Rural Health"],"published-print":{"date-parts":[[2024,4]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Dementia is now responsible for the greatest burden of disease of any chronic illness in older Australians. Rural and remote communities bear the impacts of this disproportionately. Additional training and education for healthcare staff to support people living with dementia is needed.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The objective of this scoping review was to map and synthesise the evidence related to barriers and enablers of accessing dementia training for Australian healthcare workers located in rural and remote areas.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n This scoping review systematically searched multiple databases in January 2023 for peer\u2010reviewed literature on the topic. Reviewers used Covidence to screen titles and abstracts of located sources, and to screen full\u2010text articles.<\/jats:p>\n <\/jats:sec>\n \n Findings<\/jats:title>\n From 187 articles screened, seven peer\u2010reviewed journal articles were included in the final data analysis; all were from Australia or Canada. The most common barrier described was low staffing, precluding release of staff for dementia training. Enablers to participation in dementia training were availability of online training programs, as well as training providers collaborating with end users to ensure the training met their learning needs.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n This review provides evidence of barriers and enablers specific to rural and remote healthcare workers accessing dementia training. It also explores other approaches to training that have been trialled successfully in different settings.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Addressing the identified barriers and enablers may assist in developing training approaches appropriate for existing staff, and in meeting training needs for the future workforce.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ajr.13090","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T02:14:15Z","timestamp":1709000055000},"page":"236-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Barriers and enablers of dementia training in healthcare workers in rural and remote Australia: A scoping review to inform future approaches to 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Less attention has been given to the effects of isolation for children's health and well\u2010being when experiencing DA. Based on the voices of young people who grew up in DA, the qualitative study that is the basis for this article asked young people about aspects of their childhood and what helped them to cope despite DA in their family of origin. The study found that methods of control used by the abuser led to children being isolated. At other times, children living with DA reported isolating themselves due to the effects of living with DA. Utilizing Vygotsky's sociocultural theory, children's isolation caused by DA is examined. The effects on children's social, emotional and educational well\u2010being are explored, and potential social work roles in helping children overcome such isolation are presented. We focus particularly on young people's call for connection with peers from similar backgrounds.<\/jats:p>","DOI":"10.1111\/cfs.13316","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T07:39:06Z","timestamp":1749627546000},"page":"735-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Imposed and Self\u2010Imposed Isolation Among Children and Young People Who Have Grown Up in Domestic Abuse"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4993-4958","authenticated-orcid":false,"given":"Fiona","family":"Buchanan","sequence":"first","affiliation":[{"name":"Justice and Society University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-6493","authenticated-orcid":false,"given":"Ashlee","family":"Borgkvist","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8997-8993","authenticated-orcid":false,"given":"Cathy","family":"Humphreys","sequence":"additional","affiliation":[{"name":"University of Melbourne Melbourne South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1366-065X","authenticated-orcid":false,"given":"Rebecca","family":"Regan\u2010Coe","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/1984\u20100462\/2022\/40\/2020385"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1524838019849582"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005\u20101473"},{"key":"e_1_2_12_5_1","volume-title":"Child Development","author":"Berk L.","year":"2015"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780429331053-4"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"e_1_2_12_8_1","volume-title":"Mothering Babies in DA: Beyond Attachment Theory","author":"Buchanan F.","year":"2018"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10896\u2010023\u201000647\u2010y"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/car.995"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/088626051561894611"},{"key":"e_1_2_12_12_1","unstructured":"Campo M. andS.Tayton.2015. \u201cDomestic and Family Violence in Regional Rural and Remote Communities.\u201d Australian Institute of Family Studies."},{"key":"e_1_2_12_13_1","unstructured":"Davies J. C.Singh M.Tebboth D.Spear A.Mensah andP.Ansah.2018. \u201cConducting Life History Interviews: A How\u2010to Guide.\u201d"},{"key":"e_1_2_12_14_1","volume-title":"Violence Against Wives: A Case Against the Patriarchy","author":"Dobash R. 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E.Vera\u2010Toscano F.Botha andS. C.Dahmann.2021. \u201cThe Household Income and Labour Dynamics in Australia Survey: Selected Findings From Waves 1 to 19.\u201d Melbourne Institute of Applied Economic & Social Research University of Melbourne.https:\/\/melbourneinstitute.unimelb.edu.au\/__data\/assets\/pdf_file\/0009\/3963249\/HILDA\u2010Statistical\u2010Report\u20102021.pdf."},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10567-019-00293-1"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11205\u2010016\u20101252\u20102"}],"container-title":["Child & Family Social Work"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cfs.13316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cfs.13316","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cfs.13316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T01:54:40Z","timestamp":1775440480000},"score":7.578977,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cfs.13316"}},"issued":{"date-parts":[[2025,6,11]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/cfs.13316"],"URL":"https:\/\/doi.org\/10.1111\/cfs.13316","archive":["Portico"],"ISSN":["1356-7500","1365-2206"],"issn-type":[{"value":"1356-7500","type":"print"},{"value":"1365-2206","type":"electronic"}],"published":{"date-parts":[[2025,6,11]]},"assertion":[{"value":"2024-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T05:46:14Z","timestamp":1762062374497},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_5","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2016,6,1]]},"abstract":"Abstract<\/jats:title>\n BACKGROUND: Urinary tract infection is one of the commonest paedi-atric infections, and important to diagnose or exclude in young children with fever. Limitations exist with all current urine collection methods, guidelines vary, and clinicians have different preferences. Clean catch urine (CCU) is a preferred non-invasive collection method and is convenient and painless compared to suprapubic aspirate and catheterisation. However, it can be unreliable and time-consuming, with high rates of sample contamination and collection failure. Only 12% void within 5 minutes based on recent data. An ideal method of urine collection would be fast, reliable and simple. Suprapubic stimulation may trigger involuntary parasympathetic detrusor contraction, inducing voiding via early childhood exteroceptive somato-bladder reflexes.<\/jats:p>\n OBJECTIVES: We conducted a pilot study using a novel method (termed \u2018Quick-Wee\u2019) of gentle cutaneous suprapubic stimulation with saline-soaked gauze, to hasten voiding for non-invasive urine collection.<\/jats:p>\n DESIGN\/METHODS: Prospective pilot study of 40 pre-continent children age 1-24 months requiring CCU in a paediatric emergency department in Australia. Standard CCU was augmented by 5 minutes of suprapubic cutaneous stimulation (Quick-Wee method), with either cold (3 degrees Celsius) or room-temperature saline-soaked gauze. PRIMARY OUTCOME: Void &lt;5 minutes. SECONDARY OUTCOMES: Successful catch of sample (if voids), contamination rate, parental\/clinician satisfaction with technique.<\/jats:p>\n RESULTS:<\/jats:p>\n \n CONCLUSION: Gentle cutaneous suprapubic stimulation with saline-soaked gauze appears to be a promising technique with 30% voiding in &lt;5 minutes, a rate higher than observed without such stimulation. A randomised controlled trial comparing Quick-Wee to standard CCU without suprapubic stimulation is now underway.<\/jats:p>","DOI":"10.1093\/pch\/21.supp5.e95","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T18:18:03Z","timestamp":1663697883000},"page":"e95-e95","source":"Crossref","is-referenced-by-count":1,"title":["Quick-Wee: A Novel Non-Invasive Urine Collection Method for Infants in the Emergency Department"],"prefix":"10.1093","volume":"21","author":[{"given":"J","family":"Kaufman","sequence":"first","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Tosif","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Donath","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Hopper","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Bryant","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Babl","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,6,1]]},"container-title":["Paediatrics & Child Health"],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pch\/article-pdf\/21\/Supplement_5\/e95\/45668386\/pche95.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pch\/article-pdf\/21\/Supplement_5\/e95\/45668386\/pche95.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T18:18:05Z","timestamp":1663697885000},"score":7.5789113,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pch\/article\/21\/Supplement_5\/e95\/6687521"}},"issued":{"date-parts":[[2016,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_5","published-online":{"date-parts":[[2016,6,1]]},"published-print":{"date-parts":[[2016,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/pch\/21.supp5.e95","ISSN":["1918-1485","1205-7088"],"issn-type":[{"value":"1918-1485","type":"electronic"},{"value":"1205-7088","type":"print"}],"published-other":{"date-parts":[[2016,6,1]]},"published":{"date-parts":[[2016,6,1]]}},{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T01:28:03Z","timestamp":1776043683441,"version":"3.50.1"},"reference-count":75,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"am","delay-in-days":353,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T00:00:00Z","timestamp":1586563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP0558681"],"award-info":[{"award-number":["DP0558681"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["LP160100333"],"award-info":[{"award-number":["LP160100333"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009034","name":"Sea World Research and Rescue Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009034","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"Abstract<\/jats:title>\n \n In this study, we investigated the visual system of the Port Jackson shark\n Heterodontus portusjacksoni<\/jats:italic>\n , a shallow\u2010dwelling benthic species and generalist predator endemic to the temperate coastal waters around southern Australia. Measurements of retinal spectral sensitivity in juvenile sharks, made using single flash and heterochromatic flicker photometry under conditions of dark\u2010 or light\u2010adaptation, indicated a peak sensitivity at around 500\u2009nm, with no evidence of a spectral shift with increasing levels of light adaptation. Histological sections of the retina revealed a heavily rod dominated retina containing only a few small cell profiles in the photoreceptor layer that might represent a sparse cone population or may be immature rods. Assessment of retinal topography in juvenile sharks indicated the presence of a distinct specialisation for increased visual spatial acuity in the form of a horizontal streak of higher rod photoreceptor (~80,000 rods mm\n \u22122<\/jats:sup>\n ) and ganglion cell (~1,800 cells mm\n \u22122<\/jats:sup>\n ) densities across the horizontal meridian of the eye. This specialization would be adaptive for panoramic sampling of the part of the visual field corresponding to the substrate\u2010water interface and remove the need for\n H. portusjacksoni<\/jats:italic>\n to move its eyes extensively when resting on the sea floor. The estimated upper limit of spatial resolving power in juvenile\n H. portusjacksoni<\/jats:italic>\n was 3.14\u2009cycles\u2009deg\n \u22121<\/jats:sup>\n , which is at the lower end of values measured in elasmobranchs. Taken together, these results suggest that the retina of\n H. portusjacksoni<\/jats:italic>\n is well adapted for nocturnal vision.\n <\/jats:p>","DOI":"10.1002\/cne.24911","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T06:46:20Z","timestamp":1585550780000},"page":"2831-2847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Retinal topography and spectral sensitivity of the Port Jackson shark (\n \n Heterodontus portusjacksoni<\/i>\n <\/scp>\n )"],"prefix":"10.1002","volume":"528","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6960-5663","authenticated-orcid":false,"given":"Lauren R.","family":"Peel","sequence":"first","affiliation":[{"name":"School of Biological Sciences University of Western Australia Crawley Western Australia Australia"},{"name":"The Oceans Institute University of Western Australia Crawley Western Australia Australia"},{"name":"The Oceans Graduate School University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun P.","family":"Collin","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of Western Australia Crawley Western Australia Australia"},{"name":"The Oceans Institute University of Western Australia Crawley Western Australia Australia"},{"name":"The Oceans Graduate School University of Western Australia Crawley Western Australia Australia"},{"name":"School of Life Sciences, La Trobe University Bundoora Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7289-9399","authenticated-orcid":false,"given":"Nathan S.","family":"Hart","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of Western Australia Crawley Western Australia Australia"},{"name":"Department of Biological Sciences Macquarie University Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.1986.4767749"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1071\/MF16122"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1998.143"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(94)90015-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000006652"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(77)90120-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/15.9.19"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092310"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21992"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12823"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000116595"},{"key":"e_1_2_7_13_1","first-page":"269","volume-title":"Bullhead, mackerel and carpet sharks (Heterodontiformes, Lamniformes and Orectolobiformes). 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Despite both being simultaneously relevant to future agricultural systems, the two are usually studied separately. By contrast, this study jointly compares the potential impacts of climate change and the effects of mitigation policy on farming systems in the central region of Western Australia\u2019s grainbelt, using the results of several biophysical models integrated into a whole\u2010farm bioeconomic model. In particular, we focus on the potential for interactions between climate impacts and mitigation activities. Results suggest that, in the study area, farm profitability is much more sensitive to changes in climate than to a mitigation policy involving a carbon price on agricultural emissions. Climate change reduces the profitability of agricultural production and, as a result, reduces the opportunity cost of reforesting land for carbon sequestration. Nonetheless, the financial attractiveness of reforestation does not necessarily improve because climate change also reduces tree growth and, therefore, the income from sequestration. Consequently, at least for the study area, climate change has the potential to reduce the amount of abatement obtainable from sequestration \u2013 a result potentially relevant to the debate about the desirability of sequestration as a mitigation option.<\/jats:p>","DOI":"10.1111\/1467-8489.12330","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T07:01:13Z","timestamp":1567580473000},"page":"841-865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Climate change reduces the mitigation obtainable from sequestration in an Australian farming system"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3463-6299","authenticated-orcid":false,"given":"Tas","family":"Thamo","sequence":"first","affiliation":[{"name":"University of Western Australia School of Agriculture and Environment University of Western Australia Crawley Western Australia Australia"},{"name":"University of Western Australia Centre for Environmental Economics and Policy University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donkor","family":"Addai","sequence":"additional","affiliation":[{"name":"University of Western Australia School of Agriculture and Environment University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6847-4817","authenticated-orcid":false,"given":"Marit E.","family":"Kragt","sequence":"additional","affiliation":[{"name":"University of Western Australia School of Agriculture and Environment University of Western Australia Crawley Western Australia Australia"},{"name":"University of Western Australia Centre for Environmental Economics and Policy University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross S.","family":"Kingwell","sequence":"additional","affiliation":[{"name":"University of Western Australia School of Agriculture and Environment University of Western Australia Crawley Western Australia Australia"},{"name":"Australian Export Grains Innovation Centre South Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Pannell","sequence":"additional","affiliation":[{"name":"University of Western Australia School of Agriculture and Environment University of Western Australia Crawley Western Australia Australia"},{"name":"University of Western Australia Centre for Environmental Economics and Policy University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Robertson","sequence":"additional","affiliation":[{"name":"University of Western Australia School of Agriculture and Environment University of Western Australia Crawley Western Australia Australia"},{"name":"CSIRO Agriculture Floreat Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Agricultural Commodity Statistics 2013","author":"ABARES","year":"2013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4290(03)00154-0"},{"key":"e_1_2_6_4_1","unstructured":"Australian Government(2019).Emissions Reduction Fund - Overview. 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The main aims of this clinic were to improve healthcare efficiency and standardize follow\u2010up processes.<\/jats:p><\/jats:sec>Objectives<\/jats:title>The primary objective was to assess the effectiveness of a nurse\u2010led renal cell cancer follow up clinic in regard to surveillance protocol compliance and the timely identification and appropriate management of recurrences. A secondary objective was to evaluate this locally developed follow up protocol against the current European Association of Urology (EAU) guidelines surveillance protocol.<\/jats:p><\/jats:sec>Patient and Methods<\/jats:title>All patients who underwent a partial or radical nephrectomy between 2015 and 2021 at a single Western Australia institution for a primary renal malignancy were included. Data was collected from local clinical information systems and protocol adherence, recurrence characteristics and management were assessed. The current EAU guidelines were applied to the cohort to assess differences in risk\u2010stratification and theoretical outcomes between the protocols.<\/jats:p><\/jats:sec>Results<\/jats:title>After a mean follow up period of 31.2\u2009months (range 0\u201377\u2009months), 75.5% (185\/245) of patients had all follow up imaging and reviews within 1 month of the timeframe scheduled on the protocol. 17.1% (42\/245) had a delay in their follow up of more than a month at some stage, 5.7% (14\/245) did not attend for follow up but had documented attempts to facilitate their compliance, and 0.4% (1\/245) were lost to follow up with no evidence of attempted contact. 15.5% (38\/245) of patients had recurrence of malignancy detected during follow up and these were all discussed in a multi\u2010disciplinary team (MDT) meeting. The recurrence rate was 2.5% (3\/119) for low risk, 17.7% (14\/79) for intermediate risk, and 44.7% (21\/47) for high risk patients when they were re\u2010stratified according to EAU risk categories. No recurrences were detected through ultrasound (USS) or chest x\u2010ray (CXR) in this cohort and our protocol tended to place patients in higher risk\u2010stratification groups as compared to current EAU guidelines.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Nurse\u2010led renal cell cancer follow up is a safe, reliable and effective clinical framework that has significant benefits in regard to resource utilization. USS and CXR are ineffective in detecting recurrence and Computerized tomography (CT) should be considered the imaging modality of choice for this purpose. The EAU surveillance protocol appears superior to our protocol, and we have therefore transitioned to the EAU guideline protocol going forward.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18920","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T10:37:55Z","timestamp":1709289475000},"page":"1071-1075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nurse\u2010led renal cell carcinoma clinic: a single center review"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9718-4178","authenticated-orcid":false,"given":"I.","family":"Thia","sequence":"first","affiliation":[{"name":"Urology Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tan","sequence":"additional","affiliation":[{"name":"Urology Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Botha","sequence":"additional","affiliation":[{"name":"Urology Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Picardo","sequence":"additional","affiliation":[{"name":"Urology Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Urology Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Thyer","sequence":"additional","affiliation":[{"name":"Urology Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Abdul\u2010Hamid","sequence":"additional","affiliation":[{"name":"Urology Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tan","sequence":"additional","affiliation":[{"name":"Urology Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Teichmann","sequence":"additional","affiliation":[{"name":"Urology Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Hayne","sequence":"additional","affiliation":[{"name":"Urology Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.P.","family":"McCombie","sequence":"additional","affiliation":[{"name":"Urology Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Australian Institute of Health and Welfare.Cancer data in Australia [Internet]. 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We identified the top 10 patient and carer research priorities for children with Down syndrome.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A modified James Lind Alliance method was used. A first online survey generated ideas, which were collated, and a longlist was created. A second online survey prioritised the longlist. This was done for clinicians and patient and carers separately. A single consensus meeting was held with carers, and a final consensus list of top 10 patient and carer priorities emerged. The surveys were developed in Qualtrics, a survey research platform. Patient and carers were invited to participate through poster advertising and social media posts. National consumer organisations were approached. Clinicians were invited through email and via Twitter.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Online with a single in-person consensus meeting.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n 339 research ideas were submitted from 117 patient and carers and 89 clinicians in the idea-generating survey. These were consolidated into 20 research ideas\/themes for the separate patient and carer and clinician prioritisation surveys. 85 patient and carer responses and 98 clinician responses were received to the prioritisation survey. The consensus meeting produced the final 10 patient and carer research priorities. The top two priorities were as follows: (1) developing a gold standard model of care including screening health checks across all levels of care and (2) sleep quality (including obstructive sleep apnoea, snoring, breathing problems and circadian rhythm).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study has given patient and carers the opportunity to determine a patient and carer priority list for clinical care and research for children with Down syndrome.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/archdischild-2024-328319","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T07:10:06Z","timestamp":1741331406000},"page":"729-736","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Patient and carer priorities for research and clinical care of children with Down syndrome"],"prefix":"10.1136","volume":"110","author":[{"given":"Ellen","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of General Paediatrics, Perth Children\u2019s Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8418-5572","authenticated-orcid":false,"given":"Aine","family":"Sommerfield","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, Nedlands, Western Australia, Australia"},{"name":"Department of Anaesthesia and Pain Medicine, Perth Children\u2019s Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda","family":"Frank","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Wilcox","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Rajarathnan","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics, Perth Children\u2019s Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Sheil","sequence":"additional","affiliation":[{"name":"Down Syndrome WA, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra","family":"Hughes","sequence":"additional","affiliation":[{"name":"Down Syndrome WA, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikki","family":"Schwagermann","sequence":"additional","affiliation":[{"name":"Down Syndrome WA, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta S","family":"von Ungern-Sternberg","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Medicine, Perth Children\u2019s Hospital, Perth, Western Australia, Australia"},{"name":"The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"2025112723350930000_110.9.729.1","first-page":"125","article-title":"Down Syndrome: Current Status, Challenges and Future Perspectives","volume":"5","author":"Kazemi","year":"2016","journal-title":"Int J Mol Cell Med"},{"key":"2025112723350930000_110.9.729.2","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.749046","article-title":"Development of Down Syndrome Research Over the Last Decades-What Healthcare and Education Professionals Need to Know","volume":"12","author":"Windsperger","year":"2021","journal-title":"Front Psychiatry"},{"key":"2025112723350930000_110.9.729.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.gim.2022.08.029"},{"key":"2025112723350930000_110.9.729.4","unstructured":"Down syndrome Austalia. population statistics 2023. 2024. 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However, species differences (including nocturnal behavior) and standard housing below the thermoneutral zone (TNZ; 26\u00b0C\u201334\u00b0C) can confound comparisons. This systematic review evaluates methodologies, including housing temperatures, used in mouse heat\u2010exposure studies published over the past 4\u2009years. Medline, Web of Science, and Embase were searched for peer\u2010reviewed mouse heat\u2010exposure studies published from 2020 to 10 January 2025. Data on housing temperature, heat\u2010exposure protocols, and physiological outcomes were extracted. Screening and extraction were conducted independently and in duplicate in Covidence. One hundred seventy studies were included. Of those, 142 (83%) housed control mice below TNZ; seven (4%) studies maintained TNZ conditions and the remainder did not report control temperature. Heat exposures ranged from 30\u00b0C\u201345\u00b0C, most commonly 39\u00b0C\u201341\u00b0C. Body temperature was measured in 110 (65%) studies, often targeting ~42\u00b0C. When timing was reported, exposures occurred mainly during the light phase (52, 30%). Most studies used males only (116, 68%); 31 (18%) used females only; 9 (5%) included both sexes; and 14 (8%) did not report sex. Common outcomes were digestive (55, 32%), inflammatory (47, 28%), and central nervous system (40, 24%). Recent mouse heat\u2010exposure studies often compare heat\u2010exposed animals with cold\u2010stressed controls and apply daytime exposures that conflict with the nocturnal behavior of mice and human diurnal pattern. Incomplete reporting of housing conditions limits interpretation. Future research should account for differences between mice and humans to improve translational relevance.<\/jats:p>\n \n Trial Registration:<\/jats:bold>\n PROSPERO<\/jats:ext-link>\n : CRD42024611316\n <\/jats:p>","DOI":"10.1111\/apha.70281","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:21:32Z","timestamp":1784863292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Under Control? Mouse Models of Heat Exposure: A Systematic Review of Experimental Design and Methodology"],"prefix":"10.1111","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2856-4525","authenticated-orcid":false,"given":"Amina H.","family":"Rhaman","sequence":"first","affiliation":[{"name":"School of Population & Global Health, University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4074-5512","authenticated-orcid":false,"given":"Leaf R.","family":"Kardol","sequence":"additional","affiliation":[{"name":"School of Human Sciences, University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5878-2266","authenticated-orcid":false,"given":"Shane K.","family":"Maloney","sequence":"additional","affiliation":[{"name":"School of Human Sciences, University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3065-2857","authenticated-orcid":false,"given":"Ebony","family":"Quintrell","sequence":"additional","affiliation":[{"name":"School of Population & Global Health, University of Western Australia Perth Western Australia Australia"},{"name":"The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3814-1641","authenticated-orcid":false,"given":"Elizabeth","family":"Sorial","sequence":"additional","affiliation":[{"name":"School of Population & Global Health, University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2233-0383","authenticated-orcid":false,"given":"Shannon","family":"Morgan","sequence":"additional","affiliation":[{"name":"Medical School, University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3366-4415","authenticated-orcid":false,"given":"Danielle J.","family":"Russell","sequence":"additional","affiliation":[{"name":"School of Population & Global Health, University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0841-2216","authenticated-orcid":false,"given":"Erin","family":"Kelty","sequence":"additional","affiliation":[{"name":"School of Population & Global Health, University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5746-5680","authenticated-orcid":false,"given":"Caitlin S.","family":"Wyrwoll","sequence":"additional","affiliation":[{"name":"School of Human Sciences, University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"World Health O \u201cThe Synergies of Heat Stress and Air Pollution and Its Health Impacts: Technical Brief \u201d(2025)."},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01822-1"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.4155\/fso.15.63"},{"issue":"3","key":"e_1_2_13_5_1","first-page":"207","article-title":"The Mighty Mouse: The Impact of Rodents on Advances in Biomedical Research","volume":"110","author":"Bryda E. 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J.","year":"2004","journal-title":"Comparative Medicine"},{"key":"e_1_2_13_54_1","doi-asserted-by":"crossref","unstructured":"S.Sardar \u201cEffect of Age on Physiological Heat Strain During Hot and Humid Heat Exposure \u201d(2025).","DOI":"10.1152\/physiol.2025.40.S1.0152"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2009.02.002"}],"container-title":["Acta Physiologica"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.70281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apha.70281","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apha.70281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T02:53:13Z","timestamp":1785120793000},"score":7.577591,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.70281"}},"issued":{"date-parts":[[2026,7,23]]},"references-count":54,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/apha.70281"],"URL":"https:\/\/doi.org\/10.1111\/apha.70281","archive":["Portico"],"ISSN":["1748-1708","1748-1716"],"issn-type":[{"value":"1748-1708","type":"print"},{"value":"1748-1716","type":"electronic"}],"published":{"date-parts":[[2026,7,23]]},"assertion":[{"value":"2026-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70281"},{"indexed":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:38:43Z","timestamp":1714696723475},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"9_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,5,2]]},"abstract":"Abstract<\/jats:title>\n Background - An inverse association has been described in a number of studies between mammographic breast density (MBD) and pathologic complete response (pCR) following neoadjuvant chemotherapy (NAC) for early breast cancer (BC), implicating high MBD in chemotherapy resistance. However, this effect has not been seen in all there is a paucity of data exploring whether this relationship extends the relationship beyond pCR to overall survival. This study aims to validate the relationship between MBD and pCR in patients undergoing NAC for early BC as well as to assess the relation of MBD with clinical complete response (cCR), relapse-free (RFS) and BC-specific survival (BCSS). Further, this study examines these associations stratified by body mass index (BMI).<\/jats:p>\n Methods - MBD was measured in contralateral mammograms in 127 women before NAC, using Cumulus software. As the study spanned the transition period from film to digital mammography, film mammograms were digitised using a high-powered scanner and processed full-field digital mammograms were extracted from the imaging storage facility. Basic patient, tumour and treatment demographics were collated including BMI. Percent dense area (PDA) was correlated with patient and tumour characteristics, short-term (pCR\/cCR incidences), and long-term chemotherapy outcomes (RFS and BCSS).<\/jats:p>\n Results - Overall rates of cCR and pCR of 49% and 21% were observed across the whole cohort. Mean PDA was higher in those not undergoing cCR (p=0.041) and relapsing patients (p=0.041) but did not significantly vary by pCR or BC-deaths. As a dichotomous variable, high PDA relative to low PDA corresponded to lower cCR (40 v 58%, p=0.027), but no significant difference was seen for pCR (17.5 v 25.0%, p=0.15), BC relapse (38 v 30%, p=0.15) or BC-death (32 v 25%, p=0.20). High PDA (relative to low PDA) in patients with obesity (BMI &gt;30kg\/m2) was associated with lower pCR (0% v 28.1%, p=0.036) and numerically higher relapse rates (56% v 28%, p=0.063) and breast cancer deaths (56 v 28%, p=0.071. No such relationship was observed in patients with a BMI&lt; 30kg\/m2.<\/jats:p>\n Conclusion - Higher MBD associated with lower cCR and higher relapse but not with pCR or BC death. The inferior outcomes with high MBD were confined to patients with obesity in our study. Further analysis of the relationship between MBD and outcomes, including by BMI, is warranted.<\/jats:p>\n Citation Format: Andrew Redfern, Veenoo Agarwal, Ellie Darcey, Lisa Spalding, Hilary Martin, Jennifer Stone. Obesity May Modulate the Relationship Between High Mammographic Breast Density and Neoadjuvant Chemoresistance in Early Breast Cancer [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO2-23-10.<\/jats:p>","DOI":"10.1158\/1538-7445.sabcs23-po2-23-10","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T06:50:38Z","timestamp":1714632638000},"page":"PO2-23-10-PO2-23-10","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract PO2-23-10: Obesity May Modulate the Relationship Between High Mammographic Breast Density and Neoadjuvant Chemoresistance in Early Breast Cancer"],"prefix":"10.1158","volume":"84","author":[{"given":"Andrew","family":"Redfern","sequence":"first","affiliation":[{"name":"1University of Western Australia, Perth, Western Australia, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veenoo","family":"Agarwal","sequence":"additional","affiliation":[{"name":"2Fiona Stanley Hospital, Perth, Western Australia, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellie","family":"Darcey","sequence":"additional","affiliation":[{"name":"3University of Western Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Spalding","sequence":"additional","affiliation":[{"name":"4Harry Perkins institute for Medical Research, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Martin","sequence":"additional","affiliation":[{"name":"2Fiona Stanley Hospital, Perth, Western Australia, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Stone","sequence":"additional","affiliation":[{"name":"1University of Western Australia, Perth, Western Australia, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/84\/9_Supplement\/PO2-23-10\/745009\/Abstract-PO2-23-10-Obesity-May-Modulate-the","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/84\/9_Supplement\/PO2-23-10\/745009\/Abstract-PO2-23-10-Obesity-May-Modulate-the","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T06:50:39Z","timestamp":1714632639000},"score":7.5772805,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/84\/9_Supplement\/PO2-23-10\/745009\/Abstract-PO2-23-10-Obesity-May-Modulate-the"}},"issued":{"date-parts":[[2024,5,2]]},"references-count":0,"journal-issue":{"issue":"9_Supplement","published-print":{"date-parts":[[2024,5,2]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.sabcs23-po2-23-10","ISSN":["1538-7445"],"issn-type":[{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2024,5,2]]}},{"indexed":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T05:15:55Z","timestamp":1678511755113},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Supplement 4","content-domain":{"domain":["www.auajournals.org"],"crossmark-restriction":true},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1097\/01.ju.0000556687.54578.24","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T05:40:57Z","timestamp":1556084457000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["MP54-08\u2003LATE BIOCHEMICAL RECURRENCE POST-PROSTATECTOMY IS ASSOCIATED WITH A SLOWER RATE OF PROGRESSION"],"prefix":"10.1097","volume":"201","author":[{"given":"Ken","family":"Chow*","sequence":"first","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Herrera","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Stuchbery","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin S.","family":"Peters","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Costello","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Hovens","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niall M.","family":"Corcoran","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"http:\/\/www.auajournals.org\/doi\/pdf\/10.1097\/01.JU.0000556687.54578.24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T16:37:51Z","timestamp":1678466271000},"score":7.577213,"resource":{"primary":{"URL":"http:\/\/www.auajournals.org\/doi\/10.1097\/01.JU.0000556687.54578.24"}},"issued":{"date-parts":[[2019,4]]},"references-count":0,"journal-issue":{"issue":"Supplement 4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1097\/01.JU.0000556687.54578.24"],"URL":"https:\/\/doi.org\/10.1097\/01.ju.0000556687.54578.24","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"2019-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:05:59Z","timestamp":1761919559048},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["neurology.org"],"crossmark-restriction":true},"short-container-title":["Neurology"],"published-print":{"date-parts":[[2005,4,12]]},"DOI":"10.1212\/wnl.64.7.1317-a","type":"journal-article","created":{"date-parts":[[2012,5,13]],"date-time":"2012-05-13T14:32:21Z","timestamp":1336919541000},"page":"1317","update-policy":"http:\/\/dx.doi.org\/10.1212\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Recombinant hepatitis B vaccine and the risk of multiple sclerosis: A prospective study"],"prefix":"10.1212","volume":"64","author":[{"given":"C. R.","family":"MacIntyre","sequence":"first","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Jolley","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Butzkueven","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Salmon","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Halsey","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. H.","family":"Moulton","sequence":"additional","affiliation":[{"name":"Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_4_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000138433.61870.82"},{"key":"e_1_4_3_1_3_2","first-page":"79","year":"1998","unstructured":"Goldberg D, McMenamin J. The United Kingdom'ss hepatitis B vaccination strategy\u2014where now? Communicable Dis Public Health 1998;1:79\u201383.","journal-title":"Communicable Dis Public Health"},{"key":"e_1_4_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1258\/0956462021924929"},{"key":"e_1_4_3_1_5_2","first-page":"218","volume":"2","year":"1999","unstructured":"Dunn J, Shukla R, Neal K. Survey of neonatal hepatitis B vaccination in Leicestershire. Communicable Dis Public Health 1999;2:218\u2013219.","journal-title":"Communicable Dis Public Health"},{"key":"e_1_4_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000110294"},{"key":"e_1_4_3_1_7_2","unstructured":"Institute of Medicine. Hepatitis B vaccine and demyelinating neurological disorders. In: Stratton K Almario DA McCormick MC eds. Immunization safety review. Washington DC: The National Academies Press 2002."},{"key":"e_1_4_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.4.504"},{"key":"e_1_4_3_1_9_2","first-page":"S143","volume":"13","year":"2004","unstructured":"DeStefano F, Weintraub ES, Chen RT. Determining risk of multiple sclerosis after hepatitis B vaccine: time since vaccination and source of data. Pharmacoepidemiol Drug Safety 2004;13:S143.","journal-title":"Pharmacoepidemiol Drug Safety"}],"container-title":["Neurology"],"language":"en","link":[{"URL":"https:\/\/www.neurology.org\/doi\/pdfdirect\/10.1212\/WNL.64.7.1317-a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T16:15:07Z","timestamp":1711642507000},"score":7.577213,"resource":{"primary":{"URL":"https:\/\/www.neurology.org\/doi\/10.1212\/WNL.64.7.1317-a"}},"issued":{"date-parts":[[2005,4,12]]},"references-count":8,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,4,12]]}},"alternative-id":["10.1212\/WNL.64.7.1317-a"],"URL":"https:\/\/doi.org\/10.1212\/wnl.64.7.1317-a","ISSN":["0028-3878","1526-632X"],"issn-type":[{"value":"0028-3878","type":"print"},{"value":"1526-632X","type":"electronic"}],"published":{"date-parts":[[2005,4,12]]}},{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:26:29Z","timestamp":1787700389444,"version":"build-2784847793"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"published-print":{"date-parts":[[1997,2,15]]},"abstract":"The aim of this study was to determine the role of the phosphorylation state of glycogen synthase and glycogen phosphorylase in the regulation of muscle glycogen repletion in fasted animals recovering from high-intensity exercise. Groups of rats were swum to exhaustion and allowed to recover for up to 120 min without access to food. Swimming to exhaustion caused substantial glycogen breakdown and lactate accumulation in the red, white and mixed gastrocnemius muscles, whereas the glycogen content in the soleus muscle remained stable. During the first 40 min of recovery, significant repletion of glycogen occurred in all muscles examined except the soleus muscle. At the onset of recovery, the activity ratios and fractional velocities of glycogen synthase in the red, white and mixed gastrocnemius muscles were higher than basal, but returned to pre-exercise levels within 20 min after exercise. In contrast, after exercise the activity ratios of glycogen phosphorylase in the same muscles were lower than basal, and increased to pre-exercise levels within 20 min. This pattern of changes in glycogen synthase and phosphorylase activities, never reported before, suggests that the integrated regulation of the phosphorylation state of both glycogen synthase and phosphorylase might be involved in the control of glycogen deposition after high-intensity exercise.<\/jats:p>","DOI":"10.1042\/bj3220303","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T21:53:23Z","timestamp":1439243603000},"page":"303-308","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Regulation of glycogen synthase and phosphorylase during recovery from high-intensity exercise in the rat"],"prefix":"10.1042","volume":"322","author":[{"given":"Lambert","family":"BR\u00c4U","sequence":"first","affiliation":[{"name":"Departments of Biochemistry, University of Western Australia, Nedlands, Western Australia 6907, Australia"},{"name":"Departments of Human Movement, University of Western Australia, Nedlands, Western Australia 6907, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis D. M. C. B.","family":"FERREIRA","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry, University of Western Australia, Nedlands, Western Australia 6907, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"NIKOLOVSKI","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry, University of Western Australia, Nedlands, Western Australia 6907, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazala","family":"RAJA","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry, University of Western Australia, Nedlands, Western Australia 6907, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Norman","family":"PALMER","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry, University of Western Australia, Nedlands, Western Australia 6907, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"FOURNIER","sequence":"additional","affiliation":[{"name":"Departments of Human Movement, University of Western Australia, Nedlands, Western Australia 6907, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Biochemical Journal"],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/322\/1\/303\/624091\/bj3220303.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/322\/1\/303\/624091\/bj3220303.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:28:41Z","timestamp":1637713721000},"score":7.5771723,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/322\/1\/303\/33709\/Regulation-of-glycogen-synthase-and-phosphorylase"}},"issued":{"date-parts":[[1997,2,15]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,2,15]]}},"URL":"https:\/\/doi.org\/10.1042\/bj3220303","ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"published":{"date-parts":[[1997,2,15]]}},{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:26:32Z","timestamp":1784629592664,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001801","name":"University of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian J Rural Health"],"published-print":{"date-parts":[[2022,4]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To measure satisfaction with general practitioner obstetrician\u2010led maternity care in Western Australia and to explore perspectives of maternity service users<\/jats:p><\/jats:sec>Design<\/jats:title>Women were recruited at antenatal visits with their general practitioner obstetrician. Participants completed a validated three\u2010part survey about their satisfaction with antenatal, intrapartum and postpartum care. They were all offered a semi\u2010structured interview.<\/jats:p><\/jats:sec>Setting<\/jats:title>Nine general practitioner obstetrician practices located in regional Western Australia.<\/jats:p><\/jats:sec>Participants<\/jats:title>155 women receiving general practitioner obstetrician\u2010led maternity care within the South West or Great Southern regions of Western Australia. 13 of these women also participated in an interview.<\/jats:p><\/jats:sec>Main Outcome Measures<\/jats:title>We quantified satisfaction with aspects of antenatal, intrapartum and postpartum care using a Likert scale. Descriptive variables included demographic information and birth outcomes. Qualitative data described valued aspects of maternity care.<\/jats:p><\/jats:sec>Results<\/jats:title>116 women completed all 3 surveys. General practitioner obstetrician\u2010led care resulted in high rates of satisfaction across all 3 stages of care, with 78%\u2010100% agreement with positively worded satisfaction statements. Thematic analysis identified four key aspects of care women valued when receiving maternity care: the woman\u2010centred care experience, the skills of the general practitioner obstetrician, support from the health care team and the health care environment.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>General practitioner obstetrician\u2010led maternity care is a highly regarded model of maternity care, valued by rural women with high rates of satisfaction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajr.12783","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T08:31:04Z","timestamp":1631521864000},"page":"135-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Satisfaction with general practitioner obstetrician\u2010led maternity care in rural Western Australia"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9536-483X","authenticated-orcid":false,"given":"Carly","family":"Roxburgh","sequence":"first","affiliation":[{"name":"Rural Clinical School of Western Australia University of Western Australia Albany WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Moore","sequence":"additional","affiliation":[{"name":"Rural Clinical School of Western Australia University of Western Australia Busselton WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"McCulloch","sequence":"additional","affiliation":[{"name":"Rural Clinical School of Western Australia University of Western Australia Bunbury WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Valli","sequence":"additional","affiliation":[{"name":"Rural Clinical School of Western Australia University of Western Australia Bunbury WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danika","family":"Zuidersma","sequence":"additional","affiliation":[{"name":"Rural Clinical School of Western Australia University of Western Australia Bunbury WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri","family":"Pikora","sequence":"additional","affiliation":[{"name":"Rural Clinical School of Western Australia University of Western Australia Albany WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanh","family":"Ngo","sequence":"additional","affiliation":[{"name":"Rural Clinical School of Western Australia University of Western Australia Perth WA 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Together, this group of disorders constitutes a major cause of young-onset dementia. One of the three clinical variants of FTD is progressive nonfluent aphasia (PNFA), which is focused on in this study. The steroid hormone progesterone (PROG) is known to have an important role as a neurosteroid with potent neuroprotective and promyelination properties. In a case-control study of serum samples (39 FTD, 91 controls), low serum PROG was associated with FTD overall. In subgroup analysis, low PROG levels were significantly associated with FTD-MND and CBS, but not with PSP or PNFA. PROG levels of &gt;195 pg\/ml were significantly correlated with lower disease severity (frontotemporal dementia rating scale) for individuals with CBS. In the human neuroblastoma SK-N-MC cell line, exogenous PROG (9300-93,000 pg\/ml) had a significant effect on overall Tau and nuclear TDP-43 levels, reducing total Tau levels by ~1.5-fold and increasing nuclear TDP-43 by 1.7- to 2.0-fold. Finally, elevation of plasma PROG to a mean concentration of 5870 pg\/ml in an Ala315Thr (A315T) TARDBP transgenic mouse model significantly reduced the rate of loss of locomotor control in PROG-treated, compared with placebo, mice. The PROG treatment did not significantly increase survival of the mice, which might be due to the limitation of the transgenic mouse to accurately model TDP-43-mediated neurodegeneration. Together, our clinical, cellular and animal data provide strong evidence that PROG could be a valid therapy for specific related disorders of FTD.<\/jats:p>","DOI":"10.1242\/dmm.011460","type":"journal-article","created":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T02:51:34Z","timestamp":1371783094000},"source":"Crossref","is-referenced-by-count":9,"title":["Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levelsin vitro<\/i>and treatment of the A315TTARDBP<\/i>mouse model"],"prefix":"10.1242","author":[{"given":"Theresa N. 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Physiology"],"link":[{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/15\/s2\/article-p209-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/15\/s2\/article-p209-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/15\/s2\/article-p209-s.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T01:52:14Z","timestamp":1779414734000},"score":7.575938,"resource":{"primary":{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/15\/s2\/article-p209-s.xml"}},"issued":{"date-parts":[[2026,4]]},"references-count":0,"journal-issue":{"issue":"s2"},"URL":"https:\/\/doi.org\/10.31189\/2165-7629-15-s2.209","ISSN":["2165-7629","2165-6193"],"issn-type":[{"value":"2165-7629","type":"electronic"},{"value":"2165-6193","type":"print"}],"published":{"date-parts":[[2026,4]]}},{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:46:21Z","timestamp":1787237181716,"version":"build-2736575974"},"reference-count":25,"publisher":"American Geophysical Union (AGU)","issue":"1","license":[{"start":{"date-parts":[[2004,1,28]],"date-time":"2004-01-28T00:00:00Z","timestamp":1075248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Global Biogeochemical Cycles"],"published-print":{"date-parts":[[2004,3]]},"abstract":"Defining background concentrations for heavy metals in soils is essential for recognizing and managing soil pollution. However, background concentrations of metals in soils can vary naturally by several orders of magnitude. Moreover, many soils have also been subject to unquantifiable anthropogenic inputs of metals, in some cases, for centuries. Hence determination of heavy metal background concentrations in soils has to date been fraught with difficulty. Here we demonstrate that there are associations between the background heavy metal and Fe or Mn contents in soils which appear to be consistent for seven important heavy metals of environmental concern. The relationships are remarkably independent of both soil type and climatic setting. These observations provide the basis for a series of general equations from which it is proposed Southeast Asian including Australian, and possibly worldwide background concentrations for As, Cr, Co, Cu, Ni, Pb, and Zn in soils can be derived.<\/jats:p>","DOI":"10.1029\/2003gb002063","type":"journal-article","created":{"date-parts":[[2004,1,27]],"date-time":"2004-01-27T14:02:49Z","timestamp":1075212169000},"source":"Crossref","is-referenced-by-count":61,"title":["Geochemical indices allow estimation of heavy metal background concentrations in soils"],"prefix":"10.1029","volume":"18","author":[{"given":"R. E.","family":"Hamon","sequence":"first","affiliation":[{"name":"CSIRO Land and Water Glen Osmond, South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"CSIRO Land and Water Glen Osmond, South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Gilkes","sequence":"additional","affiliation":[{"name":"School of Earth and Geographical Sciences University of Western Australia Nedlands, Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. W.","family":"Rate","sequence":"additional","affiliation":[{"name":"School of Earth and Geographical Sciences University of Western Australia Nedlands, Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Zarcinas","sequence":"additional","affiliation":[{"name":"CSIRO Land and Water Glen Osmond, South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Robertson","sequence":"additional","affiliation":[{"name":"School of Earth and Geographical Sciences University of Western Australia Nedlands, Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Cozens","sequence":"additional","affiliation":[{"name":"CSIRO Land and Water Glen Osmond, South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Radford","sequence":"additional","affiliation":[{"name":"Newmont Australia West Perth, Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bettenay","sequence":"additional","affiliation":[{"name":"Barrick Gold of Australia Ltd. Perth, Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"13","published-online":{"date-parts":[[2004,1,28]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Baize D.(1997) Iron as a pedo\u2010geochemical indicator for determining the local background and assessing low\u2010level contamination of soils paper presented at4th Int. Conf. Int. Conf. on the Biogeochem. of Trace Elements Berkeley Calif."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005066327712"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2134\/jeq1999.00472425002800040018x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0375-6742(97)00020-4"},{"key":"e_1_2_5_6_1","unstructured":"Darnley A. G. et al. (1995) A global geochemical database for environmental and resource management: recommendations for international geochemical mapping Sci. Rep. 19 U. N. Educ. Sci. and Cult. Org. Paris."},{"key":"e_1_2_5_7_1","unstructured":"E. Epstein 2003"},{"key":"e_1_2_5_8_1","unstructured":"J. E. Fergusson 1991 Pergamon New York"},{"key":"e_1_2_5_9_1","first-page":"1","article-title":"Exploration geochemistry: Design and interpretation of soil surveys","volume":"3","author":"Fletcher W. K.","year":"1986","journal-title":"Rev. Econ. Geol."},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2136\/sssabookser5.1.2ed.c15"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/jr9370000655"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005001131472"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/es991309p"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2134\/jeq1993.00472425002200020015x"},{"key":"e_1_2_5_15_1","first-page":"61","volume-title":"The Biogeochemistry of Trace Metals","author":"Kabata\u2010Pendias A.","year":"1992"},{"key":"e_1_2_5_16_1","unstructured":"T. M. Lexmond T. Edelman 1992 Samson Alphen ann de Rijn Netherlands"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-8847-0_1"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1071\/SR99128"},{"key":"e_1_2_5_19_1","unstructured":"National Environment Protection Council(1999) National Environment Protection (Assessment of Site Contamination) Measure report Adelaide South Aust. Australia."},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/333134a0"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-7061(99)00090-7"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002540050229"},{"key":"e_1_2_5_23_1","unstructured":"G. E. Rayment F. R. Higginson 1992"},{"key":"e_1_2_5_24_1","unstructured":"A. W. Rose H. E. Hawkes J. S. Webb 1979 Academic San Diego Calif"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00103629609369636"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0269-7491(01)00104-X"}],"container-title":["Global Biogeochemical Cycles"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1029%2F2003GB002063","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agupubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1029\/2003GB002063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T20:27:14Z","timestamp":1697142434000},"score":7.5759196,"resource":{"primary":{"URL":"https:\/\/agupubs.onlinelibrary.wiley.com\/doi\/10.1029\/2003GB002063"}},"issued":{"date-parts":[[2004,1,28]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["10.1029\/2003GB002063"],"URL":"https:\/\/doi.org\/10.1029\/2003gb002063","archive":["Portico"],"ISSN":["0886-6236","1944-9224"],"issn-type":[{"value":"0886-6236","type":"print"},{"value":"1944-9224","type":"electronic"}],"published":{"date-parts":[[2004,1,28]]},"article-number":"2003GB002063"},{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:57:40Z","timestamp":1777568260219,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008812","name":"Defence Science and Technology Group","doi-asserted-by":"publisher","award":["MyIP 9277"],"award-info":[{"award-number":["MyIP 9277"]}],"id":[{"id":"10.13039\/501100008812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cognitive Engineering and Decision Making"],"published-print":{"date-parts":[[2024,6]]},"abstract":"Advances in opto-electronics enable replacement of conventional submarine periscopes which display only a portion of the horizon (low field of view), with digital periscopes, which can potentially display a 360\u00b0 panoramic digital representation of the horizon (high field of view). Digital periscopes can also provide digitized analysis tools for vessel (contact) range and course estimates. The current research compared the impact of a digital representation of a conventional periscope view with an alternative digital periscope prototype that displayed a larger (360\u00b0) field of view and provided digital analysis tools, on performance, perceived workload and system usability. Two experiments were conducted in a simulated submarine control room environment. In Experiment 1, the high field of view periscope yielded faster contact detection times, with no cost to the perceived workload or usability associated with the task of contact detection. In Experiment 2, the digitized analysis tools supported more accurate contact course and range estimates and lowered perceived workload, with no impact on perceived usability. These outcomes indicate that digitally augmenting the periscope is a technological innovation that can potentially facilitate submariner tasks, and highlight the benefits of applying knowledge from perceptual and cognitive science to the design of future digital periscope prototypes.<\/jats:p>","DOI":"10.1177\/15553434241235770","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T18:25:15Z","timestamp":1709576715000},"page":"114-136","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Augmenting Human Cognition With a Digital Submarine Periscope"],"prefix":"10.1177","volume":"18","author":[{"given":"Stephanie","family":"Michailovs","sequence":"first","affiliation":[{"name":"The University of Western Australia, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Irons","sequence":"additional","affiliation":[{"name":"Defence Science and Technology Group, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zach","family":"Howard","sequence":"additional","affiliation":[{"name":"The University of Western Australia, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Pond","sequence":"additional","affiliation":[{"name":"The University of Western Australia, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Defence Science and Technology Group, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Stoker","sequence":"additional","affiliation":[{"name":"Ergonomie, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troy","family":"Visser","sequence":"additional","affiliation":[{"name":"The University of Western Australia, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Bell","sequence":"additional","affiliation":[{"name":"The University of Western Australia, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Pinniger","sequence":"additional","affiliation":[{"name":"The University of Western Australia, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madison","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"The University of Western Australia, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Huf","sequence":"additional","affiliation":[{"name":"Defence Science and Technology Group, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen","family":"Carter","sequence":"additional","affiliation":[{"name":"The University of Western Australia, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayne","family":"Loft","sequence":"additional","affiliation":[{"name":"The University of Western Australia, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"bibr1-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1080\/00140139.2016.1216171"},{"key":"bibr2-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2012.11.003"},{"key":"bibr3-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1167\/15.2.18"},{"key":"bibr4-15553434241235770","unstructured":"Bonsor K. 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How photonics masts will work. https:\/\/science.howstuffworks.com\/photonic-mast1.htm (accessed Jan 2023)."},{"key":"bibr5-15553434241235770","doi-asserted-by":"publisher","DOI":"10.3390\/s21227624"},{"key":"bibr6-15553434241235770","first-page":"189","volume-title":"Usability evaluation in industry","author":"Brooke J.","year":"1996"},{"key":"bibr7-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.10.002"},{"key":"bibr8-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1177\/0018720814535628"},{"key":"bibr9-15553434241235770","doi-asserted-by":"publisher","DOI":"10.3758\/BF03212327"},{"key":"bibr10-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1016\/j.apergo.2013.07.008"},{"key":"bibr11-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.96.3.433"},{"key":"bibr12-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1117\/12.783814"},{"key":"bibr13-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1167\/11.5.14"},{"key":"bibr14-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-7421(08)60480-6"},{"key":"bibr15-15553434241235770","doi-asserted-by":"publisher","DOI":"10.3758\/BF03203267"},{"key":"bibr16-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149794"},{"key":"bibr17-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogpsych.2005.08.002"},{"key":"bibr18-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1117\/1.OE.52.4.041106"},{"key":"bibr19-15553434241235770","volume-title":"Human performance in the maritime control room: Using simulation for exploring team cognition and information layer design [Paper presentation]","author":"Irons J.","year":"2019"},{"key":"bibr20-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1037\/xhp0000156"},{"key":"bibr21-15553434241235770","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v088.i02"},{"key":"bibr22-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1016\/j.apergo.2023.104125"},{"key":"bibr23-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1177\/00187208211045872"},{"key":"bibr24-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1177\/0018720814541145"},{"key":"bibr25-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1177\/0018720813501549"},{"key":"bibr26-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1177\/0018720810376055"},{"key":"bibr60-15553434241235770","first-page":"531","volume-title":"Attention and Performance X: Control of Language Processes, Erlbaum, Hillsdale","author":"Posner M. I.","year":"1984"},{"key":"bibr28-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1038\/373066a0"},{"key":"bibr29-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1167\/7.2.3"},{"key":"bibr30-15553434241235770","volume-title":"It's a circular argument: Examining how a novel configuration impacts information flow in submarine control rooms","volume":"97","author":"Roberts A. P. J.","year":"2021"},{"key":"bibr31-15553434241235770","unstructured":"Royal Navy News. (2017). Glasgow firm celebrate century of providing periscopes to the Royal Navy. https:\/\/www.royalnavy.mod.uk\/news-and-latest-activity\/news\/2017\/september\/01\/170901-glasgow-firm-celebrate-century-of-providing-periscopes-to-the-royal-navy (Accessed Jan 2023)."},{"key":"bibr32-15553434241235770","volume-title":"Paper presented at the 10th Industrial and Organisational Psychology Conference","author":"Schmitt M. 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E.","year":"1997"},{"key":"bibr37-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1016\/0010-0285(80)90005-5"},{"key":"bibr38-15553434241235770","doi-asserted-by":"publisher","DOI":"10.3758\/s13423-018-1443-8"},{"key":"bibr39-15553434241235770","doi-asserted-by":"publisher","DOI":"10.3758\/s13423-017-1343-3"},{"key":"bibr40-15553434241235770","doi-asserted-by":"publisher","DOI":"10.3758\/s13423-017-1323-7"},{"key":"bibr41-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1117\/3.391324"},{"key":"bibr42-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1080\/00031305.2016.1154108"},{"key":"bibr43-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.02.005"},{"key":"bibr44-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1177\/154193128302700203"},{"key":"bibr45-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(02)00024-4"},{"key":"bibr46-15553434241235770","doi-asserted-by":"publisher","DOI":"10.3758\/s13423-020-01859-9"},{"key":"bibr47-15553434241235770","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1411"}],"container-title":["Journal of Cognitive Engineering and Decision Making"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15553434241235770","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15553434241235770","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15553434241235770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:59:58Z","timestamp":1777402798000},"score":7.575774,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15553434241235770"}},"issued":{"date-parts":[[2024,3,4]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/15553434241235770"],"URL":"https:\/\/doi.org\/10.1177\/15553434241235770","ISSN":["1555-3434"],"issn-type":[{"value":"1555-3434","type":"print"}],"published":{"date-parts":[[2024,3,4]]}},{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:34:55Z","timestamp":1777109695526,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Australian National Health and Medical Research Council","award":["35607"],"award-info":[{"award-number":["35607"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Objectives<\/jats:title>Malignant mesothelioma (MM) is a rare and generally fatal cancer, usually caused by asbestos, although about 5\u201310% of cases report no asbestos exposure. This study aimed to identify sources whereby people in Western Australia (WA) may be unknowingly exposed to asbestos or to other exposures which may cause MM.<\/jats:p><\/jats:sec>Methods<\/jats:title>Cases with no known asbestos exposure were selected from the WA Mesothelioma Register (WAMR). Matched controls were selected from hospital patients admitted for conditions unrelated to asbestos. Occupational histories were coded by an industrial hygienist. Data were analyzed using conditional logistic regression.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010eight MM participants and 134 controls were recruited. Risk of MM was increased (OR\u2009=\u20093.1, 95%CI 1.0\u20139.6) after no known, but likely, exposure to asbestos at work.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Because of its extensive use, few people in WA have never been exposed to asbestos. Unrecognized exposure may cause most MM cases initially regarded as \u201cno exposure.\u201d Am. J. Ind. Med. 60:432\u2013436, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.22695","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T11:18:54Z","timestamp":1488280734000},"page":"432-436","source":"Crossref","is-referenced-by-count":7,"title":["Risk factors for malignant mesothelioma in people with no known exposure to asbestos"],"prefix":"10.1002","volume":"60","author":[{"given":"Bill","family":"Musk","sequence":"first","affiliation":[{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"},{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Len","family":"Gordon","sequence":"additional","affiliation":[{"name":"Caltex Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helman","family":"Alfonso","sequence":"additional","affiliation":[{"name":"School of Public Health Curtin University Bentley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Reid","sequence":"additional","affiliation":[{"name":"School of Public Health Curtin University Bentley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nola","family":"Olsen","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Mina","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Franklin","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Peters","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fraser","family":"Brims","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennie","family":"Hui","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9223-0767","authenticated-orcid":false,"given":"Nicholas","family":"de Klerk","sequence":"additional","affiliation":[{"name":"School of Population Health University of Western Australia Perth Western Australia Australia"},{"name":"Telethon Kids Institute University of Western Australia Subiaco Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,28]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"AMR (Australian Mesothelioma Registry).2015. Australian Mesothelioma Registry 3rd annual report: Mesothelioma in Australia 2014. Canberra: Safe Work Australia."},{"key":"e_1_2_12_3_1","first-page":"5","article-title":"Mortality in miners and millers of crocidolite in Western Australia","volume":"45","author":"Armstrong BK","year":"1988","journal-title":"Br J Ind Med"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1984.tb132709.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.33.2.181"},{"key":"e_1_2_12_6_1","unstructured":"BriceSJ.1992. Regions with potential for asbestiform mineral occurrence Western Australia. Geological Survey of Western Australia Cartographic Services Branch Dept. of Minerals and Energy East Perth."},{"key":"e_1_2_12_7_1","first-page":"339","volume-title":"Mesothelioma","author":"de Klerk NH","year":"2002"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71109-X"},{"key":"e_1_2_12_9_1","first-page":"133","article-title":"Simian virus 40","volume":"104","year":"2013","journal-title":"International Agency for Research on Cancer (Monographs)"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009616"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203744"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.10047"},{"key":"e_1_2_12_13_1","first-page":"55","volume-title":"Mesothelioma","author":"Leigh J","year":"2002"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700210512"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.10125"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840901)54:5<951::AID-CNCR2820540536>3.0.CO;2-A"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1982.15"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-204161"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0274(200103)39:3<262::AID-AJIM1014>3.0.CO;2-R"},{"key":"e_1_2_12_20_1","first-page":"75","article-title":"Assay of pulmonary asbestos body and asbestos fibre burden in mesothelioma and other conditions in Western Australia","volume":"17","author":"Williams VM","year":"1996","journal-title":"Aust J Med Sci"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-008-0067-z"}],"container-title":["American Journal of Industrial Medicine"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajim.22695","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.22695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T20:59:21Z","timestamp":1696539561000},"score":7.5755157,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.22695"}},"issued":{"date-parts":[[2017,2,28]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/ajim.22695"],"URL":"https:\/\/doi.org\/10.1002\/ajim.22695","archive":["Portico"],"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"published":{"date-parts":[[2017,2,28]]}},{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:16:31Z","timestamp":1787897791152,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1086530"],"award-info":[{"award-number":["1086530"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2025,6]]},"abstract":"Background<\/jats:title>Assisted reproductive technology (ART) pregnancies are at greater risk of birth defects than non\u2010ART pregnancies. Teratogenic medication exposure is a potential cause of birth defects that has not been compared between ART and non\u2010ART pregnancies.<\/jats:p><\/jats:sec>Aims<\/jats:title>To determine whether the prevalence of exposure to teratogenic medicines during pregnancy varies by conception method (ART and three non\u2010ART groups: ovulation induction (OI), subfertile untreated, and fertile naturally conceiving).<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>We linked state and commonwealth datasets for all live and stillbirths (\u226520\u2009weeks) in Western Australia with a conception date \u22651 July 2012 and date of birth \u226431 December 2014. We calculated the prevalence of exposure to teratogenic medicines (Therapeutic Goods Association Category D\/X) across conception groups for the: (i) first trimester, and (ii) second and third trimesters.<\/jats:p><\/jats:sec>Results<\/jats:title>We identified 2041 ART, 590 OI, 2063 subfertile and 52\u2009987 fertile pregnancies (57\u2009681). The overall prevalence of exposure to Category D\/X medicines was 0.8% in the first trimester, and 0.7% in the second and third trimesters. Category X medicines exposure was <0.5% for all conception groups and trimesters. The first trimesters of ART and OI pregnancies were more often exposed to Category D medicines than subfertile and fertile pregnancies, (ART\u2009=\u20094.9%, OI\u2009=\u20092.0% vs subfertile\u2009=\u20091.3%, fertile\u2009=\u20090.6%) as were later trimesters (ART\u2009=\u20093.4%, OI\u2009=\u20091.4% vs subfertile\u2009=\u20090.9%, fertile\u2009=\u20090.6%).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The overall prevalence of exposure to teratogenic medicines is low; however, exposure was greatest in pregnancies arising from ART and may be a modest contributing factor to the higher rate of birth defects observed among ART babies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajo.13911","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T06:13:53Z","timestamp":1733724833000},"page":"390-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Are assisted reproductive technology pregnancies more likely to be exposed to teratogenic medication? A whole\u2010population study"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0018-962X","authenticated-orcid":false,"given":"Anna","family":"Kemp\u2010Casey","sequence":"first","affiliation":[{"name":"Quality Use of Medicines and Pharmacy Research Centre University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-3040","authenticated-orcid":false,"given":"Roger","family":"Hart","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynaecology, Medical School The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Milne","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1138-2756","authenticated-orcid":false,"given":"Carol","family":"Bower","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0729-4737","authenticated-orcid":false,"given":"Melanie L.","family":"Walls","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynaecology The University of Western Australia Perth Western Australia Australia"},{"name":"Concept Fertility Centre Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9583-3683","authenticated-orcid":false,"given":"John L.","family":"Yovich","sequence":"additional","affiliation":[{"name":"PIVET Medical Centre Perth Western Australia Australia"},{"name":"School of Pharmacy and Biomedical Sciences, Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Burton","sequence":"additional","affiliation":[{"name":"Concept Fertility Centre Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6276-7010","authenticated-orcid":false,"given":"Yanhe","family":"Liu","sequence":"additional","affiliation":[{"name":"Fertility North Perth Western Australia Australia"},{"name":"School of Human Sciences, The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4513-8102","authenticated-orcid":false,"given":"Hamish","family":"Barblett","sequence":"additional","affiliation":[{"name":"Genea Hollywood Fertility Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6817-2031","authenticated-orcid":false,"given":"Michele","family":"Hansen","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute Perth Western Australia Australia"},{"name":"Centre for Child Health Research The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.07.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa272"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1556745"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.04.138"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2024.1378224"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.02.027"},{"issue":"2","key":"e_1_2_6_10_1","first-page":"92","article-title":"Hypertensive disorders in pregnant women receiving fertility treatments","volume":"12","author":"Barekat M","year":"2018","journal-title":"Int J Fertil Steril"},{"key":"e_1_2_6_11_1","unstructured":"Therapeutic Goods Administration (TGA).Australian product information \u2013 Provera\u00ae (medroxyprogesterone acetate) tablets 2024. [Accessed 2 May 2024.] Available from URL:https:\/\/www.ebs.tga.gov.au\/ebs\/picmi\/picmirepository.nsf\/pdf?OpenAgent&id=CP\u20102010\u2010PI\u201005386\u20103&d=20240502172310101."},{"key":"e_1_2_6_12_1","unstructured":"Therapeutic Goods Administration (TGA).Prescribing medicines in pregnancy database 2024. [Accessed 7 March 2024.] Available from URL:https:\/\/www.tga.gov.au\/prescribing\u2010medicines\u2010pregnancy\u2010database#more."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1705"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.13044"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5845"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.17061\/phrp2541546"},{"key":"e_1_2_6_17_1","unstructured":"KempA PaigeE BanksE.Beginner's guide to using Pharmaceutical Benefits Scheme data: tips and pitfalls 2012. [Accessed 7 March 2024.] Available from URL:https:\/\/nceph.anu.edu.au\/files\/Guide_to_Using_PBS_Data_20131125_0.pdf."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-021-02111-6"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.10.028"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010024\u201003060\u20106"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2252-4"},{"key":"e_1_2_6_22_1","volume-title":"Socio\u2010Economic Indexes for Areas (SEIFA) \u2013 Technical Paper","author":"Pink B","year":"2006"},{"key":"e_1_2_6_23_1","unstructured":"Norwegian Institute of Public Health.Guidelines for ATC classification and DDD assignment 2024. [Accessed 7 March 2024.] Available from URL:https:\/\/atcddd.fhi.no\/atc_ddd_index_and_guidelines\/guidelines\/."},{"key":"e_1_2_6_24_1","first-page":"2021","article-title":"Hollywood pharmacy owner David gibbon Mavin Brewster jailed over $40,000 IVF fraud","volume":"1","author":"Hampton S","year":"2021","journal-title":"West Austral"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-21014-9"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2020.03.008"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2014.018"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.13071"},{"key":"e_1_2_6_29_1","unstructured":"Australian Government Department of Health and Aged Care.Pharmaceutical benefits scheme IVF medicines: frequently asked questions: new arrangements from 1 July 2015.2016. [Accessed 11 April 2024.] Available from URL:https:\/\/www.pbs.gov.au\/files\/ivf\u2010medicines\u2010files\/revised\u2010faqs\u2010ivf\u2010medicines\u201025\u2010june\u20102015.pdf."},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12621"}],"container-title":["Australian and New Zealand Journal of Obstetrics and Gynaecology"],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajo.13911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T11:27:11Z","timestamp":1753183631000},"score":7.5755157,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/ajo.13911"}},"issued":{"date-parts":[[2024,12,9]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/ajo.13911"],"URL":"https:\/\/doi.org\/10.1111\/ajo.13911","archive":["Portico"],"ISSN":["0004-8666","1479-828X"],"issn-type":[{"value":"0004-8666","type":"print"},{"value":"1479-828X","type":"electronic"}],"published":{"date-parts":[[2024,12,9]]},"assertion":[{"value":"2024-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:44:16Z","timestamp":1777463056193,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:00:00Z","timestamp":1570579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Australian Postgraduate Award"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["British Journal of Occupational Therapy"],"published-print":{"date-parts":[[2020,7]]},"abstract":"\n Introduction<\/jats:title>\n Early career occupational therapists experience considerable learning. This research sought to develop a theory of how they learn once practising.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n The research employed a constructivist grounded theory methodology. Interviews were conducted with 20 participants who were either experienced ( n\u2009=\u20098), early career occupational therapists ( n\u2009=\u200910) or in supporting roles for early career occupational therapists ( n\u2009=\u20092). Participants were asked their views about what early career occupational therapists find troublesome and how they respond. Data were collected and analysed concurrently. Open, focused and theoretical coding were used to develop a theory.<\/jats:p>\n <\/jats:sec>\n \n Findings<\/jats:title>\n The theory of learning-to-practise occupational therapy included four learning thresholds: consolidating professional reasoning; navigating into the workplace; building competence and confidence; and developing a personal theory and practise style. There were 11 strategies identified that early career occupational therapists use to cross the learning thresholds. Early career occupational therapists\u2019 understanding and value of knowledge shifted, which culminated in them \u2018realising\u2019 their personal theory and practice style. They refined their values and beliefs and learned to be more deliberate and reflective in their thinking and actions.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Early career occupational therapists were challenged, which promoted learning. This research extends understanding of the learning needs, thinking and actions taken by early career occupational therapists to cross learning thresholds and to develop their personal theory and practice style.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/0308022619876842","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T01:21:02Z","timestamp":1570670462000},"page":"469-482","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Learning thresholds for early career occupational therapists: A grounded theory of learning-to-practise"],"prefix":"10.1177","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4471-0509","authenticated-orcid":false,"given":"Carolyn M","family":"Murray","sequence":"first","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Edwards","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Jones","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merrill","family":"Turpin","sequence":"additional","affiliation":[{"name":"The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,10,9]]},"reference":[{"key":"bibr1-0308022619876842","doi-asserted-by":"publisher","DOI":"10.1080\/13562517.2016.1248390"},{"key":"bibr2-0308022619876842","doi-asserted-by":"publisher","DOI":"10.1007\/s10459-017-9773-2"},{"key":"bibr3-0308022619876842","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1630.2006.00545.x"},{"key":"bibr4-0308022619876842","doi-asserted-by":"publisher","DOI":"10.1177\/030802260506800605"},{"key":"bibr5-0308022619876842","first-page":"131","volume-title":"The Handbook of Transformative Learning: Theory, Research and Practice","author":"Brookfield S","year":"2012"},{"key":"bibr6-0308022619876842","volume-title":"Constructing Grounded Theory","author":"Charmaz K","year":"2014"},{"key":"bibr7-0308022619876842","volume-title":"Contemporary Issues in Occupational Therapy: Reasoning and Reflection","author":"Creek J","year":"2007"},{"key":"bibr8-0308022619876842","first-page":"91","volume-title":"Practice Knowledge and Expertise in the Health Professions","author":"Cusick A","year":"2001"},{"key":"bibr9-0308022619876842","doi-asserted-by":"publisher","DOI":"10.3109\/11038128.2015.1082623"},{"key":"bibr10-0308022619876842","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-6209-128-3_9"},{"key":"bibr11-0308022619876842","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1630.12165"},{"key":"bibr12-0308022619876842","first-page":"295","volume-title":"Clinical Reasoning: Forms of Inquiry in a Therapeutic Practice","author":"Fleming H","year":"1994"},{"key":"bibr13-0308022619876842","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1630.12144"},{"key":"bibr14-0308022619876842","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1630.12010"},{"key":"bibr15-0308022619876842","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1630.2012.01029.x"},{"key":"bibr16-0308022619876842","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-32958-1_13"},{"key":"bibr17-0308022619876842","first-page":"35","volume-title":"Willard and Spackman\u2019s Occupational Therapy","author":"Hooper B","year":"2014","edition":"12"},{"key":"bibr18-0308022619876842","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1630.2007.00726.x"},{"key":"bibr19-0308022619876842","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1584.2003.00476.x"},{"key":"bibr20-0308022619876842","volume-title":"Qualitative Research Methods","author":"Liamputtong P","year":"2013"},{"key":"bibr21-0308022619876842","first-page":"412","volume-title":"Improving Student Learning: Theory and Practice \u2013 10 Years On","author":"Meyer J","year":"2003"},{"key":"bibr22-0308022619876842","doi-asserted-by":"publisher","DOI":"10.1163\/9789460912078"},{"key":"bibr23-0308022619876842","first-page":"57","volume-title":"The Handbook of Transformative Learning: Theory, Research and Practice","author":"Mezirow J","year":"2012"},{"key":"bibr24-0308022619876842","doi-asserted-by":"publisher","DOI":"10.4276\/030802209X12577616538753"},{"key":"bibr25-0308022619876842","unstructured":"Murray C (2016)\n Responses to troublesome aspects of knowledge and practice: A grounded theory of learning-to-practice occupational therapy\n . 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Located in the Harts Range, central Australia, it is characterized by the development of a domal structure including two sub\u2010domes separated by a steeply dipping median high\u2010strain zone. Dominantly, orthogneiss basement crops out through a structurally overlying cover sequence represented by the Harts Range Group and records evidence of hydration, recrystallization, and partial melting of precursor Paleoproterozoic granulite facies assemblages at amphibolite facies conditions. The structurally lowest parts of the Harts Range Group were metamorphosed to peak conditions of 10.5\u00a0kbar and ~880\u00b0C during rift\u2010related magmatism at 480\u2013460\u2009Ma, immediately prior to the onset of the Alice Springs Orogeny at 450\u2013300\u2009Ma. By contrast, the underlying Entia Gneiss Complex records widespread metamorphism and wet melting at upper amphibolite facies conditions. Phase equilibrium modelling and in situ LA\u2013ICP\u2013MS geochronology of rare, low\u2010variance kyanite\u2013garnet\u2010bearing metapelites indicate that maximum P\u2013T<\/jats:italic> conditions of ~9\u00a0kbar and ~680\u00b0C were reached between c<\/jats:italic>. 360\u2013330\u2009Ma, demonstrating a distinctive metamorphic and temporal evolution relative to the overlying Harts Range Group that can be linked to rheological stratification. Based on the integration of our results with existing monazite, zircon, and titanite geochronology, we interpret doming of the Entia Gneiss Complex to have involved compressive ascent of rheologically weakened crust below a region of extending upper crust near the termination of the Alice Springs Orogeny. In this way, the Harts Range Group represents a cooled, locally extending thrust sheet over ductile basement quasi\u2010concurrent with doming. Texturally\u2010late sillimanite combined with increasing Y content in monazite indicates high\u2010temperature, kyanite\u2010grade metamorphism was closely followed by decompression (3\u20134\u00a0kbar drop from peak conditions) and rapid cooling below 600\u00b0C during emplacement of the Entia Gneiss Complex at shallower crustal levels. The findings of this study highlight the feedback between hydration, retrogression, rheological weakening, and strain accommodation, thus allowing better evaluation of the thermomechanical history of gneiss dome formation within a narrow (<80\u2009km wide) preconditioned intracontinental corridor.<\/jats:p><\/jats:sec>Highlights<\/jats:title>\n\nFirst modern P\u2013T\u2013t<\/jats:italic> framework for gneiss dome formation in the Entia Gneiss Complex, central Australia.<\/jats:p><\/jats:list-item>\nThe onset of metamorphism, partial melting and ductile flow at c<\/jats:italic>. 360\u2009Ma was catalysed by hydration of granulite facies basement during rift inversion.<\/jats:p><\/jats:list-item>\nRapid exhumation of partially molten crust from depths of >20\u2009km is marked by fluid\u2010mediated resetting of monazite down to c<\/jats:italic>. 310\u2009Ma.<\/jats:p><\/jats:list-item>\nRheological stratification enabled and accelerated exhumation of the highest\u2010grade corridor of a narrow intracontinental orogen.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/jmg.12635","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T16:57:24Z","timestamp":1631465844000},"page":"457-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pressure\u2013temperature\u2013time constraints on gneiss dome formation in an intracontinental orogen"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5763-9679","authenticated-orcid":false,"given":"Jan","family":"Varga","sequence":"first","affiliation":[{"name":"UniSA STEM University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Raimondo","sequence":"additional","affiliation":[{"name":"UniSA STEM University of South Australia Adelaide South Australia Australia"},{"name":"Future Industries Institute University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Morrissey","sequence":"additional","affiliation":[{"name":"Future Industries Institute University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Kelsey","sequence":"additional","affiliation":[{"name":"Department of Earth Sciences University of Adelaide Adelaide South Australia Australia"},{"name":"Geological Survey of Western Australia East Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hand","sequence":"additional","affiliation":[{"name":"Department of Earth Sciences University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-9268(94)00061-U"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1029\/2000TC001190"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1314.2000.00289.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/petrology\/37.3.521"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-7037(98)00292-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1144\/GSL.SP.2006.268.01.05"},{"key":"e_1_2_10_8_1","unstructured":"Bendall B.(2000).Mid\u2010Palaeozoic shear zones in the Strangways Range: A record of intracratonic tectonism in the Arunta Inlier central Australia. 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While bracing and surgical interventions are established treatments for moderate to severe curves, non-operative approaches such as physiotherapeutic scoliosis-specific exercises (PSSE) play an increasingly pivotal role, particularly for mild to moderate curve magnitudes. ScoliBalance\u00ae is a specific PSSE program that incorporates active self-correction, postural training, and stabilization exercises.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVE:<\/jats:title>\n To investigate the effects of the ScoliBalance\u00ae PSSE program on AIS patients as a sole treatment intervention and assessed the impact on Cobb angle, the gold standard radiographic measure, as well as the angle of trunk rotation (ATR) aiming to provide further evidence on its role in the non-surgical management of this condition.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n A consecutive cohort of 12 patients (11 F, 1 M, mean age 14.9 \u00b1 1.9 y) with mild to moderate scoliosis (mean Cobb angle 21.7 \u00b1 7.1\u00b0; mean ATR: 6.5 \u00b1 2.9\u00b0) were treated using only PSSE. Patients received an individualized ScoliBalance\u00ae program based on PSSE principles that combine physical therapy, chiropractic, and exercise rehabilitation. The program focuses on achieving a specific postural correction for the patient's curve type and strengthening it with specific exercises adapted from various PSSE schools. Patients initially received their program in one-hour, one-on-one weekly sessions with a trained ScoliBalance\u00ae provider. Patients performed exercises and progressions for 15\u201320 minutes daily at home. Patients were treated for an average of 34.25 \u00b1 23.5 months.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n Using only the ScoliBalance\u00ae PSSE treatment protocol, all patients experienced curve reduction or stabilization in Cobb angle and ATR measures. The average improvement in Cobb angle was -2.4 \u00b1 3.1\u00b0, a statistically significant reduction (t(11) = 2.7, p = 0.011, Cohen\u2019s d = 0.78), where the final average Cobb angle measured 19.25 \u00b1 8.3\u00b0. Considering a change in Cobb angle is regarded as \u2265 5\u00b0, 3 out of 12 patients experienced curve reduction (25%), whilst the remaining 9 patients stabilized (75%); no patients experienced curve regression (0%). The average improvement in ATR was -1.25 \u00b1 1.4\u00b0 and was also statistically significant (t(11) = 3.2, p = 0.004, Cohen\u2019s d = 0.92). Considering a valid change in ATR is \u2265 2\u00b0, 4 of 12 patients experienced ATR improvement (33.3%) whilst the remaining 8 stabilized (66.6%); no patients experienced worsening of the ATR.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n ScoliBalance\u00ae PSSE, as a sole intervention for mild-to-moderate AIS demonstrated stabilization or reduction in Cobb angle and ATR in all 12 patients over an average of 34 months. This series offers preliminary evidence for the clinical application of ScoliBalance\u00ae PSSE as a viable treatment option for the non-surgical management of AIS patients with mild to moderate curve magnitudes.<\/jats:p>\n <\/jats:sec>","DOI":"10.31189\/2165-7629-15-s2.256","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:59:20Z","timestamp":1777341560000},"page":"256","source":"Crossref","is-referenced-by-count":0,"title":["A CASE SERIES INVESTIGATING THE EFFECTS ON COBB ANGLE IN ADOLESCENT IDIOPATHIC SCOLIOSIS USING THE SCOLIBALANCE\u00ae PHYSIOTHERAPEUTIC SCOLIOSIS-SPECIFIC EXERCISE PROTOCOL"],"prefix":"10.31189","volume":"15","author":[{"given":"Rosemary","family":"Mirenzi","sequence":"first","affiliation":[{"name":"ScoliCare Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Oakley","sequence":"additional","affiliation":[{"name":"ScoliCare Australia, Sydney, 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Abstracts"],"language":"en","deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T20:03:36Z","timestamp":1784923416000},"score":7.574875,"resource":{"primary":{"URL":"https:\/\/www.earthdoc.org\/content\/journals\/10.63929\/22020586.2024.1.064"}},"issued":{"date-parts":[[2024,10,3]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,10,3]]}},"URL":"https:\/\/doi.org\/10.63929\/22020586.2024.1.064","ISSN":["2202-0586"],"issn-type":[{"value":"2202-0586","type":"print"}],"published":{"date-parts":[[2024,10,3]]}},{"indexed":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T06:40:08Z","timestamp":1745304008245,"version":"3.40.4"},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"8_Supplement_1","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,4,21]]},"abstract":"Abstract<\/jats:title>\n The introns of the gene encoding the long noncoding RNA (lncRNA) GAS5 host up to 10 C\/D box small nucleolar RNAs (snoRNAs). However, whether there is a regulatory and functional relationship between these snoRNAs and GAS5 is unknown. Here, we show that the expression of SNORD80, but not the other snoRNAs, parallels GAS5 expression and is regulated alongside GAS5 in response to cellular stress. The 2\u2032-O-methylation at the A496 site, located within a segment of GAS5 complementing the conserved RNA binding region on SNORD80, promotes GAS5 stability and consequent upregulation. This methylation requires SNORD80, as it is diminished by knockdown of SNORD80 and increased by SNORD80 overexpression, similar to the effects of manipulating the expression of fibrillarin, the methyltransferase of the box C\/D small nucleolar ribonucleoprotein particle (snoRNP). The upregulation of SNORD80 in response to cellular stress is due to an enhancement in its stability, which is associated with an increase in its interaction with fibrillarin. Collectively, these results identify a novel role for SNORD80 in guiding 2\u2032-O-methylation to stabilize GAS5. This uncovers a feedforward regulatory loop at the GAS5 gene locus in response to cellular stress and sheds new light on posttranscriptional mechanisms governing lncRNA expression.<\/jats:p>\n \n Citation Format:<\/jats:title>\n Liang Xu, Xiao hong Zhao, Yuan yuan Zhang, Lei Jin, Xu Dong Zhang. SNORD80-guided 2'-O-methylation stabilizes the lncRNA GAS5 to regulate cellular stress responses. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 2799.<\/jats:p>\n <\/jats:sec>","DOI":"10.1158\/1538-7445.am2025-2799","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T12:43:12Z","timestamp":1745239392000},"page":"2799-2799","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 2799: SNORD80-guided 2'-O-methylation stabilizes the lncRNA GAS5 to regulate cellular stress responses"],"prefix":"10.1158","volume":"85","author":[{"given":"Liang","family":"Xu","sequence":"first","affiliation":[{"name":"University of Newcastle, Australia, Newcastle, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao hong","family":"Zhao","sequence":"additional","affiliation":[{"name":"University of Newcastle, Australia, Newcastle, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Newcastle, Australia, Newcastle, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[{"name":"University of Newcastle, Australia, Newcastle, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Newcastle, Australia, Newcastle, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/85\/8_Supplement_1\/2799\/756498\/Abstract-2799-SNORD80-guided-2-O-methylation","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/85\/8_Supplement_1\/2799\/756498\/Abstract-2799-SNORD80-guided-2-O-methylation","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T06:16:15Z","timestamp":1745302575000},"score":7.574808,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/85\/8_Supplement_1\/2799\/756498\/Abstract-2799-SNORD80-guided-2-O-methylation"}},"issued":{"date-parts":[[2025,4,21]]},"references-count":0,"journal-issue":{"issue":"8_Supplement_1","published-print":{"date-parts":[[2025,4,21]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2025-2799","ISSN":["0008-5472","1538-7445"],"issn-type":[{"type":"print","value":"0008-5472"},{"type":"electronic","value":"1538-7445"}],"published":{"date-parts":[[2025,4,21]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:58:39Z","timestamp":1753880319362,"version":"3.41.2"},"reference-count":0,"publisher":"American Society of Mechanical Engineers","content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,6,17]]},"abstract":"The effect of bow flare angle on greenwater overtopping is numerically investigated using CFD with a VOF surface capturing scheme. A two dimensional fixed rectangular box with a flare angle is adopted to represent a Floating, Production, Storage and Offloading Unit (FPSO) with flare. Deep water conditions are assumed. The incident waves are focused wave groups based on the New Wave formulation, which represents the most probable free surface elevation around a large crest and includes much of the spectral properties of the underlying random sea state. Bow flare angles of 10, 30 and 50 degrees are analysed, which cover the typical range of a FPSO unit. For the box model, the length L, draft D and freeboard f are modelled as L\/D = 15 and f\/D = 0.25, which are typical dimensions for a FPSO. A range of wave steepness and relative length are considered, which lead to a variety of overtopping conditions including the hammer fist (HF), plunging plus dam break (PDB) and dam break (DB) greenwater events observed for vessels with no bow flare angle. The numerical simulations are performed using the open source CFD toolbox OpenFOAM of version 2.4.0 together with a fully nonlinear wave generation and absorption utility waves2Foam. The effect of the bow flare angle is quantified by analyzing changes in freeboard exceedance, overtopping volume and horizontal momentum flux of water on deck flow for different bow flare angles. The results indicate that, for the special case in which the vessel is fixed, the bow flare angle can significantly reduce each of these quantities. It is also shown that trends in the overtopping volume and momentum flux can be explained reasonably well using the modified dam break model proposed by Zhang et al. [14].<\/jats:p>","DOI":"10.1115\/omae2018-77487","type":"proceedings-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T08:31:13Z","timestamp":1537864273000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":3,"title":["Numerical Investigation of Effects of Bow Flare Angle on Greenwater Overtopping a Fixed Offshore Vessel"],"prefix":"10.1115","author":[{"given":"Xiantao","family":"Zhang","sequence":"first","affiliation":[{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Draper","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Wolgamot","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhua","family":"Zhao","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33","published-online":{"date-parts":[[2018,9,25]]},"event":{"name":"ASME 2018 37th International Conference on Ocean, Offshore and Arctic Engineering","start":{"date-parts":[[2018,6,17]]},"sponsor":["Ocean, Offshore and Arctic Engineering Division"],"location":"Madrid, Spain","end":{"date-parts":[[2018,6,22]]},"acronym":"OMAE2018"},"container-title":["Volume 1: Offshore Technology"],"link":[{"URL":"http:\/\/asmedigitalcollection.asme.org\/OMAE\/proceedings-pdf\/doi\/10.1115\/OMAE2018-77487\/2534712\/v001t01a002-omae2018-77487.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T18:46:07Z","timestamp":1567449967000},"score":7.574808,"resource":{"primary":{"URL":"https:\/\/asmedigitalcollection.asme.org\/OMAE\/proceedings\/OMAE2018\/51203\/Madrid,%20Spain\/277858"}},"issued":{"date-parts":[[2018,6,17]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1115\/omae2018-77487","published":{"date-parts":[[2018,6,17]]},"article-number":"V001T01A002"},{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:08:16Z","timestamp":1773234496090,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1111\/ceo.12865","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T08:45:38Z","timestamp":1476953138000},"page":"304-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Audible clicking on blinking: an adverse effect of topical prostaglandin analogue medication"],"prefix":"10.1111","volume":"45","author":[{"given":"Farshad","family":"Abedi","sequence":"first","affiliation":[{"name":"Flinders Medical Centre Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Chappell","sequence":"additional","affiliation":[{"name":"Flinders Medical Centre Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie E","family":"Craig","sequence":"additional","affiliation":[{"name":"Flinders Medical Centre Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,21]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2008.08.012"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569521003796860"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2009.0019"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12163"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12725"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e3182231202"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X12455659"}],"container-title":["Clinical & Experimental Ophthalmology"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.12865","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.12865","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.12865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:32:47Z","timestamp":1696303967000},"score":7.574734,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.12865"}},"issued":{"date-parts":[[2016,11,21]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/ceo.12865"],"URL":"https:\/\/doi.org\/10.1111\/ceo.12865","archive":["Portico"],"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"published":{"date-parts":[[2016,11,21]]},"assertion":[{"value":"2016-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:02:58Z","timestamp":1784167378573,"version":"3.55.0"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["CE200100025"],"award-info":[{"award-number":["CE200100025"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Prom J of Aust"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Issue Addressed<\/jats:title>\n \n Masculine norms influence men's health and wellbeing. In Australia, interest in the role of these masculine norms resulted in an assessment of masculine norm adherence being included in the\n Ten to Men<\/jats:italic>\n Study, measured using the 22\u2010item version of the Conformity to Masculine Norms Inventory (CMNI\u201022). The CMNI\u201022 has been previously treated as a unidimensional (i.e., single overall score) and multidimensional (i.e., 11\u2010factors) assessment. However, there remains limited evidence regarding the optimal way to use the CMNI\u201022 data provided by more than 14\u2009000 Australian men. Accordingly, this study aimed to (a) investigate the latent factor structure of the CMNI\u201022, and (b) to compare the utility of unidimensional and multidimensional approaches to predict men's wellbeing over time.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n Factor analyses revealed that the CMNI\u201022 is best understood as a multidimensional measure containing 11 factors. These dimensions often report better internal reliability than the total score. The multidimensional conceptualisation also explains larger proportions of variance in a range of mental health outcomes (e.g., depression, anxiety, psychological wellbeing) compared to the unidimensional one, highlighting different associations between specific dimensions and mental health outcomes.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Scholars and policymakers utilising the\n Ten to Men<\/jats:italic>\n dataset (or the CMNI\u201022) to understand links between masculinity and men's health will benefit from using this multidimensional conceptualisation instead of the unidimensional alternative. So What? When more comprehensive screening assessments are not possible, the CMNI\u201022 appears to provide a brief, but reliable, multidimensional assessment of masculine norms. It is not advisable to use a single total score.