{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:15:03Z","timestamp":1721175303107},"publisher":"Wellcome","award":"110166","DOI":"10.35802\/110166","type":"grant","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T18:55:46Z","timestamp":1608231346000},"source":"Crossref","prefix":"10.35802","member":"13928","project":[{"project-title":[{"title":"Elucidating mechanisms of extracellular vesicle-mediated cellular communication and stage conversion in malaria parasites."}],"project-description":[{"description":"During malaria infection a small proportion of parasites stop replicating and switch to a sexual cycle leading to the formation of transmission-competent mature gametocyte stages. These sexual cells are genetically identical but undergo significant morphological differentiation during development while sequestered in tissues. It has been reported that parasite-conditioned medium can increase gametocyte formation. We have recently demonstrated that small vesicles are transferred between infected RBCs and increase gametocyte formation. A parallel study has demonstrated that DNA encoding a drug resistance locus can be transferred between parasites via vesicles of similar size, rendering the recipient population drug resistant and committed to produce sexual progeny. Together these two studies demonstrate existence of a cellular communication pathway in Plasmodium parasites that allows both for lateral gene transfer and the spread of genetic traits and for regulation of parasite phenotypes such as growth versus transmission on a population level. This is a major finding with wide implications for our understanding of parasite biology and potential for translational applications. Here we propose to dissect this communication pathway and define the pathways that are required for vesicular transfer, those that are activated in recipient cells and the factors in these vesicles that transduce information.","language":"en"}],"investigator":[{"ORCID":"http:\/\/orcid.org\/0000-0003-1040-9566","authenticated-orcid":false,"given":"Matthias","family":"Marti","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00vtgdb53","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Glasgow","country":"GB"}]}],"award-amount":{"amount":2063395.0,"currency":"GBP"},"award-start":{"date-parts":[[2016,6,1]]},"award-end":{"date-parts":[[2021,11,30]]},"funding":[{"type":"grant","scheme":"Pathogen Biology and Disease Transmission","funder":{"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}],"name":"Wellcome Trust"}}]}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T11:55:27Z","timestamp":1721130927000},"score":1,"resource":{"primary":{"URL":"https:\/\/europepmc.org\/grantfinder\/grantdetails?query=pi:\"%7BProfessor%7D%7BMarti%7D%7BMatthias%7D%7BM%7D\" gid:\"110166\" ga:\"Wellcome Trust\""}},"issued":{"date-parts":[[2016,6,1]]},"URL":"https:\/\/doi.org\/10.35802\/110166","relation":{},"subject":[]}}