{"status":"ok","message-type":"work-list","message-version":"1.0.0","message":{"facets":{},"total-results":97444,"items":[{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T20:54:37Z","timestamp":1779137677414,"version":"3.51.4"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["221616"],"award-info":[{"award-number":["221616"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["221616"],"award-info":[{"award-number":["221616"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["221616"],"award-info":[{"award-number":["221616"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["221616"],"award-info":[{"award-number":["221616"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["221616"],"award-info":[{"award-number":["221616"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["221616"],"award-info":[{"award-number":["221616"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["221616"],"award-info":[{"award-number":["221616"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["221616"],"award-info":[{"award-number":["221616"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["221616"],"award-info":[{"award-number":["221616"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["221616"],"award-info":[{"award-number":["221616"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["221616"],"award-info":[{"award-number":["221616"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Antimicrob Resist Infect Control"],"abstract":"Abstract<\/jats:title>\n The use of antimicrobials in Thailand has been reported as one of the highest in the world in human and animal sectors. Our engagement project aimed to improve our understanding of the issue of antimicrobial use and antimicrobial resistance (AMR) among adult Thai communities, and co-create locally relevant solutions to AMR, especially those focusing on raising awareness to improve related policies in Thailand.<\/jats:p>\n We conducted a series of online and in-person \u2018conversations\u2019 according to Wellcome\u2019s \u2018Responsive Dialogues\u2019 engagement approach, designed to bring together different voices to understand complex AMR problems and find potential solutions. This approach enabled key AMR stakeholders and policy makers to hear directly from communities and members of the public, and vice versa. Conversations events took place between 25 November 2020 and 8 July 2022, and we engaged 179 AMR key stakeholders and members of the public across Thailand.<\/jats:p>\n The issues found were: there were quite a lot of misunderstandings around antimicrobials and AMR; participants felt that communications and engagement around antimicrobial resistance had limited reach and impact; asking for and taking antibiotics for self-limiting ailments is a social norm in Thailand; and there appeared to be a wide availability of cheap antimicrobials. To mitigate the spread of AMR, participants suggested that the messages around AMR should be tailored to the target audience, there should be more initiatives to increase general health literacy, there should be increased availability of AMR related information at the local level and there should be increased local leadership of AMR mitigation efforts.<\/jats:p>\n \n Trial registration\u00a0<\/jats:bold>\n Thaiclinicaltrials.org registration: TCTR20210528003 (28\/05\/2021).\n <\/jats:p>","DOI":"10.1186\/s13756-024-01416-2","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T08:01:37Z","timestamp":1720080097000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Embedding community and public voices in co-created solutions to mitigate antimicrobial resistance (AMR) in Thailand using the \u2018Responsive Dialogues\u2019 public engagement framework"],"prefix":"10.1186","volume":"13","author":[{"given":"Tassawan","family":"Poomchaichote","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niyada","family":"Kiatying-Angsulee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanpong","family":"Boonthaworn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhensri","family":"Naemiratch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supanat","family":"Ruangkajorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravikanya","family":"Prapharsavat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaiwat","family":"Thirapantu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karnjariya","family":"Sukrung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Direk","family":"Limmathurotsakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Osterrieder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phaik Yeong","family":"Cheah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"issue":"7","key":"1416_CR1","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1179\/2047773215y.0000000030[publishedOnlineFirst:20150907]","volume":"109","author":"F Prestinaci","year":"2015","unstructured":"Prestinaci F, Pezzotti P, Pantosti A. Antimicrobial resistance: a global multifaceted phenomenon. Pathog Glob Health. 2015;109(7):309\u201318. https:\/\/doi.org\/10.1179\/2047773215y.0000000030[publishedOnlineFirst:20150907].","journal-title":"Pathog Glob Health"},{"issue":"3","key":"1416_CR2","doi-asserted-by":"publisher","first-page":"482","DOI":"10.3934\/microbiol.2018.3.482[publishedOnlineFirst:20180626]","volume":"4","author":"WC Reygaert","year":"2018","unstructured":"Reygaert WC. An overview of the antimicrobial resistance mechanisms of bacteria. AIMS Microbiol. 2018;4(3):482\u2013501. https:\/\/doi.org\/10.3934\/microbiol.2018.3.482[publishedOnlineFirst:20180626].","journal-title":"AIMS Microbiol"},{"key":"1416_CR3","doi-asserted-by":"publisher","first-page":"106103","DOI":"10.1016\/j.ejps.2021.106103","volume":"170","author":"T Pulingam","year":"2022","unstructured":"Pulingam T, Parumasivam T, Gazzali AM, et al. Antimicrobial resistance: Prevalence, economic burden, mechanisms of resistance and strategies to overcome. Eur J Pharm Sci. 2022;170:106103. https:\/\/doi.org\/10.1016\/j.ejps.2021.106103.","journal-title":"Eur J Pharm Sci"},{"issue":"10325","key":"1416_CR4","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","volume":"399","author":"CJL Murray","year":"2022","unstructured":"Murray CJL, Ikuta KS, Sharara F, et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399(10325):629\u201355. https:\/\/doi.org\/10.1016\/S0140-6736(21)02724-0.","journal-title":"Lancet"},{"issue":"1","key":"1416_CR5","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12992-023-00930-z","volume":"19","author":"YA Adebisi","year":"2023","unstructured":"Adebisi YA. Balancing the risks and benefits of antibiotic use in a globalized world: the ethics of antimicrobial resistance. Glob Health. 2023;19(1):27. https:\/\/doi.org\/10.1186\/s12992-023-00930-z.","journal-title":"Glob Health"},{"key":"1416_CR6","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/978-3-030-27874-8_262020","volume-title":"Ethics and Drug Resistance: Collective Responsibility for Global Public Health","author":"J Littmann","year":"2020","unstructured":"Littmann J, Viens AM, Silva DS. The super-wicked problem of antimicrobial resistance. In: Jamrozik E, Selgelid M, editors. Ethics and Drug Resistance: Collective Responsibility for Global Public Health. Cham: Springer International Publishing; 2020. p. 421\u201343. https:\/\/doi.org\/10.1007\/978-3-030-27874-8_262020."},{"key":"1416_CR7","doi-asserted-by":"publisher","unstructured":"Varadan SR, Chandler CIR, Weed K, et al. A just transition for antimicrobial resistance: planning for an equitable and sustainable future with antimicrobial resistance. Lancet. 2023. https:\/\/doi.org\/10.1016\/S0140-6736(23)01687-2.","DOI":"10.1016\/S0140-6736(23)01687-2"},{"issue":"4","key":"1416_CR8","doi-asserted-by":"publisher","first-page":"e012874","DOI":"10.1136\/bmjgh-2023-012874","volume":"9","author":"P Sunil","year":"2024","unstructured":"Sunil P, Bipin A, Tess J, et al. Interventions to address antimicrobial resistance: an ethical analysis of key tensions and how they apply in low- income and middle-income countries. BMJ Glob Health. 2024;9(4):e012874. https:\/\/doi.org\/10.1136\/bmjgh-2023-012874.","journal-title":"BMJ Glob Health"},{"key":"1416_CR9","unstructured":"The World Bank. The World Bank in Thailand 2023. [Available from: https:\/\/www.worldbank.org\/en\/country\/thailand Accessed 22 Apr 2024]."},{"key":"1416_CR10","unstructured":"Worldometer. Thailand Population 2023 [Available from: https:\/\/www.worldometers.info\/world-population\/thailand-population\/. Accessed 22 April 2024]."},{"key":"1416_CR11","doi-asserted-by":"publisher","unstructured":"Lim C, Takahashi E, Hongsuwan M, et al. Epidemiology and burden of multidrug-resistant bacterial infection in a developing country. Elife 2016;5 https:\/\/doi.org\/10.7554\/eLife.18082 [published Online First: 2016\/09\/07]","DOI":"10.7554\/eLife.18082"},{"issue":"9","key":"1416_CR12","doi-asserted-by":"publisher","first-page":"ofac305","DOI":"10.1093\/ofid\/ofac305","volume":"9","author":"C Lim","year":"2022","unstructured":"Lim C, Teparrukkul P, Nuntalohit S, et al. Excess mortality attributable to hospital-acquired antimicrobial-resistant infections: a 2-year prospective surveillance study in Northeast Thailand. Open Forum Infect Dis. 2022;9(9):ofac305. https:\/\/doi.org\/10.1093\/ofid\/ofac305. published Online First: 20220620.","journal-title":"Open Forum Infect Dis"},{"issue":"8","key":"1416_CR13","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1093\/jac\/dkz185","volume":"74","author":"D Limmathurotsakul","year":"2019","unstructured":"Limmathurotsakul D, Sandoe JAT, Barrett DC, et al. \u201cAntibiotic footprint\u201d as a communication tool to aid reduction of antibiotic consumption. J Antimicrob Chemother. 2019;74(8):2122\u20137. https:\/\/doi.org\/10.1093\/jac\/dkz185. published Online First: 2019\/05\/11.","journal-title":"J Antimicrob Chemother"},{"issue":"2","key":"1416_CR14","doi-asserted-by":"publisher","first-page":"94","DOI":"10.2471\/BLT.17.195834[publishedOnlineFirst:2018\/02\/07]","volume":"96","author":"G Wongsuvan","year":"2018","unstructured":"Wongsuvan G, Wuthiekanun V, Hinjoy S, et al. Antibiotic use in poultry: a survey of eight farms in Thailand. Bull World Health Organ. 2018;96(2):94\u2013100. https:\/\/doi.org\/10.2471\/BLT.17.195834[publishedOnlineFirst:2018\/02\/07].","journal-title":"Bull World Health Organ"},{"key":"1416_CR15","unstructured":"World Health Organization. WHO report on surveillance of antibiotic consumption: 2016\u20132018 early implementation. 2018."},{"key":"1416_CR16","unstructured":"Nundy M, Bhatt P (2022). The Health System in the Kingdom of Thailand: Reforms, achievements, and challenges. (CSEP Working Paper 45). Centre for Social and Economic Progress. Available from: https:\/\/csep.org\/working-paper\/health-system-in-the-kingdom-of-thailand-reforms-acheivements-and-challenges\/2022."},{"key":"1416_CR17","unstructured":"World Health Organization. Primary health care systems (PRIMASYS): case study from Thailand, abridged version. 2017. Available from: https:\/\/ahpsr.who.int\/publications\/i\/item\/primasys-abridged-case-study-from-thailand2017."},{"key":"1416_CR18","doi-asserted-by":"publisher","unstructured":"Siltrakool B, Berrou I, Griffiths D, et al. Antibiotics' use in Thailand: community pharmacists' knowledge, attitudes and practices. Antibiotics (Basel) 2021;10(2). https:\/\/doi.org\/10.3390\/antibiotics10020137 [published Online First: 20210131]","DOI":"10.3390\/antibiotics10020137"},{"key":"1416_CR19","first-page":"S72","volume":"29","author":"S Pumtong","year":"2020","unstructured":"Pumtong S, Suwannaprom P, Suttajit S, et al. Irrational antibiotic use and distribution in the Thai community: a complex situation in need of integrative solution - \u0e2a\u0e16\u0e32\u0e19\u0e01\u0e32\u0e23\u0e13\u0e4c\u0e01\u0e32\u0e23\u0e43\u0e0a\u0e49\u0e41\u0e25\u0e30\u0e01\u0e23\u0e30\u0e08\u0e32\u0e22\u0e22\u0e32\u0e1b\u0e0f\u0e34\u0e0a\u0e35\u0e27\u0e19\u0e30\u0e43\u0e19\u0e0a\u0e38\u0e21\u0e0a\u0e19\u0e02\u0e2d\u0e07\u0e44\u0e17\u0e22: \u0e1b\u0e31\u0e0d\u0e2b\u0e32\u0e0b\u0e31\u0e1a\u0e0b\u0e49\u0e2d\u0e19\u0e17\u0e35\u0e48\u0e15\u0e49\u0e2d\u0e07\u0e08\u0e31\u0e14\u0e01\u0e32\u0e23\u0e41\u0e1a\u0e1a\u0e1a\u0e39\u0e23\u0e13\u0e32\u0e01\u0e32\u0e23. J Health Sci Thailand. 2020;29:S72\u201381.","journal-title":"J Health Sci Thailand"},{"issue":"4","key":"1416_CR20","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.ajic.2017.09.022","volume":"46","author":"N Sutthiruk","year":"2018","unstructured":"Sutthiruk N, Considine J, Hutchinson A, et al. Thai clinicians\u2019 attitudes toward antimicrobial stewardship programs. Am J Infect Control. 2018;46(4):425\u201330. https:\/\/doi.org\/10.1016\/j.ajic.2017.09.022.","journal-title":"Am J Infect Control"},{"issue":"4","key":"1416_CR21","doi-asserted-by":"publisher","first-page":"e0298972","DOI":"10.1371\/journal.pone.0298972","volume":"19","author":"M Sunpuwan","year":"2024","unstructured":"Sunpuwan M, Punpuing S, Jaruruengpaisan W, et al. Understanding antibiotic use in the community setting in Thailand: Does communication matter? PLoS ONE. 2024;19(4):e0298972. https:\/\/doi.org\/10.1371\/journal.pone.0298972.","journal-title":"PLoS ONE"},{"issue":"1","key":"1416_CR22","doi-asserted-by":"publisher","first-page":"2298940","DOI":"10.1080\/17441692.2023.2298940","volume":"19","author":"N Alhusein","year":"2024","unstructured":"Alhusein N, Charoenboon N, Wichuwaranan K, et al. The unseen use of antimicrobials: Drivers of human antibiotic use in a community in Thailand and implications for surveillance. Glob Public Health. 2024;19(1):2298940. https:\/\/doi.org\/10.1080\/17441692.2023.2298940.","journal-title":"Glob Public Health"},{"key":"1416_CR23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2147\/dhps.S339808","volume":"14","author":"TZ Lin","year":"2022","unstructured":"Lin TZ, Jayasvasti I, Tiraphat S, et al. The predictors influencing the rational use of antibiotics among public sector: a community-based survey in Thailand. Drug Healthc Patient Saf. 2022;14:27\u201336. https:\/\/doi.org\/10.2147\/dhps.S339808.","journal-title":"Drug Healthc Patient Saf"},{"issue":"8","key":"1416_CR24","doi-asserted-by":"publisher","first-page":"e0220990","DOI":"10.1371\/journal.pone.0220990","volume":"14","author":"S Chanvatik","year":"2019","unstructured":"Chanvatik S, Kosiyaporn H, Lekagul A, et al. Knowledge and use of antibiotics in Thailand: A 2017 national household survey. PLoS ONE. 2019;14(8):e0220990. https:\/\/doi.org\/10.1371\/journal.pone.0220990. published Online First: 2019\/08\/10.","journal-title":"PLoS ONE"},{"issue":"1","key":"1416_CR25","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1186\/s12889-021-12237-y","volume":"21","author":"V Tangcharoensathien","year":"2021","unstructured":"Tangcharoensathien V, Chanvatik S, Kosiyaporn H, et al. Population knowledge and awareness of antibiotic use and antimicrobial resistance: results from national household survey 2019 and changes from 2017. BMC Pub Health. 2021;21(1):2188. https:\/\/doi.org\/10.1186\/s12889-021-12237-y.","journal-title":"BMC Pub Health"},{"key":"1416_CR26","doi-asserted-by":"publisher","unstructured":"Niyomyart A, Chow SK, Bualoy W, et al. Antibiotic knowledge, antibiotic resistance knowledge, and antibiotic use: A cross-sectional study among community members of Bangkok in Thailand. Antibiotics. 2023;12(8):1312. https:\/\/doi.org\/10.3390\/antibiotics12081312.","DOI":"10.3390\/antibiotics12081312"},{"issue":"4","key":"1416_CR27","doi-asserted-by":"publisher","first-page":"e001590","DOI":"10.1136\/bmjgh-2019-001590","volume":"4","author":"L Denyer Willis","year":"2019","unstructured":"Denyer Willis L, Chandler C. Quick fix for care, productivity, hygiene and inequality: reframing the entrenched problem of antibiotic overuse. BMJ Glob Health. 2019;4(4):e001590. https:\/\/doi.org\/10.1136\/bmjgh-2019-001590. published Online First: 2019\/09\/10.","journal-title":"BMJ Glob Health"},{"key":"1416_CR28","doi-asserted-by":"publisher","unstructured":"Lambraki IA, Chadag MV, Cousins M, et al. Factors impacting antimicrobial resistance in the South East Asian food system and potential places to intervene: A participatory, one health study. Front Microbiol 2023;13 https:\/\/doi.org\/10.3389\/fmicb.2022.992507","DOI":"10.3389\/fmicb.2022.992507"},{"key":"1416_CR29","unstructured":"Wellcome Trust (2021). Responsive Dialogues on drug resistant infections Version 2 2021. Available from: https:\/\/cms.wellcome.org\/sites\/default\/files\/2021-02\/responsive-dialogues-drug-resistant-infections-tollkit.pdf2021."},{"key":"1416_CR30","doi-asserted-by":"publisher","first-page":"188","DOI":"10.12688\/wellcomeopenres.17066.2","volume":"6","author":"T Poomchaichote","year":"2021","unstructured":"Poomchaichote T, Osterrieder A, Prapharsavat R, et al. \u201cAMR Dialogues\u201d: a public engagement initiative to shape policies and solutions on antimicrobial resistance (AMR) in Thailand. Wellcome Open Res. 2021;6:188. https:\/\/doi.org\/10.12688\/wellcomeopenres.17066.2. published Online First: 20220407.","journal-title":"Wellcome Open Res"},{"key":"1416_CR31","unstructured":"The Coordination and Integration Committee on Antimicrobial Resistance 2016 Thailand National Strategic Plan on Antimicrobial Resistance 2017\u20132021. Available from: https:\/\/rr-asia.woah.org\/wp-content\/uploads\/2020\/03\/thailand_thailands-national-strategic-plan-on-amr-2017-2021.pdf."},{"issue":"9","key":"1416_CR32","doi-asserted-by":"publisher","first-page":"661","DOI":"10.2471\/blt.20.280644","volume":"99","author":"N Sumpradit","year":"2021","unstructured":"Sumpradit N, Wongkongkathep S, Malathum K, et al. Thailand\u2019s national strategic plan on antimicrobial resistance: progress and challenges. Bull World Health Organ. 2021;99(9):661\u201373. https:\/\/doi.org\/10.2471\/blt.20.280644. published Online First: 20210701.","journal-title":"Bull World Health Organ"},{"key":"1416_CR33","unstructured":"Poomchaichote T, Praphasavat R. Embedding public and community voices in shaping Thailand\u2019s National Strategic Plan on Antimicrobial Resistance. 2022. Available from: https:\/\/youtu.be\/DPc9oCqwJCo2022."},{"key":"1416_CR34","unstructured":"Poomchaichote T, Boonthaworn K, Naemiratch B, et al. Summary of key findings of Antimicrobial Resistance Dialogues in Thailand (\u0e2a\u0e23\u0e38\u0e1b\u0e2a\u0e32\u0e23\u0e30\u0e2a\u0e33\u0e04\u0e31\u0e0d\u0e08\u0e32\u0e01\u0e42\u0e04\u0e23\u0e07\u0e01\u0e32\u0e23\u0e40\u0e2a\u0e27\u0e19\u0e32\u0e40\u0e23\u0e37\u0e48\u0e2d\u0e07\u0e40\u0e0a\u0e37\u0e49\u0e2d\u0e14\u0e37\u0e49\u0e2d\u0e22\u0e32\u0e43\u0e19\u0e1b\u0e23\u0e30\u0e40\u0e17\u0e28\u0e44\u0e17\u0e22) (1.0 date 20230611). 2023. 10.5281\/zenodo.8024656. Available from: https:\/\/zenodo.org\/records\/8024656."},{"key":"1416_CR35","unstructured":"Sumpradit N., Krobanan K., Youngkong S., et al. (2019). Mapping and prioritization of research on antimicrobial resistance in Thailand. Food and Drug Administration, Ministry of Public Health. Available from: https:\/\/amrthailand.net\/Report2019."},{"key":"1416_CR36","doi-asserted-by":"publisher","unstructured":"Osterrieder A, Ruangkajorn S, Cheah PY. Terms of reference for the Bangkok Health Research and Ethics Interest Group (HREIG). 2020. Zenodo. https:\/\/doi.org\/10.5281\/zenodo.4312633.","DOI":"10.5281\/zenodo.4312633"},{"key":"1416_CR37","unstructured":"Thirapantu C, Sukrung K, Poomchaichote T, et al. Agenda of Antimicrobial Resistance (AMR) Dialogues in the North-eastern region of Thailand (1.0). 2023. 10.5281\/zenodo.8314771. Available from: https:\/\/doi.org\/10.5281\/zenodo.8314771."},{"issue":"4","key":"1416_CR38","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1080\/2159676X.2019.1628806","volume":"11","author":"V Braun","year":"2019","unstructured":"Braun V, Clarke V. Reflecting on reflexive thematic analysis. Qual Res Sport Exerc Health. 2019;11(4):589\u201397. https:\/\/doi.org\/10.1080\/2159676X.2019.1628806.","journal-title":"Qual Res Sport Exerc Health"},{"key":"1416_CR39","doi-asserted-by":"publisher","first-page":"j3415","DOI":"10.1136\/bmj.j2423","volume":"358","author":"N Sumpradit","year":"2017","unstructured":"Sumpradit N, Wongkongkathep S, Poonpolsup S, et al. New chapter in tackling antimicrobial resistance in Thailand. BMJ. 2017;358:j3415. https:\/\/doi.org\/10.1136\/bmj.j2423. published Online First: 2017\/09\/07.","journal-title":"BMJ"},{"issue":"sp1","key":"1416_CR40","first-page":"47","volume":"6","author":"Y Jeena","year":"2018","unstructured":"Jeena Y, Jeena R. \u201cBa Worn Santisook Project\u201d\u202f: A participatory model of Home, Temple, School for promote morality of 12 values, Chiang Mai. J MCU Peace Stud. 2018;6(sp1):47\u201360.","journal-title":"J MCU Peace Stud"},{"issue":"2","key":"1416_CR41","doi-asserted-by":"publisher","first-page":"502","DOI":"10.14456\/psruhss.2021.38","volume":"15","author":"Y Phongrod","year":"2021","unstructured":"Phongrod Y, Limsiriwong S, Tana S, et al. Model development of participatory process in moving forward B.W.R. principle (Home, Temple, School) in order to build strong and sustainable communities: case Study of Ban Khlong Toei Community, Bueng Kok Sub-district, Bangrakam District, Phitsanulok Province. Human Soc Sci J Pibulsongkram Rajabhat University. 2021;15(2):502\u201316. https:\/\/doi.org\/10.14456\/psruhss.2021.38.","journal-title":"Human Soc Sci J Pibulsongkram Rajabhat University"},{"issue":"7","key":"1416_CR42","doi-asserted-by":"publisher","first-page":"472","DOI":"10.2471\/BLT.14.030714","volume":"92","author":"S Wibulpolprasert","year":"2014","unstructured":"Wibulpolprasert S, Fleck F. Thailand\u2019s health ambitions pay off. Bull World Health Organ. 