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hpja.70192","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:36:11Z","timestamp":1777271771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Masculine Norm Adherence Among Australian Men: Latent Structure of the\n CMNI\u201022<\/scp>\n and Its Links With Mental Health Outcomes"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-8104","authenticated-orcid":false,"given":"Vincent O.","family":"Mancini","sequence":"first","affiliation":[{"name":"The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5022-9925","authenticated-orcid":false,"given":"Jack","family":"Brett","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2814-7114","authenticated-orcid":false,"given":"Jasleen","family":"Chhabra","sequence":"additional","affiliation":[{"name":"Orygen Melbourne Victoria Australia"},{"name":"Centre for Youth Mental Health The University of Melbourne Melbourne Victoria Australia"},{"name":"Movember Foundation Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3438-7461","authenticated-orcid":false,"given":"James","family":"Clarke","sequence":"additional","affiliation":[{"name":"School of Population Health Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6972-2875","authenticated-orcid":false,"given":"Thomas P.","family":"Nevill","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1060-2024","authenticated-orcid":false,"given":"David A.","family":"Preece","sequence":"additional","affiliation":[{"name":"School of Population Health Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6854-1554","authenticated-orcid":false,"given":"Zac","family":"Seidler","sequence":"additional","affiliation":[{"name":"Orygen Melbourne Victoria Australia"},{"name":"Centre for Youth Mental Health The University of Melbourne Melbourne Victoria Australia"},{"name":"Movember Foundation Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0274-5466","authenticated-orcid":false,"given":"Bradley","family":"Roberts","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Western Australia Australia"},{"name":"Perron Institute for Neurological and Translational Science Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Martin","sequence":"additional","affiliation":[{"name":"Australian Institute of Family Studies (AIFS) Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,26]]},"reference":[{"key":"e_1_2_15_2_1","first-page":"80","volume-title":"Meta\u2010Analyses of the Relationship Between Conformity to Masculine Norms and Mental Health\u2010Related Outcomes","author":"Wong Y. 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To address this, we propose the Zero Inflation Diffusion Framework (ZIDF), which integrates Gaussian perturbation for smoothing zero-inflated distributions, Transformer-based prediction for capturing temporal patterns, and diffusion-based denoising to restore the original data structure. In our experiments, we use observational precipitation data collected from South Australia along with synthetically generated zero-inflated data. Results show that ZIDF demonstrates significant performance improvements over multiple state-of-the-art precipitation forecasting models, achieving up to 56.7% reduction in MSE and 21.1% reduction in MAE relative to the baseline Non-stationary Transformer. These findings highlight ZIDF\u2019s ability to robustly handle sparse time series data and suggest its potential generalizability to other domains where zero inflation is a key challenge.<\/jats:p>","DOI":"10.3233\/faia250921","type":"book-chapter","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:46:05Z","timestamp":1761126365000},"source":"Crossref","is-referenced-by-count":1,"title":["From Noise to Precision: A Diffusion-Driven Approach to Zero-Inflated Precipitation Prediction"],"prefix":"10.3233","author":[{"given":"Wentao","family":"Gao","sequence":"first","affiliation":[{"name":"University of South Australia, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuyong","family":"Li","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuc Duy","family":"Le","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongren","family":"Chen","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Du","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixue","family":"Liu","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchang","family":"Zhao","sequence":"additional","affiliation":[{"name":"CSIRO Data61, Canberra, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"CSIRO Environment, Canberra, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7437","container-title":["Frontiers in Artificial Intelligence and Applications","ECAI 2025"],"link":[{"URL":"https:\/\/ebooks.iospress.nl\/pdf\/doi\/10.3233\/FAIA250921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:46:05Z","timestamp":1761126365000},"score":7.5736356,"resource":{"primary":{"URL":"https:\/\/ebooks.iospress.nl\/doi\/10.3233\/FAIA250921"}},"issued":{"date-parts":[[2025,10,21]]},"ISBN":["9781643686318"],"references-count":0,"URL":"https:\/\/doi.org\/10.3233\/faia250921","ISSN":["0922-6389","1879-8314"],"issn-type":[{"value":"0922-6389","type":"print"},{"value":"1879-8314","type":"electronic"}],"published":{"date-parts":[[2025,10,21]]}},{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T12:40:51Z","timestamp":1759927251474,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"S18","license":[{"start":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T00:00:00Z","timestamp":1703462400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2023,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Cognitive reserve (CR) is thought to be protective against late\u2010life cognitive decline induced by neurodegenerative disease and other forms of neurological insult. Although CR is thought to be influenced by early life experiences, information about its development during childhood and adolescence is lacking. The current study operationalised CR with a residual index approach (Reed et al., 2010) optimised for a diverse paediatric cohort. Criterion and construct validity of the index was also assessed.<\/jats:p><\/jats:sec>Method<\/jats:title>Data collected across 2011\u20102019 from N<\/jats:italic> = 115 children (MAge<\/jats:sub><\/jats:italic>= 10.48, SDAge<\/jats:sub><\/jats:italic>= 0.61, n = 72 [63%] male, n<\/jats:italic> = 43 [37%] with ADHD) were acquired from the Murdoch Children\u2019s Research Institute. Elastic\u2010net regularised linear regression was used to generate baseline and longitudinal CR indices that represented residual variance in (change in) fluid intellect (Matrix Reasoning) not explained by demographics (i.e., sex and age) or MRI\u2010based brain variables (i.e., cortical surface areas and cerebellar\/subcortical volumes); brain regions were selected with the aim of partialling maximal variance out of the CR residual index. Outcome variables, including word reading, math computation, and Conners 3 ADHD Index were then regressed onto baseline and longitudinal CR indices.<\/jats:p><\/jats:sec>Results<\/jats:title>Baseline CR predicted baseline math computation (p<\/jats:italic><.001), while change in CR predicted change in word reading ability (p<\/jats:italic><.001). Further, in individuals with low grey matter volume, higher CR was associated with higher word reading score (p<\/jats:italic> = .019) and lower ADHD Index (p<\/jats:italic> = .047) compared to those with lower CR, at baseline. Higher change in CR also protected word reading trajectory in individuals with higher change in WMH volumes (p<\/jats:italic> = .048).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These results suggest that individual differences in CR, as operationalised through a residual index, may be detectable in school\u2010age children. While findings regarding criterion and construct validity of the CR index are stronger than previous research featuring an unoptimised residual model (Irani, 2022), support for the validity of the index remains incomplete compared to established geriatric models \u2013 possibly due in part to a relatively less predictable relationship between brain structure and cognition in children versus adults. Future research would benefit from longer\u2010term follow\u2010up in paediatric samples with greater variability in neuropathological indices, cognitive functioning, academic achievement, and functional outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.078876","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T08:42:35Z","timestamp":1703493755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Developing a residual cognitive reserve index in a paediatric cohort with ADHD"],"prefix":"10.1002","volume":"19","author":[{"given":"Zubin","family":"Irani","sequence":"first","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Sheridan","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicki","family":"Anderson","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC Australia"},{"name":"Royal Children\u2019s Hospital, Parkville, VIC Australia"},{"name":"University of Melbourne, Parkville, VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J","family":"Silk","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC Australia"},{"name":"Deakin University, Melbourne, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Weinborn","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon E","family":"Gavett","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,25]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.078876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:58:44Z","timestamp":1759924724000},"score":7.573616,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.078876"}},"issued":{"date-parts":[[2023,12]]},"references-count":0,"journal-issue":{"issue":"S18","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/alz.078876"],"URL":"https:\/\/doi.org\/10.1002\/alz.078876","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"type":"print","value":"1552-5260"},{"type":"electronic","value":"1552-5279"}],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-12-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e078876"},{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:16:16Z","timestamp":1778717776909,"version":"3.51.4"},"reference-count":2,"publisher":"CSIRO Publishing","issue":"S1","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2026,5,14]]},"abstract":"The Kipper gas field, located in Australia\u2019s offshore Gippsland Basin, has and will continue to play an increasingly important role in the Gippsland Basin supply mix, where 100% of gas from the basin is sold into Australia\u2019s east coast domestic market. Production commenced in 2017 with two subsea wells, completed in the upper reservoir sands only, as part of the initial development phase. A significant capacity enhancement project followed in 2024 with the installation of Kipper Compression. In 2025, the Kipper Unit Joint Venture participants executed the second phase of the Kipper Field subsurface development plan, drilling the KPA-A3 well into the pressure depleted Golden Beach reservoirs to increase field rate and develop the uncompleted lower sands, with the well location sufficiently spaced from existing wells. A key objective of the well program was to obtain pressures in all sands to confirm reservoir connectivity through likely fault juxtaposition. As the KPA-A3 well plays a crucial role in sustaining Kipper gas production until the end of field life, protection from aquifer and reliable long-life production were key objectives for the well. This work outlines the reasoning behind the selection of the crestal target, presents the reservoir characterisation prognosis and outcome and demonstrates how pressure data has informed the dynamic uncertainties of the field. The Kipper Field is Operated by Esso Australia Resources Pty Ltd (32.5%), with co-venturers Woodside Energy (Bass Strait) Pty Ltd (32.5%) and MEPAU A Pty Ltd (35%).<\/jats:p>","DOI":"10.1071\/ep25217","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:01:02Z","timestamp":1778716862000},"source":"Crossref","is-referenced-by-count":0,"title":["Advancing subsurface development in the Kipper Gas Field: reservoir connectivity, pressure data integration, and strategic well placement in the Gippsland Basin"],"prefix":"10.1071","volume":"66","author":[{"given":"Steven","family":"Spencer","sequence":"first","affiliation":[{"name":"AEsso Australia Pty Ltd, Melbourne, Vic, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Boyle","sequence":"additional","affiliation":[{"name":"AEsso Australia Pty Ltd, Melbourne, Vic, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Ryan","sequence":"additional","affiliation":[{"name":"AEsso Australia Pty Ltd, Melbourne, Vic, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvo","family":"Nagel","sequence":"additional","affiliation":[{"name":"AEsso Australia Pty Ltd, Melbourne, Vic, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Robertson","sequence":"additional","affiliation":[{"name":"AEsso Australia Pty Ltd, Melbourne, Vic, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afif","family":"Jais","sequence":"additional","affiliation":[{"name":"AEsso Australia Pty Ltd, Melbourne, Vic, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izaz-ul","family":"Haque","sequence":"additional","affiliation":[{"name":"AEsso Australia Pty Ltd, Melbourne, Vic, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"2026051320005928200_R1","doi-asserted-by":"publisher","DOI":"10.1071\/EP24239","article-title":"Multi-disciplined\/collaborative team approach to deliver Kipper Compression Project.","volume":"65","author":"Fuller","year":"2025","journal-title":"Australian Energy Producers Journal"},{"key":"2026051320005928200_R2","doi-asserted-by":"publisher","DOI":"10.1071\/EP24154","article-title":"Maximising deliverability of the Kipper Field to ensure reliable supply of gas into the east coast Australia market.","volume":"65","author":"Spencer","year":"2025","journal-title":"Australian Energy Producers Journal"}],"container-title":["Australian Energy Producers Journal"],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/doi\/10.1071\/EP25217\/1867336\/ep25217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/doi\/10.1071\/EP25217\/1867336\/ep25217.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:01:02Z","timestamp":1778716862000},"score":7.57348,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/ep\/article\/66\/S1\/EP25217\/272117\/Advancing-subsurface-development-in-the-Kipper-Gas"}},"issued":{"date-parts":[[2026,5,14]]},"references-count":2,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2026,5,14]]}},"URL":"https:\/\/doi.org\/10.1071\/ep25217","ISSN":["2982-0308"],"issn-type":[{"value":"2982-0308","type":"electronic"}],"published":{"date-parts":[[2026,5,14]]},"article-number":"EP25217"},{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T01:31:04Z","timestamp":1788658264514,"version":"build-2803163510"},"reference-count":82,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Proprioception is a vital aspect of motor control and when degraded or lost can have a profound impact on function in diverse clinical populations. This systematic review aimed to identify clinically related tools to measure proprioceptive acuity, to classify the construct(s) underpinning the tools, and to report on the clinimetric properties of the tools. We searched key databases with the pertinent search terms, and from an initial list of 935 articles, we identified 57 of relevance. These articles described 32 different tools or methods to quantify proprioception. There was wide variation in methods, the joints able to be tested, and the populations sampled. The predominant construct was active or passive joint position detection, followed by passive motion detection and motion direction discrimination. The clinimetric properties were mostly poorly evaluated or reported. The Rivermead Assessment of Somatosensory Perception was generally considered to be a valid and reliable tool but with low precision; other tools with higher precision are potentially not clinically feasible. Clinicians and clinical researchers can use the summary tables to make more informed decisions about which tool to use to match their predominant requirements. Further discussion and research is needed to produce measures of proprioception that have improved validity and utility.<\/jats:p>","DOI":"10.1177\/1545968315573055","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T08:23:42Z","timestamp":1424939022000},"page":"933-949","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":313,"title":["Assessing Proprioception"],"prefix":"10.1177","volume":"29","author":[{"given":"Susan","family":"Hillier","sequence":"first","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Immink","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, 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and Neural Repair"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1545968315573055","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1545968315573055","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1545968315573055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:06:04Z","timestamp":1777705564000},"score":7.5734377,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1545968315573055"}},"subtitle":["A Systematic Review of Possibilities"],"issued":{"date-parts":[[2015,2,23]]},"references-count":82,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1177\/1545968315573055"],"URL":"https:\/\/doi.org\/10.1177\/1545968315573055","ISSN":["1545-9683","1552-6844"],"issn-type":[{"value":"1545-9683","type":"print"},{"value":"1552-6844","type":"electronic"}],"published":{"date-parts":[[2015,2,23]]}},{"indexed":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T06:13:22Z","timestamp":1651212802170},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4S","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.juro.2017.02.518","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T18:50:32Z","timestamp":1491245432000},"source":"Crossref","is-referenced-by-count":0,"title":["MP16-12 SELECTIVE INTERNAL RADIATION THERAPY (SIRT) WITH YTTRIUM-90 (Y-90) RESIN MICROSPHERES IN PATIENTS WITH PRIMARY RENAL CELL CARCINOMA (RCC): IMPACT ON RENAL FUNCTION AND QUALITY OF LIFE IN THE RESIRT STUDY"],"prefix":"10.1097","volume":"197","author":[{"given":"Peter","family":"Aslan","sequence":"first","affiliation":[{"name":"Hurstville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Clark","sequence":"additional","affiliation":[{"name":"Korgarah, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Patel","sequence":"additional","affiliation":[{"name":"Westmead, 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&amp; Dementia"],"published-print":{"date-parts":[[2020,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Enhancing quality of life (QoL) is the primary goal of aged care services for older people with dementia. Despite this, there are no culturally appropriate QoL measures for older Indigenous peoples with or without dementia. This study aims to address this gap.<\/jats:p><\/jats:sec>Method<\/jats:title>The Good Spirit, Good Life (GSGL) tool was co\u2010developed with older Aboriginal Australians and services in Perth and Melbourne, Australia. Adaptations were made following face validity with Aboriginal participants with dementia or cognitive impairment. Quantitative data collected by Aboriginal researchers included demographic information, GSGL tool (12 items, total score 60), KICA Cog (Indigenous cognitive assessment), EQ\u20105D\u20105L (health\u2010related QoL tool), ICECAP\u2010O (generic wellbeing tool for older people), Geriatric Anxiety Inventory\u2010Short Form (GAI\u2010SF), KICA\u2010Dep (Indigenous depression scale), Aboriginal Resilience and Recovery Questionnaire (ARRQ\u201025), and GSGL Carers version.<\/jats:p><\/jats:sec>Result<\/jats:title>120 Aboriginal people aged 45\u201086 years participated in the GSGL validity study, 68% were women. The mean total GSGL score was 48.7\/60. 11% of participants had cognitive impairment or dementia. GSGL internal (Spearman\u2010Brown 0.83, Cronbach\u2019s alpha 0.75) and inter\u2010rater (ICC 0.69\u20100.95) reliability was strong. Concurrent validity is supported by strong correlation with ICECAP\u2010O (Spearman\u2019s Rho (\u03c1)=0.61, p<0.05). GSGL was weakly correlated with health\u2010related EQ\u20105D\u20105L (\u03c1=\u20100.32, p<0.05). Known\u2010groups validity was supported by significant difference in GSGL scores between participants with (40%) and without anxiety (Student\u2019s t test t=4.3, p<0.05) and with (44%) and without depression (t=4.1, p<0.05). GSGL scores did not differ significantly for participants with and without cognitive impairment. Following multivariate regression, resilience (\u03b2=0.55, 95%CI [0.39, 0.70]) and GAI\u2010SF score (\u03b2=\u20100.22, [\u20100.38, \u20100.06]) were associated with total GSGL score. There was significant difference in GSGL item scores (p<0.05; Hotelling\u2019s T2<\/jats:sup> test), with the \u2018Country\u2019 item having the lowest mean score (3.05\/5, p<0.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The GSGL is a culturally valid tool for measuring quality of life in older Aboriginal Australians. Items are based on the quality of life priorities of Aboriginal Australians with and without dementia. Interventions targeted at building resilience and treating anxiety and depression may improve the quality of life of older Aboriginal Australians. More could be done by services and families to facilitate older people\u2019s connection to Country.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.040108","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T14:02:19Z","timestamp":1607349739000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The validity of the good spirit, good quality\u2010of\u2010life tool for older Aboriginal Australians"],"prefix":"10.1002","volume":"16","author":[{"given":"Lianne","family":"Gilchrist","sequence":"first","affiliation":[{"name":"The University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Bessarab","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Douglas","sequence":"additional","affiliation":[{"name":"University of Melbourne Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"LoGiudice","sequence":"additional","affiliation":[{"name":"The University of Melbourne Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Ratcliffe","sequence":"additional","affiliation":[{"name":"The University of South Australia Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Flicker","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Hyde","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Smith","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,7]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.040108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.040108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:17:23Z","timestamp":1759879043000},"score":7.573306,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.040108"}},"subtitle":["Development and validation of cognitive and quality of life assessments for older indigenous peoples internationally"],"issued":{"date-parts":[[2020,12]]},"references-count":0,"journal-issue":{"issue":"S7","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/alz.040108"],"URL":"https:\/\/doi.org\/10.1002\/alz.040108","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"type":"print","value":"1552-5260"},{"type":"electronic","value":"1552-5279"}],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"2020-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e040108"},{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:51:00Z","timestamp":1778143860728,"version":"3.51.4"},"reference-count":13,"publisher":"BMJ","issue":"18","funder":[{"DOI":"10.13039\/100031198","name":"Department of Health, Government of Western Australia","doi-asserted-by":"publisher","award":["EMHS Research Registrar Fellowship"],"award-info":[{"award-number":["EMHS Research Registrar Fellowship"]}],"id":[{"id":"10.13039\/100031198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031198","name":"Department of Health, Government of Western Australia","doi-asserted-by":"publisher","award":["Research Translation Project Grant"],"award-info":[{"award-number":["Research Translation Project Grant"]}],"id":[{"id":"10.13039\/100031198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2025,6,7]]},"published-print":{"date-parts":[[2025,9]]},"abstract":"\n Background<\/jats:title>\n A pathway incorporating an option for early discharge based on a single low level of high-sensitivity cardiac troponin I (hs-cTnI) at presentation increases the proportion of patients presenting with a potential acute coronary syndrome (ACS) that can be discharged directly from the emergency department (ED), reducing length of stay without any increase in adverse events at 30 days. Here, we report the 1-year outcomes of patients managed using this pathway.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We recruited two cohorts of patients with a potential ACS, without high-risk features. The \u2018standard\u2019 cohort was managed according to the Australian national guidelines and the Single Troponin Accelerated Triage (\u2018STAT\u2019) cohort was managed using the study pathway. 12-month outcomes were assessed using linked administrative data.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Between May 2018 and October 2019, we recruited 2255 patients (1131 standard vs 1124 STAT), mean age 55 years, 53% male. 709 (63%) patients managed using the STAT pathway were discharged directly from ED, compared with 403 (38%) patients using the standard pathway, with a 47\u2009min reduction in median hospital length of stay. At 12 months, there were no significant differences in unadjusted all-cause death (STAT 0.62% vs standard 0.97%, p=0.35) or myocardial infarction (MI) (STAT 0.62% vs standard 1.24%, p=0.13).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n A clinical pathway which incorporates early discharge based on a single low serum hs-cTnI is associated with an increased proportion of patients with a potential ACS discharged directly from the ED and reduced length of stay, without an increase in death or MI at 1 year.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/heartjnl-2024-325188","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T13:25:24Z","timestamp":1751030724000},"page":"847-850","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Single high-sensitivity troponin levels to assess patients with potential acute coronary syndromes: 1-year outcomes"],"prefix":"10.1136","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8308-1592","authenticated-orcid":false,"given":"Cara","family":"Barnes","sequence":"first","affiliation":[{"name":"Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank M","family":"Sanfilippo","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-6905","authenticated-orcid":false,"given":"Daniel Michael","family":"Fatovich","sequence":"additional","affiliation":[{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Emergency Medicine, Royal Perth Hospital, Perth, Western Australia, Australia"},{"name":"Centre for Clinical Research in Emergency Medicine, Harry Perkins Institute of Medical Research, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Macdonald","sequence":"additional","affiliation":[{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Emergency Medicine, Royal Perth Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Alcock","sequence":"additional","affiliation":[{"name":"Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Spiro","sequence":"additional","affiliation":[{"name":"Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0847-4361","authenticated-orcid":false,"given":"Carl","family":"Schultz","sequence":"additional","affiliation":[{"name":"Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Briffa","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2417-4673","authenticated-orcid":false,"given":"Graham S","family":"Hillis","sequence":"additional","affiliation":[{"name":"Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"2025092003225232000_111.18.847.1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-317997"},{"key":"2025092003225232000_111.18.847.2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv320"},{"key":"2025092003225232000_111.18.847.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2016.06.789"},{"key":"2025092003225232000_111.18.847.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.10.080"},{"key":"2025092003225232000_111.18.847.5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017719"},{"key":"2025092003225232000_111.18.847.6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.052380"},{"key":"2025092003225232000_111.18.847.7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055009"},{"key":"2025092003225232000_111.18.847.8","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-316692"},{"key":"2025092003225232000_111.18.847.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.04.040"},{"key":"2025092003225232000_111.18.847.10","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad191"},{"key":"2025092003225232000_111.18.847.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30635-8"},{"key":"2025092003225232000_111.18.847.12","first-page":"200185","article-title":"Risk of early recurrence and mortality in high-risk myocardial infarction patients: A population-based linked data study","volume":"17","author":"Nedkoff","year":"2023","journal-title":"Int J Cardiol Cardiovasc Risk Prev"},{"key":"2025092003225232000_111.18.847.13","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-11-35"}],"container-title":["Heart"],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heartjnl-2024-325188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T10:22:57Z","timestamp":1758363777000},"score":7.573175,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heartjnl-2024-325188"}},"issued":{"date-parts":[[2025,6,27]]},"references-count":13,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2025,8,26]]},"published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1136\/heartjnl-2024-325188"],"URL":"https:\/\/doi.org\/10.1136\/heartjnl-2024-325188","ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"published":{"date-parts":[[2025,6,27]]}},{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:06:22Z","timestamp":1785369982404,"version":"3.55.0"},"reference-count":81,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T00:00:00Z","timestamp":1702080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Health Psychol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"\n Subjective well-being influences mental and physical health. Fortunately, interventions exist to improve people\u2019s subjective well-being. Emotion regulation and self-compassion are two transdiagnostic factors that impact mental health and have been separately shown to be associated with subjective well-being. However, their combined relationship with subjective well-being has not yet been examined. To address this gap, the current novel study aimed to determine if there is a combined relationship between self-compassion, emotion regulation, and dimensions of subjective well-being cross-sectionally in adults living in the United States. Participants ( n\u2009=\u2009559; 50% female; M\n age<\/jats:sub>\n \u2009=\u200957.70\u2009years) completed an online survey via Prime Panels from CloudResearch, capturing their responses on the interested constructs. Analyses showed that emotion regulation significantly mediated the relationships between self-compassion and various subjective well-being dimensions, specifically, positive affect ( d\u2009=\u20090.32), negative affect ( d\u2009=\u20091.17), and eudemonic well-being ( d\u2009=\u20090.79). Our findings have both clinical and research implications.\n <\/jats:p>","DOI":"10.1177\/13591053231209668","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T04:44:09Z","timestamp":1702097049000},"page":"863-876","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Does emotion regulation mediate the relationship between self-compassion and subjective well-being? A cross-sectional study of adults living in the United States"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5251-9321","authenticated-orcid":false,"given":"Stacey Michelle","family":"Ericson","sequence":"first","affiliation":[{"name":"Monash University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua Paul","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Monash University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia Josephine","family":"Federico","sequence":"additional","affiliation":[{"name":"Monash University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua James","family":"Fleming","sequence":"additional","affiliation":[{"name":"Monash University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Froggatt","sequence":"additional","affiliation":[{"name":"Monash University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Eleid","sequence":"additional","affiliation":[{"name":"Monash University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget Mary","family":"Finn","sequence":"additional","affiliation":[{"name":"Monash University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7141-2537","authenticated-orcid":false,"given":"Kim","family":"Johnston","sequence":"additional","affiliation":[{"name":"Monash University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru Ying","family":"Cai","sequence":"additional","affiliation":[{"name":"Monash University, Australia"},{"name":"Autism Spectrum Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,12,9]]},"reference":[{"key":"bibr1-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2009.11.004"},{"key":"bibr2-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1017\/sjp.2018.2"},{"key":"bibr3-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1007\/s10902-014-9587-3"},{"key":"bibr4-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2014.03.002"},{"key":"bibr5-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1037\/a0025754"},{"key":"bibr6-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1022-9_3"},{"key":"bibr7-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-119"},{"key":"bibr8-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-020-01498-0"},{"key":"bibr9-13591053231209668","doi-asserted-by":"publisher","DOI":"10.3109\/00048674.2010.529604"},{"key":"bibr10-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1037\/ocp0000023"},{"key":"bibr11-13591053231209668","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.693570"},{"key":"bibr12-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1177\/1362361318774558"},{"key":"bibr13-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1968"},{"key":"bibr14-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1002\/cpp.2372"},{"key":"bibr15-13591053231209668","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J","year":"1988","edition":"2"},{"key":"bibr16-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1002\/job.174"},{"key":"bibr17-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1111\/papt.12107"},{"key":"bibr18-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-2350-6_2"},{"key":"bibr19-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa4901_13"},{"key":"bibr20-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.54.101601.145056"},{"key":"bibr21-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-018-0307-6"},{"key":"bibr22-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1111\/aphw.12090"},{"key":"bibr23-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2004.00674.x"},{"key":"bibr24-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1007\/s10608-016-9772-2"},{"key":"bibr25-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-019-01134-6"},{"key":"bibr26-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133481"},{"key":"bibr27-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1037\/pspp0000157"},{"key":"bibr28-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1027\/1015-5759\/a000081"},{"key":"bibr29-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1007\/s10578-019-00867-8"},{"key":"bibr30-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1023\/B:JOBA.0000007455.08539.94"},{"key":"bibr31-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsp.2006.09.002"},{"key":"bibr32-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1080\/1047840X.2014.940781"},{"key":"bibr33-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.85.2.348"},{"key":"bibr34-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1037\/11468-001"},{"key":"bibr35-13591053231209668","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2018.00539"},{"key":"bibr36-13591053231209668","volume-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach","author":"Hayes AF","year":"2018","edition":"2"},{"key":"bibr37-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1037\/xap0000254"},{"key":"bibr38-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1007\/s10804-016-9227-8"},{"key":"bibr39-13591053231209668","doi-asserted-by":"publisher","DOI":"10.2466\/03.20.PR0.114k22w4"},{"key":"bibr40-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1007\/s11205-008-9346-0"},{"key":"bibr41-13591053231209668","doi-asserted-by":"publisher","DOI":"10.1111\/aphw.12127"},{"issue":"2","key":"bibr42-13591053231209668","first-page":"73","volume":"8","author":"Kabat-Zinn J","year":"2003","journal-title":"Constructivism in the Human Sciences"},{"key":"bibr43-13591053231209668","first-page":"3","volume-title":"Well-Being: The Foundations of Hedonic Psychology","author":"Kahneman 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P","year":"2011","journal-title":"SIS Journal of Projective Psychology & Mental 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of Health 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and Nerve"],"published-print":{"date-parts":[[2019,5]]},"abstract":"ABSTRACT<\/jats:title>Introduction<\/jats:italic>: Currently, our knowledge of standard data for muscle morphology in children is largely limited to the 1969 article by Brooke and Engel (BE). In 2016, we reported normal muscle morphology from vastus lateralis biopsies in ambulant children with cerebral palsy (CP). This report compares our normal biopsy results against BE standard value criteria. Methods<\/jats:italic>: Single\u2010blind prospective cross\u2010sectional study design. Results<\/jats:italic>: Results of biopsies taken in ambulant children with CP were normal according to morphometry and light and electron microscopy; however, only 5 of 10 fulfilled the BE standard value criteria. Discussion<\/jats:italic>: This short report highlights the requirement for contemporary age\u2010specific normative data from a larger number of biopsies, including typically developing children. Review of the literature suggests that biopsy material may be available from typically developing children who were control patients in research trials. This morphometric data could contribute to expanding the normative data set. Muscle Nerve<\/jats:italic> 59:590\u2013590, 2019<\/jats:p>","DOI":"10.1002\/mus.26426","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T08:10:22Z","timestamp":1548403822000},"page":"590-593","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Normative data of muscle fiber diameter of vastus lateralis during childhood: a field test"],"prefix":"10.1002","volume":"59","author":[{"given":"Jane","family":"Valentine","sequence":"first","affiliation":[{"name":"Department of Paediatric Rehabilitation Princess Margaret Hospital Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Dyke","sequence":"additional","affiliation":[{"name":"Neuropathology Section Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosyln","family":"Ward","sequence":"additional","affiliation":[{"name":"Faculty of Health Science Curtin University Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashleigh","family":"Thornton","sequence":"additional","affiliation":[{"name":"Department of Paediatric Rehabilitation Princess Margaret Hospital Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve","family":"Blair","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Stannage","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Princess Margaret Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Paediatric Rehabilitation Princess Margaret Hospital Perth Western Australia Australia"},{"name":"Faculty of Health Science Curtin University Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicki","family":"Fabian","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.19.6.591"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24763"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1997.tb07414.x"},{"key":"e_1_2_6_5_1","unstructured":"National Association of Testing Authorities of Australia. Available athttp:\/\/www.nata.com.au\/nata. Acessed January 29 2019."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6890-14-18"},{"key":"e_1_2_6_7_1","first-page":"74","article-title":"The WHO growth chart: historical considerations and current scientific issues","volume":"53","author":"Porrini M","year":"1996","journal-title":"BiBl Nutr Dieta"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12027"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-2-44"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24576"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2938"},{"issue":"4","key":"e_1_2_6_12_1","article-title":"Morphometric analyses of normal pediatric brachial biceps and quadriceps muscle tissue","volume":"28","author":"Sallum AME","year":"2013","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1978.tb15200.x"}],"container-title":["Muscle & Nerve"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.26426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.26426","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T17:46:05Z","timestamp":1694367965000},"score":7.572805,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.26426"}},"issued":{"date-parts":[[2019,2,14]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1002\/mus.26426"],"URL":"https:\/\/doi.org\/10.1002\/mus.26426","archive":["Portico"],"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"published":{"date-parts":[[2019,2,14]]},"assertion":[{"value":"2018-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:11:59Z","timestamp":1777677119992,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T00:00:00Z","timestamp":1350864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Health Promotion Practice"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Issue addressed. The Physical Activity and Nutrition Program for Seniors (PANS) program aimed to increase levels of physical activity and improve the diet of insufficiently active community-based seniors aged 60 to 70 years using a range of strategies. Comprehensive process evaluation was used to determine the suitability and appropriateness of the resources and effectiveness of the strategies. Method. Process evaluation data (qualitative and quantitative) were collected on the program strategies and resources throughout, and at the conclusion of the intervention period. Results. The program strategies\/resources were found to be relevant to the population, assisting participants to increase their level of physical activity and improve their diet. Participants reported that the program resources were suitable for their age-group (84%), encouraged them to think about physical activity (78%), and nutrition (70%). Participants reported that they used the pedometer (91%) and recorded daily steps (78%). Moreover, the provision of group guides facilitated individuals to set and achieve personal goals. Conclusion. The PANS strategies and resources were appropriate, which supported the seniors in identifying, establishing, and achieving their physical activity and nutrition goals. Minor refinements of the program were recommended based on the findings.<\/jats:p>","DOI":"10.1177\/1524839912461504","type":"journal-article","created":{"date-parts":[[2012,10,23]],"date-time":"2012-10-23T02:13:29Z","timestamp":1350958409000},"page":"543-551","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Physical Activity and Nutrition Program for Seniors (PANS)"],"prefix":"10.1177","volume":"14","author":[{"given":"Linda","family":"Burke","sequence":"first","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonine M.","family":"Jancey","sequence":"additional","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Howat","sequence":"additional","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andy H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Shilton","sequence":"additional","affiliation":[{"name":"Heart Foundation Australia (WA Branch), Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,22]]},"reference":[{"key":"bibr1-1524839912461504","volume-title":"Census of population and housing: Socio-economic indexes for areas (SEIFA) 2006","author":"Australian Bureau of Statistics","year":"2008"},{"key":"bibr2-1524839912461504","volume-title":"National Health Survey: Summary of results, 2007-2008","author":"Australian Bureau of Statistics","year":"2009"},{"key":"bibr3-1524839912461504","volume-title":"Social foundations of thought and action","author":"Bandura A.","year":"1986","edition":"3"},{"key":"bibr4-1524839912461504","volume-title":"Self-efficacy: The exercise of control","author":"Bandura A.","year":"1997"},{"key":"bibr5-1524839912461504","volume-title":"Choose health: Be Active: A physical activity guide for older Australians","author":"Brown W. J.","year":"2008","edition":"3"},{"issue":"77","key":"bibr6-1524839912461504","first-page":"1","volume":"1","author":"Burke L.","year":"2008","journal-title":"BMC Research Notes"},{"key":"bibr7-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-10-751"},{"key":"bibr8-1524839912461504","volume-title":"U.S. physical activity statistics: 2007 state demographic data comparison","author":"Centers for Disease Control and Prevention","year":"2007"},{"key":"bibr9-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(03)00381-X"},{"key":"bibr10-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2010.10.002"},{"key":"bibr11-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.2002.1134"},{"key":"bibr12-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000058"},{"key":"bibr13-1524839912461504","volume-title":"The Australian guide to healthy eating","author":"Department of Health and Ageing","year":"1998"},{"key":"bibr14-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2006.07.011"},{"key":"bibr15-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2010.34"},{"key":"bibr16-1524839912461504","volume-title":"Health behaviour and health education: Theory, research and practice","author":"Glanz K.","year":"2008","edition":"4"},{"key":"bibr17-1524839912461504","volume-title":"Health promotion planning: An educational and ecological approach","author":"Green L. W.","year":"2005","edition":"4"},{"key":"bibr18-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/48.3.378"},{"key":"bibr19-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1093\/her\/cyp017"},{"key":"bibr20-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/48.2.251"},{"key":"bibr21-1524839912461504","first-page":"152","volume":"15","author":"Jancey J.","year":"2007","journal-title":"Journal of Aging and Health"},{"key":"bibr22-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/786827"},{"key":"bibr23-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.643"},{"key":"bibr24-1524839912461504","volume-title":"Eat well for life: A practical guide to the dietary guidelines for older Australians","author":"National Health and Medical Research Council","year":"1999"},{"key":"bibr25-1524839912461504","volume-title":"Evaluation in a nutshell: A practical guide to the evaluation of health promotion programs","author":"Nutbeam D.","year":"2006"},{"key":"bibr26-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7538.413"},{"key":"bibr27-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.2.289"},{"key":"bibr28-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2009.11.009"},{"key":"bibr29-1524839912461504","doi-asserted-by":"publisher","DOI":"10.4337\/9781849808620"},{"key":"bibr30-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-8-17"},{"key":"bibr31-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-10-578"},{"key":"bibr32-1524839912461504","volume-title":"Making health communication programs work: A planner\u2019s guide","author":"U.S. Department of Health and Human Services","year":"1992"},{"key":"bibr33-1524839912461504","volume-title":"2008 Physical activity guidelines for Americans","author":"U.S. Department of Health and Human Services","year":"2008"},{"key":"bibr34-1524839912461504","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2009.00712.x"},{"key":"bibr35-1524839912461504","volume-title":"World health statistics 2012","author":"World Health Organization","year":"2012"}],"container-title":["Health Promotion Practice"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1524839912461504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1524839912461504","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1524839912461504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:22:52Z","timestamp":1777450972000},"score":7.572768,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1524839912461504"}},"subtitle":["Process Evaluation"],"issued":{"date-parts":[[2012,10,22]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1177\/1524839912461504"],"URL":"https:\/\/doi.org\/10.1177\/1524839912461504","ISSN":["1524-8399","1552-6372"],"issn-type":[{"value":"1524-8399","type":"print"},{"value":"1552-6372","type":"electronic"}],"published":{"date-parts":[[2012,10,22]]}},{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:09:54Z","timestamp":1787602194171,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:00:00Z","timestamp":1754092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:00:00Z","timestamp":1754092800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GTN2015902"],"award-info":[{"award-number":["GTN2015902"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n People with intellectual disability experience higher rates of physical and mental health problems than those without intellectual disability. Health literacy includes accessing, understanding, appraising and applying health information. Improving health literacy is associated with better health outcomes. The internet is a primary source of health information for many people. This study aimed to evaluate available online health resources for people with intellectual disability and their families to understand information gaps.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n A scoping review of grey literature was conducted using two searches: a targeted search of disability organisation websites and an advanced Google search using key terms. The methods were guided by a modified version of Arksey and O'Malley's methodological approach.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 1165 health resources for people with intellectual disability and their families were identified. Tests, checks and procedures were the most common category of health addressed (\n n<\/jats:italic>\n \u2009=\u2009227, 19.5%) and most content was directed at the individual with intellectual disability (\n n<\/jats:italic>\n \u2009=\u2009837, 71.9%). Resources addressed the health literacy domains of accessing (\n n<\/jats:italic>\n \u2009=\u20091165, 100%) and understanding (\n n<\/jats:italic>\n \u2009=\u20091132, 97.2%) information more often than appraising (\n n<\/jats:italic>\n \u2009=\u2009575, 49.5%) and applying (\n n<\/jats:italic>\n \u2009=\u2009415, 35.6%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Improving the health literacy of people with intellectual disability is an important part of addressing health disparities and requires understanding of the available information. Some information gaps were identified, including limited sexual health resources and mental health resources for adolescents.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jir.70028","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T10:39:25Z","timestamp":1754131165000},"page":"121-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Online Health Literacy Resources for People With Intellectual Disability: A Grey Literature Scoping Review"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9613-4713","authenticated-orcid":false,"given":"Jessica","family":"Keeley","sequence":"first","affiliation":[{"name":"The Kids Research Institute Australia The University of Western Australia Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenmei","family":"Yeap","sequence":"additional","affiliation":[{"name":"The Kids Research 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Fortunately the majority of colorectal cancer (CRC) cases are preventable by early detection and removal by colonoscopy or surgery. Currently in Australia, the only widely used non-invasive screening test for CRC is the immunological faecal occult blood test (iFOBT), which has been shown to reduce CRC incidence and mortality by 15-25% [2]. There are however significant issues that limit its effectiveness as a diagnostic screening tool, such as a poor positive predictive value of 5.3% for suspected cancer and low participation rate of approximately 33.5% in 2013, as seen in the Australian National Bowel Cancer Screening Program (NBCSP)[2]. Evidence indicates a robust, blood-based, diagnostic assay would increase screening participation and compliance. In our systematic analysis of 68 individual biomarkers using logistic regression strategies, we have identified a unique 3 protein biomarker panel blood test consisting of Insulin like growth factor binding protein 2 (IGFBP2), Dickkopf-3 (DKK3), and Pyruvate kinase M2(PKM2)[3]. This panel not only differentiates between CRC and normal patient sera with 95% specificity and 73% sensitivity in a single measurement (c.f. FOBT: 35-50 sensitivity [4]) but early stage disease. Currently, we are prospectively collecting a new cohort of over 1,000 blood samples from volunteers that have undergone colonoscopy, that include CRC patients, controls and other pathologies (IBD, other cancers) to specifically determine the performance of this blood test in asymptomatic and surveillance screening populations. We will also evaluate directly the accuracy and performance of our biomarker panel, as a diagnostic test suitable for CRC screening versus the iFOBT used in the NBCSP, as an intermediary test in the triage of individuals with positive iFOBT result for need and urgency to have a colonoscopy.<\/jats:p>\n 1. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray, F. GLOBOCAN 2012 v1.1, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11<\/jats:p>\n 2. National Bowel Cancer Screening Program: monitoring report 2012-2013. AIHW & Australian Government Department of Health and Ageing, 2014.<\/jats:p>\n 3. Fung KYC et al 2015. Blood-based protein biomarker panel for the detection of colorectal cancer. PloS one. 2015;10(3):e0120425.<\/jats:p>\n 4. Morikawa, T et al., A comparison of the immunochemical fecal occult blood test and total colonoscopy in the asymptomatic population. Gastroenterology, 2005. 129(2): p. 422-8.<\/jats:p>\n Citation Format: Leah J. Cosgrove, Kathy Surinya, Kim YC Fung, Ilka Priebe, Mike Buckley, Tim Adams, Bruce Tabor, Leanne Purins, Trevor Lockett, Hugo Leroux, Peter Gibbs, Jiangqin Wei, Ed Nice, Tony Burgess, Michelle Thomas, James Moore, Raj Singh, Andrew Ruszkiewicz. Evaluation of a diagnostic blood test for colorectal cancer screening and as a triage tool to stratify patients for colonoscopy. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4920.<\/jats:p>","DOI":"10.1158\/1538-7445.am2016-4920","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T18:04:21Z","timestamp":1469556261000},"page":"4920-4920","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Abstract 4920: Evaluation of a diagnostic blood test for colorectal cancer screening and as a triage tool to stratify patients for colonoscopy"],"prefix":"10.1158","volume":"76","author":[{"given":"Leah J.","family":"Cosgrove","sequence":"first","affiliation":[{"name":"1CSIRO, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Surinya","sequence":"additional","affiliation":[{"name":"1CSIRO, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim YC","family":"Fung","sequence":"additional","affiliation":[{"name":"2CSIRO, North Ryde, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilka","family":"Priebe","sequence":"additional","affiliation":[{"name":"1CSIRO, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Buckley","sequence":"additional","affiliation":[{"name":"2CSIRO, North Ryde, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Adams","sequence":"additional","affiliation":[{"name":"3CSIRO, Melbourne, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Tabor","sequence":"additional","affiliation":[{"name":"2CSIRO, North Ryde, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanne","family":"Purins","sequence":"additional","affiliation":[{"name":"1CSIRO, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Lockett","sequence":"additional","affiliation":[{"name":"2CSIRO, North Ryde, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Leroux","sequence":"additional","affiliation":[{"name":"4CSIRO, Brisbane, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Gibbs","sequence":"additional","affiliation":[{"name":"5WEHI, Melbourne, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangqin","family":"Wei","sequence":"additional","affiliation":[{"name":"1CSIRO, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ed","family":"Nice","sequence":"additional","affiliation":[{"name":"6Monash University, Melbourne, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Burgess","sequence":"additional","affiliation":[{"name":"5WEHI, Melbourne, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Thomas","sequence":"additional","affiliation":[{"name":"7Royal Adelaide Hospital, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Moore","sequence":"additional","affiliation":[{"name":"7Royal Adelaide Hospital, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj","family":"Singh","sequence":"additional","affiliation":[{"name":"8University of Adelaide, Adelaide, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Ruszkiewicz","sequence":"additional","affiliation":[{"name":"9University of SA, Adelaide, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/76\/14_Supplement\/4920\/612228\/Abstract-4920-Evaluation-of-a-diagnostic-blood","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/76\/14_Supplement\/4920\/612228\/Abstract-4920-Evaluation-of-a-diagnostic-blood","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T17:11:28Z","timestamp":1656090688000},"score":7.572369,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/76\/14_Supplement\/4920\/612228\/Abstract-4920-Evaluation-of-a-diagnostic-blood"}},"issued":{"date-parts":[[2016,7,15]]},"references-count":0,"journal-issue":{"issue":"14_Supplement","published-print":{"date-parts":[[2016,7,15]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2016-4920","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2016,7,15]]}},{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T03:53:24Z","timestamp":1649044404525},"reference-count":0,"publisher":"American 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A.","family":"Spry","sequence":"additional","affiliation":[{"name":"Westmead Hosp, Sydney, Australia; Sir Charles Gairdner Hosp, Perth, Australia; Westmead Millenium Institute, Sydney, Australia; Liverpool Health Service, Sydney, Australia; Sutherland Hosp, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Byth","sequence":"additional","affiliation":[{"name":"Westmead Hosp, Sydney, Australia; Sir Charles Gairdner Hosp, Perth, Australia; Westmead Millenium Institute, Sydney, Australia; Liverpool Health Service, Sydney, Australia; Sutherland Hosp, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"Berry","sequence":"additional","affiliation":[{"name":"Westmead Hosp, Sydney, Australia; Sir Charles Gairdner Hosp, Perth, Australia; Westmead Millenium Institute, Sydney, Australia; Liverpool Health Service, Sydney, Australia; Sutherland Hosp, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. J.","family":"Hayden","sequence":"additional","affiliation":[{"name":"Westmead Hosp, Sydney, Australia; Sir Charles Gairdner Hosp, Perth, Australia; Westmead Millenium Institute, Sydney, Australia; Liverpool Health Service, Sydney, Australia; Sutherland Hosp, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. I.","family":"Korbel","sequence":"additional","affiliation":[{"name":"Westmead Hosp, Sydney, Australia; Sir Charles Gairdner Hosp, Perth, Australia; Westmead Millenium Institute, Sydney, Australia; Liverpool Health Service, Sydney, Australia; Sutherland Hosp, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Woo","sequence":"additional","affiliation":[{"name":"Westmead Hosp, Sydney, Australia; Sir Charles Gairdner Hosp, Perth, Australia; Westmead Millenium Institute, Sydney, Australia; Liverpool Health Service, Sydney, Australia; Sutherland Hosp, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Gurney","sequence":"additional","affiliation":[{"name":"Westmead Hosp, Sydney, Australia; Sir Charles Gairdner Hosp, Perth, Australia; Westmead Millenium Institute, Sydney, Australia; Liverpool Health Service, Sydney, Australia; Sutherland Hosp, Sydney, 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Australia,Adelaide,Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanchang","family":"Zhao","sequence":"additional","affiliation":[{"name":"CSIRO,Data61,Canberra,Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Waters","sequence":"additional","affiliation":[{"name":"Maxima Training Group (Aust) 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on","author":"Yang","key":"ref42"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1109\/MSR.2017.58"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.physa.2015.10.039"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.dss.2018.10.003"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1177\/1527002514566278"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1145\/3097983.3098107"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1145\/2488388.2488509"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143093"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1972.tb00899.x"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780111409"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6893"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1609\/aaai.v32i1.11842"}],"event":{"name":"2022 IEEE International Conference on Big Data (Big Data)","start":{"date-parts":[[2022,12,17]]},"location":"Osaka, Japan","end":{"date-parts":[[2022,12,20]]}},"container-title":["2022 IEEE International Conference on Big Data (Big Data)"],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/10020192\/10020156\/10021126.pdf?arnumber=10021126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T06:08:19Z","timestamp":1707804499000},"score":7.571844,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/10021126\/"}},"issued":{"date-parts":[[2022,12,17]]},"references-count":53,"URL":"https:\/\/doi.org\/10.1109\/bigdata55660.2022.10021126","published":{"date-parts":[[2022,12,17]]}},{"indexed":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T16:11:55Z","timestamp":1681229515369},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2021,10,7]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Children commonly have access to mobile devices that allow them to send and receive texts at night when they should be sleeping. This may contribute to an increase in cyber-bullying and sleep problems, with negative effects on mental wellbeing.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Young children (7-11y, n = 22,597), early adolescents (12-14y, n = 19,470) and late adolescents (15-19y, n = 14,156) completed a survey examining mental wellbeing and the frequency of obtaining 8h sleep, texting at night and cyber-bullying.. Generalised structural equation modelling was used to investigate the effects of texting at night on mental wellbeing, directly, and indirectly via effects on sleep. Cyber-bullying was also specified as a moderator of the effect of texting at night on sleep.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Text messaging at night in the last week was reported by 51% and cyber-bullied in the last school term by 15% of children. For all children, obtaining at least 8h of sleep increased the odds of better mental wellbeing, Conversely, texting messaging and cyber-bullied reduced the odds of obtaining 8h sleep in both male and female young children and female early and late adolescents. In all cohorts except late adolescent males, obtaining less than 8h sleep and cyber-bullied accounted for a large proportion of the effects of text messaging on mental wellbeing.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Mobile phone use at night impairs sleep which contributes to poor mental wellbeing. The effect on sleep is exacerbated by cyber-bullying. Strategies to discourage small screen use at night, promote adequate sleep and reduce cyber-bullying are needed.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/sleepadvances\/zpab014.018","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T22:59:38Z","timestamp":1633647578000},"page":"A8-A9","source":"Crossref","is-referenced-by-count":0,"title":["O019 Mobile phone use at night, cyber-bullying, sleep, and mental wellbeing in young people aged 7 to 19 years"],"prefix":"10.1093","volume":"2","author":[{"given":"K","family":"Lushington","sequence":"first","affiliation":[{"name":"University of South Australia , Adelaide , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Dorrian","sequence":"additional","affiliation":[{"name":"University of South Australia , Adelaide , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Centofanti","sequence":"additional","affiliation":[{"name":"University of South Australia , Adelaide , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Wicking","sequence":"additional","affiliation":[{"name":"University of South Australia , Adelaide , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Wicking","sequence":"additional","affiliation":[{"name":"University of South Australia , Adelaide , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,7]]},"container-title":["SLEEP Advances"],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/sleepadvances\/article-pdf\/2\/Supplement_1\/A8\/49844122\/zpab014.018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/sleepadvances\/article-pdf\/2\/Supplement_1\/A8\/49844122\/zpab014.018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T15:55:01Z","timestamp":1681228501000},"score":7.571718,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleepadvances\/article\/2\/Supplement_1\/A8\/6383263"}},"issued":{"date-parts":[[2021,10,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2021,10,7]]}},"URL":"https:\/\/doi.org\/10.1093\/sleepadvances\/zpab014.018","ISSN":["2632-5012"],"issn-type":[{"value":"2632-5012","type":"electronic"}],"published-other":{"date-parts":[[2021,10,1]]},"published":{"date-parts":[[2021,10,1]]}},{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:10:26Z","timestamp":1788354626744,"version":"build-2803163510"},"reference-count":5,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:00:00Z","timestamp":1535328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Silver\u2010Russell syndrome (SRS OMIM 180860) is a rare, albeit well\u2010recognized disorder characterized by severe intrauterine and postnatal growth retardation. It remains a clinical diagnosis with a molecular cause identifiable in approximately 60%\u201370% of patients.<\/jats:p>We report a 4\u2010year\u2010old Australian Aboriginal girl who was born at 32\u2009weeks gestation with features strongly suggestive of SRS, after extensive investigation she was referred to our undiagnosed disease program (UDP). Genomic sequencing was performed which identified a heterozygous splice site variant in IGF2<\/jats:italic> which is predicted to be pathogenic by in\u2010silico studies, paternal allelic origin, de novo status, and RNA studies on fibroblasts. We compare clinical findings with reported patients to add to the knowledge base on IGF2<\/jats:italic> variants and to promote the engagement of other Australian Aboriginal families in genomic medicine.<\/jats:p>","DOI":"10.1002\/ajmg.a.40502","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T11:32:23Z","timestamp":1535455943000},"page":"2561-2563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Silver Russel syndrome in an aboriginal patient from Australia"],"prefix":"10.1002","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0763-6218","authenticated-orcid":false,"given":"Cathryn","family":"Poulton","sequence":"first","affiliation":[{"name":"Department of Neonatology Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Paediatrics Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitar","family":"Azmanov","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Genomics PathWest Laboratory Medicine Western Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Genomics PathWest Laboratory Medicine Western Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Beilby","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Genomics PathWest Laboratory Medicine Western Australia Nedlands Western Australia Australia"},{"name":"School of Pathology and Laboratory Medicine The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Ewans","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research, Kinghorn Centre for Clinical Genomics Darlinghurst New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Gration","sequence":"additional","affiliation":[{"name":"Genetic Services of Western Australia Subiaco Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Dreyer","sequence":"additional","affiliation":[{"name":"Genetic Services of Western Australia Subiaco Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinutha","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Perth Children's Hospital Foundation Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciara","family":"Peake","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Perth Children's Hospital Foundation Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"McCormack","sequence":"additional","affiliation":[{"name":"Faculty of Science, Doctor of Medicine Program University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Palmer","sequence":"additional","affiliation":[{"name":"School of Spatial Sciences Curtin University \u2010 Perth City Campus Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry PathWest Laboratory Medicine Western Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Dawkins","sequence":"additional","affiliation":[{"name":"Centre for Population Health Research Curtin University of Technology Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Broley","sequence":"additional","affiliation":[{"name":"Genetic Services of Western Australia Subiaco Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Baynam","sequence":"additional","affiliation":[{"name":"Genetic Services of Western Australia Subiaco Western Australia Australia"},{"name":"King Edward Memorial Hospital for Women Perth, Western Australia Register for Developmental Abnormalities Subiaco Western Australia Australia"},{"name":"Telethon Kids Institute Nedlands Western Australia Australia"},{"name":"School of Paediatrics and Child Health The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0619-z"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415227"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38199"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.138"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23253"}],"container-title":["American Journal of Medical Genetics Part A"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.40502","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.40502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T09:49:24Z","timestamp":1694684964000},"score":7.571587,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.40502"}},"issued":{"date-parts":[[2018,8,27]]},"references-count":5,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/ajmg.a.40502"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.40502","archive":["Portico"],"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"published":{"date-parts":[[2018,8,27]]},"assertion":[{"value":"2018-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:18:45Z","timestamp":1777929525465,"version":"3.51.4"},"reference-count":58,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nurs Ethics"],"published-print":{"date-parts":[[2019,5]]},"abstract":"\n Background:<\/jats:title>\n New graduate transition into the workforce is challenging and can involve managing ethical tensions. Ethical tensions cause new graduates to doubt their capabilities due to their lack of experience. To support new graduates, we need to know what these ethical tensions are.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n To explore the ethical tensions perceived to occur in practice for new graduate health professionals.<\/jats:p>\n <\/jats:sec>\n \n Research design:<\/jats:title>\n This qualitative systematic review involved a search of five databases (Medline, EMBASE, AMED, CINAHL and Scopus) which resulted in the retrieval of 3554 papers. After the two-phased screening process, eight studies were identified that met the inclusion criteria and had rich data on the review question. Articles were read several times, critically appraised and analysed through thematic analysis.<\/jats:p>\n <\/jats:sec>\n \n Ethical considerations:<\/jats:title>\n No ethical approval was required for the systematic review. The review was conducted following well-established reporting guidelines enabling transparency and rigour.<\/jats:p>\n <\/jats:sec>\n \n Findings:<\/jats:title>\n Studies originated from Australia, United States, Iran and China. One study included speech pathologists and seven were with nurses. Four themes included the following: (1) enduring an unknown workplace culture that generates uncertainty without support for new graduates; (2) being vulnerable because of distress from bullying, exclusion and being a scapegoat; (3) constraining systems and institutional restrictions that cause dilemmas; and (4) experiencing disillusionment from lost ideals about ethical practice.<\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n This review has brought to light the vulnerability of new graduates to negative workplace culture and collegial incivility. In addition, new graduates are subjected to ethical tensions created by institutional constraints which can create dilemmas and uncertainties through practice that does not align with what they anticipated.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Understanding ethical tensions experienced by new graduates enables provision of informed support. 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patient\u2010centred care, the ability to predict and prevent suboptimal post\u2010procedural outcomes based on patient demographics at admission may improve health equity. This study aimed to identify patient demographic characteristics that might predict disparities in mortality, readmission, and discharge outcomes after either an operative or non\u2010operative procedural hospital admission.<\/jats:p><\/jats:sec>Methods<\/jats:title>This retrospective cohort study included all surgical and non\u2010surgical procedural admissions at three of the four major metropolitan public hospitals in South Australia in 2022. Multivariable logistic regression, with backwards selection, evaluated association between patient demographic characteristics and outcomes up to 90\u2009days post\u2010procedurally.<\/jats:p><\/jats:sec>Results<\/jats:title>40\u2009882 admissions were included. Increased likelihood of all\u2010cause, post\u2010procedure mortality in\u2010hospital, at 30\u2009days, and 90\u2009days, were significantly associated with increased age (P<\/jats:italic>\u2009<\u20090.001), increased comorbidity burden (P<\/jats:italic>\u2009<\u20090.001), an emergency admission (P<\/jats:italic>\u2009<\u20090.001), and male sex (P<\/jats:italic>\u2009=\u20090.046, P<\/jats:italic>\u2009=\u20090.03, P<\/jats:italic>\u2009<\u20090.001, respectively). Identification as ATSI (P<\/jats:italic>\u2009<\u20090.001) and being born in Australia (P<\/jats:italic>\u2009=\u20090.03, P<\/jats:italic>\u2009=\u20090.001, respectively) were associated with an increased likelihood of 30\u2010day hospital readmission and decreased likelihood of discharge directly home, as was increased comorbidity burden (P<\/jats:italic>\u2009<\u20090.001) and emergency admission (P<\/jats:italic>\u2009<\u20090.001). Being married (P<\/jats:italic>\u2009<\u20090.001) and male sex (P<\/jats:italic>\u2009=\u20090.003) were predictive of an increased likelihood of discharging directly home; in contrast to increased age (P<\/jats:italic>\u2009<\u20090.001) which was predictive of decreased likelihood of this occurring.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This study characterized several associations between patient demographic factors present on admission and outcomes after surgical and non\u2010surgical procedures, that can be integrated within patient flow pathways through the Australian healthcare system to improve healthcare equity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18871","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T03:34:21Z","timestamp":1706672061000},"page":"96-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Achieving equity: patient demographics and outcomes 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The incidental findings were grouped into regions as follows: dentoalveolar structures, maxilla and mandible, paranasal sinuses, temporomandibular joint (TMJ), naso\/oral\u2010pharyngeal airway, cervical spine and neurovascular canals. The incidental findings are further categories into their significance towards the intended treatment plan.<\/jats:p><\/jats:sec>Result<\/jats:title>Incidental findings were noted on all of the scans. 555 incidental findings (1.85 findings\/scan) were identified. The highest number of incidental findings was in the sinuses (34%), followed by dentoalveolar structures (31%), nasal\/oral\u2010pharyngeal airway (12%), maxilla and mandible (10%), TMJ (6%), cervical spine (4%) and neurovascular canals (3%). A total of 37% of findings required follow\u2010up. 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It is expressed at high levels in a large variety of malignancies, where it is implicated in cytoprotection and drug resistance. Nevertheless, the pathways that mediate the cytoprotective functions of survivin and the mechanisms underlying its upregulation in cancer have not been fully elucidated. Results from our past investigations revealed that survivin was upregulated during telomerase-mediated immortalization of human myofibroblasts (MRC-5) (1). Since the immortalization process is an essential step in human carcinogenesis, upregulation of survivin during immortalization may explain why survivin is abundant in virtually all cancers. The present study aimed to characterize the mechanism responsible for the upregulation of survivin during immortalization, and the functional consequences of its over expression in immortal cells. Results from whole genome expression analyses and qRT-PCR demonstrated that the upregulation of survivin during immortalization was paralleled by increased expression of the transcription factor E2F1. The chromatin immunoprecipitation (ChIP) assay confirmed that E2F1 directly interacted with the survivin gene (BIRC5) promoter in immortal cells. Moreover, it was shown that E2F1 binding to BIRC5 was corresponded with repression of tumor suppressor p16INK4a, an event that commonly occurs during immortalization and human tumorigenesis. Survivin and p16INK4a were also functionally linked by assays that showed either upregulation of survivin or repression of p16INK4a rendered telomerase-transduced MRC-5 cells resistant to oxidative stress. Conversely, siRNA-mediated down regulation of survivin activated caspases and enhanced the sensitivity of immortal MRC-5 cells to oxidative stress. Together these data show that repression of p16INK4a contributes to the upregulation of survivin, and thereby provides a survival advantage to cells that are subject to oxidative stress during immortalization. 1. Yuan et al., Oncogene (2009) 28, 2678-2689.<\/jats:p>\n Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. 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During RP, removal of the anterior peri-prostatic fat (APPF) is commonly undertaken; some surgeons routinely request histopathological analysis of this specimen. Previously published data show positive cancer detection in peri-prostatic fat in 0\u20132.5% of specimens and positive yields are mostly detected in patients with adverse pathological features. <\/jats:p><\/jats:sec>Subjects and methods:<\/jats:title> All patients undergoing RP in a regional urology unit in Queensland were identified. Pathology results were examined retrospectively to determine the rate of cancer involvement in APPF specimens and medical records were reviewed to assess any clinical impact. <\/jats:p><\/jats:sec>Results:<\/jats:title> APPF was sent for pathological analysis in 270\/298 (90%) of patients undergoing RP. Prostate cancer was detected in one sample containing a single involved lymph node in a patient with Gleason 5 + 4 = 9 prostate cancer and pathological stage pT3bN1R1Mx. The presence of the cancer in the APPF did not affect the decision to offer adjuvant radiotherapy. <\/jats:p><\/jats:sec>Conclusion:<\/jats:title> In our population, we have identified a positive cancer yield of 0.3% in APPF specimens. When combined with all previously published series, we found positive cancer detection in 72\/7391 (1%) specimens, and most patients with positive fat involvement had adverse pre-operative and final pathological features. Surgeons may consider omitting sending APPF specimens for analysis based on the low yield with little additional staging information. If surgeons continue this practice, they should consider selectively requesting analysis in intermediate- and high-risk patients. <\/jats:p><\/jats:sec>Level of evidence:<\/jats:title> 2b <\/jats:p><\/jats:sec>","DOI":"10.1177\/2051415819843434","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T11:32:48Z","timestamp":1555068768000},"page":"19-24","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of histopathological analysis of anterior peri-prostatic fat in radical prostatectomy patients"],"prefix":"10.1177","volume":"13","author":[{"given":"Joseph","family":"Filby","sequence":"first","affiliation":[{"name":"Royal Gwent Hospital, Wales"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-5383","authenticated-orcid":false,"given":"Alexander 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History"}},{"value":"2023-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e20343"},{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:18:25Z","timestamp":1777879105120,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"5_suppl5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Orthopaedic Journal of Sports Medicine"],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"\n Background:<\/jats:title>\n The hamstring graft used in anterior cruciate ligament (ACL) reconstruction has been shown to lead to changes to the semitendinosus and gracilis musculature. This study further evaluated the effect of the surgery on hamstring muscle morphology and knee muscle strength at 2 years post-surgery.<\/jats:p>\n <\/jats:sec>\n \n Hypotheses:<\/jats:title>\n (1) Loss of donor muscle size would significantly correlate with knee muscle strength deficits (2) Loss of donor muscle size would be greater for muscles that do not experience tendon regeneration, and (3) Morphological adaptations would also be evident in non-donor knee muscles.<\/jats:p>\n <\/jats:sec>\n \n Study Design:<\/jats:title>\n Cross sectional evaluation.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n 20 participants (14 male, 6 female, 29 \u00b1 7 years, 82 \u00b1 15 kg) that had undergone a hamstring graft in ACL reconstruction at least two years previously, underwent bilateral MRI and subsequent strength testing. Muscle and tendon volumes, peak CSA\u2019s and lengths were determined for 12 muscles and 6 functional muscle groups of the surgical and contralateral limbs. Peak isokinetic concentric strength was measured in knee flexion\/extension and internal\/external tibial rotation.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Only 50% of the patients regenerated both the semitendinosus and gracilis tendons. The regenerated tendons were longer with larger volume and CSA compared to the contralateral side. Deficits in semitendinosus and gracilis muscle size were greater for tendons that did not regenerate. In addition, combined hamstrings (semitendinosus, semimembranosus, biceps femoris) and combined medial knee muscles (semitendinosus, semimembranosus, gracilis, vastus medialis, medial gastrocnemius, sartorius) on the surgical side were reduced in volume by 12% and 10% respectively. A 7% larger volume was observed in the surgical leg for the biceps femoris and corresponded with a lower internal\/external tibial rotation strength ratio. The difference in volume, peak CSA and length of the semitendinosus and gracilis correlated significantly with the deficit in knee flexion strength with Pearson correlations of 0.51, 0.57 and 0.61 respectively.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The muscle-tendon properties of the semitendinosus and gracilis are substantially altered following harvesting, and these alterations may contribute to knee flexor weakness in the surgical limb. These deficits are more pronounced in tendons that do not regenerate and are only partially offset by compensatory hypertrophy of other hamstring muscles.<\/jats:p>\n <\/jats:sec>\n \n Clinical Relevance:<\/jats:title>\n Surgeons should consider muscle retraction of the hamstring following tendon harvest in their choice of graft option for ACL reconstruction.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/2325967117s00181","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T15:56:51Z","timestamp":1496246211000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["HAMSTRING MORPHOLOGY AND STRENGTH REMAIN ALTERED 2 YEARS FOLLOWING A HAMSTRING GRAFT IN ACL RECONSTRUCTION"],"prefix":"10.1177","volume":"5","author":[{"given":"Christopher J.","family":"Vertullo","sequence":"first","affiliation":[{"name":"Knee Research Australia, Gold Coast, Australia"},{"name":"Menzies Health Institute, Griffith University, Gold Coast, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason M.","family":"Konrath","sequence":"additional","affiliation":[{"name":"Knee Research Australia, Gold Coast, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Knee Research Australia, Gold Coast, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamish","family":"Bush","sequence":"additional","affiliation":[{"name":"Knee Research Australia, Gold Coast, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney S.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Knee Research Australia, Gold Coast, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Knee Research Australia, Gold Coast, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,5,31]]},"container-title":["Orthopaedic Journal of Sports Medicine"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2325967117S00181","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2325967117S00181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:35:11Z","timestamp":1777592111000},"score":7.5705442,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2325967117S00181"}},"issued":{"date-parts":[[2017,5,1]]},"references-count":0,"journal-issue":{"issue":"5_suppl5","published-print":{"date-parts":[[2017,5,1]]}},"alternative-id":["10.1177\/2325967117S00181"],"URL":"https:\/\/doi.org\/10.1177\/2325967117s00181","ISSN":["2325-9671","2325-9671"],"issn-type":[{"value":"2325-9671","type":"print"},{"value":"2325-9671","type":"electronic"}],"published":{"date-parts":[[2017,5,1]]},"article-number":"2325967117S00181"},{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:23:47Z","timestamp":1774617827011,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australas J Ageing"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n The objectives of this study were to outline the establishment and operationalisation of the Older Adult Surgical Inpatient Service (OASIS), a proactive, perioperative geriatric medicine in\u2010reach service in a tertiary Acute Surgical Unit (ASU) and to describe the demographics, surgical diagnoses and management, and comprehensive geriatric assessment (CGA)\u2010based interventions of OASIS patients.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The Older Adult Surgical Inpatient Service (OASIS) was established in May 2021. Patients receiving OASIS input over 12 months were prospectively identified, and data were collected on baseline demographics, Clinical Frailty Scale (CFS), medical comorbidities, surgical diagnoses and initial CGA\u2010based interventions. Surgical management was retrospectively cross\u2010checked using digital medical records.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The Older Adult Surgical Inpatient Service (OASIS) was established by integrating a 0.5 FTE geriatrician in a tertiary hospital ASU. Older adults were identified for review at ASU handover. The Older Adult Surgical Inpatient Service (OASIS) conducted CGA\u2010based interventions on weekday ward rounds, supported by an ASU junior doctor. The geriatrician led the daily multidisciplinary team meeting. The Older Adult Surgical Inpatient Service (OASIS) reviewed 836 patients (median age\u2009=\u200978.5\u2009years). Prior to admission, 91% (\n n<\/jats:italic>\n =\u2009761) were community dwelling, 59% (\n n<\/jats:italic>\n =\u2009497) walked unaided and 60% (\n n<\/jats:italic>\n =\u2009505) were vulnerable or frail (CFS \u2265\u20094). Predominant surgical diagnoses were bowel obstruction 20% (\n n<\/jats:italic>\n =\u2009177), lower gastrointestinal bleeding 19% (\n n<\/jats:italic>\n =\u2009171) and acute biliary disease 18% (\n n<\/jats:italic>\n =\u2009162). Surgical management was operative in 26% (\n n<\/jats:italic>\n =\u2009215), non\u2010operative procedural in 20% (\n n<\/jats:italic>\n =\u2009175) and conservative in 53% (\n n<\/jats:italic>\n =\u2009446). There was a correlation between operative management decreasing as age and frailty increased. CGA\u2010based interventions on initial review included medication changes, goals of care discussions, anticoagulation management and perioperative risk assessment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n It is feasible to initiate a geriatric medicine in\u2010reach service in a tertiary hospital ASU by integrating a 0.5 FTE geriatrician into existing resources. A multi\u2010domain description of demographics, frailty, surgical diagnosis and management of older adults with acute surgical pathology is provided.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ajag.70134","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:20:12Z","timestamp":1770898812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Establishment of a Perioperative Geriatric Medicine Service in an Acute Surgical Unit\u2014Older Adult Surgical Inpatient Service (\n OASIS<\/scp>\n )"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0879-6923","authenticated-orcid":false,"given":"Rebecca","family":"Long","sequence":"first","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelne","family":"Thian","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aron","family":"Thian","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Cheng","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ainslie","family":"Jolliffe","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Murray","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viraji","family":"Hewage","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Foster","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Faculty of Health and Medical Sciences, School of Medicine University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Faculty of Health and Medical Sciences, School of Medicine University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7921-505X","authenticated-orcid":false,"given":"Anuttara Panchali W.","family":"Kumarasinghe","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Faculty of Health and Medical Sciences, School of Medicine University of Western Australia Crawley Western Australia Australia"},{"name":"Faculty of Health and Medical Sciences Curtin University Bentley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11148"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010126"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12827"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AIA.0000000000000396"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2019.6021"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17916"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02019-x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2020.03.023"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e3182a5a045"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.4088"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10459"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.14411"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.16728"},{"key":"e_1_2_10_15_1","unstructured":"J.Aitken B.Griffiths andE.O'Loughlin \u201cAustralian and New Zealand Emergency Laparotomy Audit\u2014Quality Improvement (ANZELA\u2010QI) \u201d(2020)."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.19026"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.19107"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2022.08.009"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.050051"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-020-01801-7"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afab245"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afac218.179"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.5770\/cgj.19.196"},{"issue":"3","key":"e_1_2_10_25_1","first-page":"149","article-title":"Opportunistic Screening for Atrial Fibrillation With a Single Lead Device in Geriatric Patients","volume":"17","author":"Zwart L. A.","year":"2020","journal-title":"Journal of Geriatric Cardiology: JGC"}],"container-title":["Australasian Journal on Ageing"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajag.70134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajag.70134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajag.70134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:41:11Z","timestamp":1774615271000},"score":7.5705357,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajag.70134"}},"issued":{"date-parts":[[2026,2,12]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/ajag.70134"],"URL":"https:\/\/doi.org\/10.1111\/ajag.70134","archive":["Portico"],"ISSN":["1440-6381","1741-6612"],"issn-type":[{"value":"1440-6381","type":"print"},{"value":"1741-6612","type":"electronic"}],"published":{"date-parts":[[2026,2,12]]},"assertion":[{"value":"2025-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70134"},{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:53:15Z","timestamp":1777855995147,"version":"3.51.4"},"reference-count":60,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T00:00:00Z","timestamp":1480896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Mens Health"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Men\u2019s participation in cancer screening may be influenced by their thinking style. Men\u2019s need for cognition (NFC) and faith in intuition were measured to explore whether they varied by demographic variables or predicted screening behavior. Australian males ( n = 585, aged 50-74 years) completed surveys about past screening and were subsequently offered mailed fecal occult blood tests (FOBTs). Demographic predictors included age, socioeconomic status, educational attainment, and language spoken at home. The screening behaviors were self-reported prostate cancer screening (prostate-specific antigen testing and digital rectal examinations [DREs]), and colorectal cancer screening (self-reported FOBT participation and recorded uptake of the FOBT offer). Analysis comprised principal component analysis and structural equation modelling. NFC was positively related to demographic variables education, socioeconomic status, and speaking English at home. Faith in intuition was negatively related to educational attainment. NFC predicted variance in self-reported DRE participation ( r = .11, p = .016). No other relationships with thinking style were statistically significant. The relationship of NFC to DRE participation may reflect the way certain attributes of this screening method are processed, or alternatively, it may reflect willingness to report participation. The relationship of thinking style to a range of healthy behaviors should be further explored.<\/jats:p>","DOI":"10.1177\/1557988316680913","type":"journal-article","created":{"date-parts":[[2016,12,6]],"date-time":"2016-12-06T20:20:16Z","timestamp":1481055616000},"page":"318-329","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Thinking Style as a Predictor of Men\u2019s Participation in Cancer Screening"],"prefix":"10.1177","volume":"11","author":[{"given":"Clare E.","family":"McGuiness","sequence":"first","affiliation":[{"name":"The University of Adelaide, Adelaide, South Australia, Australia"},{"name":"Freemasons Foundation Centre for Men\u2019s Health, Adelaide, South Australia, Australia"},{"name":"Commonwealth Scientific and Industrial Research Organisation, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Turnbull","sequence":"additional","affiliation":[{"name":"The University of Adelaide, Adelaide, South Australia, Australia"},{"name":"Freemasons Foundation Centre for Men\u2019s Health, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlene","family":"Wilson","sequence":"additional","affiliation":[{"name":"Cancer Council SA, Eastwood, South Australia, Australia"},{"name":"Flinders University, Bedford Park, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Duncan","sequence":"additional","affiliation":[{"name":"The University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid H.","family":"Flight","sequence":"additional","affiliation":[{"name":"Commonwealth Scientific and Industrial Research Organisation, Adelaide, South Australia, Australia"},{"name":"Flinders University, Bedford Park, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Zajac","sequence":"additional","affiliation":[{"name":"Commonwealth Scientific and Industrial Research Organisation, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,12,5]]},"reference":[{"key":"bibr1-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1016\/0749-5978(91)90020-T"},{"key":"bibr2-1557988316680913","volume-title":"2011 Census: Education and qualifications","author":"Australian Bureau of Statistics","year":"2011"},{"key":"bibr3-1557988316680913","unstructured":"Australian Bureau of Statistics. (2013a). Causes of death, Australia, 2012 (Cat. No. 3303.0). Retrieved from http:\/\/www.abs.gov.au\/AUSSTATS\/abs@.nsf\/allprimarymainfeatures\/47E19CA15036B04BCA2577570014668B"},{"key":"bibr4-1557988316680913","volume-title":"IRSAD","author":"Australian Bureau of Statistics","year":"2013"},{"key":"bibr5-1557988316680913","unstructured":"Australian Bureau of Statistics. (2013c). Perspectives on education and training: Social inclusion, 2009 (Cat. No. 4250.0.55.001). Retrieved from http:\/\/www.abs.gov.au\/ausstats\/abs@.nsf\/Lookup\/4250.0.55.001Main+Features32009"},{"key":"bibr6-1557988316680913","unstructured":"Australian Institute of Health and Welfare. (2012). Australia\u2019s health 2012 (Cat. No. AUS 156). Retrieved from http:\/\/www.aihw.gov.au\/WorkArea\/DownloadAsset.aspx?id=10737422169"},{"key":"bibr7-1557988316680913","unstructured":"Australian Institute of Health and Welfare. (2013). Prostate cancer in Australia (Cat. No. CAN 76). Retrieved from http:\/\/www.aihw.gov.au\/WorkArea\/DownloadAsset.aspx?id=60129545133"},{"key":"bibr8-1557988316680913","unstructured":"Australian Institute of Health and Welfare. (2014). National Bowel Cancer Screening Program monitoring report: 2012\u201313 (Cat. No. CAN 81). Retrieved from http:\/\/www.aihw.gov.au\/WorkArea\/DownloadAsset.aspx?id=60129547719"},{"key":"bibr9-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1080\/08870449808407422"},{"key":"bibr10-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909-130.6.887"},{"key":"bibr11-1557988316680913","volume-title":"Understanding hard to maintain behaviour change: A dual process approach","author":"Borland R.","year":"2014"},{"key":"bibr12-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2005.09.007"},{"key":"bibr13-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2015.03.009"},{"key":"bibr14-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.42.1.116"},{"key":"bibr15-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.119.2.197"},{"key":"bibr16-1557988316680913","unstructured":"Cancer Council Australia. (2016a). Prostate cancer detection. Retrieved from http:\/\/www.cancer.org.au\/about-cancer\/early-detection\/prostate-cancer-screening.html"},{"key":"bibr17-1557988316680913","unstructured":"Cancer Council Australia. (2016b). Screening programs. Retrieved from http:\/\/www.cancer.org.au\/about-cancer\/early-detection\/screening-programs\/"},{"key":"bibr18-1557988316680913","doi-asserted-by":"publisher","DOI":"10.2105\/Ajph.94.8.1336"},{"key":"bibr19-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1177\/0146167207309194"},{"key":"bibr20-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1037\/a0029305"},{"key":"bibr21-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1071\/Py13078"},{"key":"bibr22-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2012.11.016"},{"key":"bibr23-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1977.tb01600.x"},{"key":"bibr24-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.9004"},{"key":"bibr25-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-14-239"},{"key":"bibr26-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1002\/0471264385.wei0507"},{"key":"bibr27-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.71.2.390"},{"key":"bibr28-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1177\/1745691612460685"},{"key":"bibr29-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.51.4.875"},{"key":"bibr30-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605962"},{"key":"bibr31-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1080\/15298868.2010.536417"},{"key":"bibr32-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1027\/1614-0001\/A000119"},{"key":"bibr33-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2004.03331.x"},{"key":"bibr34-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980014000652"},{"key":"bibr35-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001216.pub2"},{"key":"bibr36-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1080\/17437190802617668"},{"key":"bibr37-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004720.pub3"},{"key":"bibr38-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1002\/bdm.752"},{"key":"bibr39-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1177\/0969141315599015"},{"key":"bibr40-1557988316680913","unstructured":"Medicare Australia. (2015). Medicare item reports for MBS 66655 and 66656 during 2014. Retrieved from https:\/\/www.medicareaustralia.gov.au\/statistics\/mbs_item.shtml"},{"key":"bibr41-1557988316680913","doi-asserted-by":"publisher","DOI":"10.3109\/13685538.2010.522277"},{"key":"bibr42-1557988316680913","volume-title":"Prostate-specific antigen (PSA) testing in asymptomatic men: Evidence evaluation report 2013","author":"National Health and Medical Research Council","year":"2013"},{"key":"bibr43-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa5103_11"},{"key":"bibr44-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1037\/a0038154"},{"key":"bibr45-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.76.6.972"},{"key":"bibr46-1557988316680913","doi-asserted-by":"publisher","DOI":"10.4278\/0890-1171-12.1.38"},{"key":"bibr47-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965"},{"key":"bibr48-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1177\/109019817400200403"},{"key":"bibr49-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1037\/a0029203"},{"key":"bibr50-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1503\/Cmaj.1031921"},{"key":"bibr51-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2007.11.002"},{"key":"bibr52-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2010.07.028"},{"key":"bibr53-1557988316680913","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1999.tb123594.x"},{"key":"bibr54-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1111\/jopy.12007"},{"key":"bibr55-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-005691"},{"key":"bibr56-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1071\/AH13092"},{"key":"bibr57-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1111\/j.0021-9029.2007.00149.x"},{"key":"bibr58-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/949837"},{"key":"bibr59-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1207\/S15327027HC1504_01"},{"key":"bibr60-1557988316680913","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2016.06.036"}],"container-title":["American Journal of Men's Health"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1557988316680913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1557988316680913","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1557988316680913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:33:39Z","timestamp":1777505619000},"score":7.5704737,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1557988316680913"}},"issued":{"date-parts":[[2016,12,5]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1177\/1557988316680913"],"URL":"https:\/\/doi.org\/10.1177\/1557988316680913","ISSN":["1557-9883","1557-9891"],"issn-type":[{"value":"1557-9883","type":"print"},{"value":"1557-9891","type":"electronic"}],"published":{"date-parts":[[2016,12,5]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:35:43Z","timestamp":1753889743634,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,6,1]]},"abstract":"Objective: To assess whether improvements in preventative care for people with diabetes have resulted in a relative decrease in the burden of coronary artery disease (CAD) compared to people without diabetes.<\/jats:p>\n Methods: All patient-level linked coronary angiography and hospital separation data at a large Australian tertiary referral hospital between 2013 and 2019 were obtained. Indication for angiography and extent of CAD were based on original classification by treating cardiologists, classified as no disease, mild, moderate or severe. Propensity scores were estimated to match people with and without diabetes on a 1:1 ratio. Ordinal logistic regression models were fitted to assess trends in CAD severity in people with and without diabetes over time with adjusted odds ratios (adjOR) reported.<\/jats:p>\n Results: For 3,016 people identified in the coronary angiography database and matched using propensity scores, 1508(50%) were diagnosed with diabetes. Angiographic evidence of CAD was detected in 1155(77%) and 1257(83%) people without and with diabetes. For people with diabetes there was an increased risk of more extensive CAD in 2018 compared to 2013 (adjOR: 2.02 95% C.I. 1.36, 2.99). This risk appears to have been attenuated in 2019 with no significant change in CAD burden between 2013 and 2019 (adjOR: 1.33 95% C.I. 0.90, 1.98). In contrast, there was no effect of time on CAD burden in people without diabetes.<\/jats:p>\n Conclusions: The initial increase in severity of disease burden seen in our study for people with diabetes compared to those without diabetes may represent improved CAD screening rather than suboptimal application of preventative therapies. Possibly, greater recent use of newer glucose lowering medications with cardiovascular protective effects accounts for the attenuation of CAD burden in 2019 for people with diabetes. These findings highlight the importance of aggressive risk factor modification for people with diabetes to minimize the development and progression of CAD.<\/jats:p>\n \n Disclosure<\/jats:title>\n K.V. Kiburg: None. A.I. MacIsaac: None. V. Sundararajan: None. R. MacIsaac: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db20-416-p","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T16:29:52Z","timestamp":1592238592000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["416-P: Change in Extent of Coronary Artery Disease in People with and without Diabetes Undergoing Coronary Angiography"],"prefix":"10.2337","volume":"69","author":[{"given":"KATERINA V.","family":"KIBURG","sequence":"first","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREW I.","family":"MACISAAC","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VIJAYA","family":"SUNDARARAJAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"MACISAAC","sequence":"additional","affiliation":[{"name":"Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/416-P\/56502\/416-P-Change-in-Extent-of-Coronary-Artery-Disease","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/416-P\/56502\/416-P-Change-in-Extent-of-Coronary-Artery-Disease","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T09:30:42Z","timestamp":1647163842000},"score":7.5704308,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/69\/Supplement_1\/416-P\/56502\/416-P-Change-in-Extent-of-Coronary-Artery-Disease"}},"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db20-416-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2020,6,1]]},"article-number":"416-P"},{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T22:59:27Z","timestamp":1648594767603},"reference-count":0,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"18_suppl","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2007,6,20]]},"abstract":" 5515 <\/jats:p> Background: Mucin 1 (MUC1) is a glycoprotein highly expressed by ovarian carcinoma and is thus a potential antigen for immunotherapy. Following successful phase I results (Loveland et al. Clin Can Res 2006; 12:869), using DC pulsed with mannan-MUC1 fusion protein (DC-MFP), we report a phase II trial in similarly treated pts with ovarian carcinoma. Methods: Eligibility: incurable disease; age = 18 yrs; PS 0\u20132; no autoimmune disorders; rising CA125 levels (= 25% in 1 mth, confirmed). The primary endpoint was CA125 response (major = 50%, minor = 25%, each confirmed at = 4 wk) or stabilisation (= 3 mths). PBMC were collected by leukapheresis, cultured with IL-4 and GM-CSF to generate DC, and pulsed with MFP on d5. DC were reinjected on d6 as 8 i.d. injections (each 5x106<\/jats:sup>), given 4-weekly \u00d7 3, then 10- weekly to 12 mths. Excess cells were cryopreserved for subsequent injections. Results: 28 pts were recruited, with all evaluable for toxicity and 21 for efficacy (received = 3 vaccinations). Characteristics were: serous histology 24 (86%) pts; median age 58 yrs (34\u201378); PS 0\u20131 27 (96%) pts; prior systemic therapy (all pts platinum-treated) 1 line 5 pts, 2 line 4 pts, 3 line 10 pts, = 4 lines 9 pts. Leukapheresis was generally required only 6-monthly. Following ex vivo culture, the proportion of CD86+ cells ranged from 40 - 85%. There was no grade = 3 therapy-related toxicity. Of 21 pts, 4 (19%) showed CA125 response or stabilisation. 