{"status":"ok","message-type":"work-list","message-version":"1.0.0","message":{"facets":{},"total-results":9538,"items":[{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T04:48:55Z","timestamp":1696913335242},"reference-count":0,"publisher":"Instituto de Investigaciones Economicas y Empresariales","content-domain":{"domain":[],"crossmark-restriction":false},"DOI":"10.33110\/itsiecheri","type":"journal","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:44:53Z","timestamp":1696261493000},"source":"Crossref","is-referenced-by-count":0,"title":["itsi echeri"],"prefix":"10.33110","member":"18477","deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:45:36Z","timestamp":1696877136000},"score":16.952097,"resource":{"primary":{"URL":"https:\/\/publicaciones.umich.mx\/revistas\/itsi-echeri\/ojs\/index"}},"short-title":["itsi echeri"],"issued":{"date-parts":[[null]]},"references-count":0,"URL":"https:\/\/doi.org\/10.33110\/itsiecheri","ISSN":["2992-7196","2992-7196"],"issn-type":[{"value":"2992-7196","type":"print"},{"value":"2992-7196","type":"electronic"}]},{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T04:51:43Z","timestamp":1696913503264},"reference-count":0,"publisher":"Instituto de Investigaciones Economicas y Empresariales","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["itsi echeri"],"published-print":{"date-parts":[[2023]]},"DOI":"10.33110\/itsiecheri0","type":"journal-issue","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:06:51Z","timestamp":1696874811000},"source":"Crossref","is-referenced-by-count":0,"prefix":"10.33110","volume":"1","member":"18477","published-online":{"date-parts":[[2023]]},"container-title":["itsi echeri"],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:45:37Z","timestamp":1696877137000},"score":16.37953,"resource":{"primary":{"URL":"https:\/\/publicaciones.umich.mx\/revistas\/itsi-echeri\/ojs\/issue\/view\/2"}},"issued":{"date-parts":[[2023]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.33110\/itsiecheri0","ISSN":["2992-7196","2992-7196"],"issn-type":[{"value":"2992-7196","type":"print"},{"value":"2992-7196","type":"electronic"}],"published":{"date-parts":[[2023]]}},{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T14:13:21Z","timestamp":1696342401659},"reference-count":0,"publisher":"Instituto de Investigaciones Economicas y Empresariales","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["itsi echeri"],"published-print":{"date-parts":[[2023]]},"DOI":"10.33110\/itsiecheri00","type":"journal-issue","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:44:53Z","timestamp":1696261493000},"source":"Crossref","is-referenced-by-count":0,"prefix":"10.33110","volume":"1","member":"18477","published-online":{"date-parts":[[2023]]},"container-title":["itsi echeri"],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:44:54Z","timestamp":1696261494000},"score":16.252804,"resource":{"primary":{"URL":"https:\/\/publicaciones.umich.mx\/revistas\/itsi-echeri\/ojs\/index"}},"issued":{"date-parts":[[2023]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.33110\/itsiecheri00","ISSN":["2992-7196","2992-7196"],"issn-type":[{"value":"2992-7196","type":"print"},{"value":"2992-7196","type":"electronic"}],"published":{"date-parts":[[2023]]}},{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T16:06:52Z","timestamp":1648915612864},"reference-count":0,"publisher":"Springer Science and Business Media LLC","issue":"451supp","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci Am"],"published-print":{"date-parts":[[1884,8,23]]},"DOI":"10.1038\/scientificamerican08231884-7196asupp","type":"journal-article","created":{"date-parts":[[2015,6,9]],"date-time":"2015-06-09T19:17:23Z","timestamp":1433877443000},"page":"7196-7196","source":"Crossref","is-referenced-by-count":0,"title":["Filtering Cisterns"],"prefix":"10.1038","volume":"18","author":[{"given":"G. D.","family":"Hiscox","sequence":"first","affiliation":[]}],"member":"297","container-title":["Scientific