2014;92(7):472\u20133. https:\/\/doi.org\/10.2471\/BLT.14.030714.","journal-title":"Bull World Health Organ"},{"issue":"1","key":"1416_CR43","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1186\/s12889-019-7300-5","volume":"19","author":"M Sunpuwan","year":"2019","unstructured":"Sunpuwan M, Punpuing S, Jaruruengpaisan W, et al. What is in the drug packet?: access and use of non-prescribed poly-pharmaceutical packs (Yaa Chud) in the community in Thailand. BMC Pub Health. 2019;19(1):971. https:\/\/doi.org\/10.1186\/s12889-019-7300-5.","journal-title":"BMC Pub Health"},{"issue":"2","key":"1416_CR44","doi-asserted-by":"publisher","first-page":"NP2480","DOI":"10.1177\/1010539513479968","volume":"27","author":"S Arparsrithongsagul","year":"2015","unstructured":"Arparsrithongsagul S, Kulsomboon V, Zuckerman IH. Multidisciplinary perspective intervention with community involvement to decrease antibiotic sales in village groceries in Thailand. Asia Pac J Public Health. 2015;27(2):NP2480\u20138. https:\/\/doi.org\/10.1177\/1010539513479968.","journal-title":"Asia Pac J Public Health"},{"issue":"3","key":"1416_CR45","first-page":"270","volume":"99","author":"S Khamsarn","year":"2016","unstructured":"Khamsarn S, Nampoonsak Y, Busamaro S, et al. Epidemiology of antibiotic use and antimicrobial resistance in selected communities in Thailand. J Med Assoc Thai. 2016;99(3):270\u20135.","journal-title":"J Med Assoc Thai"},{"issue":"11","key":"1416_CR46","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.1080\/17441692.2021.2003839","volume":"17","author":"J Mitchell","year":"2022","unstructured":"Mitchell J, Cooke P, Ahorlu C, et al. Community engagement: The key to tackling antimicrobial resistance (AMR) across a One Health context? Glob Public Health. 2022;17(11):2647\u201364. https:\/\/doi.org\/10.1080\/17441692.2021.2003839.","journal-title":"Glob Public Health"},{"issue":"11","key":"1416_CR47","doi-asserted-by":"publisher","first-page":"e0225172","DOI":"10.1371\/journal.pone.0225172","volume":"14","author":"S Chanvatik","year":"2019","unstructured":"Chanvatik S, Donnua S, Lekagul A, et al. Antibiotic use in mandarin production (Citrus reticulata Blanco) in major mandarin-producing areas in Thailand: A survey assessment. PLoS ONE. 2019;14(11):e0225172. https:\/\/doi.org\/10.1371\/journal.pone.0225172. published Online First: 20191113.","journal-title":"PLoS ONE"},{"key":"1416_CR48","unstructured":"Thamlikitkul V, Rattanaumpawan P, Boonyasiri A, et al. Operational actions of the Thailand antimicrobial resistance (AMR) containment and prevention program in response to the World Health Organization (WHO) Global Action Plan on AMR. J Health Syst Res. 2017;11(4):453\u201370."},{"issue":"8","key":"1416_CR49","doi-asserted-by":"publisher","first-page":"e028224","DOI":"10.1136\/bmjopen-2018-028224","volume":"9","author":"MJ Haenssgen","year":"2019","unstructured":"Haenssgen MJ, Charoenboon N, Zanello G, et al. Antibiotic knowledge, attitudes and practices: new insights from cross-sectional rural health behaviour surveys in low-income and middle-income South-East Asia. BMJ Open. 2019;9(8):e028224. https:\/\/doi.org\/10.1136\/bmjopen-2018-028224. published Online First: 20190820.","journal-title":"BMJ Open"},{"key":"1416_CR50","doi-asserted-by":"publisher","unstructured":"Prapharsavat R, Lim C, Sunthornsut P, et al. The utility of an AMR dictionary as an educational tool to improve public understanding of antimicrobial resistance [version 1; peer review: 1 approved]. Wellcome Open Res 2021;6(113) https:\/\/doi.org\/10.12688\/wellcomeopenres.16488.1","DOI":"10.12688\/wellcomeopenres.16488.1"},{"issue":"3","key":"1416_CR51","doi-asserted-by":"publisher","first-page":"e001239","DOI":"10.1136\/bmjgh-2018-001239","volume":"4","author":"B Huttner","year":"2019","unstructured":"Huttner B, Saam M, Moja L, et al. How to improve antibiotic awareness campaigns: findings of a WHO global survey. BMJ Glob Health. 2019;4(3):e001239. https:\/\/doi.org\/10.1136\/bmjgh-2018-001239.","journal-title":"BMJ Glob Health"},{"issue":"4","key":"1416_CR52","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1002\/jppr.1801","volume":"52","author":"P Phueanpinit","year":"2022","unstructured":"Phueanpinit P, Siriwattanasakul N, Tichakorn P, et al. Knowledge and perceptions of outpatients regarding upper respiratory tract infections and awareness of an Antibiotics Smart Use campaign in Thailand. J Pharm Pract Res. 2022;52(4):294\u2013302. https:\/\/doi.org\/10.1002\/jppr.1801.","journal-title":"J Pharm Pract Res"},{"issue":"4","key":"1416_CR53","doi-asserted-by":"publisher","first-page":"216","DOI":"10.5281\/zenodo.8314771","volume":"35","author":"S Arnstein","year":"1969","unstructured":"Arnstein S. A ladder of citizen participation. J Am Plann Assoc. 1969;35(4):216\u201324. https:\/\/doi.org\/10.5281\/zenodo.8314771.","journal-title":"J Am Plann Assoc"},{"key":"1416_CR54","unstructured":"Health Policy and Systems Research on Antimicrobial Resistance Network (2021). Thailand\u2019s One Health Report on antimicrobial consumption and antimicrobial resistance in 2019. Available from: https:\/\/ihppthaigov.net\/publication\/thailands-one-health-report-on-antimicrobial-consumption-and-antimicrobial-resistance-in-20212021."},{"key":"1416_CR55","doi-asserted-by":"publisher","unstructured":"Tompson AC, Chandler CI (2021). Addressing antibiotic use: insights from social science around the world. Project report. London School of Hygiene & Tropical Medicine. Available from: https:\/\/doi.org\/10.17037\/PUBS.04659562 2021.","DOI":"10.17037\/PUBS.04659562"},{"issue":"1","key":"1416_CR56","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1186\/s12889-020-09033-5","volume":"20","author":"R King","year":"2020","unstructured":"King R, Hicks J, Rassi C, et al. A process for developing a sustainable and scalable approach to community engagement: community dialogue approach for addressing the drivers of antibiotic resistance in Bangladesh. BMC Public Health. 2020;20(1):950. https:\/\/doi.org\/10.1186\/s12889-020-09033-5.","journal-title":"BMC Public Health"},{"key":"1416_CR57","doi-asserted-by":"publisher","unstructured":"Mpundu M, Mathew P, Chanda R, et al. What would it take to move the global AMR agenda forward in the global South? 2023. https:\/\/doi.org\/10.1093\/oso\/9780192899477.003.0007 . Accessed 16 Apr 2024. Access 2023.","DOI":"10.1093\/oso\/9780192899477.003.0007"},{"issue":"12","key":"1416_CR58","doi-asserted-by":"publisher","first-page":"905","DOI":"10.2471\/blt.12.105445","volume":"90","author":"N Sumpradit","year":"2012","unstructured":"Sumpradit N, Chongtrakul P, Anuwong K, et al. Antibiotics Smart Use: a workable model for promoting the rational use of medicines in Thailand. Bull World Health Organ. 2012;90(12):905\u201313. https:\/\/doi.org\/10.2471\/blt.12.105445.","journal-title":"Bull World Health Organ"},{"issue":"4","key":"1416_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.infpip.2023.100315","volume":"5","author":"N Shamas","year":"2023","unstructured":"Shamas N, Stokle E, Ashiru-Oredope D, et al. Challenges of implementing antimicrobial stewardship tools in Low to Middle Income Countries (LMICs). Infect Prev Pract. 2023;5(4): 100315. https:\/\/doi.org\/10.1016\/j.infpip.2023.100315.","journal-title":"Infect Prev Pract"},{"issue":"4","key":"1416_CR60","doi-asserted-by":"publisher","first-page":"100314","DOI":"10.1016\/j.infpip.2023.100314","volume":"5","author":"H Rickard","year":"2023","unstructured":"Rickard H, Watkin S, Baldwin N, et al. Antimicrobial resistance as a super wicked problem: how do we engage the public to be part of the solution. Infect Prev Pract. 2023;5(4):100314. https:\/\/doi.org\/10.1016\/j.infpip.2023.100314.","journal-title":"Infect Prev Pract"},{"key":"1416_CR61","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jiph.2023.11.008","volume":"16","author":"AS Mukherjee","year":"2023","unstructured":"Mukherjee AS, Sahay S. Systems thinking based approaches to engage with health inequities shaping Antimicrobial Resistance in low and lower-middle-income countries. J Infect Pub Heal. 2023;16:129\u201333. https:\/\/doi.org\/10.1016\/j.jiph.2023.11.008.","journal-title":"J Infect Pub Heal"}],"container-title":["Antimicrobial Resistance & Infection Control"],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13756-024-01416-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13756-024-01416-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13756-024-01416-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T08:03:13Z","timestamp":1720080193000},"score":10.190976,"resource":{"primary":{"URL":"https:\/\/aricjournal.biomedcentral.com\/articles\/10.1186\/s13756-024-01416-2"}},"issued":{"date-parts":[[2024,7,4]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1416"],"URL":"https:\/\/doi.org\/10.1186\/s13756-024-01416-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.10.06.23296658","asserted-by":"object"}]},"ISSN":["2047-2994"],"issn-type":[{"value":"2047-2994","type":"electronic"}],"published":{"date-parts":[[2024,7,4]]},"assertion":[{"value":"14 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"71"},{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:48:12Z","timestamp":1774522092580,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Wellcome","award":["226699\/Z\/22\/Z"],"award-info":[{"award-number":["226699\/Z\/22\/Z"]}]},{"name":"Wellcome","award":["226699\/Z\/22\/Z"],"award-info":[{"award-number":["226699\/Z\/22\/Z"]}]},{"name":"Wellcome","award":["226699\/Z\/22\/Z"],"award-info":[{"award-number":["226699\/Z\/22\/Z"]}]},{"name":"Wellcome","award":["226699\/Z\/22\/Z"],"award-info":[{"award-number":["226699\/Z\/22\/Z"]}]},{"name":"Wellcome","award":["226699\/Z\/22\/Z"],"award-info":[{"award-number":["226699\/Z\/22\/Z"]}]},{"name":"Wellcome","award":["226699\/Z\/22\/Z"],"award-info":[{"award-number":["226699\/Z\/22\/Z"]}]},{"name":"Wellcome","award":["226699\/Z\/22\/Z"],"award-info":[{"award-number":["226699\/Z\/22\/Z"]}]},{"name":"Wellcome","award":["226699\/Z\/22\/Z"],"award-info":[{"award-number":["226699\/Z\/22\/Z"]}]},{"name":"Wellcome","award":["226699\/Z\/22\/Z"],"award-info":[{"award-number":["226699\/Z\/22\/Z"]}]},{"name":"Wellcome","award":["226699\/Z\/22\/Z"],"award-info":[{"award-number":["226699\/Z\/22\/Z"]}]},{"name":"Wellcome","award":["226699\/Z\/22\/Z"],"award-info":[{"award-number":["226699\/Z\/22\/Z"]}]},{"name":"Wellcome","award":["226699\/Z\/22\/Z"],"award-info":[{"award-number":["226699\/Z\/22\/Z"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Public Health"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Schools are called upon to use data-informed practice to support student health and well-being. However, they face implementation challenges including data accessibility and literacy. Data dashboards offer a method to address these challenges, thereby promoting data-informed practice. This paper reports on a pilot of The School Health Research Network Data Dashboard with secondary schools.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The Dashboard was piloted by three secondary schools (recruited by size; free school meal entitlement) in Wales, UK. Interviews with school staff (\n N<\/jats:italic>\n \u2009=\u20097) and public health practitioners (\n N<\/jats:italic>\n \u2009=\u20096) were conducted. Data were analysed thematically. Research design, including interview questions, analytical interpretation and code, and theme development utilised Complex Adaptive Systems as the conceptual framework.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n School staff had access to multiple data sets for health promotion but often lacked the time and capacity to utilise them. The Dashboard was perceived to be a user-friendly method of enhancing data accessibility and usability in secondary schools, providing appropriate training and guidance for school staff was available to avoid data misinterpretation. National roll-out of the Dashboard was supported if it aligned with the needs of schools and the wider education system.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The Dashboard presents an opportunity for data-informed health and well-being practice and could also support schools to meet education system requirements, providing school staff receive appropriate training. This paper offers novel practical, policy-relevant insights on the interaction of digital dashboards with school systems, capacity constraints, and professional learning needs and valuable insights for public health systems seeking to support data-informed practice in educational settings.<\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s12889-026-26647-3","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T07:25:10Z","timestamp":1771399510000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Piloting a data dashboard to support data-informed health promotion in secondary schools: qualitative analysis of stakeholder interviews"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-6614","authenticated-orcid":false,"given":"J.","family":"Van Godwin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1284-9645","authenticated-orcid":false,"given":"S.","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3388-8902","authenticated-orcid":false,"given":"H.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4671-2797","authenticated-orcid":false,"given":"N.","family":"Page","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7949-4039","authenticated-orcid":false,"given":"M.","family":"Svobodova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3380-4966","authenticated-orcid":false,"given":"M.","family":"Boffey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9484-1729","authenticated-orcid":false,"given":"F.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0254-3397","authenticated-orcid":false,"given":"Y.","family":"Shenderovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8976-9825","authenticated-orcid":false,"given":"R.","family":"Bevan-Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3589-3681","authenticated-orcid":false,"given":"S.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6215-0870","authenticated-orcid":false,"given":"J.","family":"Segrott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"issue":"9801","key":"26647_CR1","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1016\/S0140-6736(11)60827-1","volume":"378","author":"C Kieling","year":"2011","unstructured":"Kieling C, Baker-Henningham H, Belfer M, Conti G, Ertem I, Omigbodun O, et al. Child and adolescent mental health worldwide: evidence for action. Lancet. 2011;378(9801):1515\u201325.","journal-title":"Lancet"},{"key":"26647_CR2","doi-asserted-by":"publisher","first-page":"h4300","DOI":"10.1136\/bmj.h4300","volume":"351","author":"WM Were","year":"2015","unstructured":"Were WM, Daelmans B, Bhutta Z, Duke T, Bahl R, Boschi-Pinto C, et al. Children\u2019s health priorities and interventions. BMJ. 2015;351:h4300.","journal-title":"BMJ"},{"key":"26647_CR3","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.healthplace.2012.12.001","volume":"21","author":"C Bonell","year":"2013","unstructured":"Bonell C, Parry W, Wells H, Jamal F, Fletcher A, Harden A, et al. The effects of the school environment on student health: A systematic review of multi-level studies. Health Place. 2013;21:180\u201391.","journal-title":"Health Place"},{"key":"26647_CR4","doi-asserted-by":"publisher","first-page":"g3078","DOI":"10.1136\/bmj.g3078","volume":"348","author":"C Bonell","year":"2014","unstructured":"Bonell C, Humphrey N, Fletcher A, Moore L, Anderson R, Campbell R. Why schools should promote students\u2019 health and wellbeing. BMJ. 2014;348:g3078.","journal-title":"BMJ"},{"issue":"10","key":"26647_CR5","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1111\/j.1746-1561.2011.00632.x","volume":"81","author":"CE Basch","year":"2011","unstructured":"Basch CE. Healthier students are better learners: a missing link in school reforms to close the achievement gap. J Sch Health. 2011;81(10):593\u20138.","journal-title":"J Sch Health"},{"key":"26647_CR6","unstructured":"WHO. Promoting health through schools: report of a WHO expert committee on comprehensive school health education and promotion. World Health Organization Technical Report Series no. 870. Geneva; 1997. https:\/\/www.who.int\/publications\/i\/item\/WHO-TRS-870."},{"key":"26647_CR7","unstructured":"WHO. Making every school a health-promoting school: implementation guidance. World Health Organization. Geneva; 2021. https:\/\/www.who.int\/publications\/i\/item\/9789240025073."},{"key":"26647_CR8","doi-asserted-by":"publisher","DOI":"10.4324\/9780429280696","volume-title":"The educators\u2019 guide to whole-school wellbeing: A practical guide to getting started, best-practice process and effective implementation","author":"DM Quinlan","year":"2020","unstructured":"Quinlan DM, Hone LC. The educators\u2019 guide to whole-school wellbeing: A practical guide to getting started, best-practice process and effective implementation. London: Routledge; 2020."},{"issue":"1","key":"26647_CR9","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1186\/s12889-019-7510-x","volume":"19","author":"PE Jessiman","year":"2019","unstructured":"Jessiman PE, Campbell R, Jago R, Van Sluijs EMF, Newbury-Birch D. A qualitative study of health promotion in academy schools in England. BMC Public Health. 2019;19(1):1186.","journal-title":"BMC Public Health"},{"issue":"4","key":"26647_CR10","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1002\/berj.3861","volume":"49","author":"SJ Long","year":"2023","unstructured":"Long SJ, Hawkins J, Murphy S, Moore G. School health and wellbeing and National education system reform: A qualitative study. Br Educ Res J. 2023;49(4):674\u201392.","journal-title":"Br Educ Res J"},{"key":"26647_CR11","doi-asserted-by":"publisher","unstructured":"Chambers S, Haughton D, Mabelis J, Brown J, Inchley J. Feasibility of using health and wellbeing data for school planning: the SHINE pilot in Scotland. Health Promot Int. 2022;37(6):daac149. https:\/\/doi.org\/10.1093\/heapro\/daac149.","DOI":"10.1093\/heapro\/daac149"},{"issue":"3","key":"26647_CR12","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1093\/her\/cyad002","volume":"38","author":"R Brown","year":"2023","unstructured":"Brown R, Van Godwin J, Edwards A, Burdon M, Moore G. A qualitative exploration of stakeholder perspectives on the implementation of a whole school approach to mental health and emotional well-being in Wales. Health Educ Res. 2023;38(3):241\u201353.","journal-title":"Health Educ Res"},{"issue":"3","key":"26647_CR13","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1080\/00131881.2019.1625716","volume":"61","author":"K Schildkamp","year":"2019","unstructured":"Schildkamp K. Data-based decision-making for school improvement: research insights and gaps. Educ Res. 2019;61(3):257\u201373.","journal-title":"Educ Res"},{"key":"26647_CR14","doi-asserted-by":"publisher","first-page":"482","DOI":"10.5334\/ijic.ICIC24229","volume":"25","author":"B Clarke","year":"2025","unstructured":"Clarke B, Anderson D, Rallapalli G, McCluney J, McWilliams P, Corrigan D, et al. Delivering a population health profile for pilot area integrated partnership board (AIPB) in Northern Ireland through development of a dashboard. Int J Integr Care. 2025;25:482.","journal-title":"Int J Integr Care"},{"issue":"1","key":"26647_CR15","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1177\/23998083241245759","volume":"52","author":"Y Nidam","year":"2025","unstructured":"Nidam Y, Gibson R, Houston-Read R, Picard M, Gavin V. Practicing data inclusion: Co-creation of an urban data dashboard. Environ Plan B Urban Anal City Sci. 2025;52(1):7\u201325.","journal-title":"Environ Plan B Urban Anal City Sci"},{"issue":"2","key":"26647_CR16","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1080\/10550887.2017.1291051","volume":"36","author":"AT Ramsey","year":"2017","unstructured":"Ramsey AT, Baumann A, Patterson DSW, Yan Y, Cooper B, Proctor E. The need for data-informed clinical supervision in substance use disorder treatment. J Addict Dis. 2017;36(2):117\u201326.","journal-title":"J Addict Dis"},{"issue":"1","key":"26647_CR17","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s41239-021-00313-7","volume":"19","author":"T Susnjak","year":"2022","unstructured":"Susnjak T, Ramaswami GS, Mathrani A. Learning analytics dashboard: a tool for providing actionable insights to learners. Int J Educ Technol High Educ. 2022;19(1):12.","journal-title":"Int J Educ Technol High Educ"},{"issue":"4","key":"26647_CR18","first-page":"61","volume":"21","author":"S Michaeli","year":"2020","unstructured":"Michaeli S, Kroparo D, Hershkovitz A. Teachers\u2019 use of education dashboards and professional growth. Int Rev Res Open Distrib Learn. 2020;21(4):61\u201378.","journal-title":"Int Rev Res Open Distrib Learn"},{"issue":"4","key":"26647_CR19","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/PHH.0000000000001746","volume":"29","author":"NW Anderson","year":"2023","unstructured":"Anderson NW, Russ SA, Eisenberg D, Halfon N. Dashboards as mechanisms for community empowerment: developing a prototype for child and adolescent Well-being in California. J Public Health Manag Pract. 