2 pts had major response: 1 pt with 4 previous lines of systemic therapy (DC-MFP response duration 12+ mths) and 1 pt treated second line (duration 14 mths). One pt had stable disease of 7 mths duration which included 10 wks classified as minor response and one pt, treated fifth-line, had stable disease for 5 mths. An additional pt, treated fourth-line, had >25% CA125 reduction which was not confirmed by repeat CA125. CT scan results were generally concordant with CA125 status. No relationship was seen between clinical benefit and HLA type. 88% of tumours were MUC1+ on IHC. Conclusions: Study treatment was well tolerated and acceptable to pts. There was clear evidence of clinical benefit, including pts who were heavily pre-treated. This approach warrants further study in ovarian carcinoma. Supported by grants from PrimaBiomed Ltd. <\/jats:p> No significant financial relationships to disclose. <\/jats:p>","DOI":"10.1200\/jco.2007.25.18_suppl.5515","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T20:52:55Z","timestamp":1583527975000},"page":"5515-5515","source":"Crossref","is-referenced-by-count":0,"title":["Durable clinical responses in patients (pts) with ovarian carcinoma treated on a phase II trial of autologous dendritic cells (DC) pulsed with MUC1"],"prefix":"10.1200","volume":"25","author":[{"given":"P.","family":"Mitchell","sequence":"first","affiliation":[{"name":"Austin Hospital, Melbourne, Australia; Burnet Institute, Melbourne, Australia; Royal Womens Hospital, Melbourne, Australia; Mercy Hospital for Women, Melbourne, Australia; Monash Medical Centre, Melbourne, Australia; Centre for Blood Cell Therapies, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. E.","family":"Loveland","sequence":"additional","affiliation":[{"name":"Austin Hospital, Melbourne, Australia; Burnet Institute, Melbourne, Australia; Royal Womens Hospital, Melbourne, Australia; Mercy Hospital for Women, Melbourne, Australia; Monash Medical Centre, Melbourne, Australia; Centre for Blood Cell Therapies, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Austin Hospital, Melbourne, Australia; Burnet Institute, Melbourne, Australia; Royal Womens Hospital, Melbourne, Australia; Mercy Hospital for Women, Melbourne, Australia; Monash Medical Centre, Melbourne, Australia; Centre for Blood Cell Therapies, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. T.","family":"Grant","sequence":"additional","affiliation":[{"name":"Austin Hospital, Melbourne, Australia; Burnet Institute, Melbourne, Australia; Royal Womens Hospital, Melbourne, Australia; Mercy Hospital for Women, Melbourne, Australia; Monash Medical Centre, Melbourne, Australia; Centre for Blood Cell Therapies, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. G.","family":"Allen","sequence":"additional","affiliation":[{"name":"Austin Hospital, Melbourne, Australia; Burnet Institute, Melbourne, Australia; Royal Womens Hospital, Melbourne, Australia; Mercy Hospital for Women, Melbourne, Australia; Monash Medical Centre, Melbourne, Australia; Centre for Blood Cell Therapies, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. W.","family":"Jobling","sequence":"additional","affiliation":[{"name":"Austin Hospital, Melbourne, Australia; Burnet Institute, Melbourne, Australia; Royal Womens Hospital, Melbourne, Australia; Mercy Hospital for Women, Melbourne, Australia; Monash Medical Centre, Melbourne, Australia; Centre for Blood Cell Therapies, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C.","family":"White","sequence":"additional","affiliation":[{"name":"Austin Hospital, Melbourne, Australia; Burnet Institute, Melbourne, Australia; Royal Womens Hospital, Melbourne, Australia; Mercy Hospital for Women, Melbourne, Australia; Monash Medical Centre, Melbourne, Australia; Centre for Blood Cell Therapies, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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In 15 Australian patients undergoing total pancreatectomy and islet auto transplantation (TPIAT), we observed a marked reduction in hospital admissions, inpatient days and emergency visits, complete analgesic cessation by 24 months and durable insulin independence in nearly half of the patients. These findings highlight TPIAT\u2019s potential to improve quality of life and reduce healthcare burden. 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It draws on the concept of marronage\u2014a term rooted in the fugitive act of becoming a maroon, where enslaved people enacted an escape in search of refuge and autonomy within or beyond the structures of slavery. Within this framework, the student\u2010supervisor relationship is reimagined as a relational practice that embodies collectivity and care. We conceptualise the relationality within the group as a form of Marronage, shedding light on how WhatsApp group interactions and reflections from fortnightly virtual meetings offer sustenance, joy and resistance to the institutional anti\u2010Blackness of the academy and wider society. The agency exercised by this community is theorised in terms of maroon moves, in which Black sociability and joy intersect with and interrupt the institutional logics of and hierarchies governing higher education. In the contexts of alienation and atomisation in student experience, our contribution offers new perspectives on how graduate study can be conceptualised and organised to challenge the coloniality of higher education and nourish Black students on their journey through it.<\/jats:p>","DOI":"10.1002\/ajs4.70054","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T06:28:41Z","timestamp":1754116121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Building Community Amidst the Institutional Whiteness of Graduate Study: Black Joy and Maroon Moves in an Academic Marronage"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4463-8033","authenticated-orcid":false,"given":"Hellen","family":"Magoi","sequence":"first","affiliation":[{"name":"UniSA Education Futures University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0770-6471","authenticated-orcid":false,"given":"Casianus","family":"Gemoh","sequence":"additional","affiliation":[{"name":"UniSA Education Futures University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5279-5218","authenticated-orcid":false,"given":"Denise","family":"Chapman","sequence":"additional","affiliation":[{"name":"Faculty of Education Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2530-7614","authenticated-orcid":false,"given":"Edmund","family":"Hypolite","sequence":"additional","affiliation":[{"name":"UniSA Education Futures University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Angok","sequence":"additional","affiliation":[{"name":"UniSA Education Futures University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0745-1352","authenticated-orcid":false,"given":"Melanie","family":"Baak","sequence":"additional","affiliation":[{"name":"UniSA Education Futures University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8544-9215","authenticated-orcid":false,"given":"Joel","family":"Windle","sequence":"additional","affiliation":[{"name":"UniSA Education Futures University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2979\/transition.126.1.11"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2307\/jj.5425951.19","volume-title":"When Will the Joy Come?: Black Women in the Ivory Tower","author":"Accilien C.","year":"2023"},{"key":"e_1_2_11_4_1","volume-title":"The Black PhD Experience: Stories of Strength, Courage and Wisdom in UK Academia","author":"Ackah W.","year":"2024"},{"issue":"22","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.1503\/cmaj.231753","article-title":"Variegated Racism: Exploring Experiences of Anti\u2010Black Racism and Their Progression in Medical Education","volume":"196","author":"Alhassan J. 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Comput."},{"key":"ref37","article-title":"Addressing fault and calibration in wireless sensor networks","author":"Balzano","year":"2007"},{"key":"ref38","first-page":"1","article-title":"Reliable informational data and secured deviation notification over networks using IoT","volume-title":"Proc. Int. Conf. Recent Trends Electron. Commun. (ICRTEC)","author":"Vyshali Rao"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1109\/TITS.2021.3059261"}],"container-title":["IEEE Internet of Things Journal"],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/6488907\/6702522\/10679141.pdf?arnumber=10679141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T06:13:32Z","timestamp":1734761612000},"score":7.569379,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/10679141\/"}},"issued":{"date-parts":[[2024]]},"references-count":39,"URL":"https:\/\/doi.org\/10.1109\/jiot.2024.3459477","ISSN":["2327-4662","2372-2541"],"issn-type":[{"value":"2327-4662","type":"electronic"},{"value":"2372-2541","type":"electronic"}],"published":{"date-parts":[[2024]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:42:01Z","timestamp":1753890121176,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,6,14]]},"abstract":"Background: Duodenal dysfunction, specifically in nutrient sensing, iron homeostasis, and inflammation is linked to Type 2 Diabetes. This study assesses Endoscopic Re-Cellularization via Electroporation Therapy (ReCET\u2122), an outpatient procedure using non-thermal pulsed electric field to regenerate the duodenal function.<\/jats:p>\n Methods: Participants (18-70 years, BMI 24-40 kg\/m\u00b2, HbA1c 7.5%-11.0%, on 1-4 non-insulin antidiabetics) received PEF. Primary endpoints were serious adverse events at 12 weeks, with secondary endpoints including efficacy and response predictors at 24 weeks.<\/jats:p>\n Results: 71 patients (age 55, 73% male, BMI 31.7 kg\/m\u00b2, T2D duration 5.8 years, baseline HbA1c 8.6%) participated. Treatment groups received either low or high energy doses. No SAEs occurred. The high energy group exhibited significant glycemic improvement (-1.11 HbA1c reduction vs. -0.32 in low energy group, p=0.015) and improved Time in Range, %TBWL, HOMA-IR, Triglyceride, and Ferritin. Baseline Ferritin and HbA1c were predictors of response (figure 1). Subgroup with baseline Ferritin \u2265200 and HbA1c \u22658 showed a -2.04 [95%CI -3.94, -0.14] HbA1c reduction at 24 weeks with high energy.<\/jats:p>\n Conclusions: ReCET\u2122 enhances glycemic control in T2D without SAEs, impacting weight, lipid profile, and iron metabolism. This suggests a novel mechanism complementing existing T2D treatments.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n B.K. Abu Dayyeh: Research Support; USGI Medical, Apollo Endosurgery. Consultant; Boston Scientific Corporation, Medtronic. Other Relationship; Endogenex. Research Support; ERBE. A. Sartoretto: Research Support; Endogenex, Erbe Electromedizin GmbH. Advisory Panel; Bariatek. Consultant; Boston Scientific Corporation, Intuitive Surgical. A.C. Storm: Consultant; Intuitive Surgical, Boston Scientific Corporation, Olympus. Research Support; Apollo Endosurgery, Endogenex, Microtech. Consultant; Enterasense. Research Support; OnePass. H.M. McCollister: Consultant; Endogenex. P.A. Severson: Consultant; Endogenex. B. Holt: None. G. Cameron: None. R. Vaughan: None. J. Lipham: Consultant; Endogenex, Ethicon, Inc., Implantica. E.I. Ekinci: Advisory Panel; Lilly Diabetes. Research Support; Novo Nordisk, Boehringer-Ingelheim, Eli Lilly and Company. Board Member; Eli Lilly and Company. Advisory Panel; Abbott. Research Support; Endogenex, Versanis, AstraZeneca. D.N. O'Neal: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db24-881-p","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:20:36Z","timestamp":1718349636000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["881-P: Optimizing Glycemic Control in Type 2 Diabetes Using Novel Endoscopic Pulsed Electric Field Therapy\u2014A Study of Outcomes and Predictive Factors"],"prefix":"10.2337","volume":"73","author":[{"given":"BARHAM K.","family":"ABU DAYYEH","sequence":"first","affiliation":[{"name":"Rochester, MN, Double Bay, Australia, Crosby, MN, Deerwood, MN, Heidelberg, Australia, Los Angeles, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ADRIAN","family":"SARTORETTO","sequence":"additional","affiliation":[{"name":"Rochester, MN, Double Bay, Australia, Crosby, MN, Deerwood, MN, Heidelberg, Australia, Los Angeles, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREW C.","family":"STORM","sequence":"additional","affiliation":[{"name":"Rochester, MN, Double Bay, Australia, Crosby, MN, Deerwood, MN, Heidelberg, Australia, Los Angeles, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HOWARD M.","family":"MCCOLLISTER","sequence":"additional","affiliation":[{"name":"Rochester, MN, Double Bay, Australia, Crosby, MN, Deerwood, MN, Heidelberg, Australia, Los Angeles, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAUL A.","family":"SEVERSON","sequence":"additional","affiliation":[{"name":"Rochester, MN, Double Bay, Australia, Crosby, MN, Deerwood, MN, Heidelberg, Australia, Los Angeles, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRONTE","family":"HOLT","sequence":"additional","affiliation":[{"name":"Rochester, MN, Double Bay, Australia, Crosby, MN, Deerwood, MN, Heidelberg, Australia, Los Angeles, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GEORGINA","family":"CAMERON","sequence":"additional","affiliation":[{"name":"Rochester, MN, Double Bay, Australia, Crosby, MN, Deerwood, MN, Heidelberg, Australia, Los Angeles, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RHYS","family":"VAUGHAN","sequence":"additional","affiliation":[{"name":"Rochester, MN, Double Bay, Australia, Crosby, MN, Deerwood, MN, Heidelberg, Australia, Los Angeles, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN","family":"LIPHAM","sequence":"additional","affiliation":[{"name":"Rochester, MN, Double Bay, Australia, Crosby, MN, Deerwood, MN, Heidelberg, Australia, Los Angeles, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIF I.","family":"EKINCI","sequence":"additional","affiliation":[{"name":"Rochester, MN, Double Bay, Australia, Crosby, MN, Deerwood, MN, Heidelberg, Australia, Los Angeles, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID N.","family":"O'NEAL","sequence":"additional","affiliation":[{"name":"Rochester, MN, Double Bay, Australia, Crosby, MN, Deerwood, MN, Heidelberg, Australia, Los Angeles, CA, Melbourne, Australia, Fitzroy, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/881-P\/156557\/881-P-Optimizing-Glycemic-Control-in-Type-2","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/881-P\/156557\/881-P-Optimizing-Glycemic-Control-in-Type-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:20:36Z","timestamp":1718349636000},"score":7.569369,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/73\/Supplement_1\/881-P\/156557\/881-P-Optimizing-Glycemic-Control-in-Type-2"}},"issued":{"date-parts":[[2024,6,14]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2024,6,14]]}},"URL":"https:\/\/doi.org\/10.2337\/db24-881-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2024,6,14]]},"article-number":"881-P"},{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:10:46Z","timestamp":1784196646555,"version":"3.55.0"},"reference-count":72,"publisher":"American Diabetes Association","issue":"2","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2023,5,1]]},"abstract":"Regular physical activity and exercise are important for youth and essential components of a healthy lifestyle. For youth with type 1 diabetes, regular physical activity can promote cardiovascular fitness, bone health, insulin sensitivity, and glucose management. However, the number of youth with type 1 diabetes who regularly meet minimum physical activity guidelines is low, and many encounter barriers to regular physical activity. Additionally, some health care professionals (HCPs) may be unsure how to approach the topic of exercise with youth and families in a busy clinic setting. This article provides an overview of current physical activity research in youth with type 1 diabetes, a basic description of exercise physiology in type 1 diabetes, and practical strategies for HCPs to conduct effective and individualized exercise consultations for youth with type 1 diabetes.<\/jats:p>","DOI":"10.2337\/dsi22-0020","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T18:45:40Z","timestamp":1684176340000},"page":"137-145","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":3,"title":["Physical Activity Management for Youth With Type 1 Diabetes: Supporting Active and Inactive Children"],"prefix":"10.2337","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4244-5473","authenticated-orcid":false,"given":"Elizabeth A.","family":"Davis","sequence":"first","affiliation":[{"name":"1Department of Endocrinology and Diabetes, Perth Children\u2019s Hospital, Perth, Western Australia, Australia"},{"name":"2Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia"},{"name":"3Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinutha B.","family":"Shetty","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology and Diabetes, Perth Children\u2019s Hospital, Perth, Western Australia, Australia"},{"name":"2Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia"},{"name":"3Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun Y.M.","family":"Teo","sequence":"additional","affiliation":[{"name":"2Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel J.","family":"Lim","sequence":"additional","affiliation":[{"name":"2Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-6965","authenticated-orcid":false,"given":"Susana R.","family":"Patton","sequence":"additional","affiliation":[{"name":"4Nemours Children\u2019s Health, Jacksonville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig E.","family":"Taplin","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology and Diabetes, Perth Children\u2019s Hospital, Perth, Western Australia, Australia"},{"name":"2Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia"},{"name":"3Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"2023051514085613600_B1","doi-asserted-by":"crossref","first-page":"107810","DOI":"10.1016\/j.diabres.2019.107810","article-title":"Benefits of physical activity in children and adolescents with type 1 diabetes: a systematic review","volume":"156","author":"Absil","year":"2019","journal-title":"Diabetes Res Clin Pract"},{"key":"2023051514085613600_B2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1123\/pes.2014-0074","article-title":"Sedentary time and screen-based sedentary behaviors of children with a chronic disease","volume":"27","author":"Walker","year":"2015","journal-title":"Pediatr Exerc Sci"},{"key":"2023051514085613600_B3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/pedi.12117","article-title":"Fitness and physical activity in youth with type 1 diabetes mellitus in good or poor glycemic control","volume":"16","author":"Nguyen","year":"2015","journal-title":"Pediatr Diabetes"},{"key":"2023051514085613600_B4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/pedi.12755","article-title":"ISPAD Clinical Practice Consensus Guidelines 2018: exercise in children and adolescents with diabetes","volume":"19","author":"Adolfsson","year":"2018","journal-title":"Pediatr Diabetes"},{"key":"2023051514085613600_B5","unstructured":"World Health Organization\n . Physical activity. Available from https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/physical-activity. 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While family caregivers indicate a need for more information about bereavement, there is little evidence to guide what this information might contain.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n The study\u2019s purpose was to inform bereavement support by determining the advice people bereaved through expected deaths in palliative care have for others in that situation.<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n Four funeral providers posted a questionnaire to previous clients who had used their services 6 to 24 months prior and 678 bereaved people responded.<\/jats:p>\n <\/jats:sec>\n \n Setting\/Participants:<\/jats:title>\n The sample size for this study comprised 265 bereaved people whose relative used palliative care services.<\/jats:p>\n <\/jats:sec>\n \n Measurements:<\/jats:title>\n The questionnaire comprised 82 questions about caregiving, bereavement support, current bereavement-related distress, and 2 open-ended questions concerning their bereavement, one of them on advice they have to other people in the same situation.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Family caregivers (n = 140) of people who received palliative care responded to the open-ended question about advice for others. An open content analysis yielded 3 themes\u2014preparations for bereavement, utilizing social networks, and strategies for dealing with grief.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Bereaved family caregivers\u2019 experiential knowledge can be harnessed to progress the development of bereavement care strategies for the good of the community. These responses could be incorporated into information brochures, posters, and other community education avenues in order to upskill palliative care bereavement volunteers and the wider community so that bereaved family caregivers are best supported.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/1049909115615568","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T20:43:38Z","timestamp":1447447418000},"page":"275-281","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":50,"title":["Building Community Capacity in Bereavement Support"],"prefix":"10.1177","volume":"34","author":[{"given":"Lauren J.","family":"Breen","sequence":"first","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar M.","family":"Aoun","sequence":"additional","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Rumbold","sequence":"additional","affiliation":[{"name":"La Trobe University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverley","family":"McNamara","sequence":"additional","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise A.","family":"Howting","sequence":"additional","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Mancini","sequence":"additional","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"bibr1-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2011.0466"},{"key":"bibr2-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1179\/1743291X12Y.0000000003"},{"key":"bibr3-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1080\/07481187.2012.725451"},{"key":"bibr4-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-6405.2012.00825.x"},{"key":"bibr5-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121101"},{"key":"bibr6-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hct200"},{"key":"bibr7-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1080\/09581596.2014.909582"},{"key":"bibr8-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1179\/1743291X13Y.0000000079"},{"key":"bibr9-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000121"},{"key":"bibr10-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1002\/da.20780"},{"key":"bibr11-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2006.9.694"},{"key":"bibr12-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2008.0237"},{"key":"bibr13-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1089\/10966210260499069"},{"key":"bibr14-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1080\/15524256.2011.593153"},{"key":"bibr15-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2005.8.713"},{"key":"bibr16-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2013.0157"},{"key":"bibr17-1049909115615568","doi-asserted-by":"crossref","unstructured":"Horey D, Street AF, O\u2019Connor M, Training and supportive programs for palliative care volunteers in community settings. Cochrane Database of Systematic Reviews. 2015;7. Web site. http:\/\/dx.doi.org\/10.1002\/14651858.CD009500.pub2\/pdf\/abstract.","DOI":"10.1002\/14651858.CD009500.pub2"},{"key":"bibr18-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1191\/026921601668727250"},{"issue":"2","key":"bibr19-1049909115615568","first-page":"61","volume":"5","author":"Relf M","year":"1988","journal-title":"Eur J Palliat Care"},{"key":"bibr20-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2006.08.040"},{"key":"bibr21-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1177\/0269216308098798"},{"key":"bibr22-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbt075"},{"key":"bibr23-1049909115615568","doi-asserted-by":"publisher","DOI":"10.2190\/E2DY-42C7-7QP6-7052"},{"key":"bibr24-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1080\/074811801750257545"},{"key":"bibr25-1049909115615568","doi-asserted-by":"publisher","DOI":"10.12968\/ijpn.2004.10.12.17280"},{"key":"bibr26-1049909115615568","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2008.tb01590.x"},{"key":"bibr27-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1111\/1753-6405.12177"},{"key":"bibr28-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1177\/1049732305276687"},{"key":"bibr29-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1177\/001316446002000104"},{"key":"bibr30-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-6427.2010.00495.x"},{"key":"bibr31-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1080\/07481187.2011.553334"},{"key":"bibr32-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1177\/0269216315576262"},{"key":"bibr33-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123012"},{"key":"bibr34-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2012.0450"},{"key":"bibr35-1049909115615568","doi-asserted-by":"publisher","DOI":"10.12968\/ijpn.2013.19.6.282"},{"key":"bibr36-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2013.0339"},{"key":"bibr37-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-13-3"},{"key":"bibr38-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1177\/0269216311424953"},{"key":"bibr39-1049909115615568","doi-asserted-by":"publisher","DOI":"10.2190\/OM.55.3.c"},{"key":"bibr40-1049909115615568","volume-title":"3235.0 - Population by Age and Sex, Regions of Australia, 2013","author":"Australian Bureau of Statistics","year":"2014"},{"key":"bibr41-1049909115615568","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-936"}],"container-title":["American Journal of Hospice and Palliative Medicine\u00ae"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1049909115615568","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1049909115615568","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1049909115615568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:29:55Z","timestamp":1777368595000},"score":7.5691977,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1049909115615568"}},"subtitle":["Lessons Learnt From Bereaved Caregivers"],"issued":{"date-parts":[[2016,7,11]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1177\/1049909115615568"],"URL":"https:\/\/doi.org\/10.1177\/1049909115615568","ISSN":["1049-9091","1938-2715"],"issn-type":[{"value":"1049-9091","type":"print"},{"value":"1938-2715","type":"electronic"}],"published":{"date-parts":[[2016,7,11]]}},{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:46:27Z","timestamp":1777664787475,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,4,4]],"date-time":"2015-04-04T00:00:00Z","timestamp":1428105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Health Educ Behav"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Objective. To test the impact of a minimal, online planning intervention on physical activity in Australian office workers. Method. Employees were randomized to an implementation intention intervention ( n = 124) or health information control group ( n = 130). Measures of physical activity, past behavior, and motivation were taken at baseline and 6 weeks. Results. Analysis revealed both groups increased weekly physical activity sessions (intervention M = 1.12, control M = 0.78) at follow-up, but no significant difference was found between groups. Because the sample consisted of experienced exercisers, secondary analyses investigated differential effects for those who had lapsed over the previous year (nonmaintainers) and those who had maintained their previous level of activity (maintainers). For nonmaintainers, both planning and information provision successfully changed behavior, but only planning significantly increased physical activity in maintainers over the study. Conclusion. Different minimal intervention approaches may be useful for preventing long-term relapse and assisting people to improve regular exercise routines. The practical and theoretical implications are discussed.<\/jats:p>","DOI":"10.1177\/1090198115577374","type":"journal-article","created":{"date-parts":[[2015,4,4]],"date-time":"2015-04-04T20:28:23Z","timestamp":1428179303000},"page":"730-735","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Insights for Exercise Adherence From a Minimal Planning Intervention to Increase Physical Activity"],"prefix":"10.1177","volume":"42","author":[{"given":"Janine","family":"Chapman","sequence":"first","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia"},{"name":"Cancer Council SA, Eastwood, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Campbell","sequence":"additional","affiliation":[{"name":"The University of Adelaide, Adelaide, South Australia, Australia"},{"name":"Colmar Brunton Research, Parkside, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlene","family":"Wilson","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia"},{"name":"Cancer Council SA, Eastwood, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,4,4]]},"reference":[{"key":"bibr1-1090198115577374","volume-title":"National Health Survey 2007-2008","author":"Australian Bureau of Statistics"},{"key":"bibr2-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1080\/08870440802642148"},{"key":"bibr3-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5868-9-52"},{"key":"bibr4-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1037\/a0021974"},{"key":"bibr5-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.27.2.179"},{"key":"bibr6-1090198115577374","first-page":"287","volume-title":"The psychology of action: Linking cognition and motivation to behaviour","author":"Gollwitzer P. M.","year":"1996"},{"key":"bibr7-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.73.1.186"},{"key":"bibr8-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2601(06)38002-1"},{"key":"bibr9-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-119"},{"key":"bibr10-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1080\/02640410152475847"},{"key":"bibr11-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e3180616b27"},{"key":"bibr12-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1093\/heapro\/dar035"},{"key":"bibr13-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2004.10.014"},{"key":"bibr14-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1177\/1090198111417621"},{"key":"bibr15-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-011-9279-8"},{"key":"bibr16-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1037\/a0016939"},{"key":"bibr17-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1348\/135910702169420"},{"key":"bibr18-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1080\/08870440310001594493"},{"key":"bibr19-1090198115577374","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.026"},{"key":"bibr20-1090198115577374","volume-title":"World health statistics","author":"World Health Organization","year":"2011"}],"container-title":["Health Education & Behavior"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1090198115577374","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1090198115577374","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1090198115577374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:36:59Z","timestamp":1777448219000},"score":7.5691876,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1090198115577374"}},"issued":{"date-parts":[[2015,4,4]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1177\/1090198115577374"],"URL":"https:\/\/doi.org\/10.1177\/1090198115577374","ISSN":["1090-1981","1552-6127"],"issn-type":[{"value":"1090-1981","type":"print"},{"value":"1552-6127","type":"electronic"}],"published":{"date-parts":[[2015,4,4]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:31Z","timestamp":1753889791834,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,6,20]]},"abstract":"Introduction and Objective: The ReCET\u2122 System (endoscopic Re-Cellularization via Electroporation Therapy) uses pulsed electric field (PEF), to induce duodenal mucosal apoptotic-like cell death followed by regeneration. We evaluated the intervention energy dose on metabolic outcomes.<\/jats:p>\n Methods: REGENT-1 studied PEF therapy at three doses in T2D adults on 1-4 non-insulin agents. Group 1) Gen 1 catheter 600V, single treatment (n=12); Group 2) Gen 1 catheter, 600V, double treatment (n=18); and Group 3) Gen 2 catheter (increased treated surface area [TSA]), double treatment 750V (n=21). Primary endpoint: Serious adverse events (SAEs). Secondary endpoints included metabolic changes at 24 and 48 weeks.<\/jats:p>\n Results: One intervention related SAE occurred in 51 participants (age 52.9\u00b17.9 years, BMI 31.4\u00b13.5 kg\/m\u00b2, baseline HbA1c 8.7\u00b10.9%[72\u00b19mmol\/mol]). Other device\/procedure-related adverse events (76 events in 47\/51 participants) were mild and transient. Increased PEF dose (two applications, and higher voltage plus larger catheter diameter) correlated with metabolic improvements at 24 and 48 weeks. (Table 1)<\/jats:p>\n Conclusion: PEF-induced duodenal regeneration with the ReCET System resulted in improved metabolic outcomes that were dose-dependent. These promising findings suggest that further research is warranted.<\/jats:p>\n \n \n Disclosure<\/jats:title>\n D.N. O'Neal: None. A. Sartoretto: Research Support; Endogenex. Advisory Panel; Bariatek. Research Support; Erbe Elektromedizin GmbH. Consultant; Boston Scientific Corporation. Speaker's Bureau; Menarini. S. Chandran: None. R. Vaughan: None. B. Holt: None. A.J. Thompson: Other Relationship; Endogenex. G. Cameron: None. B. AbuDayyeh: Other Relationship; Endogenex. Consultant; Boston Scientific Corporation, Metronics, Olympus. R.E. Pratley: Consultant; AbbVie Inc. Stock\/Shareholder; Altanine, Inc. Consultant; Amgen Inc, AstraZeneca. Other Relationship; Bayer AG, Bayer Pharmaceuticals, Inc, Biomea Fusion. Consultant; Boehringer-Ingelheim. Other Relationship; Carmot Therapeutics, Inc, Corcept Therapeutics, Domp\u00e9, Eli Lilly and Company, Endogenex. Consultant; Endogenex. Other Relationship; Fractyl Health, Inc., Gasherbrum Bio, Inc. Consultant; Genprex, Getz Pharma, Hanmi Pharm. Co., Ltd, Intas Pharmaceuticals Ltd, Lexicon Pharmaceuticals, Inc, Lilly USA LLC. Speaker's Bureau; Lilly USA LLC. Other Relationship; Metavention, Novo Nordisk, Novo Nordisk. Speaker's Bureau; Novo Nordisk. Other Relationship; Pfizer Inc, Poxel SA. Consultant; Regeneron Pharmaceuticals. Other Relationship; Sanofi. Consultant; Scholar Rock. Other Relationship; Sun Pharmaceutical Industries Ltd. C.H. Sorli: Employee; Endogenex. E.I. Ekinci: Research Support; Amgen Inc, Novo Nordisk, Lilly Diabetes, AstraZeneca, Endogenex, Versanis. Advisory Panel; Lilly Diabetes, Novo Nordisk.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-880-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T06:55:56Z","timestamp":1749797756000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["880-P: Effects of Energy Dosing on Safety and Efficacy in an Open-Label Study of Endoscopic Pulsed Electric Field Induced Electroporation in Type 2 Diabetes (REGENT-1 Trial)"],"prefix":"10.2337","volume":"74","author":[{"given":"DAVID N.","family":"O'NEAL","sequence":"first","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Fitzroy, Victoria, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ADRIAN","family":"SARTORETTO","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Fitzroy, Victoria, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUJIEVVAN","family":"CHANDRAN","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Fitzroy, Victoria, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RHYS","family":"VAUGHAN","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Fitzroy, Victoria, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRONTE","family":"HOLT","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Fitzroy, Victoria, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALEXANDER J.","family":"THOMPSON","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Fitzroy, Victoria, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GEORGINA","family":"CAMERON","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Fitzroy, Victoria, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BARHAM","family":"ABUDAYYEH","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Fitzroy, Victoria, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD E.","family":"PRATLEY","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Fitzroy, Victoria, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTOPHER H.","family":"SORLI","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Fitzroy, Victoria, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELIF I.","family":"EKINCI","sequence":"additional","affiliation":[{"name":"Fitzroy, Australia, Double Bay, Australia, Melbourne, Australia, Heidelberg, Australia, Fitzroy, Victoria, Australia, Los Angeles, CA, Orlando, FL, Red Lodge, MT"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/880-P\/160117\/880-P-Effects-of-Energy-Dosing-on-Safety-and","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/880-P\/160117\/880-P-Effects-of-Energy-Dosing-on-Safety-and","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T16:58:56Z","timestamp":1750438736000},"score":7.569149,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/74\/Supplement_1\/880-P\/160117\/880-P-Effects-of-Energy-Dosing-on-Safety-and"}},"issued":{"date-parts":[[2025,6,20]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,6,20]]}},"URL":"https:\/\/doi.org\/10.2337\/db25-880-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2025,6,20]]},"article-number":"880-P"},{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T14:52:04Z","timestamp":1775141524714,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Prom J of Aust"],"published-print":{"date-parts":[[2025,4]]},"abstract":"ABSTRACT<\/jats:title>Issue Addressed<\/jats:title>Past research suggests that fathers are underrepresented in traditional parenting and child health promotion programs compared to mothers. One promising method to deliver support is a peer\u2010facilitated approach that enables fathers to connect with their peers. This model has been adopted by several community organisations in Australia. However, limited research evaluates the implementation and impact of these services.<\/jats:p><\/jats:sec>Methods<\/jats:title>This study conducted interviews with 10 Australian fathers who lead School Dads groups<\/jats:italic>\u2014a peer\u2010based model of support for Australian fathers delivered by one not\u2010for\u2010profit organisation. Using interpretative description methodology, we sought to understand how these leaders approached implementing School Dads Groups<\/jats:italic>, and their perception of how participation in these groups impacts their members.<\/jats:p><\/jats:sec>Results<\/jats:title>Key findings of the thematic analysis revealed that leaders felt the key goal and benefit of participating in a School Dads Group<\/jats:italic> is to build closer relationships between fathers and their children. While participants were committed to facilitating peer support, they also recognised potential barriers that prevent translating this into practice, including difficulties maintaining attendance.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The study's findings uncover the main motivations for peer facilitators, crucial for the expansion and success of father\u2010focused community\u2010based programs.<\/jats:p><\/jats:sec>So What?<\/jats:title>The findings suggest that school\u2010based, peer support programmes for fathers could be an effective medium for delivering health promotion, with the potential to positively influence fathers and children's well\u2010being.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hpja.70043","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:23:56Z","timestamp":1744331036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Experiences of Australian Fathers Who Lead School \u2018Dads Groups\u2019"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6972-2875","authenticated-orcid":false,"given":"Thomas","family":"Nevill","sequence":"first","affiliation":[{"name":"The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-8104","authenticated-orcid":false,"given":"Vincent O.","family":"Mancini","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia Perth Western Australia Australia"},{"name":"University of Western Australia Perth Western Australia Australia"},{"name":"The Fathering Project Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249707"},{"key":"e_1_2_10_3_1","unstructured":"P. Y.GoodwinandD. A.Garrett eds. \u201cWomen and Family Health: The Role of Mothers in Promoting Family and Child Health \u201d2017."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/13698575.2011.624179"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/107484002237514"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5172\/jfs.2012.18.2-3.165"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hpja.432"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/men0000320"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12280"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hpja.846"},{"key":"e_1_2_10_11_1","volume-title":"Promoting Children's Health: Integrating School, Family, and Community","author":"Power T. J.","year":"2003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0033786"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4324\/9781351329040-11"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jomf.12645"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1059840519873380"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192513X15622415"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2019.02405"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/15579883211024375"},{"issue":"5","key":"e_1_2_10_19_1","first-page":"680","article-title":"Unmasking Work\u2010Family Balance Barriers and Strategies Among Working Fathers in the Workplace","volume":"27","author":"Tanquerel S.","year":"2020","journal-title":"IDEAS Working Paper Series From RePEc"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3149\/fth.0903.291"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ap.12361"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.58464\/2168-670X.1007"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.5172\/jfs.2012.18.2-3.121"},{"issue":"1","key":"e_1_2_10_24_1","first-page":"1","article-title":"Father\u2010Inclusive Perinatal Parent Education Programs: A Systematic Review","volume":"142","author":"Lee J. Y.","year":"2018","journal-title":"Pediatrics (Evanston)"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/scs.12529"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1037\/men0000494"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10826-019-01383-y"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2016.09.002"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hpja.727"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3310\/phr03030"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638237.2017.1417559"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2017.06.008"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359105311435983"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1037\/men0000102"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1891\/J-PE-D-20-00015"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnn.2020.10.001"},{"key":"e_1_2_10_37_1","first-page":"257","volume-title":"Interpretive Description. Springer Texts in Education","author":"Okoko J. M.","year":"2023"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-S1-S13"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.4324\/9781315426259"},{"key":"e_1_2_10_40_1","volume-title":"Successful Qualitative Research: A Practical Guide for Beginners","author":"Braun V.","year":"2013"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2003.10.021"},{"issue":"2","key":"e_1_2_10_42_1","first-page":"301","article-title":"Systems Thinking and Complexity: Considerations for Health Promoting Schools","volume":"32","author":"Rosas S. R.","year":"2017","journal-title":"Health Promotion International"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/0305764X.2015.1069792"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/13229400.2023.2216668"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1921\/gpwk.v25i3.948"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnn.2017.04.001"},{"key":"e_1_2_10_47_1","first-page":"26","volume-title":"Social Capital and Men's Mental Health","author":"Conrad D.","year":"2018"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/1557988318772732"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijedudev.2014.11.008"},{"issue":"4","key":"e_1_2_10_50_1","first-page":"28","article-title":"Fathers and Parenting Programmes: Barriers and Best Practice","volume":"82","author":"Bayley J.","year":"2009","journal-title":"Community Practitioner"}],"container-title":["Health Promotion Journal of Australia"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hpja.70043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T02:25:32Z","timestamp":1745547932000},"score":7.5690618,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hpja.70043"}},"issued":{"date-parts":[[2025,4]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/hpja.70043"],"URL":"https:\/\/doi.org\/10.1002\/hpja.70043","archive":["Portico"],"ISSN":["1036-1073","2201-1617"],"issn-type":[{"value":"1036-1073","type":"print"},{"value":"2201-1617","type":"electronic"}],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70043"},{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:38:13Z","timestamp":1759937893824},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Rheumatol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"\n Objectives<\/jats:title>\n Quantification of work disability in patients with early rheumatoid arthritis (RA) receiving conventional DMARDs according to a treat-to-target strategy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This is a retrospective cohort analysis of RA patients who received combination conventional DMARDs, escalated to achieve DAS28(ESR) remission and completed an annual work and arthritis questionnaire. Random effect mixed modeling was used to assess associations between average hours worked per week (HWPW), and baseline prognostic factors. HWPW were compared with matched population averages. Cox proportional hazards modeling was employed to evaluate associations between permanent loss of employment and treatment response, disease and demographic factors.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Work data from 135 patients working at baseline and 137 working at any point followed for up to 14 years (range 1\u201314) were available for analysis. The mean age was 45 years, 70% were female, and 70% and 68% were seropositive for rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP), respectively. Men worked more hours than women; there was a highly significant association between working hours lost and increasing age (0.28 hours, P<\/jats:italic> = 0.04) and female gender (11.92 hours, P<\/jats:italic> < 0.001). HWPW were maintained over the study time comparable to the general population (loss of 0.78 vs. 0.24 HWPW). EULAR good responders at 6 months were more likely to be working at 10 years compared to those with moderate\/no response. Permanent loss of employment and baseline age were strongly associated for anti-CCP positive participants (P<\/jats:italic> = 0.04).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Treat-to-target combination conventional DMARD therapy maintains work capacity, particularly in good responders, comparable to the general population. Improving treatment response in moderate\/no responders early in disease may increase work retention.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/rhu.0000000000000506","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T13:24:04Z","timestamp":1489065844000},"page":"131-137","source":"Crossref","is-referenced-by-count":7,"title":["A Treat-to-Target Strategy Preserves Work Capacity in a Rheumatoid Arthritis Inception Cohort Treated With Combination Conventional DMARD Therapy"],"prefix":"10.1097","volume":"23","author":[{"given":"Mihir D.","family":"Wechalekar","sequence":"first","affiliation":[{"name":"From the *Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; \u2020Flinders University of South Australia, School of Medicine, Bedford Park, South Australia, Australia; \u2021Rheumatology Unit, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia; \u00a7University of Adelaide, Adelaide, South Australia, Australia; and \u2225Rheumatology Unit, Repatriation General Hospital, Daw Park, South Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Quinn","sequence":"additional","affiliation":[{"name":"From the *Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; \u2020Flinders University of South Australia, School of Medicine, Bedford Park, South Australia, Australia; \u2021Rheumatology Unit, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia; \u00a7University of Adelaide, Adelaide, South Australia, Australia; and \u2225Rheumatology Unit, Repatriation General Hospital, Daw Park, South Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Lester","sequence":"additional","affiliation":[{"name":"From the *Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; \u2020Flinders University of South Australia, School of Medicine, Bedford Park, South Australia, Australia; \u2021Rheumatology Unit, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia; \u00a7University of Adelaide, Adelaide, South Australia, Australia; and \u2225Rheumatology Unit, Repatriation General Hospital, Daw Park, South Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Metcalf","sequence":"additional","affiliation":[{"name":"From the *Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; \u2020Flinders University of South Australia, School of Medicine, Bedford Park, South Australia, Australia; \u2021Rheumatology Unit, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia; \u00a7University of Adelaide, Adelaide, South Australia, Australia; and \u2225Rheumatology Unit, Repatriation General Hospital, Daw Park, South Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ella","family":"Shanahan","sequence":"additional","affiliation":[{"name":"From the *Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; \u2020Flinders University of South Australia, School of Medicine, Bedford Park, South Australia, Australia; \u2021Rheumatology Unit, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia; \u00a7University of Adelaide, Adelaide, South Australia, Australia; and \u2225Rheumatology Unit, Repatriation General Hospital, Daw Park, South Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer G.","family":"Walker","sequence":"additional","affiliation":[{"name":"From the *Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; \u2020Flinders University of South Australia, School of Medicine, Bedford Park, South Australia, Australia; \u2021Rheumatology Unit, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia; \u00a7University of Adelaide, Adelaide, South Australia, Australia; and \u2225Rheumatology Unit, Repatriation General Hospital, Daw Park, South Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm D.","family":"Smith","sequence":"additional","affiliation":[{"name":"From the *Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; \u2020Flinders University of South Australia, School of Medicine, Bedford Park, South Australia, Australia; \u2021Rheumatology Unit, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia; \u00a7University of Adelaide, Adelaide, South Australia, Australia; and \u2225Rheumatology Unit, Repatriation General Hospital, Daw Park, South Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine L.","family":"Hill","sequence":"additional","affiliation":[{"name":"From the *Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; \u2020Flinders University of South Australia, School of Medicine, Bedford Park, South Australia, Australia; \u2021Rheumatology Unit, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia; \u00a7University of Adelaide, Adelaide, South Australia, Australia; and \u2225Rheumatology Unit, Repatriation General Hospital, Daw Park, South Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Michael","family":"Shanahan","sequence":"additional","affiliation":[{"name":"From the *Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; \u2020Flinders University of South Australia, School of Medicine, Bedford Park, South Australia, Australia; \u2021Rheumatology Unit, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia; \u00a7University of Adelaide, Adelaide, South Australia, Australia; and \u2225Rheumatology Unit, Repatriation General Hospital, Daw Park, South Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna M.","family":"Proudman","sequence":"additional","affiliation":[{"name":"From the *Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; \u2020Flinders University of South Australia, School of Medicine, Bedford Park, South Australia, Australia; \u2021Rheumatology Unit, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia; \u00a7University of Adelaide, Adelaide, South Australia, Australia; and \u2225Rheumatology Unit, Repatriation General Hospital, Daw Park, South Australia, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"bib1-20230927","first-page":"S71","article-title":"Work disability in early rheumatoid arthritis","volume":"21","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"bib2-20230927","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1093\/rheumatology\/39.12.1403","article-title":"The impact of rheumatoid arthritis on employment status in the early years of disease: a UK community based study","volume":"39","year":"2000","journal-title":"Rheumatology (Oxford)"},{"key":"bib3-20230927","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/art.1780300504","article-title":"The work dynamics of the person with rheumatoid arthritis","volume":"30","year":"1987","journal-title":"Arthritis Rheum"},{"key":"bib4-20230927","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/art.23538","article-title":"Contemporary prevalence and incidence of work disability associated with rheumatoid arthritis in the US","volume":"59","year":"2008","journal-title":"Arthritis Rheum"},{"key":"bib5-20230927","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/annrheumdis-2011-200701","article-title":"Decline in work disability caused by early rheumatoid arthritis: results from a nationwide Finnish register, 2000\u20138","volume":"72","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"bib6-20230927","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/occmed\/kqi171","article-title":"Systematic review of studies of productivity loss due to rheumatoid arthritis","volume":"56","year":"2006","journal-title":"Occup Med (Lond)"},{"key":"bib7-20230927","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1136\/ard.2003.020115","article-title":"Predictive factors of work disability in rheumatoid arthritis: a systematic literature review","volume":"63","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"bib8-20230927","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(04)16676-2","article-title":"Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial","volume":"364","year":"2004","journal-title":"Lancet"},{"key":"bib9-20230927","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1136\/ard.2007.071092","article-title":"Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial)","volume":"66","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"bib10-20230927","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1136\/ard.2007.076307","article-title":"Aggressive combination therapy with intra-articular glucocorticoid injections and conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis: second-year clinical and radiographic results from the CIMESTRA study","volume":"67","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"bib11-20230927","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1136\/ard.2004.030924","article-title":"Effectiveness of systematic monitoring of rheumatoid arthritis disease activity in daily practice: a multicentre, cluster randomised controlled trial","volume":"64","year":"2005","journal-title":"Ann Rheum 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development of work disability in early rheumatoid arthritis: a five-year randomized follow-up trial","volume":"50","year":"2004","journal-title":"Arthritis Rheum"},{"key":"bib15-20230927","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1001\/jamainternmed.2013.7801","article-title":"Biological vs. conventional combination treatment and work loss in early rheumatoid arthritis: a randomized trial","volume":"173","year":"2013","journal-title":"JAMA Intern Med"},{"key":"bib16-20230927","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","year":"1988","journal-title":"Arthritis Rheum"},{"key":"bib17-20230927","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against 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Insufficient maternal vitamin D (25(OH)D) has also been associated with increased disease risk for many diseases and adverse later life outcomes. The association between maternal and cord blood total 25(OH)D and LTL was examined in mother-child pairs from the HAPO Hong Kong Field Centre, including 815 offspring at age (mean\u00b1SD) 6.96 \u00b1 0.44 years. LTL was measured using real-time polymerase chain reaction and serum 25(OH)D2, 25(OH)D3 and 3-epi-25(OH)D3 were measured in maternal blood (at gestation 24-32 weeks) and cord blood by liquid chromatography-mass spectrometry. Children LTL at follow-up was significantly shorter in boys compared to girls (p&lt;0.001) at age 7. Childhood LTL was positively associated with insulin sensitivity according to the Matsuda index after sex and age adjustment (\u03b2\u00b1SE=0.038\u00b10.017, p=0.022). Multiple linear regression was used to evaluate the relationship between 25(OH)D levels and LTL, with covariate adjustments for child age, sex, body mass index (BMI), systolic blood pressure (SBP), exercise, gestational age, mode of delivery, and maternal age, SBP, parity, smoking, current parental DM status and pre-pregnancy BMI. Childhood LTL positively correlated with total maternal 25(OH)D concentrations (\u03b2\u00b1SE=0.003\u00b10.001, p=0.001), maternal D3 (\u03b2\u00b1SE=0.003\u00b10.001, p=0.002) and maternal D3 epimer (\u03b2\u00b1SE=0.138\u00b10.042, p&lt;0.001), and similar associations were noted for cord D3 epimer (\u03b2\u00b1SE=0.101\u00b10.045, p=0.024) and cord total 25(OH)D (\u03b2\u00b1SE=0.1\u00b10.05, p=0.048), even after covariates adjustments. Our findings suggest 25(OH)D, D3 and D3 epimer both in utero and at birth may impact on childhood LTLs, highlighting a potential link between maternal vitamin D and biological aging.<\/jats:p>\n \n Disclosure<\/jats:title>\n K. Wong: None. B. E. Metzger: None. W. Lowe: None. W. H. Tam: None. R. C. Ma: Other Relationship; Self; AstraZeneca, Medtronic, Research Support; Self; AstraZeneca, Bayer Healthcare Pharmaceuticals Inc., Novo Nordisk, Pfizer Inc., Sanofi-Aventis, Tricida, Inc. F. Cheng: None. D. Mao: None. C. K. P. Lim: Stock\/Shareholder; Self; GemVCare Ltd. R. Wang: None. C. H. Tam: None. M. A. Joglekar: None. A. A. Hardikar: None. A. Jenkins: Advisory Panel; Self; Abbott Diabetes, Sanofi-Aventis, Other Relationship; Self; Amgen Inc., Research Support; Self; Abbott, International Diabetes Federation, JDRF, Medtronic, Mylan N. V.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db21-275-or","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T22:14:53Z","timestamp":1624572893000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["275-OR: Maternal Vitamin D Levels during Pregnancy Is Associated with Childhood Telomere Length: Analysis from a Longitudinal Mother-Child Cohort"],"prefix":"10.2337","volume":"70","author":[{"given":"KWUN KIU","family":"WONG","sequence":"first","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Chicago, IL, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FEIFEI","family":"CHENG","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Chicago, IL, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DI","family":"MAO","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Chicago, IL, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CADMON K.P.","family":"LIM","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Chicago, IL, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RONALD","family":"WANG","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Chicago, IL, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CLAUDIA H.","family":"TAM","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Chicago, IL, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MUGDHA A.","family":"JOGLEKAR","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Chicago, IL, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANANDWARDHAN A.","family":"HARDIKAR","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Chicago, IL, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALICIA","family":"JENKINS","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Chicago, IL, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BOYD E.","family":"METZGER","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Chicago, IL, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WILLIAM","family":"LOWE","sequence":"additional","affiliation":[{"name":"Campbelltown, Australia, Sydney, Australia, Chicago, IL, Hong 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/275-OR\/139863\/275-OR-Maternal-Vitamin-D-Levels-during-Pregnancy","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/275-OR\/139863\/275-OR-Maternal-Vitamin-D-Levels-during-Pregnancy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T11:36:54Z","timestamp":1647171414000},"score":7.5688868,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/70\/Supplement_1\/275-OR\/139863\/275-OR-Maternal-Vitamin-D-Levels-during-Pregnancy"}},"issued":{"date-parts":[[2021,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db21-275-or","ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"published":{"date-parts":[[2021,6,1]]},"article-number":"275-OR"},{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:29:36Z","timestamp":1788956976735,"version":"build-2803163510"},"reference-count":93,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2021,11]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>Weight\u2010biased attitudes and views held by health care professionals can have a negative impact on the patient\u2010provider relationship and the provision of care, but studies have found mixed results about the extent and nature of bias, which warrants a review of the evidence.<\/jats:p><\/jats:sec>Methods<\/jats:title>A systematic review and random\u2010effects meta\u2010analysis were conducted by including studies up to January 12, 2021.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 41 studies met inclusion criteria, with 17 studies providing sufficient data to be meta\u2010analyzed. A moderate pooled effect (standardized mean difference = 0.66; 95% CI: 0.37\u20100.96) showed that health care professionals demonstrate implicit weight bias. Health care professionals also report explicit weight bias on the Fat Phobia Scale, Antifat Attitudes Scale, and Attitudes Towards Obese Persons Scale. Findings show that medical doctors, nurses, dietitians, psychologists, physiotherapists, occupational therapists, speech pathologists, podiatrists, and exercise physiologists hold implicit and\/or explicit weight\u2010biased attitudes toward people with obesity. A total of 27 different outcomes were used to measure weight bias, and the overall quality of evidence was rated as very low.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Future research needs to adopt more robust research methods to improve the assessment of weight bias and to inform future interventions to address weight bias among health care professionals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.23266","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T02:57:36Z","timestamp":1630983456000},"page":"1802-1812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":260,"title":["Weight bias among health care professionals: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8772-8226","authenticated-orcid":false,"given":"Blake J.","family":"Lawrence","sequence":"first","affiliation":[{"name":"School of Population 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Assessing the capacity for a fault to seal or leak can be difficult to determine, particularly where well constraint is lacking. In the frontier basin, in a marine setting, seismic velocities may be the only data available. However, useful constraints on a faults sealing capacity can be extracted from this data alone. This study investigates the robustness of a number of empirical relations that can assist in extracting useful constraints from seismic velocities and amplitudes. Information on maximum and minimum stress magnitudes and pore pressures can be calculated and combined with basic fault architecture analysis, to place practical constraints on fault risk. A study area on the Rankin Trend, North West Shelf of Australia, found good correlation between well-based and seismic velocity-based pore pressures and stress magnitudes allowing a Coulomb Failure Function to be calculated. Faults separating the Rankin 1 well block from the Dockrell\/Keast Field, were shown to be within a stable stress regime. Well data for this area confirms a SHmax orientation of approximately 110\u00b0 N +\/- 10\u00b0 indicating that steeply dipping faults striking within 20\u00b0 of this direction may be at high risk of failure within the neotectonic setting, where stress magnitudes, pore pressures, and fault geometry predicate fault slip.<\/jats:p>","DOI":"10.1190\/ice2015-2160874","type":"proceedings-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T14:10:38Z","timestamp":1458223838000},"page":"212-212","source":"Crossref","is-referenced-by-count":0,"title":["Constraining Fault Seal Risk Using Seismic Velocities and Well Data"],"prefix":"10.1190","volume":"1","author":[{"given":"Tobias","family":"Colson*","sequence":"additional","affiliation":[{"name":"1Geology, University of Western Australia, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Boterhoven","sequence":"additional","affiliation":[{"name":"2Exploration, BP Developments Australia, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myra","family":"Keep","sequence":"additional","affiliation":[{"name":"3Geology, University of Western Australia, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Castillo","sequence":"additional","affiliation":[{"name":"4Insight Geomechanics, Perth, Western Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"186","published-online":{"date-parts":[[2015,9,16]]},"event":{"name":"International Conference and Exhibition, Melbourne, Australia 13-16 September 2015","location":"Melbourne, Australia","acronym":"icemelbourne2015","start":{"date-parts":[[2015,9,13]]},"end":{"date-parts":[[2015,9,16]]}},"container-title":["Global Meeting Abstracts","International Conference and Exhibition, Melbourne, Australia 13-16 September 2015"],"link":[{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/212\/713684","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/212\/713684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:28:32Z","timestamp":1787243312000},"score":7.5683527,"resource":{"primary":{"URL":"https:\/\/pubs.geoscienceworld.org\/ice\/proceedings\/icemelbourne2015\/1\/212\/713684"}},"issued":{"date-parts":[[2015,9,16]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1190\/ice2015-2160874","ISSN":["2159-6832"],"issn-type":[{"value":"2159-6832","type":"electronic"}],"published":{"date-parts":[[2015,9,16]]}},{"indexed":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T05:41:19Z","timestamp":1655876479520},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"16_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2020,8,15]]},"abstract":"Abstract<\/jats:title>\n Objective: Spontaneous neo-antigen specific immune responses are rare in animals and humans. Our AB1 model, one of the few induced by a natural human carcinogen, has several. Given that current immunotherapies rely on unleashing responses to existing tumour neo-antigens, we evaluated the capacity of such responses to inform subsequent therapies, determining if these responses are:<\/jats:p>\n a) more sensitive than imaging to detect tumor recurrence after surgical resection<\/jats:p>\n b) able to predict responses to immune checkpoint blockade (ICPB) therapy<\/jats:p>\n c) able to provide evidence of the immunogenicity of chemotherapy.<\/jats:p>\n Methods: To examine this, we interrogated the immune response to tumour neo-antigens in BALB\/c mice bearing the AB1-HA tumor model.AB1-HA whole exome sequencing and RNAseq data were analysed and the MHC-I binding affinity of mutated sequences were predicted and expression confirmed with RNA-seq data. A total of 180 neo-antigens were screened, in addition to the responses to the known neo-antigens UNC45a and UQCRC2, spontaneous immune responses to two novel neo-antigens, VMN2R67 and ELP2 were found in tumour bearing mice. a) To determine if responses to these neo-antigens detected post-resection tumor recurrence tumours were surgically resected then growth of IV luciferase transfected cells determined sequentially by an In Vivo Imaging System (IVIS) and imaged for peak bioluminescence in a Lumina II Imager (Figure), PET-CT (IV 15-FDG at 7-15MBq). For neo-antigen specific T cell detection, IFNg ELISPOT assays were performed. b) To determine if pre-treatment neo-antigen responses are able to predict responses to ICPB, we utilised a version of the dual-tumor model developed by Lesterhuis et al, enabling pre-treatment neo-antigen responses to ICPB blockade (anti-CTLA-4 + anti-GITR) compared in subsequent responders versus non-responders.<\/jats:p>\n c) To determine if a known immunogenic chemotherapy (gemcitabine) could boost the efficacy of vaccines designed based on spontaneous neo-antigen reactivity, we treated tumour bearing mice with gemcitabine \u00b1 a vaccine containing the neoantigen peptides Unc45a, Uq2, Vmn2r67, and Elp2 with Poly I:C.<\/jats:p>\n Results: a) A combination of 3 neo-antigen specific T cell responses detected metastases detection prior to IVIS or PET-CT (86\u00b111 SFU\/105 cells for the recurrence group compared to 17\u00b15 SFU\/105 cells in the non-recurrence group, p&lt;0.0001).b) Pre-treatment dLN UNC45a response was higher in the responders (24 \u00b1 14 SFU\/105 vs 5 \u00b1 2 SFU\/105, p = 0.0004). Thus pretreatment responses to some neo-antigens could strongly predict response to ICPB therapy.c)Gemcitabine + vaccine delayed tumour growth compared to either treatment or adjuvant alone (p&lt;0.05).<\/jats:p>\n Conclusions: Neo-antigen specific T cell responses increases sensitivity of recurrence\/metastasis detection, predict ICPB therapy outcome and inform vaccine design for synergy with immunogenic chemotherapy.<\/jats:p>\n Citation Format: Bruce W. Robinson, Vanessa Fear, Catherine Forbes, Shaokang Ma, Jonathan Chee, Sam Neeve, Scott Fisher, Ian Dick, Anna Nowak, Nandini Makwana, Jessica Boulter, Jenette Creaney, Alec Redwood. Neo-antigen specific T cell responses can inform cancer therapy [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. 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The main modifiable risk factors for child obesity are unhealthy eating and low levels of physical activity, both influenced by aspects of the built environment. Coordinated government policy across jurisdictions, developed using strong research evidence, can enable built environments that better support healthy lifestyles. This study reviewed current Australian and Western Australian government policies to understand if and how they address the impact of the built environment on child obesity, physical activity, sedentary behavior, and diet. Current government policy documents related to the built environment and child health were analyzed using the Comprehensive Analysis of Policy on Physical Activity framework. Ten Australian and 31 Western Australian government policy documents were identified. Most referred to the role of the built environment in supporting physical activity. Very few policies mentioned the built environment's role in reducing sedentary behaviors, supporting healthy eating, and addressing obesity. Few recognized the needs of children, and none mentioned children in policy development. Future government policy development should include the voices of children and child\u2010specific built environment features. 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It has an aggressive clinical presentation and poor prognosis. The sonographic findings in 41 patients with a clinical diagnosis of IBC<\/jats:styled-content> and biopsy\u2010proven breast malignancy are presented in this study. The most common finding was the presence of skin thickening (92%). Multiple small anechoic spaces within the dermis, correlating with the presence of dermal lymphatic invasion by tumour emboli on histopathology were noted in approximately one\u2010third of cases. Other sonographic findings included single or multiple masses, parenchymal oedema, axillary lymphadenopathy, echogenic foci consistent with microcalcifications and increased vascularity.<\/jats:p>","DOI":"10.1111\/1754-9485.12418","type":"journal-article","created":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T02:29:16Z","timestamp":1449109756000},"page":"83-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Review of ultrasound appearance in inflammatory breast cancer: A pictorial essay"],"prefix":"10.1111","volume":"60","author":[{"given":"Dilupani Y","family":"Abeywardhana","sequence":"first","affiliation":[{"name":"Radiology Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinicius C","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Radiology Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepthi","family":"Dissanayake","sequence":"additional","affiliation":[{"name":"Radiology Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1481-1141","authenticated-orcid":false,"given":"Donna","family":"Taylor","sequence":"additional","affiliation":[{"name":"Radiology Royal Perth Hospital Perth Western Australia Australia"},{"name":"School of Surgery University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecily","family":"Metcalf","sequence":"additional","affiliation":[{"name":"PathWest Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christobel","family":"Saunders","sequence":"additional","affiliation":[{"name":"School of Surgery University of Western Australia Perth Western Australia Australia"},{"name":"Department of Surgery Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Wylie","sequence":"additional","affiliation":[{"name":"Radiology Royal Perth Hospital Perth Western Australia Australia"},{"name":"School of Surgery University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,2]]},"reference":[{"volume-title":"FS. ACR BI\u2010RADS","year":"2003","author":"Bassett LW","key":"e_1_2_7_2_1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-007-9671-z"},{"key":"e_1_2_7_4_1","unstructured":"KrishnamurthyS.Inflammatory Breast Cancer Pathology. The University of Texas MD Anderson Cancer Center Professional Oncology Education Web site.[Internet].2014."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq345"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-7071(04)00050-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2233010198"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ro.2011.04.003"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1754-9485.12418","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.12418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T03:55:54Z","timestamp":1696478154000},"score":7.5679,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.12418"}},"issued":{"date-parts":[[2015,12,2]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/1754-9485.12418"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.12418","archive":["Portico"],"ISSN":["1754-9477","1754-9485"],"issn-type":[{"type":"print","value":"1754-9477"},{"type":"electronic","value":"1754-9485"}],"published":{"date-parts":[[2015,12,2]]},"assertion":[{"value":"2015-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:07:39Z","timestamp":1784326059793,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2019,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Oral leukoplakia (OL) is the most common oral potentially malignant disorder, yet despite its chronic and potentially disabling nature, the literature concerning impacts of OL on quality of life (QoL) is limited. This study aimed to evaluate QoL in subjects with OL compared to controls using QoL questionnaires.<\/jats:p><\/jats:sec>Methods<\/jats:title>Fifty individuals with OL and 50 controls matched for age, gender, smoking, and alcohol use were administered the Short Generic Health Questionnaire (SF\u201012) and the discipline\u2010specific Oral Potentially Malignant Disorder Questionnaire (OPMDQ). Responses were compared between the two groups.<\/jats:p><\/jats:sec>Results<\/jats:title>Subjects with OL reported poorer QoL scores compared to controls in two domains \u201cRole limitations due to physical problems\u201d and \u201cPain\u201d of the SF\u201012 questionnaire, and in two domains \u201cDifficulty with diagnosis\u201d and \u201cEffect of treatment on daily life\u201d and in the overall scores of the OPMDQ. Females reported poorer QoL in the overall OPMD QoL score and in the domains of \u201cPhysical and function limitation\u201d and \u201cPsychological and social well\u2010being,\u201d while older individuals in the domains of \u201cPhysical and function limitation\u201d and \u201cEffect of treatment on daily life.\u201d Non\u2010alcohol drinkers and subjects with dysplastic or non\u2010homogeneous OLs also reported poorer QoL scores.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Quality of life assessments provide useful insight into the impact of OL on an individual's life and opportunity to improve clinical care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12897","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T08:07:12Z","timestamp":1559894832000},"page":"574-580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Quality of life in patients with oral leukoplakia"],"prefix":"10.1111","volume":"48","author":[{"given":"Xin","family":"Min Ang","sequence":"first","affiliation":[{"name":"UWA Dental School University of Western Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Chi Khang Au","sequence":"additional","affiliation":[{"name":"UWA Dental School University of Western Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Kwok","sequence":"additional","affiliation":[{"name":"UWA Dental School University of Western Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka","family":"Yeon Park","sequence":"additional","affiliation":[{"name":"UWA Dental School University of Western Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5951-8280","authenticated-orcid":false,"given":"Omar","family":"Kujan","sequence":"additional","affiliation":[{"name":"UWA Dental School University of Western Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5301-4148","authenticated-orcid":false,"given":"Agnieszka M.","family":"Frydrych","sequence":"additional","affiliation":[{"name":"UWA Dental School University of Western Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-6204","authenticated-orcid":false,"given":"Camile S.","family":"Farah","sequence":"additional","affiliation":[{"name":"UWA Dental School University of Western Australia Nedlands Western Australia Australia"},{"name":"Australian Centre for Oral Oncology Research & Education Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-010-0157-3"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"6","article-title":"Oral potentially malignant disorders: an overview of more than 20 entities","volume":"8","author":"Mortazavi H","year":"2014","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12148"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12368"},{"issue":"8","key":"e_1_2_7_6_1","first-page":"692","article-title":"Living in limbo: ethics and experience in a conversation about persistent oral lesions","volume":"130","author":"Flaitz CM","year":"2013","journal-title":"Tex dent 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differences in determinants and consequences of health and illness","volume":"25","author":"Vlassoff C","year":"2007","journal-title":"J Health Popul Nutr"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12339"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1922\/IDJ_2532Warnakulasuriya24"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.01.003"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2017.12.011"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0503(77)80079-9"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196712)20:12<2189::AID-CNCR2820201218>3.0.CO;2-M"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.04.002"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-5182(89)80085-X"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/208519"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130301400105"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)80007-9"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840201)53:3<563::AID-CNCR2820530332>3.0.CO;2-F"}],"container-title":["Journal of Oral Pathology & Medicine"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12897","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12897","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.12897","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T06:26:03Z","timestamp":1694327163000},"score":7.5679,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12897"}},"issued":{"date-parts":[[2019,6,26]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/jop.12897"],"URL":"https:\/\/doi.org\/10.1111\/jop.12897","archive":["Portico"],"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"published":{"date-parts":[[2019,6,26]]},"assertion":[{"value":"2019-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:51:02Z","timestamp":1785484262455,"version":"3.56.0"},"reference-count":71,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2023,11]]},"abstract":"Objective<\/jats:title>Methotrexate (MTX) is effective in controlling disease activity in rheumatoid arthritis (RA). Parenteral MTX may have benefits over oral MTX, but it is rarely used in practice. To better understand this low usage rate, it is necessary to explore the barriers and enablers of therapy from the perspective of RA patients. The objectives of this scoping review were to describe RA patients\u2019 perspectives on the barriers and enablers in the use of parenteral MTX and to identify the research gaps in this field.<\/jats:p><\/jats:sec>Methods<\/jats:title>The search was performed in Medline, Embase, Scopus, and Cochrane Library from inception to May 2021. Data synthesis was conducted using the Theoretical Framework of Acceptability. This scoping review included any type of study that explored the use of parenteral MTX by adult RA patients from the patients\u2019 perspective, written in English.<\/jats:p><\/jats:sec>Results<\/jats:title>Fifteen studies were included; findings related to the constructs \u201caffective attitude,\u201d \u201cburden,\u201d \u201cintervention coherence,\u201d and \u201cself\u2010efficacy\u201d were explored the most, while some were rarely (\u201copportunity cost\u201d and \u201cperceived effectiveness\u201d) or not (\u201cethicality\u201d) reported. RA patients were generally satisfied with MTX injections (\u201caffective attitude\u201d). From the burden construct, the requirement for dexterity for administering MTX by injection was considered a barrier, whereas the lack of significant pain from MTX injection was considered an enabler.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The findings suggested that patients generally preferred parenteral MTX formulations with attributes that facilitate self\u2010administration. However, much of the identified research focused on prefilled pen devices, and significant gaps were identified, such as a lack of qualitative research.<\/jats:p>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.25141","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T03:59:51Z","timestamp":1682999991000},"page":"2306-2315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Barriers and Enablers in the Use of Parenteral Methotrexate in Rheumatoid Arthritis Patients: A Scoping Review"],"prefix":"10.1002","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3660-6496","authenticated-orcid":false,"given":"Jiun Ming","family":"Tan","sequence":"first","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1405-999X","authenticated-orcid":false,"given":"Emily","family":"Reeve","sequence":"additional","affiliation":[{"name":"Monash University, Parkville, Victoria, Australia, and University of South Australia Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4527-9872","authenticated-orcid":false,"given":"Lauren","family":"Fraser","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3046-9884","authenticated-orcid":false,"given":"Susanna M.","family":"Proudman","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital and University of Adelaide Adelaide South Australia 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While proponents must demonstrate safe pressure limits to assure containment, far-field pressure effects resulting from multiple simultaneous CO2 storage operations could impact storage capacity, injectivity, plume migration pathways, hydrocarbon accumulations, monitoring strategies and regulatory considerations. To quantify these regional effects, we completed an integrated, multiple injection site assessment of the K20 sequence in the Barrow\u2013Dampier sub-basin. Five storage projects were located within the model domain, each supported by six wells injecting 1\u00a0MtCO2\/year\/well for 30\u00a0years. Boundary conditions ranged from closed to finite-aquifer support (Carter\u2013Tracy r-ratios 1.5\u201310) and simulations examined isolated, simultaneous and staggered start-ups, and scenarios with\/without a nearby gas field. Under closed boundary conditions, 514 MtCO2 was stored over 30\u00a0years, versus ~924\u00a0Mt if sites were assessed in isolation (~185\u00a0Mt\/site), indicating that single-site assessment can overestimate dynamic capacity. With finite external aquifer support, CO2 storage totals increased to 591 Mt (r\u00a0=\u00a01.5), 861 Mt (r\u00a0=\u00a03) and ~924\u00a0Mt (r\u00a0\u2265\u00a05); for r\u00a0\u2265\u00a05, design rates were sustained, and per-site storage converged to ~185\u00a0Mt. Plume monitoring footprints were sensitive to boundary conditions and were consistently smaller under multi-site than isolated modelling. Project sequencing mattered where aquifer support was limited (early-mover advantage), and coexistence with hydrocarbons showed mixed effects: storage capacity gains, but residual hydrocarbon trapping. These results underscore the importance of integrated regional modelling to yield realistic capacity\/injectivity estimates, defensible monitoring footprints and reduced-risk coexistence with petroleum operations.<\/jats:p>","DOI":"10.1071\/ep25180","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:53Z","timestamp":1778716853000},"source":"Crossref","is-referenced-by-count":0,"title":["Modelling the impacts of multiple large-scale CO2 storage projects within one region: lessons for operations and regulation"],"prefix":"10.1071","volume":"66","author":[{"given":"Mojtaba","family":"Seyyedi","sequence":"first","affiliation":[{"name":"AGlobal CCS Institute, Melbourne, Vic, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duy","family":"Nguyen","sequence":"additional","affiliation":[{"name":"BGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Consoli","sequence":"additional","affiliation":[{"name":"AGlobal CCS Institute, Melbourne, Vic, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Kalinowski","sequence":"additional","affiliation":[{"name":"BGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merrie-Ellen","family":"Gunning","sequence":"additional","affiliation":[{"name":"BGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuqi","family":"Wang","sequence":"additional","affiliation":[{"name":"BGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Feitz","sequence":"additional","affiliation":[{"name":"BGeoscience Australia, Canberra, ACT, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"2026051320004742800_R1","unstructured":"Australian Government (2024a) Guideline: Offshore Greenhouse Gas Injection Licences. 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Current treatment guidelines rarely specify when to stop medicines, leading to medicines often being continued indefinitely without a clear deprescribing plan. While deprescribing guidelines exist for some medicine classes, limited guidance is a major barrier to deprescribing. These new guidelines address this gap by providing structured recommendations that complement more detailed drug\u2010specific deprescribing guidance, disease\u2010specific therapeutic guidelines and non\u2010pharmacological management resources. These guidelines were developed by a team of 72 experts, including consumer representatives, and were further shaped by feedback from public consultation and independent reviewers.<\/jats:p>\n <\/jats:sec>\n \n Main Recommendations<\/jats:title>\n The guidelines are intended for all healthcare professionals involved in prescribing, dispensing or administering medicines to older people. The guidelines specifically address polypharmacy and medicines commonly dispensed for regular use in people aged \u2265\u200965\u2009years, as well as other medicines where there is evidence to consider deprescribing in this cohort. The guidelines provide 185 consensus\u2010based recommendations and 70 good practice statements, covering both specific medicine categories and general deprescribing principles. The guidelines are structured into four areas: (1) when to deprescribe; (2) ongoing treatment needs; (3) how to deprescribe; and (4) monitoring requirements.<\/jats:p>\n <\/jats:sec>\n \n Changes in Care as a Result of the Guideline<\/jats:title>\n \n This guideline emphasises deprescribing as an integral part of the prescribing continuum. Applying a deprescribing approach encourages prescribers to consider the ongoing need for a medicine each time a prescription is re\u2010issued, to balance benefits and harms as they evolve over time, and to ensure treatment decisions reflect an individual's goals through shared decision\u2010making. The guideline was developed based on currently available evidence for deprescribing and expert multidisciplinary and consumer input. It supports health professionals in reviewing regular medicines, minimising harm and planning ongoing treatment or monitoring. The detailed guideline is available at\n https:\/\/deprescribing.com<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.5694\/mja2.70174","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:34:31Z","timestamp":1775543671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Deprescribing in Older People: A Clinical Practice Guideline Summary"],"prefix":"10.5694","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3851-179X","authenticated-orcid":false,"given":"Hui Wen","family":"Quek","sequence":"first","affiliation":[{"name":"Centre for Optimisation of Medicines The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xisco","family":"Reus Perello","sequence":"additional","affiliation":[{"name":"Centre for Optimisation of Medicines The University of Western Australia Perth Western 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The aim of this study was to compare biochemical timing of secretory activation between women who had a vaginal (V) or Caesarean birth with pethidine\u2010PCEA (CBP). Several milk samples were collected daily from 36 mothers (17 V, 19 CBP) for the first 265\u2009h post\u2010partum. Protein and lactose concentrations and Na+<\/jats:sup> and K+<\/jats:sup> ion levels were measured. Samples were assigned to three time periods: 0\u201372, >72\u2013165 and >165\u2013265\u2009h post\u2010partum for statistical analyses. Data were analyzed using linear mixed effect models. In the first 72\u2009h post\u2010partum, the mean difference in lactose concentration was 5\u2009gL\u22121<\/jats:sup> higher in group V (P<\/jats:italic>\u2009<\u20090.05). From >72\u2013165\u2009h post\u2010partum, protein and Na+<\/jats:sup> concentrations were lower in group V (P<\/jats:italic>\u2009=\u20090.05, P<\/jats:italic>\u2009=\u20090.02), and K+<\/jats:sup> levels were higher in group V (P<\/jats:italic>\u2009<\u20090.001). From >165\u2013265\u2009h post\u2010partum, there were no significant differences between the groups. Biochemically, secretory activation had occurred by 72\u2009h post\u2010partum in both groups. There were greater variations in measured biochemical components observed within group CBP initially. However, by 165\u2009h post\u2010partum, there were no differences in the biochemical components between the groups. This suggests that effects of pethidine\u2010PCEA are diminished by 72\u2009h post\u2010partum and undetected by 165\u2009h.<\/jats:p>","DOI":"10.1111\/mcn.12275","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T09:11:54Z","timestamp":1459761114000},"source":"Crossref","is-referenced-by-count":7,"title":["Changes in milk composition associated with pethidine\u2010PCEA usage after Caesarean section"],"prefix":"10.1111","volume":"13","author":[{"given":"Wan Jun","family":"Tie","sequence":"first","affiliation":[{"name":"School of Chemistry and Biochemistry University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazel","family":"Gardner","sequence":"additional","affiliation":[{"name":"School of Chemistry and Biochemistry University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching Tat","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Chemistry and Biochemistry University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Rachel","family":"Hepworth","sequence":"additional","affiliation":[{"name":"School of Chemistry and Biochemistry University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasir","family":"Al\u2010Tamimi","sequence":"additional","affiliation":[{"name":"Joondalup Health Campus Joondalup Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael James","family":"Paech","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter 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However, one major complication necessitating revision surgery is osteolysis causing aseptic loosening of the prosthesis. JAK-STAT has been demonstrated to influence bone metabolism and can be regulated by microRNA (miRNA).<\/jats:p>Adult patients with osteolysis or aseptic loosening undergoing revision HKA were recruited. Age and gender matched patients undergoing primary hip or knee arthroplasty were our controls. Samples of bone, tissue and blood were collected and RNA isolation was performed. The best quality samples were used for RNA-sequencing. Data analysis was performed using RStudio and Galaxy to identify differentially expressed genes. Western blotting of IL6 was used to confirm protein expression.<\/jats:p>Five circulating miRNA were identified which had 10 differentially expressed genes in bone and 11 differentially expressed genes in tissue related to the JAK-STAT pathway. IL6 in bone and EpoR in bone were highly significant and IL6 in tissue, MPL in bone, SOCS3 in tissue, JAK3 in bone and SPRED1 in bone were borderline significant. Western blot results demonstrated up-expression of IL6 in bone tissue of revision patients.<\/jats:p>Periprosthetic osteolysis and aseptic loosening can be attributed to miRNA regulation of the JAK-STAT pathway in osteoblasts and osteoclasts, leading to increased bone resorption. These findings can be used for further experiments to determine utility in the clinical setting for identifying diagnostic markers or therapeutic targets.<\/jats:p>","DOI":"10.1302\/1358-992x.2023.3.112","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T15:59:15Z","timestamp":1677167955000},"page":"112-112","update-policy":"http:\/\/dx.doi.org\/10.1302\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["MICRORNA ASSOCIATED WITH PERIPROSTHETIC OSTEOLOYSIS VIA JAK-STAT PATHWAY"],"prefix":"10.1302","volume":"105-B","author":[{"given":"Y.","family":"Deng","sequence":"first","affiliation":[{"name":"Canberra Hospital, ACT, Australia"},{"name":"Australia National University, ACT, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Canberra Hospital, ACT, Australia"},{"name":"Australia National University, ACT, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Smith","sequence":"additional","affiliation":[{"name":"Canberra Hospital, ACT, Australia"},{"name":"Australia National University, ACT, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Li","sequence":"additional","affiliation":[{"name":"Canberra Hospital, ACT, Australia"},{"name":"Australia National University, ACT, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"42","container-title":["Orthopaedic Proceedings"],"language":"en","link":[{"URL":"https:\/\/boneandjoint.org.uk\/doi\/10.1302\/1358-992X.2023.3.112\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/boneandjoint.org.uk\/doi\/10.1302\/1358-992X.2023.3.112\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/boneandjoint.org.uk\/doi\/pdf\/10.1302\/1358-992X.2023.3.112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T15:59:16Z","timestamp":1677167956000},"score":7.5670524,"resource":{"primary":{"URL":"https:\/\/boneandjoint.org.uk\/doi\/10.1302\/1358-992X.2023.3.112"}},"issued":{"date-parts":[[2023,2]]},"references-count":0,"journal-issue":{"issue":"SUPP_3","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1302\/1358-992X.2023.3.112"],"URL":"https:\/\/doi.org\/10.1302\/1358-992x.2023.3.112","ISSN":["1358-992X","2049-4416"],"issn-type":[{"value":"1358-992X","type":"print"},{"value":"2049-4416","type":"electronic"}],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"2023-2-","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:23:05Z","timestamp":1698124985072},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2023,10,23]]},"abstract":"Abstract<\/jats:title>\n Watchkeeping schedules expose workers to sleep and wake opportunities which are not at biologically ideal times, thus impacting sleep quantity and quality. This study investigated the impact of different watchkeeping schedules on sleep. N=29 healthy participants (16F; aged 18-34y) took part in a 10-day laboratory study. Participants were allocated to one of four schedules; 8h-on\/8h-off\/4h-on\/4h-off (day-sleep 09:30-16:00; n=8; Condition A), 6h-on\/6h-off (day-sleep 08:30h-12:30, nap 21:30-00:00; n=7; Condition B), and 4h-on\/4h-on-call\/4h-off\/4h-on\/8h-off (evening-sleep 18:00-00:30; n=7; Condition C; or night-sleep 01:30h-08:00; n=7; Condition D). Participants had 8h time in bed (TIB) for sleep at baseline and recovery. Every 24h during the schedule, participants received a 6.5h TIB. Sleep was measured using standard polysomnography and scored by a trained sleep technician. Linear mixed models found that Condition D (night sleep) had significantly longer total sleep time (TST) than Condition B (p=.003; split sleep). Participants obtained significantly less TST on Day 2 compared to remaining experimental days (Day 3 to Day 8; p&lt;.05). Sleep onset latency was longer on Day 8, than Days 2 and 3 (p&lt;.01). Time spent in REM sleep was shorter on Days 2 and 3 than any other days (p&lt;.05). There were no differences in sleep stages between conditions, except for TST. The split sleep in Condition B resulted in less sleep. Shorter TST at the beginning of the study may indicate the adjustment period of the new sleep\/wake schedule. These results reveal that there are implications for sleep when sleep periods are reduced during watchkeeping.<\/jats:p>","DOI":"10.1093\/sleepadvances\/zpad035.067","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:37:53Z","timestamp":1698068273000},"page":"A26-A27","source":"Crossref","is-referenced-by-count":0,"title":["O067 Comparison of Sleep Quantity and Quality during Watchkeeping Schedules"],"prefix":"10.1093","volume":"4","author":[{"given":"I","family":"Marando","sequence":"first","affiliation":[{"name":"Universiry Of South Australia , Adelaide , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Owen","sequence":"additional","affiliation":[{"name":"Universiry Of South Australia , Adelaide , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Lushington","sequence":"additional","affiliation":[{"name":"Universiry Of South Australia , Adelaide , 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Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Blood Authority of Australia"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1177784"],"award-info":[{"award-number":["1177784"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1189490"],"award-info":[{"award-number":["1189490"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research 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Research Future Fund","doi-asserted-by":"crossref","award":["MRFFRD000049"],"award-info":[{"award-number":["MRFFRD000049"]}],"id":[{"id":"10.13039\/501100025520","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["HIM J"],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Background:<\/jats:title>\n Blood transfusion is a common medical intervention. For patients with acute critical bleeding, large volume \u201cmassive\u201d transfusion (MT) is required, and is potentially life-saving. However, the evidence-base for transfusion practice, particularly for critical bleeding\/MT management, is relatively weak, and has confounded the development of clinical best practice recommendations.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n The aim was to address this evidence gap by building the Australian and New Zealand Massive Transfusion Registry (ANZ-MTR). We describe how data collection, standardisation and interoperability of data sourced from multiple electronic information systems are managed, and share the lessons learned.<\/jats:p>\n <\/jats:sec>\n \n Innovation:<\/jats:title>\n The ANZ-MTR is a database of routine electronic hospital admission information, laboratory test results, transfusion records and outcomes of adults (18\u2009years and older) who have received a MT for any cause of acute critical bleeding, including trauma, major surgery, obstetric or gastrointestinal haemorrhage. Source data are provided by participating hospitals and are harmonised by the registry. Since its launch in 2011, the ANZ-MTR has captured over 9200 MT episodes from 29 hospitals.<\/jats:p>\n <\/jats:sec>\n \n What can be learned from this case:<\/jats:title>\n Effective communication with all custodians of the source data has been fundamental to the success of the registry. A preeminent outcome of this success is the current expansion of the registry to become the National Transfusion Dataset, which will capture comprehensive data for all transfusions.<\/jats:p>\n <\/jats:sec>\n \n Implications for health information management practice:<\/jats:title>\n The ANZ-MTR illustrates that complex and varied arrays of routinely collected clinical and hospital administrative data from multiple electronic information systems can be consolidated into a resource-rich clinical database.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/18333583251375121","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T09:44:49Z","timestamp":1758188689000},"page":"203-210","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Australian and New Zealand Massive Transfusion Registry: An innovation focusing on data collection, standardisation and interoperability between healthcare systems"],"prefix":"10.1177","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6689-2983","authenticated-orcid":false,"given":"Rosemary L","family":"Sparrow","sequence":"first","affiliation":[{"name":"Monash University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen E","family":"Haysom","sequence":"additional","affiliation":[{"name":"Monash University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9253-6635","authenticated-orcid":false,"given":"Joanna Bao-Ern","family":"Loh","sequence":"additional","affiliation":[{"name":"Monash University, Australia"},{"name":"Monash Health, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6270-9727","authenticated-orcid":false,"given":"Kirsten","family":"Caithness","sequence":"additional","affiliation":[{"name":"Monash University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2547-3670","authenticated-orcid":false,"given":"Karthik","family":"Mandapaka","sequence":"additional","affiliation":[{"name":"Monash University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6115-5394","authenticated-orcid":false,"given":"Cameron","family":"Wellard","sequence":"additional","affiliation":[{"name":"Monash University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9698-7185","authenticated-orcid":false,"given":"Zoe K","family":"McQuilten","sequence":"additional","affiliation":[{"name":"Monash University, Australia"},{"name":"Monash Health, Australia"},{"name":"Alfred Health, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7527-2340","authenticated-orcid":false,"given":"Erica M","family":"Wood","sequence":"additional","affiliation":[{"name":"Monash University, Australia"},{"name":"Monash Health, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"e_1_3_3_2_1","unstructured":"ACSQHC (2025) Australian Commission on Safety and Quality in Health Care. Australian register of clinical registries. Available at: https:\/\/www.safetyandquality.gov.au\/our-work\/indicators-measurement-and-reporting\/national-guidance-clinical-quality-registries\/australian-register-clinical-registries (accessed 6 May 2025)."},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.51443"},{"key":"e_1_3_3_4_1","unstructured":"Australian Institute of Health and Welfare (AIHW) (2015) Australian hospital peer groups. Available at: https:\/\/www.aihw.gov.au\/reports\/hospitals\/australian-hospital-peer-groups\/summary (accessed 6 May 2025)."},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-024-02713-x"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17507"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12428"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.17438"},{"key":"e_1_3_3_9_1","unstructured":"Cogstack (2025) Cogstack homepage. Available at: https:\/\/cogstack.org\/ (accessed 10 March 2025)."},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12361"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12434"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001410"},{"key":"e_1_3_3_13_1","unstructured":"Helix (2025) Monash University. Helix. Available at: https:\/\/www.monash.edu\/researchinfrastructure\/helix (accessed 10 March 2025)."},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-018-0623-9"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-024-08668-8"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04537-z"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2021.08.006"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12377"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEJ.0b013e328342310e"},{"key":"e_1_3_3_20_1","unstructured":"National Blood Authority (NBA) (2011) Patient blood management guidelines: Module 1 - critical bleeding massive transfusion. Available at: https:\/\/webarchive.nla.gov.au\/awa\/20140213214533\/http:\/\/blood.gov.au\/pbm-module-1 (accessed 10 March 2025)."},{"key":"e_1_3_3_21_1","unstructured":"National Blood Authority (NBA) (2023) Patient blood management guideline for adults with critical bleeding. Available at: https:\/\/www.blood.gov.au\/patient-blood-management-guideline-adults-critical-bleeding (accessed 10 March 2025)."},{"key":"e_1_3_3_22_1","unstructured":"National Blood Authority (NBA) (2024) National Blood Authority 2023-2024 annual report. Available at: https:\/\/www.blood.gov.au\/annual-report (accessed 10 March 2025)."},{"key":"e_1_3_3_23_1","unstructured":"National Health and Medical Research Council (NHMRC) (2023) Mind the gap \u2013 filling in the missing evidence for massive blood transfusion policy. Available at: https:\/\/www.nhmrc.gov.au\/about-us\/news-centre\/10-best-thirteenth-edition\/mind-gap-filling-missing-evidence-massive-blood-transfusion-policy (accessed 10 March 2025)."},{"key":"e_1_3_3_24_1","unstructured":"National Transfusion Dataset (NTD) (2025) Pilot interactive blood usage dashboard. Available at: https:\/\/www.transfusiondataset.com\/ (accessed 10 March 2025)."},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-016-2261-6"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X20974035"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2013.02.003"},{"key":"e_1_3_3_28_1","unstructured":"School of Public Health and Preventive Medicine (SPHPM) (2023) Monash Univerity. Monash clinical registries porfolio report 2023. 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Available at: https:\/\/www.monash.edu\/medicine\/sphpm\/registries (accessed 10 March 2025)."},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15149"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-020-01857-4"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0301557"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12121"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16027"}],"container-title":["Health Information Management Journal"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/18333583251375121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/18333583251375121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/18333583251375121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:04:49Z","timestamp":1777449889000},"score":7.5670524,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/18333583251375121"}},"issued":{"date-parts":[[2025,9,18]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/18333583251375121"],"URL":"https:\/\/doi.org\/10.1177\/18333583251375121","ISSN":["1833-3583","1833-3575"],"issn-type":[{"value":"1833-3583","type":"print"},{"value":"1833-3575","type":"electronic"}],"published":{"date-parts":[[2025,9,18]]}},{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:13:31Z","timestamp":1778717611138,"version":"3.51.4"},"reference-count":2,"publisher":"CSIRO Publishing","issue":"S1","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2026,5,14]]},"abstract":"This extended abstract presents a practitioner-focused, maintenance-led approach for post-acquisition operations transformation in mature offshore upstream assets. Rather than starting with optimisation, the approach establishes minimum governance controls such as Computerised Maintenance Management System structure, planning cadence, performance reporting and change control to create a defensible baseline for risk-based decisions. A second phase then applies targeted criticality, maintenance strategy and spares policy optimisation supported by analytics, artificial intelligence and multidisciplinary engineering validation. The approach was delivered by an Australian-based team supporting a Southeast Asian offshore portfolio following acquisition. The implementation reduced planned maintenance effort by approximately 25%, reduced outsourced specialist maintenance by approximately 12%, and reduced inventory holdings for in-scope materials by approximately 12% (safety-critical) and 30% (production-critical), with payback achieved within 5 to 6 months. The key contribution is a repeatable sequence, method and practical implementation considerations that can be applied to similar late-life and post-acquisition assets.<\/jats:p>","DOI":"10.1071\/ep25128","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:56:27Z","timestamp":1778716587000},"source":"Crossref","is-referenced-by-count":0,"title":["Beyond acquisition: a practical sequence for maintenance-led transformation in mature offshore operations"],"prefix":"10.1071","volume":"66","author":[{"given":"Anton","family":"Cuschieri","sequence":"first","affiliation":[{"name":"AWood Australia, Melbourne, Vic, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Loke","sequence":"additional","affiliation":[{"name":"AWood Australia, Melbourne, Vic, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Carydias","sequence":"additional","affiliation":[{"name":"AWood Australia, Melbourne, Vic, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Lapsley","sequence":"additional","affiliation":[{"name":"AWood Australia, Melbourne, Vic, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"2026051319562250100_R1"},{"key":"2026051319562250100_R2"}],"container-title":["Australian Energy Producers Journal"],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/doi\/10.1071\/EP25128\/1867686\/ep25128.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/doi\/10.1071\/EP25128\/1867686\/ep25128.