American"],"deposited":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T19:56:01Z","timestamp":1610394961000},"score":15.613381,"resource":{"primary":{"URL":"https:\/\/www.scientificamerican.com\/article\/filtering-cisterns1"}},"issued":{"date-parts":[[1884,8,23]]},"references-count":0,"journal-issue":{"issue":"451supp","published-print":{"date-parts":[[1884,8,23]]}},"alternative-id":["scientificamerican08231884-7196asupp"],"URL":"https:\/\/doi.org\/10.1038\/scientificamerican08231884-7196asupp","ISSN":["0036-8733"],"issn-type":[{"value":"0036-8733","type":"print"}],"published":{"date-parts":[[1884,8,23]]}},{"indexed":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T05:17:33Z","timestamp":1725772653284},"publisher-location":"Dordrecht","reference-count":0,"publisher":"Springer Netherlands","isbn-type":[{"type":"print","value":"9789400707528"},{"type":"electronic","value":"9789400707535"}],"content-domain":{"domain":[],"crossmark-restriction":false},"published-print":{"date-parts":[[2014]]},"DOI":"10.1007\/978-94-007-0753-5_104573","type":"book-chapter","created":{"date-parts":[[2014,3,2]],"date-time":"2014-03-02T22:54:10Z","timestamp":1393800850000},"page":"7196-7196","source":"Crossref","is-referenced-by-count":0,"title":["Work of Art"],"prefix":"10.1007","member":"297","container-title":["Encyclopedia of Quality of Life and Well-Being Research"],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-94-007-0753-5_104573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2014,3,2]],"date-time":"2014-03-02T22:54:54Z","timestamp":1393800894000},"score":15.586172,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-94-007-0753-5_104573"}},"issued":{"date-parts":[[2014]]},"ISBN":["9789400707528","9789400707535"],"references-count":0,"URL":"https:\/\/doi.org\/10.1007\/978-94-007-0753-5_104573","published":{"date-parts":[[2014]]}},{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T18:30:21Z","timestamp":1774895421854,"version":"3.50.1"},"reference-count":0,"publisher":"Universal Write Publications","content-domain":{"domain":[],"crossmark-restriction":false},"abstract":"<jats:p>ABOUT THE BLACK LEXICON SERIES\nThe Black Lexicon is a multi-volume discipline-defining scholarly reference series published by Universal Write Publications. The series is dedicated to establishing, preserving, and advancing the core conceptual language and vocabulary by codifying concepts within pedagogical fields. Each volume provides authoritative definitions, theoretical grounding, and context for the terms, frameworks, and methodologies that shape Black intellectual traditions across time and geography. The Black Lexicon provides comprehensive volumes that document key terms, conceptual paradigms, and foundations across emerging and established disciplines, including adjacent core fields. From colloquialisms in professional knowledge production, activism, and cultural diasporic traditions, each volume is a reference and dictionary text, grounded in research, precision, and historical context. The series addresses a longstanding need in higher education to develop a shared, discipline-specific language grounded in Black thought.<\/jats:p>","DOI":"10.65724\/mvyz7523","type":"book-series","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T17:40:36Z","timestamp":1774892436000},"source":"Crossref","is-referenced-by-count":0,"title":["THE BLACK LEXICON"],"prefix":"10.65724","member":"55258","deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T17:40:36Z","timestamp":1774892436000},"score":14.965089,"resource":{"primary":{"URL":"https:\/\/uwpbooks.com\/product\/the-black-lexicon-series\/"}},"issued":{"date-parts":[[null]]},"references-count":0,"URL":"https:\/\/doi.org\/10.65724\/mvyz7523","ISSN":["3070-7196"],"issn-type":[{"value":"3070-7196","type":"print"}]},{"indexed":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T09:40:09Z","timestamp":1745314809018,"version":"3.40.4"},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"8_Supplement_1","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2025,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>KRAS is altered in approximately 40% of colorectal cancer (CRC), with the KRASG12C mutant (MUT) being particularly notable for its high prevalence in certain cancers that directly activates the MAPK pathway. Sotorasib, an irreversible, selective KRASG12C inhibitor, showed promising antitumor activity in KRASG12C-MUT colorectal