2023;29(4):529\u201338.","journal-title":"J Public Health Manag Pract"},{"issue":"10","key":"26647_CR20","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1016\/j.socscimed.2010.01.034","volume":"70","author":"N Keshavarz","year":"2010","unstructured":"Keshavarz N, Nutbeam D, Rowling L, Khavarpour F. Schools as social complex adaptive systems: a new way to understand the challenges of introducing the health promoting schools concept. Soc Sci Med. 2010;70(10):1467\u201374.","journal-title":"Soc Sci Med"},{"issue":"1","key":"26647_CR21","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s11121-018-0969-3","volume":"22","author":"S Murphy","year":"2021","unstructured":"Murphy S, Littlecott H, Hewitt G, MacDonald S, Roberts J, Bishop J, et al. A transdisciplinary complex adaptive systems (T-CAS) approach to developing a National school-Based culture of prevention for health improvement: the school health research network (SHRN) in Wales. Prev Sci. 2021;22(1):50\u201361.","journal-title":"Prev Sci"},{"key":"26647_CR22","doi-asserted-by":"publisher","unstructured":"Page N, Liu S, Morgan K, Angel L, Ogada E, Roberts C et al. Data resource profile: the school health research network (SHRN) student health and Well-being (SHW) survey of 11\u201316-year-olds (2017\u20132023). Int J Epidemiol.\u00a02024;53(6). https:\/\/doi.org\/10.1093\/ije\/dyae161.","DOI":"10.1093\/ije\/dyae161"},{"key":"26647_CR23","unstructured":"Welsh Government. https:\/\/mylocalschool.gov.wales\/."},{"key":"26647_CR24","unstructured":"Public Health Wales. Welsh Network of Healthy School Schemes https:\/\/ https:\/\/phw.nhs.wales\/services-and-teams\/welsh-network-of-healthy-school-schemes\/ : Public Health Wales."},{"issue":"4","key":"26647_CR25","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1080\/2159676X.2019.1628806","volume":"11","author":"V Braun","year":"2019","unstructured":"Braun V, Clarke V. Reflecting on reflexive thematic analysis. QQual Res Sport Exerc Health. 2019;11(4):589\u201397.","journal-title":"QQual Res Sport Exerc Health"},{"issue":"2","key":"26647_CR26","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1191\/1478088706qp063oa","volume":"3","author":"V Braun","year":"2006","unstructured":"Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol. 2006;3(2):77\u2013101.","journal-title":"Qual Res Psychol"},{"issue":"3\u20134","key":"26647_CR27","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s10464-009-9229-9","volume":"43","author":"P Hawe","year":"2009","unstructured":"Hawe P, Shiell A, Riley T. Theorising interventions as events in systems. Am J Community Psychol. 2009;43(3\u20134):267\u201376.","journal-title":"Am J Community Psychol"},{"issue":"1","key":"26647_CR28","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1186\/s12889-023-15713-9","volume":"23","author":"E Widnall","year":"2023","unstructured":"Widnall E, Hatch L, Albers PN, Hopkins G, Kidger J, de Vocht F, et al. Implementing a regional school health research network in England to improve adolescent health and well-being, a qualitative process evaluation. BMC Public Health. 2023;23(1):745.","journal-title":"BMC Public Health"},{"key":"26647_CR29","unstructured":"Welsh Government. Curriculum for Wales Available from: https:\/\/hwb.gov.wales\/curriculum-for-wales. \/ [Accessed 20th June 2024]2020 [Available from: https:\/\/hwb.gov.wales\/curriculum-for-wales\/."},{"key":"26647_CR30","unstructured":"Welsh Government. Framework on embedding a whole-school approach to emotional and mental well-being. [Available from: https:\/\/www.gov.wales\/framework-embedding-whole-school-approach-emotional-and-mental-wellbeing. [Accessed 20th June 2024].2021 [Available from: https:\/\/www.gov.wales\/framework-embedding-whole-school-approach-emotional-and-mental-wellbeing."},{"issue":"1","key":"26647_CR31","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/rev3.3246","volume":"9","author":"GA Koh","year":"2021","unstructured":"Koh GA, Askell-Williams H. Sustainable school\u2010improvement in complex adaptive systems: a scoping review. Rev Educ. 2021;9(1):281\u2013314.","journal-title":"Rev Educ"},{"issue":"3","key":"26647_CR32","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1093\/pubmed\/fdt103","volume":"36","author":"S Dewhirst","year":"2013","unstructured":"Dewhirst S, Pickett K, Speller V, Shepherd J, Byrne J, Almond P, et al. Are trainee teachers being adequately prepared to promote the health and well-being of school children? A survey of current practice. J Public Health (Oxf). 2013;36(3):467\u201375.","journal-title":"J Public Health (Oxf)"},{"issue":"1","key":"26647_CR33","doi-asserted-by":"publisher","first-page":"1946928","DOI":"10.1080\/17482631.2021.1946928","volume":"16","author":"D Byrne","year":"2021","unstructured":"Byrne D, Carthy DA. A qualitative exploration of post-primary educators\u2019 attitudes regarding the promotion of student wellbeing. Int J Qual Stud Health Well-being. 2021;16(1):1946928.","journal-title":"Int J Qual Stud Health Well-being"},{"key":"26647_CR34","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.tate.2017.10.020","volume":"69","author":"J Byrne","year":"2018","unstructured":"Byrne J, Rietdijk W, Pickett K. Teachers as health promoters: factors that influence early career teachers to engage with health and wellbeing education. Teach Teach Educ. 2018;69:289\u201399.","journal-title":"Teach Teach Educ"},{"key":"26647_CR35","doi-asserted-by":"publisher","unstructured":"Sivkovych H, Slyvka L, Hamerska I. Pre-service teachers training for efficient health promoting school activities performance. Adv Educ. 7(16):88\u201397. https:\/\/doi.org\/10.20535\/2410-8286.216792.","DOI":"10.20535\/2410-8286.216792"},{"issue":"3","key":"26647_CR36","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1177\/2373379916644449","volume":"2","author":"J Byrne","year":"2016","unstructured":"Byrne J, Pickett K, Rietdijk W, Shepherd J, Grace M, Roderick P. A longitudinal study to explore the impact of preservice teacher health training on early career teachers\u2019 roles as health promoters. Pedagogy Health Promot. 2016;2(3):170\u201383.","journal-title":"Pedagogy Health Promot"},{"issue":"1","key":"26647_CR37","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1177\/1356389018803219","volume":"25","author":"GF Moore","year":"2019","unstructured":"Moore GF, Evans RE, Hawkins J, Littlecott H, Melendez-Torres GJ, Bonell C, et al. From complex social interventions to interventions in complex social systems: future directions and unresolved questions for intervention development and evaluation. Evaluation (Lond). 2019;25(1):23\u201345.","journal-title":"Evaluation (Lond)"},{"issue":"4","key":"26647_CR38","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1108\/HE-07-2013-0031","volume":"114","author":"R Preiser","year":"2014","unstructured":"Preiser R, Struthers P, Mohamed S, Cameron N, Lawrence E. External stakeholders and health promoting schools: complexity and practice in South Africa. Health Educ. 2014;114(4):260\u201370.","journal-title":"Health Educ"},{"key":"26647_CR39","unstructured":"Page N, Angel L, Ogada E, Young H, Murphy S. Student health and wellbeing in wales: report of the 2021\/22 health behaviour in school-aged children survey and school health research network student health and wellbeing survey. Cardiff, UK: Cardiff University; 2023."}],"container-title":["BMC Public Health"],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12889-026-26647-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12889-026-26647-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12889-026-26647-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:47:13Z","timestamp":1774518433000},"score":10.11461,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12889-026-26647-3"}},"issued":{"date-parts":[[2026,2,18]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["26647"],"URL":"https:\/\/doi.org\/10.1186\/s12889-026-26647-3","ISSN":["1471-2458"],"issn-type":[{"value":"1471-2458","type":"electronic"}],"published":{"date-parts":[[2026,2,18]]},"assertion":[{"value":"31 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All participants provided written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Jeremy Segrott, Hayley Reed, and Nicholas Page led the early design and development of the SHRN data dashboard, with Martina Svobodova and Maria Boffey also contributing at this stage. Fran Rice, Yulia Shenderovich, Rhys Bevan Jones, and Simon Murphy served on the steering group, providing support and guidance throughout development. Nicholas Page and Maria Boffey are funded by SHRN, and Simon Murphy was its director during the research. The pilot study itself was conducted by Jordan Van Godwin, Brianna Bowen, and Sara Long, who were not involved in the dashboard\u2019s design or employed by SHRN.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"987"},{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T03:08:39Z","timestamp":1779073719293,"version":"3.51.4"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["106185\/Z\/14\/Z"],"award-info":[{"award-number":["106185\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["103986\/Z\/14\/Z"],"award-info":[{"award-number":["103986\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["215189\/Z\/19\/Z"],"award-info":[{"award-number":["215189\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["220001\/Z\/19\/Z"],"award-info":[{"award-number":["220001\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["204057\/Z\/16\/Z"],"award-info":[{"award-number":["204057\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["220001\/Z\/19\/Z"],"award-info":[{"award-number":["220001\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Syst Biol"],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"Abstract<\/jats:title>\n \n Ultradian oscillations of HES Transcription Factors (TFs) at the single\u2010cell level enable cell state transitions. However, the tissue\u2010level organisation of HES5 dynamics in neurogenesis is unknown. Here, we analyse the expression of HES5\n ex vivo<\/jats:italic>\n in the developing mouse ventral spinal cord and identify microclusters of 4\u20136 cells with positively correlated HES5 level and ultradian dynamics. These microclusters are spatially periodic along the dorsoventral axis and temporally dynamic, alternating between high and low expression with a supra\u2010ultradian persistence time. We show that Notch signalling is required for temporal dynamics but not the spatial periodicity of HES5. Few Neurogenin 2 cells are observed per cluster, irrespective of high or low state, suggesting that the microcluster organisation of HES5 enables the stable selection of differentiating cells. Computational modelling predicts that different cell coupling strengths underlie the HES5 spatial patterns and rate of differentiation, which is consistent with comparison between the motoneuron and interneuron progenitor domains. Our work shows a previously unrecognised spatiotemporal organisation of neurogenesis, emergent at the tissue level from the synthesis of single\u2010cell dynamics.\n <\/jats:p>","DOI":"10.15252\/msb.20209902","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T03:12:59Z","timestamp":1621912379000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["A dynamic, spatially periodic, micro\u2010pattern of HES5 underlies neurogenesis in the mouse spinal cord"],"prefix":"10.1038","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9592-385X","authenticated-orcid":false,"given":"Veronica","family":"Biga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2122-7530","authenticated-orcid":false,"given":"Joshua","family":"Hawley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-1837","authenticated-orcid":false,"given":"Ximena","family":"Soto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6383-055X","authenticated-orcid":false,"given":"Emma","family":"Johns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9088-1651","authenticated-orcid":false,"given":"Daniel","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayley","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5408-0013","authenticated-orcid":false,"given":"Antony D","family":"Adamson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0314-9623","authenticated-orcid":false,"given":"Jochen","family":"Kursawe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Glendinning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8656-5878","authenticated-orcid":false,"given":"Cerys S","family":"Manning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6992-6870","authenticated-orcid":false,"given":"Nancy","family":"Papalopulu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"BFMSB20209902_CR1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2004162","volume":"16","author":"C Baek","year":"2018","unstructured":"Baek C, Freem L, Goiame R, Sang H, Morin X, Tozer S (2018) Mib1 prevents Notch Cis\u2010inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination. PLoS Biol 16: e2004162","journal-title":"PLoS Biol"},{"key":"BFMSB20209902_CR2","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1242\/dev.147256","volume":"144","author":"S Bansod","year":"2017","unstructured":"Bansod S, Kageyama R, Ohtsuka T (2017) Hes5 regulates the transition timing of neurogenesis and gliogenesis in mammalian neocortical development. Development 144: 3156\u20133167","journal-title":"Development"},{"key":"BFMSB20209902_CR3","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2019.0436","volume":"16","author":"JW Baron","year":"2019","unstructured":"Baron JW, Galla T (2019) Intrinsic noise, Delta\u2010Notch signalling and delayed reactions promote sustained, coherent, synchronized oscillations in the presomitic mesoderm. J R Soc Interface 16: 20190436","journal-title":"J R Soc Interface"},{"key":"BFMSB20209902_CR4","volume-title":"Harmonic analysis and applications","author":"JJ Benedetto","year":"1996","unstructured":"Benedetto JJ (1996) Harmonic analysis and applications. Boca Raton, FL: CRC Press"},{"key":"BFMSB20209902_CR5","first-page":"E402","volume":"112","author":"M Boareto","year":"2015","unstructured":"Boareto M, Jolly MK, Lu M, Onuchic JN, Clementi C, Ben\u2010Jacob E (2015) Jagged\u2010delta asymmetry in Notch signaling can give rise to a sender\/receiver hybrid phenotype. Proc Natl Acad Sci USA 112: E402\u2013E409","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFMSB20209902_CR6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.celrep.2012.05.017","volume":"2","author":"B Bonev","year":"2012","unstructured":"Bonev B, Stanley P, Papalopulu N (2012) MicroRNA\u20109 Modulates Hes1 ultradian oscillations by forming a double\u2010negative feedback loop. Cell Rep 2: 10\u201318","journal-title":"Cell Rep"},{"key":"BFMSB20209902_CR7","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1242\/dev.129452","volume":"142","author":"J Briscoe","year":"2015","unstructured":"Briscoe J, Small S (2015) Morphogen rules: design principles of gradient\u2010mediated embryo patterning. Development 142: 3996\u20134009","journal-title":"Development"},{"key":"BFMSB20209902_CR8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1103\/PhysRevE.61.371","volume":"61","author":"MY Choi","year":"2000","unstructured":"Choi MY, Kim HJ, Kim D, Hong H (2000) Synchronization in a system of globally coupled oscillators with time delay. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 61: 371\u2013381","journal-title":"Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics"},{"key":"BFMSB20209902_CR9","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.devcel.2010.06.006","volume":"19","author":"M Cohen","year":"2010","unstructured":"Cohen M, Georgiou M, Stevenson NL, Miodownik M, Baum B (2010) Dynamic filopodia transmit intermittent Delta\u2010Notch signaling to drive pattern refinement during lateral inhibition. Dev Cell 19: 78\u201389","journal-title":"Dev Cell"},{"key":"BFMSB20209902_CR10","doi-asserted-by":"crossref","DOI":"10.1126\/science.aai7407","volume":"356","author":"F Corson","year":"2017","unstructured":"Corson F, Couturier L, Rouault H, Mazouni K, Schweisguth F (2017) Self\u2010organized Notch dynamics generate stereotyped sensory organ patterns in Drosophila. Science 356: eaai7407","journal-title":"Science"},{"key":"BFMSB20209902_CR11","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/embor.2012.42","volume":"13","author":"RM Das","year":"2012","unstructured":"Das RM, Storey KG (2012) Mitotic spindle orientation can direct cell fate and bias Notch activity in chick neural tube. EMBO Rep 13: 448\u2013454","journal-title":"EMBO Rep"},{"key":"BFMSB20209902_CR12","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1126\/science.1247521","volume":"343","author":"RM Das","year":"2014","unstructured":"Das RM, Storey KG (2014) Apical abscission alters cell polarity and dismantles the primary cilium during neurogenesis. Science 343: 200\u2013204","journal-title":"Science"},{"key":"BFMSB20209902_CR13","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nature02157","volume":"426","author":"C De Joussineau","year":"2003","unstructured":"De Joussineau C, Soul\u00e9 J, Martin M, Anguille C, Montcourrier P, Alexandre D (2003) Delta\u2010promoted filopodia mediate long\u2010range lateral inhibition in Drosophila. Nature 426: 555\u2013559","journal-title":"Nature"},{"key":"BFMSB20209902_CR14","doi-asserted-by":"crossref","DOI":"10.1242\/dev.173807","volume":"146","author":"J Delile","year":"2019","unstructured":"Delile J, Rayon T, Melchionda M, Edwards A, Briscoe J, Sagner A (2019) Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord. Development 146: dev.173807","journal-title":"Development"},{"key":"BFMSB20209902_CR15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/bioinformatics\/btg454","volume":"20","author":"PH Eilers","year":"2004","unstructured":"Eilers PH, Goeman JJ (2004) Enhancing scatterplots with smoothed densities. Bioinformatics 20: 623\u2013628","journal-title":"Bioinformatics"},{"key":"BFMSB20209902_CR16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/dgd.12644","volume":"62","author":"J Falo\u2010Sanjuan","year":"2020","unstructured":"Falo\u2010Sanjuan J, Bray SJ (2020) Decoding the Notch signal. Dev Growth Differ 62: 4\u201314","journal-title":"Dev Growth Differ"},{"key":"BFMSB20209902_CR17","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.80.021909","volume":"80","author":"T Galla","year":"2009","unstructured":"Galla T (2009) Intrinsic fluctuations in stochastic delay systems: theoretical description and application to a simple model of gene regulation. Phys Rev E 80: 021909","journal-title":"Phys Rev E"},{"key":"BFMSB20209902_CR18","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1038\/ncomms4399","volume":"5","author":"M Goodfellow","year":"2014","unstructured":"Goodfellow M, Phillips NE, Manning C, Galla T, Papalopulu N (2014) microRNA input into a neural ultradian oscillator controls emergence and timing of alternative cell states. Nat Commun 5: 3399","journal-title":"Nat Commun"},{"key":"BFMSB20209902_CR19","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.devcel.2019.05.035","volume":"49","author":"Z Hadjivasiliou","year":"2019","unstructured":"Hadjivasiliou Z, Moore RE, McIntosh R, Galea GL, Clarke JDW, Alexandre P (2019) Basal protrusions mediate spatiotemporal patterns of spinal neuron differentiation. Dev Cell 49: 907\u2013919","journal-title":"Dev Cell"},{"key":"BFMSB20209902_CR20","doi-asserted-by":"crossref","DOI":"10.1242\/dev.172148","volume":"146","author":"D Henrique","year":"2019","unstructured":"Henrique D, Schweisguth F (2019) Mechanisms of Notch signaling: a simple logic deployed in time and space. Development 146: dev172148","journal-title":"Development"},{"key":"BFMSB20209902_CR21","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.cub.2010.06.034","volume":"20","author":"L Herrgen","year":"2010","unstructured":"Herrgen L, Ares S, Morelli LG, Schr\u00f6ter C, J\u00fclicher F, Oates AC (2010) Intercellular coupling regulates the period of the segmentation clock. Curr Biol 20: 1244\u20131253","journal-title":"Curr Biol"},{"key":"BFMSB20209902_CR22","first-page":"2305","volume":"143","author":"GL Hunter","year":"2016","unstructured":"Hunter GL, Hadjivasiliou Z, Bonin H, He L, Perrimon N, Charras G, Baum B (2016) Coordinated control of Notch\/Delta signalling and cell cycle progression drives lateral inhibition\u2010mediated tissue patterning. Development 143: 2305\u20132310","journal-title":"Development"},{"key":"BFMSB20209902_CR23","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1126\/science.1242366","volume":"342","author":"I Imayoshi","year":"2013","unstructured":"Imayoshi I, Isomura A, Harima Y, Kawaguchi K, Kori H, Miyachi H, Fujiwara T, Ishidate F, Kageyama R (2013) Oscillatory control of factors determining multipotency and fate in mouse neural progenitors. Science 342: 1203\u20131208","journal-title":"Science"},{"key":"BFMSB20209902_CR24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuron.2014.03.018","volume":"82","author":"I Imayoshi","year":"2014","unstructured":"Imayoshi I, Kageyama R (2014) bHLH factors in self\u2010renewal, multipotency, and fate choice of neural progenitor cells. Neuron 82: 9\u201323","journal-title":"Neuron"},{"key":"BFMSB20209902_CR25","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1101\/gad.294546.116","volume":"31","author":"A Isomura","year":"2017","unstructured":"Isomura A, Ogushi F, Kori H, Kageyama R (2017) Optogenetic perturbation and bioluminescence imaging to analyze cell\u2010to\u2010cell transfer of oscillatory information. Genes Dev 31: 524\u2013535","journal-title":"Genes Dev"},{"key":"BFMSB20209902_CR26","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0014-5793(03)00279-5","volume":"541","author":"MH Jensen","year":"2003","unstructured":"Jensen MH, Sneppen K, Tiana G (2003) Sustained oscillations and time delays in gene expression of protein Hes1. FEBS Lett 541: 176\u2013177","journal-title":"FEBS Lett"},{"key":"BFMSB20209902_CR27","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/nn.2208","volume":"11","author":"R