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:56:27Z","timestamp":1778716587000},"score":7.5670156,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/ep\/article\/66\/S1\/EP25128\/271698\/Beyond-acquisition-a-practical-sequence-for"}},"issued":{"date-parts":[[2026,5,14]]},"references-count":2,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2026,5,14]]}},"URL":"https:\/\/doi.org\/10.1071\/ep25128","ISSN":["2982-0308"],"issn-type":[{"value":"2982-0308","type":"electronic"}],"published":{"date-parts":[[2026,5,14]]},"article-number":"EP25128"},{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:08:29Z","timestamp":1772752109199,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,8]],"date-time":"2017-10-08T00:00:00Z","timestamp":1507420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000950","name":"Cancer Council South Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001787","name":"University of South Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009843","name":"South Australian Health and Medical Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evaluation Clinical Practice"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Clinical registry data from major South Australian public hospitals were used to investigate trends in invasive breast\u2010cancer treatment and survival by age.<\/jats:p><\/jats:sec>Methods<\/jats:title>Disease\u2010specific survival was calculated for the 1980 to 2013 diagnostic period using Kaplan\u2010Meier product\u2010limit estimates, with a censoring of live cases on December 31, 2014. Cox proportional hazards regression was used to examine differences in survival by age and tumour characteristic. First\u2010round treatments following diagnosis were analysed, using multiple logistic regression to adjust for confounding.<\/jats:p><\/jats:sec>Results<\/jats:title>Five\u2010year survival increased from 75% in the 1980s to 87% in 2000 to 2013, consistent with national trends, and with increases occurring irrespective of age. There was an increased use of breast conserving surgery, radiotherapy, chemotherapy, and hormone treatments. Five\u2010year survival was lower for women aged 80+ years, increasing from 65% in the 1980s to 74% in 2000 to 2013. Lower survival in these older women persisted after adjusting for TNM stage, other clinical variables, and diagnostic year, without evidence of a reduced disparity over time. Older women were less likely to have surgery, radiotherapy, and chemotherapy throughout 1980 to 2013. By comparison, their use of hormone therapy was elevated. The adjusted relative odds of mastectomy (as opposed to breast conserving surgery) were lower for the 80+ year age range.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>\n\nBreast\u2010cancer survival increases applied to all ages, including 80+ years, but poorer outcomes persisted in this older group and the gap did not reduce.<\/jats:p><\/jats:list-item>\nA key question is whether the best trade\u2010off now exists between optimally therapeutic cancer treatment and accommodations for frailty and co\u2010morbidity in the aged, or whether opportunities exist for better trade\u2010offs and better survival.<\/jats:p><\/jats:list-item>\nLocal registry data are important for describing local service activity and outcomes by age for local service providers, health administrations and consumer groups; monitoring disparities; and indicating effects of local initiatives.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/jep.12819","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T04:42:37Z","timestamp":1507524157000},"page":"1433-1443","source":"Crossref","is-referenced-by-count":6,"title":["Female breast cancer management and survival: The experience of major public hospitals in South Australia over 3 decades\u2014trends by age and in the elderly"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6442-4409","authenticated-orcid":false,"given":"David","family":"Roder","sequence":"first","affiliation":[{"name":"Centre for Population Health Research University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gelareh","family":"Farshid","sequence":"additional","affiliation":[{"name":"BreastScreen SA SA Health Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Kollias","sequence":"additional","affiliation":[{"name":"Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogda","family":"Koczwara","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Flinders University Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Karapetis","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Flinders University Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqui","family":"Adams","sequence":"additional","affiliation":[{"name":"Lyell McEwin Hospital Elizabeth Vale South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Joshi","sequence":"additional","affiliation":[{"name":"Medical Oncology, Lyell McEwin Hospital Elizabeth Vale South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy","family":"Keefe","sequence":"additional","affiliation":[{"name":"Adelaide South Australia Australia"},{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Miller","sequence":"additional","affiliation":[{"name":"School of Public Health University of Adelaide Adelaide South Australia Australia"},{"name":"South Australian Health and Medical Research Institute Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Powell","sequence":"additional","affiliation":[{"name":"Population Health Research Group South Australian Health and Medical Research Institute (SAHMRI) Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kellie","family":"Fusco","sequence":"additional","affiliation":[{"name":"Centre for Population Health Research University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Eckert","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8980-1194","authenticated-orcid":false,"given":"Elizabeth","family":"Buckley","sequence":"additional","affiliation":[{"name":"Centre for Population Health Research University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerri","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Centre for Population Health Research University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Price","sequence":"additional","affiliation":[{"name":"Haematology and Medical Oncology The Queen Elizabeth Hospital Woodville South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,8]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"FerlayJ SoerjomataramI ErvikM et al.GLOBOCAN 2012 v1.0.Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11[Internet]. Lyon France: International Agency for Research on Cancer 2013. Available fromhttp:\/\/globocan.iarc.fr. Accessed 3 March 2017."},{"key":"e_1_2_7_3_1","unstructured":"Australian Institute of Health and Welfare (AIHW).Australian Cancer Incidence and Mortality (ACIM) books. AIHW: Canberra 2013.http:\/\/www.aihw.gov.au\/acim\u2010books\/. Accessed 3 March 2017."},{"key":"e_1_2_7_4_1","unstructured":"Australian Institute of Health and Welfare (AIHW).Cancer survival and prevalence in Australia: period estimates from 1982 to 2010. Cancer Series no. 69. Cat. No. CAN 65. 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Accessed 3 March 2017."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810515)47:10<2358::AID-CNCR2820471006>3.0.CO;2-K"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890301)63:5<976::AID-CNCR2820630532>3.0.CO;2-A"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.046"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.4208"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70378-9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.07.015"},{"key":"e_1_2_7_16_1","unstructured":"Australian Bureau of Statistics.3222.0\u2010Population projections Australia 2012 (base) to 2101. 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Adelaide: South Australian Department of Health 2007."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02243.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv298"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61629-2"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60488-8"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2016.04.001"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2011.05998.x"}],"container-title":["Journal of Evaluation in Clinical Practice"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjep.12819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jep.12819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jep.12819","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jep.12819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T07:35:29Z","timestamp":1692948929000},"score":7.566939,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jep.12819"}},"issued":{"date-parts":[[2017,10,8]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/jep.12819"],"URL":"https:\/\/doi.org\/10.1111\/jep.12819","archive":["Portico"],"ISSN":["1356-1294","1365-2753"],"issn-type":[{"value":"1356-1294","type":"print"},{"value":"1365-2753","type":"electronic"}],"published":{"date-parts":[[2017,10,8]]}},{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:41:40Z","timestamp":1761720100446,"version":"build-2065373602"},"reference-count":1,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2012,4]]},"abstract":"Lactating breasts can increase their capacity to produce milk to meet the demand of the infants. The breast milk storage capacity (SC) is related to milk production (MP) in term mothers in established lactation. This study investigates the SC and MP in early lactation of preterm and term mothers.<\/jats:p>\n \n Nineteen breast expressing preterm and sixteen breastfeeding mothers collected milk samples and measured their milk production by either weighing the bottle with an electronic kitchen scale or the baby with BabyWeigh scales (Medela AG) at home before and after each breastfeed or breast expression over a 24\u2010h period between days 10 and 43 postpartum. The 24\u2010h MP and SC were calculated (Kent\n et al.<\/jats:italic>\n , 2003).\n <\/jats:p>\n \n \n \n \n \n \n \n \n \n \n \n 24\u2010h Milk production (ml) (mean\u00b1SD)<\/jats:th>\n Breast milk storage capacity (ml) (mean\u00b1SD)<\/jats:th>\n <\/jats:tr>\n \n \n Left<\/jats:th>\n Right<\/jats:th>\n Left<\/jats:th>\n Right<\/jats:th>\n <\/jats:tr>\n <\/jats:thead>\n \n \n Preterm<\/jats:td>\n 398 \u00b1 182<\/jats:td>\n 388 \u00b1 198<\/jats:td>\n 142 \u00b1 56<\/jats:td>\n 133 \u00b1 68<\/jats:td>\n <\/jats:tr>\n \n Term<\/jats:td>\n 382 \u00b1 142<\/jats:td>\n 431 \u00b1 122<\/jats:td>\n 170 \u00b1 66<\/jats:td>\n 174 \u00b1 44<\/jats:td>\n <\/jats:tr>\n <\/jats:tbody>\n <\/jats:table>\n <\/jats:table-wrap>\n <\/jats:p>\n Mean MP and SC were not significantly different between breasts or between preterm and term mothers.<\/jats:p>\n The SC of both preterm and term mothers was positively related (p=0.0001) to the MP of their breasts.<\/jats:p>\n Despite premature delivery, SC and MP of preterm mothers\u2019 breasts can reach to similar level as the term mothers\u2019 breasts.<\/jats:p>\n \n \n Research Support: Medela AG, Switzerland<\/jats:italic>\n <\/jats:bold>\n .\n <\/jats:p>","DOI":"10.1096\/fasebj.26.1_supplement.806.4","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T11:18:52Z","timestamp":1624274332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Storage capacity of the human breast"],"prefix":"10.1096","volume":"26","author":[{"given":"Jacqueline Coral","family":"Kent","sequence":"first","affiliation":[{"name":"University of Western Australia Crawley Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracey","family":"Williams","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Sakalidis","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter E","family":"Hartmann","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching Tat","family":"Lai","sequence":"additional","affiliation":[{"name":"University of Western Australia Crawley Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1177\/0890334403252473"}],"container-title":["The FASEB Journal"],"language":"en","deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:20:58Z","timestamp":1761697258000},"score":7.5666738,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fasebj.26.1_supplement.806.4"}},"issued":{"date-parts":[[2012,4]]},"references-count":1,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1096\/fasebj.26.1_supplement.806.4"],"URL":"https:\/\/doi.org\/10.1096\/fasebj.26.1_supplement.806.4","archive":["Portico"],"ISSN":["0892-6638","1530-6860"],"issn-type":[{"type":"print","value":"0892-6638"},{"type":"electronic","value":"1530-6860"}],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"2012-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:18:02Z","timestamp":1760955482467,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"4S_Part_8","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.jalz.2014.05.274","type":"journal-article","created":{"date-parts":[[2014,9,6]],"date-time":"2014-09-06T10:48:36Z","timestamp":1410000516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["P1\u2010039: MAPT METHYLATION IN ALZHEIMER'S DISEASE"],"prefix":"10.1002","volume":"10","author":[{"given":"Kirsten","family":"Coupland","sequence":"first","affiliation":[{"name":"Neuroscience Research Australia Randwick\u2010Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woojin S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Randwick\u2010Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenda","family":"Halliday","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Randwick\u2010Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Dobson\u2010Stone","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Randwick\u2010Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.J.","family":"Kwok","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Randwick\u2010Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526014009212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526014009212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.jalz.2014.05.274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2014.05.274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.jalz.2014.05.274","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2014.05.274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:39:57Z","timestamp":1759855197000},"score":7.5666738,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1016\/j.jalz.2014.05.274"}},"issued":{"date-parts":[[2014,7]]},"references-count":0,"journal-issue":{"issue":"4S_Part_8","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1016\/j.jalz.2014.05.274"],"URL":"https:\/\/doi.org\/10.1016\/j.jalz.2014.05.274","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"type":"print","value":"1552-5260"},{"type":"electronic","value":"1552-5279"}],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"2011-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:39:17Z","timestamp":1788910757324,"version":"build-2803163510"},"reference-count":39,"publisher":"American Diabetes Association","issue":"11","license":[{"start":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T00:00:00Z","timestamp":1508716800000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"name":"Commercialization Australia","award":["CAU05922"],"award-info":[{"award-number":["CAU05922"]}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council of Australia","doi-asserted-by":"publisher","award":["513781"],"award-info":[{"award-number":["513781"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council of Australia","doi-asserted-by":"publisher","award":["1042231"],"award-info":[{"award-number":["1042231"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council of Australia","doi-asserted-by":"publisher","award":["1058260"],"award-info":[{"award-number":["1058260"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2017,11,1]]},"abstract":"\n OBJECTIVE<\/jats:title>\n To assess the ability of plasma apolipoprotein (apo) A-IV (apoA4), apo C-III, CD5 antigen-like (CD5L), complement C1q subcomponent subunit B (C1QB), complement factor H\u2013related protein 2, and insulin-like growth factor binding protein 3 (IBP3) to predict rapid decline in estimated glomerular filtration rate (eGFR) in type 2 diabetes.<\/jats:p>\n <\/jats:sec>\n \n RESEARCH DESIGN AND METHODS<\/jats:title>\n Mass spectrometry was used to measure baseline biomarkers in 345 community-based patients (mean age 67.0 years, 51.9% males) from the Fremantle Diabetes Study Phase II (FDS2). Multiple logistic regression was used to determine clinical predictors of rapid eGFR decline trajectory defined by semiparametric group-based modeling over a 4-year follow-up period. The incremental benefit of each biomarker was then assessed. Similar analyses were performed for a \u226530% eGFR fall, incident chronic kidney disease (eGFR &lt;60 mL\/min\/1.73 m2), and eGFR decline of \u22655 mL\/min\/1.73 m2\/year.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Based on eGFR trajectory analysis, 35 participants (10.1%) were defined as \u201crapid decliners\u201d (mean decrease 2.9 mL\/min\/1.73 m2\/year). After adjustment for clinical predictors, apoA4, CD5L, and C1QB independently predicted rapid decline (odds ratio 2.40 [95% CI 1.24\u20134.61], 0.52 [0.29\u20130.93], and 2.41 [1.14\u20135.11], respectively) and improved model performance and fit (P &lt; 0.001), discrimination (area under the curve 0.75\u20130.82, P = 0.039), and reclassification (net reclassification index 0.76 [0.63\u20130.89]; integrated discrimination improvement 6.3% [2.1\u201310.4%]). These biomarkers and IBP3 contributed to improved model performance in predicting other indices of rapid eGFR decline.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n The current study has identified novel plasma biomarkers (apoA4, CD5L, C1QB, and IBP3) that may improve the prediction of rapid decline in renal function independently of recognized clinical risk factors in type 2 diabetes.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/dc17-0911","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:25:34Z","timestamp":1504052734000},"page":"1548-1555","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":76,"title":["Identification of Novel Circulating Biomarkers Predicting Rapid Decline in Renal Function in Type 2 Diabetes: The Fremantle Diabetes Study Phase II"],"prefix":"10.2337","volume":"40","author":[{"given":"Kirsten E.","family":"Peters","sequence":"first","affiliation":[{"name":"Medical School, Faculty of Health and Medical Sciences, The University of Western Australia, Fremantle, Western Australia, Australia"},{"name":"Proteomics International, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Medical School, Faculty of Health and Medical Sciences, The University of Western Australia, Fremantle, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ito","sequence":"additional","affiliation":[{"name":"Proteomics International, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaye","family":"Winfield","sequence":"additional","affiliation":[{"name":"Proteomics International, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Stoll","sequence":"additional","affiliation":[{"name":"Proteomics International, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Bringans","sequence":"additional","affiliation":[{"name":"Proteomics International, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Lipscombe","sequence":"additional","affiliation":[{"name":"Proteomics International, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-7411","authenticated-orcid":false,"given":"Timothy M.E.","family":"Davis","sequence":"additional","affiliation":[{"name":"Medical School, Faculty of Health and Medical Sciences, The University of Western Australia, Fremantle, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"2022031301530208200_B1","unstructured":"United States Renal Data System. 2015 annual data report [article online], 2015. Available from https:\/\/www.usrds.org\/2015\/view\/. Accessed March 2017"},{"key":"2022031301530208200_B2","unstructured":"Centers for Disease Control and Prevention. National Chronic Kidney Disease Fact Sheet, 2017. Available from https:\/\/www.cdc.gov\/diabetes\/pubs\/pdf\/kidney_factsheet.pdf. 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Care"],"language":"en","link":[{"URL":"http:\/\/care.diabetesjournals.org\/syndication\/doi\/10.2337\/dc17-0911","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/40\/11\/1548\/551979\/dc170911.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/40\/11\/1548\/551979\/dc170911.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T05:56:56Z","timestamp":1647151016000},"score":7.5666,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/40\/11\/1548\/36999\/Identification-of-Novel-Circulating-Biomarkers"}},"issued":{"date-parts":[[2017,8,29]]},"references-count":39,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,8,29]]},"published-print":{"date-parts":[[2017,11,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc17-0911","ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"published":{"date-parts":[[2017,8,29]]}},{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:24:59Z","timestamp":1767997499119,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T00:00:00Z","timestamp":1449619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>To identify the causes of sports\u2010related eye and adnexal injuries in children in Perth, Western Australia, to determine which sporting activities pose the highest risk of eye and adnexal injury to children.<\/jats:p><\/jats:sec>Methods<\/jats:title>We performed a 12\u2010year retrospective review of children admitted to hospital from 2002 to 2013 with sports\u2010related ocular and adnexal eye injuries. The main outcome measures were the cause and type of ocular and adnexal injuries, age and gender risk factors.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 93 cases of sports\u2010related ocular and adnexal injury were identified in the 12\u2010year time period. A peak in injuries occurred for 12\u2010 to 14\u2010year\u2010olds with a second peak in 6\u2010 to 8\u2010year\u2010olds; the median age was 8.82\u00a0years (range\u00a0=\u00a01.59\u201316.47). Cycling, football (including soccer and Australian Rules Football), tennis, trampolining, fishing and swimming were the sports responsible for the greatest number of injuries, a total of 63%. More than one\u2010third (35%) of injuries resulted from being struck by a blunt object, and more than a quarter (26%) were as a result of contact with a blunt projectile.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Serious ocular and adnexal injuries have occurred in children as a result of participating in sports, with cycling and football being the largest contributors in the 12\u2010year period we assessed. As we continue to encourage children to spend more time participating in sports and recreational activities, identifying associated risk factors will help us develop injury prevention strategies to promote eye safety for children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.12911","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T17:59:26Z","timestamp":1449683966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Sports\u2010related eye and adnexal injuries in the W<\/scp>estern A<\/scp>ustralian paediatric population"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7732-0323","authenticated-orcid":false,"given":"Annette K.","family":"Hoskin","sequence":"first","affiliation":[{"name":"Lions Eye Institute Perth Western Australia Australia"},{"name":"Centre for Ophthalmology and Visual Science University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Marie E.","family":"Yardley","sequence":"additional","affiliation":[{"name":"Lions Eye Institute Perth Western Australia Australia"},{"name":"Princess Margaret Hospital for Children Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Hanman","sequence":"additional","affiliation":[{"name":"Lions Eye Institute Perth Western Australia Australia"},{"name":"Princess Margaret Hospital for Children Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Lam","sequence":"additional","affiliation":[{"name":"Centre for Ophthalmology and Visual Science University of Western Australia Perth Western Australia Australia"},{"name":"Princess Margaret Hospital for Children Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Mackey","sequence":"additional","affiliation":[{"name":"Lions Eye Institute Perth Western Australia Australia"},{"name":"Centre for Ophthalmology and Visual Science University of Western Australia Perth Western Australia Australia"},{"name":"Princess Margaret Hospital for Children Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.34.6.456"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1999.tb127920.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2001.111707"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2012-092014"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12000"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.50.4.436"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1440-2440(05)80029-5"},{"key":"e_1_2_6_9_1","unstructured":"EvansB(2014):Standards Australia (PP1178). 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(Accessed on 10 Jun 2014)."},{"key":"e_1_2_6_25_1","first-page":"1","article-title":"The eye and sports medicine","volume":"5","author":"Vinger PF","year":"1994","journal-title":"Clin Ophthalmol"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.026229"}],"container-title":["Acta Ophthalmologica"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.12911","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.12911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:45:59Z","timestamp":1695487559000},"score":7.5665913,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.12911"}},"issued":{"date-parts":[[2015,12,9]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/aos.12911"],"URL":"https:\/\/doi.org\/10.1111\/aos.12911","archive":["Portico"],"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"published":{"date-parts":[[2015,12,9]]},"assertion":[{"value":"2015-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T10:32:36Z","timestamp":1787481156501,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001797","name":"Curtin University of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001798","name":"Edith Cowan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001798","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001799","name":"Murdoch University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001799","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001063","name":"Raine Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023759","name":"Telethon Kids Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023759","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001800","name":"University of Notre Dame Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001800","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001801","name":"University of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001069","name":"Women and Infants Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2024,1]]},"abstract":"Aim<\/jats:title>To investigate the long\u2010term effects of early\u2010life recurrent otitis media (OM) and subsequent behavioural problems in children at the age of 10\u2009years.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data from the Raine Study, a longitudinal pregnancy cohort, were used to categorise children into those with three or more episodes of OM (rOM group) and those without a history of recurrent OM in the first 3\u2009years of life (reference group). The parent report Strengths and Difficulties Questionnaire was used to assess child behaviour at the age of 10\u2009years. Parental questionnaires were used to report past and present diagnoses of various mental health and developmental conditions, including attention, anxiety, depression, learning, and speech\u2010language problems. Multiple linear and logistic models were used to analyse the data and were adjusted for a fixed set of key confounding variables.<\/jats:p><\/jats:sec>Results<\/jats:title>The linear regression analysis revealed significant, independent associations between a history of recurrent OM and higher Strengths and Difficulties Questionnaire scores, including total, internalising, externalising, emotional, attention\/hyperactivity and peer problems subscales. Logistic regression analyses revealed an independent increased likelihood for children in the rOM group to have a diagnosis of attention, anxiety, learning and speech\u2010language problems.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Children at 10\u2009years of age with an early history of recurrent OM are more likely to exhibit attentional and behavioural problems when compared to children without a history of recurrent OM. These findings highlight the association between early\u2010life recurrent OM and later behavioural problems that may require professional allied health\u2010care interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16518","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T09:45:50Z","timestamp":1699955150000},"page":"12-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Recurrent otitis media and behaviour problems in middle childhood: A longitudinal cohort study"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4807-4004","authenticated-orcid":false,"given":"Ali AH","family":"Altamimi","sequence":"first","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Western Australia Australia"},{"name":"School of Medicine The University of Western Australia Perth Western Australia Australia"},{"name":"Faculty of Life Sciences Kuwait University Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Robinson","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman MA","family":"Alenezi","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Western Australia Australia"},{"name":"School of Medicine The University of Western Australia Perth Western Australia Australia"},{"name":"Faculty of Allied Health Sciences Kuwait University Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Veselinovi\u0107","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Western Australia Australia"},{"name":"School of Human Sciences The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn SM","family":"Choi","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Western Australia Australia"},{"name":"School of Human Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"School of Allied Health Faculty of Health Sciences, Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G","family":"Brennan\u2010Jones","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Western Australia Australia"},{"name":"School of Medicine The University of Western Australia Perth Western Australia Australia"},{"name":"Audiology Department Perth Children's Hospital Perth Western Australia Australia"},{"name":"School of Allied Health Faculty of Health Sciences, Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.63"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2016.1250960"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.85.2.91"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.80.1.28"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13094"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1346-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2020.109961"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2023.111545"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818797598"},{"key":"e_1_2_7_11_1","first-page":"1384","article-title":"Cohort profile: The Western Australian pregnancy cohort (Raine) study\u2013generation 2","volume":"46","author":"Straker L","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200111000-00015"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12741"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2019.109837"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0017896919890898"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2007.08.006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000479"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.85.3.442"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992288702600508"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1978.47.3.723"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8930904"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489416671333"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2015.1129552"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2009.tb02931.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218518"}],"container-title":["Journal of Paediatrics and Child Health"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T05:08:46Z","timestamp":1706159326000},"score":7.5665646,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.16518"}},"issued":{"date-parts":[[2023,11,14]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/jpc.16518"],"URL":"https:\/\/doi.org\/10.1111\/jpc.16518","archive":["Portico"],"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"published":{"date-parts":[[2023,11,14]]},"assertion":[{"value":"2023-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T02:26:52Z","timestamp":1779416812903,"version":"3.53.1"},"reference-count":0,"publisher":"Clinical Exercise Physiology Association","issue":"s2","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2026,4]]},"abstract":"\n BACKGROUND:<\/jats:title>\n Adolescent Idiopathic Scoliosis (AIS) is a three-dimensional spinal condition that may be associated with altered trunk muscle function and reduced muscular endurance. Impaired endurance of the trunk extensors and abdominal musculature has been reported in adolescents with AIS and may contribute to postural instability and long-term musculoskeletal dysfunction. Physiotherapeutic scoliosis-specific exercises (PSSE) aim to address these impairments through active self-correction, postural control, and stabilization strategies. ScoliBalance\u00ae is a structured PSSE program designed to improve neuromuscular control, postural alignment, and functional strength. While previous research has explored trunk muscle endurance outcomes using combined treatment approaches, evidence examining the isolated effect of ScoliBalance on trunk muscle endurance remains limited.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVE:<\/jats:title>\n To investigate changes in trunk muscle endurance in adolescents with idiopathic scoliosis following participation in a ScoliBalance\u00ae exercise program as the sole intervention.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n A retrospective case study was conducted involving 9 adolescents with idiopathic scoliosis (1 M, 8 F). The mean age at commencement of treatment was 14.7 \u00b1 1.9 years. Participants completed an individualized ScoliBalance\u00ae program based on PSSE principles, emphasizing three-dimensional active self-correction, postural stabilization, and integration of corrected posture into functional activities. Exercises were delivered during one-on-one clinical sessions and reinforced through a prescribed daily home exercise program. Trunk extensor endurance (TE) and abdominal endurance (AE) were assessed using standardized clinical endurance tests at baseline and following 36.4 \u00b1 25.2 months of intervention. Endurance was recorded as time (seconds) maintained in each test position, with a maximum test duration of 240 seconds.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n All 9 participants demonstrated improvements in trunk muscle endurance following completion of the ScoliBalance-only program. Mean TE endurance increased 94.4%, from 72.9 \u00b1 39.1 seconds at baseline to 141.7 \u00b1 50.4 seconds at follow-up, representing a mean improvement of 68.8 seconds (paired t(8)=3.82, p=0.005, Cohen\u2019s d=1.27). AE increased 30.1%, from 136.0 \u00b1 78.5 seconds at baseline to 176.9 \u00b1 79.4 seconds at follow-up, with a mean improvement of 40.9 seconds (paired t(8)=2.37, p=0.045, Cohen's d=0.79). No participant demonstrated a reduction in trunk muscle endurance over the intervention period.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n Participation in a ScoliBalance\u00ae exercise program as a standalone intervention was associated with statistically significant and clinically meaningful improvements (large effect for TE and AE) in trunk extensor and abdominal muscle endurance in this cohort of adolescents with idiopathic scoliosis. These findings support the role of ScoliBalance as an effective PSSE-based approach for enhancing trunk muscle endurance. Further prospective studies with larger sample sizes are warranted to confirm these findings and to explore the relationship between trunk muscle endurance, postural control, and long-term scoliosis outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.31189\/2165-7629-15-s2.258","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:59:20Z","timestamp":1777341560000},"page":"258","source":"Crossref","is-referenced-by-count":0,"title":["IMPROVEMENTS IN TRUNK EXTENSOR AND ABDOMINAL MUSCLE ENDURANCE IN ADOLESCENTS WITH IDIOPATHIC SCOLIOSIS FOLLOWING A STANDALONE SCOLIBALANCE\u00ae PHYSIOTHERAPEUTIC SCOLIOSIS-SPECIFIC EXERCISE PROGRAM: A RETROSPECTIVE CASE SERIES"],"prefix":"10.31189","volume":"15","author":[{"given":"Rosemary","family":"Mirenzi","sequence":"first","affiliation":[{"name":"ScoliCare Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora-Lee","family":"Doueihi","sequence":"additional","affiliation":[{"name":"ScoliCare Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Oakley","sequence":"additional","affiliation":[{"name":"Innovative Spine and Wellness, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeb","family":"McAviney","sequence":"additional","affiliation":[{"name":"ScoliCare Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16145","container-title":["Journal of Clinical Exercise Physiology"],"link":[{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/15\/s2\/article-p258-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/15\/s2\/article-p258-s.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jcep.kglmeridian.com\/downloadpdf\/journals\/ceph\/15\/s2\/article-p258-s.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T01:51:55Z","timestamp":1779414715000},"score":7.5664144,"resource":{"primary":{"URL":"https:\/\/jcep.kglmeridian.com\/view\/journals\/ceph\/15\/s2\/article-p258-s.xml"}},"issued":{"date-parts":[[2026,4]]},"references-count":0,"journal-issue":{"issue":"s2"},"URL":"https:\/\/doi.org\/10.31189\/2165-7629-15-s2.258","ISSN":["2165-7629","2165-6193"],"issn-type":[{"value":"2165-7629","type":"electronic"},{"value":"2165-6193","type":"print"}],"published":{"date-parts":[[2026,4]]}},{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T07:13:14Z","timestamp":1648969994836},"reference-count":0,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"16_suppl","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1200\/jco.2005.23.16_suppl.6126","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T13:55:09Z","timestamp":1487858109000},"page":"6126-6126","source":"Crossref","is-referenced-by-count":0,"title":["Squamous cell carcinoma of the anal canal at the Queen Elizabeth Hospital: A local experience"],"prefix":"10.1200","volume":"23","author":[{"given":"T. J.","family":"Price","sequence":"first","affiliation":[{"name":"QEH, Adelaide, Australia; Royal Adelaide Hosp, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zakaria","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Royal Adelaide Hosp, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Rodda","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Royal Adelaide Hosp, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hewett","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Royal Adelaide Hosp, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Rieger","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Royal Adelaide Hosp, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Stephens","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Royal Adelaide Hosp, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Pittman","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Royal Adelaide Hosp, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Patterson","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Royal Adelaide Hosp, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Borg","sequence":"additional","affiliation":[{"name":"QEH, Adelaide, Australia; Royal Adelaide Hosp, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","container-title":["Journal of Clinical Oncology"],"language":"en","link":[{"URL":"http:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/jco.2005.23.16_suppl.6126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T17:06:45Z","timestamp":1574874405000},"score":7.566122,"resource":{"primary":{"URL":"http:\/\/ascopubs.org\/doi\/10.1200\/jco.2005.23.16_suppl.6126"}},"issued":{"date-parts":[[2005,6]]},"references-count":0,"journal-issue":{"issue":"16_suppl","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1200\/jco.2005.23.16_suppl.6126"],"URL":"https:\/\/doi.org\/10.1200\/jco.2005.23.16_suppl.6126","ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"published":{"date-parts":[[2005,6]]}},{"indexed":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T22:31:13Z","timestamp":1722637873695},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2021,12,17]]},"abstract":"Abstract<\/jats:title>\n Meaningful activity engagement in later life is widely recognized as crucial for ageing well, but age-related changes and transitions can impede such participation. A behavioral activation framework can provide a person-centred, value-consistent therapeutic approach to increasing activity engagement that is both easy to administer, cost effective and accessible to a broad audience. Although there is evidence supporting the utility of behavioral activation as a treatment for depression in older adults, this study will be the first to examine whether a behavioral activation is more effective in increasing activity engagement and psychological wellbeing among a non-clinical sample of older adults, compared to a multi component positive psychology intervention. This randomized controlled trial will examine the impact of two therapeutic approaches on activity engagement and wellbeing among older adults. One hundred and fifty adults aged 65+ who have relatively lower scores on a measure of engagement with life will be randomized to either a behavioral activation-based intervention, or a multi-component positive psychology intervention. The interventions will involve six individual weekly sessions conducted via telephone or video conference. Participants will be assessed pre-, post-intervention, and at three months follow-up. Outcome measures will include activity engagement, positive affect, and psychological wellbeing. Intra-individual variability will also be assessed via micro-longitudinal data in the behavioral activation condition. This study will be the first to provide evidence to the effectiveness of behavioral activation as an intervention to increase activity engagement and wellbeing among older adults, compared to other therapeutic approaches to increase psychological wellbeing.<\/jats:p>","DOI":"10.1093\/geroni\/igab046.3279","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T17:17:28Z","timestamp":1639761448000},"page":"903-904","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of Behavioral Activation on Older Adults' Engagement and Wellbeing: A Randomized Control Trial Protocol"],"prefix":"10.1093","volume":"5","author":[{"given":"Julia Turner","family":"Scott","sequence":"first","affiliation":[{"name":"Flinders University, Brompton, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Luszcz","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Mazzucchelli","sequence":"additional","affiliation":[{"name":"Curtin University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Walker","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Windsor","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,12,17]]},"container-title":["Innovation in Aging"],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/innovateage\/article-pdf\/5\/Supplement_1\/903\/43188908\/igab046.3279.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/innovateage\/article-pdf\/5\/Supplement_1\/903\/43188908\/igab046.3279.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T16:05:06Z","timestamp":1648742706000},"score":7.5660343,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/innovateage\/article\/5\/Supplement_1\/903\/6468117"}},"issued":{"date-parts":[[2021,12,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2021,12,17]]}},"URL":"https:\/\/doi.org\/10.1093\/geroni\/igab046.3279","ISSN":["2399-5300"],"issn-type":[{"value":"2399-5300","type":"electronic"}],"published-other":{"date-parts":[[2021,12,1]]},"published":{"date-parts":[[2021,12,1]]}},{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:46:21Z","timestamp":1756385181713,"version":"3.40.5"},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T00:00:00Z","timestamp":1624147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Med Imag Rad Onc"],"published-print":{"date-parts":[[2022,4]]},"abstract":"Summary<\/jats:title>A 36\u2010year\u2010old female patient was diagnosed with a parosteal lipoma arising from the left 3rd rib. This was preluded by a 5\u2010year history of an asymptomatic and stable mass at the medial aspect of the left scapula. It had displayed an interval enlargement in the preceding 3\u2009months which prompted investigation to rule out an aggressive lesion. The patient was investigated with CT, MRI and PET scan which demonstrated a well\u2010circumscribed juxtacortical fatty mass with osseous excrescence and no enhancing soft tissue components or FDG avidity in the fatty component, in keeping with a parosteal lipoma. CT\u2010guided biopsy allowed histopathological correlation which facilitated the exclusion of an aggressive lesion and supported the imaging diagnosis. This case is a pertinent educational tool for radiologists and orthopaedic surgeons as it characterises a rare and benign pathology in an uncommon location, with mimicry of malignant differential diagnoses such as liposarcoma and chondrosarcoma. We aim to bring awareness to this condition and its typical imaging characteristics and thus allowing radiologists to make more confident conclusions in future cases.<\/jats:p>","DOI":"10.1111\/1754-9485.13264","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T05:55:57Z","timestamp":1624254957000},"page":"411-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Parosteal lipoma of the rib: A rare condition in an uncommon location"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4455-609X","authenticated-orcid":false,"given":"Roland Z","family":"White","sequence":"first","affiliation":[{"name":"Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"School of Medicine University of Adelaide Adelaide South Australia 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We quantified thermal tolerance in larvae from 51 selectively bred\n Acropora<\/jats:italic>\n families using acute heat stress assays (35.5\u00b0C) then modelled larval survival against 20 satellite\u2010derived SST predictors (1985\u20132022) using boosted regression trees (BRT) to predict the spatial distribution of thermally resilient coral offspring along Ningaloo World Heritage Reef (East Indian Ocean). BRT models had an AUC of 0.67 (\u00b10.01 SE) and revealed that thermal anomaly frequency, cumulative heat stress and temperature variability, particularly diurnal temperature range, most strongly predicted larval survival (37.2%, 22.7% and 21.7%, respectively). Survival peaked at thermal stress of 1.14\u00b0C \u2013weeks (Degree Heating Weeks) and variability of daily temperature range of ~1\u00b0C day\n \u22121<\/jats:sup>\n highlighting potential ecological thresholds in larval survival in this area. 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J. H.","year":"2020","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-024-03221-3"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43017-021-00214-3"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.243344"},{"key":"e_1_2_10_85_1","unstructured":"Wickham H.2024.\u201cR Package \u2018ggplot2\u2019 (Version 3.5.1).\u201dhttps:\/\/cran.r\u2010project.org\/web\/packages\/ggplot2\/ggplot2.pdf."},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2105076119"}],"container-title":["Global Change Biology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gcb.70992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/gcb.70992","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gcb.70992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:22:35Z","timestamp":1787156555000},"score":7.5654783,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gcb.70992"}},"issued":{"date-parts":[[2026,7]]},"references-count":85,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/gcb.70992"],"URL":"https:\/\/doi.org\/10.1111\/gcb.70992","archive":["Portico"],"ISSN":["1354-1013","1365-2486"],"issn-type":[{"value":"1354-1013","type":"print"},{"value":"1365-2486","type":"electronic"}],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70992"},{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:06:15Z","timestamp":1777421175734,"version":"3.51.4"},"reference-count":5,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T00:00:00Z","timestamp":1448236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1177\/1060028015617278","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T21:23:41Z","timestamp":1448313821000},"page":"155-156","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Stability Studies of Extemporaneously Compounded Clobazam Oral Suspension"],"prefix":"10.1177","volume":"50","author":[{"given":"Ei Mon Phyo","family":"Lwin","sequence":"first","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ellis","sequence":"additional","affiliation":[{"name":"SA Pharmacy, Women\u2019s and Children\u2019s Hospital Campus, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunmei","family":"Song","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Turner","sequence":"additional","affiliation":[{"name":"SA Pharmacy, Women\u2019s and Children\u2019s Hospital Campus, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Garg","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,11,23]]},"reference":[{"key":"bibr1-1060028015617278","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2011.06.007"},{"key":"bibr2-1060028015617278","volume-title":"Clobazam. Monographs: Medicinal and Pharmaceutical Substances","volume":"1","author":"British Pharmacopoeia","year":"2013"},{"key":"bibr3-1060028015617278","volume-title":"Clobazam Oral Suspension, Formulated Preparations: Specific Monographs","volume":"3","author":"British Pharmacopoeia","year":"2013"},{"key":"bibr4-1060028015617278","volume-title":"Remington: The Science and Practice of Pharmacy","author":"Allen LV","year":"2012","edition":"22"},{"key":"bibr5-1060028015617278","volume-title":"Guidance on Therapeutic Goods Order No. 77: Microbiological standards for medicines","author":"Therapeutic Goods Administration","year":"2008"}],"container-title":["Annals of Pharmacotherapy"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028015617278","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1060028015617278","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028015617278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:16:05Z","timestamp":1777374965000},"score":7.5652637,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1060028015617278"}},"issued":{"date-parts":[[2015,11,23]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1177\/1060028015617278"],"URL":"https:\/\/doi.org\/10.1177\/1060028015617278","ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"published":{"date-parts":[[2015,11,23]]}},{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:10:32Z","timestamp":1785514232875,"version":"3.56.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Vasc Access"],"published-print":{"date-parts":[[2021,9]]},"abstract":"\n Background:<\/jats:title>\n Arteriovenous fistula (AVF) management for haemodialysis (HD) is one of the most challenging aspects of clinical care. A successful cannulation outcome when an AVF or arteriovenous graft (AVG) is used for the first time can be influenced by many factors, including access maturity, staff skill, and patient factors. This study examined AVF\/AVG outcomes at initiation of HD across two major metropolitan public hospitals.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Electronic medical records were reviewed to collect data retrospectively for a cohort of all newly commencing ESRD HD starts during 2018 to identify cannulation outcomes in the first 6\u2009weeks.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Of the 117 patients included, AVG use was low (5%). Twenty-four percent of patients required a surgical intervention to salvage a poorly functioning AVF prior to commencing HD. About 32.5% of the cohort had an uneventful start with all successful cannulations. For the remainder of the cohort the number of treatments with unsuccessful cannulation ranged from 1 to 4 or more. About 36% required a surgical intervention for a poorly functioning AVF after commencing HD. Commencing HD with a CVC is associated with a lower likelihood of subsequent successful cannulation ( p\u2009<\u20090.001).<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Even in experienced centres, a subset of patients experienced complicated cannulation in the first 6\u2009weeks of HD. Several areas of improvement could be considered for these patients; timely referral for access creation, post-operative surveillance to ensure AVF maturation inclusive of duplex ultrasonography, gentle induction using small gauge needles and low blood flows, and consideration of a single needle HD initiation pathway.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/1129729820954717","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T04:12:33Z","timestamp":1599797553000},"page":"726-732","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["\u201cOutcomes of arteriovenous fistulae cannulation in the first 6\u2009weeks of use: A retrospective multicenter observational study\u201d"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1593-4722","authenticated-orcid":false,"given":"Kathleen","family":"Hill","sequence":"first","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunyan","family":"Xu","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashleigh","family":"Jaensch","sequence":"additional","affiliation":[{"name":"Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Esterman","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Le Leu","sequence":"additional","affiliation":[{"name":"Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia"},{"name":"Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie","family":"Childs","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Juneja","sequence":"additional","affiliation":[{"name":"Flinders Medical Centre, Bedford Park, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpanjali","family":"Jesudason","sequence":"additional","affiliation":[{"name":"Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia"},{"name":"Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"bibr1-1129729820954717","volume-title":"Annual report","author":"Australia and New Zealand Dialysis and Transplant Registry","year":"2018"},{"issue":"3","key":"bibr2-1129729820954717","first-page":"126","volume":"9","author":"Hill KE","year":"2013","journal-title":"Ren Soc Australas J"},{"key":"bibr3-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12132"},{"key":"bibr4-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000109668.05157.05"},{"key":"bibr5-1129729820954717","unstructured":"Kidney Health Australia. Caring for Australians with renal impairment, www.cari.org.au (2008, accessed 1 May 2020)."},{"key":"bibr6-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.02.002"},{"key":"bibr7-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx278"},{"key":"bibr8-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.10.027"},{"key":"bibr9-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00724.x"},{"key":"bibr10-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx122"},{"key":"bibr11-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006030190"},{"key":"bibr12-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016121355"},{"issue":"2","key":"bibr13-1129729820954717","first-page":"78","volume":"11","author":"Schoch M","year":"2015","journal-title":"Ren Soc Australas J"},{"key":"bibr14-1129729820954717","doi-asserted-by":"publisher","DOI":"10.5301\/jva.5000674"},{"key":"bibr15-1129729820954717","doi-asserted-by":"publisher","DOI":"10.5301\/jva.5000210"},{"key":"bibr16-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1177\/2054358119843139"},{"key":"bibr17-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs415"},{"key":"bibr18-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12145"},{"key":"bibr19-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1053\/j.tvir.2016.11.001"},{"key":"bibr20-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.12.001"},{"key":"bibr21-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1177\/1129729819869093."},{"key":"bibr22-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw194.31"},{"key":"bibr23-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1159\/000363049"},{"key":"bibr24-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1080\/08860220902779764"},{"key":"bibr25-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1159\/000113008"},{"issue":"2","key":"bibr26-1129729820954717","first-page":"23","volume":"19","author":"Wilson B","year":"2009","journal-title":"CANNT J"},{"key":"bibr27-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2010.01.021"},{"key":"bibr28-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017111225"},{"key":"bibr29-1129729820954717","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2006.11.019"},{"issue":"4","key":"bibr30-1129729820954717","first-page":"28","volume":"25","author":"Marticorena R","year":"2015","journal-title":"CANNT J"}],"container-title":["The Journal of Vascular Access"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1129729820954717","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1129729820954717","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1129729820954717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:16:59Z","timestamp":1777691819000},"score":7.565257,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1129729820954717"}},"issued":{"date-parts":[[2020,9,11]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1177\/1129729820954717"],"URL":"https:\/\/doi.org\/10.1177\/1129729820954717","ISSN":["1129-7298","1724-6032"],"issn-type":[{"value":"1129-7298","type":"print"},{"value":"1724-6032","type":"electronic"}],"published":{"date-parts":[[2020,9,11]]}},{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T05:37:56Z","timestamp":1781933876622,"version":"3.54.5"},"reference-count":34,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2014,4,10]]},"published-print":{"date-parts":[[2014,5]]},"abstract":"\n Objectives<\/jats:title>\n We examined differentials in short-term (30-day mortality) and 1-year mortality (in 30-day survivors) following index (first-ever) hospitalisation for heart failure (HF), between rural and metropolitan patients resident in Western Australia.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A population-based cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Hospitalised patients in Western Australia, Australia.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Index patients aged 20\u201384\u2005years with a first-ever hospitalisation for HF between 2000 and 2009 (with no prior admissions for HF in previous 10\u2005years), identified using the Western Australia linked health data.<\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n 30-day and 1-year all-cause mortality (in 30-day survivors) following index admission for HF.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 17\u2005379 index patients with HF identified, 25.9% (4499) were from rural areas. Rural patients were significantly younger at first HF hospitalisation than metropolitan patients. Aboriginal patients comprised 1.9% of metropolitan and 17.2% of rural patients. Despite some statistical differences, the prevalence of antecedents including ischaemic heart disease, hypertension, diabetes and chronic kidney disease was high (>20%) in both subpopulations. After adjusting for age only, patients from rural areas had a higher risk of 30-day death (OR 1.16 (95% CI 1.01 to 1.33)) and 1-year death in 30-day survivors (HR 1.11 (95% CI 1.01 to 1.23)). These relative risk estimates increased and remained significant after further progressive adjustments for Aboriginality, socioeconomic status, insurance status, emergency presentation, individual comorbidities and revascularisation with OR 1.25 (1.06 to 1.48) for 30-day mortality and HR 1.13 (1.02 to 1.27) for 1-year mortality. The addition of the weighted Charlson index to the 30-day model improved the \u2018c\u2019 statistic (under the receiver operating characteristic curve) from 0.656 (using a variation of administrative claims model) to 0.714.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Remoteness and variable access to healthcare can cause important disparities in health outcomes. Rural patients with HF in Western Australia have poorer risk-adjusted outcomes compared with metropolitan patients. This finding has important implications for chronic disease management and provision of health services in rural Australia.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2013-004724","type":"journal-article","created":{"date-parts":[[2014,5,2]],"date-time":"2014-05-02T23:03:15Z","timestamp":1399071795000},"page":"e004724","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":36,"title":["Rural\u2013urban differentials in 30-day and 1-year mortality following first-ever heart failure hospitalisation in Western Australia: a population-based study using data linkage"],"prefix":"10.1136","volume":"4","author":[{"given":"Tiew-Hwa Katherine","family":"Teng","sequence":"first","affiliation":[{"name":"Western Australian Centre for Rural Health, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith M","family":"Katzenellenbogen","sequence":"additional","affiliation":[{"name":"Western Australian Centre for Rural Health, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Hung","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital Unit, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Knuiman","sequence":"additional","affiliation":[{"name":"School of Population Health, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M","family":"Sanfilippo","sequence":"additional","affiliation":[{"name":"School of Population Health, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Geelhoed","sequence":"additional","affiliation":[{"name":"School of Population Health, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hobbs","sequence":"additional","affiliation":[{"name":"School of Population Health, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra C","family":"Thompson","sequence":"additional","affiliation":[{"name":"Western Australian Centre for Rural Health, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2014,5,2]]},"reference":[{"key":"2025101810380198000_4.5.e004724.1","unstructured":"Australian Institute of Health and Welfare. 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Rural, regional and remote health: a guide to remoteness classification. Canberra: ACT, 2004. Cat no. PHE 53."},{"key":"2025101810380198000_4.5.e004724.16","unstructured":"Geographic Information Systems EB, Public Health Division. Department of Health. Health geographical classification, version 4.0. I. Perth, WA: Department of Health, 2013."},{"key":"2025101810380198000_4.5.e004724.17","unstructured":"Australian Bureau of Statistics. Information paper: census of population and housing\u2014socio-economic indexes for areas, Australia. Canberra: ABS, 2003. Cat no. 2033.055.001."},{"key":"2025101810380198000_4.5.e004724.18","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"2025101810380198000_4.5.e004724.19","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(93)90103-8"},{"key":"2025101810380198000_4.5.e004724.20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.611194"},{"key":"2025101810380198000_4.5.e004724.21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.5694\/j.1326-5377.2006.tb00690.x","article-title":"Guidelines for the prevention, detection and management of people with chronic heart failure in Australia 2006","volume":"185","author":"Krum","year":"2006","journal-title":"Med J Aust"},{"key":"2025101810380198000_4.5.e004724.22","doi-asserted-by":"crossref","first-page":"486","DOI":"10.5694\/j.1326-5377.2007.tb01014.x","article-title":"Improving rural and remote health","volume":"186","author":"Wakerman","year":"2007","journal-title":"Med J Aust"},{"key":"2025101810380198000_4.5.e004724.23","first-page":"1795","article-title":"Type 2 diabetes, cardiovascular disease and the utilisation of primary care in urban and regional settings","volume":"11","author":"Unger","year":"2011","journal-title":"Rural Remote Health"},{"key":"2025101810380198000_4.5.e004724.24","doi-asserted-by":"crossref","first-page":"441","DOI":"10.5694\/j.1326-5377.2007.tb00993.x","article-title":"Rural and urban differentials in primary care management of chronic heart failure: new data from the CASE study","volume":"186","author":"Clark","year":"2007","journal-title":"Med J Aust"},{"key":"2025101810380198000_4.5.e004724.25","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.10.1067"},{"key":"2025101810380198000_4.5.e004724.26","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e328334ea56"},{"key":"2025101810380198000_4.5.e004724.27","first-page":"17","article-title":"Health information system linkage and coordination are critical for increasing access to secondary prevention in Aboriginal health: a qualitative study","volume":"18","author":"Digiacomo","year":"2010","journal-title":"Qual Prim Care"},{"key":"2025101810380198000_4.5.e004724.28","doi-asserted-by":"publisher","DOI":"10.1071\/AH09803"},{"key":"2025101810380198000_4.5.e004724.29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1743-8462-6-29","article-title":"Are the processes recommended by the NHMRC for improving cardiac rehabilitation (CR) for Aboriginal and Torres Strait Islander people being implemented?: an assessment of CR services across Western Australia","volume":"6","author":"Thompson","year":"2009","journal-title":"Aust N Z Health Policy"},{"key":"2025101810380198000_4.5.e004724.30","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003203"},{"key":"2025101810380198000_4.5.e004724.31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1071\/AH040119","article-title":"The effects of increased private health insurance: a review of the evidence","volume":"28","author":"Hindle","year":"2004","journal-title":"Aust Health Rev"},{"key":"2025101810380198000_4.5.e004724.32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1440-1584.2012.01314.x","article-title":"Complex impact of remoteness on the incidence of myocardial infarction in Aboriginal and non-Aboriginal people in Western Australia","volume":"20","author":"Katzenellenbogen","year":"2012","journal-title":"Aust J Rural Health"},{"key":"2025101810380198000_4.5.e004724.33","doi-asserted-by":"crossref","unstructured":"Gausia K Katzenellenbogen JM Sanfilippo FM . Evidence-based prescribing of drugs for secondary prevention of acute coronary syndrome in Aboriginal and non-Aboriginal patients admitted to Western Australian hospitals. Intern Med J 2014 ;44:353\u201361.","DOI":"10.1111\/imj.12375"},{"key":"2025101810380198000_4.5.e004724.34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.5694\/j.1326-5377.2010.tb03528.x","article-title":"The effect of evidence-based medication use on long-term survival in patients hospitalized for heart failure in Western Australia","volume":"192","author":"Teng","year":"2010","journal-title":"Med J Aust"}],"container-title":["BMJ Open"],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2013-004724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T17:38:12Z","timestamp":1760809092000},"score":7.565257,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2013-004724"}},"issued":{"date-parts":[[2014,5]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,2]]},"published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1136\/bmjopen-2013-004724"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2013-004724","ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"published":{"date-parts":[[2014,5]]}},{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:03:13Z","timestamp":1779962593747,"version":"3.53.1"},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2026,5]]},"abstract":"Abstract<\/jats:title>\n \n Despite increasing utilisation of brachytherapy for pancreatic cancer, literature on its histopathological effect is sparse. We evaluated the histopathological response and distribution of phosphorus\u201032 (\n 32<\/jats:sup>\n P) microparticles in resected locally advanced pancreatic cancer (LAPC). Distribution was confined to tumour tissue, maximising therapeutic effect whilst minimising systemic and peri\u2010tumour exposure and potentially permitting optimisation of dosing and implantation strategies.\n <\/jats:p>","DOI":"10.1111\/pin.70131","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:32:18Z","timestamp":1779082338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histopathological Examination of Pancreatectomy Specimens From Patients With Locally Advanced Pancreatic Adenocarcinoma Following Endoscopic Ultrasound\u2010Guided Phosphorus\u201032 (\n 32<\/sup>\n P) Implantation and Chemotherapy"],"prefix":"10.1111","volume":"76","author":[{"given":"A. H.","family":"Lim","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ruszkiewicz","sequence":"additional","affiliation":[{"name":"Surgical Pathology, SA Pathology Adelaide South Australia Australia"},{"name":"Centre of Cancer Biology University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Rodgers","sequence":"additional","affiliation":[{"name":"ClinPath Pathology Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Thomson","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. L.","family":"Neo","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Singhal","sequence":"additional","affiliation":[{"name":"Oncology, Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bartholomeusz","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. K.","family":"Rayner","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Tse","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1270-5441","authenticated-orcid":false,"given":"N. Q.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2008.0596"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(96)00123-0"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2021.100356"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1353-0941"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2025.04.054"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.igie.2024.06.005"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16193412"}],"container-title":["Pathology International"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.70131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pin.70131","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.70131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:14:15Z","timestamp":1779959655000},"score":7.565009,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.70131"}},"issued":{"date-parts":[[2026,5]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/pin.70131"],"URL":"https:\/\/doi.org\/10.1111\/pin.70131","archive":["Portico"],"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70131"},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:33:34Z","timestamp":1753886014684,"version":"3.41.2"},"reference-count":0,"publisher":"American Physiological Society","issue":"S1","content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiology"],"published-print":{"date-parts":[[2023,5]]},"abstract":" The typical action of dopamine at the dopamine 2 receptor (D2R) on CNS neurons is inhibition, an effect mediated via G\u03b1i\/o through GIRK channels. However, at two sites, autonomic preganglionic neurons in the lumbosacral spinal cord, and in the lateral hypothalamus, dopamine causes neuronal excitation through D2R. At both sites, dopamine neurons that are excited by dopamine express the ghrelin receptor, GHSR. Ghrelin is absent from the lateral hypothalamus and spinal cord, and it has been proposed that GHSR may modulate D2R signaling by the formation of heterodimers.In lumbrosacral spinal cord neurons of the defecation centre, D2R and GHSR agonists applied successively were both excitatory. Antagonism of GHSR at these neurons blocked the excitatory effect of DR2 stimulation, which was also blocked by depletion of intracellular calcium (iCa2+). We further investigated this interaction in recombinant cultured cells. In CHO cells expressing D2R, dopamine agonists had almost no effect on iCa2+, whereas in the presence of GHSR, D2R coupling to iCa2+ was observed in response to nanomolar dopamine. The elevation of iCa2+ by dopamine in D2R\/GHSR cells was reduced by either D2R or GHSR antagonism, but the effect of a GHSR agonist was reduced only by GHSR antagonism. D2R coupling to iCa2+ in the presence of GHSR was dependent on both G\u03b1q and G\u03b1i\/o, whereas ghrelin agonist coupling was dependent only on G\u03b1q. D2R mediated effects on cAMP were dependent only on G\u03b1i\/o and were not effected by GHSR antagonism. D2R and GHSR in the membranes of CHO cells, revealed by fluorescent ligands, moved independently when tracked at high resolution in real time and, using fluorescent lifetime imaging, individual labelled DR2 sites were not in close enough proximity to detect resonance energy transfer (no detectable FRET). Consistent with coupling being via downstream crosstalk, no detectable DR2 dependent iCa2+ was evident in cells expressing the GHSR \u2013 A204E mutant, which lacks constitutive activity. The DR2-dependent iCa2+ increase was restored in these cells using subthreshold pre-stimulation with ghrelin. In native neurons of the defecation center, inward currents in response to D2R agonism were blocked by U73122, an inhibitor of PLC\u03b2. Together this data indicates that dopamine-mediated excitation was dependent on GHSR, PLC\u03b2 and iCa2+, in both native and recombinant cells. We conclude that co-expression of GHSR causes augmentation of agonist-induced, D2R-mediated PLC\u03b2 activation and store Ca2+ release in recombinant cells and in a population of autonomic preganglionic neurons. D2R mediated excitation in D2R\/GHSR cells is both G\u03b1i\/o and G\u03b1q\/11 dependent, but does not require receptor dimerisation. Our findings reveal a novel interaction between GPCRs, in a physiologically relevant system, that does not require direct receptor interaction and has broad implications for recoding of metabotropic neurotransmitter responses via modulation through other GPCRs. <\/jats:p> NHMRC grant, APP2012657, to SGBF <\/jats:p> This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process. <\/jats:p>","DOI":"10.1152\/physiol.2023.38.s1.5731818","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T14:52:22Z","timestamp":1685371942000},"update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Modulation of dopamine's effect at dopamine 2 receptors (D2R) mediated by association with the ghrelin receptor, GHSR"],"prefix":"10.1152","volume":"38","author":[{"given":"John","family":"Furness","sequence":"first","affiliation":[{"name":"University of Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhad","family":"Dehkhoda","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Whitfield","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Fothergill","sequence":"additional","affiliation":[{"name":"Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desye","family":"Misgenaw","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Ringuet","sequence":"additional","affiliation":[{"name":"Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Furness","sequence":"additional","affiliation":[{"name":"Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Physiology"],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T14:53:25Z","timestamp":1685372005000},"score":7.56474,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physiol.2023.38.S1.5731818"}},"issued":{"date-parts":[[2023,5]]},"references-count":0,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1152\/physiol.2023.38.S1.5731818"],"URL":"https:\/\/doi.org\/10.1152\/physiol.2023.38.s1.5731818","ISSN":["1548-9213","1548-9221"],"issn-type":[{"type":"print","value":"1548-9213"},{"type":"electronic","value":"1548-9221"}],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2023-05-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5731818"},{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:41:39Z","timestamp":1767897699668,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"S10","license":[{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2020,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Rates of dementia and cognitive impairment in Australian Aboriginal and Torres Strait Islander populations are 3\u20105 times higher than in the overall population. In addition, under\u2010detection of these conditions has been consistently confirmed, particularly in primary care. A national co\u2010design project called the Let\u2019s CHAT (Community Health Approach To) Dementia aims to optimise detection rates and management of dementia and cognitive impairment in Indigenous primary care contexts. This will occur through the co\u2010development of a model of care, and outcome measures include data profiling the dementia risk of older Indigenous persons and current management of patients with confirmed or suspected cognitive impairment or dementia<\/jats:p><\/jats:sec>Method<\/jats:title>Six\u2010monthly medical record audits of patients aged 50 and over recording: basic demographic information, presence of dementia risk factors, current care practices in relation to dementia and co\u2010morbid conditions of ageing.<\/jats:p><\/jats:sec>Result<\/jats:title>Audits were conducted on patients (n=1675) in 12 primary health services across Australia. The mean age of patients was 60.3 (8.3). The top ten risk factors documented overall were: hypertension (50.9%), polypharmacy (46.7%), current smoking (43%), diabetes (42.9%), dyslipidaemia (41.1%), obesity (35%), depression (30%), mental health concerns (25.9%) cardiovascular disease (25.6.%) and low physical activity (19.1%), but there was some inter\u2010service variation in risk factor profiles. Documented evidence of health service assessment for, and investigation of, cognitive impairment was limited. Use and type of diagnostic tools varied widely between services (e.g. MMSE used with 0.6%\u201045.9% of sample, KICA (culturally appropriate cognitive assessment tool) used with 0.0%\u20105.0% of sample). Diagnoses of dementia and cognitive impairment (combined = 3.8%) are well below known prevalence rates in these populations (\u223c20%), although there is variation from service to service (range = 0.8% \u20108.9%).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The audit data confirm low rates of detection and low levels of assessment activity for cognitive impairment and dementia in Indigenous primary care contexts, while the population displays a high risk for developing these conditions. These findings underscore the need for more focus on detection activities in primary health care, as well as reinforcing the importance of preventive health care strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.041319","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T14:48:57Z","timestamp":1607352537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Let\u2019s CHAT \u2013 Dementia: Primary care model of care to optimise detection and management of dementia in Aboriginal and Torres Strait Islander older people: Determination of the risk factor profile in this population"],"prefix":"10.1002","volume":"16","author":[{"given":"Jo\u2010Anne","family":"Hughson","sequence":"first","affiliation":[{"name":"University of Melbourne Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Flicker","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Smith","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Bradley","sequence":"additional","affiliation":[{"name":"University of Melbourne Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Belfrage","sequence":"additional","affiliation":[{"name":"University of Melbourne Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Strivens","sequence":"additional","affiliation":[{"name":"James Cook University Cairns Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Bessarab","sequence":"additional","affiliation":[{"name":"The University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Atkinson","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kylie","family":"Radford","sequence":"additional","affiliation":[{"name":"University of New South Wales Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah G","family":"Russell","sequence":"additional","affiliation":[{"name":"James Cook University Cairns Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Quigley","sequence":"additional","affiliation":[{"name":"James Cook University Cairns Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Allan","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roslyn","family":"Malay","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kylie","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda","family":"Ducker","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"LoGiudice","sequence":"additional","affiliation":[{"name":"The University of Melbourne Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,7]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.041319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.041319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:11:54Z","timestamp":1759878714000},"score":7.563963,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.041319"}},"subtitle":["Epidemiology \/ Risk and protective factors in MCI and dementia"],"issued":{"date-parts":[[2020,12]]},"references-count":0,"journal-issue":{"issue":"S10","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/alz.041319"],"URL":"https:\/\/doi.org\/10.1002\/alz.041319","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"2020-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e041319"},{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:53:12Z","timestamp":1787014392936,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T00:00:00Z","timestamp":1626566400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["634486"],"award-info":[{"award-number":["634486"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2021,7]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Pain is a growing public health problem associated with significant health and functional implications. Limited data exist for Aboriginal Australians.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n To describe the prevalence, severity and sites of pain, analgesic use and associated factors, including depression and disability, in remote\u2010living Aboriginal Australians.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Cross\u2010sectional study of 263 Aboriginal Australians aged \u226545\u2009years from six remote Indigenous communities and the town of Derby in the Kimberley region of Western Australia between 2011 and 2013. Pain was assessed using a culturally adapted pain scale. Factors associated with pain were investigated with binary logistic regression.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n One hundred and seventy (64.6%) participants reported having pain and 53 (20.2%) reported persistent pain. Of those reporting pain, 61 (35.9%) rated it as moderate and 70 (41.2%) as severe. The most common sites of pain were back and knee, and 38 (22.4%) participants with pain indicated three or more sites of pain. Only 70 (41.2%) participants with pain were on some type of analgesic medication. After adjustment, poor vision (odds ratio (OR) =\u20092.21; 95% confidence interval (CI) 1.22\u20134.00), hypertension (OR\u00a0=\u00a01.89; 95% CI 1.03\u20133.45) and heart problems (OR\u00a0=\u00a02.05; 95% CI 1.01\u20134.14) were associated with pain. Higher depression scores were associated with more persistent pain, but pain was not significantly associated with clinically relevant depressive symptoms, or requiring assistance with two or more personal and\/or instrumental activities of daily living.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n High levels of pain were reported, although the prevalence of persistent pain was comparable to the general population. Identifying risk factors, improving pain recognition and assessment and evaluating culturally tailored management approaches should be a priority.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/imj.14870","type":"journal-article","created":{"date-parts":[[2020,5,2]],"date-time":"2020-05-02T10:41:20Z","timestamp":1588416080000},"page":"1092-1100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence and sites of pain in remote\u2010living older Aboriginal Australians, and associations with depressive symptoms and disability"],"prefix":"10.1111","volume":"51","author":[{"given":"Aaron","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine Austin Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zo\u00eb","family":"Hyde","sequence":"additional","affiliation":[{"name":"Western Australian Centre for Health and Ageing University of Western Australia Perth Western Australia Australia"},{"name":"School of Medicine University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Smith","sequence":"additional","affiliation":[{"name":"Western Australian Centre for Health and Ageing University of Western Australia Perth Western Australia Australia"},{"name":"School of Medicine University of Western Australia Perth Western Australia Australia"},{"name":"Centre for Aboriginal Medical and Dental Health University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Flicker","sequence":"additional","affiliation":[{"name":"Western Australian Centre for Health and Ageing University of Western Australia Perth Western Australia Australia"},{"name":"School of Medicine University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Rural Clinical School of WA University of Western Australia Perth Western Australia Australia"},{"name":"Broome Regional Aboriginal Medical Service Broome Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Skeaf","sequence":"additional","affiliation":[{"name":"Western Australian Centre for Health and Ageing University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roslyn","family":"Malay","sequence":"additional","affiliation":[{"name":"Western Australian Centre for Health and Ageing University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"LoGiudice","sequence":"additional","affiliation":[{"name":"Western Australian Centre for Health and Ageing University of Western Australia Perth Western Australia Australia"},{"name":"Aged Care Melbourne Health and University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,18]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Chronic Pain \u2013 A Major Issue in Rural Australia","author":"National Rural Health Alliance","year":"2013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S105892"},{"key":"e_1_2_7_4_1","volume-title":"Australia's Health 2014","author":"Australian Institute of Health and Welfare (AIHW)","year":"2014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5172\/conu.2006.22.2.218"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2217\/pmt.13.18"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3402\/ijch.v75.32798"},{"key":"e_1_2_7_8_1","volume-title":"The Health and Welfare of Australia's Aboriginal and Torres Strait Islander People: 2015","author":"Australian Institute of Health and Welfare (AIHW)","year":"2015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajag.12332"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2010.02332.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23493"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajr.12185"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2012.00128.x"},{"key":"e_1_2_7_14_1","volume-title":"Aboriginal and Torres Strait Islander Patient Care Guideline","author":"Queensland Health","year":"2014"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.01.009"},{"key":"e_1_2_7_16_1","unstructured":"CleelandCS. Brief Pain Inventory (Short Form). 1991 [cited 2019 Apr 28]. Available from URL:http:\/\/www.mdanderson.org\/documents\/Departments-and-Divisions\/Symptom-Research\/BPI-SF_English-24h_Original_SAMPLE.pdf"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094983"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50226"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12542"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00355-9"},{"key":"e_1_2_7_21_1","first-page":"103","volume-title":"Epidemiology of Pain","author":"Helme R","year":"1999"},{"key":"e_1_2_7_22_1","first-page":"U1629","article-title":"Musculoskeletal pain in the adult New Zealand population: prevalence and impact","volume":"118","author":"Taylor W","year":"2005","journal-title":"N Z Med 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Rheumatol"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12195"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12820"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja16.00066"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2018.02.001"},{"key":"e_1_2_7_33_1","first-page":"557","article-title":"Issues with prescribed medications in Aboriginal communities: Aboriginal health workers' perspectives","volume":"6","author":"Hamrosi K","year":"2006","journal-title":"Rural Remote 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Journal"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.14870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.14870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.14870","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.14870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T07:33:34Z","timestamp":1693294414000},"score":7.563741,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.14870"}},"issued":{"date-parts":[[2021,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/imj.14870"],"URL":"https:\/\/doi.org\/10.1111\/imj.14870","archive":["Portico"],"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"2019-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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Urology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.juro.2017.02.2576","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T18:14:22Z","timestamp":1491243262000},"source":"Crossref","is-referenced-by-count":0,"title":["MP83-08 COMBINATION OF METFORMIN AND SODIUM VALPROATE FOR PROSTATE CANCER: A RAPID APPROACH FROM BENCH TO CLINICAL TRIAL."],"prefix":"10.1097","volume":"197","author":[{"given":"Linh N.K.","family":"Tran","sequence":"first","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganessan","family":"Kichenadasse","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca J.","family":"Ormsby","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine L.","family":"Morel","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Butler","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret M.","family":"Centenera","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela J.","family":"Sykes","sequence":"additional","affiliation":[{"name":"Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534717340429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534717340429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2017.02.2576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:26:17Z","timestamp":1651209977000},"score":7.56357,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2017.02.2576"}},"issued":{"date-parts":[[2017,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1016\/j.juro.2017.02.2576"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2017.02.2576","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2017,4]]}},{"indexed":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T19:40:49Z","timestamp":1656358849317},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"19_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2014,10,1]]},"abstract":"Abstract<\/jats:title>\n Breast cancer is one of the most common malignancies globally. It accounts for approximately 15% of cancer-related deaths in Australian women. The orphan nuclear receptor liver receptor homolog-1 (LRH-1) promotes increased cell proliferation, motility and invasion in breast cancer cell lines. Additionally, high LRH-1 expression in human breast cancers is positively associated with estrogen receptor alpha status and aromatase activity. However, the role of LRH-1 in tumour growth is not well understood. Therefore, we aimed to generate a doxycycline (dox)-inducible mammary epithelial specific LRH-1 knock-in mouse in order to define the role of LRH-1 in mammary epithelial proliferation in vivo. In addition, the Dimethylbenz(a)anthracene (DMBA) induced mammary tumour model was utilized with the LRH-1 transgenic mice to determine the role LRH-1 plays in promoting mammary carcinogenesis. Given clear in vitro roles for LRH-1 in breast cancer cell proliferation, we hypothesise LRH-1 stimulates mouse mammary epithelial cell proliferation and promotes DMBA-mediated mammary tumorigenesis.<\/jats:p>\n We demonstrate increase in proliferation markers Ki-67, PCNA and PH3 immunoreactivity in luminal epithelial cells of dox-treated animals indicating that LRH-1 plays a role in mammary cell proliferation in vivo. In DMBA treated animals, we observed a five-fold increase of dense pre-neoplastic epithelial foci (p=0.0267), and a four-fold increase in microscopic lesions in dox-treated animals (p=0.0003). We also demonstrated that LRH-1 over-expression significantly reduced breast tumour-free survival in the transgenic DMBA model (no dox n=11; dox n=12, Mantel-Cox test p=0.0375). Tumour penetrance in DMBA animals not treated with dox was 9% (out of eleven animals) versus 25.0% (out of twelve animals) in the dox treated cohort.<\/jats:p>\n LRH-1 is known synergise with \u03b2-catenin to induce cyclin D1\/E1 mediated cell proliferation in vitro. We analysed transcript levels of cyclin D1\/E1 and show a significant increase in dox treated animals with or without DMBA. Finally, we demonstrate an increase in the oncogene \u03b2-catenin nuclear localisation in the dox treated animals with or without DMBA. Taken together, these data suggest that LRH-1 increases incidence of DMBA-induced mammary tumours. Further analyses on mechanism(s) mediated by LRH-1 are warranted to fully understand its role in mammary tumorigenesis.<\/jats:p>\n Note: This abstract was not presented at the meeting.<\/jats:p>\n Citation Format: Kyren A. Lazarus, Kristy Brown, Morag Young, Jason Cain, Samantha Jayasekara, Rhiannon Coulson, Neil Watkins, Colin Clyne, Ashwini Chand. Liver receptor homologue-1 increases incidence of DMBA-induced mammary tumors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. 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The average time taken to run CCP includes 2 days library preparation; 4 hour sequencing run, 8 hours primary analysis for generating read alignments and sequencing files. The Ampliseq protocol required modifications with respect to template input amount and cycling parameters in order to increase the fidelity of library preparation. Limitations in sequencing depth and read qualities with the current technologies lend themselves to approximately 5-6 samples\/sequencing run\/day if 500x read depth per amplicon is desired.<\/jats:p>\n Days 4-6 manually curated bioinformatics against publicly available mutation databases (e.g. COSMIC, ENSEMBL etc.)<\/jats:p>\n Day 7 communication of results<\/jats:p>\n Molecular Pathology results<\/jats:p>\n The median age was 57, (32-84), 18 (72%) were postmenopausal. Histopathology invasive ductal 22 (84%), invasive lobular 2 (8%) metaplastic 2 (8%).<\/jats:p>\n TNM Staging: T1b 5 (19%), T1c 9 (35%) T2 12 (46%); N0 23 (88%), N1mi 1 (4%), N1a 1 (4%), N2a 1 (4%).<\/jats:p>\n Hormone receptors antibodies: ER (Roche SP1) Strong 20 (77%), Moderate 1 (4%), Weak 1 (4%), Negative 4 (15%); PR (Roche 1E2) Strong 11 (42%), Moderate 10 (38%), Weak 0 (0%), Negative 5 (19%); HER2 IHC (Ventana 4B5) Strong 1 (4%), Moderate 6 (23%), Weak 6 (23%), Negative 13 (50%); HER2 SISH (Ventana inform single probe); 1 SISH positive (mean copy number 29.6); 4 patients (15%) triple negative.<\/jats:p>\n Molecular aberrations identified included oncogenes TP53 2 (8%), PIK3CA 12 (46%) HRAS 2 (8%), AKT1 1 (4%); tumour suppressor genes MLL3 2 (8%), MSH6 1 (4%), ARID1A 1 (4%), and in the germline in tumour suppressor genes EPHB6 1 (4%) and LTK 1 (4%).<\/jats:p>\n Significant technical and bioinformatic challenges were encountered during the development of this metric study including Ampliseq protocol modification and parameter tuning for variant calling algorithm.<\/jats:p>\n In summary, many challenges face the clinical laboratory developing high throughput MPS using desktop MPS. To date this is the first publication of the new Ion Proton P1 chips in development for real-time clinical decision making. Copy-number variation (CNV), RNA-Seq, Methyl-Seq data will be available for presentation at San Antonio.<\/jats:p>\n Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-05-16.<\/jats:p>","DOI":"10.1158\/0008-5472.sabcs13-p4-05-16","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T22:26:43Z","timestamp":1408055203000},"page":"P4-05-16-P4-05-16","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract P4-05-16: Quality metric study of real-time targeted massive parallel sequencing (MPS) (ampliseq comprehensive cancer panel (CCP)) and bioinformatics in early breast cancer (EBC) using life technologies ion proton system"],"prefix":"10.1158","volume":"73","author":[{"given":"PN","family":"Mainwaring","sequence":"first","affiliation":[{"name":"Haematology & Oncology Clinics of Australia, Brisbane, Queensland, Australia; University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Pyke","sequence":"additional","affiliation":[{"name":"Haematology & Oncology Clinics of Australia, Brisbane, Queensland, Australia; 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University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Phillips","sequence":"additional","affiliation":[{"name":"Haematology & Oncology Clinics of Australia, Brisbane, Queensland, Australia; University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Francis","sequence":"additional","affiliation":[{"name":"Haematology & Oncology Clinics of Australia, Brisbane, Queensland, Australia; University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Trau","sequence":"additional","affiliation":[{"name":"Haematology & Oncology Clinics of Australia, Brisbane, Queensland, Australia; University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/73\/24_Supplement\/P4-05-16\/585731\/Abstract-P4-05-16-Quality-metric-study-of-real","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/73\/24_Supplement\/P4-05-16\/585731\/Abstract-P4-05-16-Quality-metric-study-of-real","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T09:03:15Z","timestamp":1656579795000},"score":7.5633917,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/73\/24_Supplement\/P4-05-16\/585731\/Abstract-P4-05-16-Quality-metric-study-of-real"}},"issued":{"date-parts":[[2013,12,15]]},"references-count":0,"journal-issue":{"issue":"24_Supplement","published-print":{"date-parts":[[2013,12,15]]}},"URL":"https:\/\/doi.org\/10.1158\/0008-5472.sabcs13-p4-05-16","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2013,12,15]]}},{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:10:45Z","timestamp":1773047445133,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Controlling cytomegalovirus (CMV) infection through prophylaxis or pre\u2010emptive therapy remains an important contributor to outcomes after allogeneic hematopoetic stem cell transplant (alloHCT). Predicting clinically significant CMV infection (csCMVi) after day 100 remains a challenge.<\/jats:p><\/jats:sec>Methods<\/jats:title>We examined the abilty of the QuantiFERON\u2010CMV assay (QFN\u2010CMV) at day 100 (d100) and day 150 (d150) after alloHCT to predict csCMVi after these time points, with median follow\u2010up of 3.1 years (range 1.3\u20134.3 years).<\/jats:p><\/jats:sec>Results<\/jats:title>In 46 transplants (donor seropositive (D+) recipient seronegative (R\u2010) = 12, D+R+ = 25, D\u2010R+\u00a0=\u00a09; matched related\u00a0=\u00a013, unrelated donor\u00a0=\u00a032, haploidentical\u00a0=\u00a01), for the prediction of freedom from csCMVi\u00a0>d100, QFN\u2010CMVd100 (positive compared to negative\/indeterminate) had sensitivity 62% (23\/37), specificity 100% (9\/9), positive predictive value 100% (23\/23), and negative predictive value 39% (9\/23). For the prediction of freedom from csCMVi\u00a0>d150, QFN\u2010CMVd150 (positive compared to negative\/indeterminate) had sensitivity 62% (18\/29), specificity 83% (5\/6), positive predictive value 95% (18\/19), and negative predictive value 31% (5\/16).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Positive QFN\u2010CMV at d100 and d150 strongly predicted freedom from csCMVi after these time points. QFN\u2010CMV could be utilized to predict the need for pre\u2010emptive therapy and CMV viral load monitoring after day 100 post\u2010alloHCT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tid.13786","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T05:44:10Z","timestamp":1641534250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["QuantiFERON\u2010cytomegalovirus to predict clinically significant cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"24","author":[{"given":"Grace","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Immunology Queen Elizabeth II Medical Centre Nedlands Western Australia Australia"},{"name":"Department of Immunology PathWest Laboratory Medicine Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0518-0421","authenticated-orcid":false,"given":"Peter","family":"Boan","sequence":"additional","affiliation":[{"name":"Department of Infectious diseases Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Microbiology PathWest Laboratory Medicine Western Australia Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0408-8455","authenticated-orcid":false,"given":"Duncan","family":"Purtill","sequence":"additional","affiliation":[{"name":"Department of Haematology Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Haematology PathWest Laboratory Medicine Western Australia Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4820-6406","authenticated-orcid":false,"given":"Julian","family":"Cooney","sequence":"additional","affiliation":[{"name":"Department of Haematology Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Haematology PathWest Laboratory Medicine Western Australia Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Cannell","sequence":"additional","affiliation":[{"name":"Department of Haematology Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Haematology PathWest Laboratory Medicine Western Australia Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Haematology Fiona Stanley Hospital Murdoch Western Australia Australia"},{"name":"Department of Haematology PathWest Laboratory Medicine Western Australia Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"John","sequence":"additional","affiliation":[{"name":"Department of Immunology Queen Elizabeth II Medical Centre Nedlands Western Australia Australia"},{"name":"Department of Immunology PathWest Laboratory Medicine Western Australia Nedlands Western Australia Australia"},{"name":"Institute for Immunology and Infectious Diseases (IIID), Murdoch University Western Australia Australia"},{"name":"Department of Clinical Immunology Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.09.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00203-06"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2017.01.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30107-0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706640"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw107"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2006.00199.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074744"},{"issue":"9","key":"e_1_2_9_11_1","first-page":"2365","article-title":"Cytomegalovirus (CMV) cell\u2010mediated immunity and CMV infection after allogeneic hematopoietic cell transplantation: the REACT study","volume":"71","author":"Chemaly RF","year":"2020","journal-title":"Clin Infect Dis"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw064"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix192"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13260"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12406"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2018.01.002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13220"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.229252"}],"container-title":["Transplant Infectious Disease"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.13786","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.13786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T23:15:32Z","timestamp":1693005332000},"score":7.5632954,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.13786"}},"issued":{"date-parts":[[2022,1,25]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/tid.13786"],"URL":"https:\/\/doi.org\/10.1111\/tid.13786","archive":["Portico"],"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"published":{"date-parts":[[2022,1,25]]},"assertion":[{"value":"2021-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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Criminology","doi-asserted-by":"publisher","award":["CRG27\/16-17"],"award-info":[{"award-number":["CRG27\/16-17"]}],"id":[{"id":"10.13039\/501100001072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Criminology &amp; Criminal Justice"],"published-print":{"date-parts":[[2025,4]]},"abstract":"In recent decades, Australian states and territories have introduced a raft of legislation aimed at stripping those involved in criminal activity of their ill-gotten gains. This contribution reports on a study into proceeds of crime legislation in three Australian jurisdictions: New South Wales, Western Australia and Queensland. Based on a document analysis and 40 interviews, we focus on the broader criminological aspects of how and why proceeds of crime legislation was introduced and how the legislation is experienced by those who work with it \/ are impacted by it. We then discuss the political attractiveness of such legislation in a broader law and order framework, despite its apparent limited success in achieving its stated goals.<\/jats:p>","DOI":"10.1177\/17488958221136210","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T06:03:57Z","timestamp":1668405837000},"page":"591-611","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A criminological analysis of proceeds of crime legislation in three Australian states"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6132-6184","authenticated-orcid":false,"given":"Hilde","family":"Tubex","sequence":"first","affiliation":[{"name":"The University of Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhianna","family":"Chisholm","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Tulich","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Skead","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Murray","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"e_1_3_3_2_1","unstructured":"Australian Law Reform Commission ( 1999) Confiscation that counts \u2013 A review of the Proceeds of Crime Act 1987 (No. 87). Available at: https:\/\/www.alrc.gov.au\/publication\/confiscation-that-counts-a-review-of-the-proceeds-of-crime-act-1987-alrc-report-87\/ (accessed 8 November 2021)."},{"issue":"4","key":"e_1_3_3_3_1","first-page":"191","article-title":"The disunity of sentencing and confiscation","volume":"21","author":"Bagaric M","year":"1997","unstructured":"Bagaric M (1997) The disunity of sentencing and confiscation. Criminal Law Journal 21(4): 191\u2013203.","journal-title":"Criminal Law Journal"},{"key":"e_1_3_3_4_1","first-page":"8611","article-title":"Criminal property confiscation bill 2000","author":"Barron-Sullivan D","year":"2000","unstructured":"Barron-Sullivan D (2000) Criminal property confiscation bill 2000. Hansard (WA, Legislative Assembly), 29 June, p. 8611.","journal-title":"Hansard (WA, Legislative Assembly)"},{"key":"e_1_3_3_5_1","volume-title":"Making Crime Pay: Law and Order in Contemporary American Politics","author":"Beckett K","year":"1997","unstructured":"Beckett K (1997) Making Crime Pay: Law and Order in Contemporary American Politics. New York: Oxford University Press."},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/002201839906300407"},{"key":"e_1_3_3_7_1","first-page":"1358","article-title":"Crimes (confiscation of profits) bill","author":"Berinson JM","year":"1988","unstructured":"Berinson JM (1988) Crimes (confiscation of profits) bill. Hansard (WA, Legislative Council), 21 June, p. 1358.","journal-title":"Hansard (WA, Legislative Council)"},{"key":"e_1_3_3_8_1","first-page":"2314","article-title":"Proceeds of crime bill","author":"Bowen L","year":"1987","unstructured":"Bowen L (1987) Proceeds of crime bill. Hansard (Commonwealth, House of Representatives), 30 April, p. 2314.","journal-title":"Hansard (Commonwealth, House of Representatives)"},{"key":"e_1_3_3_9_1","first-page":"17","article-title":"Noose debate goes full circle","author":"Burns A","year":"2000","unstructured":"Burns A (2000) Noose debate goes full circle. The West Australian, 17 March, p. 17.","journal-title":"The West Australian"},{"key":"e_1_3_3_10_1","first-page":"3516","article-title":"Drug trafficking (civil proceedings) bill","author":"Carr B","year":"1990","unstructured":"Carr B (1990) Drug trafficking (civil proceedings) bill. Hansard (NSW, Legislative Assembly), 16 May, pp. 3516\u20133518.","journal-title":"Hansard (NSW, Legislative Assembly)"},{"key":"e_1_3_3_11_1","volume-title":"Penal Systems: A Comparative Approach","author":"Cavadino M","year":"2006","unstructured":"Cavadino M, Dignan J (2006) Penal Systems: A Comparative Approach. London: SAGE."},{"issue":"5","key":"e_1_3_3_12_1","first-page":"263","article-title":"A man\u2019s home is his castle: Or is it? How to take houses from people without convicting them of anything: The Criminal Property Confiscation Act 2000 (WA)","volume":"28","author":"Clarke B","year":"2004","unstructured":"Clarke B (2004) A man\u2019s home is his castle: Or is it? How to take houses from people without convicting them of anything: The Criminal Property Confiscation Act 2000 (WA). Criminal Law Journal 28(5): 263\u2013286.","journal-title":"Criminal Law Journal"},{"key":"e_1_3_3_13_1","first-page":"4037","article-title":"Crimes (confiscation of profits) bill","author":"Clauson PJ","year":"1989","unstructured":"Clauson PJ (1989) Crimes (confiscation of profits) bill. 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Cheltenham: Edward Elgar."},{"key":"e_1_3_3_26_1","first-page":"131","volume-title":"Dirty Assets: Emerging Issues in the Regulation of Criminal and Terrorist Assets","author":"Goldsmith A","year":"2014","unstructured":"Goldsmith A, Gray D, Smith R (2014) Criminal Asset Recovery in Australia. In: Collin K, Walker C (eds) Dirty Assets: Emerging Issues in the Regulation of Criminal and Terrorist Assets. Farnham: Routledge, pp. 131\u2013156."},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1525\/nclr.2012.15.1.32"},{"key":"e_1_3_3_28_1","first-page":"2527","article-title":"Drug trafficking (civil proceedings) bill","author":"Greiner N","year":"1990","unstructured":"Greiner N (1990) Drug trafficking (civil proceedings) bill. 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Understanding the real\u2010world cost of therapies for each stage will become increasingly important in informing treatment selection and health policy.<\/jats:p><\/jats:sec>Methods<\/jats:title>To explore the cost of treating colorectal cancer in the modern era, data were entered onto a prospective database at four hospitals. We estimated the impact of bevacizumab by using data from J<\/jats:styled-content>uly 2009, and projected the likely impact of the recent listing of cetuximab. The utility of these data for estimating the cost\u2010effectiveness of treatment was explored.<\/jats:p><\/jats:sec>Results<\/jats:title>Cancer stage and age at diagnosis were major determinants of treatment received and the associated cost. The cost of early stage disease has not substantially changed whereas therapies such as oxaliplatin and irinotecan were significant contributors to substantial increases in stage IV disease, now $71\u2009156 per patient. Bevacizumab has added at least $10\u2009247 per patient and we estimate that cetuximab will add a further $12\u2009022. An exploratory analysis of the cost\u2010effectiveness of oxaliplatin for adjuvant therapy of stage III colon cancer suggests that this is well within the accepted range.