cancer. However, despite recent FDA approval, the response rate of Sotorasib monotherapy in CRC remains below 10%. Herein, we aimed to investigate the synergistic efficacy for the combination of a MEK1 inhibitor (Trametinib) and Sotorasib in CRC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>We conducted an integrative analysis of genomic and transcriptomic data, comparing pretreatment cases and those obtained following the development of resistance to Sotorasib. Dose-response curves were generated to determine the IC50 values of Sotorasib and Trametinib in CRC cell lines with distinct mutational profiles: SW837 (KRASG12C) and SW1463 (KRASG12C and MEK1 MUT). To further investigate the effects of the combination compared to the monotherapy of each drug, we performed a series of functional assays by focusing on perturbations within the MAPK\/ERK\/AKT signaling pathway.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Among the 27 patients analyzed, 10 were identified with putative resistance phenotype, of which 9 (37%) had acquired MEK1 mutations or amplifications. The Kaplan-Meier analysis for overall survival in CRC patients harboring wild-type and mutant MEK1. Functional analysis demonstrated a synergic effect of combined Sotorasib and Trametinib treatment in SW837 and SW1463 CRC cell lines. In MTT assays, the combination therapy significantly enhanced cytotoxicity compared to either monotherapy alone. Similarly, colony formation assay revealed a marked reduction in the proliferative capacity of CRC cells when treated with the combination therapy. Mechanistically, combination treatment with Sotorasib and Trametinib led to enhanced inhibition of the MAPK\/ERK\/AKT signaling pathway compared to monotherapy in SW837 and SW1463 cell lines. Furthermore, the introduction of activating mutations in MEK1 (MEK1K57T and MEK1K57N) demonstrated that combinatorial therapies of KRASG12C inhibitor and MEK1 inhibitors could effectively overcome the drug resistance acquired by these activating mutations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>The combined treatment of Sotorasib and a MEK1 inhibitor, Trametinib, exhibit synergistic effects in drug-induced cytotoxicity and inhibition of MAPK pathways in colorectal cancer lines.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Citation Format:<\/jats:title>\n                  <jats:p>Silei Sui, Marwan Fakih, Yuan Li, Caiming Xu, Ajay Goel. Synergistic effect of sotorasib plus trametinib in patients with KRASG12C-mutated metastatic colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 7196.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1158\/1538-7445.am2025-7196","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T23:23:54Z","timestamp":1745277834000},"page":"7196-7196","update-policy":"https:\/\/doi.org\/10.1158\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abstract 7196: Synergistic effect of sotorasib plus trametinib in patients with KRASG12C-mutated metastatic colorectal cancer"],"prefix":"10.1158","volume":"85","author":[{"given":"Silei","family":"Sui","sequence":"first","affiliation":[{"name":"1Beckman Research Institute of The City of Hope, Monrovia, CA;"}]},{"given":"Marwan","family":"Fakih","sequence":"additional","affiliation":[{"name":"2City of Hope Medical Center, Duarte, CA."}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"1Beckman Research Institute of The City of Hope, Monrovia, CA;"}]},{"given":"Caiming","family":"Xu","sequence":"additional","affiliation":[{"name":"1Beckman Research Institute of The City of Hope, Monrovia, CA;"}]},{"given":"Ajay","family":"Goel","sequence":"additional","affiliation":[{"name":"1Beckman Research Institute of The City of Hope, Monrovia, CA;"}]}],"member":"1086","container-title":["Cancer 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Epigraphy"],"prefix":"10.1111","member":"311","language":"en","deposited":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T12:21:04Z","timestamp":1276258864000},"score":14.190587,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1111\/(ISSN)1600-0471"}},"issued":{"date-parts":[[null]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1111\/(issn)1600-0471","ISSN":["0905-7196","1600-0471"],"issn-type":[{"value":"0905-7196","type":"print"},{"value":"1600-0471","type":"electronic"}]},{"indexed":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T01:23:28Z","timestamp":1711157008811},"reference-count":0,"publisher":"American