Kageyama","year":"2008","unstructured":"Kageyama R, Ohtsuka T, Shimojo H, Imayoshi I (2008) Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition. Nat Neurosci 11: 1247\u20131251","journal-title":"Nat Neurosci"},{"key":"BFMSB20209902_CR28","doi-asserted-by":"crossref","DOI":"10.1126\/science.1254927","volume":"345","author":"A Kicheva","year":"2014","unstructured":"Kicheva A, Bollenbach T, Ribeiro A, Valle HP, Lovell\u2010Badge R, Episkopou V, Briscoe J (2014) Coordination of progenitor specification and growth in mouse and chick spinal cord. Science 345: 1254927","journal-title":"Science"},{"key":"BFMSB20209902_CR29","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1101\/gad.1823109","volume":"23","author":"T Kobayashi","year":"2009","unstructured":"Kobayashi T, Mizuno H, Imayoshi I, Furusawa C, Shirahige K, Kageyama R (2009) The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Genes Dev 23: 1870\u20131875","journal-title":"Genes Dev"},{"key":"BFMSB20209902_CR30","volume":"10","author":"K Kuzmicz\u2010Kowalska","year":"2020","unstructured":"Kuzmicz\u2010Kowalska K, Kicheva A (2020) Regulation of size and scale in vertebrate spinal cord development. Wiley Interdiscip Rev Dev Biol 10: e383","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"BFMSB20209902_CR31","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/S0960-9822(03)00534-7","volume":"13","author":"J Lewis","year":"2003","unstructured":"Lewis J (2003) Autoinhibition with transcriptional delay. Curr Biol 13: 1398\u20131408","journal-title":"Curr Biol"},{"key":"BFMSB20209902_CR32","doi-asserted-by":"publisher","DOI":"10.1101\/335869","author":"KH de Lichtenberg","year":"2018","unstructured":"de Lichtenberg KH, Funa N, Nakic N, Ferrer J, Zhu Z, Huangfu D, Serup P (2018) Genome\u2010wide identification of HES1 target genes uncover novel roles for HES1 in pancreatic development. bioRxiv https:\/\/doi.org\/10.1101\/335869 [PREPRINT]","journal-title":"bioRxiv"},{"key":"BFMSB20209902_CR33","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.neuron.2018.09.031","volume":"100","author":"V Lopes\u2010Dos\u2010Santos","year":"2018","unstructured":"Lopes\u2010Dos\u2010Santos V, van de Ven GM, Morley A, Trouche S, Campo\u2010Urriza N, Dupret D (2018) Parsing hippocampal theta oscillations by nested spectral components during spatial exploration and memory\u2010guided behavior. Neuron 100: 940\u2013952","journal-title":"Neuron"},{"key":"BFMSB20209902_CR34","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/nprot.2013.109","volume":"8","author":"A Lyubimova","year":"2013","unstructured":"Lyubimova A, Itzkovitz S, Junker JP, Fan ZP, Wu X, van Oudenaarden A (2013) Single\u2010molecule mRNA detection and counting in mammalian tissue. Nat Protoc 8: 1743\u20131758","journal-title":"Nat Protoc"},{"key":"BFMSB20209902_CR35","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0896-6273(00)80988-5","volume":"20","author":"Q Ma","year":"1998","unstructured":"Ma Q, Chen Z, del Barco BI, de la Pompa JL, Anderson DJ (1998) neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 20: 469\u2013482","journal-title":"Neuron"},{"key":"BFMSB20209902_CR36","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1038\/s41467-019-10734-8","volume":"10","author":"CS Manning","year":"2019","unstructured":"Manning CS, Biga V, Boyd J, Kursawe J, Ymisson B, Spiller DG, Sanderson CM, Galla T, Rattray M, Papalopulu N (2019) Quantitative single\u2010cell live imaging links HES5 dynamics with cell\u2010state and fate in murine neurogenesis. Nat Commun 10: 2835","journal-title":"Nat Commun"},{"key":"BFMSB20209902_CR37","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1242\/dev.036806","volume":"137","author":"U Marklund","year":"2010","unstructured":"Marklund U, Hansson EM, Sundstr\u00f6m E, de Angelis MH, Przemeck GK, Lendahl U, Muhr J, Ericson J (2010) Domain\u2010specific control of neurogenesis achieved through patterned regulation of Notch ligand expression. Development 137: 437\u2013445","journal-title":"Development"},{"key":"BFMSB20209902_CR38","doi-asserted-by":"crossref","first-page":"8409","DOI":"10.1073\/pnas.1813492116","volume":"116","author":"AN Marra","year":"2019","unstructured":"Marra AN, Adeeb BD, Chambers BE, Drummond BE, Ulrich M, Addiego A, Springer M, Poureetezadi SJ, Chambers JM, Ronshaugen M et al (2019) Prostaglandin signaling regulates renal multiciliated cell specification and maturation. Proc Natl Acad Sci USA 116: 8409\u20138418","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFMSB20209902_CR39","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.jtbi.2008.07.013","volume":"254","author":"H Momiji","year":"2008","unstructured":"Momiji H, Monk NAM (2008) Dissecting the dynamics of the Hes1 genetic oscillator. J Theor Biol 254: 784\u2013798","journal-title":"J Theor Biol"},{"key":"BFMSB20209902_CR40","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/S0960-9822(03)00494-9","volume":"13","author":"NAM Monk","year":"2003","unstructured":"Monk NAM (2003) Oscillatory expression of Hes1, p53, and NF\u2010\u03baB driven by transcriptional time delays. Curr Biol 13: 1409\u20131413","journal-title":"Curr Biol"},{"key":"BFMSB20209902_CR41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2976\/1.3027088","volume":"3","author":"LG Morelli","year":"2009","unstructured":"Morelli LG, Ares S, Herrgen L, Schr\u00f6ter C, J\u00fclicher F, Oates AC (2009) Delayed coupling theory of vertebrate segmentation. HFSP J 3: 55\u201366","journal-title":"HFSP J"},{"key":"BFMSB20209902_CR42","volume":"9","author":"BR Nelson","year":"2020","unstructured":"Nelson BR, Hodge RD, Daza RA, Tripathi PP, Arnold SJ, Millen KJ, Hevner RF (2020) Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches. eLife 9: e53777","journal-title":"eLife"},{"key":"BFMSB20209902_CR43","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.gde.2020.04.008","volume":"63","author":"AC Oates","year":"2020","unstructured":"Oates AC (2020) Waiting on the Fringe: cell autonomy and signaling delays in segmentation clocks. Curr Opin Genet Dev 63: 61\u201370","journal-title":"Curr Opin Genet Dev"},{"key":"BFMSB20209902_CR44","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1093\/emboj\/18.8.2196","volume":"18","author":"T Ohtsuka","year":"1999","unstructured":"Ohtsuka T, Ishibashi M, Gradwohl G, Nakanishi S, Guillemot F, Kageyama R (1999) Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J 18: 2196\u20132207","journal-title":"EMBO J"},{"key":"BFMSB20209902_CR45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.0040015","volume":"4","author":"EM \u00d6zbudak","year":"2008","unstructured":"\u00d6zbudak EM, Lewis J (2008) Notch signalling synchronizes the zebrafish segmentation clock but is not needed to create somite boundaries. PLoS Genet 4: e15","journal-title":"PLoS Genet"},{"key":"BFMSB20209902_CR46","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/embr.201438447","volume":"15","author":"JT Paridaen","year":"2014","unstructured":"Paridaen JT, Huttner WB (2014) Neurogenesis during development of the vertebrate central nervous system. EMBO Rep 15: 351\u2013364","journal-title":"EMBO Rep"},{"key":"BFMSB20209902_CR47","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1242\/dev.108100","volume":"141","author":"J Petrovic","year":"2014","unstructured":"Petrovic J, Formosa\u2010Jordan P, Luna\u2010Escalante JC, Abello G, Iban M, Es NJ, Giraldez F, Abell\u00f3 G, Iba\u00f1es M et al (2014) Ligand\u2010dependent Notch signaling strength orchestrates lateral induction and lateral inhibition in the developing inner ear. Development 141: 2313\u20132324","journal-title":"Development"},{"key":"BFMSB20209902_CR48","volume":"5","author":"NE Phillips","year":"2016","unstructured":"Phillips NE, Manning CS, Pettini T, Biga V, Marinopoulou E, Stanley P, Boyd J, Bagnall J, Paszek P, Spiller DG et al (2016) Stochasticity in the miR\u20109\/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation. eLife 5: e16118","journal-title":"eLife"},{"key":"BFMSB20209902_CR49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015515","volume":"5","author":"C Ramos","year":"2010","unstructured":"Ramos C, Rocha S, Gaspar C, Henrique D (2010) Two Notch ligands, Dll1 and Jag1, are differently restricted in their range of action to control neurogenesis in the mammalian spinal cord. PLoS One 5: e15515","journal-title":"PLoS One"},{"key":"BFMSB20209902_CR50","doi-asserted-by":"crossref","DOI":"10.1242\/dev.182154","volume":"146","author":"A Sagner","year":"2019","unstructured":"Sagner A, Briscoe J (2019) Establishing neuronal diversity in the spinal cord: a time and a place. Development 146: dev182154","journal-title":"Development"},{"key":"BFMSB20209902_CR51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2003127","volume":"16","author":"A Sagner","year":"2018","unstructured":"Sagner A, Gaber ZB, Delile J, Kong JH, Rousso DL, Pearson CA, Weicksel SE, Melchionda M, Mousavy Gharavy SN, Briscoe J et al (2018) Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics. PLoS Biol 16: e2003127","journal-title":"PLoS Biol"},{"key":"BFMSB20209902_CR52","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.gde.2011.07.007","volume":"21","author":"O Shaya","year":"2011","unstructured":"Shaya O, Sprinzak D (2011) From Notch signaling to fine\u2010grained patterning: modeling meets experiments. Curr Opin Genet Dev 21: 732\u2013739","journal-title":"Curr Opin Genet Dev"},{"key":"BFMSB20209902_CR53","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1101\/gad.270785.115","volume":"30","author":"H Shimojo","year":"2016","unstructured":"Shimojo H, Isomura A, Ohtsuka T, Kori H, Miyachi H, Kageyama R (2016) Oscillatory control of Delta\u2010like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis. Genes Dev 30: 102\u2013116","journal-title":"Genes Dev"},{"key":"BFMSB20209902_CR54","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.semcdb.2016.01.017","volume":"49","author":"H Shimojo","year":"2016","unstructured":"Shimojo H, Kageyama R (2016) Oscillatory control of Delta\u2010like1 in somitogenesis and neurogenesis: a unified model for different oscillatory dynamics. Semin Cell Dev Biol 49: 76\u201382","journal-title":"Semin Cell Dev Biol"},{"key":"BFMSB20209902_CR55","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.cell.2018.01.026","volume":"172","author":"KF Sonnen","year":"2018","unstructured":"Sonnen KF, Lauschke VM, Uraji J, Falk HJ, Petersen Y, Funk MC, Beaupeux M, Fran\u00e7ois P, Merten CA, Aulehla A (2018) Modulation of phase shift between Wnt and Notch signaling oscillations controls mesoderm segmentation. Cell 172: 1079\u20131090","journal-title":"Cell"},{"key":"BFMSB20209902_CR56","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019103558","volume":"39","author":"X Soto","year":"2020","unstructured":"Soto X, Biga V, Kursawe J, Lea R, Doostdar P, Thomas R, Papalopulu N (2020) Dynamic properties of noise and Her6 levels are optimized by miR\u20109, allowing the decoding of the Her6 oscillator. EMBO J 39: e103558","journal-title":"EMBO J"},{"key":"BFMSB20209902_CR57","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nature08959","volume":"465","author":"D Sprinzak","year":"2010","unstructured":"Sprinzak D, Lakhanpal A, Lebon L, Santat LA, Fontes ME, Anderson GA, Garcia\u2010Ojalvo J, Elowitz MB (2010) Cis\u2010interactions between Notch and Delta generate mutually exclusive signalling states. Nature 465: 86\u201390","journal-title":"Nature"},{"key":"BFMSB20209902_CR58","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jtbi.2017.06.006","volume":"430","author":"HB Tiedemann","year":"2017","unstructured":"Tiedemann HB, Schneltzer E, Beckers J, Przemeck GKH, Hrab\u011b de Angelis M (2017) Modeling coexistence of oscillation and Delta\/Notch\u2010mediated lateral inhibition in pancreas development and neurogenesis. J Theor Biol 430: 32\u201344","journal-title":"J Theor Biol"},{"key":"BFMSB20209902_CR59","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.cell.2016.01.028","volume":"164","author":"CD Tsiairis","year":"2016","unstructured":"Tsiairis CD, Aulehla A (2016) Self\u2010organization of embryonic genetic oscillators into spatiotemporal wave patterns. Cell 164: 656\u2013667","journal-title":"Cell"},{"key":"BFMSB20209902_CR60","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1741-7007-9-58","volume":"9","author":"F Vilas\u2010Boas","year":"2011","unstructured":"Vilas\u2010Boas F, Fior R, Swedlow JR, Storey KG, Henrique D (2011) A novel reporter of notch signalling indicates regulated and random Notch activation during vertebrate neurogenesis. BMC Biol 9: 58","journal-title":"BMC Biol"},{"key":"BFMSB20209902_CR61","volume":"5","author":"AB Webb","year":"2016","unstructured":"Webb AB, Lengyel IM, J\u00f6rg DJ, Valentin G, J\u00fclicher F, Morelli LG, Oates AC (2016) Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock. eLife 5: e08438","journal-title":"eLife"},{"key":"BFMSB20209902_CR62","first-page":"E9469","volume":"115","author":"YE Wu","year":"2018","unstructured":"Wu YE, Enoki R, Oda Y, Huang ZL, Honma KI, Honma S (2018) Ultradian calcium rhythms in the paraventricular nucleus and subparaventricular zone in the hypothalamus. Proc Natl Acad Sci USA 115: E9469\u2013E9478","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Molecular Systems Biology"],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/msb.20209902.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/msb.20209902","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/msb.20209902\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/msb.20209902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/msb.20209902.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T02:58:38Z","timestamp":1779073118000},"score":10.007283,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/msb.20209902"}},"issued":{"date-parts":[[2021,5,1]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5,1]]}},"alternative-id":["BFMSB20209902"],"URL":"https:\/\/doi.org\/10.15252\/msb.20209902","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.08.03.234369","asserted-by":"object"}]},"ISSN":["1744-4292"],"issn-type":[{"value":"1744-4292","type":"electronic"}],"published":{"date-parts":[[2021,5,1]]},"assertion":[{"value":"3 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"MSB20209902"},{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T19:02:35Z","timestamp":1779822155522,"version":"3.53.1"},"reference-count":87,"publisher":"National Academy of Sciences","issue":"22","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["100229\/Z\/12\/Z"],"award-info":[{"award-number":["100229\/Z\/12\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["220291\/Z\/20\/Z"],"award-info":[{"award-number":["220291\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["203147\/Z\/16\/Z"],"award-info":[{"award-number":["203147\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["205103\/Z\/16\/Z"],"award-info":[{"award-number":["205103\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["224562\/Z\/21\/Z"],"award-info":[{"award-number":["224562\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"Reading is central to academic and vocational success. Some deaf children face reading challenges due to limited access to spoken or signed language. Robust phonological representations are key to reading development in hearing children. Spoken language phonology may be one of many contributors to reading development in deaf children. Indeed, speechreading ability correlates with reading skill in both deaf and hearing individuals, suggesting it is linked to reading development regardless of hearing status. Further support for this hypothesis would be provided by evidence that similar neural representations of speech phonology are evoked by visual speech and other language forms (auditory speech and text) and that these neural representations are related to reading proficiency. We used fMRI and representational similarity analysis (RSA) to identify shared neural representations of spoken language phonological structure. A group of deaf adult participants (N = 22), with a mixture of sign language and spoken language backgrounds and reading abilities, were presented with single lexical items as visual speech and dynamic text (cursive text, revealed letter-by-letter to promote a phonological reading strategy). Adult hearing participants (N = 25) were presented with the same words, but as visual speech and auditory speech. Shared neural representations of phonological structure of English words were found in each group in the superior and middle temporal cortex (STC\/MTC) and these abstract representations were more similar across different language forms in better readers. Our data provide neurobiological evidence of the contribution of visual speech to abstract phonological representations of spoken language, that relate to reading proficiency, in both deaf and hearing adults.<\/jats:p>","DOI":"10.1073\/pnas.2535704123","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T18:11:09Z","timestamp":1779819069000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Reading ability in both deaf and hearing adults is linked to neural representations of abstract phonology derived from visual speech"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9667-0671","authenticated-orcid":false,"given":"Samuel","family":"Evans","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Cognitive Neuroscience, University College London","place":["London, United Kingdom"]},{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"Deafness Cognition and Language Research Centre, Division of Psychology and Language Sciences, University College London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy J.","family":"Price","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Imaging Neuroscience, Queen Square Institute of Neurology, University College London","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0264-8532","authenticated-orcid":false,"given":"J\u00f6rn","family":"Diedrichsen","sequence":"additional","affiliation":[{"name":"Western Institute for Neuroscience, Western University","place":["London, Canada"]},{"name":"Department of Computer Science, Western University","place":["London, Canada"]},{"name":"Department of Statistical and Actuarial Sciences, Western University","place":["London, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9749-5895","authenticated-orcid":false,"given":"Tae","family":"Twomey","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Cognitive Neuroscience, University College London","place":["London, United Kingdom"]},{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"Deafness Cognition and Language Research Centre, Division of Psychology and Language Sciences, University College London","place":["London, United Kingdom"]},{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Imaging Neuroscience, Queen Square Institute of Neurology, University College London","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indie","family":"Beedie","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Cognitive Neuroscience, University College London","place":["London, United Kingdom"]},{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"Deafness Cognition and Language Research Centre, Division of Psychology and Language Sciences, University College London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie","family":"Fraser","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Cognitive Neuroscience, University College London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-3507","authenticated-orcid":false,"given":"Mair\u00e9ad","family":"MacSweeney","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Cognitive Neuroscience, University College London","place":["London, United Kingdom"]},{"id":[{"id":"https:\/\/ror.org\/02jx3x895","id-type":"ROR","asserted-by":"publisher"}],"name":"Deafness Cognition and Language Research Centre, Division of Psychology and Language Sciences, University College London","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1353\/aad.2012.1611"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10882-011-9246-0"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/deafed\/enr028"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11145-004-5894-0"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0963-7214.2005.00376.x"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1529100618772271"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2006.01700.x"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/deafed\/eng012"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.deafed.a014351"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/deafed\/enj037"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1353\/aad.2014.0032"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.01153"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/deafed\/enq049"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/deafed\/enac018"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1044\/2020_JSLHR-20-00159"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/deafed\/enj021"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jecp.2010.04.011"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1044\/2024_LSHSS-23-00129"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/02699200500266745"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1992.0009"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1044\/2019_JSLHR-H-19-0073"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2015.07.013"},{"key":"e_1_3_4_23_2","first-page":"1","article-title":"Hierarchical organization of auditory and motor representations in speech perception: Evidence from searchlight similarity analysis","author":"Evans S.","year":"2015","unstructured":"S. Evans, M. H. Davis, Hierarchical organization of auditory and motor representations in speech perception: Evidence from searchlight similarity analysis, Cerebral cortex (New York, N.Y.: 1991), (2015), pp. 1\u201317, 10.1093\/cercor\/bhv136.","journal-title":"Cerebral cortex (New York, N.Y.: 1991)"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164318"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.07.023"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.01.060"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0114-21.2021"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00343-4"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-934X(03)00403-6"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0030266"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","unstructured":"M. S. Beauchamp K. E. Lee B. D. Argall A. Martin Integration of auditory and visual information about objects in superior temporal sulcus. Neuron 41 809\u2013823 (2004).","DOI":"10.1016\/S0896-6273(04)00070-4"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26713"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4572-10.2011"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2009.10.004"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00151"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.08.075"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","unstructured":"I. Simanova P. Hagoort R. Oostenveld M. A. J. van Gerven \u201cModality-independent decoding of semantic information from the human brain\u201d in Cerebral Cortex (New York N.Y.: 1991) (2014) vol. 24 pp. 426\u2013434.","DOI":"10.1093\/cercor\/bhs324"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56972"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1415-24.2025"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00161"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1057\/9780230625396_6"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/264746a0"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20032"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.061"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2023.105304"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10548-023-00959-8"},{"key":"e_1_3_4_47_2","unstructured":"J. Alegria J. Leybaert C. Hage \u201cThe origin of phonological representations in the deaf\u201d in Language Processing in Spanish M. Carreiras J. E. Garcia-Albea N. Sebastian-Galles Eds. (1992) pp. 107\u2013132."