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These data suggest that recent progress in the treatment of later stages of colorectal cancer is being achieved at significant financial cost. 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A three\u2010dimensional (3\u2010D) hydrodynamic model, ROMS (Regional Ocean Modeling System), was coupled with a four\u2010component nitrogen\u2010based biogeochemical NPZD model (Nitrogen Phytoplankton Zooplankton Detritus) to resolve the shelf circulation as well as the coupled nutrient and phytoplankton dynamics within a broad shelf region surrounding Ningaloo Reef. The simulated currents, temperatures, and chlorophyll a<\/jats:italic> concentrations generally agreed well with both the remotely sensed satellite images and observational data collected during a field experiment from September to November 2010. Scenario tests for an individual wind\u2010driven upwelling event under a variety of hypothetical physical forcing conditions showed that shelf currents and biogeochemical variables were largely a function of wind stress and stratification. However, the functional relationships derived from this single wind event could not be extrapolated to other periods of the upwelling season, due to the additional influence of 3\u2010D mesoscale processes on the shelf. The presence, intensification, and propagation of a coastal anticyclonic eddy during the study period strongly influenced the spatial and temporal variations in nutrient profiles, which in turn caused fluctuations in vertical nutrient fluxes that were largely independent of wind stress. These results emphasize that it is necessary to fully capture the 3\u2010D details of the mesoscale and submesoscale coastal dynamics to properly predict upwelling\u2010induced coastal phytoplankton dynamics in eddy\u2010intensive shelf regions such as Ningaloo Reef.<\/jats:p>","DOI":"10.1002\/2016jc011791","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T08:32:49Z","timestamp":1467016369000},"page":"4994-5016","source":"Crossref","is-referenced-by-count":10,"title":["The combined effect of transient wind\u2010driven upwelling and eddies on vertical nutrient fluxes and phytoplankton dynamics along Ningaloo Reef, Western Australia"],"prefix":"10.1029","volume":"121","author":[{"given":"Zhenlin","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Earth and Environment University of Western Australia Perth Western Australia Australia"},{"name":"UWA Oceans Institute, University of Western Australia Perth Western Australia Australia"},{"name":"ARC Centre of Excellence for Coral Reef Studies University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Lowe","sequence":"additional","affiliation":[{"name":"School of Earth and Environment University of Western Australia Perth Western Australia Australia"},{"name":"UWA Oceans Institute, University of Western Australia Perth Western Australia Australia"},{"name":"ARC Centre of Excellence for Coral Reef Studies University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Ivey","sequence":"additional","affiliation":[{"name":"UWA Oceans Institute, University of Western Australia Perth Western Australia Australia"},{"name":"School of Civil, Environmental and Mining Engineering University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangtao","family":"Xu","sequence":"additional","affiliation":[{"name":"UWA Oceans Institute, University of Western Australia Perth Western Australia Australia"},{"name":"School of Civil, Environmental and Mining Engineering University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Falter","sequence":"additional","affiliation":[{"name":"School of Earth and Environment University of Western Australia Perth Western Australia Australia"},{"name":"UWA Oceans Institute, University of Western Australia Perth Western Australia Australia"},{"name":"ARC Centre of Excellence for Coral Reef Studies University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"13","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1175\/1520-0485(1998)028<2199:MSOTLC>2.0.CO;2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1029\/2000JC900044"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pocean.2012.09.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ngeo1916"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2112\/05-0623.1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pocean.2009.07.032"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pocean.2012.10.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1357\/002224088785113478"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1256\/qj.05.105"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00338-012-0974-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1029\/2000JC900063"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-0637(01)00069-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/plankt\/22.9.1619"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1029\/94JC01894"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1175\/1520-0442(2003)016<0571:BPOASF>2.0.CO;2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1029\/2011JC007268"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1175\/JPO2730.1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01277"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csr.2007.01.002"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1029\/2000JC000768"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1029\/2005JC003298"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/2013JC009027"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1357\/002224008786176043"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsr2.2006.10.004"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-0149(85)90101-3"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ngeo1273"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcp.2007.06.016"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csr.2005.04.003"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1029\/JC095iC07p11425"},{"key":"e_1_2_7_31_1","volume-title":"Tech. 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This study validates a linear, algebraic prediction model for sea states with large directional spreading. The model decomposes observed time histories using a Fourier transform to obtain an approximate representation of the wave field using a small number of directional components. Pre-processing involves the partial removal of nonlinear harmonics by a bandpass filter followed by the attachment of a NewWave-type signal at each end of each record. The model is tested using field data measured using a small array of wave buoys deployed in the Southern Ocean off Albany, Western Australia. It shows good agreement between prediction and target time series. Aggregating and weight-averaging multiple predictions obtained with different sets of optimal representative directions improves the quality of prediction. Based on the linear propagation of representative directional Fourier components, the model is relatively robust to the presence of (unfilterable) higher harmonics and fast enough for real-time predictions.<\/jats:p>","DOI":"10.1115\/omae2023-104672","type":"proceedings-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T17:29:39Z","timestamp":1695403779000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":0,"title":["Optimised Wave-by-Wave Prediction of Spread Waves: Comparison With Field Data"],"prefix":"10.1115","author":[{"given":"Thobani","family":"Hlophe","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul H.","family":"Taylor","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi","family":"Kurniawan","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Orszaghova","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Wolgamot","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33","published-online":{"date-parts":[[2023,9,22]]},"event":{"name":"ASME 2023 42nd International Conference on Ocean, Offshore and Arctic Engineering","start":{"date-parts":[[2023,6,11]]},"sponsor":["Ocean, Offshore and Arctic Engineering Division"],"location":"Melbourne, Australia","end":{"date-parts":[[2023,6,16]]},"acronym":"OMAE2023"},"container-title":["Volume 5: Ocean Engineering"],"link":[{"URL":"https:\/\/asmedigitalcollection.asme.org\/OMAE\/proceedings-pdf\/doi\/10.1115\/OMAE2023-104672\/7041205\/v005t06a103-omae2023-104672.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/asmedigitalcollection.asme.org\/OMAE\/proceedings-pdf\/doi\/10.1115\/OMAE2023-104672\/7041205\/v005t06a103-omae2023-104672.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T17:29:41Z","timestamp":1695403781000},"score":7.5629535,"resource":{"primary":{"URL":"https:\/\/asmedigitalcollection.asme.org\/OMAE\/proceedings\/OMAE2023\/86878\/V005T06A103\/1167142"}},"issued":{"date-parts":[[2023,6,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1115\/omae2023-104672","published":{"date-parts":[[2023,6,11]]},"article-number":"V005T06A103"},{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:41:24Z","timestamp":1759956084322,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"S15","license":[{"start":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T00:00:00Z","timestamp":1703462400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2023,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Human cytomegalovirus (HCMV) is a ubiquitous infectious agent, widely distributed in human populations. Its infection has been correlated with a number of age\u2010related disorders but associations with neurocognitive decline are not seen consistently. The Tumor Necrosis Factor\u2010\u03b1 (TNF) is a cytokinine playing a key role in inflammation and TNF polymorphisms have been associated with various autoimmune diseases. In this study, we investigated the impact of TNF genotype and HCMV on age\u2010related cognitive decline.<\/jats:p><\/jats:sec>Method<\/jats:title>The study cohort consisted of 200 Caucasian Australians (aged 59\u201089 years) drawn from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. We used linear regression models to assess the effect of TNF genotype, HCMV and their interaction on a series of domain\u2010specific composite scores (Preclinical Alzheimer Cognitive Composite; PACC, Recognition, Attention Processing, Language). The models accounted for the potential effect of age, education level and Apolipoprotein E genotype.<\/jats:p><\/jats:sec>Result<\/jats:title>The interaction between HCMV and TNF genotype significantly predicted PACC (b = 5.3; SE = 2.56; p = 0.04) and Recognition scores (b = 1.9; SE = 0.78; p = 0.01). Interactions were not significant in the other domains investigated (attention processing & language).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The results suggest that the presence of TNF polymorphism, combined with HCMV infection have a protective effect against cognitive loss. Further research is needed to understand the underpinning mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.079688","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T06:14:02Z","timestamp":1703484842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined effect of persistent cytomegalovirus infection and Tumor Necrosis Factor\u2010\u03b1 Polymorphism on age\u2010related cognitive decline"],"prefix":"10.1002","volume":"19","author":[{"given":"Michael","family":"Vacher","sequence":"first","affiliation":[{"name":"Edith Cowan University, Joondalup Australia"},{"name":"Commonwealth Scientific and Industrial Research Organisation, Floreat Australia"},{"name":"Australian E\u2010Health Research Centre, CSIRO, Perth, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Lee","sequence":"additional","affiliation":[{"name":"Curtin University, Bentley, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phuongnhi","family":"Ha","sequence":"additional","affiliation":[{"name":"Curtin University, Bentley, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley","family":"Waters","sequence":"additional","affiliation":[{"name":"Curtin University, Bentley, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Laws","sequence":"additional","affiliation":[{"name":"Edith Cowan University, Joondalup, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Price","sequence":"additional","affiliation":[{"name":"Curtin University, Bentley, Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,25]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.079688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:02:01Z","timestamp":1759953721000},"score":7.562907,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.079688"}},"issued":{"date-parts":[[2023,12]]},"references-count":0,"journal-issue":{"issue":"S15","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/alz.079688"],"URL":"https:\/\/doi.org\/10.1002\/alz.079688","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"type":"print","value":"1552-5260"},{"type":"electronic","value":"1552-5279"}],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-12-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e079688"},{"indexed":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T13:41:36Z","timestamp":1656596496745},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"8_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2013,4,15]]},"abstract":"Abstract<\/jats:title>\n Tumour initiation in the TH-MYCN transgenic mouse model of neuroblastoma is characterised by transient repression of p53 stress responses in embryonal ganglionic neuroblasts, causing them to persist postnatally as cancer-prone lesions 1, 2. p53 re-activation may be a potential therapeutic strategy for removal of these lesions before they later transform in response to oncogenic stimuli. One potential target for p53 activation is the FACT protein complex which is known to inhibit p53 signalling. Here we show that high mRNA expression levels of the two FACT subunits, SSRP1 and SPT16, in human primary neuroblastoma tissue were significantly associated with poor patient outcome (p&lt;0.001) on Kaplan Meier analysis of 650 neuroblastoma patients. Both SSRP1 and SPT16 levels had a strong correlation with the level of MYCN expression, particularly in high risk MYCN-amplified neuroblastoma tissues (p&lt;0.05). Inhibition of MYCN expression by a specific siRNA, lowered SSRP1 and SPT16 expression in two neuroblastoma tumor cell lines (BE(2)C and Kelly). Alamar blue assays revealed that a chemical inhibitor of FACT, Curaxin or CBL137, potently and selectively promoted cytotoxicity in neuroblastoma cell lines as compared to non-malignant MRC5 fibroblasts (p&lt;0.001). To examine the role of FACT in MYCN-driven tumourigenesis we evaluated the effect of Curaxin on tumor initiation in TH-MYCN mice. Low micromolar Curaxin doses effectively restored normal in vitro, p53-dependent death responses to primary ganglion cells deprived of serum from neonatal TH-MYCN mice, while ganglion cultures from wild-type littermate mice were significantly more resistant to Curaxin treatment, with or without serum deprivation (p&lt;0.001). Most importantly, prophylactic Curaxin treatment of 6 day old TH-MYCN mice had a marked inhibitory effect on postnatal ganglion neuroblast persistence in vivo for both hemizygote and homozygote TH-MYCN mice, as compared to vehicle-only treated animals (p=0.01, p=0.035, respectively). Taken together, our data for the first time identifies FACT as a novel effector of MYCN-driven neuroblastoma tumorigenesis. Inhibitors of the FACT complex may be a novel treatment for high risk MYCN-amplified neuroblastoma and a potential strategy for neuroblastoma prevention.<\/jats:p>\n 1. Hansford, L. et al. Mechanisms of embryonal tumor initiation: Distinct roles for MycN expression and MYCN amplification. Proceedings of the National Academy of Sciences of the United States of America 101, 12664-12669 (2004).<\/jats:p>\n 2. Calao, M. et al. Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation. Oncogene [ahead of print]<\/jats:p>\n Citation Format: Daniel R. Carter, Belamy B. Cheung, Tao Liu, Carol Au, Murray D. Norris, Michelle Haber, Jayne Murray, Katerina V. Gurova, Andrei V. Gudkov, Glenn M. Marshall. The facilitates chromatin transcription (FACT) protein complex promotes neuroblastoma tumor initiation. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5043. doi:10.1158\/1538-7445.AM2013-5043<\/jats:p>","DOI":"10.1158\/1538-7445.am2013-5043","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T22:46:55Z","timestamp":1408056415000},"page":"5043-5043","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 5043: The facilitates chromatin transcription (FACT) protein complex promotes neuroblastoma tumor initiation."],"prefix":"10.1158","volume":"73","author":[{"given":"Daniel R.","family":"Carter","sequence":"first","affiliation":[{"name":"1Children's Cancer Institute Australia, Randwick, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belamy B.","family":"Cheung","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Randwick, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Randwick, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Au","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Randwick, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray D.","family":"Norris","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Randwick, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Haber","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Randwick, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayne","family":"Murray","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Randwick, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina V.","family":"Gurova","sequence":"additional","affiliation":[{"name":"2Roswell Park Cancer Institute, Buffalo, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei V.","family":"Gudkov","sequence":"additional","affiliation":[{"name":"2Roswell Park Cancer Institute, Buffalo, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn M.","family":"Marshall","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Randwick, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/73\/8_Supplement\/5043\/590933\/Abstract-5043-The-facilitates-chromatin","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/73\/8_Supplement\/5043\/590933\/Abstract-5043-The-facilitates-chromatin","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T13:03:02Z","timestamp":1656594182000},"score":7.562642,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/73\/8_Supplement\/5043\/590933\/Abstract-5043-The-facilitates-chromatin"}},"issued":{"date-parts":[[2013,4]]},"references-count":0,"journal-issue":{"issue":"8_Supplement","published-print":{"date-parts":[[2013,4,15]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2013-5043","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published-other":{"date-parts":[[2013,4]]},"published":{"date-parts":[[2013,4]]}},{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T17:40:20Z","timestamp":1775497220924,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2019,10]]},"abstract":"Aim<\/jats:title>University students have high rates of mental health problems; however, most delay or fail to seek help altogether. Tertiary settings can offer educational and social programmes to increase mental health awareness and in turn increase the number of students seeking help for their problems. This study aimed to explore students' and staffs' knowledge of mental health issues, confidence to intervene and application of skills following Mental Health First Aid (MHFA) training.<\/jats:p><\/jats:sec>Methods<\/jats:title>Students and staff at an Australian university who had completed MHFA training in the previous 24 months were invited to complete a validated online questionnaire.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 566 eligible participants, 107 (19%) completed the questionnaire. The majority (65%) had applied their skills to someone in need, with the highest number applying it to students. Notably, of those who had applied their skills 23 participants (33%) had applied them in a crisis situation, the most common being panic attacks followed by suicidal thoughts. Although most (98%) applied their skills in a face\u2010to\u2010face capacity, 53% also reported assisting someone via electronic mediums and social media. The mean score for the literacy test was considered high, 12\/16 (SD = 1.7) for students and 13\/16 (SD = 2.5) for staff. The majority (94%) reported more confidence in providing support following training.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study demonstrated that MHFA training on a university campus is associated with a high level of knowledge, confidence to intervene and apply MHFA skills to assist a student or friend in need, potentially impacting their long\u2010term health outcomes and future professional careers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12742","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T09:14:33Z","timestamp":1539162873000},"page":"1121-1128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Evaluation of Mental Health First Aid skills in an Australian university population"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2901-5460","authenticated-orcid":false,"given":"Deena","family":"Ashoorian","sequence":"first","affiliation":[{"name":"Pharmacy Division, School of Allied Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristy\u2010Lee","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Pharmacy Division, School of Allied Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey","family":"Baxter","sequence":"additional","affiliation":[{"name":"Pharmacy Division, School of Allied Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Giftakis","sequence":"additional","affiliation":[{"name":"Pharmacy Division, School of Allied Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonda","family":"Clifford","sequence":"additional","affiliation":[{"name":"Pharmacy Division, School of Allied Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayden","family":"Greenwell\u2010Barnden","sequence":"additional","affiliation":[{"name":"Health Promotion Unit University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tricia","family":"Wylde","sequence":"additional","affiliation":[{"name":"Health Promotion Unit University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Australian Bureau of Statistics. (2008).National Survey of Mental Health and Wellbeing 2007. Canberra: Australian Bureau of Statistics. Retrieved fromhttp:\/\/www.abs.gov.au\/AUSSTATS\/abs@.nsf\/Lookup\/4326.0Main+Features12007"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.10.054"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40359-015-0069-0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-017-1278-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/01612840.2015.1088322"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-015-0403-3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867411435290"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-016-2887-2"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1521\/suli.34.1.56.27773"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10673229.2012.712839"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-10-113"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2009.08.008"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S092427080003252X"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5680"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00048674.2011.594785"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-5-43"},{"issue":"470","key":"e_1_2_5_18_1","first-page":"730","article-title":"Perspectives of people with enduring mental ill health from a community\u2010based qualitative study","volume":"51","author":"Kai J.","year":"2001","journal-title":"British Journal of General Practice"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-2-10"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1614.2006.01735.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7893.2007.00056.x"},{"key":"e_1_2_5_22_1","volume-title":"Mental Health First Aid Manual","author":"Kitchener B. 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Ramzan , and K. Dahal , Remote patient monitoring: a comprehensive study. Journal of Ambient Intelligence and Humanized Computing , 201 9. 10(1): p. 57 - 76 . Malasinghe, L.P., N. Ramzan, and K. Dahal, Remote patient monitoring: a comprehensive study. Journal of Ambient Intelligence and Humanized Computing, 2019. 10(1): p. 57-76.","journal-title":"Humanized Computing"},{"key":"e_1_3_2_1_2_1","first-page":"515","volume":"201","author":"Prgomet M.","unstructured":"Prgomet , M. , , Vital signs monitoring on general wards: clinical staff perceptions of current practices and the planned introduction of continuous monitoring technology. Int J Qual Health Care , 201 6. 28(4): p. 515 - 521 . Prgomet, M., , Vital signs monitoring on general wards: clinical staff perceptions of current practices and the planned introduction of continuous monitoring technology. 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Surgical subspecialties have successfully combined robotic technology with traditional practices. In doing so, they have benefited from increased precision in techniques, reduced incidence of surgical complications, and reduced MSK disorders. This scoping review aims to examine the extent of cobotics in obstetric ultrasound. The review was conducted using the JBI PRISMA protocol to map the topic of robotics in obstetric ultrasound. Teleoperated remote ultrasound formed the largest combined clinical cohort of 67 patients. Limitations of the 20\u2010week scan concerned incomplete visualization of fetal structures. These included cavum septi pellucidi, cardiac outflow tracts, kidneys, lips and spine. Third trimester scans omitted umbilical artery Doppler measures. Patients having telerobotic ultrasound report the experience as \u201ccomfortable\u201d and would agree to repeat the robotic scan in the future. Obstetric cobotic literature was found to focus on the following subtopics: robotic\u2010assisted ultrasound, automated image acquisition, image stitching and fusion, teleoperated remote ultrasound, and ultrasound\u2010guided robotic surgery. Ultrasound\u2010guided robotic surgery was performed for maternal partial nephrectomy and cervical cerclage. The most mature application of obstetric cobotics is seen in teleoperated remote ultrasound, where pilot trials have used clinical patients. Other areas are early in the research phase, with investigation for proof of concept testing.<\/jats:p>","DOI":"10.1002\/sono.12535","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T20:59:22Z","timestamp":1751489962000},"page":"583-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cobotic Ultrasound Systems in Obstetric Assessment: A Scoping Review"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9097-7859","authenticated-orcid":false,"given":"Caterina","family":"Watson","sequence":"first","affiliation":[{"name":"Edith Cowan University Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9634-016X","authenticated-orcid":false,"given":"Leisa","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Edith Cowan University Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2264-8719","authenticated-orcid":false,"given":"David","family":"Cook","sequence":"additional","affiliation":[{"name":"Edith Cowan University Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8037-1412","authenticated-orcid":false,"given":"T. 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We aimed to examine the association between MRI-based fat depots and risk of diabetes.<\/jats:p>\n Methods: All participants without diabetes who attended the UK Biobank imaging visit were included. MRI-measured fat depots included abdominal subcutaneous adipose tissue (ASAT, in liters), visceral adipose tissue (VAT, in liters), liver proton density fat (LF, in fraction) and muscle fat infiltration (MFI, in fraction). Cox proportional hazards regression was used to estimate their associations with incident diabetes, reported as hazards ratios (HRs) and 95% confidence intervals (CIs).<\/jats:p>\n Results: Of the 41,233 participants (mean age: 66 years) included, 245 developed diabetes over a median follow-up of 3.6 years. In models adjusted for age, sex and ethnicity, increasing levels of ASAT, VAT, LF and MFI were significantly associated with elevated risk of developing diabetes. However, the HRs for ASAT decreased after additional adjustment for BMI, and became negatively associated with diabetes when adjusted for BMI and other fat depots. The HRs for MFI attenuated and lost significance after additional adjustments for BMI or other fat depots. In contrast, VAT and LF remained consistently associated with higher hazards of diabetes across all models. The age-, sex-, ethnicity- and BMI-adjusted HRs per SD increase were 2.53 (95% CI: 1.97\u25003.25) for VAT and 1.75 (95% CI: 1.55\u25001.97) for LF. These associations persisted when additionally adjusted for lifestyle and social deprivation index.<\/jats:p>\n Conclusion: Visceral adipose tissue volume demonstrated a stronger association with risk of diabetes than did other fat depots. These findings highlight the central role of VAT in the development of diabetes.<\/jats:p>\n \n Disclosure<\/jats:title>\n D. Wang: None. J.I. Morton: None. D.J. Magliano: None. J.E. Shaw: Advisory Panel; GlaxoSmithKline plc. Speaker's Bureau; AstraZeneca, Roche Diagnostics, Boehringer-Ingelheim, Zuellig Pharma. Advisory Panel; Novo Nordisk.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db25-1726-p","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:28:34Z","timestamp":1749792514000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["1726-P: Comparison of Subcutaneous, Visceral, Liver, and Muscle Fat Depots in Relation to Diabetes Risk\u2014A Prospective Cohort Study"],"prefix":"10.2337","volume":"74","author":[{"given":"DANYANG","family":"WANG","sequence":"first","affiliation":[{"name":"Melbourne, Victoria, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEDIDIAH I.","family":"MORTON","sequence":"additional","affiliation":[{"name":"Melbourne, Victoria, Australia, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DIANNA J.","family":"MAGLIANO","sequence":"additional","affiliation":[{"name":"Melbourne, 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban","family":"Roy","sequence":"additional","affiliation":[{"name":"Medtronic MiniMed, Northridge, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew N.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Dart","sequence":"additional","affiliation":[{"name":"Princess Margaret Hospital for Children, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn L.","family":"Berthold","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Retterath","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate E.","family":"Freeman","sequence":"additional","affiliation":[{"name":"Princess Margaret Hospital for Children, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benyamin","family":"Grosman","sequence":"additional","affiliation":[{"name":"Medtronic MiniMed, Northridge, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Kurtz","sequence":"additional","affiliation":[{"name":"Medtronic MiniMed, Northridge, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Medtronic MiniMed, Northridge, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Princess Margaret Hospital for Children, Perth, Western Australia, Australia"},{"name":"Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Princess Margaret Hospital for Children, Perth, Western Australia, Australia"},{"name":"Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2015,8,27]]},"reference":[{"key":"2022031301362655200_B1","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.2337\/dc13-2911","article-title":"Day and night home closed-loop insulin delivery in adults with type 1 diabetes: three-center randomized crossover study","volume":"37","author":"Leelarathna","year":"2014","journal-title":"Diabetes Care"},{"key":"2022031301362655200_B2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1056\/NEJMoa1314474","article-title":"Outpatient glycemic control with a bionic pancreas in type 1 diabetes","volume":"371","author":"Russell","year":"2014","journal-title":"N Engl J Med"},{"key":"2022031301362655200_B3","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.2337\/dc13-2644","article-title":"Overnight closed-loop insulin delivery in young people with type 1 diabetes: a free-living, randomized clinical 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Care"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/38\/11\/e186\/622402\/dc151047.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/38\/11\/e186\/622402\/dc151047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T05:30:15Z","timestamp":1647149415000},"score":7.5621643,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/38\/11\/e186\/37659\/Feasibility-of-Outpatient-24-Hour-Closed-Loop"}},"issued":{"date-parts":[[2015,8,27]]},"references-count":5,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,8,27]]},"published-print":{"date-parts":[[2015,11,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc15-1047","ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"published":{"date-parts":[[2015,8,27]]}},{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:13:45Z","timestamp":1784686425630,"version":"3.55.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2024,2,1]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n We investigated shear wave elastography (SWE), B mode US and power Doppler (PDUS) as imaging biomarkers for longitudinal follow-up in idiopathic inflammatory myopathy (IIM), with a particular focus on immune-mediated necrotizing myopathy (IMNM) and DM.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Participants had serial SWE, PDUS on the deltoid (D) and vastus lateralis (VL) muscles on four occasions at intervals of 3\u20136\u2009months. Clinical assessments included manual muscle testing, and patient- and physician-reported outcome scales.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Thirty-three participants were included: IMNM\u2009=\u200917, DM\u2009=\u200912, overlap myositis\u2009=\u20093, PM\u2009=\u20091. Twenty were in a prevalent clinic group, and 13 were recently treated cases in an incident group. Differential changes in SWS and US domains occurred with time in both the prevalent and incident groups. In the VL-prevalent subgroup, echogenicity increased over time (P\u2009=\u20090.040), while in the incident cases there was a trend for reduction to normal over time (P\u2009=\u20090.097) with treatment. Muscle bulk reduced in the D-prevalent subgroup over time (P\u2009=\u20090.096), suggesting atrophy. SWS also reduced in the VL-incident subgroup over time (P\u2009=\u20090.096), suggesting a trend towards improvement in muscle stiffness with treatment.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n SWE and US appear promising as imaging biomarkers for patient follow-up in IIM and indicate changes over time, especially with echogenicity, muscle bulk and SWS in the VL. Due to the limitations of the participant numbers, additional studies with a larger cohort are needed to help evaluate these US domains further and outline specific characteristics within the IIM subgroups.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/rheumatology\/kead239","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T01:42:24Z","timestamp":1684978944000},"page":"490-497","source":"Crossref","is-referenced-by-count":7,"title":["The longitudinal study of muscle changes with ultrasound: differential changes in idiopathic inflammatory myopathy subgroups"],"prefix":"10.1093","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6401-4530","authenticated-orcid":false,"given":"Shereen","family":"Paramalingam","sequence":"first","affiliation":[{"name":"University of Notre Dame Australia , Fremantle, Western Australia, Australia"},{"name":"Department of Rheumatology, Fiona Stanley Hospital , Murdoch, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merrilee","family":"Needham","sequence":"additional","affiliation":[{"name":"University of Notre Dame Australia , Fremantle, Western Australia, Australia"},{"name":"Institute for Immunology and Infectious Diseases, Murdoch University , Murdoch, Western Australia, Australia"},{"name":"Department of Neurology, Fiona Stanley Hospital , Murdoch, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Bulsara","sequence":"additional","affiliation":[{"name":"Institute for Health Research, Notre Dame Australia , Fremantle, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank L","family":"Mastaglia","sequence":"additional","affiliation":[{"name":"Perron Institute for Neurological and Translational Science, University of Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen I","family":"Keen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Fiona Stanley Hospital , Murdoch, Western Australia, Australia"},{"name":"School of Medicine, University of Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"2024020223064409400_kead239-B1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/imj.15358","article-title":"Idiopathic inflammatory myopathies: a review","volume":"51","author":"Ashton","year":"2021","journal-title":"Intern Med J"},{"key":"2024020223064409400_kead239-B2","doi-asserted-by":"crossref","first-page":"101765","DOI":"10.1016\/j.berh.2022.101765","article-title":"Muscle imaging in myositis: MRI, US, and PET","volume":"36","author":"Albayda","year":"2022","journal-title":"Best Pract Res Clin 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inflammatory myopathies: a pilot cross-sectional study","volume":"22","author":"Paramalingam","year":"2021","journal-title":"BMC Musculoskelet Disord"},{"key":"2024020223064409400_kead239-B17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s41927-022-00276-w","article-title":"Muscle B mode ultrasound and shear-wave elastography in idiopathic inflammatory myopathies (SWIM): criterion validation against MRI and muscle biopsy findings in an incident patient cohort","volume":"6","author":"Paramalingam","year":"2022","journal-title":"BMC Rheumatol"},{"key":"2024020223064409400_kead239-B18","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0022-3476(82)80286-2","article-title":"Ultrasound imaging in the diagnosis of muscle disease","volume":"101","author":"Heckmatt","year":"1982","journal-title":"J Pediatr"},{"key":"2024020223064409400_kead239-B19","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1002\/art.40240","article-title":"Muscle ultrasonography is a potential tool for detecting fasciitis in dermatomyositis and polymyositis: comment on the article by Yoshida et al","volume":"69","author":"Bhansing","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"2024020223064409400_kead239-B20","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/mus.24595","article-title":"Increased fascial thickness of the deltoid muscle in dermatomyositis and polymyositis: an ultrasound study","volume":"52","author":"Bhansing","year":"2015","journal-title":"Muscle Nerve"},{"key":"2024020223064409400_kead239-B21","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s41927-022-00302-x","article-title":"Correction to: Muscle B mode ultrasound and shear-wave elastography in idiopathic inflammatory myopathies (SWIM): criterion validation against MRI and muscle biopsy findings in an incident patient cohort","volume":"6","author":"Paramalingam","year":"2022","journal-title":"BMC 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Society of Clinical Oncology (ASCO)","issue":"15_suppl","funder":[{"name":"None"}],"content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2021,5,20]]},"abstract":" e24028 <\/jats:p> Background: Given the impact of COVID-19 on Indigenous and ethnic minority populations observed globally, keeping COVID-19 out of vulnerable Aboriginal and Torres Strait Islander (Indigenous Australian) communities remains a priority. Compared to non-Indigenous Australians, Indigenous Australians experience disparities in cancer incidence and outcomes due to social disadvantage, increased cancer-related modifiable risk factors, poorer access to health services and lower participation in screening. During the pandemic, cancer-related investigations and treatment reduced significantly in Australia, leading to potential decreases in cancer diagnoses and consequences for future survival outcomes. Concerned about the risk of morbidity and mortality due to COVID-19 for Indigenous Australians, as well as worsening cancer outcomes, Cancer Australia undertook strategic health promotion initiatives, to inform and support optimal cancer care. Methods: In consultation with respected Indigenous colleagues to ensure cultural appropriateness of language and information, we published a dedicated webpage titled \u2018 Cancer and COVID-19 \u2013 what it means for our Mob*\u2019 with tailored information, advice, and links to key resources and support services for Indigenous Australians. We also released a video titled \u2018 Act early for our Mob\u2019s Health\u2019, providing targeted, culturally appropriate, consumer-friendly information to encourage Indigenous Australians to see their doctor or Aboriginal Health Worker with symptoms that may be due to cancer. Results: The information hub has been well-received among the Indigenous Australian community, receiving over 3,200 visits, and the social media campaigns have received over 1.4 million impressions and 46,000 video views between mid-March 2020 to mid-February 2021. This campaign has supported proactivity among the Indigenous population in keeping their communities safe during the pandemic, maintaining a population rate of COVID-19 of less than one percent of all confirmed cases in Australia. Conclusions: Culturally appropriate information and resources developed through the process of co-design can help to influence positive health behaviour change in Indigenous populations. We predict that our strategic, multi-channel health promotion campaign is contributing to keeping the Indigenous Australian community safe and informed during the pandemic, with additional work needed to monitor cancer rates and outcomes and address the ongoing information needs of the community. *Mob is a colloquial term to identify a group of Indigenous Australians associated with a family or community from a certain place. <\/jats:p>","DOI":"10.1200\/jco.2021.39.15_suppl.e24028","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T15:09:25Z","timestamp":1622646565000},"page":"e24028-e24028","update-policy":"http:\/\/dx.doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["COVID-19 and cancer: Strategic health promotion for indigenous Australians during a pandemic."],"prefix":"10.1200","volume":"39","author":[{"given":"Carolyn","family":"Der Vartanian","sequence":"first","affiliation":[{"name":"Cancer Australia, Surry 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Oncology"],"language":"en","deposited":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T15:15:22Z","timestamp":1622646922000},"score":7.5620728,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2021.39.15_suppl.e24028"}},"issued":{"date-parts":[[2021,5,20]]},"references-count":0,"journal-issue":{"issue":"15_suppl","published-print":{"date-parts":[[2021,5,20]]}},"alternative-id":["10.1200\/JCO.2021.39.15_suppl.e24028"],"URL":"https:\/\/doi.org\/10.1200\/jco.2021.39.15_suppl.e24028","ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"published":{"date-parts":[[2021,5,20]]},"assertion":[{"value":"2021-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:49:59Z","timestamp":1786135799028,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid 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Australia;"},{"name":"Australian Centre for Accelerating Diabetes Innovations, Melbourne, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott David","family":"Bringans","sequence":"additional","affiliation":[{"name":"Proteomics International, Perth, Western Australia, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Kwok Ching","family":"Lui","sequence":"additional","affiliation":[{"name":"Proteomics International, Perth, Western Australia, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasha S. C.","family":"Lumbantobing","sequence":"additional","affiliation":[{"name":"Proteomics International, Perth, Western Australia, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Davis","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Western Australia, Australia;"},{"name":"Australian Centre for Accelerating Diabetes Innovations, Melbourne, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lipscombe","sequence":"additional","affiliation":[{"name":"Proteomics International, Perth, Western Australia, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Journal of the American Society of Nephrology"],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.20245pn169b7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:49:57Z","timestamp":1786132197000},"score":7.56206,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.20245pn169b7"}},"subtitle":["SA-PO320"],"issued":{"date-parts":[[2024,10]]},"references-count":0,"journal-issue":{"issue":"10S","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.20245pn169b7","ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"published":{"date-parts":[[2024,10]]}},{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:37:31Z","timestamp":1764333451213,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>This study aimed to explore the dental staff knowledge of simulated patient methodology and support for its use to investigate dental staffs' triaging ability.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>Staff at dental practices in Western Australia were invited to participate in a cross\u2010sectional online questionnaire, consisting of demographic questions, questions on triaging, and knowledge of simulated patient methodology. Descriptive and parametric tests were undertaken for quantitative data; qualitative responses were thematically analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 100 participants, most were female (71%), aged 25\u221239 years (57%), dentists (46%), and worked in private practices (60%). While 82% of participants triaged dental appointment enquiries, only 26% had heard of simulated patient studies. The majority (66%) of participants spent 1\u22125\u2009min when triaging appointments and less than half (29%) asked about medical history, aggravating or alleviating factors. Although there was a general positive attitude toward\u00a0use of simulated patient methodology to investigate practice, some concerns were identified.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The findings of our exploratory study suggests that there may be a potential for utilizing simulated patient studies to improve the care of patients by dental receptionists in general dental practices.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.906","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T05:24:56Z","timestamp":1720243496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the usability of simulated patient methodology in dental clinics in Western Australia:\u00a0A pilot survey"],"prefix":"10.1002","volume":"10","author":[{"given":"Viduni","family":"Liyange","sequence":"first","affiliation":[{"name":"UWA Dental School The University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin Rong","family":"Low","sequence":"additional","affiliation":[{"name":"UWA Dental School The University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2052-558X","authenticated-orcid":false,"given":"Joon Soo","family":"Park","sequence":"additional","affiliation":[{"name":"UWA Dental School The University of Western Australia Nedlands Western Australia Australia"},{"name":"International Research Collaborative\u2014Oral Health and Equity The University of Western Australia Crawley Western Australia Australia"},{"name":"School of Allied Health The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6067-8751","authenticated-orcid":false,"given":"Hien C.","family":"Ngo","sequence":"additional","affiliation":[{"name":"UWA Dental School The University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonda","family":"Clifford","sequence":"additional","affiliation":[{"name":"School of Allied Health The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liza","family":"Seubert","sequence":"additional","affiliation":[{"name":"School of Allied Health The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2007.tb00522.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijpp\/riaa002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2021.04.007"},{"key":"e_1_2_11_5_1","unstructured":"Australian Commission on Safety and Quality in Health Care. (2015).NSQHS standards guide for dental practices and services [Internet].https:\/\/www.safetyandquality.gov.au\/publications-and-resources\/resource-library\/nsqhs-standards-guide-dental-practices-and-services"},{"key":"e_1_2_11_6_1","unstructured":"Australian Dental Association. (2023).Dental Assistant [Internet].https:\/\/www.ada.org.au\/Careers\/Dental-Team\/Assistant"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpp.12570"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-020-2177-3"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2007.04448.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2019.97"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-020-1199-1"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41404-020-0472-y"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6920-11-69"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijpp\/riae019"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-0009.2012.00680.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M086"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1P142"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4321\/S1886-36552013000300001"},{"key":"e_1_2_11_19_1","unstructured":"Scottish Dental Clinical Effectiveness Programme. (2007).Emergency dental care: dental clinical guidance [Internet].https:\/\/www.sdcep.org.uk\/wp-content\/uploads\/2013\/03\/EDC+Guidance.pdf"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu078"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7174.2012.00201.x"}],"container-title":["Clinical and Experimental Dental Research"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T09:27:53Z","timestamp":1725010073000},"score":7.5619154,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.906"}},"issued":{"date-parts":[[2024,7,5]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/cre2.906"],"URL":"https:\/\/doi.org\/10.1002\/cre2.906","archive":["Portico"],"ISSN":["2057-4347","2057-4347"],"issn-type":[{"type":"print","value":"2057-4347"},{"type":"electronic","value":"2057-4347"}],"published":{"date-parts":[[2024,7,5]]},"assertion":[{"value":"2023-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e906"},{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:44:09Z","timestamp":1785509049436,"version":"3.56.0"},"reference-count":42,"publisher":"American Diabetes Association","issue":"7","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":2999,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2013,7,1]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Best-practice diabetes care can reduce the burden of diabetes and associated health care costs. But this requires access to a multidisciplinary team with the right skill mix. We applied a needs-driven evidence-based health workforce model to describe the primary care team required to support best-practice diabetes care, paying particular attention to diverse clinic populations.<\/jats:p>\n <\/jats:sec>\n \n RESEARCH DESIGN AND METHODS<\/jats:title>\n Care protocols, by number and duration of consultations, were derived for twenty distinct competencies based on clinical practice guidelines and structured input from a multidisciplinary clinical panel. This was combined with a previously estimated population profile of persons across 26 patient attributes (i.e., type of diabetes, complications, and threats to self-care) to estimate clinician contact hours by competency required to deliver best-practice care in the study region.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n A primary care team of 22.1 full-time-equivalent (FTE) positions was needed to deliver best-practice primary care to a catchment of 1,000 persons with diabetes with the attributes of the Australian population. Competencies requiring greatest contact time were psychosocial issues and dietary advice at 3.5 and 3.3 FTE, respectively (1 FTE\/\u223c300 persons); home (district) nursing at 3.2 FTE; and diabetes education at 2.8 FTE. The annual cost of delivering care was estimated at just over 2,000 Australian dollars (\u223c2,090 USD) (2012) per person with diabetes.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n A needs-driven approach to primary care service planning identified a wider range of competencies in the diabetes primary and community care team than typically described. Access to psychosocial competences as well as medical management is required if clinical targets are to be met, especially in disadvantaged groups.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/dc12-1793","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T09:23:58Z","timestamp":1360315438000},"page":"1898-1907","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":31,"title":["Regional Primary Care Team to Deliver Best-Practice Diabetes Care"],"prefix":"10.2337","volume":"36","author":[{"given":"Leonie","family":"Segal","sequence":"first","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Leach","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"May","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Turnbull","sequence":"additional","affiliation":[{"name":"Department of Health and Ageing, Adelaide, South Australia, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2013,6,12]]},"reference":[{"key":"2022031222411054300_B1"},{"key":"2022031222411054300_B2","article-title":"Global Prevalence of Diabetes: Estimates for the Year 2000 and Projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"2022031222411054300_B3"},{"key":"2022031222411054300_B4"},{"key":"2022031222411054300_B5","unstructured":"Segal L, Robertson I. Diabetes Integrated Care Trial Mid-North Coast New South Wales: Economic Evaluation, Research Report 21. Melbourne, Australia, Centre for Health Economics, Monash University, 2001"},{"key":"2022031222411054300_B6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1472-6963-6-84","article-title":"Comorbidity in patients with diabetes mellitus: impact on medical health care utilization","volume":"6","author":"Struijs","year":"2006","journal-title":"BMC Health Serv Res"},{"key":"2022031222411054300_B7","unstructured":"Page A, Ambrose S, Glover J, Hetzel D. Atlas of avoidable hospitalisations in Australia: ambulatory care-sensitive conditions. Canberra, Australia, Australian Institute of Health & Welfare, 2007 (cat. no. HSE 49)"},{"key":"2022031222411054300_B8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0735-1097(01)01761-2","article-title":"A randomized trial of the efficacy of multidisciplinary care in heart failure outpatients at high risk of hospital readmission","volume":"39","author":"Kasper","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2022031222411054300_B9","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.2337\/dc10-0843","article-title":"Cost-effectiveness of interventions to prevent and control diabetes mellitus: a systematic review","volume":"33","author":"Li","year":"2010","journal-title":"Diabetes Care"},{"key":"2022031222411054300_B10","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/eurheartj\/ehi251","article-title":"Adherence to guidelines is a predictor of outcome in chronic heart failure: the MAHLER survey","volume":"26","author":"Komajda","year":"2005","journal-title":"Eur Heart J"},{"key":"2022031222411054300_B11","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1464-5491.2010.02981.x","article-title":"Are clinical practical guidelines (CPGs) useful for health services and health workforce planning? A critique of diabetes CPGs","volume":"27","author":"Leach","year":"2010","journal-title":"Diabet Med"},{"key":"2022031222411054300_B12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/1472-6963-11-221","article-title":"Patient attributes warranting consideration in clinical practice guidelines, health workforce planning and policy","volume":"11","author":"Leach","year":"2011","journal-title":"BMC Health Serv Res"},{"key":"2022031222411054300_B13","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1464-5491.2006.01878.x","article-title":"Alcohol consumption is inversely associated with adherence to diabetes self-care behaviours","volume":"23","author":"Ahmed","year":"2006","journal-title":"Diabet Med"},{"key":"2022031222411054300_B14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1023\/B:JOHE.0000016719.89848.b1","article-title":"Characteristics of low-income African-American and Caucasian adults that are important in self-management of type 2 diabetes","volume":"29","author":"Cox","year":"2004","journal-title":"J Community Health"},{"key":"2022031222411054300_B15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1445-5994.2006.01247.x","article-title":"Characteristics and outcome of type 2 diabetes in urban Aboriginal people: the Fremantle Diabetes Study","volume":"37","author":"Davis","year":"2007","journal-title":"Intern Med J"},{"key":"2022031222411054300_B16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1477-7525-5-10","article-title":"Self-report and parent-report of physical and psychosocial well-being in Dutch adolescents with type 1 diabetes in relation to glycemic control","volume":"5","author":"de Wit","year":"2007","journal-title":"Health Qual Life Outcomes"},{"key":"2022031222411054300_B17","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1176\/appi.psy.47.3.240","article-title":"Prospective study on influence of psychosocial factors on glycemic control in Japanese patients with type 2 diabetes","volume":"47","author":"Nakahara","year":"2006","journal-title":"Psychosomatics"},{"key":"2022031222411054300_B18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1108\/13660750310486730","article-title":"The social determinants of the incidence and management of type 2 diabetes mellitus: are we prepared to rethink our questions and redirect our research activities?","volume":"16","author":"Raphael","year":"2003","journal-title":"Leadersh Health Serv"},{"key":"2022031222411054300_B19","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.amjmed.2006.02.010","article-title":"Do patients with diabetes and low socioeconomic status receive less care and have worse outcomes? A national study","volume":"119","author":"Jotkowitz","year":"2006","journal-title":"Am J Med"},{"key":"2022031222411054300_B20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/0272989X05284107","article-title":"An alternative approach to reducing the costs of patient care? A controlled trial of the multi-disciplinary doctor-nurse practitioner (MDNP) model","volume":"26","author":"Ettner","year":"2006","journal-title":"Med Decis Making"},{"key":"2022031222411054300_B21","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1681\/ASN.2006080860","article-title":"Association between multidisciplinary care and survival for elderly patients with chronic kidney disease","volume":"18","author":"Hemmelgarn","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"2022031222411054300_B22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1748-5908-3-35","article-title":"A work force model to support the adoption of best practice care in chronic diseases - a missing piece in clinical guideline implementation","volume":"3","author":"Segal","year":"2008","journal-title":"Implement Sci"},{"key":"2022031222411054300_B23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1748-5908-6-93","article-title":"An evidence-based health workforce model for primary and community care","volume":"6","author":"Segal","year":"2011","journal-title":"Implement Sci"},{"key":"2022031222411054300_B24"},{"key":"2022031222411054300_B25","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.2337\/dc11-S011","article-title":"Standards of medical care in diabetes\u20142011","volume":"34","author":"American Diabetes Association","year":"2011","journal-title":"Diabetes Care"},{"key":"2022031222411054300_B26","first-page":"S1","article-title":"Canadian Diabetes Association 2008 clinical practice guidelines for the prevention and management of diabetes in Canada","volume":"32","author":"Canadian Diabetes Association","year":"2008","journal-title":"Can J Diabetes"},{"key":"2022031222411054300_B27"},{"key":"2022031222411054300_B28","unstructured":"Health Economics and Social Policy Group. [Article online], 2012. Adelaide, Australia, University of South Australia. Available from http:\/\/www.unisa.edu.au\/research\/sansom-institute-for-health-research\/research-at-the-sansom\/research-concentrations\/health-economics-and-social-policy-\/"},{"key":"2022031222411054300_B29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1046\/j.1464-5491.2003.00881.x","article-title":"Foot complications in Type 2 diabetes: an Australian population-based study","volume":"20","author":"Tapp","year":"2003","journal-title":"Diabet Med"},{"key":"2022031222411054300_B30","unstructured":"Department of Health and Ageing. Public sector - estimated round 14 (2009-10) AR-DRG5.2 cost report [article online], 2012. Canberra, Australia, Australian Government. Available from http:\/\/www.health.gov.au\/internet\/main\/publishing.nsf\/content\/adf42b9ac16d4017ca257864000fbd0e\/$file\/r14cwnatest_v52.pdf. 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Evidence from the medicine in Australia: balancing employment and life survey","volume":"21","author":"Cheng","year":"2012","journal-title":"Health Econ"}],"container-title":["Diabetes Care"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/36\/7\/1898\/618563\/1898.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/36\/7\/1898\/618563\/1898.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:57:19Z","timestamp":1647133039000},"score":7.5618677,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/36\/7\/1898\/33149\/Regional-Primary-Care-Team-to-Deliver-Best"}},"issued":{"date-parts":[[2013,6,12]]},"references-count":42,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,6,12]]},"published-print":{"date-parts":[[2013,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc12-1793","ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"published":{"date-parts":[[2013,6,12]]}},{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:23:54Z","timestamp":1781623434466,"version":"3.54.5"},"reference-count":11,"publisher":"CSIRO Publishing","issue":"2","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":750,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2023,5,11]]},"abstract":"Low-emission hydrogen is emerging as an integral building block for the decarbonisation of the global economy, serving as a complementary emission reduction solution to direct electrification and the use of other low emission technologies such as bioenergy. Presently, hydrogen is a key global commodity used within the production of chemicals including ammonia and for refining activities. These existing uses offer an initial demand market for low-emission hydrogen as a replacement for the high-emitting alternative. Furthermore, new applications for low-emission hydrogen are emerging within hard-to-abate industries where other decarbonisation solutions are less technically or commercially viable or have constrained feedstocks. These applications include as an input for steel production and as a fuel for the transport industry, particularly for heavy-duty long-haul road transport as well as the use of hydrogen-derivatives within the maritime and aviation industries. However, for a low-emission hydrogen industry to develop, the disconnect between consumer and producer expectations, high production and end-use technology costs and regulatory challenges must be overcome. Important mechanisms to achieve this include the implementation of targets and mandates for low-emission hydrogen production and uptake, facilitation of product premiums by industry, targeted public funding and financing and revenue support mechanisms.<\/jats:p>","DOI":"10.1071\/aj22195","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T20:13:39Z","timestamp":1683749619000},"page":"S464-S467","source":"Crossref","is-referenced-by-count":1,"title":["Opportunity of the future: hydrogen as fuel and feedstock"],"prefix":"10.1071","volume":"63","author":[{"given":"Matthew","family":"Walden","sequence":"first","affiliation":[{"name":"ADeloitte Australia, Sydney, NSW, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senjit","family":"Sarkar","sequence":"additional","affiliation":[{"name":"ADeloitte Australia, Sydney, NSW, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Mugford","sequence":"additional","affiliation":[{"name":"ADeloitte Australia, Sydney, NSW, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wood","sequence":"additional","affiliation":[{"name":"ADeloitte Australia, Sydney, NSW, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"2025122722312579700_R1"},{"key":"2025122722312579700_R2"},{"key":"2025122722312579700_R3"},{"key":"2025122722312579700_R4"},{"key":"2025122722312579700_R5"},{"key":"2025122722312579700_R6"},{"key":"2025122722312579700_R7"},{"key":"2025122722312579700_R8","doi-asserted-by":"publisher","DOI":"10.3390\/met10070922","article-title":"Hydrogen ironmaking: how it works.","volume":"10","author":"Patisson","year":"2020","journal-title":"Metals"},{"key":"2025122722312579700_R9"},{"key":"2025122722312579700_R10"},{"key":"2025122722312579700_R11","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.jclepro.2017.03.162","article-title":"Modeling and simulation of hydrogen injection into a blast furnace to reduce carbon dioxide emissions.","volume":"154","author":"Yilmaz","year":"2017","journal-title":"Journal of Cleaner Production"}],"container-title":["The APPEA Journal"],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/63\/2\/S464\/473729\/aj22195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/63\/2\/S464\/473729\/aj22195.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T03:31:35Z","timestamp":1766892695000},"score":7.5618014,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/ep\/article\/63\/2\/S464\/77575\/Opportunity-of-the-future-hydrogen-as-fuel-and"}},"issued":{"date-parts":[[2023,5,11]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,5,11]]}},"URL":"https:\/\/doi.org\/10.1071\/aj22195","ISSN":["1326-4966","2206-8996"],"issn-type":[{"value":"1326-4966","type":"print"},{"value":"2206-8996","type":"electronic"}],"published":{"date-parts":[[2023,5,11]]}},{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:37:00Z","timestamp":1784234220448,"version":"3.55.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2022,2,9]]},"abstract":"Abstract<\/jats:title>Globally, 27 aphid species have evolved resistance to almost 100 insecticide active ingredients. A proactive approach to resistance management in pest aphids is needed; this should include risk analysis, followed by regular baseline susceptibility assays for species deemed at high risk of evolving resistance. The cowpea aphid (Aphis craccivora Koch) has evolved insecticide resistance to multiple insecticides outside Australia and was recently identified as a high-risk species in Australia. In this study, we generated toxicity data against four insecticides (representing four unique chemical Mode of Action groups) for populations of A. craccivora collected across Australia. Alpha-cypermethrin was the most toxic chemical to A. craccivora in leaf-dip laboratory bioassays with an average LC50 value across nine populations of 0.008 mg a.i.\/L, which was significantly lower than dimethoate (1.17 mg a.i.\/L) and pirimicarb (0.89 mg a.i.\/L). Small, but significant, differences in sensitivity were detected in some populations against pirimicarb and dimethoate, whereas responses to alpha-cypermethrin and imidacloprid were not significantly different across all aphid populations examined in this study. For all insecticides, the field rate controlled 100% of individuals tested. The data generated will be important for future monitoring of insecticide responses of A. craccivora. Proactive management, including increased reliance on non-chemical pest management approaches and routine insecticide baseline sensitivity studies, is recommended for A. craccivora.<\/jats:p>","DOI":"10.1093\/jee\/toab210","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T11:11:30Z","timestamp":1635246690000},"page":"143-150","source":"Crossref","is-referenced-by-count":5,"title":["Susceptibility of the Cowpea Aphid (Hemiptera: Aphididae) to Widely Used Insecticides in Australia"],"prefix":"10.1093","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1835-3571","authenticated-orcid":false,"given":"P A","family":"Umina","sequence":"first","affiliation":[{"name":"Cesar Australia, Brunswick, Victoria, Australia"},{"name":"School of BioSciences, The University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Reidy-Crofts","sequence":"additional","affiliation":[{"name":"CSIRO, Land and Water, Floreat, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Edwards","sequence":"additional","affiliation":[{"name":"CSIRO, Land and Water, Floreat, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Chirgwin","sequence":"additional","affiliation":[{"name":"Cesar Australia, Brunswick, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ward","sequence":"additional","affiliation":[{"name":"Cesar Australia, Brunswick, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Maino","sequence":"additional","affiliation":[{"name":"Cesar Australia, Brunswick, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Babineau","sequence":"additional","affiliation":[{"name":"Cesar Australia, Brunswick, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"2022020917585860400_CIT0001","volume-title":"Australian Crop Report: June 2021 edition","author":"ABARES","year":"2021"},{"key":"2022020917585860400_CIT0002","author":"APVMA","year":"2021"},{"key":"2022020917585860400_CIT0003","doi-asserted-by":"crossref","DOI":"10.1071\/9780643095328","volume-title":"Pest of field crops and pastures: identification and control","author":"Bailey","year":"2007"},{"key":"2022020917585860400_CIT0004","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ibmb.2014.05.003","article-title":"The evolution of insecticide resistance in the peach potato aphid, Myzus persicae","volume":"51","author":"Bass","year":"2014","journal-title":"Insect Biochem. 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Physiol"}],"container-title":["Journal of Economic Entomology"],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jee\/article-pdf\/115\/1\/143\/42447157\/toab210.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jee\/article-pdf\/115\/1\/143\/42447157\/toab210.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T19:22:50Z","timestamp":1699730570000},"score":7.5617266,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jee\/article\/115\/1\/143\/6431906"}},"editor":[{"given":"Raul Narciso C","family":"Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"issued":{"date-parts":[[2021,11,19]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,11,19]]},"published-print":{"date-parts":[[2022,2,9]]}},"URL":"https:\/\/doi.org\/10.1093\/jee\/toab210","ISSN":["0022-0493","1938-291X"],"issn-type":[{"value":"0022-0493","type":"print"},{"value":"1938-291X","type":"electronic"}],"published-other":{"date-parts":[[2022,2,1]]},"published":{"date-parts":[[2021,11,19]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:08:12Z","timestamp":1753880892741,"version":"3.41.2"},"reference-count":0,"publisher":"American Society of Mechanical Engineers","content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2018,6,17]]},"abstract":"At OMAE in 2008 the \u2018state of the art\u2019 in pipeline on-bottom stability engineering was summarized, providing an overview of the current available knowledge for addressing pipeline stability. The aim of that work was to summarise key aspects of the pipeline stability design process and to include some historical perspective. The paper discusses the advantage and shortfalls of the different design approaches with a view to consolidate understanding, rather than to provide a ready-made solution to a complex design problem [1].<\/jats:p>\n Since that time, a decade of research and further methodology refinement has extended the boundaries of the industry\u2019s knowledge and understanding of the behaviour of subsea pipelines and cables, including geotechnics, hydrodynamics, oceanography and structural response modelling. In particular, progress has been made in:<\/jats:p>\n \u2022 The response of pipelines to sediment transport and scour;<\/jats:p>\n \u2022 Understanding the behaviour of small diameter pipelines and cables within wave and current boundary layers; and<\/jats:p>\n \u2022 The behaviour of cables on rocky seabeds in high energy marine environments.<\/jats:p>\n This paper summarises these innovations to enable the application of new paradigms in engineering practice and improved outcomes for initial project capital cost, reliability and operational integrity, as well as better models to predict the long-term behaviour where pipes are decommissioned in-situ.<\/jats:p>\n While a relatively widely studied field of engineering, there remain areas of active ongoing research to improve our understanding and ability to model and predict subsea pipeline on-bottom behavior, with a summary of the anticipated future opportunities proposed.<\/jats:p>","DOI":"10.1115\/omae2018-77736","type":"proceedings-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T12:31:30Z","timestamp":1537878690000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":2,"title":["Pipeline and Cable Stability: Updated State of the Art"],"prefix":"10.1115","author":[{"given":"Terry","family":"Griffiths","sequence":"first","affiliation":[{"name":"University of Western Australia, Crawley, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Draper","sequence":"additional","affiliation":[{"name":"University of Western Australia, Crawley, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"White","sequence":"additional","affiliation":[{"name":"University of Southampton, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"University of Western Australia, Crawley, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"An","sequence":"additional","affiliation":[{"name":"University of Western Australia, Crawley, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Tong","sequence":"additional","affiliation":[{"name":"University of Western Australia, Crawley, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Fogliani","sequence":"additional","affiliation":[{"name":"University of Western Australia, Crawley, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33","published-online":{"date-parts":[[2018,9,25]]},"event":{"name":"ASME 2018 37th International Conference on Ocean, Offshore and Arctic Engineering","start":{"date-parts":[[2018,6,17]]},"sponsor":["Ocean, Offshore and Arctic Engineering Division"],"location":"Madrid, Spain","end":{"date-parts":[[2018,6,22]]},"acronym":"OMAE2018"},"container-title":["Volume 5: Pipelines, Risers, and Subsea Systems"],"link":[{"URL":"http:\/\/asmedigitalcollection.asme.org\/OMAE\/proceedings-pdf\/doi\/10.1115\/OMAE2018-77736\/2536099\/v005t04a059-omae2018-77736.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T11:12:31Z","timestamp":1567422751000},"score":7.561286,"resource":{"primary":{"URL":"https:\/\/asmedigitalcollection.asme.org\/OMAE\/proceedings\/OMAE2018\/51241\/Madrid,%20Spain\/287407"}},"issued":{"date-parts":[[2018,6,17]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1115\/omae2018-77736","published":{"date-parts":[[2018,6,17]]},"article-number":"V005T04A059"},{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:33:05Z","timestamp":1785285185084,"version":"3.55.0"},"reference-count":57,"publisher":"Association for Computing Machinery (ACM)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proc. VLDB Endow."],"published-print":{"date-parts":[[2019,2]]},"abstract":"Entity resolution (ER) is the problem of accurately identifying multiple, differing, and possibly contradicting representations of unique real-world entities in data. It is a challenging and fundamental task in data cleansing and data integration. In this work, we propose graph differential dependencies (GDDs) as an extension of the recently developed graph entity dependencies (which are formal constraints for graph data) to enable approximate matching of values. Furthermore, we investigate a special discovery of GDDs for ER by designing an algorithm for generating a non-redundant set of GDDs in labelled data. Then, we develop an effective ER technique, Certus, that employs the learned GDDs for improving the accuracy of ER results. We perform extensive empirical evaluation of our proposals on five real-world ER benchmark datasets and a proprietary database to test their effectiveness and efficiency. The results from the experiments show the discovery algorithm and Certus are efficient; and more importantly, GDDs significantly improve the precision of ER without considerable trade-off of recall.<\/jats:p>","DOI":"10.14778\/3311880.3311883","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T20:22:15Z","timestamp":1553631735000},"page":"653-666","source":"Crossref","is-referenced-by-count":32,"title":["Certus<\/i>"],"prefix":"10.14778","volume":"12","author":[{"given":"Selasi","family":"Kwashie","sequence":"first","affiliation":[{"name":"University of South Australia, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixue","family":"Liu","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Stumptner","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuyong","family":"Li","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujing","family":"Yang","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"320","published-online":{"date-parts":[[2019,2]]},"reference":[{"key":"e_1_2_1_1_1","unstructured":"Cora dataset. http:\/\/www.cs.umass.edu\/~mccallum\/data\/cora-refs.tar.gz. Last accessed in June 2018. Cora dataset. http:\/\/www.cs.umass.edu\/~mccallum\/data\/cora-refs.tar.gz. Last accessed in June 2018."},{"key":"e_1_2_1_2_1","unstructured":"Dblp-acm & dblp-scholar datasets. https:\/\/dbs.uni-leipzig.de\/de\/research\/projects\/object_matching\/fever\/benchmark_datasets_for_entity_resolution. Last accessed in June 2018. Dblp-acm & dblp-scholar datasets. https:\/\/dbs.uni-leipzig.de\/de\/research\/projects\/object_matching\/fever\/benchmark_datasets_for_entity_resolution. Last accessed in June 2018."},{"key":"e_1_2_1_3_1","unstructured":"Restaurant dataset. http:\/\/www.cs.utexas.edu\/users\/ml\/riddle\/data. Last accessed in June 2018. Restaurant dataset. http:\/\/www.cs.utexas.edu\/users\/ml\/riddle\/data. Last accessed in June 2018."},{"key":"e_1_2_1_4_1","volume-title":"Addison-Wesley","author":"Abiteboul S.","year":"1995"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.5555\/645920.672836"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.14778\/2732967.2732975"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.5555\/1182635.1164206"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1145\/320610.320620"},{"key":"e_1_2_1_9_1","first-page":"73","volume-title":"Proceedings","author":"Beeri C.","year":"1981"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1145\/2723372.2742784"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1109\/TKDE.2015.2472010"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1145\/1559845.1559869"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.14778\/1920841.1920945"},{"key":"e_1_2_1_14_1","first-page":"827","volume-title":"EMNLP 2013, 18--21 October 2013, 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Part I","author":"Yu Y.","year":"2011"}],"container-title":["Proceedings of the VLDB Endowment"],"language":"en","link":[{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.14778\/3311880.3311883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T09:18:05Z","timestamp":1672219085000},"score":7.561227,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.14778\/3311880.3311883"}},"subtitle":["an effective entity resolution approach with graph differential dependencies (GDDs)"],"issued":{"date-parts":[[2019,2]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.14778\/3311880.3311883"],"URL":"https:\/\/doi.org\/10.14778\/3311880.3311883","ISSN":["2150-8097"],"issn-type":[{"value":"2150-8097","type":"print"}],"published":{"date-parts":[[2019,2]]}},{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:11:25Z","timestamp":1787317885772,"version":"build-2736575974"},"reference-count":0,"publisher":"American Society of Mechanical Engineers","license":[{"start":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T00:00:00Z","timestamp":1654387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.asme.org\/publications-submissions\/publishing-information\/legal-policies"}],"content-domain":{"domain":["asmedigitalcollection.asme.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2022,6,5]]},"abstract":"Abstract<\/jats:title>\n In recent years, floating wind has been attracting increasing attention due to its ability to be deployed in greater water depths, which are usually associated with higher wind energy. At present, floating wind technology is more expensive than fixed offshore wind, with higher cost being driven by challenges such as the extended length of mooring lines, installation of anchors in deep water etc. For floating wind to become more competitive it will be necessary to devise methods that are able to bring down the overall cost by addressing areas such as these.<\/jats:p>\n This paper presents a relatively novel concept that may help reduce the capital cost by using an arrangement of \u2018shared mooring lines\u2019. This arrangement is able to significantly reduce the number of anchors used in a windfarm, compared to the current common industry practice of using 3 mooring lines to moor each individual turbine, by connecting some of the turbines to their neighbours, rather than the seabed. Furthermore, this study aims to address a scenario in which shared mooring lines are expected to be more favourable, i.e. deep water (1000 m) and large (10 MW) turbines.<\/jats:p>\n This numerical study provides some insights to a cost-saving mooring concept for a FOWT wind farm, by investigating loads in mooring lines and anchors, as well as relative displacement of the FOWTs in the windfarm. The cost saving is roughly estimated in terms of number of anchors and length of mooring line saved \u2014 serving as preliminary guidance for shared mooring line arrangements to be applied on larger windfarms or other geometric layouts (e.g. staggered rectangular array or hexagonally shared mooring connection).<\/jats:p>","DOI":"10.1115\/omae2022-81245","type":"proceedings-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T12:32:39Z","timestamp":1666787559000},"update-policy":"https:\/\/doi.org\/10.1115\/crossmarkpolicy-asme","source":"Crossref","is-referenced-by-count":8,"title":["Preliminary Investigation of a Shared Mooring Arrangement for a Floating Offshore Wind Turbine Farm in Deep Water"],"prefix":"10.1115","author":[{"given":"Yutao","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Wolgamot","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Watson","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Gaudin","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Zhao","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Milne","sequence":"additional","affiliation":[{"name":"University of Western Australia , Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"33","published-online":{"date-parts":[[2022,10,13]]},"event":{"name":"ASME 2022 41st International Conference on Ocean, Offshore and Arctic Engineering","location":"Hamburg, Germany","acronym":"OMAE2022","sponsor":["Ocean, Offshore and Arctic Engineering Division"],"start":{"date-parts":[[2022,6,5]]},"end":{"date-parts":[[2022,6,10]]}},"container-title":["Volume 8: Ocean Renewable Energy"],"link":[{"URL":"https:\/\/asmedigitalcollection.asme.org\/OMAE\/proceedings-pdf\/doi\/10.1115\/OMAE2022-81245\/6929733\/v008t09a061-omae2022-81245.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/asmedigitalcollection.asme.org\/OMAE\/proceedings-pdf\/doi\/10.1115\/OMAE2022-81245\/6929733\/v008t09a061-omae2022-81245.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T12:32:40Z","timestamp":1666787560000},"score":7.561227,"resource":{"primary":{"URL":"https:\/\/asmedigitalcollection.asme.org\/OMAE\/proceedings\/OMAE2022\/85932\/V008T09A061\/1148071"}},"issued":{"date-parts":[[2022,6,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1115\/omae2022-81245","published":{"date-parts":[[2022,6,5]]},"article-number":"V008T09A061"},{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:04:13Z","timestamp":1767650653508,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T00:00:00Z","timestamp":1567900800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT00910000"],"award-info":[{"award-number":["GNT00910000"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australas J Ageing"],"published-print":{"date-parts":[[2019,9]]},"abstract":"Objective<\/jats:title>Examine policies of aged care organisations relating to healthcare and lifestyle decision\u2010making.<\/jats:p><\/jats:sec>Methods<\/jats:title>Seven aged care organisations submitted policy documents. Policies were analysed using the Australian Law Reform Commission (ALRC<\/jats:styled-content>) \u201cDecision\u2010Making Principles\u201d as a framework. Senior staff (N\u00a0=\u00a09) with policy development roles participated in follow\u2010up interviews.<\/jats:p><\/jats:sec>Results<\/jats:title>The structure and content of policy documents varied significantly between organisations. Most acknowledged the need to support the rights of care recipients in decision\u2010making; however, the nature of this support was often unclear. Interview themes included factors relating to \u201corganisational contexts\u201d \u201cpolicy development and implementation\u201d and \u201cethical challenges.\u201d An overarching theme among high\u2010performing organisations was \u201cproactive response aimed at pre\u2010empting decision\u2010making dilemmas\u201d. We provide recommendations for policy development, including a self\u2010assessment audit tool.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Aged care provider organisations may need to review policies in the areas of healthcare and lifestyle decision\u2010making to meet current best practice principles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajag.12610","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T06:23:55Z","timestamp":1568010235000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An examination of organisational policies for healthcare and lifestyle decision\u2010making among Australian aged care providers"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2734-2951","authenticated-orcid":false,"given":"Craig","family":"Sinclair","sequence":"first","affiliation":[{"name":"Rural Clinical School of Western Australia (Albany) University of Western Australia (Albany Centre) Albany Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue","family":"Field","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"Blake","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Radoslovich","sequence":"additional","affiliation":[{"name":"Helping Hand Aged Care Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,8]]},"reference":[{"volume-title":"Convention on the Rights of Persons with Disabilities and Optional Protocol","year":"2006","author":"United Nations","key":"e_1_2_8_2_1"},{"volume-title":"Guardianship: Final Report\u00a0No. 24","year":"2012","author":"Victorian Law Reform Commission","key":"e_1_2_8_3_1"},{"volume-title":"Autonomy and Decision\u2010Making Support in Australia: A Targeted Overview of Guardianship Legislation","year":"2014","author":"Office of the Public Advocate (Queensland)","key":"e_1_2_8_4_1"},{"key":"e_1_2_8_5_1","unstructured":"United Nations Enable.Convention on the Rights of Persons with Disabilities Article 12.2008. 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In Pacific-Asia Conference on Knowledge Discovery and Data Mining. Springer, 262--276."},{"key":"e_1_3_2_1_47_1","volume-title":"Manuel Gomez Rogriguez, and Krishna P Gummadi","author":"Zafar Muhammad Bilal","year":"2017","unstructured":"Muhammad Bilal Zafar, Isabel Valera, Manuel Gomez Rogriguez, and Krishna P Gummadi. 2017. Fairness constraints: Mechanisms for fair classification. In Artificial intelligence and statistics. PMLR, 962--970."},{"key":"e_1_3_2_1_48_1","volume-title":"International conference on machine learning. PMLR, 325--333","author":"Zemel Rich","year":"2013","unstructured":"Rich Zemel, Yu Wu, Kevin Swersky, Toni Pitassi, and Cynthia Dwork. 2013. Learning fair representations. In International conference on machine learning. PMLR, 325--333."},{"key":"e_1_3_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1145\/3278721.3278779"},{"key":"e_1_3_2_1_50_1","volume-title":"International Conference on Artificial Intelligence and Statistics. PMLR, 4655--4667","author":"Zhang Yixuan","year":"2023","unstructured":"Yixuan Zhang, Feng Zhou, Zhidong Li, Yang Wang, and Fang Chen. 2023. Fair representation learning with unreliable labels. In International Conference on Artificial Intelligence and Statistics. PMLR, 4655--4667."}],"event":{"name":"CIKM '24: The 33rd ACM International Conference on Information and Knowledge Management","location":"Boise ID USA","acronym":"CIKM '24","sponsor":["SIGIR ACM Special Interest Group on Information Retrieval"]},"container-title":["Proceedings of the 33rd ACM International Conference on Information and Knowledge Management"],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3627673.3679802","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3627673.3679802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:58:07Z","timestamp":1750294687000},"score":7.561182,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3627673.3679802"}},"issued":{"date-parts":[[2024,10,21]]},"references-count":50,"alternative-id":["10.1145\/3627673.3679802","10.1145\/3627673"],"URL":"https:\/\/doi.org\/10.1145\/3627673.3679802","published":{"date-parts":[[2024,10,21]]},"assertion":[{"value":"2024-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:51:34Z","timestamp":1782233494329,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["ID 1046036"],"award-info":[{"award-number":["ID 1046036"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["ID 2015724"],"award-info":[{"award-number":["ID 2015724"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013407","name":"Medela","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020265","name":"Stan Perron Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Breast milk ovalbumin concentrations have been measured with considerable inter\u2010individual variation. Body mass index (BMI) and gestational diabetes mellitus (GDM) in humans, and fish oil supplementation in pigs, have been associated with breast milk protein concentrations. This study aimed to identify whether breast milk ovalbumin concentrations are associated with these maternal characteristics.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This is a secondary analysis of data collected during a randomized trial. Breast milk ovalbumin concentrations were measured in 66 atopic women 2\u20136\u2009h after consumption of one egg at 2, 4, and 6\u2009weeks of lactation. Associations between ovalbumin concentrations and maternal characteristics (BMI, GDM and fish oil supplementation during pregnancy) were investigated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Participants with GDM (\n n<\/jats:italic>\n \u2009=\u20096) had higher ovalbumin concentrations at 2\u2009weeks of lactation (median\u2009=\u20090.87 [IQR 0.27\u20132.17] ng\/mL) compared to participants without GDM (\n n<\/jats:italic>\n \u2009=\u200960, median\u2009=\u20090.15 [IQR 0.05\u20130.67] ng\/mL;\n p<\/jats:italic>\n \u2009=\u2009.03). Participants who consumed fish oil supplements during pregnancy (\n n<\/jats:italic>\n \u2009=\u200916) had higher ovalbumin concentrations at 4\u2009weeks (median\u2009=\u20090.39 [IQR 0.07\u20131.20] ng\/mL) and 6\u2009weeks (median\u2009=\u20090.29 [IQR 0.15\u20130.86] ng\/mL) compared to those who did not (\n n<\/jats:italic>\n \u2009=\u200950, median\u2009=\u20090.05 [IQR 0.05\u20130.44] ng\/mL at 4\u2009weeks,\n p<\/jats:italic>\n \u2009=\u2009.01; and 0.05 [IQR 0.05\u20130.40] ng\/mL at 6\u2009weeks,\n p<\/jats:italic>\n \u2009=\u2009.01). Pre\u2010pregnancy BMI was not associated with ovalbumin concentrations.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n GDM and pregnancy fish oil supplementation were associated with higher breast milk ovalbumin concentrations. Future, larger studies should further investigate associations between these maternal characteristics and breast milk food protein concentrations.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pai.70365","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:24:36Z","timestamp":1778732676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal characteristics associated with ovalbumin concentrations in breast milk"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1570-9480","authenticated-orcid":false,"given":"Sophie A.","family":"Hughes","sequence":"first","affiliation":[{"name":"The Kids Research Institute Australia The University of Western Australia Nedlands Western Australia Australia"},{"name":"School of Molecular Sciences The University of Western Australia Crawley Western Australia Australia"},{"name":"ABREAST Network Perth Western 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Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna T.","family":"Geddes","sequence":"additional","affiliation":[{"name":"School of Molecular Sciences The University of Western Australia Crawley Western Australia Australia"},{"name":"ABREAST Network Perth Western Australia Australia"},{"name":"Centre for Human Lactation Research and Translation The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-8343","authenticated-orcid":false,"given":"Debra J.","family":"Palmer","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia The University of Western Australia Nedlands Western Australia Australia"},{"name":"Centre for Human Lactation Research and Translation The University of Western Australia Crawley Western Australia Australia"},{"name":"School of Medicine The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.01.028"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.70117"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1990.tb02798.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02170.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479388"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12533"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-056925"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2025-108137"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-14-216"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101379"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2015.9.4.433"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16223811"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-025-07412-7"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002507"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.12.029"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12806"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0767"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02028.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-020-0672-9"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2017.0048"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e184"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12411"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9010024"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-023-00710-0"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12803"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.70066"}],"container-title":["Pediatric 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Immunology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.70365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.70365","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.70365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:09:41Z","timestamp":1782230981000},"score":7.561169,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.70365"}},"issued":{"date-parts":[[2026,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/pai.70365"],"URL":"https:\/\/doi.org\/10.1111\/pai.70365","archive":["Portico"],"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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carcinoma on clinical and radiological grounds. This pictorial essay presents the radiological and pathological features of some of these entities.<\/jats:p>","DOI":"10.1111\/1754-9485.12480","type":"journal-article","created":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T11:13:22Z","timestamp":1466507602000},"page":"70-76","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Inflammatory breast disease: A pictorial essay with radiological\u2010pathological correlation"],"prefix":"10.1111","volume":"61","author":[{"given":"Rusiru P","family":"Gunawardena","sequence":"first","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"},{"name":"Prince of Wales Hospital Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika","family":"Gunawardena","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecily","family":"Metcalf","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Taylor","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"},{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liz","family":"Wylie","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital Perth Western Australia Australia"},{"name":"University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2015.06.11"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2012.07.011"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.10551"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.1995.tb00225.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.11.010"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2011.089565"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.41918"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/344463"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.05.048"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12158"},{"key":"e_1_2_12_12_1","volume-title":"Rosen's Breast Pathology","author":"Hoda S","year":"2014"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2013.12.008"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2005.07.003"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.1250"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1754-9485.12480","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1754-9485.12480","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.12480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:57:21Z","timestamp":1695560241000},"score":7.561061,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.12480"}},"issued":{"date-parts":[[2016,6,21]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/1754-9485.12480"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.12480","archive":["Portico"],"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"published":{"date-parts":[[2016,6,21]]},"assertion":[{"value":"2016-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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As well as contributing to proliferation, polyamines are reported to exert an immunosuppressive effect. Amplification of the MYC\/MYCN oncogenes has been shown to directly induce ODC activity and inhibition of this enzyme by \u03b1-difluoromethylornithine (DFMO) markedly delays tumor development. Aminex Therapeutics is developing a polyamine depletion approach targeting both biosynthesis and transport of polyamines with AMX-513, a combination of the approved ODC inhibitor, DFMO, together with AMXT 1501, an alkylated polyamine mimetic which blocks polyamine uptake.<\/jats:p>\n In the syngeneic CT26.CL25 mouse model of colorectal cancer, AMX-513, dosed daily for four weeks, reduced tumor growth &gt; 75% compared to vehicle-treated control in immunocompetent Balb\/C mice. There was no effect in athymic nude mice indicating that tumor growth inhibition by AMX-513 is T-cell-dependent. In the induced transgenic K6\/ODC squamous tumor mouse model, stable regression was sustained 10 weeks after treatment ended and was accompanied by tumor infiltrate increases in IFN\u03b3 and in CD3+ and CD8+ T-cells. Tumor infiltrates from AMX-513-treated KPC pancreatic cancer transgenic mice with tumor regressions showed &gt;90% reductions in myeloid-derived suppressor cells (MDSCs; CD11b+ Gr-1+) but no changes in mature myeloid cells (CD11+Gr-1neg) by FACS analysis. AMX-513 treatment did not impact the percentage or number of CD4+CD25+FoxP3+ Tregs, but did significantly increase the percentage of activated CD8+ T cells in tumors.<\/jats:p>\n Neuroblastoma is an aggressive childhood cancer frequently associated with MYCN and ODC deregulation. In neuroblastoma cell lines, the AMX-513 combination was highly synergistic (CI&lt;0.5). Prophylactic treatment of neuroblastoma-prone TH-MYCN transgenic mice with AMX-513 significantly extended survival compared to either agent alone (median survival time = 81.0\u00b111.8 days versus DFMO alone = 57.1\u00b17.1 days; P&lt;0.0001). Treatment of mice with small palpable tumors with AMX-513 in combination with cyclophosphamide\/topotecan significantly improved survival compared with either AMX-513 or cyclo\/topo alone (5\/9 long term survivors compared to 0\/10 and 0\/9 for cyclo\/topo and AMT-513, respectively; P&lt;0.001 in each case). Polyamine levels were significantly decreased in mice undergoing AMX-513 treatment compared to DFMO or AMXT 1501 alone.<\/jats:p>\n In conclusion, AMX-513 treatment alone or in combination with other cancer therapies results in significant tumor growth reduction in multiple cancer models and demonstrates novel immunotherapeutic potential. Clinical evaluation of AMX-513 is planned in 2017.<\/jats:p>\n Citation Format: Mark R. Burns, Kathy Fosnaugh, Michael G. Palfreyman, Laura Gamble, Jayne Murray, Sophie Allan, Georgina Eden, Sara Sarraf, Murray Norris, David Ziegler, Michelle Haber. AMX-513 polyamine depletion therapy inhibits tumor growth and reverses immunosuppression in cancers including MYC-driven neuroblastoma and pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2006. doi:10.1158\/1538-7445.AM2017-2006<\/jats:p>","DOI":"10.1158\/1538-7445.am2017-2006","type":"journal-article","created":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T21:38:25Z","timestamp":1501537105000},"page":"2006-2006","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Abstract 2006: AMX-513 polyamine depletion therapy inhibits tumor growth and reverses immunosuppression in cancers including MYC-driven neuroblastoma and pancreatic cancer"],"prefix":"10.1158","volume":"77","author":[{"given":"Mark R.","family":"Burns","sequence":"first","affiliation":[{"name":"1Aminex Therpeutics, Inc., Kirkland, WA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Fosnaugh","sequence":"additional","affiliation":[{"name":"2Aminex Therpeutics, Inc., Kenmore, WA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Palfreyman","sequence":"additional","affiliation":[{"name":"1Aminex Therpeutics, Inc., Kirkland, WA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gamble","sequence":"additional","affiliation":[{"name":"3Children's Cancer Institute Australia, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayne","family":"Murray","sequence":"additional","affiliation":[{"name":"3Children's Cancer Institute Australia, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Allan","sequence":"additional","affiliation":[{"name":"3Children's Cancer Institute Australia, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina","family":"Eden","sequence":"additional","affiliation":[{"name":"3Children's Cancer Institute Australia, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Sarraf","sequence":"additional","affiliation":[{"name":"3Children's Cancer Institute Australia, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray","family":"Norris","sequence":"additional","affiliation":[{"name":"3Children's Cancer Institute Australia, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ziegler","sequence":"additional","affiliation":[{"name":"3Children's Cancer Institute Australia, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Haber","sequence":"additional","affiliation":[{"name":"3Children's Cancer Institute Australia, Sydney, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1086","container-title":["Cancer Research"],"language":"en","link":[{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/77\/13_Supplement\/2006\/617541\/Abstract-2006-AMX-513-polyamine-depletion-therapy","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/77\/13_Supplement\/2006\/617541\/Abstract-2006-AMX-513-polyamine-depletion-therapy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T22:15:55Z","timestamp":1656108955000},"score":7.5610285,"resource":{"primary":{"URL":"https:\/\/aacrjournals.org\/cancerres\/article\/77\/13_Supplement\/2006\/617541\/Abstract-2006-AMX-513-polyamine-depletion-therapy"}},"issued":{"date-parts":[[2017,7,1]]},"references-count":0,"journal-issue":{"issue":"13_Supplement","published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1158\/1538-7445.am2017-2006","ISSN":["0008-5472","1538-7445"],"issn-type":[{"value":"0008-5472","type":"print"},{"value":"1538-7445","type":"electronic"}],"published":{"date-parts":[[2017,7,1]]}},{"indexed":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T05:15:17Z","timestamp":1678511717938},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Supplement 4","content-domain":{"domain":["www.auajournals.org"],"crossmark-restriction":true},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1097\/01.ju.0000556521.08083.5e","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T05:40:57Z","timestamp":1556084457000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["MP53-07\u2003PREVALENCE OF LICHEN SCLEROSUS IN MEN PRESENTING FOR CIRCUMCISION"],"prefix":"10.1097","volume":"201","author":[{"given":"Ross","family":"Calopedos*","sequence":"first","affiliation":[{"name":"Port Macquarie, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Richards","sequence":"additional","affiliation":[{"name":"Port Macquarie, 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Urology"],"language":"en","link":[{"URL":"http:\/\/www.auajournals.org\/doi\/pdf\/10.1097\/01.JU.0000556521.08083.5e","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T16:34:05Z","timestamp":1678466045000},"score":7.5605264,"resource":{"primary":{"URL":"http:\/\/www.auajournals.org\/doi\/10.1097\/01.JU.0000556521.08083.5e"}},"issued":{"date-parts":[[2019,4]]},"references-count":0,"journal-issue":{"issue":"Supplement 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dipole forces in optically trapped nanodiamonds containing NV centres, in liquid"],"prefix":"10.1117","volume":"10013","author":[{"given":"Carlo","family":"Bradac","sequence":"additional","affiliation":[{"name":"Macquarie Univ. (Australia)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu L.","family":"Juan","sequence":"additional","affiliation":[{"name":"Macquarie Univ. (Australia)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattias","family":"Johnsson","sequence":"additional","affiliation":[{"name":"Macquarie Univ. (Australia)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Besga","sequence":"additional","affiliation":[{"name":"Macquarie Univ. (Australia)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"van Breugel","sequence":"additional","affiliation":[{"name":"Macquarie Univ. (Australia)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Baragiola","sequence":"additional","affiliation":[{"name":"Macquarie Univ. (Australia)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Martin","sequence":"additional","affiliation":[{"name":"Macquarie Univ. (Australia)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Brennen","sequence":"additional","affiliation":[{"name":"Macquarie Univ. (Australia)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Molina-Terriza","sequence":"additional","affiliation":[{"name":"Macquarie Univ. (Australia)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Volz","sequence":"additional","affiliation":[{"name":"Macquarie Univ. (Australia)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"189","reference":[{"key":"c1","unstructured":"Juan M. L. et.al, arXiv:1511.04665"},{"key":"c2","unstructured":"Bradac C. et al., arXiv:1608.03119"},{"key":"c3","unstructured":"Doherty M. J. et al., Phys. Rep. 2013"},{"key":"c4","unstructured":"Ashkin A., Phys. Rev. Lett. 1970"},{"key":"c5","unstructured":"Ashkin A. et al., Optics Lett. 1986"},{"key":"c6","unstructured":"Grimm R. et al., Adv. In Atomic, Molecular and Optical Phys., 2000"},{"key":"c7","unstructured":"Dicke R. H., Phys. Rev. 1954"},{"key":"c8","unstructured":"Gross M. and Haroche S., Phys. Reps. 1982"},{"key":"c9","unstructured":"Cong K. et al., J.OSA B, 2016"},{"key":"c10","unstructured":"Higgins K. D. B. et al., Nat. Comm. 2014."}],"event":{"name":"SPIE BioPhotonics Australasia","location":"Adelaide, Australia"},"container-title":["SPIE Proceedings","SPIE BioPhotonics Australasia"],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T20:42:40Z","timestamp":1538080960000},"score":7.5604777,"resource":{"primary":{"URL":"http:\/\/proceedings.spiedigitallibrary.org\/proceeding.aspx?doi=10.1117\/12.2242963"}},"editor":[{"given":"Mark R.","family":"Hutchinson","sequence":"first","affiliation":[{"name":"The Univ. of Adelaide (Australia)"}],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Ewa M.","family":"Goldys","sequence":"additional","affiliation":[{"name":"Macquarie Univ. (Australia)"}],"role":[{"role":"editor","vocabulary":"crossref"}]}],"issued":{"date-parts":[[2016,12,9]]},"references-count":10,"URL":"https:\/\/doi.org\/10.1117\/12.2242963","ISSN":["0277-786X"],"issn-type":[{"type":"print","value":"0277-786X"}],"published":{"date-parts":[[2016,12,9]]}},{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:42:54Z","timestamp":1784306574391,"version":"3.55.0"},"reference-count":24,"publisher":"BMJ","issue":"12","funder":[{"DOI":"10.13039\/501100000960","name":"Healthway","doi-asserted-by":"publisher","award":["N\/A- no grant number was provided by the funding b"],"award-info":[{"award-number":["N\/A- no grant number was provided by the funding b"]}],"id":[{"id":"10.13039\/501100000960","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council Western Australia","doi-asserted-by":"publisher","award":["N\/A- no grant number was provided by the funding b"],"award-info":[{"award-number":["N\/A- no grant number was provided by the funding b"]}],"id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001801","name":"University of Western Australia","doi-asserted-by":"publisher","award":["ARC DECRA Fellowship (DE210101791)."],"award-info":[{"award-number":["ARC DECRA Fellowship (DE210101791)."]}],"id":[{"id":"10.13039\/501100001801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Epidemiol Community Health"],"accepted":{"date-parts":[[2021,6,22]]},"published-print":{"date-parts":[[2021,12]]},"abstract":"\n Background<\/jats:title>\n Food marketing exposure has the potential to influence children\u2019s dietary behaviours and health status, however, few studies have identified how \u2018obesogenic\u2019 the outdoor food marketing environment is along public transport (bus and\/or train) or walking routes that children take to school.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Audits of all outdoor advertisements present along likely train, bus and walking routes to 24 secondary schools (ie, 3 routes per school, 72 routes total) were conducted in Perth, Western Australia (WA). The size, content, type and setting of each advertisement were recorded in accordance with the International Network for Food and Obesity\/non-communicable diseases Research, Monitoring and Action Support protocol for monitoring outdoor advertising.