Association for Cancer Research (AACR)","issue":"6_Supplement","content-domain":{"domain":["aacrjournals.org"],"crossmark-restriction":true},"published-print":{"date-parts":[[2024,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Endocrine therapy (ET) is the standard of care for hormone receptor positive (HR+) breast cancer (BC), but ET resistance develops in most patients (pts). One resistance mechanism involves cross talk between the PI3K-AKT-mTOR and estrogen receptor (ER) signaling pathways, resulting in increased ER signaling and tumor proliferation. This is mitigated by mTOR inhibition as demonstrated by improved outcomes with exemestane plus the mTOR inhibitor (mTORi) everolimus in pts with HR+ advanced BC. While PI3K inhibitors (PI3Ki [e.g. alpelisib]) are efficacious in pts with HR+, PIK3CA-mutated BC, resistance can occur due to acquired genomic alterations in the PI3K-AKT-mTOR pathway. Combination therapy that targets a critical downstream node, mTOR, could delay or overcome acquired resistance due to activation of upstream components of the PI3K-AKT-mTOR pathway. nab-Sirolimus is an intravenously administered, albumin-bound nanoparticle form of the mTORi sirolimus, with significantly greater tumor accumulation, mTOR target suppression, and improved antitumor effects than oral mTORis in nonclinical tumor models. We evaluated the antiproliferative and cytotoxic effects of nab-sirolimus in combination with ET or PI3Kis in BC cell lines.<\/jats:p>\n               <jats:p>Methods: HR+, PI3K-mutated BC cell lines (MCF7 or MDA-MB-361) were incubated for 5 days with increasing concentrations of nab-sirolimus and the selective ER degrader fulvestrant. MDA-MB-361 cells or HR-negative (HR\u2212), PI3K-mutated BC cells, MDA-MD-453, were incubated for 5 days with increasing concentrations of nab-sirolimus and PI3K-AKT-mTOR pathway inhibitors gedatolisib or alpelisib. Antiproliferative\/cytotoxic effects of single-agent and combination treatment were assessed via an automated trypan blue exclusion assay.<\/jats:p>\n               <jats:p>Results: Addition of 20 or 80 nM nab-sirolimus to fulvestrant (12.5-500 nM) markedly decreased cell viability and nearly doubled cell death in MCF7 and MDA-MB-361 cells. Antiproliferative effects of low-dose gedatolisib (2.5-10 nM) were enhanced by 61-71% when nab-sirolimus (20 or 80 nM) was added to MDA-MB-453 cells. While low doses (2.5, 5, and 10 nM) of gedatolisib alone led to limited cytotoxicity (4.2-9.6%), up to 48.9% of cell death occurred when 20 or 80 nM nab-sirolimus was added. Results were similar with alpelisib (1 uM) plus nab-sirolimus (20 or 80 nM). Western blot showed increased p4EBP1 in response to fulvestrant or PI3Ki treatment, which was reversed with the addition of nab-sirolimus.<\/jats:p>\n               <jats:p>Conclusions: nab-Sirolimus enhanced the cytotoxic effects of fulvestrant in HR+ BC cells and of PI3Kis in HR+ and HR\u2212 BC cells. Addition of nab-sirolimus to ET or other PI3K-AKT-mTOR pathway inhibitors may overcome mechanisms of resistance; further exploration is warranted to elucidate clinical relevance.<\/jats:p>\n               <jats:p>Citation Format: Khine Nyein Myint, Sean Wallace, Shihe Hou, Maria Zalath, Brian McMorran, Andrew Kwon, Igor Vivanco. Evaluation of nab-sirolimus in combination with fulvestrant or PI3K pathway inhibitors to overcome resistance in breast cancer cell lines [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. 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Western shoulder much more fully preserved, western wall appears to utilize mortared stones, at least in places.  Tile cover of drain preserved only at northern end, otherwise cover has been obliterated.\n          Observations: Exposed most clearly by the removal of deposit 7189.  Tiles, mortar, and concrete were removed by careful excavation with pickaxe on 6 July, 2018.  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