},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1044\/2025_JSLHR-24-00872"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/desc.13124"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/desc.13431"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1044\/2015_JSLHR-S-14-0269"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-7610.00648"},{"key":"e_1_3_4_53_2","doi-asserted-by":"crossref","unstructured":"V. L. Hanson C. A. Fowler Phonological coding in word reading: Evidence from hearing and deaf readers. Mem. Cogn. 15 199\u2013207 (1987).","DOI":"10.3758\/BF03197717"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0327142"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0963-7214.2005.00372.x"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/wcs.1404"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2013.05.001"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2016.06.007"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2018.07.010"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1162\/NOL.a.13"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/lnc3.12407"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.12.046"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.12.047"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.04.003"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2007.11.026"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054696"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.01.025"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/jdsade\/enag004"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.716554"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/deafed\/enw065"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.deafed.a014308"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1353\/sls.2015.0006"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139610"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.3390\/languages8010059"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2015.10.004"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2113"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2331"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.04.062"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.03.019"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00206"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1162\/imag_a_00524"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.04.001"},{"key":"e_1_3_4_83_2","first-page":"11","article-title":"Reading comprehension test","volume":"7","author":"Warden V.","year":"1996","unstructured":"V. Warden, Reading comprehension test. Dyslexia Review 7, 11\u201316 (1996).","journal-title":"Dyslexia Review"},{"key":"e_1_3_4_84_2","unstructured":"T. Ellis M. MacSweeney B. Dodd R. Campbell \u201cTAS: A new test of adult speechreading. Deaf people really can be better speechreaders\u201d in International Conference on Auditory-Visual Speech Processing (2001) pp. 1\u20135."},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003553"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.12.012"},{"key":"e_1_3_4_87_2","doi-asserted-by":"crossref","unstructured":"S. Evans Reading ability in both deaf and hearing adults is linked to neural representations of abstract phonology derived from visual speech. OSF. https:\/\/osf.io\/cba8z\/overview. Deposited 1 May 2026.","DOI":"10.1101\/2025.11.09.684749"}],"container-title":["Proceedings of the National Academy of Sciences"],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2535704123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T18:13:09Z","timestamp":1779819189000},"score":9.905265,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2535704123"}},"issued":{"date-parts":[[2026,5,26]]},"references-count":87,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2026,6,2]]}},"alternative-id":["10.1073\/pnas.2535704123"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2535704123","ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"2025-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2535704123"},{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:37:34Z","timestamp":1777426654923,"version":"3.51.4"},"reference-count":67,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["203077"],"award-info":[{"award-number":["203077"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["084538"],"award-info":[{"award-number":["084538"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["101910\/Z\/13\/Z"],"award-info":[{"award-number":["101910\/Z\/13\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G19\/9"],"award-info":[{"award-number":["G19\/9"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["091758"],"award-info":[{"award-number":["091758"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["202800"],"award-info":[{"award-number":["202800"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["084226"],"award-info":[{"award-number":["084226"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["067431"],"award-info":[{"award-number":["067431"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"abstract":"Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor One (CR1) gene, named Sl2 and McCb, occur at high frequencies, consistent with selection by malaria. Previous studies have been inconclusive. Using a large case-control study of severe malaria in Kenyan children and statistical models adjusted for confounders, we estimate the relationship between Sl2 and McCb and malaria phenotypes, and find they have opposing associations. The Sl2 polymorphism is associated with markedly reduced odds of cerebral malaria and death, while the McCb polymorphism is associated with increased odds of cerebral malaria. We also identify an apparent interaction between Sl2 and \u03b1+thalassaemia, with the protective association of Sl2 greatest in children with normal \u03b1-globin. The complex relationship between these three mutations may explain previous conflicting findings, highlighting the importance of considering genetic interactions in disease-association studies.<\/jats:p>","DOI":"10.7554\/elife.31579","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T20:00:11Z","timestamp":1524600011000},"source":"Crossref","is-referenced-by-count":29,"title":["Two complement receptor one alleles have opposing associations with cerebral malaria and interact with \u03b1+thalassaemia"],"prefix":"10.7554","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4589-4365","authenticated-orcid":true,"given":"D Herbert","family":"Opi","sequence":"first","affiliation":[{"name":"Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya"},{"name":"Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7386-2849","authenticated-orcid":true,"given":"Olivia","family":"Swann","sequence":"additional","affiliation":[{"name":"Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Macharia","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Uyoga","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Band","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyne M","family":"Ndila","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewen M","family":"Harrison","sequence":"additional","affiliation":[{"name":"Centre for Medical Infomatics, Usher Insitute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2679-035X","authenticated-orcid":true,"given":"Mahamadou A","family":"Thera","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Centre, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdoulaye K","family":"Kone","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Centre, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dapa A","family":"Diallo","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Centre, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ogobara K","family":"Doumbo","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Centre, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten E","family":"Lyke","sequence":"additional","affiliation":[{"name":"Division of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher V","family":"Plowe","sequence":"additional","affiliation":[{"name":"Division of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joann M","family":"Moulds","sequence":"additional","affiliation":[{"name":"Lifeshare Blood Centers, Shreveport, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Shebbe","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neema","family":"Mturi","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Peshu","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Maitland","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya"},{"name":"Department of Medicine, Imperial College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Raza","sequence":"additional","affiliation":[{"name":"Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic P","family":"Kwiatkowski","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom"},{"name":"Wellcome Trust Sanger Institute, Cambridge, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6369-9299","authenticated-orcid":true,"given":"Kirk A","family":"Rockett","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4456-2382","authenticated-orcid":true,"given":"Thomas N","family":"Williams","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya"},{"name":"Department of Medicine, Imperial College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7702-1892","authenticated-orcid":true,"given":"J Alexandra","family":"Rowe","sequence":"additional","affiliation":[{"name":"Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4374","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1182\/blood-2013-10-533489","article-title":"Epistasis between the haptoglobin common variant and \u03b1+thalassemia influences risk of severe malaria in Kenyan children","volume":"123","author":"Atkinson","year":"2014","journal-title":"Blood"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"e1003509","DOI":"10.1371\/journal.pgen.1003509","article-title":"Imputation-based meta-analysis of severe malaria in three African populations","volume":"9","author":"Band","year":"2013","journal-title":"PLoS Genetics"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting Linear Mixed-Effects Models Using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"Journal of Statistical Software"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"e15266","DOI":"10.7554\/eLife.15266","article-title":"Admixture into and within sub-Saharan Africa","volume":"5","author":"Busby","year":"2016","journal-title":"eLife"},{"key":"bib5","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood.V84.11.3909.bloodjournal84113909","article-title":"Natural protection against severe Plasmodium falciparum malaria due to impaired rosette formation","volume":"84","author":"Carlson","year":"1994","journal-title":"Blood"},{"key":"bib6","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1182\/blood.V95.1.360","article-title":"Single-tube multiplex-PCR screen for common deletional determinants of alpha-thalassemia","volume":"95","author":"Chong","year":"2000","journal-title":"Blood"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"e15085","DOI":"10.7554\/eLife.15085","article-title":"Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia","volume":"6","author":"Clarke","year":"2017","journal-title":"eLife"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1073\/pnas.0305306101","article-title":"A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria","volume":"101","author":"Cockburn","year":"2004","journal-title":"PNAS"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1537-2995.2007.01077.x","article-title":"Knops blood group haplotypes among distinct Brazilian populations","volume":"47","author":"Covas","year":"2007","journal-title":"Transfusion"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"987","DOI":"10.4269\/ajtmh.2009.09-0406","article-title":"High levels of Plasmodium falciparum rosetting in all clinical forms of severe malaria in African children","volume":"81","author":"Doumbo","year":"2009","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/1475-2875-9-119","article-title":"Candidate malaria susceptibility\/protective SNPs in hospital and population-based studies: the effect of sub-structuring","volume":"9","author":"Eid","year":"2010","journal-title":"Malaria Journal"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1038\/nature03631","article-title":"Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria","volume":"435","author":"Fairhurst","year":"2005","journal-title":"Nature"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1177\/1745691612462587","article-title":"The Long Way From \u03b1-Error Control to Validity Proper: Problems With a Short-Sighted False-Positive Debate","volume":"7","author":"Fiedler","year":"2012","journal-title":"Perspectives on Psychological Science : A Journal of the Association for Psychological Science"},{"key":"bib14","doi-asserted-by":"crossref","first-page":"330","DOI":"10.4269\/ajtmh.2004.71.330","article-title":"Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi","volume":"71","author":"Fitness","year":"2004","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1371\/journal.pmed.0050056","article-title":"Increased microerythrocyte count in homozygous alpha(+)-thalassaemia contributes to protection against severe malarial anaemia","volume":"5","author":"Fowkes","year":"2008","journal-title":"PLoS Medicine"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1093\/hmg\/ddm331","article-title":"Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria","volume":"17","author":"Fry","year":"2008","journal-title":"Human Molecular Genetics"},{"key":"bib17","first-page":"288","article-title":"Role of CR1 Knops polymorphism in the pathophysiology of malaria: Indian scenario","volume":"46","author":"Gandhi","year":"2009","journal-title":"Journal of Vector Borne Diseases"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1084\/jem.192.12.1797","article-title":"Complement receptor 1\/CD35 is a receptor for mannan-binding lectin","volume":"192","author":"Ghiran","year":"2000","journal-title":"The Journal of Experimental Medicine"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1159\/000108939","article-title":"Graphical tests for Hardy-Weinberg equilibrium based on the ternary plot","volume":"65","author":"Graffelman","year":"2008","journal-title":"Human Heredity"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1186\/1475-2875-12-400","article-title":"Human genetic polymorphisms in the Knops blood group are not associated with a protective advantage against Plasmodium falciparum malaria in Southern Ghana","volume":"12","author":"Hansson","year":"2013","journal-title":"Malaria Journal"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/ng.388","article-title":"Genome-wide and fine-resolution association analysis of malaria in West Africa","volume":"41","author":"Jallow","year":"2009","journal-title":"Nature Genetics"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1111\/epi.12173","article-title":"The genetic risk of acute seizures in African children with falciparum malaria","volume":"54","author":"Kariuki","year":"2013","journal-title":"Epilepsia"},{"key":"bib23","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1182\/blood.V78.3.812.812","article-title":"Rosetting of Plasmodium falciparum-infected red blood cells with uninfected red blood cells enhances microvascular obstruction under flow conditions","volume":"78","author":"Kaul","year":"1991","journal-title":"Blood"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"e37214","DOI":"10.1371\/journal.pone.0037214","article-title":"\u03b1-Thalassemia impairs the cytoadherence of Plasmodium falciparum-infected erythrocytes","volume":"7","author":"Krause","year":"2012","journal-title":"PLoS ONE"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1034\/j.1600-065X.2001.1800110.x","article-title":"Structure-function relationships of complement receptor type 1","volume":"180","author":"Krych-Goldberg","year":"2001","journal-title":"Immunological Reviews"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/S1471-4914(02)02419-X","article-title":"Human complement receptor type 1 (CR1) binds to a major malarial adhesin","volume":"8","author":"Krych-Goldberg","year":"2002","journal-title":"Trends in Molecular Medicine"},{"key":"bib27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4269\/ajtmh.2003.69.253","article-title":"Association of intraleukocytic Plasmodium falciparum malaria pigment with disease severity, clinical manifestations, and prognosis in severe malaria","volume":"69","author":"Lyke","year":"2003","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/nature15390","article-title":"A novel locus of resistance to severe malaria in a region of ancient balancing selection","volume":"526","author":"Malaria Genomic Epidemiology Network","year":"2015","journal-title":"Nature"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"e47463","DOI":"10.1371\/journal.pone.0047463","article-title":"Candidate human genetic polymorphisms and severe malaria in a Tanzanian population","volume":"7","author":"Manjurano","year":"2012","journal-title":"PLoS ONE"},{"key":"bib30","doi-asserted-by":"crossref","first-page":"734","DOI":"10.4269\/ajtmh.2003.68.734","article-title":"Spatial and temporal heterogeneity of Anopheles mosquitoes and Plasmodium falciparum transmission along the Kenyan coast","volume":"68","author":"Mbogo","year":"2003","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/j.1537-2995.2004.00615.x","article-title":"Identification of the Kna\/Knb polymorphism and a method for Knops genotyping","volume":"44","author":"Moulds","year":"2004","journal-title":"Transfusion"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"2879","DOI":"10.1182\/blood.V97.9.2879","article-title":"Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1","volume":"97","author":"Moulds","year":"2001","journal-title":"Blood"},{"key":"bib33","doi-asserted-by":"crossref","first-page":"2","DOI":"10.21307\/immunohematology-2019-193","article-title":"The Knops blood-group system: a review","volume":"26","author":"Moulds","year":"2010","journal-title":"Immunohematology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1093\/beheco\/arh107","article-title":"A farewell to Bonferroni: the problems of low statistical power and publication bias","volume":"15","author":"Nakagawa","year":"2004","journal-title":"Behavioral Ecology"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1111\/j.1537-2995.2011.03161.x","article-title":"Knops blood group polymorphism and susceptibility to Mycobacterium tuberculosis infection","volume":"51","author":"Noumsi","year":"2011","journal-title":"Transfusion"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1093\/ajcn\/80.6.1604","article-title":"Malaria and nutritional status in children living on the coast of Kenya","volume":"80","author":"Nyakeriga","year":"2004","journal-title":"The American Journal of Clinical Nutrition"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1016\/S0140-6736(08)61655-4","article-title":"Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya","volume":"372","author":"O'Meara","year":"2008","journal-title":"The Lancet"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ebiom.2014.10.006","article-title":"Mechanistic studies of the negative epistatic malaria-protective interaction between sickle cell trait and alphathalassemia","volume":"1","author":"Opi","year":"2014","journal-title":"EBioMedicine"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/gene.2016.2","article-title":"Red blood cell complement receptor one level varies with Knops blood group, \u03b1(+)thalassaemia and age among Kenyan children","volume":"17","author":"Opi","year":"2016","journal-title":"Genes & Immunity"},{"key":"bib40","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.4049\/jimmunol.141.11.3889","article-title":"Direct evidence for the clustered nature of complement receptors type 1 on the erythrocyte membrane","volume":"141","author":"Paccaud","year":"1988","journal-title":"Journal of Immunology"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"21242","DOI":"10.1073\/pnas.0910840106","article-title":"Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the Mediterranean","volume":"106","author":"Penman","year":"2009","journal-title":"PNAS"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1136\/bmj.316.7139.1236","article-title":"What's wrong with Bonferroni adjustments","volume":"316","author":"Perneger","year":"1998","journal-title":"BMJ"},{"key":"bib43","article-title":"R: A language and environment for statistical computing","author":"R Development Core Team","year":"2010","unstructured":"R Development Core Team. 2010. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. 2.11.1."},{"key":"bib44","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1038\/ng.3107","article-title":"Reappraisal of known malaria resistance loci in a large multicenter study","volume":"46","author":"Rockett","year":"2014","journal-title":"Nature Genetics"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/00001648-199001000-00010","article-title":"No adjustments are needed for multiple comparisons","volume":"1","author":"Rothman","year":"1990","journal-title":"Epidemiology"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1007\/s11606-013-2755-z","article-title":"Six persistent research misconceptions","volume":"29","author":"Rothman","year":"2014","journal-title":"Journal of General Internal Medicine"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1017\/S1462399409001082","article-title":"Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications","volume":"11","author":"Rowe","year":"2009","journal-title":"Expert Reviews in Molecular Medicine"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"17471","DOI":"10.1073\/pnas.0705390104","article-title":"Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting","volume":"104","author":"Rowe","year":"2007","journal-title":"PNAS"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/40888","article-title":"P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1","volume":"388","author":"Rowe","year":"1997","journal-title":"Nature"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"6341","DOI":"10.4049\/jimmunol.165.11.6341","article-title":"Mapping of the region of complement receptor (CR) 1 required for Plasmodium falciparum rosetting and demonstration of the importance of CR1 in rosetting in field isolates","volume":"165","author":"Rowe","year":"2000","journal-title":"The Journal of Immunology"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.molimm.2015.03.006","article-title":"More than just immune evasion: Hijacking complement by Plasmodium falciparum","volume":"67","author":"Schmidt","year":"2015","journal-title":"Molecular Immunology"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1093\/ije\/dys062","article-title":"Profile: The kilifi health and demographic surveillance system (KHDSS)","volume":"41","author":"Scott","year":"2012","journal-title":"International Journal of Epidemiology"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"e1000968","DOI":"10.1371\/journal.ppat.1000968","article-title":"Complement receptor 1 is a sialic acid-independent erythrocyte receptor of Plasmodium falciparum","volume":"6","author":"Spadafora","year":"2010","journal-title":"PLoS Pathogens"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"17825","DOI":"10.1038\/s41598-017-17664-9","article-title":"No evidence that knops blood group polymorphisms affect complement receptor 1 clustering on erythrocytes","volume":"7","author":"Swann","year":"2017","journal-title":"Scientific Reports"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"e34820","DOI":"10.1371\/journal.pone.0034820","article-title":"Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria","volume":"7","author":"Tetteh-Quarcoo","year":"2012","journal-title":"PLoS ONE"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1179\/2047773215Y.0000000011","article-title":"Severity of malaria in relation to a complement receptor 1 polymorphism: a case-control study","volume":"109","author":"Tettey","year":"2015","journal-title":"Pathogens and Global Health"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"17327","DOI":"10.1073\/pnas.1008151107","article-title":"Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand","volume":"107","author":"Tham","year":"2010","journal-title":"PNAS"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1475-2875-4-54","article-title":"Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya","volume":"4","author":"Thathy","year":"2005","journal-title":"Malaria Journal"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"e43987","DOI":"10.1371\/journal.pone.0043987","article-title":"Candidate polymorphisms and severe malaria in a Malian population","volume":"7","author":"Toure","year":"2012","journal-title":"PLoS ONE"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1093\/nar\/29.23.e119","article-title":"Single tube genotyping of sickle cell anaemia using PCR-based SNP analysis","volume":"29","author":"Waterfall","year":"2001","journal-title":"Nucleic Acids Research"},{"key":"bib61","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-98141-3","volume-title":"Ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2009"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1086\/430744","article-title":"Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases","volume":"192","author":"Williams","year":"2005","journal-title":"The Journal of Infectious Diseases"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1038\/ng1660","article-title":"Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait","volume":"37","author":"Williams","year":"2005","journal-title":"Nature Genetics"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1016\/S0140-6736(09)61374-X","article-title":"Bacteraemia in Kenyan children with sickle-cell anaemia: a retrospective cohort and case-control study","volume":"374","author":"Williams","year":"2009","journal-title":"The Lancet"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1182\/blood-2005-01-0313","article-title":"Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya","volume":"106","author":"Williams","year":"2005","journal-title":"Blood"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.humimm.2012.10.024","article-title":"The polymorphism of Knops blood group system in Korean population and their relationship with HLA system","volume":"74","author":"Yoon","year":"2013","journal-title":"Human Immunology"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/sj.gene.6363980","article-title":"CR1 Knops blood group alleles are not associated with severe malaria in the Gambia","volume":"4","author":"Zimmerman","year":"2003","journal-title":"Genes & Immunity"}],"container-title":["eLife"],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/31579\/elife-31579-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/31579\/elife-31579-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/31579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:48:46Z","timestamp":1697057326000},"score":9.846697,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/31579"}},"issued":{"date-parts":[[2018,4,25]]},"references-count":67,"alternative-id":["10.7554\/eLife.31579"],"URL":"https:\/\/doi.org\/10.7554\/elife.31579","archive":["CLOCKSS"],"relation":{"references":[{"id-type":"uri","id":"https:\/\/www.malariagen.net\/projects\/consortial-project-1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.31579.025","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.31579.024","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"published":{"date-parts":[[2018,4,25]]},"article-number":"e31579"},{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:40:03Z","timestamp":1778744403219,"version":"3.51.4"},"reference-count":64,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["108517"],"award-info":[{"award-number":["108517"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["200807"],"award-info":[{"award-number":["200807"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome","award":["103024"],"award-info":[{"award-number":["103024"]}]},{"name":"Wellcome","award":["219639"],"award-info":[{"award-number":["219639"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mBio"],"published-print":{"date-parts":[[2021,6,29]]},"abstract":"In eukaryotic cells, kinetochores are large protein complexes that link chromosomes to dynamic microtubule tips, ensuring proper segregation and genomic stability during cell division. Several proteins tightly coordinate kinetochore functions, including the protein kinase aurora kinase B.<\/jats:p>","DOI":"10.1128\/mbio.00687-21","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T13:09:26Z","timestamp":1623762566000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["A CLK1-KKT2 Signaling Pathway Regulating Kinetochore Assembly in Trypanosoma brucei"],"prefix":"10.1128","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6204-0460","authenticated-orcid":true,"given":"Manuel","family":"Saldivia","sequence":"first","affiliation":[{"name":"York Biomedical Research Institute, Department of Biology, University of York, Heslington, United Kingdom"},{"name":"Novartis Institute for Tropical Diseases, Emeryville, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5501-8131","authenticated-orcid":true,"given":"Adam J. M.","family":"Wollman","sequence":"additional","affiliation":[{"name":"York Biomedical Research Institute, Department of Biology, University of York, Heslington, United Kingdom"},{"name":"York Biomedical Research Institute, Department of Physics, University of York, Heslington, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2116-6379","authenticated-orcid":true,"given":"Juliana B. T.","family":"Carnielli","sequence":"additional","affiliation":[{"name":"York Biomedical Research Institute, Department of Biology, University of York, Heslington, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7328-4487","authenticated-orcid":true,"given":"Nathaniel G.","family":"Jones","sequence":"additional","affiliation":[{"name":"York Biomedical Research Institute, Department of Biology, University of York, Heslington, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1715-1249","authenticated-orcid":true,"given":"Mark C.","family":"Leake","sequence":"additional","affiliation":[{"name":"York Biomedical Research Institute, Department of Biology, University of York, Heslington, United Kingdom"},{"name":"York Biomedical Research Institute, Department of Physics, University of York, Heslington, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Bower-Lepts","sequence":"additional","affiliation":[{"name":"York Biomedical Research Institute, Department of Biology, University of York, Heslington, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7156-5725","authenticated-orcid":true,"given":"Srinivasa P. S.","family":"Rao","sequence":"additional","affiliation":[{"name":"Novartis Institute for Tropical Diseases, Emeryville, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5574-3766","authenticated-orcid":true,"given":"Jeremy C.","family":"Mottram","sequence":"additional","affiliation":[{"name":"York Biomedical Research Institute, Department of Biology, University of York, Heslington, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2718"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2310"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03472-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1139\/o06-078"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.10.019"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/biology6010005"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6976.12049"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2163"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2016.01.005"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e09-01-0065"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2033"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2013.01.010"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2009.0948"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.049"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.190236"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201608043"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky557"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.240978"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003886"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00712"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0745-6"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70243-X"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2008.04.004"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.27451"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05135"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201701025"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2018.02.005"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.154"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M800556-MCP200"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008129"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20170518"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200104096"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1242\/bio.031609"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.06.026"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00848-5"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000575"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2010.171"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.113.150839"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511504200"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002354"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06657.x"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03051"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.150206"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312862200"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300813200"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15421.1"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.12.4139-4149.2003"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.05.034"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11451"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau1682"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00113-10"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2018.00062"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00412-013-0401-5"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(00)01880-8"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200208091"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201901004"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201905144"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200509158"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201711181"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.08.022"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep18773"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2005.08.009"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.10.009"}],"container-title":["mBio"],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.00687-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mBio.00687-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T03:39:07Z","timestamp":1646710747000},"score":9.790218,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mBio.00687-21"}},"editor":[{"given":"Christian","family":"Tschudi","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"issued":{"date-parts":[[2021,6,29]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6,29]]}},"alternative-id":["10.1128\/mBio.00687-21"],"URL":"https:\/\/doi.org\/10.1128\/mbio.00687-21","ISSN":["2150-7511"],"issn-type":[{"value":"2150-7511","type":"electronic"}],"published":{"date-parts":[[2021,6,29]]},"assertion":[{"value":"2021-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00687-21"},{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T17:35:05Z","timestamp":1777138505441,"version":"3.51.4"},"posted":{"date-parts":[[2026,4,21]]},"group-title":"Cell Biology","reference-count":66,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wellcome","award":["220780"],"award-info":[{"award-number":["220780"]}]},{"name":"Wellcome","award":["319314"],"award-info":[{"award-number":["319314"]}]},{"name":"Wellcome","award":["218470"],"award-info":[{"award-number":["218470"]}]},{"name":"Wellcome","award":["203149"],"award-info":[{"award-number":["203149"]}]},{"name":"Wellcome","award":["226791"],"award-info":[{"award-number":["226791"]}]},{"id":[{"id":"https:\/\/ror.org\/00fzhcx31","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"accepted":{"date-parts":[[2026,4,21]]},"abstract":"Abstract<\/jats:title>\n \n Meiosis generates haploid gametes from a diploid progenitor. In meiosis I, homologous chromosomes segregate while sister chromatids co-orient toward the same spindle pole. The mechanisms underlying this specialized segregation pattern remain incompletely understood. Here we identify pathways required for meiosis I chromosome segregation through a forward genetic screen in\n Saccharomyces cerevisiae<\/jats:italic>\n . We find that meiosis I is highly sensitive to perturbations in diverse components of the segregation machinery and define key functional interfaces within complexes important for this division. These include meiosis I\u2013specific regulators that establish the specialized chromosome pattern, namely the monopolin complex that directs sister kinetochore co-orientation and the Spo13\n MOKIR<\/jats:sup>\n \u2013Cdc5\n Polo<\/jats:sup>\n module that promotes meiosis I chromosome segregation. In addition, we identify mutations affecting the core segregation machinery, including the spindle pole body, spindle midzone, and outer kinetochore, which can disrupt coupling between the chromosome segregation program and the meiotic spindle cycle. Together, our findings reveal that multiple pathways coordinate chromosome segregation with the meiotic divisions and highlight the unique demands of meiosis I.\n <\/jats:p>","DOI":"10.64898\/2026.04.17.719180","type":"posted-content","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:05:16Z","timestamp":1776816316000},"source":"Crossref","is-referenced-by-count":0,"title":["Multiple pathways couple kinetochore orientation to the meiotic spindle cycle"],"prefix":"10.64898","author":[{"given":"Aparna","family":"Vinod","sequence":"first","affiliation":[{"name":"Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, Michael Swann Building, Max Born Crescent, Edinburgh, EH9 3BF UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Turner","sequence":"additional","affiliation":[{"name":"Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, Michael Swann Building, Max Born Crescent, Edinburgh, EH9 3BF UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4956-3766","authenticated-orcid":false,"given":"Shaun","family":"Webb","sequence":"additional","affiliation":[{"name":"Discovery Research Platform for Hidden Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3596-9407","authenticated-orcid":false,"given":"Adele L.","family":"Marston","sequence":"additional","affiliation":[{"name":"Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, Michael Swann Building, Max Born Crescent, Edinburgh, EH9 3BF UK"},{"name":"Discovery Research Platform for Hidden Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026042509452281000_2026.04.17.719180v1.1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e06-10-0918"},{"key":"2026042509452281000_2026.04.17.719180v1.2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004666"},{"key":"2026042509452281000_2026.04.17.719180v1.3","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.74447"},{"key":"2026042509452281000_2026.04.17.719180v1.4","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201103076"},{"key":"2026042509452281000_2026.04.17.719180v1.5","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.117.300527"},{"key":"2026042509452281000_2026.04.17.719180v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.10.025"},{"key":"2026042509452281000_2026.04.17.719180v1.7","doi-asserted-by":"publisher","DOI":"10.1002\/yea.843"},{"key":"2026042509452281000_2026.04.17.719180v1.8","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00129-1"},{"key":"2026042509452281000_2026.04.17.719180v1.9","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E23-01-0014"},{"key":"2026042509452281000_2026.04.17.719180v1.10","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02583"},{"key":"2026042509452281000_2026.04.17.719180v1.11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.155242"},{"key":"2026042509452281000_2026.04.17.719180v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/ncb977"},{"key":"2026042509452281000_2026.04.17.719180v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.09.070"},{"key":"2026042509452281000_2026.04.17.719180v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.017"},{"key":"2026042509452281000_2026.04.17.719180v1.15","doi-asserted-by":"publisher","DOI":"10.1101\/gad.255554.114"},{"key":"2026042509452281000_2026.04.17.719180v1.