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of the 4016 total advertisements observed, almost half were for food (n=1754, 44%) and of these, 80% (n=1397) advertised discretionary (non-core) foods, and 8% (n=138) advertised healthy (core) foods. On average, commuting to school by train, bus and walking exposed Perth schoolchildren to 37.1, 22 and 4.5 discretionary (non-core) food ads per one-way trip to school, respectively.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Children living in Perth, WA experience a high level of exposure to unhealthy outdoor food advertisements during the school commute. Policies which restrict the placement and content of outdoor advertising, could be a useful strategy in the fight against childhood obesity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/jech-2021-217032","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T11:30:11Z","timestamp":1626694211000},"page":"1232-1235","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Exposure to unhealthy food and beverage advertising during the school commute in Australia"],"prefix":"10.1136","volume":"75","author":[{"given":"Gina","family":"Trapp","sequence":"first","affiliation":[{"name":"Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Hooper","sequence":"additional","affiliation":[{"name":"The University of Western Australia School of Design, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukar E","family":"Thornton","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity and Nutrition Research, Deakin University, Burwood, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Kennington","sequence":"additional","affiliation":[{"name":"Cancer Council Western Australia, Subiaco, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainslie","family":"Sartori","sequence":"additional","affiliation":[{"name":"Cancer Council Western Australia, Subiaco, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7202-7187","authenticated-orcid":false,"given":"Nicole","family":"Wickens","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley","family":"Billingham","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"2025100704095806000_75.12.1232.1","unstructured":"Pikora T , Christian H , Trapp G , et al . Chronic disease prevention interventions in children and young adults: a rapid review prepared for the Australian government department of health on behalf of the Australian prevention partnership centre, 2016."},{"key":"2025100704095806000_75.12.1232.2","unstructured":"World Health Organization . Global action plan for the prevention and control of noncommunicable diseases 2013-2020. Geneva, Switzerland: WHO, 2013."},{"key":"2025100704095806000_75.12.1232.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2012.01.032"},{"key":"2025100704095806000_75.12.1232.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2012.04.017"},{"key":"2025100704095806000_75.12.1232.5","doi-asserted-by":"publisher","DOI":"10.1037\/a0014399"},{"key":"2025100704095806000_75.12.1232.6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.031308.100304"},{"key":"2025100704095806000_75.12.1232.7","doi-asserted-by":"crossref","DOI":"10.3390\/nu11040875","article-title":"Food marketing influences children\u2019s attitudes, preferences and consumption: A systematic critical review","volume":"11","author":"Smith","year":"2019","journal-title":"Nutrients"},{"key":"2025100704095806000_75.12.1232.8","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1017\/S1368980007001231","article-title":"Beyond-brand effect of television food advertisements on food choice in children: the effects of weight status","volume":"11","author":"Halford","year":"2008","journal-title":"Public Health Nutr"},{"key":"2025100704095806000_75.12.1232.9","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980013001067"},{"key":"2025100704095806000_75.12.1232.10","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/pubmed\/fdx004","article-title":"Advertising to children initiatives have not reduced unhealthy food advertising on Australian television","volume":"39","author":"Watson","year":"2017","journal-title":"J Public Health"},{"key":"2025100704095806000_75.12.1232.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-6405.2008.00303.x"},{"key":"2025100704095806000_75.12.1232.12","article-title":"Advertising and availability of 'obesogenic' foods around New Zealand secondary schools: a pilot study","volume":"118","author":"Maher","year":"2005","journal-title":"N Z Med J"},{"key":"2025100704095806000_75.12.1232.13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/hpja.55","article-title":"The volume and type of unhealthy bus shelter advertising around schools in Perth, Western Australia: results from an explorative study","volume":"30","author":"Parnell","year":"2019","journal-title":"Health Promot J Austr"},{"key":"2025100704095806000_75.12.1232.14","doi-asserted-by":"publisher","DOI":"10.1080\/13557850802307809"},{"key":"2025100704095806000_75.12.1232.15","doi-asserted-by":"crossref","DOI":"10.1186\/s12889-017-4433-2","article-title":"An audit of food and beverage advertising on the Sydney metropolitan train network: regulation and policy implications","volume":"17","author":"Sainsbury","year":"2017","journal-title":"BMC Public Health"},{"key":"2025100704095806000_75.12.1232.16","unstructured":"Trapp G , Hooper P . Junk food filled neighbourhoods: building a local evidence base for change. The Univeristy of Western Australia, Telethon Kids Institute, Centre for Child Health Research, 2020."},{"key":"2025100704095806000_75.12.1232.17","doi-asserted-by":"crossref","DOI":"10.17061\/phrp3012005","article-title":"Children's trips to school dominated by unhealthy food advertising in Sydney, Australia","volume":"30","author":"Richmond","year":"2020","journal-title":"Public Health Res Pract"},{"key":"2025100704095806000_75.12.1232.18","unstructured":"Outdoor Media Association . Industry performance, 2017. Available: http:\/\/www.oma.org.au\/"},{"key":"2025100704095806000_75.12.1232.19","unstructured":"Department of Education . Alphabetical list of Western Australian schools. Government of Western Australia, 2021."},{"key":"2025100704095806000_75.12.1232.20","unstructured":"The University of Auckland . International Network for Food and Obesity \/ non-communicable Diseases Research Monitoring and Action Support. INFORMAS protocol: Promotion - Outdoor advertising (School zones), 2017."},{"key":"2025100704095806000_75.12.1232.21","doi-asserted-by":"publisher","DOI":"10.1111\/1753-6405.12257"},{"key":"2025100704095806000_75.12.1232.22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.5694\/j.1326-5377.2011.tb03182.x","article-title":"Advertising of fast food to children on Australian television: the impact of industry self-regulation","volume":"195","author":"Hebden","year":"2011","journal-title":"Med J Aust"},{"key":"2025100704095806000_75.12.1232.23","unstructured":"Watson W , Johnston A , Hughes C , et al . Children\u2019s health or corporate wealth? The battleground for kids\u2019 hearts, minds and tummies. Sydney: Cancer Council New South Wales, 2014."},{"key":"2025100704095806000_75.12.1232.24","unstructured":"Backholer K , Chung A , Zorbas C . Unhealthy food and beverage advertising in outdoor spaces and on publicly owned assets: a scoping review of the literature. Cancer Council Western Australia, 2020."}],"container-title":["Journal of Epidemiology and Community Health"],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jech-2021-217032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T11:10:12Z","timestamp":1759835412000},"score":7.5604396,"resource":{"primary":{"URL":"https:\/\/jech.bmj.com\/lookup\/doi\/10.1136\/jech-2021-217032"}},"issued":{"date-parts":[[2021,7,19]]},"references-count":24,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,11,10]]},"published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1136\/jech-2021-217032"],"URL":"https:\/\/doi.org\/10.1136\/jech-2021-217032","ISSN":["0143-005X","1470-2738"],"issn-type":[{"value":"0143-005X","type":"print"},{"value":"1470-2738","type":"electronic"}],"published":{"date-parts":[[2021,7,19]]}},{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T15:26:13Z","timestamp":1771255573176,"version":"3.50.1"},"reference-count":118,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Global Change Biology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n Global warming has induced more years of above\u2010average rainfall, significantly affecting the interannual variability of the terrestrial global carbon cycle. An extreme wet year can cause changes to vegetation structure and function that persist beyond itself, referred to as \u201clegacy effects\u201d. The physical and biological mechanisms underlying these effects are poorly understood, introducing uncertainty into climate\u2013carbon models to accurately represent post\u2013wet year vegetation dynamics. Here we used multi\u2010source satellite\u2010derived vegetation productivity metrics, as well as eddy covariance (EC) measurements, to investigate the legacy effects of extreme wet years on the productivity of Australia's drylands. We found that the impact of the 2010\u20132011 extreme wet year extended beyond generating a record\u2010breaking carbon uptake, which exceeded the 40\u2010year mean by more than 1.5 standard deviations. It also resulted in a widespread positive legacy effect in the following year. Specifically, up to 56% of the vegetated areas that experienced anomalous wetness showed significant legacy effects after 1\u2009year, with impact size contributing up to 40% of total productivity in those regions. Biological memory in wet years, representing a potential process for carbon storage and subsequent remobilization, was shown to dominate the legacy effect. Random forest analysis identified key ecogeographic controls on biological memory, such as resource\u2010conservative strategies associated with drier climates and relatively fertile soils. Comparisons with Dynamic Global Vegetation Models (DGVMs) further revealed that current models may underestimate this biological memory by up to 70%, in part due to limited representation of carbon storage dynamics. 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However, MMS can be prolonged; thus reinjections of local anesthetics are often required.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVE<\/jats:title>\n Is 0.5% bupivacaine with 1:200,000 epinephrine a useful adjunctive treatment when compared with the use of 1% lidocaine with 1:100,000 epinephrine in MMS for the nose?<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Participants undergoing MMS received 2.5 mL of 1% lidocaine with 1:100,000 epinephrine before commencement of Stage 1. At the end of Stage 1, participants were randomized sequentially to either 2.5 mL 0.5% bupivacaine with 1:200,000 epinephrine (Group A) or 2.5 mL of 1% lidocaine with 1:100,000 epinephrine (Group B). Effectiveness of anesthesia was assessed using 30 G needle to 5 points of the wound before further stage or repair.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Fifty-one patients were randomized, 26 to Group A, and 25 to Group B. No differences between the 2 groups in size of defect and time lapse between time of injection and time of testing were observed. Seven of 25 were tested positive in Group B. Zero of 26 tested positive in Group A (p<\/jats:italic> = .003, 95% confidence interval: 10%\u201346%).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n Adjunctive use of 0.5% bupivacaine with 1:200,000 epinephrine is effective in prolonging anesthesia in MMS.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/dss.0000000000001385","type":"journal-article","created":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T19:58:46Z","timestamp":1510689526000},"page":"607-610","source":"Crossref","is-referenced-by-count":14,"title":["Bupivacaine as an Adjunct to Lidocaine in Mohs Micrographic Surgery: A Prospective Randomized Controlled Trial"],"prefix":"10.1097","volume":"44","author":[{"given":"Peggy","family":"Chen","sequence":"first","affiliation":[{"name":"Oxford Dermatology, Mt Hawthorn, Western Australia, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey","family":"Smith","sequence":"additional","affiliation":[{"name":"Oxford Dermatology, Mt Hawthorn, Western Australia, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Vinciullo","sequence":"additional","affiliation":[{"name":"Oxford Dermatology, Mt Hawthorn, Western Australia, Australia;"},{"name":"Royal Perth Hospital, Perth, Western Australia, Australia;"},{"name":"University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230814","first-page":"294","article-title":"Practical comments on the use and abuse of cocaine; suggested by its invariably successful employment in more than a thousand minor surgical operations","volume":"xlii","author":"Halsted","year":"1885","journal-title":"N Y Med J"},{"key":"R2-20230814","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1524-4725.1988.tb03340.x","article-title":"Anesthesia for dermatologic surgery (review)","volume":"14","author":"Winton","year":"1988","journal-title":"J 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Surg Oncol"},{"issue":"Suppl 1","key":"R9-20230814","doi-asserted-by":"crossref","first-page":"S230","DOI":"10.4103\/0975-7406.155921","article-title":"Bupivacaine versus lignocaine as the choice of local anesthetic agent for impacted third molar surgery a review","volume":"7","author":"Balakrishnan","year":"2015","journal-title":"J Pharm Bioallied Sci"},{"key":"R10-20230814","first-page":"1486","article-title":"Oral antibiotics versus topical decolonisation to prevent surgical site infection after Mohs micrographic sugery\u2014a randomised, controlled trial","volume":"39","author":"Cherian","year":"2013","journal-title":"Dermatol Surg"},{"key":"R11-20230814","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S1470-2045(08)70260-2","article-title":"Surgical excision versus Mohs micrographic surgery for primary and recurrent basal cell carcinoma of the face: a prospective randomised controlled trial with 5-years 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Our understanding of the underlying drivers of differential responses to ocean acidification is currently limited by difficulties in directly observing and quantifying the mechanisms of bio\u2010calcification. Here, we present Raman spectroscopy techniques for characterizing the skeletal mineralogy and calcifying fluid chemistry of marine calcifying organisms such as corals, coralline algae, foraminifera, and fish (carbonate otoliths). First, our in vivo Raman technique is the ideal tool for investigating non\u2010classical mineralization pathways. This includes calcification by amorphous particle attachment, which has recently been controversially suggested as a mechanism by which corals resist the negative effects of ocean acidification. Second, high\u2010resolution ex vivo Raman mapping reveals complex banding structures in the mineralogy of marine calcifiers, and provides a tool to quantify calcification responses to environmental variability on various timescales from days to years. 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Exper Ophthalmology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>To date, our understanding of the biochemical composition of the living human vitreous relies on extrapolations from animal or human post\u2010mortem studies.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a cross\u2010sectional study of vitreous samples from 27 individuals scheduled for retinal surgery within a tertiary hospital. From each vitreous sample, the concentrations of sodium, potassium, chloride, calcium, magnesium, glucose, lactate, \u03b2\u2010 hydroxybutyrate, copper, zinc, selenium, iron, ferritin and transferrin and osmolality were measured. Perioperative serum samples were also obtained for comparison.<\/jats:p><\/jats:sec>Results<\/jats:title>The following vitreous mean\u2009\u00b1\u2009standard deviation (95% confidence interval of the mean) was observed for each analyte: sodium, 146.7\u2009\u00b1\u20093.3 (145.4\u2013148.0) mmol\/L; potassium, 5.73\u2009\u00b1\u20090.86 (5.39\u20136.08) mmol\/L; chloride, 121.6\u2009\u00b1\u20092.6 (120.6\u2013122.7) mmol\/L; calcium, 1.128\u2009\u00b1\u20090.518 (0.923\u20131.333) mmol\/L; magnesium, 0.900\u2009\u00b1\u20090.158 (0.838\u20130.962) mmol\/L; glucose, 2.97\u2009\u00b1\u20090.98 (2.58\u20133.36) mmol\/L; lactate, 3.97\u2009\u00b1\u20091.09 (3.54\u20134.40) mmol\/L; osmolality, 289.5\u2009\u00b1\u20096.9 (286.6\u2013292.5) mOsm\/kg; BOHB, 0.0937\u2009\u00b1\u20090.0472 (0.0750\u20130.1124) mmol\/L; copper, 0.519\u2009\u00b1\u20090.269 (0.412\u20130.625) \u00b5mol\/L; zinc, 1.95\u2009\u00b1\u20091.09 (1.52\u20132.38) \u00b5mol\/L; selenium, 0.1035\u2009\u00b1\u20090.0276 (0.0923\u20130.1146) \u00b5mol\/L; iron, 3.11\u2009\u00b1\u20091.40 (2.56\u20133.66) \u00b5mol\/L; ferritin, 19.5\u2009\u00b1\u200910.3 (15.5\u201323.6) \u00b5g\/L; transferrin, 0.0878\u2009\u00b1\u20090.0526 (0.0670\u20130.1086) g\/L. Vitreous biochemistry was not significantly different between male and female participants. Vitreous biochemistry was significantly different between non\u2010diabetic and diabetic participants. Vitreous biochemistry was significantly different from the vitreous substitute BSS Plus (Alcon, USA). The vitreous extracted from living humans was markedly different from the commonly reported reference values obtained from animal studies.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The current data provide hitherto unavailable information about the biochemical composition of the living human vitreous.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.12732","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:05:05Z","timestamp":1455840305000},"page":"597-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Biochemical analysis of the living human vitreous"],"prefix":"10.1111","volume":"44","author":[{"given":"Jan","family":"Kokavec","sequence":"first","affiliation":[{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San H","family":"Min","sequence":"additional","affiliation":[{"name":"University of 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Patients who do not meet the PBS criteria can obtain TCZ through public hospital individual patient use (IPU) schemes which may not be universally accessible. We compared patients receiving IPU\u2010approved TCZ with patients receiving PBS\u2010subsidised TCZ and found IPU approvals were granted mainly for visual loss, a serious complication of GCA, in patients who otherwise failed to meet PBS criteria. Further studies demonstrating that TCZ is comparatively more effective than prednisolone monotherapy, as well as cost\u2010effective, are needed to substantiate the rationale for expanding PBS approval criteria.<\/jats:p>","DOI":"10.1111\/imj.16419","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T10:09:32Z","timestamp":1719914972000},"page":"1228-1232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tocilizumab use in giant cell arteritis: comparing Pharmaceutical Benefits Scheme<\/scp> eligible and ineligible cases in South Australia"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6042-5030","authenticated-orcid":false,"given":"Lucinda","family":"Robinson","sequence":"first","affiliation":[{"name":"Rheumatology Unit Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maddison","family":"Hamden","sequence":"additional","affiliation":[{"name":"Pharmacy Department Central Adelaide Local Health Network Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Griggs","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumu","family":"Simon","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-4922","authenticated-orcid":false,"given":"Catherine","family":"Hill","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"},{"name":"Rheumatology Unit The Queen Elizabeth Hospital Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidya","family":"Limaye","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Proudman","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Royal Adelaide Hospital Adelaide South Australia Australia"},{"name":"University of Adelaide Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/AITC201611010"},{"key":"e_1_2_4_3_1","first-page":"1","article-title":"Disease stratification in GCA and PMR: state of the art and future perspectives","volume":"12","author":"Tomelleri A","year":"2023","journal-title":"Nat Rev Rheumatol"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200104)45:2<140::AID-ANR166>3.0.CO;2-2"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588411X12851639107476"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41774"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613849"},{"key":"e_1_2_4_8_1","unstructured":"Australian Government Department of Health and Aged Care.The Pharmaceutical Benefits Scheme Tocilizumab [Internet]. Canberra: Department of Health and Aged Care [Cited 2024 Apr 7]. Available from URL:https:\/\/www.pbs.gov.au\/medicine\/item\/11565Q-11567T-11722Y-11725D-11734N-11742B-11744D-11750K-12083Y-12084B-12085C-12090H-12094M-12761P-12767Y-12792G-13306H-13720D."},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000001645"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X221113747"}],"container-title":["Internal Medicine 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Dementia"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.jalz.2010.05.1987","type":"journal-article","created":{"date-parts":[[2010,7,11]],"date-time":"2010-07-11T21:03:24Z","timestamp":1278882204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["P3\u2010445: Fitness for the aging brain study II: A multisite randomized controlled trial to determine the clinical benefits of physical activity for patients with mild\u2010to\u2010moderate Alzheimer's disease"],"prefix":"10.1002","volume":"6","author":[{"given":"Elizabeth V.","family":"Cyarto","sequence":"first","affiliation":[{"name":"National Ageing Research Institute Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muireann","family":"Irish","sequence":"additional","affiliation":[{"name":"National Ageing Research Institute Melbourne 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Health Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard J.","family":"Byrne","sequence":"additional","affiliation":[{"name":"The University of Queensland Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana","family":"Appadurai","sequence":"additional","affiliation":[{"name":"The University of Queensland Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Beer","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"LoGiudice","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Renehan","sequence":"additional","affiliation":[{"name":"National Ageing Research Institute Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran","family":"Waddell","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Hughes","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola T.","family":"Lautenschlager","sequence":"additional","affiliation":[{"name":"University of Western Australia Perth Australia"},{"name":"The University of Melbourne Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7]]},"container-title":["Alzheimer's & Dementia"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526010021072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526010021072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.jalz.2010.05.1987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2010.05.1987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.jalz.2010.05.1987","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2010.05.1987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:37:44Z","timestamp":1759937864000},"score":7.5587435,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1016\/j.jalz.2010.05.1987"}},"issued":{"date-parts":[[2010,7]]},"references-count":0,"journal-issue":{"issue":"4S_Part_19","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1016\/j.jalz.2010.05.1987"],"URL":"https:\/\/doi.org\/10.1016\/j.jalz.2010.05.1987","archive":["Portico"],"ISSN":["1552-5260","1552-5279"],"issn-type":[{"type":"print","value":"1552-5260"},{"type":"electronic","value":"1552-5279"}],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"2010-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T04:31:13Z","timestamp":1690432273660},"reference-count":0,"publisher":"British Editorial Society of Bone & Joint Surgery","issue":"SUPP_8","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/boneandjoint.org.uk\/TDM"}],"content-domain":{"domain":["boneandjoint.org.uk"],"crossmark-restriction":true},"short-container-title":["Bone Joint J"],"published-print":{"date-parts":[[2023,4,11]]},"abstract":"Tendinopathy is the most frequent musculoskeletal disease that requires medical attention. Mechanical overload has been considered as a key driver of its pathology. However, the underline mechanism on how overload induces tendinopathy and inflammation is unclear. Extracellular mitochondria (EM) are newly identified as cell-to-cell communicators. The aim of this study is to elucidate the role of mitochondria in overload-induced inflammation.<\/jats:p>We performed three-dimensional uniaxial stretching to mouse tendon organoid in bioreactors. Cyclic strain of uniaxial loadings included underload, normal load, and overload, according to previous work. We then harvested microvesicles including EM, from the bioreactor by differential centrifugation and evaluated their characteristics by flow cytometry and super-resolution confocal microscopy. Raw 264.7 mouse macrophage cell line was used for chemotaxis assay in a Boyden Chamber System with Magnetic-Activated Cell Sorting Technology. EM induced cytokines secretion by macrophages was analyzed by a bead-based multiplex assay panel. N-Acetyl-L-cysteine (NAC) was used as the antioxidant to tendon organoid to regulate mitochondrial fitness.<\/jats:p>We showed mechanical load induced tendon organoid to release microvesicles including mitochondria. The size of microvesicles is mainly in the range from 220nm to 880nm. More than 75% of microvesicles could be stained by PKH26, confirming they were with lipophilic membrane. Super-resolution confocal microscopy identified two forms of mitochondria, including mitochondria encapsulated in vesicles and free mitochondria. Overload led to the degeneration of the organoid and induced microvesicles release containing most EM. Chemotaxis assay showed that EM from overloaded tendon organoid induced macrophages chemotaxis. In addition, microvesicles extracted from overloaded tendon organoid induced the production of proinflammatory cytokines including IL-6, KC (Keratinocyte-Derived Chemokine) and IL-18. NAC treatment to tendon cells could attenuate overload-induced macrophage chemotaxis.<\/jats:p>Overload induces EM releasing from tendon cells, which leads to chemotaxis of macrophages toward tendon, resulting in induction of inflammation.<\/jats:p>","DOI":"10.1302\/1358-992x.2023.8.014","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T13:18:36Z","timestamp":1690377516000},"page":"14-14","update-policy":"http:\/\/dx.doi.org\/10.1302\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["OVERLOAD-INDUCED EXTRACELLULAR MITOCHONDRIA RELEASING FROM TENDON ORGANOID LEADS TO INFLAMMATION"],"prefix":"10.1302","volume":"105-B","author":[{"given":"Z.","family":"Chen","sequence":"first","affiliation":[{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Chen","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tai","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Bassonga","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wang","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zheng","sequence":"additional","affiliation":[{"name":"The University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"42","published-online":{"date-parts":[[2023,4,11]]},"container-title":["Orthopaedic Proceedings"],"language":"en","link":[{"URL":"https:\/\/boneandjoint.org.uk\/doi\/10.1302\/1358-992X.2023.8.014\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/boneandjoint.org.uk\/doi\/10.1302\/1358-992X.2023.8.014\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/boneandjoint.org.uk\/doi\/pdf\/10.1302\/1358-992X.2023.8.014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T13:18:38Z","timestamp":1690377518000},"score":7.55865,"resource":{"primary":{"URL":"https:\/\/boneandjoint.org.uk\/doi\/10.1302\/1358-992X.2023.8.014"}},"issued":{"date-parts":[[2023,4,11]]},"references-count":0,"journal-issue":{"issue":"SUPP_8","published-online":{"date-parts":[[2023,4,11]]},"published-print":{"date-parts":[[2023,4,11]]}},"alternative-id":["10.1302\/1358-992X.2023.8.014"],"URL":"https:\/\/doi.org\/10.1302\/1358-992x.2023.8.014","ISSN":["1358-992X","2049-4416"],"issn-type":[{"value":"1358-992X","type":"print"},{"value":"2049-4416","type":"electronic"}],"published":{"date-parts":[[2023,4,11]]},"assertion":[{"value":"2023-4-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:30:07Z","timestamp":1784158207846,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Rural Health"],"published-print":{"date-parts":[[2025,3]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>In Australia, there is limited research regarding the effect of rurality on health care utilization using longitudinal data.<\/jats:p><\/jats:sec>Methods<\/jats:title>We analyzed data from four annual waves (2009, 2013, 2017, and 2021) of the longitudinal Household, Income and Labour Dynamics in Australia (HILDA) Survey to examine changes in the health care utilization over time among urban and rural residents. Poisson regression models estimated adjusted incidence rate ratios (aIRR) and 95% confidence intervals (CIs) for rural versus urban residents, accounting for a range of health\u2010related and sociodemographic characteristics. Health care utilization was measured using four key indicators: visits to family doctor or another general practitioner\u00a0(GP visits from hereon), hospital admissions, total nights' stay in the hospital, and prescribed medications taken on a regular basis.<\/jats:p><\/jats:sec>Results<\/jats:title>The aIRR for GP visits among rural versus urban Australian residents increased over time, from 0.89 (95% CI: 0.82 to 0.97) in 2009 to 0.96 (95% CI: 0.89 to 1.04) in 2021 although not consistently increased in a statistically significant manner. While there were no consistent temporal patterns, our analysis found that rural residents experienced higher number of hospital admissions (aIRR, 1.12 to 1.15) and number of nights in the hospital in the last 12 months (aIRR, 1.18 to 1.25) compared to urban residents. Moreover, rurality had little to no effect on the number of prescribed medications taken on a regualar basis\u00a0in the 12 months preceding the HILDA Surveys in 2013, 2017, and 2021.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This study found that GP visits were less frequent among rural residents compared to metropolitan residents in 2009, indicating health care access disparities between rural and urban areas in Australia. However, the differences in GP visits between rural and urban areas were less pronounced\u00a0 from 2013 to 2021.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jrh.12884","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T04:33:21Z","timestamp":1728016401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of rurality on health care utilization among Australian residents from 2009 to 2021"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0703-1515","authenticated-orcid":false,"given":"Engida","family":"Yisma","sequence":"first","affiliation":[{"name":"Department of Rural Health University of South Australia Whyalla Norrie and Mount Barker South Australia Australia"},{"name":"IIMPACT in Health University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Rural Health University of South Australia Whyalla Norrie and Mount Barker South Australia Australia"},{"name":"IIMPACT in Health University of South Australia Adelaide South Australia Australia"},{"name":"School of Nursing and Midwifery Edith Cowan University South West Campus Bunbury Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee San","family":"Pauh","sequence":"additional","affiliation":[{"name":"Department of Rural Health University of South Australia Whyalla Norrie and Mount Barker South Australia Australia"},{"name":"IIMPACT in Health University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Rural Health University of South Australia Whyalla Norrie and Mount Barker South Australia Australia"},{"name":"IIMPACT in Health University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Rural Health University of South Australia Whyalla Norrie and Mount Barker South Australia Australia"},{"name":"IIMPACT in Health University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"May","sequence":"additional","affiliation":[{"name":"IIMPACT in Health University of South Australia Adelaide South Australia Australia"},{"name":"Department of Clinical and Health Sciences University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Gillam","sequence":"additional","affiliation":[{"name":"Department of Rural Health University of South Australia Whyalla Norrie and Mount Barker South Australia Australia"},{"name":"IIMPACT in Health University of South Australia Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Institute of Medicine Committee on Monitoring Access to Personal Health Care Services, Millman M, National Academy of Sciences. 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Pursuit. Accessed August 13 2024.https:\/\/www.pursuitunimelbeduau\/articles\/we\u2010aren\u2010t\u2010all\u2010equal\u2010when\u2010it\u2010comes\u2010to\u2010climate\u2010vulnerability2024"}],"container-title":["The Journal of Rural Health"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jrh.12884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T12:54:49Z","timestamp":1750337689000},"score":7.5585017,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jrh.12884"}},"issued":{"date-parts":[[2024,10,3]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/jrh.12884"],"URL":"https:\/\/doi.org\/10.1111\/jrh.12884","archive":["Portico"],"ISSN":["0890-765X","1748-0361"],"issn-type":[{"value":"0890-765X","type":"print"},{"value":"1748-0361","type":"electronic"}],"published":{"date-parts":[[2024,10,3]]},"assertion":[{"value":"2024-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12884"},{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:11:27Z","timestamp":1778915487939,"version":"3.51.4"},"reference-count":111,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental DNA"],"published-print":{"date-parts":[[2025,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Although environmental DNA (eDNA) metabarcoding has become a widespread tool used by ecologists to monitor wildlife diversity, there have been few applications of the approach for impact assessments. Here we use eDNA collected in a before\u2013after, control\u2010impact (BACI) experimental design to determine if the noise produced by a large\u2010scale seismic survey modified the fish community on a tropical shelf. We compared abundance estimates of fishes calculated using metrics that included eDNA counts and an eDNA index of relative abundance (a proportional metric) with estimates sampled using baited remote underwater video stations (BRUVS). In total, we detected 102 different genera of fishes using the BRUVS and eDNA datasets combined, although there were more genera observed using BRUVS (\n n<\/jats:italic>\n \u2009=\u200971) than with eDNA metabarcoding (\n n<\/jats:italic>\n \u2009=\u200957). There was a weak positive relationship between the estimates of relative abundance sampled using BRUVS and eDNA counts when data from common genera were combined, although relationships at the genera level were inconsistent. We found no evidence of major change in the community structure of fishes at the high impact zone of the seismic survey compared to control zones. This result was confirmed using metrics across fish taxa within the BACI framework, suggesting no material impacts to species richness or abundance due to the seismic survey. The power to detect change in the fish community structure and abundance was high (99% probability) for detecting an 80% change in all metrics tested; however, it was considerably lower for detecting smaller changes. Our study highlights the utility and applicability of eDNA metabarcoding to assess point\u2010source impacts on fish communities, particularly when used in parallel with other techniques such as BRUVS.\n <\/jats:p>","DOI":"10.1002\/edn3.70190","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T11:29:39Z","timestamp":1758022179000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Use of Environmental\n DNA<\/scp>\n Metabarcoding to Assess the Impacts of a Large\u2010Scale Seismic Survey on Tropical Fish Communities"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3186-8710","authenticated-orcid":false,"given":"Conrad W.","family":"Speed","sequence":"first","affiliation":[{"name":"Australian Institute of Marine Science Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Dugal","sequence":"additional","affiliation":[{"name":"Australian Institute of Marine Science Perth Western Australia Australia"},{"name":"UWA Oceans Institute The University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark G.","family":"Meekan","sequence":"additional","affiliation":[{"name":"Australian Institute of Marine Science Perth Western Australia Australia"},{"name":"UWA Oceans Institute The University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Birt","sequence":"additional","affiliation":[{"name":"Australian Institute of Marine Science Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miles","family":"Parsons","sequence":"additional","affiliation":[{"name":"Australian Institute of Marine Science Perth Western Australia Australia"},{"name":"UWA Oceans Institute The University of Western Australia Perth Western Australia Australia"},{"name":"Centre for Marine Science and Technology Curtin University Bentley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne","family":"McLean","sequence":"additional","affiliation":[{"name":"Australian Institute of Marine Science Perth Western Australia Australia"},{"name":"UWA Oceans Institute The University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett","family":"Taylor","sequence":"additional","affiliation":[{"name":"Australian Institute of Marine Science Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"McCauley","sequence":"additional","affiliation":[{"name":"Centre for Marine Science and Technology Curtin University Bentley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayson M.","family":"Semmens","sequence":"additional","affiliation":[{"name":"Institute for Marine and Antarctic Studies University of Tasmania Hobart Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Newman","sequence":"additional","affiliation":[{"name":"Western Australian Fisheries and Marine Research Laboratories, Department of Primary Industries and Regional Development Government of Western Australia North Beach Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Fisher","sequence":"additional","affiliation":[{"name":"Australian Institute of Marine Science Perth Western Australia Australia"},{"name":"UWA Oceans Institute The University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Thomas","sequence":"additional","affiliation":[{"name":"Australian Institute of Marine Science Perth Western Australia Australia"},{"name":"UWA Oceans Institute The University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2023.1222523"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.15661"},{"key":"e_1_2_11_4_1","volume-title":"For PRIMER: Guide to Software and Statistical Methods","author":"Anderson 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S.Yoon A.Kasai et\u00a0al.2019. \u201cDispersion and Degradation of Environmental DNA From Caged Fish in a Marine Environment.\u201d88 no.4:529\u2013530.","DOI":"10.1007\/s12562-022-01612-2"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124671"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/edn3.93"},{"issue":"9","key":"e_1_2_11_72_1","first-page":"1","article-title":"Package \u2018Vegan\u2019","volume":"2","author":"Oksanen J.","year":"2013","journal-title":"Community Ecology Package, Version"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpol.2016.12.017"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/icesjms\/fst079"},{"key":"e_1_2_11_75_1","first-page":"170","volume-title":"Anthropogenic Sound and Fishes","author":"Popper A.","year":"2019"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.2009.02319.x"},{"key":"e_1_2_11_77_1","volume-title":"ASA S3\/SC1. 4 TR\u20102014 Sound Exposure Guidelines for Fishes and Sea Turtles: A Technical Report Prepared by ANSI\u2010Accredited Standards Committee S3\/SC1 and Registered With ANSI","author":"Popper A. N.","year":"2014"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0025315400047615"},{"key":"e_1_2_11_79_1","volume-title":"A Language and Environment for Statistical Computing","author":"R\u2010Core Team","year":"2022"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2664.12306"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/edn3.185"},{"key":"e_1_2_11_82_1","first-page":"216","article-title":"Estimated Marginal Means, Aka Least\u2010Squares Means","volume":"34","author":"Russell L.","year":"2018","journal-title":"American 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DNA"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/edn3.70190","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/edn3.70190","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/edn3.70190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:38:04Z","timestamp":1778913484000},"score":7.5585017,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/edn3.70190"}},"issued":{"date-parts":[[2025,9]]},"references-count":111,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/edn3.70190"],"URL":"https:\/\/doi.org\/10.1002\/edn3.70190","archive":["Portico"],"ISSN":["2637-4943","2637-4943"],"issn-type":[{"value":"2637-4943","type":"print"},{"value":"2637-4943","type":"electronic"}],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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History"}}],"article-number":"e70190"},{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:27:14Z","timestamp":1779290834636,"version":"3.51.4"},"reference-count":18,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"unspecified","delay-in-days":139,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","award":["ESR-23-22154"],"award-info":[{"award-number":["ESR-23-22154"]}],"id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Neurol Open"],"accepted":{"date-parts":[[2026,4,9]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Background<\/jats:title>\n Direct oral anticoagulants (rivaroxaban, apixaban, dabigatran) and warfarin treatment are associated with an increased risk of intracerebral haemorrhage (ICH). Specific reversal exists for warfarin (vitamin K\/prothrombin complex concentrate (PCC)) and dabigatran (idarucizumab). Data on protocol-guided non-specific 3-factor PCC for factor Xa inhibitor reversal are lacking.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n Our retrospective cohort study aimed to assess anticoagulation-related ICH secular trends. We also aimed to compare administration of reversal and antihypertensive treatments, where specific reversal agents were (dabigatran and warfarin) and were not (apixaban and rivaroxaban) available.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We included patients with anticoagulation-related non-traumatic ICH of <24\u2009hours duration from South Australian Stroke units (January 2017\u2013December 2023). Outcomes analysed included 30-day mortality and discharge modified Rankin Scale. Secondary outcomes included time to administration of reversal agent, intravenous antihypertensives and time to systolic blood pressure (BP) lowering <140\u2009mm Hg.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 310 included patients (median age 83 (76, 87)), 208 (67%) were in the factor Xa inhibitor group and 102 (33%) in the warfarin\/dabigatran group. The proportion of factor Xa inhibitor-associated ICH increased from 3.7% in 2017 to 19.8% in 2023 (p<0.0001). The warfarin\/dabigatran group was more likely to receive reversal (57% warfarin\/dabigatran vs factor Xa inhibitor 39%, p=0.005). Where administered, time from hospital arrival to reversal did not differ between groups (132\u2009min (94, 231) warfarin\/dabigatran vs factor Xa inhibitor 126 (60, 225); p=0.3), nor did time to first dose of intravenous antihypertensives, time to BP <140\u2009mm Hg and 30-day mortality.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Factor Xa inhibitor-related ICH increased proportionally over the study period. These patients were less likely to receive reversal treatment than warfarin\/dabigatran-related ICH. There was no difference between time to administration of PCC and time to antihypertensive metrics. The high mortality in our study underscores the need for effective optimised and timely treatments.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjno-2025-001239","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:35:25Z","timestamp":1779287725000},"page":"e001239","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Anticoagulation associated intracerebral haemorrhage trends, treatment and outcomes in a metropolitan cohort: analysed by availability of specific versus non-specific reversal agents"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5264-5885","authenticated-orcid":false,"given":"Shaddy","family":"El-Masri","sequence":"first","affiliation":[{"name":"Department of Neurology, Flinders Medical Centre, Bedford Park, South Australia, Australia"},{"name":"Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, 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South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Howson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Stretton","sequence":"additional","affiliation":[{"name":"Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia"},{"name":"The University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Zweck","sequence":"additional","affiliation":[{"name":"Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, 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Open"],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjno-2025-001239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:35:27Z","timestamp":1779287727000},"score":7.5584245,"resource":{"primary":{"URL":"https:\/\/neurologyopen.bmj.com\/lookup\/doi\/10.1136\/bmjno-2025-001239"}},"issued":{"date-parts":[[2026,1]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,5,20]]},"published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1136\/bmjno-2025-001239"],"URL":"https:\/\/doi.org\/10.1136\/bmjno-2025-001239","ISSN":["2632-6140"],"issn-type":[{"value":"2632-6140","type":"electronic"}],"published":{"date-parts":[[2026,1]]}},{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:44:22Z","timestamp":1782708262562,"version":"3.54.5"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian 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However, there is limited understanding of contrasting leaf cellular P\u2010allocation patterns and their physiological consequences. We quantified leaf P fractions, photosynthetic P\u2010use efficiency (PPUE), and P\u2010remobilisation efficiency (PRE) in five chickpea accessions exhibiting contrasting cellular P\u2010allocation patterns. Leaf lifespan and concentrations of key phytohormones were also measured, including abscisic acid (ABA), salicylic acid (SA) and jasmonates. Cellular P\u2010allocation patterns were more strongly associated with leaf lifespan than with PPUE or PRE. Accessions allocating a greater proportion of P to the mesophyll exhibited longer leaf lifespan, which was associated with lower jasmonate concentrations, rather than ABA. Surprisingly, greater P allocation to the epidermis was driven by a higher proportion of metabolite P. At the cellular level, we primarily observed a significant negative correlation between P and calcium concentrations in mesophyll cells, but not in the epidermis. Our findings provide the first evidence that leaf tissue\u2010specific P\u2010allocation patterns vary among chickpea accessions. Preferential allocation of P to photosynthetically active cells was associated with longer leaf lifespan. Differences in jasmonate concentrations accompanied these patterns. Collectively, these findings highlight new opportunities to enhance P\u2010use efficiency in crop breeding programs.<\/jats:p>","DOI":"10.1111\/pce.70704","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T03:56:38Z","timestamp":1782705398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Leaf Tissue\u2010Specific Phosphorus Allocation Is Linked to Leaf Lifespan in Chickpea Accessions"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8997-8763","authenticated-orcid":false,"given":"Xiaolong","family":"Feng","sequence":"first","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"The UWA Institute of Agriculture The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5188-4737","authenticated-orcid":false,"given":"Peta L.","family":"Clode","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"Centre for Microscopy, Characterisation and Analysis The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7139-2693","authenticated-orcid":false,"given":"Shuyan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"The UWA Institute of Agriculture The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5346-1711","authenticated-orcid":false,"given":"Shu Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8127-645X","authenticated-orcid":false,"given":"Jiayin","family":"Pang","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"The UWA Institute of Agriculture The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0983-8614","authenticated-orcid":false,"given":"Ga\u00e9tan","family":"Glauser","sequence":"additional","affiliation":[{"name":"Neuch\u00e2tel Platform of Analytical Chemistry University of Neuch\u00e2tel Neuch\u00e2tel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6097-4235","authenticated-orcid":false,"given":"Kadambot H. 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The Hybrid Convergent procedure, combining initial surgical AF ablation with a concurrent or staged endocardial catheter-based component, offers a potential solution for refractory cases. While effective as a de novo treatment for persistent AF, outcomes of this procedure in patients who failed prior catheter ablation remains uncertain. Our aim was to evaluate its efficacy and safety in this patient group.\n <\/jats:p>\n \n Methods:<\/jats:bold>\n We conducted a single-center retrospective cohort study involving consecutive patients selected for the Hybrid Convergent procedure between May 2019 and October 2022 at a single center in Perth, Western Australia. Eligible patients had symptomatic AF and failed prior catheter ablation and antiarrhythmic drugs. The primary outcome was single procedure freedom from atrial arrhythmias, on or off antiarrhythmic drugs at 12 months. Overall follow-up freedom from AF, 12-month AF burden, complications and reinterventions were also recorded.\n <\/jats:p>\n \n Results:<\/jats:bold>\n Sixty-two patients underwent both stages of the Hybrid Convergent procedure. All received concomitant thoracoscopic left atrial appendage exclusion. Of these, 46 (74.2%) were male, 27 (45.3%) had paroxysmal AF, and 15 (24.2%) had implantable loop recorders (ILRs). The mean duration since AF diagnosis was 9.5\u00b17.1 years, with a median of 3 prior catheter ablations for AF. The median follow-up was 25.9 (13-48) months. After 12 months, 36 (62.9%) patients remained free from any atrial arrhythmia (figure 1). At this time point, 47 (75.8%) patients had an atrial arrhythmia burden of less than 5%. For the overall follow-up period, 32 (51.6%) patients maintained freedom from any atrial arrhythmia. Among patients with ILRs, the 12 month atrial arrhythmia free survival was 36.6%, compared with 64.4% in those without ILRs. Nine patients required repeat catheter ablation. There was one major complication.\n <\/jats:p>\n \n Conclusions:<\/jats:bold>\n Our initial experience with the Hybrid Convergent procedure demonstrates sustained effectiveness and safety for patients with paroxysmal or persistent AF who have previously failed catheter ablation strategies.\n <\/jats:p>\n \n \n <\/jats:p>","DOI":"10.1161\/circ.150.suppl_1.4138840","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T06:27:23Z","timestamp":1731565643000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 4138840: Hybrid Convergent Procedure as a \u2018Bail Out\u2019 Strategy In Patients with Atrial Fibrillation Resistant To Catheter Ablation"],"prefix":"10.1161","volume":"150","author":[{"given":"Remy","family":"Spring","sequence":"first","affiliation":[{"name":"Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Playford","sequence":"additional","affiliation":[{"name":"University of Tasmania, Hobart, Tasmania, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Eranki","sequence":"additional","affiliation":[{"name":"St Georges Hospital, Sydney, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pragnesh","family":"Joshi","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Playford","sequence":"additional","affiliation":[{"name":"University of Notredame, Fremantle, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rukshen","family":"Weerasooriya","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation"],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1161\/circ.150.suppl_1.4138840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T14:01:35Z","timestamp":1750946495000},"score":7.558378,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/circ.150.suppl_1.4138840"}},"issued":{"date-parts":[[2024,11,12]]},"references-count":0,"journal-issue":{"issue":"Suppl_1","published-print":{"date-parts":[[2024,11,12]]}},"alternative-id":["10.1161\/circ.150.suppl_1.4138840"],"URL":"https:\/\/doi.org\/10.1161\/circ.150.suppl_1.4138840","ISSN":["0009-7322","1524-4539"],"issn-type":[{"type":"print","value":"0009-7322"},{"type":"electronic","value":"1524-4539"}],"published":{"date-parts":[[2024,11,12]]},"assertion":[{"value":"2024-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:09:35Z","timestamp":1779250175647,"version":"3.51.4"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Community &amp; Applied Soc Psy"],"published-print":{"date-parts":[[2024,7]]},"abstract":"Abstract<\/jats:title>\n Australia Day continues to be a divisive event in Australia. The contentious public holiday currently falls on January 26, a date which marks the beginning of colonisation in Australia and the subsequent persecution of Australian First Nations peoples. Despite the date's controversial historical ties, some Australians remain in support of \u2018saving the date\u2019. The current study aimed to deepen understanding of Australians' thoughts and opinions regarding Australia Day, including their reasons in support of changing or saving the January 26 date. Responses from 208 Australian citizens, collected via a national survey, were thematically examined. While analysis confirmed a division in attitudes towards Australia Day, greater support for date change was found among younger Australians. The current study applies and extends Social Identity Theory, identifying key themes which were linked to support for date change and improved intergroup relations within the Australia Day context. Themes included acknowledgement of colonisation and the damage done to First Nations peoples, participants' political views, and educational awareness. These findings have important theoretical and practical implications which may assist with breaking down the social barriers that support date\u2010change resistance, helping Australians move towards a more inclusive future.<\/jats:p>","DOI":"10.1002\/casp.2847","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T12:37:23Z","timestamp":1720528643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A nation divided: A qualitative exploration of\n Australians<\/scp>\n ' attitudes towards the date of\n Australia Day<\/scp>"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8506-8571","authenticated-orcid":false,"given":"Alice","family":"Boorman","sequence":"first","affiliation":[{"name":"Justice and Society University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Webb","sequence":"additional","affiliation":[{"name":"Justice and Society University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Potter","sequence":"additional","affiliation":[{"name":"Justice and Society University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-6504","authenticated-orcid":false,"given":"Eliza","family":"Mortimer\u2010Royle","sequence":"additional","affiliation":[{"name":"Justice and Society University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Abbatangelo B.(2024 March 6).Regenerating in the wake of the referendum. Retrieved fromhttps:\/\/indigenousx.com.au\/regenerating-after-the-referendum\/"},{"key":"e_1_2_11_3_1","unstructured":"Aboriginal Heritage Office. (n.d.).Clans of Sydney. Retrieved fromhttps:\/\/www.aboriginalheritage.org\/history\/clans-of-sydney\/"},{"key":"e_1_2_11_4_1","unstructured":"Australian Bureau of Statistics. (2023).National state and territory population. Retrieved fromhttps:\/\/www.abs.gov.au\/statistics\/people\/population\/national-state-and-territory-population\/latest-release"},{"key":"e_1_2_11_5_1","unstructured":"Australian Curriculum. (n.d.).Aboriginal and Torres Strait Islander histories and cultures. Retrieved fromhttps:\/\/www.australiancurriculum.edu.au\/f-10-curriculum\/cross-curriculum-priorities\/aboriginal-and-torres-strait-islander-histories-and-cultures\/"},{"key":"e_1_2_11_6_1","unstructured":"Australian Institute of Aboriginal and Torres Strait Islander Studies. (2023 January 20).The 1938 day of mourning. Retrieved fromhttps:\/\/aiatsis.gov.au\/explore\/day-of-mourning"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-2052-3"},{"key":"e_1_2_11_8_1","unstructured":"Biddle N. Gray M. McAllister A. &Qvortrup M.(2023 November 28).Detailed analysis of the 2023 Voice to Parliament Referendum and related social and political attitudes. Centre for Social Research and Methods. Retrieved fromhttps:\/\/apo.org.au\/node\/325112"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1368430220942567"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/2159676X.2019.1628806"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/14407833211044548"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jasp.12527"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11135-021-01182-y"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049732318788379"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2023.104439"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/08111146.2019.1631786"},{"key":"e_1_2_11_18_1","first-page":"1","article-title":"\u201cChange the date to May 8, maaate\u201d: Past and present analysis of a controversial national day as Australia \u2018celebrates\u2019 the 230th anniversary of the First Fleet's arrival","volume":"22","author":"Delphine D.","year":"2019","journal-title":"Cultures of the Commonwealth"},{"key":"e_1_2_11_19_1","unstructured":"Department of the Prime Minister and Cabinet. (2022).Australian flags. Retrieved fromhttps:\/\/www.pmc.gov.au\/sites\/default\/files\/resource\/download\/australia-flag-booklet-fa-accessible-150dpi.pdf"},{"key":"e_1_2_11_20_1","unstructured":"Encyclopaedia Britannica. (n.d.).Australia Day. Retrieved August 24 2023 fromhttps:\/\/www.britannica.com\/topic\/Australia-Day"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/casp.2381"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1559-1816.2000.tb02464.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1440783314524846"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.5204\/mcj.2761"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-014-0533-4"},{"key":"e_1_2_11_26_1","first-page":"23","article-title":"The impact of social media on history education: A view from England","volume":"17","author":"Haydn T.","year":"2017","journal-title":"Yesterday and Today"},{"key":"e_1_2_11_27_1","unstructured":"Heiss A. &Gibson M.(n.d.).Aboriginal people and place. Retrieved fromhttps:\/\/www.sydneybarani.com.au\/sites\/aboriginal-people-and-place\/"},{"key":"e_1_2_11_28_1","unstructured":"Institute of Public Affairs. (2023 January 23).Australia Day Poll. Retrieved fromhttps:\/\/ipa.org.au\/wp-content\/uploads\/2023\/01\/IPA-Poll-Australia-Day-2023.pdf"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/10361146.2021.2012125"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/0142159X.2020.1755030"},{"key":"e_1_2_11_31_1","unstructured":"Korff J.(2023 February 10).Australia Day\u2014Invasion Day. Retrieved fromhttps:\/\/www.creativespirits.info\/aboriginalculture\/history\/australia-day-invasion-day"},{"key":"e_1_2_11_32_1","unstructured":"Latimore J.(2018 January 25).It's convenient to say Aboriginal people support Australia Day. But it's not true. Retrieved fromhttps:\/\/indigenousx.com.au\/jack-latimore-its-convenient-to-say-aboriginal-people-support-australia-day-but-its-not-true\/"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.5964\/jspp.8125"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/casp.2444"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/20597991211006288"},{"key":"e_1_2_11_36_1","unstructured":"Lumivero. (2023).NVivo(Version 14). [Computer software]. Retrieved fromhttps:\/\/lumivero.com\/products\/nvivo\/"},{"key":"e_1_2_11_37_1","doi-asserted-by":"crossref","unstructured":"Maguire A.(2023 October 15).Explainer: Australia has voted against an Indigenous Voice to Parliament. Here's what happened. Retrieved fromhttps:\/\/theconversation.com\/explainer-australia-has-voted-against-an-indigenous-voice-to-parliament-heres-what-happened-215155","DOI":"10.64628\/AA.k5dvnvgfq"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.4337\/9781789904345.00022"},{"key":"e_1_2_11_39_1","unstructured":"McIlroy T.(2023 January 26).No change to Australia Day date: Albanese.The Australian Financial Review. Retrieved fromhttps:\/\/www.afr.com\/politics\/federal\/no-change-to-australia-day-date-albanese-20230126-p5cfna"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/104973299129121622"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/104973200129118183"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/asap.12399"},{"key":"e_1_2_11_43_1","unstructured":"National Australia Day Council. (2023 January 26).Australia Day. Retrieved fromhttps:\/\/cms.australiaday.org.au\/about"},{"key":"e_1_2_11_44_1","unstructured":"New South Wales Aboriginal Land Council. (2023 October 14).A statement from Indigenous Australians who supported the Voice referendum. Retrieved fromhttps:\/\/alc.org.au\/newsroom\/media-releases\/a-statement-from-indigenous-australians-who-supported-the-voice-referendum\/"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1609406917733847"},{"key":"e_1_2_11_46_1","unstructured":"Pennay D. &Bongiorno F.(2019 January 25).Barbeques and black armbands: Australians' attitudes to Australia Day. Social Research Centre. Retrieved fromhttps:\/\/srcentre.com.au\/bbqsandblackarmbands"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/15586898221126816"},{"key":"e_1_2_11_48_1","unstructured":"Reconciliation Australia. (2018).Let's talk\u2026January 26. Retrieved fromhttps:\/\/www.reconciliation.org.au\/wp-content\/uploads\/2021\/10\/Lets-Talk\u2026January-26.pdf"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/0312407X.2015.1024264"},{"key":"e_1_2_11_50_1","unstructured":"Roy Morgan. (2023 January 24).Nearly two\u2010thirds of Australians (64%) say January 26 should be known as \u2018Australia day\u2019 virtually unchanged on a year ago. Retrieved fromhttps:\/\/www.roymorgan.com\/findings\/9162-roy-morgan-survey-australia-day-january-24-2023"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/pops.12818"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjso.12418"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/1440783320934184"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/13688790.2019.1655184"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ps.33.020182.000245"},{"key":"e_1_2_11_56_1","first-page":"33","volume-title":"The social psychology of intergroup relations","author":"Tajfel H.","year":"1979"},{"key":"e_1_2_11_57_1","doi-asserted-by":"crossref","unstructured":"Watego C.(2015 January 26).The day I don't feel Australian? That would be Australia Day. Retrieved fromhttps:\/\/theconversation.com\/the-day-i-dont-feel-australian-that-would-be-australia-day-36352","DOI":"10.64628\/AA.xf43gnpyq"},{"issue":"3","key":"e_1_2_11_58_1","first-page":"81","article-title":"National identity attachment and its variables","volume":"22","author":"Windari T.","year":"2021","journal-title":"Journal of International Women's Studies"},{"key":"e_1_2_11_59_1","unstructured":"Wyld K.(2018 January 21).What kind of morality do they want us to celebrate on that day. Retrieved fromhttps:\/\/indigenousx.com.au\/karen-wyld-what-kind-of-morality-do-they-want-us-to-celebrate-on-that-day\/"}],"container-title":["Journal of Community & Applied Social Psychology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/casp.2847","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/casp.2847","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/casp.2847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:34:29Z","timestamp":1779248069000},"score":7.558378,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/casp.2847"}},"issued":{"date-parts":[[2024,7]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/casp.2847"],"URL":"https:\/\/doi.org\/10.1002\/casp.2847","archive":["Portico"],"ISSN":["1052-9284","1099-1298"],"issn-type":[{"value":"1052-9284","type":"print"},{"value":"1099-1298","type":"electronic"}],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2847"},{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T01:54:41Z","timestamp":1760320481585,"version":"3.41.2"},"reference-count":11,"publisher":"SPE","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2024,10,11]]},"abstract":"Abstract<\/jats:title>\n Surveillance data was acquired in four Gorgon CO2 injection wells using Distributed Temperature Sensing (DTS) and Distributed Acoustic Sensing (DAS) technology. The primary objective was to acquire temperature warmback data to quantify the CO2 injection profile and demonstrate containment at the wellbores. The secondary objective was to demonstrate the application of fibre optics in subsurface monitoring for the CO2 injection project by acquiring multi-offset Vertical Seismic Profile (VSP) surveys and continuous DAS data.<\/jats:p>\n Temperature warmback surveys were recorded over 3-5 days following a 24-hour injection period to cool the formation. Coincident multi-offset VSP surveys were acquired during the warmback period using a vibroseis truck. A disposable fibre optic technology was selected for these surveys due to its lightweight equipment and small footprint, reducing intervention risk over live CO2 wells. Bare optical fibres are wound within a probe that free falls into the well, unspooling two fibres as it descends. Developed work practices considered safe wellhead access, avoiding phase changes to the CO2, effective pressure control and material selection.<\/jats:p>\n The four well program was completed without safety incident or major non-productive time. The probe was deployed to depth in all wells with no observed fibre degradation due to exposure to well fluids. The operator, disposable fibre and seismic survey providers collaborated efficiently to acquire data simultaneously. The acquisition was monitored on site and real-time streamed to decision support centers in Aberdeen and Houston.<\/jats:p>\n The warmback surveys were successful in demonstrating that CO2 is contained at the injection intervals; however, challenges were experienced acquiring complete and accurate temperature data across the injection intervals over the extended survey periods. The primary cause was fibre damage and\/or breakage due to crossflow between perforated sections. While a qualitative interpretation of the injection profile was possible for most wells, the combination of crossflow and Joules-Thomson cooling combined with fibre damage made quantification difficult. The nature, causes, management, and impact of these are discussed in the paper, along with lessons learned and potential mitigations.<\/jats:p>","DOI":"10.2118\/221097-ms","type":"proceedings-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:01:36Z","timestamp":1728604896000},"source":"Crossref","is-referenced-by-count":1,"title":["Disposable Fibre Optic Reservoir Monitoring Surveys in CO2 Injection Wells: Operations Planning, Outcomes and Lessons Learnt"],"prefix":"10.2118","author":[{"given":"T.","family":"Shawcross","sequence":"additional","affiliation":[{"name":"Chevron Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Well-SENSE, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Green","sequence":"additional","affiliation":[{"name":"Well-SENSE, Aberdeen, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Yurikov","sequence":"additional","affiliation":[{"name":"Chevron Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Chevron Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Phythian","sequence":"additional","affiliation":[{"name":"Chevron Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Scoby-Smith","sequence":"additional","affiliation":[{"name":"Chevron Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Jain","sequence":"additional","affiliation":[{"name":"Chevron Technology Company, Houston, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"861","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"2024101100005649800_R1","doi-asserted-by":"crossref","unstructured":"Chen, D., Huang, K., Meng, X., Liu, J., Zhang, B., Sun, T., Shen, J.Wei, J., Wu, H., Teng, Q. (2021). Real-Time Down-Hole Monitoring of Gas Injection Profile Using Fibre-Optic Distribute Temperature and Acoustic Sensing in Tarim. Paper presented at IPTC, virtual, 23 March \u2013 1 April, IPTC-21177-MShttps:\/\/doi.org\/10.2523\/IPTC-21177-MS","DOI":"10.2523\/IPTC-21177-MS"},{"key":"2024101100005649800_R2","doi-asserted-by":"crossref","unstructured":"Crawford, R., Green, A., LynchP., Feherty, C. (2023). Disposable Fibre Optic Surveys Optimise Wells and Reduce CO2 Emissions in Unconventional Assets. Paper presented at SPE Asia Pacific Unconventional Resources Symposium, Brisbane, Australia, 14-15 November, SPE-217339-MShttps:\/\/doi.org\/10.2118\/217339-MS","DOI":"10.2118\/217339-MS"},{"key":"2024101100005649800_R3","doi-asserted-by":"crossref","unstructured":"Green, A.\n (2021). Game-Changing Technology for Low Cost, High Quality Borehole Seismic Data Acquisition. Paper presented at the 82 EAGE Annual Conference & Exhibition, Amsterdam, The NetherlandsOctober 18\u201321. https:\/\/doi.org\/10.3997\/2214-4609.202113047.","DOI":"10.3997\/2214-4609.202113047"},{"key":"2024101100005649800_R4","doi-asserted-by":"crossref","DOI":"10.1201\/9781315119014","article-title":"An Introduction to Distributed Optical Fibre Sensors","author":"Hartog","year":"2017"},{"key":"2024101100005649800_R5","doi-asserted-by":"crossref","unstructured":"Hashish\n R. G.\n , Zeidouni, M. (2019). Analytical approach for injection profiling through warm-back analysis in multilayer reservoirs. Paper presented at SPE\/AAPG\/SEG Unconventional Resources Technology Conference, Denver, USA, 22-24 July, SPE-197042-PA. https:\/\/doi.org\/10.15530\/urtec-2019-61","DOI":"10.15530\/urtec-2019-61"},{"key":"2024101100005649800_R6","doi-asserted-by":"crossref","DOI":"10.1016\/j.advwatres.2022.104203","article-title":"CO2 Zonal Injection Rate Allocation and Plume Extent Evaluation Through Well Temperature Analysis","volume":"164","author":"Hashish","year":"2022","journal-title":"Advances in Water Resources"},{"key":"2024101100005649800_R7","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7073619","article-title":"Identifying and Correcting Step Losses in Single-Ended Fiber-Optic Distributed Temperature Sensing Data","author":"Hausner","year":"2016","journal-title":"Journal of Sensors"},{"key":"2024101100005649800_R8","doi-asserted-by":"crossref","unstructured":"Higginson, P., Purkis, D., Webster, M. (2017). Advancing the Application of Downhole Fibre Optics with a Novel Low Cost Disposable Deployment Method. Paper presented at the SPE Offshore Europe Conference & Exhibition, Aberdeen, United Kingdom, September 5-8, SPE-186124-MShttps:\/\/doi.org\/10.2118\/186124-MS.","DOI":"10.2118\/186124-MS"},{"key":"2024101100005649800_R9","doi-asserted-by":"crossref","unstructured":"Karaman, O.S., Kutlik, R.L., Kluth, E.L. (1996). A Field Period to Test Fiber Optic Sensors for Downhole Temperature and Pressure Measurements, West Coalinga Field, California. Paper SPE 35685 presented at the SPE Western Regional Meeting, Anchorage, Alaska, May 22-24","DOI":"10.2523\/35685-MS"},{"key":"2024101100005649800_R10","first-page":"277","article-title":"Distributed and multiplexed fibre optic sensors","author":"Kersey","year":"2011"},{"key":"2024101100005649800_R11","doi-asserted-by":"crossref","DOI":"10.1190\/tle43080515.1","article-title":"Offset VSP Acquired with a Single-Use Fibre Optic Probe: Gorgon CCS Case Study","author":"Tertyshnikov","year":"2024","journal-title":"The Leading Edge"}],"event":{"name":"APOGCE 2024","start":{"date-parts":[[2024,10,15]]},"location":"Perth, Australia","end":{"date-parts":[[2024,10,17]]},"acronym":"24APOG"},"container-title":["APOGCE 2024"],"link":[{"URL":"https:\/\/onepetro.org\/SPEAPOG\/proceedings-pdf\/doi\/10.2118\/221097-MS\/3675031\/spe-221097-ms.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onepetro.org\/SPEAPOG\/proceedings-pdf\/doi\/10.2118\/221097-MS\/3675031\/spe-221097-ms.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:01:41Z","timestamp":1728604901000},"score":7.5583563,"resource":{"primary":{"URL":"https:\/\/onepetro.org\/SPEAPOG\/proceedings\/24APOG\/24APOG\/D021S008R001\/570379"}},"issued":{"date-parts":[[2024,10,11]]},"references-count":11,"URL":"https:\/\/doi.org\/10.2118\/221097-ms","published":{"date-parts":[[2024,10,11]]},"article-number":"D021S008R001"},{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:20:22Z","timestamp":1698124822012},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2023,10,23]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Swallowing is a complex activity associated with cortical arousal and tachycardia in sleep(1). Obstructive sleep apnoea (OSA) has been associated with dysfunction and altered biomechanics of swallow (2-3). This study seeks to investigate patterns of swallow frequency and associated tachycardia in relation to OSA severity.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Anthropometric and polysomnographic data for 70 subjects were analysed. Swallow index (SI; swallows per hour) and average heart rate changes from 30 seconds pre- to 10 seconds post-swallow were derived from epiglottic pressure and electrocardiogram signals respectively. This study had approval from the local district ethics committee.<\/jats:p>\n <\/jats:sec>\n \n Progress to date<\/jats:title>\n Analysis has been completed for 34 subjects (median age 47.5, range 24-64; 24 males), most with at least moderate OSA (n=20\/26). Mean SI was 3.2 in subjects without OSA (n=2), 8 in mild OSA (n=4), 5.8 in moderate OSA (n=10) and 9 in severe OSA (n=10). Mean swallow-related tachycardia was 24.3bpm in subjects without OSA, compared to 14.0bpm in those with severe OSA. Mean swallow-related tachycardia increased with progressive sleep stages (14.8bpm in wakefulness; 16.8bpm Stage 1; 16.8bpm Stage 2; 19.0bpm Stage 3; 19.4bpm in REM). A negative correlation was observed between sleep SI and magnitude of associated tachycardia (Pearson correlation r=-0.387, p=0.026).<\/jats:p>\n <\/jats:sec>\n \n Intended outcome and impact<\/jats:title>\n Our results support existing observations that swallow-associated tachycardia is reliably conserved in sleep, and suggest possible new relationships between swallow frequency and associated tachycardia with OSA severity and sleep stage. We intend with further dataset analyses to explore relationships between sleep swallow physiology and OSA pathophysiology.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/sleepadvances\/zpad035.027","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:45:54Z","timestamp":1698068754000},"page":"A9-A10","source":"Crossref","is-referenced-by-count":0,"title":["O027 Patterns of nocturnal swallow frequency and related tachycardia with sleep stages and obstructive sleep apnoea severity"],"prefix":"10.1093","volume":"4","author":[{"given":"A","family":"Lin","sequence":"first","affiliation":[{"name":"Neuroscience Research Australia , Randwick , Australia"},{"name":"Prince Of Wales Hospital , Randwick , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Bull","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia , Randwick , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Burke","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia , Randwick , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Lewis","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia , Randwick , Australia"},{"name":"Prince Of Wales Hospital , Randwick , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Bilston","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia , Randwick , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,23]]},"container-title":["Sleep Advances"],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/sleepadvances\/article-pdf\/4\/Supplement_1\/A9\/52405534\/zpad035.027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/sleepadvances\/article-pdf\/4\/Supplement_1\/A9\/52405534\/zpad035.027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:45:55Z","timestamp":1698068755000},"score":7.5583353,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleepadvances\/article\/4\/Supplement_1\/A9\/7326882"}},"issued":{"date-parts":[[2023,10,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2023,10,23]]}},"URL":"https:\/\/doi.org\/10.1093\/sleepadvances\/zpad035.027","ISSN":["2632-5012"],"issn-type":[{"value":"2632-5012","type":"electronic"}],"published-other":{"date-parts":[[2023,10,1]]},"published":{"date-parts":[[2023,10,1]]}},{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:21:43Z","timestamp":1788956503683,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,8]],"date-time":"2024-12-08T00:00:00Z","timestamp":1733616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,12,8]],"date-time":"2024-12-08T00:00:00Z","timestamp":1733616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP200100762"],"award-info":[{"award-number":["DP200100762"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP210100296"],"award-info":[{"award-number":["DP210100296"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsess.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Plant Genome"],"published-print":{"date-parts":[[2025,3]]},"abstract":"Abstract<\/jats:title>\n \n Brassicas<\/jats:italic>\n are an economically important crop species that provide a source of healthy oil and vegetables. With the rising population and the impact of climate change on agriculture, there is an increasing need to improve agronomically important traits of crops such as\n Brassica<\/jats:italic>\n . The genomes of plant species have significant sequence presence absence variation (PAV), which is a source of genetic variation that can be used for crop improvement, and this species variation can be captured through the construction of pangenomes. Graph pangenomes are a recent reference format that represent the genomic variation with a species or population as alternate paths in a sequence graph. Graph pangenomes contain information on alignment, PAV, and annotation. Here we present the first multi\u2010species graph pangenome for\n Brassica<\/jats:italic>\n visualized with pangenome analyzer with chromosomal exploration (Panache).\n <\/jats:p>","DOI":"10.1002\/tpg2.20535","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T02:35:12Z","timestamp":1733711712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Brassica<\/i>\n Panache: A multi\u2010species graph pangenome representing presence absence variation across forty\u2010one\n Brassica<\/i>\n genomes"],"prefix":"10.1002","volume":"18","author":[{"given":"Tessa R.","family":"MacNish","sequence":"first","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"Center for Applied Bioinformatics The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hawlader A.","family":"Al\u2010Mamun","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"Center for Applied Bioinformatics The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8530-3067","authenticated-orcid":false,"given":"Philipp E.","family":"Bayer","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"Center for Applied Bioinformatics The University of Western Australia Perth Western Australia Australia"},{"name":"Minderoo Foundation Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"McPhan","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"Center for Applied Bioinformatics The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandria G. Tay","family":"Fernandez","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"Center for Applied Bioinformatics The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shriprabha R.","family":"Upadhyaya","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"Center for Applied Bioinformatics The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Oil Crops Research Institute, CAAS Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5391-5824","authenticated-orcid":false,"given":"Jacqueline","family":"Batley","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5807-9466","authenticated-orcid":false,"given":"Isobel A. P.","family":"Parkin","sequence":"additional","affiliation":[{"name":"Agriculture and Agri\u2010Food Canada Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Global Institute for Food Security Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7599-6760","authenticated-orcid":false,"given":"David","family":"Edwards","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"Center for Applied Bioinformatics The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072590"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2019.12.006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41477\u2010020\u20100733\u20100"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.12742"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tpg2.20112"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/tpg2.20221"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.13674"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tpg2.20109"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41477\u2010018\u20100289\u20104"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz597"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00122\u2010020\u201003664\u20103"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010021\u201002383\u20102"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253435"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010023\u201002914\u2010z"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab688"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010022\u201001099\u20108"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010genom\u2010120219\u2010080406"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1921046117"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.15885"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4227"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.12499"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13390"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac308"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915\u2010021\u201001031\u20102"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xplc.2023.100791"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41477\u2010021\u201000928\u20108"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u201012\u2010491"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evae081"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.agrcom.2024.100039"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.12867"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn564"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2019.10.012"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010020\u201002168\u2010z"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.13522"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102164\u201015\u2010250"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010024\u201010302\u20105"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4930"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.023"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201069389\u2010x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.13515"},{"key":"e_1_2_9_42_1","first-page":"389","article-title":"Genome analysis in Brassica with special reference to the experimental formation of B. napus and peculiar mode of fertilization","volume":"7","author":"Nagaharu U.","year":"1935","journal-title":"The Journal of Japanese Botany"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xplc.2023.100725"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11151949"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq033"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad987"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066428"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/tpg2.20100"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giaa137"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.666342"},{"key":"e_1_2_9_51_1","unstructured":"Smit A. F. A. Hubley R. &Green P.(2013\u20132015).RepeatMasker 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Plant Genome"],"language":"en","link":[{"URL":"https:\/\/acsess.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tpg2.20535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsess.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/tpg2.20535","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsess.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tpg2.20535","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/acsess.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tpg2.20535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:44:28Z","timestamp":1775803468000},"score":7.558262,"resource":{"primary":{"URL":"https:\/\/acsess.onlinelibrary.wiley.com\/doi\/10.1002\/tpg2.20535"}},"issued":{"date-parts":[[2024,12,8]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/tpg2.20535"],"URL":"https:\/\/doi.org\/10.1002\/tpg2.20535","archive":["Portico"],"ISSN":["1940-3372","1940-3372"],"issn-type":[{"value":"1940-3372","type":"print"},{"value":"1940-3372","type":"electronic"}],"published":{"date-parts":[[2024,12,8]]},"assertion":[{"value":"2024-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001798","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001799","name":"Murdoch University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001799","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001063","name":"Raine Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023759","name":"Telethon Kids Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023759","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001069","name":"Women and Infants Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n Investigating the impact of early childhood ventilation tube insertion (VTI) on long\u2010term language outcomes.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Longitudinal cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n A total of 2900 pregnant women participated in the Raine Study between 1989 and 1991 in Western Australia, and 2868 children have been followed up.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Based on parental reports, 314 children had a history of recurrent otitis media but did not undergo VTI (rOM group); another 94 received VTI (VTI group); while 1735 had no history of rOM (reference group) in the first 3\u2009years of childhood. Children with data on outcomes and confounders were included in analyses of PPVT\u2010R at ages 6 (\n n<\/jats:italic>\n \u2009=\u20091567) and 10\u2009years (\n n<\/jats:italic>\n \u2009=\u20091313) and CELF\u2010III at 10\u2009years (\n n<\/jats:italic>\n \u2009=\u20091410) (approximately 5% in the VTI group and 15% in the rOM group).\n <\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n Peabody Picture Vocabulary Test\u2010Revised edition and Clinical Evaluation of Language Fundamentals\u00ae Preschool\u20103.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At 6\u2009years, mean PPVT\u2010R scores were significantly lower in the VTI group than the reference group (\u03b2\u2009=\u2009\u22123.3; 95% CI [\u22126.5 to \u22120.04],\n p<\/jats:italic>\n \u2009=\u2009.047). At 10\u2009years, while the difference between the VTI and reference groups was less pronounced for PPVT\u2010R scores, there was a small but consistent trend of lower measures, on average, across CELF\u2010III scores (expressive: \u03b2\u2009=\u2009\u22123.4 [\u22127.1 to 0.27],\n p<\/jats:italic>\n \u2009=\u2009.069; receptive: \u03b2\u2009=\u2009\u22124.1 [\u22127.9 to \u22120.34],\n p<\/jats:italic>\n \u2009=\u2009.033; total: \u03b2\u2009=\u2009\u22123.9 [\u22127.5 to \u22120.21],\n p<\/jats:italic>\n \u2009=\u2009.038). There was no evidence to suggest that language outcomes in the rOM group differed from the reference group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Lower scores of language outcomes in school\u2010aged children who received VTI in early childhood may suggest a long\u2010term risk which should be considered alongside the potential benefits of VTI.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/coa.14121","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T18:58:41Z","timestamp":1699556321000},"page":"191-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of ventilation tube insertion on long\u2010term language outcomes at 6 and 10\u2009years of age: A prospective pregnancy cohort study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7248-2908","authenticated-orcid":false,"given":"Eman M. A.","family":"Alenezi","sequence":"first","affiliation":[{"name":"Faculty of Allied Health Sciences Kuwait University Kuwait City Kuwait"},{"name":"The University of Western Australia Nedlands Western Australia Australia"},{"name":"Telethon Kids Institute The University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8834-6089","authenticated-orcid":false,"given":"Monique","family":"Robinson","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth J.","family":"McKinnon","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6064-5837","authenticated-orcid":false,"given":"Samuel D.","family":"Calder","sequence":"additional","affiliation":[{"name":"College of Health and Medicine University of Tasmania nipaluna\/Hobart, Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2899-4321","authenticated-orcid":false,"given":"Tamara","family":"Veselinovi\u0107","sequence":"additional","affiliation":[{"name":"The University of Western Australia Nedlands Western Australia Australia"},{"name":"Telethon Kids Institute The University of Western Australia Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7562-7228","authenticated-orcid":false,"given":"Peter C.","family":"Richmond","sequence":"additional","affiliation":[{"name":"The University of Western Australia Nedlands Western Australia Australia"},{"name":"Telethon Kids Institute The University of Western Australia Nedlands Western Australia Australia"},{"name":"Perth Children's Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2911-5381","authenticated-orcid":false,"given":"Robert H.","family":"Eikelboom","sequence":"additional","affiliation":[{"name":"School of Allied Health, Faculty of Health Sciences Curtin University Perth Western Australia Australia"},{"name":"Ear Science Institute Australia Subiaco Western Australia Australia"},{"name":"Ear Sciences Centre The University of Western Australia Nedlands Western Australia Australia"},{"name":"Department of Speech Language Pathology and Audiology University of Pretoria Pretoria South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7216-8097","authenticated-orcid":false,"given":"Christopher G.","family":"Brennan\u2010Jones","sequence":"additional","affiliation":[{"name":"The University of Western Australia Nedlands Western Australia Australia"},{"name":"Telethon Kids Institute The University of Western Australia Nedlands Western Australia Australia"},{"name":"Perth Children's Hospital Perth Western Australia Australia"},{"name":"School of Allied Health, Faculty of Health Sciences Curtin University Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.5.823"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.4.696"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.3.e238"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2009\/08-0250)"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1993.tb00838.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.3.685"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1044\/2020_JSLHR-19-00005"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-310729"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894021110S304"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812468849"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1044\/jslhr.4301.100"},{"issue":"10","key":"e_1_2_12_13_1","article-title":"Grommets (ventilation tubes) for hearing loss associated with otitis media with effusion in children","author":"Browning GG","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1991.tb01960.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05295-7"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2010.10.032"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.2.265"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050406"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062980"},{"issue":"5","key":"e_1_2_12_20_1","first-page":"1384","article-title":"Cohort profile: the Western Australian pregnancy cohort (Raine) study\u2010generation 2","volume":"46","author":"Straker L","year":"2017","journal-title":"Int J Epidemiol"},{"key":"e_1_2_12_21_1","volume-title":"Peabody picture vocabulary test, revised","author":"Dunn LM","year":"1981"},{"key":"e_1_2_12_22_1","volume-title":"The clinical evaluation of Langugae Fundamnetals","author":"Semel E","year":"1995"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12741"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.3.e42"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411300604"}],"container-title":["Clinical Otolaryngology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.14121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T01:39:02Z","timestamp":1707961142000},"score":7.558139,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.14121"}},"issued":{"date-parts":[[2023,11,9]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/coa.14121"],"URL":"https:\/\/doi.org\/10.1111\/coa.14121","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.14121\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14121\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14121\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14121\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.14121\/v2\/response1","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"published":{"date-parts":[[2023,11,9]]},"assertion":[{"value":"2022-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:30:29Z","timestamp":1782531029934,"version":"3.54.5"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2019,6,1]]},"abstract":"Diabetes increases the risk of premature death and reduces work productivity. We estimated the impact of diabetes in China in terms of mortality, years of life lost, and productivity-adjusted life years (PALYs) lost in the Chinese population. Life table modelling was used with simulated follow-up of those with diabetes in the Chinese population of working age (20-49 years in women and 20-59 years in men) until retirement age (50 years for women and 60 years for men). Data regarding the prevalence of diabetes, as well as excess mortality, labor force drop out and productivity loss attributable to diabetes, were taken from published sources. Models were constructed for the cohort with diabetes and repeated for the same cohort assuming that they had no diabetes. The differences in number of deaths, years of life lived and PALYs lived between the two models reflected the impact of diabetes. The World Health Organization standard 3% annual discount rate was applied to years of life and PALYs lived. In 2017, an estimated 56.4 million people of working age in China (7.1%) had diabetes. With simulated follow-up, those with diabetes were predicted to experience an estimated 4.1 million more deaths, the loss of 22.7 million years of life (3.7%) and the loss of 75.8 million PALYs (15.3%). This was equivalent to an average of 1.4 PALYs lost per person with diabetes. Based on gross domestic product (GDP) per full time worker in 2017, the loss in PALYs equated to a total of CNY \u00a517.4 trillion (USD $2.6 trillion) in lost GDP due to reduced productivity, with an average of \u00a5307,923 ($45,959) lost per person with diabetes. Our study demonstrates the significant cumulative impact of diabetes on productivity across the working lifetime in the Chinese population, highlighting the potential economic payoff of diabetes prevention in the longer term.<\/jats:p>\n \n Disclosure<\/jats:title>\n T.R. Hird: None. E. Zomer: Consultant; Self; Amgen Inc., AstraZeneca, Pfizer Inc., Shire. A.J. Owen: None. L. Chen: None. Z. Ademi: None. D.J. Magliano: None. D. Liew: Advisory Panel; Self; AstraZeneca, Bayer AG. Research Support; Self; AbbVie Inc., AstraZeneca, Bristol-Myers Squibb Company, CSL Behring, Pfizer Inc.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db19-1594-p","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T01:23:27Z","timestamp":1559697807000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":2,"title":["1594-P: The Impact of Diabetes on Productivity in China"],"prefix":"10.2337","volume":"68","author":[{"given":"THOMAS R.","family":"HIRD","sequence":"first","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ELLA","family":"ZOMER","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALICE J.","family":"OWEN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LEI","family":"CHEN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZANFINA","family":"ADEMI","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIANNA J.","family":"MAGLIANO","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DANNY","family":"LIEW","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1594-P\/59517\/1594-P-The-Impact-of-Diabetes-on-Productivity-in","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1594-P\/59517\/1594-P-The-Impact-of-Diabetes-on-Productivity-in","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T10:03:26Z","timestamp":1647165806000},"score":7.557858,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/Supplement_1\/1594-P\/59517\/1594-P-The-Impact-of-Diabetes-on-Productivity-in"}},"issued":{"date-parts":[[2019,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db19-1594-p","ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"published":{"date-parts":[[2019,6,1]]},"article-number":"1594-P"},{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T06:00:42Z","timestamp":1766901642884,"version":"3.48.0"},"reference-count":0,"publisher":"CSIRO Publishing","issue":"1","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":4068,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2014,6,30]]},"abstract":"Molecular and isotopic analyses of oils and gases can provide information on the depositional environment, maturation and age of their source rocks, and the post expulsion history of the hydrocarbons generated. Source rock analyses can determine their potential to generate hydrocarbons of varying type over specific thermal ranges, as well as demonstrating the strength of oil- or gas-to-source correlations. Together, this geochemical interpretation can provide insights about the extent of petroleum systems and can help delineate the relationships between hydrocarbon occurrences in a basin and across the continent. Oils that do not fit the well-established framework of oil families and Australian petroleum systems point to new source rock fairways. Examples include vagrant oils with lacustrine affinities found at various locations on the western Australian margin. Other examples are oil occurrences in the Gippsland Basin whose geochemical signatures contrast with the dominant non-marine oils, supporting the existence of a viable marine source rock facies. In under-explored and frontier basins, geochemical analyses of potential source rocks can provide key evidence to underpin new exploration efforts. For example, the recent acreage uptake in the Bight Basin was supported by Geoscience Australia\u2019s recovery and analysis of oil-prone marine source rocks, and in the northern Perth Basin by new geochemical analysis extending the distribution of Lower Triassic Hovea marine source rocks offshore. Geoscience Australia has now embarked on a regional petroleum geological program that includes a national source rock study aimed at identifying and characterising Australia\u2019s hydrocarbon sources, families and systems.<\/jats:p>","DOI":"10.1071\/aj13041","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T22:00:56Z","timestamp":1503352856000},"page":"415-420","source":"Crossref","is-referenced-by-count":0,"title":["Geochemical underpinnings of Australia's offshore hydrocarbon prospectivity"],"prefix":"10.1071","volume":"54","author":[{"given":"Marita","family":"Bradshaw","sequence":"first","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne","family":"Edwards","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Boreham","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Grosjean","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Totterdell","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bernecker","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Heap","sequence":"additional","affiliation":[{"name":"AGeoscience Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2014,6,30]]},"container-title":["The APPEA Journal"],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/54\/1\/415\/894184\/aj13041.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/ep\/article-pdf\/54\/1\/415\/894184\/aj13041.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T04:25:10Z","timestamp":1766895910000},"score":7.557858,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/ep\/article\/54\/1\/415\/112652\/Geochemical-underpinnings-of-Australia-s-offshore"}},"issued":{"date-parts":[[2014,6,30]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,6,30]]}},"URL":"https:\/\/doi.org\/10.1071\/aj13041","ISSN":["1326-4966","2206-8996"],"issn-type":[{"type":"print","value":"1326-4966"},{"type":"electronic","value":"2206-8996"}],"published":{"date-parts":[[2014,6,30]]}},{"indexed":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T14:47:08Z","timestamp":1696171628436},"reference-count":0,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"4_suppl","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2012,2,1]]},"abstract":" 665 <\/jats:p> Background: Clinical trials support the addition of bevacizumab (Bev) to first line chemotherapy for metastatic colorectal cancer (mCRC). However, given that there are alternate biological agents that can be used with chemotherapy; and rare but potentially serious toxicities with Bev, there has been variable use of the drug in routine care. The purpose of this study was to prospectively explore 1st<\/jats:sup> line use of Bev in routine clinical care. <\/jats:p> Methods: A multi-site data collection was initiated in July 2009 when Bev became publicly available in Australia. A particular focus was capturing information regarding clinician decision-making that is not routinely recorded or is often poorly documented. Comprehensive comorbidity data was collected, along with specific factors, both patient (pt) and disease-related, that may impact on treatment decisions. Major adverse events that may be related to Bev were also recorded. <\/jats:p> Results: For the 2-year period from July 2009-June 2011, a database search identified 278 pts diagnosed with mCRC at five participating hospitals. 240 pts (86%) had received 1st<\/jats:sup> line chemotherapy. 102 (43%) also received Bev, the majority in combination with oxaliplatin based chemotherapy (n = 81, 79%). Bev use increased significantly from 40.4% (34\/84) of all pts receiving chemotherapy in July-December 2009, to 65.8% (25\/38) in January-June 2011 (p=0.0114). Overall the most frequent reasons for clinicians advising against the use of Bev were a bleeding or asymptomatic primary in situ (n=28, 23%), known hypertension (n=14, 11%), clinical trial participation (n=14, 11%), poor performance status (n=9, 7%), and perceived risk of arterial ischemic event (n=8, 6.5%). There have been four episodes of gastro-intestinal perforation, 3 in pts receiving Bev (2.9% of Bev treated patients). <\/jats:p> Conclusions: Bev use in first line mCRC has significantly increased over time, presumably as further positive safety data emerges regarding safety in older and frailer pts, and clinician prescribing experience increases. The major grounds for not using Bev in the 1st<\/jats:sup> line mCRC setting were specific clinical contexts where the risk of adverse events may be increased. <\/jats:p>","DOI":"10.1200\/jco.2012.30.4_suppl.665","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T18:52:39Z","timestamp":1487875959000},"page":"665-665","source":"Crossref","is-referenced-by-count":1,"title":["Prescribing patterns for bevacizumab in first-line metastatic colorectal cancer: Exploring the introduction of a new drug into routine clinical practice."],"prefix":"10.1200","volume":"30","author":[{"given":"Kathryn Maree","family":"Field","sequence":"first","affiliation":[{"name":"Ludwig Institute for Cancer Research Melbourne - Parkville Branch, Melbourne, Australia; Royal Melbourne Hospital , Melbourne, Australia; Western Hospital, Melbourne, Australia; BioGrid Australia, Melbourne, Australia; Box Hill Hospital, Melbourne, Australia; Royal Melbourne Hospital, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayesh","family":"Desai","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research Melbourne - Parkville Branch, Melbourne, Australia; Royal Melbourne Hospital , Melbourne, Australia; Western Hospital, Melbourne, Australia; BioGrid Australia, Melbourne, Australia; Box Hill Hospital, Melbourne, Australia; Royal Melbourne Hospital, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Tie","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research Melbourne - Parkville Branch, Melbourne, Australia; Royal Melbourne Hospital , Melbourne, Australia; Western Hospital, Melbourne, Australia; BioGrid Australia, Melbourne, Australia; Box Hill Hospital, Melbourne, Australia; Royal Melbourne Hospital, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Kosmider","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research Melbourne - Parkville Branch, Melbourne, Australia; Royal Melbourne Hospital , Melbourne, Australia; Western Hospital, Melbourne, Australia; BioGrid Australia, Melbourne, Australia; Box Hill Hospital, Melbourne, Australia; Royal Melbourne Hospital, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susie","family":"Bae","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research Melbourne - Parkville Branch, Melbourne, Australia; Royal Melbourne Hospital , Melbourne, Australia; Western Hospital, Melbourne, Australia; BioGrid Australia, Melbourne, Australia; Box Hill Hospital, Melbourne, Australia; Royal Melbourne Hospital, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph James","family":"McKendrick","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research Melbourne - Parkville Branch, Melbourne, Australia; Royal Melbourne Hospital , Melbourne, Australia; Western Hospital, Melbourne, Australia; BioGrid Australia, Melbourne, Australia; Box Hill Hospital, Melbourne, Australia; Royal Melbourne Hospital, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Harold","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research Melbourne - Parkville Branch, Melbourne, Australia; Royal Melbourne Hospital , Melbourne, Australia; Western Hospital, Melbourne, Australia; BioGrid Australia, Melbourne, Australia; Box Hill Hospital, Melbourne, Australia; Royal Melbourne Hospital, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research Melbourne - Parkville Branch, Melbourne, Australia; Royal Melbourne Hospital , Melbourne, Australia; Western Hospital, Melbourne, Australia; BioGrid Australia, Melbourne, Australia; Box Hill Hospital, Melbourne, Australia; Royal Melbourne Hospital, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","container-title":["Journal of Clinical Oncology"],"language":"en","link":[{"URL":"http:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/jco.2012.30.4_suppl.665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T08:50:57Z","timestamp":1653814257000},"score":7.5577726,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/jco.2012.30.4_suppl.665"}},"issued":{"date-parts":[[2012,2,1]]},"references-count":0,"journal-issue":{"issue":"4_suppl","published-print":{"date-parts":[[2012,2,1]]}},"alternative-id":["10.1200\/jco.2012.30.4_suppl.665"],"URL":"https:\/\/doi.org\/10.1200\/jco.2012.30.4_suppl.665","ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"published":{"date-parts":[[2012,2,1]]}},{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:37:34Z","timestamp":1788928654596,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2020,10]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent or refractory Clostridioides difficile<\/jats:italic> infection (rCDI). Despite inclusion in society guidelines, the uptake of FMT therapy has been variable. Physician and patient attitudes may be a barrier to evidence\u2010based uptake of therapies; however, data assessing attitudes regarding FMT for rCDI are limited.<\/jats:p><\/jats:sec>Methods<\/jats:title>The South Australian FMT for CDI database prospectively recorded patient outcomes of FMT for CDI from August 2013 to January 2019. A total of 93 consecutive patients who underwent FMT for rCDI in South Australia were invited to participate in a 20\u2010question survey regarding the patient experience of FMT. All gastroenterologists and infectious disease physicians practicing in South Australia were invited to participate in an online survey comprised of 22 questions that addressed referral experience, indications for referral, perceived risks, and regulation and funding.<\/jats:p><\/jats:sec>Results<\/jats:title>Fifty\u2010four patients (54\/93, 58%) returned the survey, of whom 52 (96%) would recommend FMT to others, and 51 (94%) were satisfied with treatment outcome. Fifty physicians returned the online survey (50\/100, 50%), of whom 23 (46%) were concerned about disease transmission risk, and 15 (30%) believed that the risk of FMT would outweigh the benefit. Infectious diseases physicians and advanced trainees had significantly greater concern regarding the potential alteration of the microbiome than gastroenterology physicians and advanced trainees (8\/17 (47%) vs<\/jats:italic> 6\/33 (18%); P<\/jats:italic> = 0.047).