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.05.032"},{"key":"2026042509452281000_2026.04.17.719180v1.17","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/163.1.47"},{"key":"2026042509452281000_2026.04.17.719180v1.18","doi-asserted-by":"publisher","DOI":"10.1128\/jb.104.1.202-210.1970"},{"key":"2026042509452281000_2026.04.17.719180v1.19","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.10507.1"},{"key":"2026042509452281000_2026.04.17.719180v1.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.04.003"},{"key":"2026042509452281000_2026.04.17.719180v1.21","doi-asserted-by":"publisher","DOI":"10.1002\/cpmb.103"},{"key":"2026042509452281000_2026.04.17.719180v1.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.08.054"},{"key":"2026042509452281000_2026.04.17.719180v1.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.12.020"},{"key":"2026042509452281000_2026.04.17.719180v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81876-0"},{"key":"2026042509452281000_2026.04.17.719180v1.25","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201103019"},{"key":"2026042509452281000_2026.04.17.719180v1.26","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E07-06-0584"},{"key":"2026042509452281000_2026.04.17.719180v1.27","doi-asserted-by":"publisher","DOI":"10.1038\/nature14097"},{"key":"2026042509452281000_2026.04.17.719180v1.28","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/genetics\/96.3.567","article-title":"Isolation of SPO12-1 and SPO13-1 from a natural variant of yeast that undergoes a single meiotic division","volume":"96","year":"1980","journal-title":"Genetics"},{"key":"2026042509452281000_2026.04.17.719180v1.29","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.110117"},{"key":"2026042509452281000_2026.04.17.719180v1.30","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1126\/science.1081846","article-title":"Role of Polo-like kinase CDC5 in programming meiosis I chromosome segregation","volume":"300","year":"2003","journal-title":"Science (New York, N.Y.)"},{"key":"2026042509452281000_2026.04.17.719180v1.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.12.033"},{"key":"2026042509452281000_2026.04.17.719180v1.32","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0061(199807)14:10<953::AID-YEA293>3.0.CO;2-U"},{"key":"2026042509452281000_2026.04.17.719180v1.33","doi-asserted-by":"publisher","DOI":"10.1093\/g3journal\/jkaf121"},{"key":"2026042509452281000_2026.04.17.719180v1.34","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/128.1.79"},{"key":"2026042509452281000_2026.04.17.719180v1.35","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00130-8"},{"key":"2026042509452281000_2026.04.17.719180v1.36","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094220"},{"key":"2026042509452281000_2026.04.17.719180v1.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.10.026"},{"key":"2026042509452281000_2026.04.17.719180v1.38","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12527"},{"key":"2026042509452281000_2026.04.17.719180v1.39","doi-asserted-by":"publisher","DOI":"10.15252\/EMBJ.2020106812"},{"key":"2026042509452281000_2026.04.17.719180v1.40","doi-asserted-by":"publisher","DOI":"10.1002\/yea.2967"},{"key":"2026042509452281000_2026.04.17.719180v1.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2024.07.025"},{"key":"2026042509452281000_2026.04.17.719180v1.42","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.17.2272"},{"key":"2026042509452281000_2026.04.17.719180v1.43","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201809138"},{"key":"2026042509452281000_2026.04.17.719180v1.44","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1401"},{"key":"2026042509452281000_2026.04.17.719180v1.45","doi-asserted-by":"publisher","DOI":"10.1016\/J.DEVCEL.2021.10.017"},{"key":"2026042509452281000_2026.04.17.719180v1.46","doi-asserted-by":"publisher","DOI":"10.1007\/BF00264206"},{"key":"2026042509452281000_2026.04.17.719180v1.47","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.6.1223"},{"key":"2026042509452281000_2026.04.17.719180v1.48","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00947"},{"key":"2026042509452281000_2026.04.17.719180v1.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.029"},{"key":"2026042509452281000_2026.04.17.719180v1.50","doi-asserted-by":"publisher","DOI":"10.1007\/s00412-019-00700-0"},{"key":"2026042509452281000_2026.04.17.719180v1.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.03.038"},{"key":"2026042509452281000_2026.04.17.719180v1.52","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00086-8"},{"key":"2026042509452281000_2026.04.17.719180v1.53","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00048-16"},{"key":"2026042509452281000_2026.04.17.719180v1.54","doi-asserted-by":"publisher","DOI":"10.1038\/nature07876"},{"key":"2026042509452281000_2026.04.17.719180v1.55","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256729"},{"key":"2026042509452281000_2026.04.17.719180v1.56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003610"},{"key":"2026042509452281000_2026.04.17.719180v1.57","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1808809"},{"key":"2026042509452281000_2026.04.17.719180v1.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.023"},{"key":"2026042509452281000_2026.04.17.719180v1.59","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1126\/science.289.5477.300","article-title":"Requirement of the spindle checkpoint for proper chromosome segregation in budding yeast meiosis","volume":"289","year":"2000","journal-title":"Science (New York, N.Y.)"},{"key":"2026042509452281000_2026.04.17.719180v1.60","doi-asserted-by":"publisher","DOI":"10.1101\/2025.08.19.671082"},{"key":"2026042509452281000_2026.04.17.719180v1.61","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00217-8"},{"key":"2026042509452281000_2026.04.17.719180v1.62","doi-asserted-by":"publisher","DOI":"10.1007\/BF00330883"},{"key":"2026042509452281000_2026.04.17.719180v1.63","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200308"},{"key":"2026042509452281000_2026.04.17.719180v1.64","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201694082"},{"key":"2026042509452281000_2026.04.17.719180v1.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.09.013"},{"key":"2026042509452281000_2026.04.17.719180v1.66","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.012905"}],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.04.17.719180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T16:45:38Z","timestamp":1777135538000},"score":9.786872,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.04.17.719180"}},"issued":{"date-parts":[[2026,4,21]]},"references-count":66,"URL":"https:\/\/doi.org\/10.64898\/2026.04.17.719180","published":{"date-parts":[[2026,4,21]]},"subtype":"preprint"},{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:34Z","timestamp":1772168974179,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.73900.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000}}],"reference-count":32,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["214185\/Z\/18\/Z"],"award-info":[{"award-number":["214185\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["103994\/Z\/14\/Z"],"award-info":[{"award-number":["103994\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["074833\/Z\/04\/Z"],"award-info":[{"award-number":["074833\/Z\/04\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome","award":["20517\/Z\/16\/Z"],"award-info":[{"award-number":["20517\/Z\/16\/Z"]}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"\n Background<\/ns3:bold>\n <\/ns3:p>\n The long-term impact of elevated blood pressure on mortality outcomes has been recently revisited due to proposed changes in cut-offs for hypertension. This study aimed at assessing the association between high blood pressure levels and 10-year mortality using the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) and the American College of Cardiology and the American Heart Association (ACC\/AHA) 2017 blood pressure guidelines.<\/ns3:p>\n \n Methods<\/ns3:bold>\n <\/ns3:p>\n Data of the PERU MIGRANT Study, a prospective ongoing cohort, was used. The outcome of interest was 10-year all-cause mortality, and exposures were blood pressure categories according to the JNC-7 and ACC\/AHA 2017 guidelines. Log-rank test, Kaplan-Meier and Cox regression models were used to assess the associations of interest controlling for confounders. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated.<\/ns3:p>\n \n Results<\/ns3:bold>\n <\/ns3:p>\n A total of 976 records, mean age of 60.4 (SD: 11.4), 513 (52.6%) women, were analyzed. Hypertension prevalence at baseline almost doubled from 16.0% (95% CI 13.7%\u201318.4%) to 31.3% (95% CI 28.4%\u201334.3%), using the JNC-7 and ACC\/AHA 2017 definitions, respectively. Sixty-three (6.4%) participants died during the 10-year follow-up, equating to a mortality rate of 3.6 (95% CI 2.4\u20134.7) per 1000 person-years. Using JNC-7, and compared to those with normal blood pressure, those with pre-hypertension and hypertension had 2-fold and 3.5-fold increased risk of death, respectively. Similar mortality effect sizes were estimated using ACC\/AHA 2017 for stage 1 and stage 2 hypertension.<\/ns3:p>\n \n Conclusions<\/ns3:bold>\n <\/ns3:p>\n Blood pressure levels under two different definitions increased the risk of 10-year all-cause mortality. Hypertension prevalence doubled using ACC\/AHA 2017 compared to JNC-7. The choice of blood pressure cut-offs to classify hypertension categories need to be balanced against the patients benefit and the capacities of the health system to adequately handle a large proportion of new patients.<\/ns3:p>","DOI":"10.12688\/f1000research.73900.2","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T12:40:13Z","timestamp":1673959213000},"page":"1134","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Blood pressure and 10-year all-cause mortality: Findings from the PERU MIGRANT Study"],"prefix":"10.12688","volume":"10","author":[{"given":"Aida","family":"Hidalgo-Benites","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Senosain-Leon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo M.","family":"Carrillo-Larco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ruiz-Alejos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Gilman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam","family":"Smeeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4738-5468","authenticated-orcid":false,"given":"J. Jaime","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-1376","authenticated-orcid":false,"given":"Antonio","family":"Bernab\u00e9-Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1603-1658","DOI":"10.1016\/S0140-6736(16)31460-X","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.","volume":"388","year":"2016","journal-title":"Lancet."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2224-2260","DOI":"10.1016\/S0140-6736(12)61766-8","article-title":"A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010.","volume":"380","author":"S Lim","year":"2012","journal-title":"Lancet."},{"key":"ref4","first-page":"37-55","article-title":"Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants.","volume":"389","year":"2017","journal-title":"Lancet."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1206-1252","DOI":"10.1161\/01.HYP.0000107251.49515.c2","article-title":"Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.","volume":"42","author":"A Chobanian","year":"2003","journal-title":"Hypertension."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e426-e483","DOI":"10.1161\/CIR.0000000000000597","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines.","volume":"138","author":"P Whelton","year":"2018","journal-title":"Circulation."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"956-960","DOI":"10.1016\/j.amjmed.2017.12.049","article-title":"Baseline Blood Pressure, the 2017 ACC\/AHA High Blood Pressure Guidelines, and Long-Term Cardiovascular Risk in SPRINT.","volume":"131","author":"M Vaduganathan","year":"2018","journal-title":"Am. J. Med."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"399-410","DOI":"10.23736\/S0026-4725.19.04965-X","article-title":"Implications of the new 2017 American College of Cardiology\/American Aeart Association Guidelines for Hypertension.","volume":"67","author":"W Aronow","year":"2019","journal-title":"Minerva Cardioangiol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"6382","DOI":"10.1038\/s41598-019-42809-3","article-title":"Status of Hypertension in Tehran: Potential impact of the ACC\/AHA 2017 and JNC7 Guidelines, 2012\u20132015.","volume":"9","author":"S Asgari","year":"2019","journal-title":"Sci. Rep."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"109-118","DOI":"10.1161\/CIRCULATIONAHA.117.032582","article-title":"Potential US Population Impact of the 2017 ACC\/AHA High Blood Pressure Guideline.","volume":"137","author":"P Muntner","year":"2018","journal-title":"Circulation."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s11906-019-0906-2","article-title":"Impact of the 2017 American College of Cardiology\/American Heart Association Blood Pressure Guidelines on the Next Blood Pressure Guidelines in Asia.","volume":"21","author":"N Nakagawa","year":"2019","journal-title":"Curr. Hypertens. Rep."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"545-556","DOI":"10.4067\/S0034-98872019000500545","article-title":"Changes in the prevalence of hypertension in Peru using the new guideline of the American College of Cardiology.","volume":"147","author":"A Hernandez-Vasquez","year":"2019","journal-title":"Rev. Med. Chil."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"668-670","DOI":"10.1177\/2047487318799489","article-title":"New 2017 ACC\/AHA hypertension guideline: Implications for a Latin American country like Peru.","volume":"26","author":"A Hern\u00e1ndez-V\u00e1squez","year":"2019","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1256-1264","DOI":"10.1161\/HYPERTENSIONAHA.106.083592","article-title":"Predictive utility of pulse pressure and other blood pressure measures for cardiovascular outcomes.","volume":"49","author":"W Mosley","year":"2007","journal-title":"Hypertension."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"345-354","DOI":"10.1177\/2047487319862066","article-title":"Associations of blood pressure categories defined by 2017 ACC\/AHA guidelines with mortality in China: Pooled results from three prospective cohorts.","volume":"27","author":"N Liu","year":"2020","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"678-685","DOI":"10.1111\/jch.12375","article-title":"Brachial pulse pressure and cardiovascular or all-cause mortality in the general population: a meta-analysis of prospective observational studies.","volume":"16","author":"L Zhao","year":"2014","journal-title":"J. Clin. Hypertens. (Greenwich)."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"775-781","DOI":"10.1001\/jamacardio.2017.1421","article-title":"Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Network Meta-analysis.","volume":"2","author":"J Bundy","year":"2017","journal-title":"JAMA Cardiol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e035190","DOI":"10.1136\/bmjopen-2019-035190","article-title":"Association between blood pressure levels and cardiovascular deaths: a 20-year follow-up study in rural China.","volume":"10","author":"M Wang","year":"2020","journal-title":"BMJ Open."},{"key":"ref19","first-page":"e123-e133","article-title":"Trends in cardiometabolic risk factors in the Americas between 1980 and 2014: a pooled analysis of population-based surveys.","volume":"8","year":"2020","journal-title":"Lancet Glob. Health."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1471-2261-9-23","article-title":"The effect on cardiovascular risk factors of migration from rural to urban areas in Peru: PERU MIGRANT Study.","volume":"9","author":"J Miranda","year":"2009","journal-title":"BMC Cardiovasc. Disord."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1752-f","DOI":"10.1093\/ije\/dyx116","article-title":"Cohort Profile: The PERU MIGRANT Study-A prospective cohort study of rural dwellers, urban dwellers and rural-to-urban migrants in Peru.","volume":"46","author":"R Carrillo-Larco","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.16811350.v3","article-title":"PERU MIGRANT Study. Figshare.","author":"J Miranda","year":"2021","journal-title":"Dataset."},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008548","article-title":"Nationwide Impact of the 2017 American College of Cardiology\/American Heart Association Blood Pressure Guidelines on Stroke Survivors.","volume":"7","author":"A Lekoubou","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1-3","DOI":"10.6515\/ACS.201801_34(1).20171218A","article-title":"Our Stance towards the 2017 ACC\/AHA High Blood Pressure Clinical Practice Guideline: Has the Pendulum Swung Too Far?.","volume":"34","author":"T Wang","year":"2018","journal-title":"Acta Cardiol. Sin."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"74-80","DOI":"10.1097\/HPC.0000000000000045","article-title":"Agreement Between Cardiovascular Disease Risk Scores in Resource-Limited Settings: Evidence from 5 Peruvian Sites.","volume":"14","author":"J Bazo-Alvarez","year":"2015","journal-title":"Crit. Pathw. Cardiol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"771-778","DOI":"10.3949\/ccjm.85a.18028","article-title":"2017 ACC\/AHA hypertension guidelines: Toward tighter control.","volume":"85","author":"R Blonsky","year":"2018","journal-title":"Cleve. Clin. J. Med."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jash.2018.01.004","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines.","volume":"12","author":"R Brook","year":"2018","journal-title":"J. Am. Soc. Hypertens."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1187-1197","DOI":"10.1016\/j.jacc.2018.05.074","article-title":"2017 ACC\/AHA Blood Pressure Treatment Guideline Recommendations and Cardiovascular Risk.","volume":"72","author":"L Colantonio","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"374-378","DOI":"10.1038\/s41591-020-0754-2","article-title":"Effect of salt substitution on community-wide blood pressure and hypertension incidence.","volume":"26","author":"A Bernabe-Ortiz","year":"2020","journal-title":"Nat. Med."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"507-520","DOI":"10.1001\/jama.2013.284427","article-title":"2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8).","volume":"311","author":"P James","year":"2014","journal-title":"JAMA."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"327-334","DOI":"10.1161\/HYPERTENSIONAHA.118.12291","article-title":"Cardiovascular Disease and Mortality in Adults Aged >\/=60 Years According to Recommendations by the American College of Cardiology\/American Heart Association and American College of Physicians\/American Academy of Family Physicians.","volume":"73","author":"B Jaeger","year":"2019","journal-title":"Hypertension."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"572-581","DOI":"10.1001\/jamacardio.2018.1240","article-title":"Estimating the Association of the 2017 and 2014 Hypertension Guidelines With Cardiovascular Events and Deaths in US Adults: An Analysis of National DataAssociation of the 2014 and 2017 Hypertension Guidelines With Cardiovascular Events and Deaths in US AdultsAssociation of the 2014 and 2017 Hypertension Guidelines With Cardiovascular Events and Deaths in US Adults.","volume":"3","author":"J Bundy","year":"2018","journal-title":"JAMA Cardiol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"114-119","DOI":"10.4103\/aam.aam_6_17","article-title":"A profile of adverse effects of antihypertensive medicines in a tertiary care clinic in Nigeria.","volume":"16","author":"A Olowofela","year":"2017","journal-title":"Ann. Afr. Med."}],"updated-by":[{"DOI":"10.12688\/f1000research.73900.4","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000}},{"DOI":"10.12688\/f1000research.73900.3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000}}],"container-title":["F1000Research"],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/10-1134\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-1134\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-1134\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T04:25:25Z","timestamp":1701059125000},"score":9.786638,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/10-1134\/v2"}},"issued":{"date-parts":[[2023,1,17]]},"references-count":32,"URL":"https:\/\/doi.org\/10.12688\/f1000research.73900.