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Despite high levels of patient\u2010reported satisfaction following FMT, physician\u2010reported reservations exist and may present a barrier to uptake of this therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgh3.12396","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T22:59:44Z","timestamp":1596754784000},"page":"950-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Physician and patient perceptions of fecal microbiota transplant for recurrent or refractory Clostridioides difficile<\/i> in the first 6\u2009years of a central stool bank"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4201-0173","authenticated-orcid":false,"given":"Madeleine","family":"Gill","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The Queen Elizabeth Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Blacketer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Queen Elizabeth Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Chitti","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Queen Elizabeth Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karmen","family":"Telfer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Queen Elizabeth Hospital Adelaide South Australia Australia"},{"name":"School of Medicine University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lito","family":"Papanicolas","sequence":"additional","affiliation":[{"name":"School of Medicine Flinders University Adelaide South Australia Australia"},{"name":"Department of Infectious Diseases Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M","family":"Dann","sequence":"additional","affiliation":[{"name":"BiomeBank Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily C","family":"Tucker","sequence":"additional","affiliation":[{"name":"BiomeBank Adelaide South Australia Australia"},{"name":"Department of Infectious Diseases Flinders Medical Centre Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert V","family":"Bryant","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Queen Elizabeth Hospital Adelaide South Australia Australia"},{"name":"School of Medicine University of Adelaide Adelaide South Australia Australia"},{"name":"BiomeBank Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2857-1812","authenticated-orcid":false,"given":"Samuel P","family":"Costello","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Queen Elizabeth Hospital Adelaide South Australia Australia"},{"name":"School of Medicine University of Adelaide Adelaide South Australia Australia"},{"name":"BiomeBank Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408913"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004610.pub5"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13144"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14201"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618780762"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13402"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313017"},{"key":"e_1_2_5_9_1","volume-title":"Faecal Microbiota Transplant for Recurrent Clostridium difficile Infection","author":"Excellence NIfHaC","year":"2014"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13027"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2016.10.023"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319548"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14212"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2016.01.018"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ994"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13366"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205037"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316818"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1085"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz910"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2331"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piu106"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i38.10907"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-009-1093-2"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8868"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000236628.79550.e5"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15526"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910437"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.85gr.18005"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.2905"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad9358"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2973"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/476393a"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis812"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis809"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-016-0106-1"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h6043"}],"container-title":["JGH Open"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjgh3.12396","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12396","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgh3.12396","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.12396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T05:46:27Z","timestamp":1693806387000},"score":7.557653,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.12396"}},"issued":{"date-parts":[[2020,8,6]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/jgh3.12396"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.12396","archive":["Portico"],"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"published":{"date-parts":[[2020,8,6]]},"assertion":[{"value":"2020-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:06:39Z","timestamp":1700525199221},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T00:00:00Z","timestamp":1353542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2013,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The authors present a technique for mastectomy with greater versatility for reconstruction.<\/jats:p><\/jats:sec>Methods<\/jats:title>The areola is marked and a vertical line is dropped medial to the breast axis, down towards the inframammary fold and laterally to the anterior axillary line. In large ptotic breasts, the markings are modified to reduce the skin envelope. The rotation flap is raised over the lateral half of the breast, and the remainder of the skin envelope is then separated from the breast tissue as per any other mastectomy. Skin closure is by rotation of the flap and incremental gathering of skin. An audit of 37 cases of rotation flap approach (RoFA)<\/jats:styled-content> mastectomy has been performed, evaluating complications and post\u2010reconstruction outcome using the B<\/jats:styled-content>REAST Q<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>RoFA<\/jats:styled-content> has been found to offer good access for mastectomy and lymphadenectomy. A total of 7 of 37 patients had delay in healing, and 2 patients developed haematoma. Post\u2010reconstruction outcome was scored as comparable with other published series.<\/jats:p><\/jats:sec>Discussion<\/jats:title>The RoFA<\/jats:styled-content> mastectomy has the potential to facilitate reconstructive results equivalent to skin\u2010sparing mastectomy and immediate reconstruction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.12008","type":"journal-article","created":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T11:38:54Z","timestamp":1353584334000},"page":"139-145","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rotation flap approach mastectomy"],"prefix":"10.1111","volume":"83","author":[{"given":"Nicola R.","family":"Dean","sequence":"first","affiliation":[{"name":"Flinders Medical Centre Adelaide South Australia Australia"},{"name":"Flinders University Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia 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The time-trend change in incidence of TKR relating to BMI was assessed between 2015-2018. The influence of obesity on the incidence of TKR in different age and gender groups was determined. The population attributable fraction (PAF) was then calculated to estimate the effect of obesity reduction on TKR incidence.<\/jats:p>The greatest increase in incidence of TKR was seen in patients from obese class III. The incidence rate ratio for having a TKR for obesity class III was 28.683 at those aged 18-54 years but was 2.029 at those aged >75 years. Females in obesity class III were 1.7 times more likely to undergo TKR compared to similarly classified males. The PAFs of TKR associated with overweight or obesity was 35%, estimating 12,156 cases of TKR attributable to obesity in 2018. 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However, our mechanistic understanding of chemical processes driving calcification is still evolving. Here, we report the results of a long\u2010term in situ study of coral calcification rates, photo\u2010physiology, and calcifying fluid (cf) carbonate chemistry (using boron isotopes, elemental systematics, and Raman spectroscopy) for seven species (four genera) of symbiotic corals growing in their natural environments at tropical, subtropical, and temperate locations in Western Australia (latitudinal range of ~11\u00b0). We find that changes in net coral calcification rates are primarily driven by pHcf<\/jats:sub> and carbonate ion concentration []cf<\/jats:sub> in conjunction with temperature and DICcf<\/jats:sub>. Coral pHcf<\/jats:sub> varies with latitudinal and seasonal changes in temperature and works together with the seasonally varying DICcf<\/jats:sub> to optimize []cf<\/jats:sub> at species\u2010dependent levels. Our results indicate that corals shift their pHcf<\/jats:sub> to adapt and\/or acclimatize to their localized thermal regimes. This biological response is likely to have critical implications for predicting the future of coral reefs under CO2<\/jats:sub>\u2010driven warming and acidification.<\/jats:p>","DOI":"10.1111\/gcb.14488","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T04:28:49Z","timestamp":1542688129000},"page":"431-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Environmental and physiochemical controls on coral calcification along a latitudinal temperature gradient in Western Australia"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3595-1469","authenticated-orcid":false,"given":"Claire L.","family":"Ross","sequence":"first","affiliation":[{"name":"School of Earth Sciences The University of Western Australia Crawley Western Australia Australia"},{"name":"Oceans Institute The University of Western Australia Crawley Western Australia Australia"},{"name":"ARC Centre of Excellence for Coral Reef Studies The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3269-1320","authenticated-orcid":false,"given":"Thomas M.","family":"DeCarlo","sequence":"additional","affiliation":[{"name":"Oceans Institute The University of Western Australia Crawley Western Australia Australia"},{"name":"ARC Centre of Excellence for Coral Reef Studies The University of Western Australia Crawley Western Australia Australia"},{"name":"Oceans Graduate School The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm T.","family":"McCulloch","sequence":"additional","affiliation":[{"name":"Oceans Institute The University of Western Australia Crawley Western Australia Australia"},{"name":"ARC Centre of Excellence for Coral Reef Studies The University of Western Australia Crawley Western Australia Australia"},{"name":"Oceans Graduate School The University of Western Australia Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,19]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"AIMS(2018).Australian Institute of Marine Science weather stations data export. 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E. N.","year":"1995"},{"key":"e_1_2_9_101_1","first-page":"176","volume-title":"Corals of the world","author":"Veron J. E. N.","year":"2000"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1029\/2010GL046474"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-0637(98)00018-1"},{"key":"e_1_2_9_104_1","volume-title":"CO2 in Seawater: Equilibrium (Kinetics, Isotopes) CO2 in seawater: Equilibrium (kinetics, isotopes)","author":"Zeebe R.","year":"2001"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09983"},{"issue":"2","key":"e_1_2_9_106_1","first-page":"157","article-title":"Cloning of a calcium channel \u03b11 subunit from the reef\u2010building coral","volume":"227","author":"Zoccola D.","year":"1999","journal-title":"Stylophora Pistillata. Gene"}],"container-title":["Global Change Biology"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fgcb.14488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gcb.14488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/gcb.14488","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gcb.14488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T07:38:03Z","timestamp":1694245083000},"score":7.557305,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gcb.14488"}},"issued":{"date-parts":[[2018,11,19]]},"references-count":105,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/gcb.14488"],"URL":"https:\/\/doi.org\/10.1111\/gcb.14488","archive":["Portico"],"ISSN":["1354-1013","1365-2486"],"issn-type":[{"value":"1354-1013","type":"print"},{"value":"1365-2486","type":"electronic"}],"published":{"date-parts":[[2018,11,19]]},"assertion":[{"value":"2018-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:14:04Z","timestamp":1781104444385,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2021,11]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To describe the incidence and long\u2010term outcome of non\u2010gonococcal septic arthritis (SA) in Western Australia (WA).<\/jats:p><\/jats:sec>Methods<\/jats:title>Newman criteria were applied to define culture\u2010positive SA and suspected SA cases in the state\u2010wide West Australian Rheumatic Diseases Epidemiological Registry with longitudinally linked health data for patients >16\u00a0years with a first diagnostic code of pyogenic arthritis (711.xx [ICD\u20109\u2010CM] and M00.xx [ICD\u201010\u2010AM]) between 1990\u20102010. Annual incidence rates\/100\u00a0000 (AIR) and standardized (against WA population) mortality rates\/1000 person\u2010years (SMR) and outcomes during 10.1\u00a0years follow\u2010up are reported.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 2633 SA patients (68.6% male, age 47.4\u00a0years), 1146 (43.5%) had culture\u2010positive SA. The overall AIR for culture\u2010positive (1.6\u20106.3) and total SA cases (4.3\u201012.9) increased between 1990 and 2010 as did age at onset (39.5\u201054\u00a0years) and proportion of females (23\u201035.6%). Knees (33.6.%) were most frequently affected and 37.1% of cultures showed microorganisms other than Gram\u2010positive cocci. Thirty\u2010day rates for readmission and mortality were 25.4% and 3.2.%. During follow\u2010up rates for serious infections (56.4%), osteoarthrosis (5.2%) and osteomyelitis (2.7%) were higher in culture\u2010positive SA. SMR was increased for all SA patients but especially in those 17\u201040 years of age with culture\u2010positive SA (24.2; 95% CI 2.3\u2010261).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The incidence of SA in WA has risen steeply over 20\u00a0years. SA now occurs at higher age, affects females more often with over a third of cases caused by Gram\u2010negative microorganisms. Not only culture\u2010positive, but also suspected SA led to increased bone\/joint complications, in\u2010hospital and late mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14221","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T16:12:26Z","timestamp":1633623146000},"page":"1386-1393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Non\u2010gonococcal septic arthritis of native joints in Western Australia. A longitudinal population\u2010based study of frequency, risk factors and outcome"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2833-7997","authenticated-orcid":false,"given":"Johannes","family":"Nossent","sequence":"first","affiliation":[{"name":"Department Rheumatology Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"Rheumatology Group School of Medicine University Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2537-0070","authenticated-orcid":false,"given":"Warren","family":"Raymond","sequence":"additional","affiliation":[{"name":"Rheumatology Group School of Medicine University Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8469-2424","authenticated-orcid":false,"given":"Helen","family":"Keen","sequence":"additional","affiliation":[{"name":"Rheumatology Group School of Medicine University Western Australia Perth Western Australia Australia"},{"name":"Department Rheumatology Fiona Stanley Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Preen","sequence":"additional","affiliation":[{"name":"School of Population and Global Health University Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0535-963X","authenticated-orcid":false,"given":"Charles A","family":"Inderjeeth","sequence":"additional","affiliation":[{"name":"Department Rheumatology Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"Rheumatology 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Journal of Rheumatic Diseases"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14221","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:04:48Z","timestamp":1693209888000},"score":7.5571012,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14221"}},"issued":{"date-parts":[[2021,10,5]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/1756-185X.14221"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14221","archive":["Portico"],"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"published":{"date-parts":[[2021,10,5]]},"assertion":[{"value":"2021-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T19:51:44Z","timestamp":1776023504921,"version":"3.50.1"},"reference-count":67,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2015,7,22]]},"published-print":{"date-parts":[[2016,2]]},"abstract":"\n Aims<\/jats:title>\n Myeloproliferative neoplasms (MPN) are a heterogeneous group of clonal proliferative bone marrow diseases characterised by extensive megakaryocytic hyperplasia and morphological atypia. Despite knowledge of genomic defects, the pathobiological processes driving these megakaryocytic abnormalities in MPN remain poorly explained. We have explored the proliferative, apoptotic and epigenetic profiles of megakaryocytes in human MPN.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Immunohistochemical staining was performed on bone marrow trephine biopsies of 81 MPN (with and without JAK2<\/jats:italic>\n V617F<\/jats:sup> and CALR<\/jats:italic> mutations) and 15 normal controls to assess the megakaryocytic expression of biomarkers associated with proliferation (Ki67), apoptosis (Bcl-XL, BNIP-3) and epigenetic regulation (EZH2, SUZ12).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Myeloproliferative megakaryocytes showed significantly greater expression of proliferative Ki67 and anti-apoptotic Bcl-XL, reduced pro-apoptotic BNIP-3 and increased SUZ12 compared with controls. In essential thrombocythaemia, large-giant megakaryocytes with hyperlobated nuclei showed a trend towards a proliferative signature. In contrast, myelofibrotic megakaryocytes with condensed nuclear chromatin, and cases with CALR<\/jats:italic> mutations, had significant reductions in pro-apoptotic BNIP-3.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Uncontrolled megakaryocytic expansion in MPN results from a combination of increased proliferation, attenuated apoptosis and defective epigenetic regulation with CALR<\/jats:italic> mutations favouring apoptotic failure. The higher platelet counts reported to be seen in MPN with CALR<\/jats:italic> mutations may be due to greater dysregulation of megakaryocyte apoptosis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/jclinpath-2015-203177","type":"journal-article","created":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T22:59:49Z","timestamp":1440025189000},"page":"155-163","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Megakaryocytic hyperplasia in myeloproliferative neoplasms is driven by disordered proliferative, apoptotic and epigenetic mechanisms"],"prefix":"10.1136","volume":"69","author":[{"given":"Jacques A J","family":"Malherbe","sequence":"first","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn A","family":"Fuller","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayesha","family":"Arshad","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoti","family":"Nangalia","sequence":"additional","affiliation":[{"name":"Cambridge Institute for Medical Research and Wellcome Trust\/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliana","family":"Romeo","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia"},{"name":"PathWest Laboratory Medicine, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara L","family":"Hall","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia"},{"name":"PathWest Laboratory Medicine, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9179-4592","authenticated-orcid":false,"given":"Katie S","family":"Meehan","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Howman","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia"},{"name":"PathWest Laboratory Medicine, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy N","family":"Erber","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia"},{"name":"PathWest Laboratory Medicine, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,8,19]]},"reference":[{"key":"2025092509114561000_69.2.155.1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-79962-9_10"},{"key":"2025092509114561000_69.2.155.2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.8711"},{"key":"2025092509114561000_69.2.155.3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-083501"},{"key":"2025092509114561000_69.2.155.4","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP2UG9SGGWAHUA"},{"key":"2025092509114561000_69.2.155.5","unstructured":"Swerdlow SH , Campo E , Harris NL , et al . 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Science Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Aims<\/jats:title>\n Inflammatory bowel disease (IBD) is a chronic autoimmune disorder. However, inconsistencies in diagnostic processes exist. This scoping review aimed to evaluate current global clinical practice guidelines (CPGs) to assist clinical decision\u2010making.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses extension for Scoping Reviews (PRISMA\u2010Scr) was utilised. CPGs were identified by searching electronic databases Medline, Scopus, Embase and grey literature until March 2024. Included guidelines were published within the last 5 years in English, with recommendations for diagnosis of IBD. Publications were independently extracted and critically appraised by two reviewers using the AGREE\u2010II tool. Diagnostic recommendations were extracted and categorized.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Eleven CPGs met the inclusion criteria of this review. A total of 21 recommendations were identified and classified in relation to medical history and physical examination, blood testing, computed tomography (CT), sonography, endoscopy, colonoscopy, and magnetic resonance imaging (MRI).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Diagnostic recommendations varied across CPGs, reflecting differences in regional practices and methodological rigor. The methodological quality was inconsistent, particularly regarding the applicability of recommendations. The findings highlight the need for harmonization of diagnostic criteria, improved guideline development processes, and further research to address gaps in clinical guidance and implementation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hsr2.71382","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T05:29:46Z","timestamp":1760506186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Practice Guidelines for the Diagnosis of Inflammatory Bowel Disease (IBD): A Scoping Review"],"prefix":"10.1002","volume":"8","author":[{"given":"Chelsea","family":"Doyle","sequence":"first","affiliation":[{"name":"UniSA Allied Health & Human Performance University of South Australia South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Combes","sequence":"additional","affiliation":[{"name":"UniSA Allied Health & Human Performance University of South Australia South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meri","family":"Lioulios","sequence":"additional","affiliation":[{"name":"UniSA Allied Health & Human Performance University of South Australia South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Koutsouridis","sequence":"additional","affiliation":[{"name":"UniSA Allied Health & Human Performance University of South Australia South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Leyshon","sequence":"additional","affiliation":[{"name":"UniSA Allied Health & Human Performance University of South Australia South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7328-6677","authenticated-orcid":false,"given":"Elio","family":"Arruzza","sequence":"additional","affiliation":[{"name":"UniSA Allied Health & Human Performance University of South Australia South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.1103713"},{"key":"e_1_2_11_3_1","unstructured":"Gastroenterological Society of Australia (GESA). Inflammatory Bowel Disease Clinical Update. (2018).https:\/\/www.gesa.org.au\/public\/13\/files\/Education%20%26%20Resources\/Clinical%20Practice%20Resources\/IBD\/2018_IBD_Clinical_Update_May_update.pdf."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(01)00002-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30333-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.01.001"},{"issue":"8","key":"e_1_2_11_8_1","article-title":"A Review of Four Practice Guidelines of Inflammatory Bowel Disease","volume":"13","author":"Okobi O. 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German Society for Digestive and Metabolic Diseases (DGVS)","volume":"57","author":"Kucharzik T.","year":"2029","journal-title":"Journal of Gastroenterology"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijri.IJRI_153_18"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000152"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2020.01.030"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i43.6710"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-021-01784-1"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.5114\/pg.2021.110914"},{"issue":"1","key":"e_1_2_11_20_1","first-page":"1","article-title":"Saudi Arabia Consensus Guidance for the Diagnosis and Management of Adults With Inflammatory Bowel Disease","volume":"29","author":"Mosli M. 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A.","year":"2023","journal-title":"Coloproctology"}],"container-title":["Health Science Reports"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.71382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T04:05:36Z","timestamp":1765512336000},"score":7.557017,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.71382"}},"issued":{"date-parts":[[2025,10]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/hsr2.71382"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.71382","archive":["Portico"],"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71382"},{"institution":[{"name":"Research Square"}],"indexed":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T18:43:34Z","timestamp":1665773014626},"posted":{"date-parts":[[2022,10,14]]},"group-title":"In Review","reference-count":66,"publisher":"Research Square Platform LLC","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"accepted":{"date-parts":[[2022,10,10]]},"abstract":"Abstract<\/jats:title>\n Global high-throughput phosphoproteomic profiling is increasingly being applied to cancer specimens to identify the oncogenic signaling cascades responsible for promoting disease initiation and disease progression; pathways that are often invisible to genomics analysis. Hence, phosphoproteomic profiling has enormous potential to inform and improve individualized anti-cancer treatment strategies. However, to achieve the adequate phosphoproteomic depth and coverage necessary to identify the activated, and hence, targetable kinases responsible for driving oncogenic signaling pathways; affinity phosphopeptide enrichment techniques are required and often coupled with offline high-pressure liquid chromatographic (HPLC) separation prior to nanoflow liquid chromatography\u2013tandem mass spectrometry (nLC-MS\/MS). These complex and time-consuming procedures, limit the utility of phosphoproteomics for the analysis of individual cancer patient specimens in real-time, and restrict phosphoproteomics to specialized laboratories often outside of the clinical setting. To address these limitations, here we have optimized a new protocol, phospho-Heavy-labeled-spiketide FAIMS Stepped-CV DDA (pHASED), that employs online phosphoproteome deconvolution using high-field asymmetric waveform ion mobility spectrometry (FAIMS) and internal phosphopeptide standards to provide accurate label-free quantitation (LFQ) data in real-time. Compared with traditional single-shot LFQ phosphoproteomics workflows, pHASED provided increased phosphoproteomic depth and coverage (phosphopeptides\u2009=\u20094,617 pHASED, 2,789 LFQ), whilst eliminating the variability associated with offline prefractionation. pHASED was optimized using tyrosine kinase inhibitor (sorafenib) resistant isogenic FLT3-mutant acute myeloid leukemia (AML) cell line models. Bioinformatic analysis identified differential activation of the Serine\/threonine protein kinase ataxia-telangiectasia mutated (ATM) pathway, responsible for sensing and repairing DNA damage in sorafenib-resistant AML cell line models, thereby uncovering a potential therapeutic opportunity. Herein, we have optimized a rapid, reproducible, and flexible protocol for the characterization of complex cancer phosphoproteomes in real-time; a step towards the implementation of phosphoproteomics in the clinic to aid in the selection of anti-cancer therapies for patients.<\/jats:p>","DOI":"10.21203\/rs.3.rs-2152430\/v1","type":"posted-content","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T18:15:13Z","timestamp":1665771313000},"source":"Crossref","is-referenced-by-count":0,"title":["Phospho heavy-labeled-spiketide FAIMS stepped-CV DDA (pHASED) provides real-time phosphoproteomics data to aid in cancer drug selection"],"prefix":"10.21203","author":[{"given":"Dilana E.","family":"Staudt","sequence":"first","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather C.","family":"Murray","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Skerrett-Byrne","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan D.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad F.","family":"Jamaluddin","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard G.S.","family":"Kahl","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan J.","family":"Duchatel","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zacary P.","family":"Germon","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tabitha","family":"McLachlan","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangeline R.","family":"Jackson","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izac J.","family":"Findlay","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padraic S.","family":"Kearney","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul","family":"Mannan","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly P.","family":"McEwen","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia M.","family":"Douglas","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett","family":"Nixon","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M.","family":"Verrills","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D.","family":"Dun","sequence":"additional","affiliation":[{"name":"University of Newcastle Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8761","reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41388-021-02102-y","article-title":"Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies","volume":"41","author":"Findlay IJ","year":"2022","unstructured":"Findlay IJ, De Iuliis GN, Duchatel RJ, Jackson ER, Vitanza NA, Cain JE, Waszak SM, Dun MD. 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Diagnostic imaging plays an important role in the preoperative workup. We sought to determine the utility of single sagittal T2\u2010weighted MRI motion sequence in the preoperative assessment of pelvic mobility in patients with endometriosis.<\/jats:p><\/jats:sec>Methods<\/jats:title>An observational study at a single tertiary public referral centre in Australia. Eighty\u2010one MRI studies from 1 May 2019 to 3 December 2019, were enrolled. Studies were included if they were performed to stage endometriosis, including a T2\u2010weighted motion series, adequately covering a uterus, cervix and rectum. Fifty\u2010seven studies met inclusion criteria. The reference standard was a contemporaneous transvaginal ultrasound (TVUS) reporting on pelvic organ mobility. Three subspecialist radiologists were then blindly asked to identify, on the cine loop: rectouterine immobility, superficial endometriosis (pelvic bowel adhesions), rectosigmoid Deep Infiltrating Endometriosis (DIE). Fleiss\u2019 Kappa assessed interobserver agreement. Consensus MRI sensitivity and specificity were estimated against the reference standard (TVUS).<\/jats:p><\/jats:sec>Results<\/jats:title>Median age was 35\u2009years (range 19\u201351). Forty\u2010three cases had a contemporaneous TVUS; 14 reporting a sliding sign, 29 with fixed pelves. Interobserver agreement was \u2018substantial\u2019 (k<\/jats:italic>\u2009=\u20090.79) for absent MRI sliding sign and \u2018almost perfect\u2019 (k<\/jats:italic>\u2009=\u20090.90) for absence of DIE. Consensus MRI had 90% sensitivity (95% CI 73\u201398%) for pelvic immobility at TVUS (absent sliding sign). Interobserver agreement and consensus MRI sensitivity were higher for adhesions and immobility than normal findings.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>An MRI motion sequence can identify patients with pelvic adhesions and immobility, helping determine surgical difficulty when TVUS is not diagnostic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1754-9485.13283","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T12:46:52Z","timestamp":1625834812000},"page":"54-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["MRI sliding sign: Using MRI to assess rectouterine mobility in pelvic endometriosis"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1159-3249","authenticated-orcid":false,"given":"Jim","family":"Fan","sequence":"first","affiliation":[{"name":"King Edward Memorial Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"McDonnell","sequence":"additional","affiliation":[{"name":"King Edward Memorial Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Jacques","sequence":"additional","affiliation":[{"name":"Department of Research Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"Institute for Health Research The University of Notre Dame Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Fender","sequence":"additional","affiliation":[{"name":"King Edward Memorial Hospital Perth Western Australia Australia"},{"name":"Department of Radiology Sir Charles Gairdner Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6906-588X","authenticated-orcid":false,"given":"Glen","family":"Lo","sequence":"additional","affiliation":[{"name":"King Edward Memorial Hospital Perth Western Australia Australia"},{"name":"Department of Radiology Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"BreastScreen WA Perth Western Australia Australia"},{"name":"The University of Western Australia Perth Western Australia Australia"},{"name":"Curtin University Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2007.10.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-009-0517-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12515"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17465"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12469"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-019-02124-x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3583989"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3470-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/RUQ.0000000000000458"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4615-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/2530702"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2020.02.014"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-020-02434-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-019-02124-x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-020-02417-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-019-02199-6"}],"container-title":["Journal of Medical Imaging and Radiation Oncology"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.13283","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1754-9485.13283","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1754-9485.13283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T13:37:20Z","timestamp":1693229840000},"score":7.5567555,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1754-9485.13283"}},"issued":{"date-parts":[[2021,7,9]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/1754-9485.13283"],"URL":"https:\/\/doi.org\/10.1111\/1754-9485.13283","archive":["Portico"],"ISSN":["1754-9477","1754-9485"],"issn-type":[{"value":"1754-9477","type":"print"},{"value":"1754-9485","type":"electronic"}],"published":{"date-parts":[[2021,7,9]]},"assertion":[{"value":"2021-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:13:33Z","timestamp":1754194413474},"reference-count":7,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1111\/ans.13632","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T15:38:39Z","timestamp":1476286719000},"page":"744-745","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Breast localization techniques and margin definitions used by Australian and New Zealand surgeons"],"prefix":"10.1111","volume":"86","author":[{"given":"Donna B.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Royal Perth Hospital Perth Western Australia Australia"},{"name":"School of Surgery University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita G.","family":"Bourke","sequence":"additional","affiliation":[{"name":"School of Surgery University of Western Australia Perth Western Australia Australia"},{"name":"Breast Clinic Sir Charles Gairdner Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max M.","family":"Hobbs","sequence":"additional","affiliation":[{"name":"Department of Radiology Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenys","family":"Dixon","sequence":"additional","affiliation":[{"name":"School of Surgery University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Phillips","sequence":"additional","affiliation":[{"name":"Harry Perkins Institute for Medical Research University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christobel M.","family":"Saunders","sequence":"additional","affiliation":[{"name":"School of Surgery University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,4]]},"reference":[{"key":"e_1_2_3_2_1","volume-title":"Breast Cancer in Australia: An Overview","author":"Australia AIoHaWC","year":"2012"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.13146"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-012-0427-1"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/era.11.116"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2011.01198.x"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3957-2"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2076-8"}],"container-title":["ANZ Journal of Surgery"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.13632","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.13632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.13632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:37:22Z","timestamp":1695490642000},"score":7.5565968,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.13632"}},"issued":{"date-parts":[[2016,10]]},"references-count":7,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/ans.13632"],"URL":"https:\/\/doi.org\/10.1111\/ans.13632","archive":["Portico"],"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"2015-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:27:13Z","timestamp":1784651233369,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["OVS"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Purpose<\/jats:title>\n To examine if clusters of colocated damaged locations repeatedly found during prior SITA\u2010Standard (SS) visual field tests are not replicated in a subsequent SITA\u2010Faster (SFR) test.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Visual field series from the Lions Eye Institute, Perth, Australia were extracted if they had at least 4 SS fields followed by a SFR field and all fields had false positive rates and fixation losses less than 15%. Clusters of damaged locations were defined as either an isolated location with no damaged neighbors or a group of connected 24\u20102 points (not crossing the horizontal) that all had Pattern Deviation (PD) probability values below 1% of normal in all 3 SS tests immediately preceding the SFR test. For each cluster, the number of locations that were damaged in the SFR field that overlapped the established and repeatable SS clusters was computed and reported. We compare this proportion of overlap against the same calculations using the last SS as the final field. We also examine the effect of relaxing the PD criteria for damage in the final field on the proportion of overlap.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n 2519 eyes were included. For established, repeatable, and clusters of size 1, 2, 3, and 4 locations, the follow\u2010up SFR field completely missed 46%, 26%, 11%, and 14% of the clusters whereas SS missed significantly less 26%, 11%, 4% and 1% (\n t<\/jats:italic>\n \u2010test with mixed paired and unpaired observations and\n p<\/jats:italic>\n \u00a0<\u00a00.05). Relaxing the criteria for damage in the final field to PD < 5% reduced the miss rates for both methods, but SFR was still significantly worse than SS (SFR: 24%, 8%, 3%, and 6% vs. SS: 13%, 3%, 1%, and 1%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n SITA\u2010Faster tends to miss established clusters of damaged locations of size 4 or fewer locations in follow up visits at a higher rate than SITA\u2010Standard.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ovs2.70032","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T03:20:01Z","timestamp":1776914401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Small areas of damage due to glaucoma are less likely to be identified by SITA\u2010Faster than SITA\u2010Standard"],"prefix":"10.1002","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2559-8769","authenticated-orcid":false,"given":"Andrew","family":"Turpin","sequence":"first","affiliation":[{"name":"Lions Eye Institute Perth Western Australia Australia"},{"name":"School of Population Health Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasanth","family":"Muthusamy","sequence":"additional","affiliation":[{"name":"Lions Eye Institute Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Lions Eye Institute Perth Western Australia Australia"},{"name":"Centre for Ophthalmology & Vision Science The University of Western Australia Crawley Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Chan","sequence":"additional","affiliation":[{"name":"Lions Eye Institute Perth Western Australia Australia"},{"name":"Centre for Ophthalmology & Vision Science The University of Western Australia Crawley Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison M.","family":"McKendrick","sequence":"additional","affiliation":[{"name":"Lions Eye Institute Perth Western Australia Australia"},{"name":"Department of Optometry & Vision Science The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100420.1998.760303.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100420.1998.760208.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100420.1997.tb00392.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.10.010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoint.2025.100116"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.03.032"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201011044\u20108"},{"key":"e_1_2_8_9_1","first-page":"2654","article-title":"Properties of perimetric threshold estimates from full threshold, SITA standard, and SITA fast strategies","volume":"43","author":"Artes PH","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06\u20100685"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03\u20100023"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.04.019"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/08164622.2021.1965461"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2023.06.018"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogla.2021.10.003"}],"container-title":["Optometry and Vision Science"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ovs2.70032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ovs2.70032","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ovs2.70032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:23:29Z","timestamp":1777433009000},"score":7.5565968,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ovs2.70032"}},"issued":{"date-parts":[[2026,3]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ovs2.70032"],"URL":"https:\/\/doi.org\/10.1002\/ovs2.70032","archive":["Portico"],"ISSN":["1040-5488","1538-9235"],"issn-type":[{"value":"1040-5488","type":"print"},{"value":"1538-9235","type":"electronic"}],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70032"},{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:41:24Z","timestamp":1777664484873,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T00:00:00Z","timestamp":1325116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Health Educ Behav"],"published-print":{"date-parts":[[2012,10]]},"abstract":"Background. To influence adolescent health, a greater understanding of time use and covariates such as gender is required. Purpose. To explore gender-specific time use patterns in Australian adolescents using high-resolution time use data. Method. This study analyzed 24-hour recall time use data collected as part of the 2007 Australian National Children\u2019s Nutrition and Physical Activity Survey ( n = 2,200). Univariate analyses to determine gender differences in time use were conducted. Results. Boys spent more ( p < .0001) time participating in screen-based (17.7 % vs. 14.2% daily time) and physical activities (10.7% vs. 9.2%). Girls spent more ( p < .0001) time being social (4.7% vs. 3.4% daily time), studying (2.0% vs. 1.7%), and doing household chores (4.7% vs. 3.4%). Conclusions. There are gender-specific differences in time use behavior among Australian adolescents. The results reinforce existing time use gender-based stereotypes. Implications. The gender-specific time use behaviors offer intervention design possibilities.<\/jats:p>","DOI":"10.1177\/1090198111423942","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T23:49:04Z","timestamp":1325202544000},"page":"589-595","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":41,"title":["All the Stereotypes Confirmed"],"prefix":"10.1177","volume":"39","author":[{"given":"Katia E.","family":"Ferrar","sequence":"first","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim S.","family":"Olds","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie L.","family":"Walters","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,12,29]]},"reference":[{"key":"bibr1-1090198111423942","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(98)00080-4"},{"key":"bibr2-1090198111423942","doi-asserted-by":"publisher","DOI":"10.1123\/pes.12.1.71"},{"key":"bibr3-1090198111423942","unstructured":"Department of Health and Ageing. (2008). 2007 Australian national children\u2019s nutrition and physical activity survey. Retrieved from http:\/\/www.health.gov.au\/internet\/main\/publishing.nsf\/Content\/phd-nutrition-childrens-survey-keyfindings"},{"key":"bibr4-1090198111423942","first-page":"6","author":"Douglas C. A.","year":"2002","journal-title":"Off Our Backs, 43"},{"key":"bibr5-1090198111423942","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9280.2007.01990.x"},{"key":"bibr6-1090198111423942","doi-asserted-by":"publisher","DOI":"10.1111\/j.1746-1561.2009.00454.x"},{"key":"bibr7-1090198111423942","doi-asserted-by":"publisher","DOI":"10.2307\/354018"},{"key":"bibr8-1090198111423942","unstructured":"GISCA. (2010). ARIA\u2014Accessibility\/Remoteness Index of Australia. Retrieved from http:\/\/gisca.adelaide.edu.au\/projects\/aria_project.html"},{"key":"bibr9-1090198111423942","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.125.6.701"},{"key":"bibr10-1090198111423942","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2010.04.004"},{"key":"bibr11-1090198111423942","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5868-5-8"},{"key":"bibr12-1090198111423942","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2008.05.003"},{"key":"bibr13-1090198111423942","doi-asserted-by":"publisher","DOI":"10.1123\/pes.22.1.34"},{"key":"bibr14-1090198111423942","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5868-3-10"},{"key":"bibr15-1090198111423942","doi-asserted-by":"publisher","DOI":"10.1177\/109019810202900408"},{"key":"bibr16-1090198111423942","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(02)00042-4"},{"key":"bibr17-1090198111423942","doi-asserted-by":"publisher","DOI":"10.1080\/01443410500341023"}],"container-title":["Health Education & Behavior"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1090198111423942","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1090198111423942","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1090198111423942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:36:13Z","timestamp":1777448173000},"score":7.556581,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1090198111423942"}},"subtitle":["Differences in How Australian Boys and Girls Use Their Time"],"issued":{"date-parts":[[2011,12,29]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1177\/1090198111423942"],"URL":"https:\/\/doi.org\/10.1177\/1090198111423942","ISSN":["1090-1981","1552-6127"],"issn-type":[{"value":"1090-1981","type":"print"},{"value":"1552-6127","type":"electronic"}],"published":{"date-parts":[[2011,12,29]]}},{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:01:28Z","timestamp":1783364488691,"version":"3.54.6"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,5]],"date-time":"2021-09-05T00:00:00Z","timestamp":1630800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Prom J of Aust"],"published-print":{"date-parts":[[2022,7]]},"abstract":"Abstract<\/jats:title>Issue addressed<\/jats:title>Alcoholic products marketed as better\u2010for\u2010you is an emerging trend in Australia that has received limited research attention to date. This study aimed to examine the nutrient profiles of alcoholic products marketed as better\u2010for\u2010you that are available in the Australian market.<\/jats:p><\/jats:sec>Methods<\/jats:title>We extracted the details of alcoholic product announcements published on the Drinks Trade website in 2019 and 2020 containing at least one keyword used to promote better\u2010for\u2010you products. The alcohol, energy, carbohydrate and sugar content of each product was recorded and assessed against existing classifications for alcohol strength and sugar and carbohydrate content.<\/jats:p><\/jats:sec>Results<\/jats:title>We identified 144 products promoted as better\u2010for\u2010you. The majority of products (85%, n\u00a0=\u00a0122) were classified as full\u2010strength, and the median alcohol content across each alcohol product category was classified as full\u2010strength. Most of the energy content came from alcohol, with 62% of products deriving at least 75% of their energy content from alcohol.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Alcoholic products marketed as better\u2010for\u2010you appear to rely on an illusion of healthfulness, without addressing the ingredient of most concern to health, the alcohol content.<\/jats:p><\/jats:sec>So what?<\/jats:title>Controls on alcohol marketing should be expanded to limit the use of health and nutrient claims. Mandatory labelling of alcoholic products with nutrition information would support consumers to be better informed about the contents of alcoholic products.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hpja.531","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T17:36:53Z","timestamp":1629221813000},"page":"782-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Health halo or genuine product development: Are better\u2010for\u2010you alcohol products actually healthier?"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-2062","authenticated-orcid":false,"given":"Danica","family":"Keric","sequence":"first","affiliation":[{"name":"Cancer Council Western Australia Subiaco Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3521-2842","authenticated-orcid":false,"given":"Gael","family":"Myers","sequence":"additional","affiliation":[{"name":"Cancer Council Western Australia Subiaco Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5959-0525","authenticated-orcid":false,"given":"Julia","family":"Stafford","sequence":"additional","affiliation":[{"name":"Cancer Council Western Australia Subiaco Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,5]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Global status report on alcohol and health 2018","author":"World Health Organization","year":"2018"},{"key":"e_1_2_8_3_1","unstructured":"Australian Bureau of Statistics.Australian Health Survey: Nutrition first results \u2013 foods and nutrients.2014."},{"key":"e_1_2_8_4_1","volume-title":"RTD mixed spirit production in Australia OD5138","author":"Reeves M","year":"2020"},{"issue":"3","key":"e_1_2_8_5_1","article-title":"Proliferation of \u2018healthy\u2019 alcohol products in Australia: implications for policy","volume":"29","author":"Keric D","year":"2019","journal-title":"Public Health Res Pract"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2010.tb03488.x"},{"key":"e_1_2_8_7_1","unstructured":"Cancer Council Victoria.Is \u2018low carb\u2019 beer really better for you? New analysis shows it\u2019s a big fat myth[Internet]. Melbourne:Cancer Council Victoria;2018Apr 20 [cited 2021 Apr 23]. Available from:https:\/\/www.cancervic.org.au\/about\/media\u2010releases\/2018\u2010media\u2010releases\/april\u20102018\/is\u2010low\u2010carb\u2010beer\u2010really\u2010better\u2010for\u2010you\u2010new\u2010analysis\u2010shows\u2010its\u2010a\u2010big\u2010fat\u2010myth.html"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980018002392"},{"key":"e_1_2_8_9_1","unstructured":"Drinks Trade.Drinks Media Kit 2020\u201021. West Pymble: Hip Media;2021[cited 2021 Mar 8]. Available from:https:\/\/www.drinkstrade.com.au\/full\u2010media\u2010pack"},{"key":"e_1_2_8_10_1","unstructured":"Liquor Control Act 1988 (WA) s. 3 (Austl.). [cited 2021 Apr 23]. Available from:https:\/\/www.legislation.wa.gov.au\/legislation\/statutes.nsf\/main_mrtitle_546_homepage.html"},{"key":"e_1_2_8_11_1","unstructured":"Food Standards Australia and New Zealand. Australia New Zealand Food Standards Code \u2010 Standard 2.7.1 \u2010 Labelling of alcoholic beverages and food containing alcohol. Canberra: Food Standards Australia and New Zealand;2020. [cited Apr 23 2021]. Available from:https:\/\/www.legislation.gov.au\/Series\/F2015L00469"},{"key":"e_1_2_8_12_1","unstructured":"Food Standards Australia and New Zealand. Australia New Zealand Food Standards Code \u2013 Standard 2.7.2 \u2013 Beer. Canberra: Food Standards Australia and New Zealand;2015. [cited Apr 23 2021]. Available from:https:\/\/www.legislation.gov.au\/Series\/F2015L00384"},{"key":"e_1_2_8_13_1","unstructured":"Food Standards Australia and New Zealand. Australia New Zealand Food Standards Code \u2010 Standard 2.7.3 \u2010 Fruit wine vegetable wine and mead. Canberra: Food Standards Australia and New Zealand;2015. [cited Apr 23 2021]. Available from:https:\/\/www.legislation.gov.au\/Series\/F2015L00388"},{"key":"e_1_2_8_14_1","unstructured":"Food Standards Australia and New Zealand. Australia New Zealand Food Standards Code \u2010Standard 2.7.4 \u2010 Wine and wine product. Canberra: Food Standards Australia and New Zealand;2016. [cited Apr 23 2021]. Available from:https:\/\/www.legislation.gov.au\/Series\/F2015L00391"},{"key":"e_1_2_8_15_1","unstructured":"Food Standards Australia and New Zealand. Australia New Zealand Food Standards Code \u2010 Standard 2.7.5 \u2010 Spirits. Canberra: Food Standards Australia and New Zealand;2019. [cited Apr 23 2021]. 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Australia"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hpja.531","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hpja.531","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hpja.531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T14:17:29Z","timestamp":1692886649000},"score":7.556581,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hpja.531"}},"issued":{"date-parts":[[2021,9,5]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/hpja.531"],"URL":"https:\/\/doi.org\/10.1002\/hpja.531","archive":["Portico"],"ISSN":["1036-1073","2201-1617"],"issn-type":[{"value":"1036-1073","type":"print"},{"value":"2201-1617","type":"electronic"}],"published":{"date-parts":[[2021,9,5]]},"assertion":[{"value":"2021-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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Urology"],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534711027546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534711027546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2011.02.2506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:09:53Z","timestamp":1651201793000},"score":7.556238,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2011.02.2506"}},"issued":{"date-parts":[[2011,4]]},"references-count":0,"journal-issue":{"issue":"4S","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1016\/j.juro.2011.02.2506"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2011.02.2506","ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"published":{"date-parts":[[2011,4]]}},{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:30Z","timestamp":1753889850338,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2022,6,1]]},"abstract":"Background: Human NADPH oxidase 5 (NOX5) is expressed and functionally active in peripheral blood mononuclear cells (PBMCs) . In those with diabetes, there is increased NOX5 expression in atherosclerotic plaques with associated coronary artery disease (CAD) and within the glomeruli in kidney biopsies. We hypothesise that NOX5 expression in circulating PBMCs is increased in patients with diabetes, particularly in those with comorbid unstable CAD and chronic kidney disease (CKD) .<\/jats:p>\n Methods: 55 males aged 33-83 years underwent elective or emergency coronary angiography\/angioplasty at the Alfred Hospital Catheter Laboratory. PBMCs from whole blood were processed for flow-cytometry to measure NOX5 protein. In parallel, NOX5 expression was measured in PBMCs by qPCR. In vitro, human macrophages (THP-1) were incubated in normal (5 mM) and high glucose (25 mM) . NOX5 expression and inflammatory markers were measured by qPCR.<\/jats:p>\n Results: NOX5 protein expression in PBMCs was primarily driven by expression in monocytes (CD 45+\/CD14+ cells) and was increased in diabetic and non-diabetic patients with CKD (28.7\u00b14.2 vs. 17.3\u00b11.7 AU; p=0.0038) and in diabetic patients with CKD versus without CKD (27.5\u00b14.1 vs. 14.6\u00b12.3 AU; p=0.012) . CAD with acute presentation was associated with increased NOX5 expression versus elective presentation (25.9\u00b12.9 vs. 16.8\u00b11.9 AU; p=0.0085) , particularly in diabetic patients presenting acutely versus electively (29.1\u00b14.2 vs. 13.9\u00b12.4 AU; p=0.0025) . A 4-fold upregulation of NOX5 gene was observed in patients with CKD versus without CKD irrespective of diabetes or CAD (p=0.018) . In vitro, there was a 2-fold increase in NOX5, TNF-\u03b1 and IL-6 expression in THP-1 cells exposed to high glucose.<\/jats:p>\n Conclusion: CKD and unstable CAD appear to be key factors for increased NOX5 expression in circulating PBMCs. Measurement of NOX5 in PBMCs may serve as a valuable prognostic biomarker and attractive therapeutic target in patients with clustering diabetic complications.<\/jats:p>\n \n Disclosure<\/jats:title>\n T.J.Block: None. K.Sourris: None. W.Khan: None. P.Kantharidis: None. J.C.Jha: None. M.E.Cooper: Advisory Panel; Bayer AG, Merck Sharp & Dohme Corp., Consultant; Boehringer Ingelheim International GmbH, Research Support; Novo Nordisk, Speaker's Bureau; AstraZeneca, Servier Laboratories. J.Shaw: None. K.Jandeleit-dahm: None.<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db22-437-p","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:18:05Z","timestamp":1653974285000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["437-P: NOX5 in Human Peripheral Blood Mononuclear Cells Is a Potential Biomarker for Unstable Diabetic Vascular Disease"],"prefix":"10.2337","volume":"71","author":[{"given":"TOMASZ J.","family":"BLOCK","sequence":"first","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KARLY","family":"SOURRIS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WAHEED","family":"KHAN","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PHILLIP","family":"KANTHARIDIS","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAY C.","family":"JHA","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK E.","family":"COOPER","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAMES","family":"SHAW","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KARIN","family":"JANDELEIT-DAHM","sequence":"additional","affiliation":[{"name":"Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/437-P\/145304\/437-P-NOX5-in-Human-Peripheral-Blood-Mononuclear","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/437-P\/145304\/437-P-NOX5-in-Human-Peripheral-Blood-Mononuclear","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:18:05Z","timestamp":1653974285000},"score":7.556238,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/71\/Supplement_1\/437-P\/145304\/437-P-NOX5-in-Human-Peripheral-Blood-Mononuclear"}},"issued":{"date-parts":[[2022,6,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/db22-437-p","ISSN":["0012-1797"],"issn-type":[{"type":"print","value":"0012-1797"}],"published":{"date-parts":[[2022,6,1]]},"article-number":"437-P"},{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T13:40:45Z","timestamp":1767620445781,"version":"3.48.0"},"reference-count":0,"publisher":"American Thoracic Society","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1164\/ajrccm-conference.2020.201.1_meetingabstracts.a1240","type":"proceedings-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T22:51:19Z","timestamp":1594162279000},"page":"A1240-A1240","source":"Crossref","is-referenced-by-count":0,"title":["Quantifying Airway Smooth Muscle Thickness Using Polarization-Sensitive Optical Coherence Tomography"],"prefix":"10.1093","author":[{"given":"A.L.","family":"James","sequence":"first","affiliation":[{"name":"Sir Charles Gairdner Hosp, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cairncross","sequence":"additional","affiliation":[{"name":"University of Western Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Hackmann","sequence":"additional","affiliation":[{"name":"University of Western Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.G.","family":"Seo","sequence":"additional","affiliation":[{"name":"University of Western Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Cense","sequence":"additional","affiliation":[{"name":"University of Western Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Li","sequence":"additional","affiliation":[{"name":"University of Western Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Karnowski","sequence":"additional","affiliation":[{"name":"University of Western Australia, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Elliot","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital, Nedlands, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.C.","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Human Sciences, University of Western Australia, Crawley, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Sampson","sequence":"additional","affiliation":[{"name":"University of Surrey, Guildford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.B.","family":"Noble","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,5,1]]},"event":{"name":"American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA"},"container-title":["A30. CONTRACT AND RELAX: WHAT'S NEW IN AIRWAY SMOOTH MUSCLE MECHANISMS"],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T10:59:17Z","timestamp":1767610757000},"score":7.5561347,"resource":{"primary":{"URL":"https:\/\/www.atsjournals.org\/doi\/10.1164\/ajrccm-conference.2020.201.1_MeetingAbstracts.A1240"}},"issued":{"date-parts":[[2020,5]]},"references-count":0,"alternative-id":["10.1164\/ajrccm-conference.2020.201.1_MeetingAbstracts.A1240","10.1164\/ajrccm-conference.2020.A30"],"URL":"https:\/\/doi.org\/10.1164\/ajrccm-conference.2020.201.1_meetingabstracts.a1240","published":{"date-parts":[[2020,5]]}},{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:11:49Z","timestamp":1785222709702,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[2015,6]]},"abstract":"\n A randomized double-blind placebo-controlled study was conducted in children admitted to hospital with gastroenteritis (\u22653 loose stools per day). All were treated for 5 days following admission with either zinc (Zn, 3 mg) or without Zn-fortified rice-based oral rehydration solution (ORS).\n 13<\/jats:sup>\n C-sucrose breath test (SBT) and intestinal permeability (lactulose\/rhamnose or L\/R ratio) were performed concurrently prior to commencement of ORS with or without Zn and at day 5 post-admission. There was a significant improvement in the SBT results in both the Zn-fortified group, median (5th-95th percentile) 2.1% (0.4% to 8.3%) versus 4.4% (0.4% to 10.4%), P < .05, and control group, 1.4% (0.1% to 5.4%) versus 4.3% (0.4% to 11.4%), P < .05, between the day of admission and day 5 post-admission. In the Zn-fortified group, there was also a significant improvement in L\/R ratio between the day of admission and day 5 post-admission, 53.0 (19.5-90.6) versus 17.7 (13.4-83.2), P < .05. Low levels of Zn improved intestinal permeability but did not enhance short-term recovery following diarrheal illness.\n <\/jats:p>","DOI":"10.1177\/0009922814562665","type":"journal-article","created":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T13:39:48Z","timestamp":1418909988000},"page":"676-682","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Zinc-Fortified Oral Rehydration Solution Improved Intestinal Permeability and Small Intestinal Mucosal Recovery"],"prefix":"10.1177","volume":"54","author":[{"given":"Cuong D.","family":"Tran","sequence":"first","affiliation":[{"name":"Women\u2019s and Children\u2019s Health Network, North Adelaide, South Australia, Australia"},{"name":"University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Hawkes","sequence":"additional","affiliation":[{"name":"Women\u2019s and Children\u2019s Health Network, North Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin D.","family":"Graham","sequence":"additional","affiliation":[{"name":"University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie L.","family":"Kitchen","sequence":"additional","affiliation":[{"name":"University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin L.","family":"Symonds","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey P.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Women\u2019s and Children\u2019s Health Network, North Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross N.","family":"Butler","sequence":"additional","affiliation":[{"name":"Women\u2019s and Children\u2019s Health Network, North Adelaide, South Australia, Australia"},{"name":"University of South Australia, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,12,16]]},"reference":[{"key":"bibr1-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010386"},{"key":"bibr2-0009922814562665","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.050054"},{"key":"bibr3-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1080\/0960312031000102822"},{"key":"bibr4-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq025"},{"key":"bibr5-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6822.287"},{"key":"bibr6-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb00387.x"},{"key":"bibr7-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.112161"},{"key":"bibr8-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70086-7"},{"key":"bibr9-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.6.1516"},{"key":"bibr10-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1177\/15648265090301S103"},{"key":"bibr11-0009922814562665","unstructured":"WHO\/UNICEF. WHO\/UNICEF joint statement: clinical management of acute diarrhoea. Geneva, Switzerland: WHO\/UNICEF; 2004. http:\/\/www.unicef.org\/publications\/files\/ENAcute_Diarrhoea_reprint.pdf. Accessed November 25, 2014"},{"key":"bibr12-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200208000-00020"},{"key":"bibr13-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2257"},{"key":"bibr14-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181bbf53d"},{"key":"bibr15-0009922814562665","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.08.058990"},{"key":"bibr16-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1997.tb00340.x"},{"key":"bibr17-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31802c41b7"},{"key":"bibr18-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000214163.83316.41"},{"key":"bibr19-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2009.0075"},{"key":"bibr20-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198502000-00004"},{"key":"bibr21-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1080\/00365520410003416"},{"key":"bibr22-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(00)70107-7"},{"key":"bibr23-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1086\/653554"},{"key":"bibr24-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1086\/653579"},{"key":"bibr25-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80627-9"},{"key":"bibr26-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199210000-00010"},{"key":"bibr27-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/68.2.447S"},{"key":"bibr28-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.099929"},{"key":"bibr29-0009922814562665","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.5.1296"}],"container-title":["Clinical Pediatrics"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0009922814562665","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0009922814562665","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0009922814562665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:29:25Z","timestamp":1777393765000},"score":7.5560308,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0009922814562665"}},"issued":{"date-parts":[[2014,12,16]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1177\/0009922814562665"],"URL":"https:\/\/doi.org\/10.1177\/0009922814562665","ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"published":{"date-parts":[[2014,12,16]]}},{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T20:44:09Z","timestamp":1771620249561,"version":"3.50.1"},"reference-count":31,"publisher":"Division of International Special Education and Services (DISES)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2014,11,1]]},"abstract":"Abstract<\/jats:title>\n For young children with autism spectrum disorder (ASD) in regular schools, ASD specific service delivery options include regular class placement with itinerant consultative support and support class placement. This study provided an examination of levels of parent, teacher and principal satisfaction with both regular class placement (n = 39) and a satellite support class option (n=35), which provides a more gradual transition into regular class. Given that regular class placement was the ultimate goal for children enrolled in the study, factors that either facilitated or acted as barriers to successful inclusion were examined for those children currently in regular classes. There were relatively high levels of parent, teacher and principal satisfaction with both satellite support class and regular class placement for children with ASD, with higher levels of parental satisfaction with satellite support placement. Across all respondents, the most frequently identified facilitating factors were related to teaching practices and skills. In contrast, barriers identified were generally related to child characteristics. A number of suggestions for future research are offered.<\/jats:p>","DOI":"10.9782\/2159-4341-17.2.60","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T19:27:34Z","timestamp":1416598054000},"page":"60-69","source":"Crossref","is-referenced-by-count":16,"title":["Perspectives on Regular and Support Class Placement and Factors that Contribute to Success of Inclusion for Children with ASD"],"prefix":"10.9782","volume":"17","author":[{"given":"Mark","family":"Carter","sequence":"first","affiliation":[{"name":"Macquarie University, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Macquarie University, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Clark","sequence":"additional","affiliation":[{"name":"Autism Spectrum Australia (Aspect), Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra","family":"Costley","sequence":"additional","affiliation":[{"name":"Autism Spectrum Australia (Aspect), Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Martin","sequence":"additional","affiliation":[{"name":"Autism SA, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina","family":"Williams","sequence":"additional","affiliation":[{"name":"University of Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah","family":"Browne","sequence":"additional","affiliation":[{"name":"Macquarie University, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Davies","sequence":"additional","affiliation":[{"name":"Autism SA, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Bruck","sequence":"additional","affiliation":[{"name":"Autism Spectrum Australia (Aspect), Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4809","reference":[{"key":"2021030812302027100_i2159-4341-17-2-60-AmericanPsychiatricAssociation1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"2021030812302027100_i2159-4341-17-2-60-AutismSpectrumAustraliandAspectcomprehensiveapproachforeducationRetrieved27November1","unstructured":"Autism Spectrum Australia. (n.d.). Aspect comprehensive approach for education. Retrieved 27 November, 2012from http:\/\/www.autismspectrum.org.au\/content\/aspect-comprehensive-approach-education"},{"key":"2021030812302027100_i2159-4341-17-2-60-Barnard1","article-title":"Inclusion and autism: Is it working?","author":"Barnard","year":"2000"},{"key":"2021030812302027100_i2159-4341-17-2-60-Batten1","article-title":"Autism and education: The reality for families today","author":"Batten","year":"2006"},{"key":"2021030812302027100_i2159-4341-17-2-60-Beresford1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/chso.0.0.issue-0","article-title":"Desired outcomes for children and adolescents with autistic spectrum disorders","volume":"21","author":"Beresford","year":"2006","journal-title":"Children & Society"},{"key":"2021030812302027100_i2159-4341-17-2-60-CentersforDiseaseControlandPreventionCDC1","article-title":"Prevalence of autism spectrum disorders \u2013Autism and Developmental Disabilities Monitoring Network, United States","author":"Centers for Disease Control and Prevention (CDC)","year":"2012","journal-title":"Morbidity and Mortal Weekly Report (MMWR)"},{"key":"2021030812302027100_i2159-4341-17-2-60-Chakrabarti1","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1176\/appi.ajp.162.6.1133","article-title":"Pervasive developmental disorders in preschool children: Confirmation of high prevalence","volume":"162","author":"Chakrabarti","year":"2005","journal-title":"American Journal of Psychiatry"},{"key":"2021030812302027100_i2159-4341-17-2-60-Constantino1","unstructured":"Constantino, J. N. \n (2005). Social Responsiveness Scale (SRS). Los Angeles, CA: Western Psychological Services."},{"key":"2021030812302027100_i2159-4341-17-2-60-Elkins1","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/jrse.2003.3.issue-2","article-title":"Parents' attitudes to inclusion of their children with special needs","volume":"3","author":"Elkins","year":"2003","journal-title":"Journal of Research in Special Education Needs"},{"key":"2021030812302027100_i2159-4341-17-2-60-Frederickson1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/j.1471\u20133802.2010.01145.x","article-title":"Inclusive provision options for pupils on the autistic spectrum","volume":"10","author":"Frederickson","year":"2010","journal-title":"Journal of Research in Special Educational Needs"},{"key":"2021030812302027100_i2159-4341-17-2-60-Giangreco1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1352\/1934-9556-48.1.1","article-title":"One-to-one paraprofessionals for students with disabilities in inclusive classrooms: Is conventional wisdom wrong?","volume":"48","author":"Giangreco","year":"2010","journal-title":"Intellectual and Developmental Disabilities"},{"key":"2021030812302027100_i2159-4341-17-2-60-Giangreco2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1080\/10474410903535356","article-title":"Paraprofessionals in inclusive schools: A review of recent research","volume":"20","author":"Giangreco","year":"2010","journal-title":"Journal of Educational and Psychological Consultation"},{"key":"2021030812302027100_i2159-4341-17-2-60-Gresham1","unstructured":"Gresham, F. M., & Elliott, S. N. (2008). Social Skills Improvement System (SSIS) Rating Scales. Upper Saddle River, NJ: Pearson."},{"key":"2021030812302027100_i2159-4341-17-2-60-Jenkinson1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1080\/1034912980450205","article-title":"Parent choice in the education of students with disabilities","volume":"45","author":"Jenkinson","year":"1998","journal-title":"International Journal of Disability, Development and Education"},{"key":"2021030812302027100_i2159-4341-17-2-60-Kasari1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1023\/A:1022159302571","article-title":"Parental perspectives on inclusion: Effects of autism and Down syndrome","volume":"29","author":"Kasari","year":"1999","journal-title":"Journal of Autism and Developmental Disorders"},{"key":"2021030812302027100_i2159-4341-17-2-60-Kemp1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s10882-006-9010-z","article-title":"The contribution of academic skills to the successful inclusion of children with disabilities","volume":"18","author":"Kemp","year":"2006","journal-title":"Journal of Developmental and Physical Disabilities"},{"key":"2021030812302027100_i2159-4341-17-2-60-Kim1","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1176\/appi.ajp.2011.10101532","article-title":"Prevalence of autism spectrum disorders in a total population sample","volume":"168","author":"Kim","year":"2011","journal-title":"American Journal of Psychiatry"},{"key":"2021030812302027100_i2159-4341-17-2-60-NationalResearchCouncilEd1","unstructured":"National Research Council (Ed.). (2001). Educating children with autism. Washington, DC: National Academy Press."},{"key":"2021030812302027100_i2159-4341-17-2-60-NSWDepartmentofEducationandTrainingndFundingsupportStudentswithdisabilitiesinregularclassesSupportdocumentRetrievedNovember231","unstructured":"NSW Department of Education and Training. (n.d.). Funding support: Students with disabilities in regular classes. Support document. Retrieved November 23, 2013from http:\/\/www.schools.nsw.edu.au\/media\/downloads\/schoolsweb\/studentsupport\/programs\/disability\/supportdocument.pdf"},{"key":"2021030812302027100_i2159-4341-17-2-60-Parsons1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1080\/08856250802596790","article-title":"The views and experiences of parents of children with autistic spectrum disorder about educational provision: Comparisons with parents of children with other disabilities from an online survey","volume":"24","author":"Parsons","year":"2009","journal-title":"European Journal of Special Needs Education"},{"key":"2021030812302027100_i2159-4341-17-2-60-Renty1","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/j.1365\u20132214.2006.00584.x","article-title":"Satisfaction with formal support and education for children with autism spectrum disorder: The voices of the parents","volume":"32","author":"Renty","year":"2006","journal-title":"Child: Care, Health and Development"},{"issue":"2","key":"2021030812302027100_i2159-4341-17-2-60-Roberts1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/004005990804100203","article-title":"Making inclusion work: Autism Spectrum Australia's satellite class project","volume":"41","author":"Roberts","year":"2008","journal-title":"Teaching Exceptional Children"},{"key":"2021030812302027100_i2159-4341-17-2-60-Roberts2","unstructured":"Roberts, J. M. \n (2004). A review of the research to identify the most effective models of best practice in the management of children with autism spectrum disorders. Sydney, Australia: Centre for Developmental Disability Studies."},{"key":"2021030812302027100_i2159-4341-17-2-60-Spann1","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1177\/10883576030180040401","article-title":"Examining parents' involvement in and perceptions of special education services: An interview with families in a parent support group","volume":"18","author":"Spann","year":"2003","journal-title":"Focus on Autism and Other Developmental Disabilities"},{"key":"2021030812302027100_i2159-4341-17-2-60-Sparrow1","unstructured":"Sparrow, S. S., \n \n Cicchetti, D. V., & Balla, D. A. (2005). Vineland-II: Vineland Adaptive Behavior Scale (2nd ed.). Circle Pines, MN: American Guidance Services."},{"key":"2021030812302027100_i2159-4341-17-2-60-Starr1","first-page":"315","article-title":"How are schools doing? Parental perceptions of children with autism spectrum disorders, Down syndrome and learning disabilities: A comparative analysis","volume":"41","author":"Starr","year":"2006","journal-title":"Education and Training in Developmental Disabilities"},{"key":"2021030812302027100_i2159-4341-17-2-60-Symes1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1471\u20133802.2011.01196.x","article-title":"School factors that facilitate or hinder the ability of teaching assistants to effectively support pupils with autism spectrum disorders (ASDs) in mainstream secondary schools","volume":"11","author":"Symes","year":"2011","journal-title":"Journal of Research in Special Educational Needs"},{"key":"2021030812302027100_i2159-4341-17-2-60-Symes2","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1080\/08856257.2012.726019","article-title":"Including pupils with autistic spectrum disorders in the classroom: The role of teaching assistants","volume":"27","author":"Symes","year":"2012","journal-title":"European Journal of Special Needs Education"},{"key":"2021030812302027100_i2159-4341-17-2-60-Wechsler1","unstructured":"Wechsler, D. \n (2003). Wechsler Intelligence Scale for Children, 4th edn. (WISC- IV). San Antonio, TX: The Psychological Corporation."},{"key":"2021030812302027100_i2159-4341-17-2-60-Whitaker1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/j.1467\u20138578.2007.00473.x","article-title":"Provision for youngsters with autistic spectrum disorders in mainstream schools: What parents say - and what parents want","volume":"34","author":"Whitaker","year":"2007","journal-title":"British Journal of Special Education"},{"key":"2021030812302027100_i2159-4341-17-2-60-Williams1","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1111\/j.1440\u20131754.2008.01331.x","article-title":"The prevalence of autism in Australia. Can it be established from existing data?","volume":"44","author":"Williams","year":"2008","journal-title":"Journal of Paediatrics and Child Health"}],"container-title":["Journal of International Special Needs Education"],"language":"en","link":[{"URL":"http:\/\/meridian.allenpress.com\/jisne\/article-pdf\/17\/2\/60\/2276119\/2159-4341-17_2_60.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/meridian.allenpress.com\/jisne\/article-pdf\/17\/2\/60\/2276119\/2159-4341-17_2_60.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T20:17:15Z","timestamp":1753129035000},"score":7.555926,"resource":{"primary":{"URL":"https:\/\/jisne.kglmeridian.com\/view\/journals\/spne\/17\/2\/article-p60.xml"}},"issued":{"date-parts":[[2014,11,1]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,11,1]]}},"URL":"https:\/\/doi.org\/10.9782\/2159-4341-17.2.60","ISSN":["2159-4341","2331-4001"],"issn-type":[{"value":"2159-4341","type":"print"},{"value":"2331-4001","type":"electronic"}],"published":{"date-parts":[[2014,11,1]]}},{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:21:32Z","timestamp":1762899692110,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006065","name":"Health Department of Western Australia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australian J Rural Health"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Abstract<\/jats:title>Problem<\/jats:title>Despite acknowledged benefits, the impact of advance care planning on usual care is inconsistent.<\/jats:p><\/jats:sec>Design<\/jats:title>Quality improvement study.<\/jats:p><\/jats:sec>Setting<\/jats:title>A Western Australian regional hospital.<\/jats:p><\/jats:sec>Key measures for improvement<\/jats:title>This project aimed to create a system for storing, accessing and incorporating advance care planning documents in clinical care.<\/jats:p><\/jats:sec>Strategies for change<\/jats:title>Interventions over 18 months addressed four areas: medical records processes for receiving and processing advance care planning documents; information technology solutions for electronic storage and alerts; clerical staff duties in regards advance care planning documents; and clinician education.<\/jats:p><\/jats:sec>Effects of change<\/jats:title>There was a 12\u2010fold increase in advance care planning documents stored electronically and 100% of audited notes had correct filing of advance care planning documents with an alert in place at follow\u2010up audit. Clinician recognition of the presence of an advance care planning document improved. Detailed examples of interventions are described.<\/jats:p><\/jats:sec>Lessons learnt<\/jats:title>Repeated exposure to different forms of advance care planning education, in conjunction with simple but effective system changes can make a difference in changing established hospital practice. Final impact of these changes on end\u2010of\u2010life care requires further audit.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajr.12467","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T12:25:07Z","timestamp":1548851107000},"page":"104-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Project to improve storage, access and incorporation of advance care plans in a regional Australian hospital"],"prefix":"10.1111","volume":"27","author":[{"given":"Kirsten","family":"Auret","sequence":"first","affiliation":[{"name":"University of Western Australia Albany Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Sinclair","sequence":"additional","affiliation":[{"name":"University of Western Australia Albany Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Edith Cowan University Joondalup Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Thomas","sequence":"additional","affiliation":[{"name":"University of Western Australia Albany Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dot","family":"Price","sequence":"additional","affiliation":[{"name":"District Health Advisory Committee Western Australian Country Health Service Albany Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,30]]},"reference":[{"volume-title":"ANZICS Statement on Care and Decision\u2010Making at the End of Life for the Critically Ill (Edition 1.0)","year":"2014","author":"Australian and New Zealand Intensive Care Society","key":"e_1_2_10_2_1"},{"volume-title":"National Consensus Statement: Essential Elements for Safe and High\u2010Quality End\u2010of\u2010Life Care","year":"2015","author":"Australian Commission on Safety and Quality in Health Care","key":"e_1_2_10_3_1"},{"volume-title":"EQuIP National Guidelines. Standard 12. Provision of Care","year":"2012","author":"Australian Council on Healthcare Standards","key":"e_1_2_10_4_1"},{"key":"e_1_2_10_5_1","unstructured":"Commonwealth of Australia.Advance Care Directives 2011 National Framework. The Clinical Technical and Ethical. Principle Committee of the Australian Health Ministers\u2019 Advisory Council. Australian Health Ministers\u2019 Advisory Council;2011."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja13.10158"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269216314526272"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1345"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1071\/AH14119"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.6055"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1071\/AH14118"},{"key":"e_1_2_10_12_1","unstructured":"Institute for Healthcare Improvement.A public engagement campaign advocating \u201ckitchen table\u201d conversations with family and friends about wishes for end\u2010of\u2010life care. [Cited 20 Apr 2016]. Available from URL:http:\/\/www.ihi.org\/engage\/initiatives\/ConversationProject\/Pages\/default.aspx"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12549"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajr.12167"},{"volume-title":"Easy Guide to Clinical Practice Improvement: A Guide for Healthcare Professionals","year":"2002","author":"New South Wales Department of Health","key":"e_1_2_10_15_1"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs-2013-001862"},{"key":"e_1_2_10_17_1","unstructured":"Government of Western Australia Department of Health.Advance Health Directives \u2013 training and resources. [Cited 22 Apr 2016]. Available from URL:http:\/\/ww2.health.wa.gov.au\/Articles\/A_E\/Advance-Health-Directives-training-and-resources"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2753.2010.01518.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2015.12.318"}],"container-title":["Australian Journal of Rural Health"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajr.12467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajr.12467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T20:45:45Z","timestamp":1694724345000},"score":7.5557866,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajr.12467"}},"issued":{"date-parts":[[2019,1,30]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/ajr.12467"],"URL":"https:\/\/doi.org\/10.1111\/ajr.12467","archive":["Portico"],"ISSN":["1038-5282","1440-1584"],"issn-type":[{"type":"print","value":"1038-5282"},{"type":"electronic","value":"1440-1584"}],"published":{"date-parts":[[2019,1,30]]},"assertion":[{"value":"2018-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T18:07:57Z","timestamp":1779473277818,"version":"3.53.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:00:00Z","timestamp":1757116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:00:00Z","timestamp":1757116800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Antimicrobial resistance (AMR) poses a critical public health issue, exacerbated by the overuse and misuse of antibiotics. Children are particularly susceptible to bacterial infections and are frequently prescribed antibiotics.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study examined trends in antibiotic dispensing to children aged under 13\u2009years in Australia between 2013 and 2023.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective observational study used a 10% random sample of dispensing records for nationally subsidised prescription antibiotics. The number of children dispensed an antibiotic was calculated for each year and expressed per 100 children. Trends were analysed using joinpoint regression overall and by age group, sex, the World Health Organisation's Access, Watch, Reserve (AWaRe) system of antibiotic classification and antibiotic subtype.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Between 2013 and 2023, 3,406,208 antibiotic prescriptions were dispensed to 554,837 children. There was a decrease in the total number of antibiotic prescriptions dispensed, falling from 103 prescriptions dispensed for every 100 children in 2013 to 63 prescriptions in 2023 (annual percent change [APC]: \u22126.9, 95% CI: \u22129.8, \u22124.4). While decreases were observed for medications classified as \u2018Access\u2019 (APC: \u22125.8, 95% CI: \u22128.7, \u22123.1), the largest decrease was observed in \u2018Watch\u2019 medications (APC: \u221215.0, 95% CI: \u221219.4, \u221211.7). Decreases were observed in the proportion of children dispensed an antibiotic, declining from 45.7% in 2013 to 33.6% in 2023 (APC: \u22124.7%, 95% CI: \u22127.1%, \u22122.5%). Reductions in dispensing were observed overall and by sex, age groups and most antibiotic types.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Antibiotic dispensing in Australian children has decreased over the past decade, for all ages, sexes and antibiotic sub\u2010classes, likely reflecting implemented policies and efforts to curb overuse of antibiotic medicines and AMR during this period.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ppe.70068","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T11:29:07Z","timestamp":1757158147000},"page":"342-348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Changes in the Dispensing of Antibiotics to Australian Children Between 2013 and 2023: Are We Heading in the Right Direction?"],"prefix":"10.1111","volume":"40","author":[{"given":"Erin","family":"Kelty","sequence":"first","affiliation":[{"name":"School of Population and Global Health The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Tairy","sequence":"additional","affiliation":[{"name":"School of Population and Global Health The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Sims","sequence":"additional","affiliation":[{"name":"School of Population and Global Health The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5053-3516","authenticated-orcid":false,"given":"Carol","family":"Orr","sequence":"additional","affiliation":[{"name":"School of Population and Global Health The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Page","sequence":"additional","affiliation":[{"name":"School of Allied Health The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Preen","sequence":"additional","affiliation":[{"name":"School of Population and Global Health The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M.","family":"Sanfilippo","sequence":"additional","affiliation":[{"name":"School of Population and Global Health The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Etherton\u2010Beer","sequence":"additional","affiliation":[{"name":"Medical School The University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebony","family":"Quintrell","sequence":"additional","affiliation":[{"name":"School of Population and Global Health The University of Western Australia Crawley Western Australia Australia"},{"name":"Wal\u2010yan Respiratory Research Centre The Kids Research Institute Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01867-1"},{"key":"e_1_2_10_3_1","unstructured":"Australian Government \u201cAntimicrobial Resistance [Internet] \u201d [updated November 14 2022; cited March 17 2024] 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to the Threat of Antimicrobial Resistance: Australia's First National Antimicrobial Resistance Strategy 2015\u20132019","author":"Anon","year":"2015"},{"key":"e_1_2_10_21_1","volume-title":"Australia's National Antimicrobial Resistence Strategy\u20142020 & Beyond","author":"Anon","year":"2019"},{"key":"e_1_2_10_22_1","unstructured":"\u201cTherapeutic Guidelines [Internet] \u201d [updated September 2021; cited March 17 2024] https:\/\/www.tg.org.au\/the\u2010organisation\/guideline\u2010development\/."},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1071\/AH16238"},{"key":"e_1_2_10_24_1","volume-title":"Fifth Australian Report on Antimicrobial Use and Resistance in Human Health","author":"AURA ACoSaQiHC","year":"2023"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3756"},{"key":"e_1_2_10_26_1","unstructured":"Statistics ABo \u201cNational State and Territory Population 2024 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(2021)."}],"container-title":["Paediatric and Perinatal 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First\u2010 and later\u2010born children have been linked to an increased likelihood of an Autism Spectrum Disorder (ASD) diagnosis, with a smaller body of evidence implicating decreases in cognitive functioning with increased birth order. The present study investigated the potential association between birth order and ASD diagnostic phenotypes in a large and representative population sample.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Data were obtained from an ongoing prospective diagnostic registry, collected between 1999 and 2017, including children (1\u201318\u00a0years of age,\n n<\/jats:italic>\n \u00a0=\u00a05,404) diagnosed with ASD in the state of Western Australia. Children with ASD were ranked relative to sibling\u2019s birth to establish birth order within families at time of ASD diagnosis. Information reported to the registry by health professionals at the time of diagnostic evaluation included demographic and family characteristics, functional abilities and intellectual capacity.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Adaptive functioning and intelligence scores decreased with increasing birth order, with later\u2010born children more likely to have an intellectual disability. Compared to first\u2010born children with siblings, first\u2010born children without siblings at the time of diagnosis also exhibited decreased cognitive functioning.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n These findings demonstrate for the first time an association between increasing birth order and variability in ASD clinical phenotypes at diagnosis, with potential evidence of reproductive curtailment in children without siblings. Taken together, these findings have significant implications for advancing understanding about the potential mechanisms that contribute to heterogeneity in ASD clinical presentations as a function of birth order and family size.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jcpp.13349","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T02:25:24Z","timestamp":1604888724000},"page":"961-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Investigating associations between birth order and autism diagnostic phenotypes"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-5919","authenticated-orcid":false,"given":"Gail A.","family":"Alvares","sequence":"first","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3705-5323","authenticated-orcid":false,"given":"Melissa K.","family":"Licari","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-0573","authenticated-orcid":false,"given":"Keely","family":"Bebbington","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1139-3682","authenticated-orcid":false,"given":"Matthew N.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma J.","family":"Glasson","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-8435","authenticated-orcid":false,"given":"Diana W.","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Psychological Science The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7481-3923","authenticated-orcid":false,"given":"Mirko","family":"Uljarevi\u0107","sequence":"additional","affiliation":[{"name":"Melbourne School of Psychological Sciences Faculty of Medicine, Dentistry, and Health Sciences University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kandice J.","family":"Varcin","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7549-6678","authenticated-orcid":false,"given":"John","family":"Wray","sequence":"additional","affiliation":[{"name":"Child and Adolescent Health Service Western Australia Department of Health Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8722-1575","authenticated-orcid":false,"given":"Andrew J. 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Psychiatry"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpp.13349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpp.13349","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111\/jcpp.13349","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpp.13349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T11:40:09Z","timestamp":1762170009000},"score":7.5556273,"resource":{"primary":{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/10.1111\/jcpp.13349"}},"issued":{"date-parts":[[2020,11,8]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/jcpp.13349"],"URL":"https:\/\/doi.org\/10.1111\/jcpp.13349","archive":["Portico"],"ISSN":["0021-9630","1469-7610"],"issn-type":[{"value":"0021-9630","type":"print"},{"value":"1469-7610","type":"electronic"}],"published":{"date-parts":[[2020,11,8]]},"assertion":[{"value":"2020-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication 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This study sought to examine the intracranial (IC) and extracranial (EC) patterns of response and progression in patients with active melanoma brain metastases treated with dabrafenib.<\/jats:p><\/jats:sec>METHODS<\/jats:title>Clinicopathologic parameters were collected on patients with active brain metastases enrolled in the phase 1 and 2 studies of dabrafenib at a single institution. RECIST (Response Evaluation Criteria In Solid Tumors) response and progression\u2010free survival (PFS) were prospectively assessed by disease site (IC versus EC). Treatments received after disease progression were also assessed.<\/jats:p><\/jats:sec>RESULTS<\/jats:title>A total of 23 patients were studied. Response rates were similar in IC (78%) and EC (90%) sites (P<\/jats:italic>\u2009=\u2009.416). IC and EC response was concordant in 71% of patients. Median site\u2010specific PFS was identical in both IC and EC sites (23.6 weeks, P<\/jats:italic>\u2009=\u2009.465), and exceeded whole\u2010body PFS determined by RECIST (16.3 weeks). Of 20 patients with progressive disease (PD), 6 had IC PD only, 6 had EC PD only, and 8 had PD in both sites. In those with isolated intracranial PD, 5 of 6 underwent local therapy to the brain and continued on dabrafenib longer than 30 days.<\/jats:p><\/jats:sec>CONCLUSIONS<\/jats:title>IC and EC melanoma metastases respond similarly to dabrafenib. There is no dominant site or pattern of disease progression in patients with brain metastases treated with dabrafenib. Salvage local therapy is possible in most patients after IC disease progression, with ongoing dabrafenib treatment possible in a subset of patients. Cancer<\/jats:italic> 2014;120:530\u2013536<\/jats:bold>. \u00a9 2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.28445","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T15:48:53Z","timestamp":1383666533000},"page":"530-536","source":"Crossref","is-referenced-by-count":37,"title":["Patterns of response and progression in patients with BRAF<\/i>\u2010mutant melanoma metastatic to the brain who were treated with dabrafenib"],"prefix":"10.1002","volume":"120","author":[{"given":"Mary W. F .","family":"Azer","sequence":"first","affiliation":[{"name":"Westmead Hospital Westmead Australia"},{"name":"Melanoma Institute Australia Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander M.","family":"Menzies","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia Sydney Australia"},{"name":"The University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren E.","family":"Haydu","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia Sydney Australia"},{"name":"The University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard F.","family":"Kefford","sequence":"additional","affiliation":[{"name":"Westmead Hospital Westmead Australia"},{"name":"Melanoma Institute Australia Sydney Australia"},{"name":"The University of Sydney Sydney Australia"},{"name":"Westmead Institute for Cancer Research Westmead 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pilot study of vemurafenib in previously treated metastatic melanoma (mM) patients (pts) with symptomatic brain metastases (BM) [abstract]","volume":"23","author":"Dummer R","year":"2012","journal-title":"Ann Oncol."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.3.205"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.8691"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60868-X"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs353"},{"key":"e_1_2_7_18_1","first-page":"721","article-title":"Outcomes of patients with malignant melanoma treated with immunotherapy prior to or after BRAF targeted inhibitors [abstract]","volume":"35","author":"Ackerman A","year":"2012","journal-title":"J 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Australian data are inconsistent, limited in scope and have not considered cost.<\/jats:p><\/jats:sec>Aims<\/jats:title>To evaluate the prevalence, associates and costs of CM in a contemporary Australian urban, community\u2010based cohort of people with type 2 diabetes.<\/jats:p><\/jats:sec>Methods<\/jats:title>Baseline CM use was determined as part of a detailed assessment in 1543 of 1551 Fremantle Diabetes Study Phase II (FDS2) participants with type 2 diabetes (mean age 65.7 years, 51.8% males, median diabetes duration 9.0 years) recruited to the FDS2 between 2008 and 2011 who self\u2010reported medication use including CM defined as non\u2010prescription medicinal products.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 672 FDS2 type 2 participants (43.6%) used at least one type of CM, 92% of which were nutritional supplements (omega\u20103 fatty acids\/fish oil in 24% of CM users followed by calcium in 11%, glucosamine in 10% and others in <10%). Independent associates of CM use included older age, female sex, any mobility problem, and, inversely, Southern European or Indigenous Australian background, lack of English fluency, ex\/current smoking status, taking oral glucose\u2010lowering medications and higher HbA1c<\/jats:sub>. The total annual estimated cost of CM used by FDS2 participants with type 2 diabetes was A$121\u2009640 or A$79 \u00b1 208 per person (range A$0\u20132993). Extrapolating these data, the 1 million Australians with type 2 diabetes spend A$79 million\/year on CM.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>CM use in type 2 diabetes is both common and costly. Healthcare professionals should consider discussing safe and cost\u2010effective use of CM with their patients with type 2 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.14437","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T15:22:56Z","timestamp":1563376976000},"page":"944-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Complementary medicine use and its cost in Australians with type 2 diabetes: the Fremantle Diabetes Study Phase II"],"prefix":"10.1111","volume":"50","author":[{"given":"Tatsiana","family":"Yarash","sequence":"first","affiliation":[{"name":"School of Allied Health University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imrana","family":"Sharif","sequence":"additional","affiliation":[{"name":"School of Allied Health University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhat","family":"Masood","sequence":"additional","affiliation":[{"name":"School of Allied Health University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda M.","family":"Clifford","sequence":"additional","affiliation":[{"name":"School of Allied Health University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5709-8235","authenticated-orcid":false,"given":"Wendy A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Medical School University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-7411","authenticated-orcid":false,"given":"Timothy M. 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CAMELOT phase II: surveying for diversity","volume":"24","author":"Manderson L","year":"2012","journal-title":"Aust J Herbal Med"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/jcim-2014-0038"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jppr2003334260"},{"key":"e_1_2_7_11_1","unstructured":"Therapeutic Goods Administration. An overview of the regulation of complementary medicines in Australia.2017[cited 2019 Apr]. Available from URL:http:\/\/www.tga.gov.au\/industry\/cm-basics-regulation-overview.htm"},{"key":"e_1_2_7_12_1","unstructured":"US National Center for Complementary and Integrative Health US Department of Health and Human Services. Complementary alternative or integrative health: what's in a name? 2019 [cited 2019 Apr]. Available from URL:https:\/\/nccih.nih.gov\/health\/integrative-health"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177307"},{"key":"e_1_2_7_14_1","first-page":"570","article-title":"Current issues regarding complementary and alternative medicine (CAM) in the United States: part 3: policies and practices regarding dietary supplements in health care facilities","volume":"35","author":"Ventola CL","year":"2010","journal-title":"P T"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/cd18-0105"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310799"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys065"},{"key":"e_1_2_7_18_1","unstructured":"Australian Bureau of Statistics. Socio\u2010economic indexes for areas.2013[cited 2019 Jun]. Available from URL:http:\/\/www.abs.gov.au\/websitedbs\/censushome.nsf\/home\/seifa"},{"key":"e_1_2_7_19_1","unstructured":"Chemist Warehouse. Chemist Warehouse home page.2017[cited 2019 Apr]. Available from URL:https:\/\/www.chemistwarehouse.com.au\/"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2015.06.011"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/45.4.516"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-7-217"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2015.07.003"},{"key":"e_1_2_7_24_1","first-page":"216","article-title":"Herbs, prayer, and insulin. Use of medical and alternative treatments by a group of Mexican American diabetes patients","volume":"49","author":"Hunt LM","year":"2000","journal-title":"J Fam Pract"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-019-0590-x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-018-1247-3"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812792"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1586\/17512433.2016.1171712"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2006.01014.x"}],"container-title":["Internal Medicine Journal"],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.14437","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.14437","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.14437","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.14437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T03:23:43Z","timestamp":1693884223000},"score":7.5554895,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.14437"}},"issued":{"date-parts":[[2020,8]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/imj.14437"],"URL":"https:\/\/doi.org\/10.1111\/imj.14437","archive":["Portico"],"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"2019-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T17:40:13Z","timestamp":1756662013799,"version":"3.44.0"},"reference-count":21,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"unspecified","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031198","name":"Department of Health Western Australia","doi-asserted-by":"crossref","award":["Research Translation Project grant"],"award-info":[{"award-number":["Research Translation Project grant"]}],"id":[{"id":"10.13039\/100031198","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Resp Res"],"accepted":{"date-parts":[[2020,2,10]]},"published-print":{"date-parts":[[2020,3]]},"abstract":"\n Introduction<\/jats:title>\n Pulmonary rehabilitation is a core component of the treatment of people with chronic obstructive pulmonary disease (COPD); however, the benefits gained diminish in the ensuing months. The optimal strategy for maintaining the benefits is unclear with weekly supervised maintenance exercise programmes proposed as one strategy. However, the long-term future of maintenance programs is dependent on quality evidence.<\/jats:p>\n <\/jats:sec>\n \n Methods and analysis<\/jats:title>\n The ComEx3 randomised controlled trial will investigate the efficacy of extending a weekly supervised maintenance programme for an additional 6 months following an initial 10-week maintenance programme (intervention) by comparing with a control group who receive the same 10-week maintenance programme followed by 6 months of usual care. 120 participants with COPD will be recruited. Primary objective is to determine health-related quality of life over 12 months. Secondary objectives are to determine functional exercise capacity trajectory and to perform an economic evaluation of the intervention to the health system. Outcomes will be analysed for superiority according to intention-to-treat and per-protocol approaches.<\/jats:p>\n <\/jats:sec>\n \n Ethics and dissemination<\/jats:title>\n Approval has been received from the relevant ethics committees. Findings will be disseminated in peer-reviewed journals and conferences, targeting those involved in managing people with COPD as well as those who develop policies and guidelines.<\/jats:p>\n <\/jats:sec>\n \n Clinical trial registration<\/jats:title>\n ANZCTR 12618000933257<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjresp-2019-000548","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T15:44:26Z","timestamp":1585064666000},"page":"e000548","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Maintaining quality of life in patients with chronic obstructive pulmonary disease (COPD) by extending the maintenance phase of community-based pulmonary rehabilitation: protocol for a randomised controlled trial (ComEx3 Study)"],"prefix":"10.1136","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0677-0420","authenticated-orcid":false,"given":"Derrick","family":"Lopez","sequence":"first","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nola","family":"Cecins","sequence":"additional","affiliation":[{"name":"Physiotherapy Department, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Cockram","sequence":"additional","affiliation":[{"name":"Community Physiotherapy Services, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Collins","sequence":"additional","affiliation":[{"name":"Community Physiotherapy Services, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly","family":"Landers","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Joondalup Health Campus, Joondalup, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Sanfilippo","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Briffa","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fraser","family":"Brims","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"},{"name":"Medical School, Curtin University, Perth, Western Australia, Australia"},{"name":"Institute for Respiratory Health, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Geelhoed","sequence":"additional","affiliation":[{"name":"School of Allied Health, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Murray","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Phillips","sequence":"additional","affiliation":[{"name":"Lung Foundation Australia, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Preen","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Jenkins","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Physiotherapy Department, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"},{"name":"Institute for Respiratory Health, Perth, Western Australia, Australia"},{"name":"School of Physiotherapy and Exercise Science, Curtin University, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,3,24]]},"reference":[{"key":"2025083110241577000_7.1.e000548.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201309-1634ST"},{"key":"2025083110241577000_7.1.e000548.2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1071\/AH080415","article-title":"Reduction in hospitalisation following pulmonary rehabilitation in patients with COPD","volume":"32","author":"Cecins","year":"2008","journal-title":"Aust Health Review"},{"key":"2025083110241577000_7.1.e000548.3","doi-asserted-by":"crossref","unstructured":"McCarthy B , Casey D , Devane D , et al . Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2015:CD003793.doi:10.1002\/14651858.CD003793.pub3","DOI":"10.1002\/14651858.CD003793.pub3"},{"key":"2025083110241577000_7.1.e000548.4","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/resp.13025","article-title":"Australian and New Zealand pulmonary rehabilitation guidelines","volume":"22","author":"Alison","year":"2017","journal-title":"Respirology"},{"key":"2025083110241577000_7.1.e000548.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2010.01849.x"},{"key":"2025083110241577000_7.1.e000548.6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2421"},{"key":"2025083110241577000_7.1.e000548.7","first-page":"257","article-title":"Efficacy of supervised maintenance exercise following pulmonary rehabilitation on health care use: a systematic review and meta-analysis","volume":"13","author":"Jenkins","year":"2018","journal-title":"Int J Chronic 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Five chickpea accessions contrasting in P\u2010remobilisation efficiency (PRE) were grown in a temperature\u2010controlled glasshouse under moderate P deficiency. Root P\u2010acquisition traits (rhizosheath carboxylates and rhizosheath acid phosphatase activity) and leaf P\u2010use traits (PRE, photosynthetic P\u2010use efficiency (PPUE), P fractions, and leaf acid phosphatase activity) were measured. Phosphorus acquisition substantially increased during reproduction compared with the vegetative stage, with greater carboxylates recovered from the rhizosheath and higher rhizosheath acid phosphatase activity. Root nitrogen (N) and P concentrations increased by 108% and 54%, respectively. Leaf PRE increased by 28%, with higher resorption efficiency across most P fractions, whereas N\u2010resorption efficiency was stable. Although area\u2010based photosynthetic rate increased by 34%, PPUE did not, and we observed no trade\u2010off between PPUE and PRE. Leaf thickness and leaf mass per area increased by 22% and 34%, respectively, partially explaining the faster photosynthetic rate. Concurrent we also observed increases in transpiration, and this may be associated with increased photosynthetic capacity. These results reveal coordinated increases in root P acquisition and leaf P remobilisation during reproduction, likely driven by stronger sink demand.<\/jats:p>","DOI":"10.1111\/pce.70797","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T04:34:47Z","timestamp":1786336487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Concurrent Increases in Root Phosphorus Acquisition and Leaf Phosphorus Resorption Underpin Enhanced Phosphorus Economy in Chickpea During Reproductive Development"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8997-8763","authenticated-orcid":false,"given":"Xiaolong","family":"Feng","sequence":"first","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"The UWA Institute of Agriculture The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7139-2693","authenticated-orcid":false,"given":"Shuyan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"The UWA Institute of Agriculture The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8127-645X","authenticated-orcid":false,"given":"Jiayin","family":"Pang","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"The UWA Institute of Agriculture The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5188-4737","authenticated-orcid":false,"given":"Peta L.","family":"Clode","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"Centre for Microscopy, Characterisation and Analysis The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4118-2272","authenticated-orcid":false,"given":"Hans","family":"Lambers","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Western Australia Perth Western Australia Australia"},{"name":"The UWA Institute of Agriculture The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6097-4235","authenticated-orcid":false,"given":"Kadambot H. 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The decision has an impact on a person's autonomy and human rights. Conversely, the decision to admit may facilitate urgent assessment and treatment and ensure the safety of the individual and others. Research highlights that decision\u2010making in this context is challenging due to the multiple information sources and often incomplete information available to the clinician. Situation awareness is a concept used to explain how practitioners identify, use and make meaning of a multitude of factors and elements relevant to their practice.<\/jats:p><\/jats:sec>Design<\/jats:title>Discussion paper.<\/jats:p><\/jats:sec>Data sources<\/jats:title>A search of terms related to situation awareness and mental health nursing was conducted in the period 2000 \u2013 present.<\/jats:p><\/jats:sec>Implications for nursing<\/jats:title>Exploring nurses decision\u2010making using a situation awareness framework provides for a more nuanced understanding of nurses knowledge and skill when deciding to admit or not a person as an involuntary patient.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The concept of situation awareness provides a framework to better understand the decision\u2010making process associated with the involuntary admission decision.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jan.13024","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T16:14:01Z","timestamp":1463847241000},"page":"2042-2053","source":"Crossref","is-referenced-by-count":13,"title":["Situation awareness: when nurses decide to admit or not admit a person with mental illness as an involuntary patient"],"prefix":"10.1111","volume":"72","author":[{"given":"Christopher","family":"Patterson","sequence":"first","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Procter","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Toffoli","sequence":"additional","affiliation":[{"name":"University of South Australia Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/ps.46.7.727"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065514"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1071181311551177"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijhcs.2003.12.012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nedt.2013.09.015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jen.2010.07.023"},{"key":"e_1_2_10_8_1","unstructured":"California Welfare and Institutions Code \u2013 Section\u00a05150\u20105155(California USA). 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Included here are high risk neuroblastomas, Diffuse Intrinsic Pontine Gliomas (DIPG), and infant leukemias with MLL translocations. New treatments for these aggressive childhood cancers are urgently needed. Evidence is emerging of the importance of alterations in chromatin modifier genes in pediatric cancers. In this regard, CBL0137 is a carbazole-based anti-cancer agent with a unique mechanism of action. It is an indirect inhibitor of the chromatin remodeling complex FACT (Facilitates Chromatin Transcription). Inhibition of FACT by CBL0137 modulates the activity of several transcription factors involved in cancer: NF-kB and HSF1 are suppressed, while p53 is activated (Science Transl Med, 2011). We have examined FACT expression in neuroblastoma, DIPG and MLL leukemia, as well as the efficacy of CBL0137 in preclinical models of these diseases.<\/jats:p>\n Methods: Expression of the FACT subunits, SSRP1 and SPT16, was examined in neuroblastoma, DIPG and MLL leukemia cells using RT-PCR and Western analysis. The clinical significance of SSRP1 and SPT16 was also analysed using expression array data on 650 primary untreated neuroblastomas. Colony-forming assays were used to study the effect of CBL0137, either alone or combined with chemotherapeutic drugs. Cohorts of neuroblastoma, DIPG and MLL leukemia xenografted mice, as well as neuroblastoma-prone TH-MYCN mice, were treated with CBL0137, alone or combined with chemotherapeutic drugs.<\/jats:p>\n Results: High levels of SSRP1 and SPT16 expression were observed in all three types of child cancer. In addition, in neuroblastoma, the two FACT subunits were associated with MYCN amplification, and were strongly predictive of poor outcome (p&lt;0.0001). As a single agent, CBL0137 administered iv had remarkable in vivo anti-tumor activity against neuroblastoma, DIPG and MLL leukemia xenografted mice. CBL0137 also synergized strongly with a variety of chemotherapeutic agents, including cyclophosphamide. Most dramatic results were observed when CBL0137 was combined with cyclophosphamide\/topotecan, a highly active therapy for relapsed neuroblastoma that is currently in clinical trial. Cylophosphamide\/topotecan plus CBL0137 resulted in cure of 90% of tumor-bearing MYCN-transgenic mice.<\/jats:p>\n Conclusions: Targeting FACT offers a highly promising novel therapeutic approach for aggressive childhood cancers. The results for CBL0137 are as good or better than any chemotherapy regimens we have tested in our preclinical models, and a Phase I COG trial of this nongenotoxic agent in refractory pediatric cancer patients is currently being planned.<\/jats:p>\n Citation Format: Michelle Haber, Jayne Murray, Laura Gamble, Ashleigh Carnegie-Clark, Hannah Webber, Michelle Ruhle, Michelle J. Henderson, Shiloh Middlemass, Daniel Carter, Maria Tsoli, Anahid Ehteda, Sandy Simon, Andre Oberthuer, Matthias Fischer, Katerina Gurova, Catherine Burkhart, Andrei Purmal, Richard B. Lock, David Ziegler, Glenn M. Marshall, Andrei V. Gudkov, Murray D. Norris. The FACT histone chaperone complex is highly expressed in aggressive drug refractory childhood cancers and the anti-FACT compound CBL0137 represents a highly promising therapeutic approach in this setting. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1611. doi:10.1158\/1538-7445.AM2015-1611<\/jats:p>","DOI":"10.1158\/1538-7445.am2015-1611","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T01:32:04Z","timestamp":1438738324000},"page":"1611-1611","update-policy":"http:\/\/dx.doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 1611: The FACT histone chaperone complex is highly expressed in aggressive drug refractory childhood cancers and the anti-FACT compound CBL0137 represents a highly promising therapeutic approach in this setting"],"prefix":"10.1158","volume":"75","author":[{"given":"Michelle","family":"Haber","sequence":"first","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayne","family":"Murray","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gamble","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashleigh","family":"Carnegie-Clark","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Webber","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Ruhle","sequence":"additional","affiliation":[{"name":"1Children's Cancer Institute Australia, Sydney, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle J.","family":"Henderson","sequence":"additional","affiliation":[{"name":"1Children's Cancer 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Biotechnology Journal"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Summary<\/jats:title>Future genetic improvement of sugarcane depends, in part, on the ability to produce high\u2010yielding transgenic cultivars with improved traits such as herbicide and insect resistance. Here, transgenic sugarcane plants generated by different transformation methods were assessed for field performance over 3\u00a0years. A<\/jats:styled-content>grobacterium<\/jats:italic>\u2010mediated (Agro) transgenic events (35) were produced using four different A<\/jats:styled-content>grobacterium tumefaciens<\/jats:italic> strains, while biolistic (Biol) transgenic events (48) were produced using either minimal linearized DNA<\/jats:styled-content> (LDNA<\/jats:styled-content>) transgene cassettes with 5\u2032, 3\u2032 or blunt ends or whole circular plasmid (PDNA<\/jats:styled-content>) vectors containing the same transgenes. A combined analysis showed a reduction in growth and cane yield in Biol, Agro as well as untransformed tissue culture (TC<\/jats:styled-content>) events, compared with the parent clone (PC<\/jats:styled-content>) Q117 (no transformation or tissue culture) in the plant, first ratoon and second ratoon crops. However, when individual events were analysed separately, yields of some transgenic events from both Agro and Biol were comparable to PC<\/jats:styled-content>, suggesting that either transformation method can produce commercially suitable clones. Interestingly, a greater percentage of Biol transformants were similar to PC<\/jats:styled-content> for growth and yield than Agro clones. Crop ratoonability and sugar yield components (Brix%, Pol%, and commercial cane sugar (CCS<\/jats:styled-content>)) were unaffected by transformation or tissue culture. Transgene expression remained stable over different crop cycles and increased with plant maturity. Transgene copy number did not influence transgene expression, and both transformation methods produced low transgene copy number events. No consistent pattern of genetic changes was detected in the test population using three DNA<\/jats:styled-content> fingerprinting techniques.<\/jats:p>","DOI":"10.1111\/pbi.12148","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T09:49:33Z","timestamp":1386841773000},"page":"411-424","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Field performance of transgenic sugarcane produced using Agrobacterium<\/i> and biolistics methods"],"prefix":"10.1111","volume":"12","author":[{"given":"Priya","family":"Joyce","sequence":"first","affiliation":[{"name":"Sugar Research Australia Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Hermann","sequence":"additional","affiliation":[{"name":"Sugar Research Australia Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Sugar Research Australia Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quang","family":"Dinh","sequence":"additional","affiliation":[{"name":"Sugar Research Australia Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard","family":"Shumbe","sequence":"additional","affiliation":[{"name":"Sugar Research Australia Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash","family":"Lakshmanan","sequence":"additional","affiliation":[{"name":"Sugar Research Australia Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-02391-0_23"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11032-004-8001-y"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008900230144"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7652.2011.00655.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11627-008-9159-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.1992.00409.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2135\/cropsci2007.06.0370"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7652.2004.00086.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2135\/cropsci1995.0011183X003500030040x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0523.2004.01021.x"},{"key":"e_1_2_6_13_1","first-page":"1","volume-title":"BSES Internal Report","author":"Chapman L.S.","year":"1984"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7652.2006.00235.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009687511633"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00224156"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02174028"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2135\/cropsci1996.0011183X003600050047x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2135\/cropsci2004.0771"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fcr.2008.10.009"},{"key":"e_1_2_6_21_1","unstructured":"2011 R. 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The questions related to: clinic demographics, familiarity with appliances\/procedures to accelerate orthodontic treatment, the use of appliances\/procedures to accelerate orthodontic treatment, and satisfaction with the outcomes when employing these appliances\/procedures.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The response rate was 42.38%. Of the respondents, 26.6% used customised fixed appliances which provided satisfactory outcomes. A small proportion of the respondents routinely used adjunctive procedures to accelerate treatment: 3.5% (\n n<\/jats:italic>\n =6) corticotomies, 1.2% (\n n<\/jats:italic>\n =2) piezocision, and 1.2% (\n n<\/jats:italic>\n =2) intraoral vibrating devices.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Although a significant number of Australian orthodontists use customised fixed appliances to improve the efficiency of orthodontic treatment, the use of adjunctive procedures to accelerate tooth movement remains very low. Further research is needed to understand the possible limitations and restrictions surrounding this area of practice.<\/jats:p>\n <\/jats:sec>","DOI":"10.2478\/aoj-2024-0017","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T10:41:21Z","timestamp":1721212881000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Orthodontists\u2019 perception and attitude toward accelerated orthodontic treatments in Australia"],"prefix":"10.2478","volume":"40","author":[{"given":"Amir","family":"Hatami","sequence":"first","affiliation":[{"name":"Dental School, The University of Western Australia , Crawley , Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Naoum","sequence":"additional","affiliation":[{"name":"Dental School, The University of Western Australia , Crawley , Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Dental School, The University of Western Australia , Crawley , Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Razza","sequence":"additional","affiliation":[{"name":"Dental School, The University of Western Australia , Crawley , Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithran S.","family":"Goonewardene","sequence":"additional","affiliation":[{"name":"School of Dentistry, The University of Western Australia , Crawley , Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"2026042711002547680_j_aoj-2024-0017_ref_001","doi-asserted-by":"crossref","unstructured":"Taghavi Bayat J, Huggare J, Mohlin B, Akrami N. 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The purpose of this study was to systematically review all available evidence on LTLC after II and identify gaps in knowledge to guide the direction of future research. A scoping review was performed to synthesize all available evidence on LTLC after II, as guided by the question, \u201cWhat are the LTLC after II, in patients with or without a history of translaryngeal intubation and\/or tracheostomy?\u201d. MEDLINE, Web of Science, Ovid Embase, Cochrane Library, and Google Scholar were searched for publications on this topic. Of the 3567 citations screened, a total of 153 full-text articles were assessed for eligibility and 49 were included in the scoping review. The overall level of evidence was low, with case reports constituting 46.7% of all included human studies. The lesions were most frequently in the trachea (36.9%), followed by the glottis (34.7%) and subglottis (19.0%). LTLC occur in 4.8 to 6.5% of patients after II and these complications are under-recognized in burns patients. The risk factors for LTLC include high-grade II, elevated initial inflammatory responses, prolonged translaryngeal intubation, and a history of tracheostomy. The goal of management is to restore airway patency, preserve voice quality, and restore normal diet and swallow function. There is limited high-level evidence on LTLC, particularly with regards to long-term functional morbidity in voice and swallow. Large, prospective studies are required to address this gap in knowledge.<\/jats:p>","DOI":"10.1093\/jbcr\/irac058","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T20:54:12Z","timestamp":1651265652000},"page":"381-392","source":"Crossref","is-referenced-by-count":4,"title":["Long-Term Laryngotracheal Complications After Inhalation Injury: A Scoping Review"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4218-7323","authenticated-orcid":false,"given":"Emily","family":"Zhen","sequence":"first","affiliation":[{"name":"Department of Burns, Perth Children\u2019s Hospital , Nedlands, Western Australia , Australia"},{"name":"Department of Burns, Fiona Stanley Hospital , Murdoch, Western Australia , Australia"},{"name":"Division of Surgery, University of Western Australia , Crawley, Western Australia , Australia"},{"name":"Department of Otolaryngology, Head and Neck Surgery, Perth Children\u2019s Hospital , Nedlands, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Misso","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic surgery, Perth Children\u2019s Hospital , Nedlands, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Rea","sequence":"additional","affiliation":[{"name":"Department of Burns, Perth Children\u2019s Hospital , Nedlands, Western Australia , Australia"},{"name":"Department of Burns, Fiona Stanley Hospital , Murdoch, Western Australia , Australia"},{"name":"Division of Surgery, University of Western Australia , Crawley, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyan","family":"Vijayasekaran","sequence":"additional","affiliation":[{"name":"Division of Surgery, University of Western Australia , Crawley, Western Australia , Australia"},{"name":"Department of Otolaryngology, Head and Neck 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CD14 and CC16 each play a key role in biologically important inflammatory pathways and the gene of each has a functional promoter-region polymorphism.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n This study was designed to determine the influence of these polymorphisms on plasma levels of their products and clinical disease during acute asthma. We hypothesized that genotype-related differences in CD14 and CC16 production would be more marked during acute asthma and related to disease severity.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We studied 148 children on presentation with acute asthma and again in convalescence. CD14 C-159T and CC16 A38G genotypes were determined, and plasma levels of soluble CD14 (sCD14) and CC16 were measured at both times.<\/jats:p>\n <\/jats:sec>\n \n Measurements and Main Results<\/jats:title>\n During acute asthma, plasma sCD14 levels were higher for the whole group (p = 0.003), but increases were only in subjects with CD14 \u2212159TT (p = 0.003) and \u2212159CT (p = 0.004), and not in those with \u2212159CC. Plasma CC16 levels were also elevated acutely for the whole group (p = 0.013), but only in those with CC16 38GG (p = 0.043) and 38AG (p = 0.014), and not in those with CC16 38AA. Subjects with CD14 \u2212159CC and CC16 38AA were more likely to have moderate or severe acute asthma.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Plasma levels of sCD14 and CC16 were higher during acute asthma in the subjects. Those with CD14 \u2212159CC and CC16 38AA had no change in sCD14 and CC16 levels and more severe asthma.<\/jats:p>\n <\/jats:sec>","DOI":"10.1164\/rccm.200509-1367oc","type":"journal-article","created":{"date-parts":[[2005,12,30]],"date-time":"2005-12-30T20:13:58Z","timestamp":1135973638000},"page":"617-622","source":"Crossref","is-referenced-by-count":55,"title":["Acute Asthma in Children"],"prefix":"10.1093","volume":"173","author":[{"given":"Andrew C.","family":"Martin","sequence":"first","affiliation":[{"name":"School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid A.","family":"Laing","sequence":"additional","affiliation":[{"name":"School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, 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University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":47,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["ID: 1196900"],"award-info":[{"award-number":["ID: 1196900"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2024,7,21]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n This study aimed to investigate acamprosate and naltrexone dispensing patterns in Australia.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A 10% representative sample of medications subsidized by the Australian Pharmaceutical Benefits Scheme (PBS) was used to identify individuals who were dispensed naltrexone or acamprosate between January 2006 and December 2023. Data were used to examine concurrent dispensing, medication switching and treatment episode length, as well as changes in prevalence and incidence over time.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n During the study, we identified 22 745 individuals with a total of 117 548 dispensed prescriptions (45.3% naltrexone, 43.0% acamprosate, and 11.7% concurrent dispensing). Alcohol pharmacotherapy dispensing occurred in 1354 per 100 000 individuals. It is estimated that 2.9% of individuals with an alcohol use disorder in Australia are receiving a PBS-listed pharmacological treatment. For both pharmacotherapies, individuals were most likely to be male (60.0%) and 35\u201354\u00a0years of age (56.0%). Individuals were more likely to switch from acamprosate to naltrexone rather than the reverse. From 2006 and 2023, the number of prevalent individuals treated with an alcohol pharmacotherapy significantly increased, driven mainly the use of naltrexone, which more than doubled over the study period. Incident naltrexone-treated individuals were more likely to remain on treatment for the recommended minimum 3-month period compared to acamprosate treated individuals, although overall dispensing for at least 3\u00a0months was low (5.1%).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In Australia between 2006 and 2023, rates of naltrexone dispensing have substantially increased, while acamprosate dispensing showed minimal changes. However, the use of alcohol pharmacotherapies remains low compared with the likely prevalence of alcohol use disorders.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/alcalc\/agae063","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T04:55:21Z","timestamp":1725684921000},"source":"Crossref","is-referenced-by-count":7,"title":["Alcohol pharmacotherapy dispensing trends in Australia between 2006 and 2023"],"prefix":"10.1093","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3065-2857","authenticated-orcid":false,"given":"Ebony","family":"Quintrell","sequence":"first","affiliation":[{"name":"School of Population and Global Health, University of Western Australia , Nedlands 6009, Western Australia, Australia"},{"name":"Respiratory Environmental Health , Wal-Yan Respiratory Research Centre, The Kids Research Institute Australia, Nedlands 6009, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Page","sequence":"additional","affiliation":[{"name":"School of Allied Health, University of Western Australia , Crawley 6009, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Wyrwoll","sequence":"additional","affiliation":[{"name":"The Kids Research Institute Australia , Nedlands 6009, Western Australia, Australia"},{"name":"School of Human Sciences, University of Western Australia , Crawley 6009, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Larcombe","sequence":"additional","affiliation":[{"name":"Respiratory Environmental Health , Wal-Yan Respiratory Research Centre, The Kids Research Institute Australia, Nedlands 6009, Western Australia, Australia"},{"name":"Occupation , Environment and Safety, School of Population Health, , Bentley 6102, Western Australia, Australia"},{"name":"Curtin University , Environment and Safety, School of Population Health, , Bentley 6102, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B","family":"Preen","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, University of Western Australia , Nedlands 6009, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Almeida","sequence":"additional","affiliation":[{"name":"Medical School, University of Western Australia , Nedlands 6009, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Etherton-Beer","sequence":"additional","affiliation":[{"name":"Medical School, University of Western Australia , Nedlands 6009, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0841-2216","authenticated-orcid":false,"given":"Erin","family":"Kelty","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, University of Western Australia , Nedlands 6009, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"2024090623345472300_ref1","volume-title":"National, State and Territory Population","author":"Australian Bureau of Statistics (ABS)","year":"2023"},{"key":"2024090623345472300_ref2","author":"Australian Medicines Handbook","year":"2024"},{"key":"2024090623345472300_ref3","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.drugalcdep.2014.11.029","article-title":"Delay to first treatment contact for alcohol use disorder","volume":"147","author":"Chapman","year":"2015","journal-title":"Drug Alcohol 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opioid dependence","volume":"99","author":"Weiss","year":"2004","journal-title":"Addiction"},{"key":"2024090623345472300_ref33","volume-title":"Examining the Social and Economic Costs of Alcohol Use in Australia: 2017\/18","author":"Whetton","year":"2021"},{"key":"2024090623345472300_ref34","volume-title":"Global Status Report on Alcohol and Health","author":"World Health Organisation (WHO)","year":"2018"},{"key":"2024090623345472300_ref35","volume-title":"Global Status Report on Alcohol and Health and Treatment of Substance Use Disorders","author":"World Health Organisation (WHO)","year":"2024"}],"container-title":["Alcohol and 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Journal"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.16268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T10:12:06Z","timestamp":1702116726000},"score":7.5546494,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.16268"}},"issued":{"date-parts":[[2023,11]]},"references-count":8,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/imj.16268"],"URL":"https:\/\/doi.org\/10.1111\/imj.16268","archive":["Portico"],"ISSN":["1444-0903","1445-5994"],"issn-type":[{"type":"print","value":"1444-0903"},{"type":"electronic","value":"1445-5994"}],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"2023-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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Council","doi-asserted-by":"publisher","award":["2009322"],"award-info":[{"award-number":["2009322"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020265","name":"Stan Perron Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2025,11,17]]},"published-print":{"date-parts":[[2025,12]]},"abstract":"\n Objective<\/jats:title>\n To translate and validate the HLS-Child-Q15, a relatively short questionnaire for assessing health literacy in children originally validated in German, into English to make it accessible to a large population of English-speaking children.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n We translated the HLS-Child-Q15 into English following established methods, including forward and backward translation, using multiple translators. We incorporated clinician and consumer input into the translation process. We conducted a qualitative pre-test to assess comprehension and a validation to assess psychometric properties and test-retest reliability.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Perth Children\u2019s Hospital, Perth, Western Australia<\/jats:p>\n <\/jats:sec>\n \n Patients<\/jats:title>\n We recruited English-speaking children aged 8 to 15 years.<\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n Qualitative analysis of pre-test interviews, Cronbach\u2019s \u03b1 coefficient for internal consistency and intraclass correlation coefficient for test-retest reliability.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The translation process yielded an acceptable translation. A qualitative pre-test conducted with 10 children demonstrated good comprehension of questionnaire items and resulted in small changes to increase item clarity. Validation with 207 participants demonstrated that questionnaire output score increased with age, school year, self-efficacy score, parental educational level and home literacy environment score. Internal consistency was assessed, with a Cronbach\u2019s \u03b1 coefficient of 0.854 (95% CI 0.812 to 0.887). Test-retest reliability was moderate, with an intraclass correlation coefficient of 0.612 (95% CI 0.402 to 0.761).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The translated HLS-Child-Q15 was well understood by children. Validation of the translated questionnaire demonstrated adequate psychometric properties, consistent with the original German questionnaire. The translated HLS-Child-Q15 is suitable for use with English-speaking children.<\/jats:p>\n <\/jats:sec>\n \n Data availability statement<\/jats:title>\n Data are available on reasonable request and in compliance with institutional ethics and governance requirements.<\/jats:p>\n <\/jats:sec>\n \n Trial registration number<\/jats:title>\n ACTRN12622001499774<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2025-110215","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:20:23Z","timestamp":1765974023000},"page":"e110215","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Health literacy scale for English-speaking children: translation and validation of the HLS-Child-Q15-EN"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7649-3951","authenticated-orcid":false,"given":"Thomas Frazer Eagle","family":"Drake-Brockman","sequence":"first","affiliation":[{"name":"Institute for Paediatric Perioperative Excellence, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Anaesthesia and Pain Medicine, Perth Children\u2019s Hospital, Child and Adolescent Health Service, Nedlands, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Perioperative Medicine Team, The Kids Research Institute Australia, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vance","family":"Locke","sequence":"additional","affiliation":[{"name":"Institute for Paediatric Perioperative Excellence, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"School of Psychology, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Hauser","sequence":"additional","affiliation":[{"name":"Institute for Paediatric Perioperative Excellence, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Anaesthesia and Pain Medicine, Perth Children\u2019s Hospital, Child and Adolescent Health Service, Nedlands, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Perioperative Medicine Team, The Kids Research Institute Australia, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Sommerfield","sequence":"additional","affiliation":[{"name":"Institute for Paediatric Perioperative Excellence, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Anaesthesia and Pain Medicine, Perth Children\u2019s Hospital, Child and Adolescent Health Service, Nedlands, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Perioperative Medicine Team, The Kids Research Institute Australia, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisy","family":"Evans","sequence":"additional","affiliation":[{"name":"Institute for Paediatric Perioperative Excellence, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Anaesthesia and Pain Medicine, Perth Children\u2019s Hospital, Child and Adolescent Health Service, Nedlands, Western Australia, Australia"},{"name":"Perioperative Medicine Team, The Kids Research Institute Australia, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8418-5572","authenticated-orcid":false,"given":"Aine","family":"Sommerfield","sequence":"additional","affiliation":[{"name":"Institute for Paediatric Perioperative Excellence, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Anaesthesia and Pain Medicine, Perth Children\u2019s Hospital, Child and Adolescent Health Service, Nedlands, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Perioperative Medicine Team, The Kids Research Institute Australia, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazim","family":"Khan","sequence":"additional","affiliation":[{"name":"Institute for Paediatric Perioperative Excellence, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"School of Physics, Maths and Computing, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8043-8541","authenticated-orcid":false,"given":"Britta Sylvia","family":"von Ungern-Sternberg","sequence":"additional","affiliation":[{"name":"Institute for Paediatric Perioperative Excellence, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Anaesthesia and Pain Medicine, Perth Children\u2019s Hospital, Child and Adolescent Health Service, Nedlands, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Perioperative Medicine Team, The Kids Research Institute Australia, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"2026021904051927000_15.12.e110215.1","unstructured":"Health literacy. Australian Commission on Safety and Quality in Health Care. 2014 Available: https:\/\/www.safetyandquality.gov.au\/our-work\/patient-and-consumer-centred-care\/health-literacy"},{"key":"2026021904051927000_15.12.e110215.2","unstructured":"Australian Commission on Safety and Quality in Health Care . Health literacy: taking action to improve safety and quality. 2014. Available: https:\/\/www.safetyandquality.gov.au\/sites\/default\/files\/migrated\/Health-Literacy-Taking-action-to-improve-safety-and-quality.pdf"},{"key":"2026021904051927000_15.12.e110215.3","unstructured":"World Health Organisation . Health literacy in the context of health, well-being and learning outcomes the case of children and adolescents in schools, 2021. Available: https:\/\/www.who.int\/europe\/publications\/i\/item\/WHO-EURO-2021-2846-42604-59268"},{"key":"2026021904051927000_15.12.e110215.4","first-page":"e144","article-title":"Adapting the European Health Literacy Survey Questionnaire for Fourth-Grade Students in Germany: Validation and Psychometric Analysis","volume":"4","author":"Bollweg","year":"2020","journal-title":"HLRP: Health Literacy Research and Practice"},{"key":"2026021904051927000_15.12.e110215.5","first-page":"e119","article-title":"Adapting the European Health Literacy Survey for Fourth-Grade Students in Germany: Questionnaire Development and Qualitative Pretest","volume":"4","author":"Bollweg","year":"2020","journal-title":"HLRP: Health Literacy Research and Practice"},{"key":"2026021904051927000_15.12.e110215.6","doi-asserted-by":"crossref","first-page":"5244","DOI":"10.3390\/ijerph18105244","article-title":"Measuring and Exploring Children\u2019s Health Literacy in The Netherlands: Translation and Adaptation of the HLS-Child-Q15","volume":"18","author":"Hahnraths","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"2026021904051927000_15.12.e110215.7","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.3928\/24748307-20230717-01","article-title":"Measuring Health Literacy Among French Pupils With the Health Literacy Survey Child Questionnaire-15 (HLS-Child-Q15)","volume":"7","author":"Genton","year":"2023","journal-title":"HLRP: Health Literacy Research and Practice"},{"key":"2026021904051927000_15.12.e110215.8","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.834825","article-title":"Preparing for Pediatrics: Experiential Learning Helps Medical Students Prepare for Their Clinical Placement","volume":"10","author":"Sullivan","year":"2022","journal-title":"Front Pediatr"},{"key":"2026021904051927000_15.12.e110215.9","doi-asserted-by":"crossref","DOI":"10.1111\/aas.70135","article-title":"Children\u2019s Anxiety in the Perioperative Environment: A Qualitative Exploration With Children, Parents and Staff at a Tertiary Paediatric Hospital","volume":"69","author":"Drake-Brockman","year":"2025","journal-title":"Acta Anaesthesiol Scand"},{"key":"2026021904051927000_15.12.e110215.10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0332570","article-title":"A qualitative exploration of the phenomenology of pain in children to inform pain assessment methods","volume":"20","author":"Drake-Brockman","year":"2025","journal-title":"PLoS One"},{"key":"2026021904051927000_15.12.e110215.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2753.2010.01434.x"},{"key":"2026021904051927000_15.12.e110215.12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-13-117"},{"key":"2026021904051927000_15.12.e110215.13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fpubh.2018.00149","article-title":"Best Practices for Developing and Validating Scales for Health, Social, and Behavioral Research: A 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Open"],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2025-110215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:05:29Z","timestamp":1771502729000},"score":7.5545983,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2025-110215"}},"issued":{"date-parts":[[2025,12]]},"references-count":17,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,17]]},"published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1136\/bmjopen-2025-110215"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2025-110215","ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"published":{"date-parts":[[2025,12]]}},{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:34:53Z","timestamp":1777664093471,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE 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In this article, we examine generational tensions in interviews with policy leaders and clinicians on workforce issues within one subset of the Australian medical profession: general practitioners who provide care to people with HIV in community settings. Integrating the accounts of policy leaders (n\u2009=\u200924) and clinicians representing the \u2018first generation\u2019 (n\u2009=\u200921) and \u2018next generation\u2019 (n\u2009=\u200923) of clinicians to do this work, shared and divergent perspectives on the role of generational change in shaping professional engagement were revealed. While those engaged in the early response to HIV believed younger clinicians to be less interested in the scientific and political dimensions of HIV care and more concerned about financial security and life balance, the next generation both countered and integrated these beliefs into new ways of conceptualising the value and appeal of this field of medicine. Critical appraisal of the assumptions that underpin generational discourse is essential in appreciating the changing views of providers over time, particularly in fields of medicine which have featured significant historical turning points.<\/jats:p>","DOI":"10.1177\/1363459315583155","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T21:01:37Z","timestamp":1430946097000},"page":"258-273","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["\u2018Who\u2019s coming up next to do this work?\u2019 Generational tensions in accounts of providing HIV care in the community"],"prefix":"10.1177","volume":"20","author":[{"given":"Christy E","family":"Newman","sequence":"first","affiliation":[{"name":"UNSW Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John BF","family":"de Wit","sequence":"additional","affiliation":[{"name":"UNSW Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Macquarie University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G","family":"Canavan","sequence":"additional","affiliation":[{"name":"Independent Advocate, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R","family":"Kidd","sequence":"additional","affiliation":[{"name":"Flinders University, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,5,6]]},"reference":[{"key":"bibr1-1363459315583155","unstructured":"Bardi J (2011) The coming dearth of doctors who specialize in HIV\/AIDS. Available at: http:\/\/www.ucsf.edu\/news\/2011\/12\/11065\/coming-dearth-doctors-who-specialize-hiv-aids (accessed 4 September 2012)."},{"key":"bibr2-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2008.06.019"},{"key":"bibr3-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1097\/01.ACM.0000225222.38078.47"},{"key":"bibr4-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"bibr5-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1007\/s11524-011-9552-y"},{"key":"bibr6-1363459315583155","first-page":"215","volume":"38","author":"Dodd J","year":"2009","journal-title":"of Allied Health"},{"key":"bibr7-1363459315583155","volume-title":"Generations, Culture and Society","author":"Edmunds J","year":"2002"},{"key":"bibr8-1363459315583155","unstructured":"Gregorio K (2013) How to work with Gen Y. The Sydney Morning Herald, 25 January. Availabe at: http:\/\/www.smh.com.au\/executive-style\/management\/how-to-work-with-gen-y-20130124-2d8e2.html (accessed on 17 April 2015)."},{"key":"bibr9-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-6-55"},{"key":"bibr10-1363459315583155","volume-title":"Word Up: The Lexicon and Language Guide to Changing Times and Emerging Generations","author":"McCrindle M","year":"2010"},{"key":"bibr11-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2923.2010.03720.x"},{"key":"bibr12-1363459315583155","volume-title":"Generations","author":"Mackay H","year":"1997"},{"key":"bibr13-1363459315583155","first-page":"276","volume-title":"Collected Works of Karl Mannheim","author":"Mannheim K","year":"1997"},{"key":"bibr14-1363459315583155","doi-asserted-by":"crossref","unstructured":"Newman CE, de Wit JBF, Crooks L, (2014) Challenges of providing HIV care in general practice. Australian Journal of Primary Health. Epub ahead of print 30 March: Available at: http:\/\/dx.doi.org\/10.1071\/PY13119","DOI":"10.1071\/PY13119"},{"key":"bibr15-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2011-050130"},{"key":"bibr16-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1080\/13691058.2011.607904"},{"key":"bibr17-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2010.02.006"},{"key":"bibr18-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-14-39"},{"key":"bibr19-1363459315583155","first-page":"734","volume":"42","author":"Newman CE","year":"2013","journal-title":"Australian Family Physician"},{"key":"bibr20-1363459315583155","volume-title":"Models of Access and Clinical Service Delivery for People with HIV in Australia: Final Report","author":"Savage J","year":"2009"},{"key":"bibr21-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1071\/PY10056"},{"key":"bibr22-1363459315583155","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.11579"},{"key":"bibr23-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2923.2009.03310.x"},{"key":"bibr24-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-4446.2005.00084.x"},{"key":"bibr25-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1111\/1468-4446.12015"},{"key":"bibr26-1363459315583155","doi-asserted-by":"publisher","DOI":"10.4159\/9780674045309"},{"key":"bibr27-1363459315583155","unstructured":"World Health Organization (2013) Global Health Observatory: HIV\/AIDS. Available at: http:\/\/www.who.int\/gho\/hiv\/en\/"},{"key":"bibr28-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1057\/sth.2012.12"},{"key":"bibr29-1363459315583155","volume-title":"Out of the Sixties: Storytelling and the Vietnam Generation","author":"Wyatt D","year":"1993"},{"key":"bibr30-1363459315583155","doi-asserted-by":"publisher","DOI":"10.1080\/13691050110149918"}],"container-title":["Health: An Interdisciplinary Journal for the Social Study of Health, Illness and Medicine"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1363459315583155","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1363459315583155","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1363459315583155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:34:48Z","timestamp":1777448088000},"score":7.554462,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1363459315583155"}},"issued":{"date-parts":[[2015,5,6]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1177\/1363459315583155"],"URL":"https:\/\/doi.org\/10.1177\/1363459315583155","ISSN":["1363-4593","1461-7196"],"issn-type":[{"value":"1363-4593","type":"print"},{"value":"1461-7196","type":"electronic"}],"published":{"date-parts":[[2015,5,6]]}},{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T17:10:15Z","timestamp":1756660215424,"version":"3.44.0"},"reference-count":0,"publisher":"BMJ Publishing Group Ltd","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"unspecified","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1136\/bmjsem-2025-sportskongres.7","type":"proceedings-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T02:00:17Z","timestamp":1736992817000},"page":"A3.1-A3","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["7\u2005Diagnostic information has an immediate effect on pain in patients with achilles tendinopathy? A randomised controlled clinical experiment"],"prefix":"10.1136","author":[{"given":"Nigel","family":"Travers","sequence":"first","affiliation":[{"name":"The University of Notre Dame Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mervyn","family":"Travers","sequence":"additional","affiliation":[{"name":"The University of Notre Dame Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Gibson","sequence":"additional","affiliation":[{"name":"The University of Notre Dame Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Debenham","sequence":"additional","affiliation":[{"name":"The University of Notre Dame Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Hince","sequence":"additional","affiliation":[{"name":"The University of Notre Dame Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedict","family":"Wand","sequence":"additional","affiliation":[{"name":"The University of Notre Dame Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,1,15]]},"event":{"name":"#Sportskongres 2025, 23\u201325 January, Copenhagen, Denmark"},"container-title":["Achilles-foot"],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjsem-2025-sportskongres.7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T16:47:10Z","timestamp":1756658830000},"score":7.554336,"resource":{"primary":{"URL":"https:\/\/bmjopensem.bmj.com\/lookup\/doi\/10.1136\/bmjsem-2025-sportskongres.7"}},"issued":{"date-parts":[[2025,1]]},"references-count":0,"alternative-id":["10.1136\/bmjsem-2025-sportskongres.7"],"URL":"https:\/\/doi.org\/10.1136\/bmjsem-2025-sportskongres.7","published":{"date-parts":[[2025,1]]}},{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T03:31:05Z","timestamp":1786419065582,"version":"build-2736575974"},"reference-count":81,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspsychub.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brit J of Edu Psychol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Parent involvement strongly correlates with children's educational attainment. Sociocultural shifts in parenting roles and shared responsibilities have driven an increase in the need for involvement of fathers in activities to support their children's educational development. Several factors are thought to influence father involvement in children's education; however, the most salient factors remain unclear.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n To examine which variables correlate with father involvement in their children's education using a combination of demographic, parent\u2010related and employment\u2010related variance.<\/jats:p>\n <\/jats:sec>\n \n Sample<\/jats:title>\n A total of 166 fathers of at least one child aged 6\u201317\u2009years and residing across five industrialized Western countries participated in an online survey.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n Hierarchical multiple regression analysis (HMRA) was performed to examine the total and incremental variance using regression models including demographic, parenting\u2010 and employment\u2010related variables linked to educational involvement.<\/jats:p>\n <\/jats:sec>\n \n Results and Conclusions<\/jats:title>\n The variables included in the current study could explain a large and statistically significant 34% of the variability in fathers' educational involvement. Of these variables, only four were statistically significant in the final model. Specifically, fathers were more likely to be engaged in their children's education when their children were younger, and when parent self\u2010efficacy, positive work\u2010to\u2010family interface and financial anxiety were high. The study's findings indicate that a positive work environment can help fathers better support their children's education, offering a new focus for future interventions and policies. 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We present lessons learnt during the development and implementation of our operational processes and procedures at The Royal Flying Doctor Service (RFDS) Western Operations for the transfer of suspected COVID-19 patients. To date, we have conducted 105 such fixed-wing transfers. The unique geography and health care system of Western Australia mandates that long-range, fixed-wing transfers are often required to centralised tertiary care. These lessons learnt provide a framework for the essential logistical, equipment and human factor considerations for developing an effective system. The translation of predominantly hospital-centric protocols into the aviation environment requires careful forethought, effective leadership and teamwork. Conducting COVID-19 suspected aeromedical retrievals significantly impacts all aeromedical retrieval operations and aeromedical personnel that should be realised by an aeromedical organisation.<\/jats:p>","DOI":"10.21307\/asam-2020-003","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T03:00:08Z","timestamp":1611802808000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["CHALLENGES OF COVID-19 AEROMEDICAL RETRIEVAL: LESSONS LEARNT FROM CONDUCTING AEROMEDICAL TRANSFERS DURING A PANDEMIC"],"prefix":"10.2478","volume":"12","author":[{"given":"Gihan","family":"Ganesh","sequence":"first","affiliation":[{"name":"Royal Flying Doctors Service of Australia, Western Operations ; Western Australia ; Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayle","family":"Christie","sequence":"additional","affiliation":[{"name":"Royal Flying Doctors Service of Australia, Western Operations ; Western Australia ; Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"McIlroy","sequence":"additional","affiliation":[{"name":"Royal Flying Doctors Service of Australia, Western Operations ; Western Australia ; Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley","family":"Dutton","sequence":"additional","affiliation":[{"name":"Royal Flying Doctors Service of Australia, Western Operations ; Western Australia ; Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Challen","sequence":"additional","affiliation":[{"name":"Royal Flying Doctors Service of Australia, Western Operations ; Western Australia ; Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"2026042712101037585_j_asam-2020-003_ref_001","doi-asserted-by":"crossref","unstructured":"Chu DK, Akl EA, Duda S, Solo K, Yaacoub S, Schunemann. Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. Lancet. 2020; 395: 1973 \u2013 1987","DOI":"10.1016\/S0140-6736(20)31142-9"},{"key":"2026042712101037585_j_asam-2020-003_ref_002","doi-asserted-by":"crossref","unstructured":"Scales DC, Green K, Chan AK et al. Illness in intensive care staff after brief exposure to severe acute respiratory syndrome. Emerg Infect Dis. 2003; 9: 1205 \u2013 10","DOI":"10.3201\/eid0910.030525"},{"key":"2026042712101037585_j_asam-2020-003_ref_003","unstructured":"Infection prevention and control during healthcare when COVID-19 is suspected: interim guidance, Geneva: World Health Organization; 20202020. [updated 19 Mar 2020, cited 28 Jun 2020]. WHO\/2019-nCoV\/IPC\/2020.3. Available from URL: https:\/\/www.who.int\/publications\/i\/item\/infectio n-prevention-and-control-during-health-care-when-novel-coronavirus-(ncov)-infection-is-suspected-20200125"},{"key":"2026042712101037585_j_asam-2020-003_ref_004","doi-asserted-by":"crossref","unstructured":"Dexter F, Para MC, Brown JR, Loftus RW. Perioperative COVID-19 defense: An evidence-based approach for optimisation of infection control and operating room management. Anaes Analg. 2020; 131(1): 37 \u2013 42","DOI":"10.1213\/ANE.0000000000004829"},{"key":"2026042712101037585_j_asam-2020-003_ref_005","doi-asserted-by":"crossref","unstructured":"Clay-Williams R, Colligan L. Back to basics: checklists in aviation and healthcare. BMJ Qual Saf. 2015; 24(7): 428 \u2013 431","DOI":"10.1136\/bmjqs-2015-003957"},{"key":"2026042712101037585_j_asam-2020-003_ref_006","unstructured":"Department of Fire and Emergency Services. Directive 3.6 \u2013 HAZMAT\/CBRN; SOP 3.6.3 \u2013 Decontamination. Version 1.5 [updated April 2019, cited Feb 2019]. Available from URL: https:\/\/connect.dfes.wa.gov.au\/simplesaml\/mod ule.php\/dfesmultiauth\/selectsource.php?AuthSta te=_a97b5339870030658a3821f17242708b0a8808b838"},{"key":"2026042712101037585_j_asam-2020-003_ref_007","doi-asserted-by":"crossref","unstructured":"Verbeek JH, Rajamaki B, Ijaz S et al. Personal protective equipment for preventing highly infectious diseases due to exposure to contaminated body fluids in healthcare Cochrane Database of Systematic Reviews. 2019; 7: Art. No.: CD011621","DOI":"10.1002\/14651858.CD011621.pub3"},{"key":"2026042712101037585_j_asam-2020-003_ref_008","doi-asserted-by":"crossref","unstructured":"Suen, LKP, Guo YP, Tong DWK et al. Self-contamination during doffing of personal protective equipment by healthcare workers to prevent Ebola transmission. Antimicrob Resist Infect Control. 2018; 7: 157","DOI":"10.1186\/s13756-018-0433-y"},{"key":"2026042712101037585_j_asam-2020-003_ref_009","unstructured":"Guidance for donning and doffing personal protective equipment (PPE) during management of patients with Ebola virus disease in U.S. hospitals [updated 25 Jul 2019, cited 28 Jun 2019]. Available from URL: https:\/\/www.cdc.gov\/vhf\/ebola\/hcp\/ppe-training\/index.html"},{"key":"2026042712101037585_j_asam-2020-003_ref_010","doi-asserted-by":"crossref","unstructured":"Adams JG, Walls RM. 2020. Supporting the health care workforce during the COVID-19 global epidemic. JAMA. 2020; 323(15): 1439\u20131440","DOI":"10.1001\/jama.2020.3972"}],"container-title":["Journal of the Australasian Society of Aerospace Medicine"],"language":"en","link":[{"URL":"https:\/\/reference-global.com\/pdf\/10.21307\/asam-2020-003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:17:17Z","timestamp":1777317437000},"score":7.554166,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.21307\/asam-2020-003"}},"issued":{"date-parts":[[2021,1,1]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,29]]},"published-print":{"date-parts":[[2021,1,1]]}},"alternative-id":["10.21307\/asam-2020-003"],"URL":"https:\/\/doi.org\/10.21307\/asam-2020-003","ISSN":["2639-6416"],"issn-type":[{"value":"2639-6416","type":"electronic"}],"published":{"date-parts":[[2021,1,1]]}},{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T16:27:44Z","timestamp":1787329664641,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100024780","name":"Digital Health CRC","doi-asserted-by":"publisher","award":["DHCRC\u20100076"],"award-info":[{"award-number":["DHCRC\u20100076"]}],"id":[{"id":"10.13039\/501100024780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Psychosis is a debilitating condition and prompt treatment is a key prognostic factor. Early intervention services aim to provide timely care, but co\u2010occurring substance use disorders (SUDs) complicate treatment, leading to poorer outcomes. This study examined the clinical journey of individuals with SUD who were subsequently diagnosed with a psychotic disorder, focusing on the interval between diagnoses to understand this issue.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patient pathways were constructed using linked health data (2005\u20132022) from Western Australia for individuals aged \u2265\u200918\u2009years with a diagnosis of SUD followed by a primary psychotic disorder. Service events across emergency departments (EDs), inpatient and community mental health services were analysed. Descriptive statistics and subgroup analyses examined variations based on the time between diagnoses, sex, remoteness and socioeconomic status.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Analysis of 7568 patient pathways revealed a median diagnostic interval of 1.9\u2009years. Initial SUD diagnoses occurred most frequently in inpatient settings (62%), whilst psychoses diagnoses were most common in EDs (46%). Common diagnostic pathways included inpatient to ED (28%) and inpatient to inpatient (24%). Subgroup analyses showed women had a 7\u2010month longer diagnostic interval and six more mental health service events than men. Remoteness and socioeconomic disadvantage correlated with increased diagnosis in inpatient settings and decreased diagnosis in EDs.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n A significant delay between diagnoses is likely associated with poorer outcomes. Integrated service delivery, particularly between EDs and specialised mental health services, is important for early intervention. Patient demographics and geographic location influence diagnostic pathways, suggesting targeted interventions to improve access to prompt, appropriate care.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/eip.70211","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:30:04Z","timestamp":1782696604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Public Health Service Clinical Journeys of Patients With Primary Substance Use Disorders Who Are Subsequently Diagnosed With Non\u2010Affective Psychotic Disorders"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1645-0922","authenticated-orcid":false,"given":"Kevin E. K.","family":"Chai","sequence":"first","affiliation":[{"name":"School of Population Health, Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvis","family":"Rapoo","sequence":"additional","affiliation":[{"name":"Western Australia Country Health Service Geraldton Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6613-5491","authenticated-orcid":false,"given":"Crystal M. Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Population Health, Curtin University Perth Western Australia Australia"},{"name":"Deakin Health Economics, Deakin University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2924-6760","authenticated-orcid":false,"given":"Peter M.","family":"McEvoy","sequence":"additional","affiliation":[{"name":"School of Population Health, Curtin University Perth Western Australia Australia"},{"name":"Centre for Clinical Interventions, North Metropolitan Health Service Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7794-6211","authenticated-orcid":false,"given":"Kyran","family":"Graham\u2010Schmidt","sequence":"additional","affiliation":[{"name":"Western Australia Department of Health Perth Western Australia 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Psychiatry"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eip.70211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/eip.70211","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eip.70211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T15:28:09Z","timestamp":1787326089000},"score":7.554134,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eip.70211"}},"issued":{"date-parts":[[2026,6,28]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/eip.70211"],"URL":"https:\/\/doi.org\/10.1111\/eip.70211","archive":["Portico"],"ISSN":["1751-7885","1751-7893"],"issn-type":[{"value":"1751-7885","type":"print"},{"value":"1751-7893","type":"electronic"}],"published":{"date-parts":[[2026,6,28]]},"assertion":[{"value":"2025-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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Circular RNAs (circRNA), a novel and underexplored RNA type, are created by the back-splicing of pre-mRNA and have been proposed to regulate gene expression post-transcriptionally via targeting micro RNAs (miRNA). Heart related circRNA (Hrcr) has been proposed as an important regulator of LVH and has been shown to be downregulated in mice with cardiac hypertrophy induced by chronic infusion of isoproterenol.<\/jats:p>\n Our aim was to investigate the expression of Hrcr in the hypertrophic heart during development and at maturity. We used the hypertrophic heart rat (HHR), a unique normotensive polygenic model of LVH and heart failure, and its genetic control strain, the normal heart rat (NHR). We first measured the expression of Hrcr by quantitative real-time PCR in left ventricles of HHR and NHR at five ages (2 days old, 4-, 13-, 33- and 50-weeks old). Secondly, we silenced HRCR in human primary cardiomyocytes and performed small RNA sequencing to reveal its miRNA downstream targets. Lastly, we performed in silico investigations to predict miRNA-mRNA targets and explore enriched gene ontology terms in our dataset.We found that Hrcr is upregulated in the HHR at 13-, 33- and 50-weeks old (FC\u200a=\u200a2.77-3.57; P\u200a<\u200a0.05). The silencing of HRCR revealed novel downstream targets, including four miRNAs (miR-1-3p, miR-330, miR-27a-5p and miR-299-5p) and two noncoding RNAs (ribosomal RNA RNA5-8SP2 and piwi-interacting RNA piR-17153). The miRNA-mRNA interactions predicted a total of 359 mRNAs highly likely to be targeted by the differentially expressed miRNAs. Lastly, 206 gene ontology terms were enriched in our dataset, including terms related to heart development and cardiovascular disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/01.hjh.0000914456.94266.10","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T17:42:02Z","timestamp":1673545322000},"page":"e176-e177","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["PS-B02-9: HEART RELATED CIRCULAR RNA (HRCR) INFLUENCES POLYGENIC CARDIAC HYPERTROPHY BY ALTERING CARDIAC MICRORNAS"],"prefix":"10.1097","volume":"41","author":[{"given":"Priscilla Ribeiro","family":"Prestes","sequence":"first","affiliation":[{"name":"Federation University Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle Carla","family":"Maier","sequence":"additional","affiliation":[{"name":"Federation University Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Byars","sequence":"additional","affiliation":[{"name":"University of Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen B","family":"Harrap","sequence":"additional","affiliation":[{"name":"University of Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi J","family":"Charchar","sequence":"additional","affiliation":[{"name":"Federation University Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Journal of Hypertension"],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/01.hjh.0000914456.94266.10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T19:44:49Z","timestamp":1724442289000},"score":7.5540876,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/01.hjh.0000914456.94266.10"}},"issued":{"date-parts":[[2023,1]]},"references-count":0,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1097\/01.hjh.0000914456.94266.10","ISSN":["0263-6352","1473-5598"],"issn-type":[{"type":"print","value":"0263-6352"},{"type":"electronic","value":"1473-5598"}],"published":{"date-parts":[[2023,1]]}},{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:05:37Z","timestamp":1787972737420,"version":"build-2784847793"},"reference-count":51,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T00:00:00Z","timestamp":1632009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nurs Ethics"],"published-print":{"date-parts":[[2022,3]]},"abstract":"Research suggests that the incidence of moral distress experienced by health professionals is significant and increasing, yet the concept lacks clarity and remains largely misunderstood. Currently, there is limited understanding of moral distress in the context of midwifery practice. The term moral distress was first used to label the psychological distress experienced following complex ethical decision-making and moral constraint in nursing. The term is now used across multiple health professions including midwifery, nursing, pharmacy and medicine, yet is used cautiously due to confusion regarding its theoretical and contextual basis. The aim of this study is to understand the concept of moral distress in the context of midwifery practice, describing the attributes, antecedents and consequences. This concept analysis uses Rodgers\u2019 evolutionary framework and is the first stage of a sequential mixed-methods study. A literature search was conducted using multiple databases resulting in eight articles for review. Data were analysed using NVivo12\u00a9. Three core attributes were identified: moral actions and inactions, conflicting needs and negative feelings\/emotions. The antecedents of clinical situations, moral awareness, uncertainty and constraint were identified. Consequences of moral distress include adverse personal professional and organisational outcomes. A model case depicting these aspects is presented. A midwifery focused definition of moral distress is offered as \u2018a psychological suffering following clinical situations of moral uncertainty and\/or constraint, which result in an experience of personal powerlessness where the midwife perceives an inability to preserve all competing moral commitments\u2019. This concept analysis affirms the presence of moral distress in midwifery practice and provides evidence to move towards a consistent definition of moral distress.<\/jats:p>","DOI":"10.1177\/09697330211023983","type":"journal-article","created":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T23:10:38Z","timestamp":1632093038000},"page":"364-383","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Moral distress in midwifery practice: A concept analysis"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9883-9450","authenticated-orcid":false,"given":"Wendy","family":"Foster","sequence":"first","affiliation":[{"name":"University of South Australia, Australia; Flinders University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois","family":"McKellar","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6228-5636","authenticated-orcid":false,"given":"Julie","family":"Fleet","sequence":"additional","affiliation":[{"name":"University of South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Sweet","sequence":"additional","affiliation":[{"name":"Deakin University, Australia; Flinders University, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,19]]},"reference":[{"key":"bibr1-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1016\/j.midw.2012.04.006"},{"key":"bibr2-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1111\/ijn.12630"},{"key":"bibr3-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1111\/jonm.12273"},{"key":"bibr4-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1016\/j.wombi.2019.01.001"},{"key":"bibr5-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1001\/journalofethics.2017.19.6.nlit1-1706"},{"key":"bibr6-09697330211023983","volume-title":"Nursing practice: the ethical issues","author":"Jameton A","year":"1984"},{"key":"bibr7-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1177\/0969733019874492"},{"key":"bibr8-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6909.1989.tb00503.x"},{"key":"bibr9-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-6198.1987.tb00794.x"},{"key":"bibr10-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1007\/s10730-018-9349-4"},{"key":"bibr11-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-64626-8_4"},{"key":"bibr12-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1086\/JCE200920406"},{"key":"bibr13-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1177\/1359105318794842"},{"key":"bibr14-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1177\/0969733018761174"},{"key":"bibr15-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2018.2011.00647.x"},{"key":"bibr16-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1177\/1359105315595120"},{"key":"bibr17-09697330211023983","doi-asserted-by":"publisher","DOI":"10.4037\/ajcc2017786"},{"key":"bibr18-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1177\/0969733012462049"},{"key":"bibr19-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1016\/j.jen.2012.12.009"},{"key":"bibr20-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1177\/0969733014557139"},{"key":"bibr21-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1111\/jnu.12115"},{"key":"bibr22-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1001\/journalofethics.2017.19.6.mhst1-1706"},{"issue":"4","key":"bibr23-09697330211023983","first-page":"217","volume":"25","author":"Pendry PS","year":"2007","journal-title":"Nurs Econ"},{"key":"bibr24-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.1989.tb03420.x"},{"key":"bibr25-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1891\/9780826126825"},{"key":"bibr26-09697330211023983","first-page":"7","volume-title":"Concept development in nursing","author":"Rodgers BL","year":"2000","edition":"2"},{"key":"bibr27-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-6712.2010.00845.x"},{"key":"bibr28-09697330211023983","volume-title":"Nursing diagnosis: application to clinical practice","author":"Carpenito-Moyet LJ","year":"2008"},{"key":"bibr29-09697330211023983","unstructured":"Moral. Merriam-Webster Online Dictionary, 2020, https:\/\/www.merriam-webster.com\/dictionary\/moral (accessed 14 April 2020)."},{"key":"bibr30-09697330211023983","volume-title":"This is ethics: an introduction","author":"Suikkanen J","year":"2014"},{"key":"bibr31-09697330211023983","unstructured":"Distress. Merriam-Webster Online Dictionary, 2020, https:\/\/www.merriam-webster.com\/dictionary\/distress (accessed 20 April 2020)."},{"key":"bibr32-09697330211023983","volume-title":"Recognition and alleviation of distress in laboratory animals","author":"National Research Council (US)","year":"2008"},{"key":"bibr33-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1177\/0969733017724354"},{"key":"bibr34-09697330211023983","unstructured":"Wurzbach ME.\n Experiencing moral uncertainty in practice\n , 2015, http:\/\/hdl.handle.net\/10755\/581749"},{"key":"bibr35-09697330211023983","first-page":"8","volume":"1999","author":"Papazoglou K","year":"2017","journal-title":"Front Psychol"},{"key":"bibr36-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22405"},{"key":"bibr37-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1191\/0969733003ne608oa"},{"key":"bibr38-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1300\/J010v46n03_02"},{"issue":"4","key":"bibr39-09697330211023983","first-page":"5","volume":"82","author":"West J","year":"2007","journal-title":"Kans Nurse"},{"key":"bibr40-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1037\/a0036090"},{"key":"bibr41-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1891\/rtnp.19.1.95.66335"},{"key":"bibr42-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"bibr43-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1177\/0969733019874503"},{"key":"bibr44-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1016\/j.wombi.2012.11.003"},{"key":"bibr45-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1177\/0969733018796680"},{"key":"bibr46-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1755"},{"key":"bibr47-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1177\/0193945905284727"},{"key":"bibr48-09697330211023983","doi-asserted-by":"publisher","DOI":"10.3912\/OJIN.Vol15No03Man01"},{"key":"bibr49-09697330211023983","doi-asserted-by":"publisher","DOI":"10.1177\/0969733019884621"},{"key":"bibr50-09697330211023983","unstructured":"International Confederation of Midwives. International code of ethics for midwives, 2014, https:\/\/www.internationalmidwives.org\/assets\/files\/general-files\/2019\/10\/eng-international-code-of-ethics-for-midwives.pdf"},{"issue":"3","key":"bibr51-09697330211023983","first-page":"264","volume":"49","author":"Pelvin B","year":"2004","journal-title":"J Midwifery Womens Health"}],"container-title":["Nursing Ethics"],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09697330211023983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09697330211023983","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09697330211023983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:43:38Z","timestamp":1777679018000},"score":7.5539656,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09697330211023983"}},"issued":{"date-parts":[[2021,9,19]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1177\/09697330211023983"],"URL":"https:\/\/doi.org\/10.1177\/09697330211023983","ISSN":["0969-7330","1477-0989"],"issn-type":[{"value":"0969-7330","type":"print"},{"value":"1477-0989","type":"electronic"}],"published":{"date-parts":[[2021,9,19]]}},{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:40:14Z","timestamp":1777336814559,"version":"3.51.4"},"reference-count":0,"publisher":"Walter 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Gilchrist","sequence":"additional","affiliation":[{"name":"Australian Catholic University, Australia , Brisbane , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Australian Catholic University, Australia , Brisbane , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kylie","family":"Pappalardo","sequence":"additional","affiliation":[{"name":"Australian Catholic University, Australia , Brisbane , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunle","family":"Ola","sequence":"additional","affiliation":[{"name":"Australian Catholic University, Australia , Brisbane , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezieddin","family":"Elmahjub","sequence":"additional","affiliation":[{"name":"Australian Catholic University, Australia , Brisbane , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedict","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Australian Catholic University, Australia , Brisbane , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,6,21]]},"container-title":["Cultural Science Journal"],"language":"en","link":[{"URL":"https:\/\/reference-global.com\/pdf\/10.5334\/csci.67","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:46:25Z","timestamp":1777333585000},"score":7.5539174,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.5334\/csci.67"}},"issued":{"date-parts":[[2014,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,6,21]]},"published-print":{"date-parts":[[2014,6,21]]}},"alternative-id":["10.5334\/csci.67"],"URL":"https:\/\/doi.org\/10.5334\/csci.67","ISSN":["1836-0416"],"issn-type":[{"value":"1836-0416","type":"electronic"}],"published":{"date-parts":[[2014,1,1]]}},{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T01:02:04Z","timestamp":1780707724941,"version":"3.54.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2026,6,5]]},"abstract":"Introduction and Objective: Young women with type 1 diabetes (T1D) have a high prevalence of eating disorder (ED), resulting in suboptimal glycemia, early diabetes complications and mortality. Few ED prevention interventions have been evaluated in T1D and none have demonstrated significant metabolic benefit. To evaluate the effectiveness of the novel virtually-delivered peer-facilitated Australian Diabetes Body Project (ADBP), a cognitive-dissonance-based ED prevention program, in a clinic setting.<\/jats:p>\n Methods: Women with T1D aged 15-30 years were randomized to ADBP or active control of educational videos. ADBP comprised of 6-weekly, 1-hour, virtual, group sessions co-facilitated by a clinician and a T1D peer. Primary outcome was body dissatisfaction (BDS), secondary outcomes were thin-ideal internalization (IBSS-R), ED symptoms (EDEQ), diabetes-specific disordered eating behaviors (DEPS-R), HbA1c and CGM metrics at baseline (T1), post-intervention (T2), 3-month follow-up (T3). Glycemic outcomes were extracted from medical records. Analyses used REML mixed-effects models (ITT).<\/jats:p>\n Results: Eighty-five participants were randomized (Control n=43; ADBP n=42). Whilst no significant between-group differences were observed, both groups showed significant within-group improvements in BDS, IBSS-R and EDEQ from T1 to T2 and T3 (all p&lt;0.001). DEPS-R reductions were larger in ADBP (-7.40 at T2\/T3, p&lt;0.001) than Control (-3.47 to -5.02, p=0.029-0.002). A significant between-group difference in HbA1c at T3 favored ADBP (adjusted mean difference -1.05%, 95% CI -1.62 to -0.48, p&lt;0.001). Time-in-range and time-above-range improved more in ADBP, though nonsignificantly.<\/jats:p>\n Conclusion: A clinic-delivered ED prevention program for young women with T1D improved ED risks\/symptoms and produced a clinically meaningful and significant HbA1c reduction, suggesting ADBP also improves metabolic outcomes. These ground-breaking findings have great implications for all Diabetes Services.<\/jats:p>\n \n Disclosure<\/jats:title>\n N. D'Silva: None. N.S. Sandoval: None. S.N. Gannon: None. E. Stice: None. L. Wisting: None. S.E. Bartlett: None. J.V. Jones: None. L.K. Phillips: None. C. Hendrieckx: None.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n Mater Foundation - Betty McGrath Grant (3300)<\/jats:p>\n <\/jats:sec>","DOI":"10.2337\/db26-2805-lb","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:28:03Z","timestamp":1780705683000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["2805-LB: Clinic-Based Eating Disorder Prevention Program in Young Women with Type 1 Diabetes: Effects of the Australian Diabetes Body Project RCT"],"prefix":"10.2337","volume":"75","author":[{"given":"NEISHA","family":"D'SILVA","sequence":"first","affiliation":[{"name":"New Orleans, LA, Brisbane, Australia, Bend, OR, Oslo, Norway, Herston, Australia, South Brisbane, Australia, Geelong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NIKKA S.","family":"SANDOVAL","sequence":"additional","affiliation":[{"name":"New Orleans, LA, Brisbane, Australia, Bend, OR, Oslo, Norway, Herston, Australia, South Brisbane, Australia, Geelong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEAN N.","family":"GANNON","sequence":"additional","affiliation":[{"name":"New Orleans, LA, Brisbane, Australia, Bend, OR, Oslo, Norway, Herston, Australia, South Brisbane, Australia, Geelong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ERIC","family":"STICE","sequence":"additional","affiliation":[{"name":"New Orleans, LA, Brisbane, Australia, Bend, OR, Oslo, Norway, Herston, Australia, South Brisbane, Australia, Geelong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LINE","family":"WISTING","sequence":"additional","affiliation":[{"name":"New Orleans, LA, Brisbane, Australia, Bend, OR, Oslo, Norway, Herston, Australia, South Brisbane, Australia, Geelong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SELENA E.","family":"BARTLETT","sequence":"additional","affiliation":[{"name":"New Orleans, LA, Brisbane, Australia, Bend, OR, Oslo, Norway, Herston, Australia, South Brisbane, Australia, Geelong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JONES V.","family":"JONES","sequence":"additional","affiliation":[{"name":"New Orleans, LA, Brisbane, Australia, Bend, OR, Oslo, Norway, Herston, Australia, South Brisbane, Australia, Geelong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LIZA K.","family":"PHILLIPS","sequence":"additional","affiliation":[{"name":"New Orleans, LA, Brisbane, Australia, Bend, OR, Oslo, Norway, Herston, Australia, South Brisbane, Australia, Geelong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTEL","family":"HENDRIECKX","sequence":"additional","affiliation":[{"name":"New Orleans, LA, Brisbane, Australia, Bend, OR, Oslo, Norway, Herston, Australia, South Brisbane, Australia, Geelong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/2805-LB\/167979\/2805-LB-Clinic-Based-Eating-Disorder-Prevention","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/2805-LB\/167979\/2805-LB-Clinic-Based-Eating-Disorder-Prevention","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:28:03Z","timestamp":1780705683000},"score":7.5537667,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/75\/Supplement_1\/2805-LB\/167979\/2805-LB-Clinic-Based-Eating-Disorder-Prevention"}},"issued":{"date-parts":[[2026,6,5]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2026,6,5]]}},"URL":"https:\/\/doi.org\/10.2337\/db26-2805-lb","ISSN":["0012-1797"],"issn-type":[{"value":"0012-1797","type":"print"}],"published":{"date-parts":[[2026,6,5]]},"article-number":"2805-LB"},{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:50:43Z","timestamp":1781765443549,"version":"3.54.5"},"reference-count":15,"publisher":"BMJ","issue":"9","funder":[{"DOI":"10.13039\/501100006065","name":"Department of Health, Government of Western Australia","doi-asserted-by":"publisher","award":["Research Registrar Fellowship"],"award-info":[{"award-number":["Research Registrar Fellowship"]}],"id":[{"id":"10.13039\/501100006065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006065","name":"Department of Health, Government of Western Australia","doi-asserted-by":"publisher","award":["Research Translation Project Grant"],"award-info":[{"award-number":["Research Translation Project Grant"]}],"id":[{"id":"10.13039\/501100006065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2020,11,30]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"\n Objective<\/jats:title>\n We tested the hypothesis that patients with a potential acute coronary syndrome (ACS) and very low levels of high-sensitivity cardiac troponin I can be efficiently and safely discharged from the emergency department after a single troponin measurement.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This prospective cohort study recruited 2255 consecutive patients aged \u226518\u2009years presenting to the Emergency Department, Royal Perth Hospital, Western Australia, with chest pain without high-risk features but requiring the exclusion of ACS. Patients were managed using a guideline-recommended pathway or our novel Single Troponin Accelerated Triage (STAT) pathway. The primary outcome was the percentage of patients discharged in <3\u2009hours. Secondary outcomes included the duration of observation and death or acute myocardial infarction in the next 30 days.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The study enrolled 1131 patients to the standard cohort and 1124 to the STAT cohort. Thirty-eight per cent of the standard cohort were discharged directly from emergency department compared with 63% of the STAT cohort (p<0.001). The median duration of observation was 4.3 (IQR 3.3\u20137.1)\u2009hours in the standard cohort and 3.6 (2.6\u20135.4)\u2009hours in the STAT cohort (p<0.001), with 21% and 38% discharged in <3\u2009hours, respectively (p<0.001). No patients discharged directly from the emergency department died or suffered an acute myocardial infarction within 30 days in either cohort.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Among low-risk patients with a potential ACS, a pathway which incorporates early discharge based on a single very low level of high-sensitivity cardiac troponin increases the proportion of patients discharged directly from the emergency department, reduces length of stay and is safe.<\/jats:p>\n <\/jats:sec>\n \n Trial registration number<\/jats:title>\n ACTRN12618000797279.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/heartjnl-2020-317997","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T21:23:43Z","timestamp":1610486623000},"page":"721-727","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Single high-sensitivity troponin levels to assess patients with potential acute coronary syndromes"],"prefix":"10.1136","volume":"107","author":[{"given":"Cara","family":"Barnes","sequence":"first","affiliation":[{"name":"Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-6905","authenticated-orcid":false,"given":"Daniel M","family":"Fatovich","sequence":"additional","affiliation":[{"name":"Emergency Medicine, Royal Perth Hospital, Perth, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Centre for Clinical Research in Emergency Medicine, Harry Perkins Institute of Medical Research, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P J","family":"Macdonald","sequence":"additional","affiliation":[{"name":"Emergency Medicine, Royal Perth Hospital, Perth, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"},{"name":"Centre for Clinical Research in Emergency Medicine, Harry Perkins Institute of Medical Research, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F","family":"Alcock","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon R","family":"Spiro","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom G","family":"Briffa","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2417-4673","authenticated-orcid":false,"given":"Graham S","family":"Hillis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia"},{"name":"Medical School, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"2025101713385121000_107.9.721.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.065"},{"key":"2025101713385121000_107.9.721.2","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1001\/jamainternmed.2016.2498","article-title":"A national study of the prevalence of life-threatening diagnoses in patients with chest pain","volume":"176","author":"Hsia","year":"2016","journal-title":"JAMA Intern Med"},{"key":"2025101713385121000_107.9.721.3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv320"},{"key":"2025101713385121000_107.9.721.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.042891"},{"key":"2025101713385121000_107.9.721.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00391-8"},{"key":"2025101713385121000_107.9.721.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2015.07.006"},{"key":"2025101713385121000_107.9.721.7","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.hlc.2016.06.789","article-title":"National Heart Foundation of Australia & Cardiac Society of Australia and New Zealand: Australian Clinical Guidelines for the Management of Acute Coronary Syndromes 2016","volume":"25","author":"Chew","year":"2016","journal-title":"Heart Lung Circ"},{"key":"2025101713385121000_107.9.721.8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.7.835"},{"key":"2025101713385121000_107.9.721.9","doi-asserted-by":"publisher","DOI":"10.1007\/BF03086144"},{"key":"2025101713385121000_107.9.721.10","doi-asserted-by":"publisher","DOI":"10.1097\/HPC.0b013e31828b327e"},{"key":"2025101713385121000_107.9.721.11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.042866"},{"key":"2025101713385121000_107.9.721.12","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2562"},{"key":"2025101713385121000_107.9.721.13","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-316692"},{"key":"2025101713385121000_107.9.721.14","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-317012"},{"key":"2025101713385121000_107.9.721.15","unstructured":"A HiSTORIC moment for cardiac troponin. Available: https:\/\/www.escardio.org\/Congresses-&-Events\/ESC-Congress\/Congress-resources\/Congress-news\/a-historic-moment-for-cardiac-troponin"}],"container-title":["Heart"],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heartjnl-2020-317997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:38:57Z","timestamp":1760733537000},"score":7.5536747,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heartjnl-2020-317997"}},"issued":{"date-parts":[[2021,1,12]]},"references-count":15,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,4,12]]},"published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1136\/heartjnl-2020-317997"],"URL":"https:\/\/doi.org\/10.1136\/heartjnl-2020-317997","ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"published":{"date-parts":[[2021,1,12]]}},{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:58:32Z","timestamp":1773305912636,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T00:00:00Z","timestamp":1526947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008018","name":"Victorian Cancer Agency","doi-asserted-by":"publisher","award":["EOI09_E36"],"award-info":[{"award-number":["EOI09_E36"]}],"id":[{"id":"10.13039\/100008018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001168","name":"Cancer Council Queensland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001168","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Background<\/jats:title>New\u2010onset chronic kidney disease (CKD) following surgical management of kidney tumors is common. This study evaluated risk factors for new\u2010onset CKD after nephrectomy for T1a renal cell carcinoma (RCC) in an Australian population\u2010based cohort.<\/jats:p><\/jats:sec>Methods<\/jats:title>There were 551 RCC patients from the Australian states of Queensland and Victoria included in this study. The primary outcome was new\u2010onset CKD (eGFR <60\u2009mL\/min per 1.73\u2009m2<\/jats:sup>) and the secondary outcome was new\u2010onset moderate\u2010severe CKD (<45\u2009mL\/min per 1.73\u2009m2<\/jats:sup>). Multivariable logistic regression was used to evaluate associations between patient, tumor and health\u2010service characteristics and these outcomes.<\/jats:p><\/jats:sec>Results<\/jats:title>Forty percent (219\/551) of patients developed new\u2010onset CKD, and 12% (68\/551) experienced new\u2010onset moderate\u2010severe CKD. Risk factors for new\u2010onset CKD were age, lower preoperative eGFR, tumor size >20\u2009mm, radical nephrectomy, lower hospital caseloads (<20 cases\/year), and rural place of residence. The associations between rural place of residence and low center volume were a consequence of higher radical nephrectomy rates.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Risk factors for CKD after nephrectomy generally relate to worse baseline health, or likelihood of undergoing radical nephrectomy. Surgeons in rural centres and hospitals with low caseloads may benefit from formalized integration with specialist centers for continued professional development and case\u2010conferencing, to assist in management decisions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.25037","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T02:06:23Z","timestamp":1527041183000},"page":"1597-1610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Predictors of new\u2010onset chronic kidney disease in patients managed surgically for T1a renal cell carcinoma: An Australian population\u2010based analysis"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2808-9970","authenticated-orcid":false,"given":"Thomas","family":"Ahn","sequence":"first","affiliation":[{"name":"Princess Alexandra Hospital Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9755-9913","authenticated-orcid":false,"given":"Robert J.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital Brisbane Australia"},{"name":"QIMR Berghofer Medical Research Institute Brisbane Australia"},{"name":"University of Queensland Brisbane Australia"},{"name":"Translational Research Institute Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria M.","family":"White","sequence":"additional","affiliation":[{"name":"Cancer Council Victoria Melbourne Australia"},{"name":"Deakin University Geelong Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien M.","family":"Bolton","sequence":"additional","affiliation":[{"name":"Austin Health Melbourne Australia"},{"name":"University of Melbourne Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Coory","sequence":"additional","affiliation":[{"name":"University of Melbourne Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian D.","family":"Davis","sequence":"additional","affiliation":[{"name":"Monash University Melbourne Australia"},{"name":"Eastern Health Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross S.","family":"Francis","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital Brisbane Australia"},{"name":"University of Queensland Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham G.","family":"Giles","sequence":"additional","affiliation":[{"name":"Cancer Council Victoria Melbourne Australia"},{"name":"University of Melbourne Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenda C.","family":"Gobe","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital Brisbane Australia"},{"name":"University of Queensland Brisbane Australia"},{"name":"Translational Research Institute Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmel M.","family":"Hawley","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital Brisbane Australia"},{"name":"University of Queensland Brisbane Australia"},{"name":"Translational Research Institute Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital Brisbane Australia"},{"name":"University of Queensland Brisbane Australia"},{"name":"Translational Research Institute Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J. 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The purpose of this article was to examine the cross-sectional cross-elasticity relationships for use of time domains in a sample of Australian adolescents. This study analyzed 24-hour recall time use data collected using the Multimedia Activity Recall for Children and Adults ( N = 2,200). Using simple linear regression, the authors calculated the difference in time devoted to a reference activity (i.e., screen time, sleep, or social) given 1 hour extra in the time devoted to a criterion activity (i.e., physical activity). The most elastic activities were screen time and school-related time. Every additional hour committed to physical activity was associated with 32 minutes less screen time. This relationship was more pronounced in obese adolescents (\u221256 minutes screen time) compared with normal (\u221231 minutes) and overweight (\u221227 minutes) adolescents. Promising behavior patterns exist, with screen time appearing as a highly elastic behavior.<\/jats:p>","DOI":"10.1177\/1090198111429822","type":"journal-article","created":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T20:23:36Z","timestamp":1333139016000},"page":"732-736","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["The Elasticity of Time"],"prefix":"10.1177","volume":"39","author":[{"given":"Tim","family":"Olds","sequence":"first","affiliation":[{"name":"University of South Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia E.","family":"Ferrar","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sjaan R.","family":"Gomersall","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Maher","sequence":"additional","affiliation":[{"name":"University of South Australia, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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Oral Pathology Medicine"],"published-print":{"date-parts":[[2019,8]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>Oral potentially malignant disorders (OPMD) include a variety of mucosal lesions such as oral lichen planus (OLP), oral lichenoid lesions (OLL) and oral lichenoid dysplasia (OLD). Their rate of malignant transformation ranges from 0% to 34% and is dependent on OPMD type, lesion site and a range of risk factors. This study seeks to determine the proportion of oral lichenoid conditions that transform into oral squamous cell carcinoma (OSCC) in an Australian population.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study is a retrospective audit of patients from a private oral medicine clinic, diagnosed with OLP, OLL or OLD using clinical and histopathological data between 2006 and 2014. Patients were cross\u2010matched with Cancer Registry data for OSCC, and the rate and time to malignant transformation determined.<\/jats:p><\/jats:sec>Results<\/jats:title>OLP and OLL patients displayed a low risk of malignant transformation; 0.49% (1\/206) for OLP and 0% (0\/31) for OLL. In contrast, OLD patients, all of whom presented clinically as OLP, were at much higher risk with 6.81% (3\/44) developing OSCC over an average time of 4.6\u00a0years (\u00b12.4 SD). Rates of smoking and alcohol consumption were no higher in OLD patients compared to others.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Compared with other oral lichenoid conditions, OLD lesions are at a particularly high risk of malignant transformation and should be managed based on the presence of dysplasia and not the lichenoid inflammatory infiltrate. OLP demonstrates a relatively\u00a0low rate of malignant transformation. Diagnostic histopathology is important for discriminating OLP from OLD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12904","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T07:38:25Z","timestamp":1559893105000},"page":"538-545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Oral lichenoid dysplasia and not oral lichen planus undergoes malignant transformation at high rates"],"prefix":"10.1111","volume":"48","author":[{"given":"Kate","family":"Shearston","sequence":"first","affiliation":[{"name":"UWA Dental School University of Western Australia Nedlands Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behrooz","family":"Fateh","sequence":"additional","affiliation":[{"name":"UWA Dental School University of Western Australia Nedlands Western Australia 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progression model for head and neck cancer: implications for field cancerization","volume":"56","author":"Califano J","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780026"},{"issue":"2","key":"e_1_2_6_47_1","first-page":"323","article-title":"Molecular analysis of oral lichen planus. A premalignant lesion?","volume":"151","author":"Zhang L","year":"1997","journal-title":"Am J Pathol"}],"container-title":["Journal of Oral Pathology & Medicine"],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12904","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.12904","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T06:24:48Z","timestamp":1694327088000},"score":7.5531993,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12904"}},"issued":{"date-parts":[[2019,6,22]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/jop.12904"],"URL":"https:\/\/doi.org\/10.1111\/jop.12904","archive":["Portico"],"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"published":{"date-parts":[[2019,6,22]]},"assertion":[{"value":"2019-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]},{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T18:26:10Z","timestamp":1783189570907,"version":"3.54.6"},"reference-count":33,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:00:00Z","timestamp":1577404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000960","name":"Healthway","doi-asserted-by":"publisher","award":["32018"],"award-info":[{"award-number":["32018"]}],"id":[{"id":"10.13039\/501100000960","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"Background: Physical activity professional development programs for Early Childhood Education and Care (ECEC) educators are a viable strategy for improving preschool children\u2019s physical activity behavior. This pilot intervention evaluated the effectiveness of \u2018nature play\u2019 and \u2018fundamental movement skills\u2019 (FMS) professional development programs on ECEC educators\u2019 practices on physical activity. Methods: 148 ECEC educators from 20 ECEC centers took part in either the Nature play or FMS professional development programs in Perth, Western Australia. Educators self-reported their physical activity related practices at baseline and three months post-professional development training, using established items. Wilcoxon\u2019s test and adjusted models using Mann\u2013Whitney U tests were run at the individual educator level to examine the change between baseline and post-professional development educator physical activity behavior. Results: Educators\u2019 self-efficacy to engage children to be active significantly increased in both the Nature play and FMS professional development programs (p < 0.05). In the Nature play professional development program, ECEC educators\u2019 perceived time set aside for children to participate in nature-based play increased by 9.2%, and their perceived behavioral control for supporting general and nature-based play activities for preschool children increased by 5% and 10.3%, respectively (p < 0.05). However, these results were no longer significant after adjusting for educator socio-demographics. Conclusion: Both the Nature play and FMS professional development programs were effective in improving educators\u2019 self-efficacy to engage children to be active in Nature play or FMS activities. Larger pragmatic trials are required to confirm the impact of these professional development programs on educator perceived physical activity behavior.<\/jats:p>","DOI":"10.3390\/ijerph17010223","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T05:49:41Z","timestamp":1577684981000},"page":"223","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Nature Play and Fundamental Movement Skills Training Programs Improve Childcare Educator Supportive Physical Activity Behavior"],"prefix":"10.3390","volume":"17","author":[{"given":"Pulan","family":"Bai","sequence":"first","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Crawley, Western Australia 6009, Australia"},{"name":"Telethon Kids Institute, University of Western Australia, Nedlands, Western Australia 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-3330","authenticated-orcid":false,"given":"Ashleigh","family":"Thornton","sequence":"additional","affiliation":[{"name":"School of Human Sciences, The University of Western Australia, Crawley, Western Australia 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne","family":"Lester","sequence":"additional","affiliation":[{"name":"School of Human Sciences, The University of Western Australia, Crawley, Western Australia 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Schipperijn","sequence":"additional","affiliation":[{"name":"Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, 5230 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Trapp","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Crawley, Western Australia 6009, Australia"},{"name":"Telethon Kids Institute, University of Western Australia, Nedlands, Western Australia 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6693-0671","authenticated-orcid":false,"given":"Bryan","family":"Boruff","sequence":"additional","affiliation":[{"name":"School of Agriculture and Environment, The University of Western Australia, Crawley, Western Australia 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Ng","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, University of Western Australia, Nedlands, Western Australia 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3046-3658","authenticated-orcid":false,"given":"Elizabeth","family":"Wenden","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Crawley, Western Australia 6009, Australia"},{"name":"Telethon Kids Institute, University of Western Australia, Nedlands, Western Australia 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Christian","sequence":"additional","affiliation":[{"name":"School of Population and Global Health, The University of Western Australia, Crawley, Western Australia 6009, Australia"},{"name":"Telethon Kids Institute, University of Western Australia, Nedlands, Western Australia 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1139\/h2012-070","article-title":"Systematic review of physical activity and health in the early years (aged 0\u20134 years)","volume":"37","author":"Timmons","year":"2012","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Okely, A.D., Ghersi, D., Hesketh, K.D., Santos, R., Loughran, S.P., Cliff, D.P., Shilton, T., Grant, D., Jones, R.A., and Stanley, R.M. (2017). A collaborative approach to adopting\/adapting guidelines-The Australian 24-Hour Movement Guidelines for the early years (Birth to 5 years): An integration of physical activity, sedentary behavior, and sleep. BMC Public Health, 17.","DOI":"10.1186\/s12889-017-4867-6"},{"key":"ref_3","unstructured":"Christian, H., Rosenberg, M., Trost, S., Schipperijn, J., Maitland, C., Trapp, G., Lester, L., Boruff, B., Thornton, A., and Zubrick, S. (2018). A snapshot of the PLAYCE project: Findings from the Western Australian PLAY spaces and environments for children\u2019s physical activity study. 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Acute inflammation, which is a characteristic of gout, may have a mechanistic role in major adverse cardiovascular events (MACEs). We aimed to examine the relationship between admissions to a hospital with acute gout and MACEs in a large population\u2010based data set.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We extracted data from the Hospital Morbidity Data Collection and Death Registrations of the Western Australian Rheumatic Disease Epidemiology Registry. We identified patients admitted to hospital with incident acute gout and who had admissions or a death record because of MACEs. We compared the risk of MACEs during the postdischarge period (1\u201030\u2009days after acute gout admission) and control period (365\u2009days prior to admission and 365\u2009days after the postdischarge period) using a self\u2010controlled case\u2010series (SCCS) design, which is a within\u2010person design that controls for time\u2010invariant patient\u2010specific confounding. We performed conditional fixed\u2010effects Poisson regression to obtain rate ratios (RRs).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n We identified 941 patients (average age: 76.4\u2009years; SD: 12.6; 66.7% male) with an incident acute gout admission and documented MACEs during the control and\/or postdischarge periods. Of the 941 patients, 898 (95%) experienced MACEs during the combined control period (730\u2010day period) and 112 (12%) during the postdischarge period (30\u2010day period). The rates of MACEs during the total control and postdischarge periods were 0.84 and 1.45 events per person\u2010year, respectively. Regression analysis confirmed increased rate during the postdischarge period (RR: 1.67; 95% CI: 1.38\u20102.03) compared with the control period. Sensitivity analyses indicated that our results were robust in relation to known limitations of the SCCS design.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n We report an increased risk of MACEs in the first 30\u2009days after an incident hospital admission with acute gout, suggesting a temporal association between acute inflammation and subsequent MACEs in patients with gout.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acr2.11540","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T01:39:56Z","timestamp":1683855596000},"page":"298-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Risk of Major Adverse Cardiovascular Event Following Incident Hospitalization for Acute Gout: A Western Australian\n Population\u2010Level<\/scp>\n Linked Data 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