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.142808.r160523","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.142808.r160523","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"published":{"date-parts":[[2023,1,17]]},"assertion":[{"value":"Approved with reservations","URL":"https:\/\/f1000research.com\/articles\/10-1134\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.142808.r160523, Annika Hoyer, Dina Voeltz, Biostatistics and Medical Biometry, Medical School OWL, Bielefeld University, Bielefeld, 24 Jan 2023, version 2, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/10-1134\/v2#referee-response-160523","order":0,"name":"referee-response-160523","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Antonio Bernabe-Ortiz<\/b>; \nPosted: 04 Apr 2023<\/i>; \n1. We do now understand the age cut-off at year 30 and thank the authors for clarification. Nonetheless, we are wondering how the new categorization is justified. With regards to blood pressure and mortality, we would think that particularly the age group 60+ might be at high risk and thus, more detailed analysis (i.e., splitting into further age group 60-69, 70-79, etc.) might be of interest. We kindly ask the authors for more details on the stratification choice. Overall, though, we still recommend including age as a covariate measured on a continuous scale to improve the power of the analysis.<\/b> \nResponse:<\/i><\/b> The categorization of the age variable is due to the fact that the sampling approach was stratified by age in that way (i.e., 30-39, 40-49, 50-59, and 60+). For instance, even we can adjust for that variable in different forms (i.e., using different cut-offs or in a continuous fashion), the best way would be to adjust for the form the variable was stratified. This was explained in the \u201cSettings and participants\u201d subheading in the Methods section. In addition, this was added in the Statistical analysis subheading: \u201c\nPotential confounders were selected under epidemiological criteria. Since the selection of the participant\u2019s sample was stratified by age (i.e., 30-39, 40-49, 50-59, 60+), such variable was included in that form in adjusted models.<\/i>\u201d \n2. Current guidelines used to report the results of observational studies such as STROBE clearly state that inferential measures should not be used for description of the study population. In line with that, we strongly suggest to delete all p-values from tables 1-3 and to simply describe the characteristics of the study participants. Further, and also as advanced by current guidelines, the use of p-values is not an appropriate criterion for selecting which confounders to adjust for in the analysis. Consequently, we advocate that any statement about potential associations based on single p-values should be avoided.<\/b> \nResponse:<\/i><\/b> We have deleted p-values from tables 1 to 3 as suggested. We have not selected confounders based on p-values, but in an epidemiological approach (pre-specified model). \n3. We thank the authors for rewriting the Statistical analysis section where they refer to the Kaplan-Meier estimator. In the text it now reads that the evaluation of the proportional hazard assumption is based on visual inspection of a graph. For higher transparency and better understanding, we would suggest to include the graph in the article or as supporting material.<\/b> \nResponse:<\/i><\/b>\n <\/b>We have included the figure in the manuscript as requested. We believe the figure does not add more information. Thus, we think the figure should be included in online material but F1000Research does not accept supplemental material. We leave the final decision to include the figure to the reviewer and the editor. \n4. We are pleased to see that the authors followed our recommendation and changed the term \u201cbivariate model\u201d. Though, the term \u201cbivariable model\u201d is still somewhat misleading and rather uncommon to use. We would suggest to simply refer to an \u201cassociation\u201d.<\/b> \nResponse:<\/i><\/b> We have deleted the word bivariable from the text of the manuscript. \n5. As suggested by the authors, we have reviewed the Public health relevance section for more information on how their study provides input e.g. for local decision making or public health implications. From our point of view, the article still lacks precise guidance in which way the estimates\/results from the study presented in the article can be used for decision making with respect to benefits and risks for patients with newly diagnosed hypertension. Consequently, we highly recommend that the authors explain the implications of their study in more detail and that they provide concrete ideas of possible future activities.<\/b> \nResponse:<\/i><\/b> This is an observational study looking at the association between two different guidelines for hypertension definition and all-cause mortality, and not a clinical trial to do decision making. However, according to our results, we have added some lines: \n\u201cTreatment must be guaranteed for hypertension (using JNC-7) and stage 2 hypertension (ACC\/AHA 2017) to reduce mortality risk. If this effect can be seen in pre-hypertension (JNC-7) and stage 1 hypertension (ACC\/AHA 2017) should be further assessed.\u201d<\/i> \n6. In our first review we noted that the authors were not consistent in their writing and with the vocabulary used in the tables, e.g. "stage 1" vs. "stage-1" vs. "stage I" (same applies for \u201cstage 2\u201d). In the reviewed article we still find inconsistencies, particularly comparing the Public health relevance section with the rest of the text.<\/b> \nResponse:<\/i><\/b> We have reviewed through manuscript, tables and figures to keep consistency.","URL":"https:\/\/f1000research.com\/articles\/10-1134\/v2#referee-comment-9541","order":1,"name":"referee-comment-9541","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"RMC-L is supported by a Wellcome Trust International Training Fellowship, London, UK (214185\/Z\/18\/Z). AB-O (103994\/Z\/14\/Z) and JJM (074833\/Z\/04\/Z, 20517\/Z\/16\/Z) were supported by the Wellcome Trust, London, UK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]},{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:42:12Z","timestamp":1770039732398,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["2\/226120\/Z\/22\/Z"],"award-info":[{"award-number":["2\/226120\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["2\/226120\/Z\/22\/Z"],"award-info":[{"award-number":["2\/226120\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["2\/226120\/Z\/22\/Z"],"award-info":[{"award-number":["2\/226120\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["2\/226120\/Z\/22\/Z"],"award-info":[{"award-number":["2\/226120\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["2\/226120\/Z\/22\/Z"],"award-info":[{"award-number":["2\/226120\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["2\/226120\/Z\/22\/Z"],"award-info":[{"award-number":["2\/226120\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["2\/226120\/Z\/22\/Z"],"award-info":[{"award-number":["2\/226120\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["222574\/Z\/21\/Z"],"award-info":[{"award-number":["222574\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["2\/226120\/Z\/22\/Z"],"award-info":[{"award-number":["2\/226120\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["2\/226120\/Z\/22\/Z"],"award-info":[{"award-number":["2\/226120\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["2\/226120\/Z\/22\/Z"],"award-info":[{"award-number":["2\/226120\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["2\/226120\/Z\/22\/Z"],"award-info":[{"award-number":["2\/226120\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"Abstract<\/jats:title>\n Background<\/jats:title>\n Data on the dynamics and persistence of humoral immunity against SARS-CoV-2 after primary vaccination with two-dose inactivated vaccine (CoronaVac) are limited. This study evaluated the sequential effects of prior infection, heterologous boosting with mRNA-1273 (Moderna), and the occurrence of Omicron vaccine-breakthrough infection (VBI) thereafter.<\/jats:p>\n <\/jats:sec>\n Methods<\/jats:title>\n We evaluated anti-spike IgG (Abbott) and neutralising (cPASS\/GenScript) antibody (nAb) titers up to one year after mRNA-1273 boost in two-dose-CoronaVac-primed Indonesian healthcare workers (August 2021-August 2022). We used linear mixed modeling to estimate the rate of change in antibody levels, and logistic regression to examine associations between antibody levels and VBI.<\/jats:p>\n <\/jats:sec>\n Results<\/jats:title>\n Of 138 participants, 52 (37.7%) had a prior infection and 78 (56.5%) received an mRNA-1273 booster. After two-dose CoronaVac, antibody titers had significantly declined within 180\u00a0days, irrespective of prior infection. After mRNA-1273 booster, anti-spike IgG (1.47% decline\/day) and Omicron B.1.1.529\/BA.2 nAbs declined between day 28\u201390, and IgG titers plateaued between day 90\u2013360. During the BA.1\/BA.2 wave (February\u2013March 2022), 34.6% (27\/78) of individuals experienced a VBI (median 181\u00a0days after mRNA-1273), although none developed severe illness. VBI was associated with low pre-VBI anti-spike IgG and B.1.1.529\/BA.2 nAbs, which were restored post-VBI.<\/jats:p>\n <\/jats:sec>\n Conclusions<\/jats:title>\n mRNA-1273 booster after two-dose CoronaVac did not prevent BA.1\/BA.2 VBI. Periodic vaccine boosters may be warranted against emerging SARS-CoV-2 variants.<\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s12879-024-09644-y","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T09:03:13Z","timestamp":1722502993000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anti-SARS-CoV-2 antibody dynamics after primary vaccination with two-dose inactivated whole-virus vaccine, heterologous mRNA-1273 vaccine booster, and Omicron breakthrough infection in Indonesian health care workers"],"prefix":"10.1186","volume":"24","author":[{"given":"Suwarti","family":"Suwarti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"Lazarus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabighoh","family":"Zanjabila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Sinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fransiska","family":"Fransiska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresia","family":"Deborah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dwi","family":"Oktavia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junaidah","family":"Junaidah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santayana","family":"Santayana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Surendra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeng","family":"Yuliana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herlina","family":"Pardosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nunung","family":"Nuraeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saraswati","family":"Soebianto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Novi Dwi","family":"Susilowati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Decy","family":"Subekti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel","family":"Pradipta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Kevin","family":"Baird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Van","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Dunachie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuraj H.","family":"Shankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erni J.","family":"Nelwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raph L.","family":"Hamers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"SEACOVARIANTS Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen To","family":"Anh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi Thu","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Truong Hoang Chau","family":"Truc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi Han","family":"Ny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Duong Kim","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Kim","family":"Thanh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lam Anh","family":"Nguyet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cao Thu","family":"Thuy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Nguyen Truc","family":"Nhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Tan","family":"Thanh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lam Minh","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vu Thi\u00a0Ty","family":"Hang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pham Tieu","family":"Kieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vo Tan","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi","family":"Thao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vu Duy","family":"Thanh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Chieu","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Louise","family":"Thwaites","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Thwaites","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Rogier","family":"van Doorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trinh Son","family":"Tung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juthathip","family":"Mongkolsapaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Screaton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiete","family":"Dijokaite-Guraliuc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raksha","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyada","family":"Supasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneeswaran","family":"Selvaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna J.","family":"Dunachie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Klenerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Yvonne","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David I.","family":"Stuart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Kronsteiner-Dobramysl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Zewdie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanie","family":"Tayipto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isana","family":"Paramita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Lin-Fa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tan Chee","family":"Wah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yap Wee","family":"Chee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lim Beng","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Suwarti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Simarmata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragil","family":"Dien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanwisa","family":"Dejnirattisai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warangkana","family":"Chantima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narisara","family":"Chantratita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prapassorn","family":"Poolchanuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vichapon","family":"Tiacharoen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adul","family":"Dulsuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophon","family":"Iamsirithaworn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Day","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phaik Yeong","family":"Cheah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tassawan","family":"Poomchaichote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanpong","family":"Boonthaworn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nghiem My","family":"Ngoc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Grifoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"9644_CR1","doi-asserted-by":"publisher","first-page":"e0000893","DOI":"10.1371\/journal.pgph.0000893","volume":"2","author":"LL Ekawati","year":"2022","unstructured":"Ekawati LL, Arif A, Hidayana I, Nurhasim A, Munziri MZ, Lestari KD, et al. Mortality among healthcare workers in Indonesia during 18 months of COVID-19. PLOS Glob Public Heal. 2022;2:e0000893. https:\/\/doi.org\/10.1371\/journal.pgph.0000893.","journal-title":"PLOS Glob Public Heal"},{"key":"9644_CR2","doi-asserted-by":"publisher","unstructured":"Levin EG, Lustig Y, Cohen C, Fluss R, Indenbaum V, Amit S, et al. Waning immune humoral response to BNT162b2 Covid-19 Vaccine over 6 Months. N Engl J Med. 2021;385:e84. https:\/\/doi.org\/10.1056\/NEJMoa2114583.","DOI":"10.1056\/NEJMoa2114583"},{"key":"9644_CR3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2114114","author":"H Chemaitelly","year":"2021","unstructured":"Chemaitelly H, Tang P, Hasan MR, AlMukdad S, Yassine HM, Benslimane FM, et al. Waning of BNT162b2 Vaccine Protection against SARS-CoV-2 Infection in Qatar. N Engl J Med. 2021. https:\/\/doi.org\/10.1056\/NEJMoa2114114.","journal-title":"N Engl J Med"},{"key":"9644_CR4","doi-asserted-by":"publisher","unstructured":"Andrews N, Stowe J, Kirsebom F, Toffa S, Rickeard T, Gallagher E, et al. Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant. N Engl J Med. 2022;386:1532\u201346. https:\/\/doi.org\/10.1056\/NEJMoa2119451.","DOI":"10.1056\/NEJMoa2119451"},{"key":"9644_CR5","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0140-6736(22)00094-0","volume":"399","author":"SA Costa Clemens","year":"2022","unstructured":"Costa Clemens SA, Weckx L, Clemens R, Almeida Mendes AV, Ramos Souza A, Silveira MBV, et al. Heterologous versus homologous COVID-19 booster vaccination in previous recipients of two doses of CoronaVac COVID-19 vaccine in Brazil (RHH-001): a phase 4, non-inferiority, single blind, randomised study. Lancet. 2022;399:521\u20139. https:\/\/doi.org\/10.1016\/S0140-6736(22)00094-0.","journal-title":"Lancet"},{"key":"9644_CR6","doi-asserted-by":"publisher","unstructured":"Jara A, Undurraga EA, Gonz\u00e1lez C, Paredes F, Fontecilla T, Jara G, et al. Effectiveness of an Inactivated SARS-CoV-2 vaccine in Chile. N Engl J Med. 2021;385:875\u201384. https:\/\/doi.org\/10.1056\/NEJMoa2107715.","DOI":"10.1056\/NEJMoa2107715"},{"key":"9644_CR7","doi-asserted-by":"publisher","first-page":"e423","DOI":"10.1016\/S2666-5247(21)00177-4","volume":"2","author":"WW Lim","year":"2021","unstructured":"Lim WW, Mak L, Leung GM, Cowling BJ, Peiris M. Comparative immunogenicity of mRNA and inactivated vaccines against COVID-19. Lancet Microbe. 2021;2:e423. https:\/\/doi.org\/10.1016\/S2666-5247(21)00177-4.","journal-title":"Lancet Microbe"},{"key":"9644_CR8","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S1473-3099(21)00479-5","volume":"22","author":"D Saur\u00e9","year":"2022","unstructured":"Saur\u00e9 D, O\u2019Ryan M, Torres JP, Zuniga M, Santelices E, Basso LJ. Dynamic IgG seropositivity after rollout of CoronaVac and BNT162b2 COVID-19 vaccines in Chile: a sentinel surveillance study. Lancet Infect Dis. 2022;22:56\u201363. https:\/\/doi.org\/10.1016\/S1473-3099(21)00479-5.","journal-title":"Lancet Infect Dis"},{"key":"9644_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2023.1255676","volume":"14","author":"J Sembera","year":"2023","unstructured":"Sembera J, Baine C, Ankunda V, Katende JS, Oluka GK, Akoli CH, et al. Sustained spike-specific IgG antibodies following CoronaVac (Sinovac) vaccination in sub-Saharan Africa, but increased breakthrough infections in baseline spike-naive individuals. Front Immunol. 2023;14:1\u201312. https:\/\/doi.org\/10.3389\/fimmu.2023.1255676.","journal-title":"Front Immunol."},{"key":"9644_CR10","doi-asserted-by":"publisher","first-page":"e149","DOI":"10.1016\/S2666-5247(22)00290-7","volume":"4","author":"D Saur\u00e9","year":"2023","unstructured":"Saur\u00e9 D, O\u2019Ryan M, Torres JP, Zu\u00f1iga M, Soto-Rifo R, Valiente-Echeverr\u00eda F, et al. COVID-19 lateral flow IgG seropositivity and serum neutralising antibody responses after primary and booster vaccinations in Chile: a cross-sectional study. Lancet Microbe. 2023;4:e149\u201358. https:\/\/doi.org\/10.1016\/S2666-5247(22)00290-7.","journal-title":"Lancet Microbe"},{"key":"9644_CR11","doi-asserted-by":"publisher","unstructured":"Reynolds CJ, Pade C, Gibbons JM, Otter AD, Lin KM, Sandoval DM, et al. Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure. Science (80- ). 2022;377. https:\/\/doi.org\/10.1126\/science.abq1841.","DOI":"10.1126\/science.abq1841"},{"key":"9644_CR12","doi-asserted-by":"publisher","unstructured":"Sinto R, Utomo D, Suwarti, Nelwan EJ, Surendra H, Natasha C, et al. Antibody responses and reactogenicity of a heterologous, full-dose messenger RNA-1273 booster in heavily SARS-CoV-2\u2013exposed Coronavac-vaccinated health-care workers in Indonesia: A real-world observational study. Am J Trop Med Hyg. 2023;108:115\u201323. https:\/\/doi.org\/10.4269\/ajtmh.22-0256.","DOI":"10.4269\/ajtmh.22-0256"},{"key":"9644_CR13","doi-asserted-by":"publisher","first-page":"100603","DOI":"10.1016\/j.xcrm.2022.100603","volume":"3","author":"G Mantus","year":"2022","unstructured":"Mantus G, Nyhoff LE, Edara V-V, Zarnitsyna VI, Ciric CR, Flowers MW, et al. Pre-existing SARS-CoV-2 immunity influences potency, breadth, and durability of the humoral response to SARS-CoV-2 vaccination. Cell Reports Med. 2022;3:100603. https:\/\/doi.org\/10.1016\/j.xcrm.2022.100603.","journal-title":"Cell Reports Med"},{"key":"9644_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/v15040917","volume":"15","author":"J Wang","year":"2023","unstructured":"Wang J, Huang L, Guo N, Yao YP, Zhang C, Xu R, et al. Dynamics of SARS-CoV-2 antibody responses up to 9 months post-vaccination in individuals with previous SARS-CoV-2 infection receiving inactivated vaccines. Viruses. 2023;15:1\u201316. https:\/\/doi.org\/10.3390\/v15040917.","journal-title":"Viruses"},{"key":"9644_CR15","doi-asserted-by":"publisher","first-page":"e0266701","DOI":"10.1371\/journal.pone.0266701","volume":"17","author":"JR Richardson","year":"2022","unstructured":"Richardson JR, G\u00f6tz R, Mayr V, Lohse MJ, Holthoff H-P, Ungerer M. SARS-CoV2 wild type and mutant specific humoral and T cell immunity is superior after vaccination than after natural infection. PLoS ONE. 2022;17:e0266701. https:\/\/doi.org\/10.1371\/journal.pone.0266701.","journal-title":"PLoS ONE"},{"key":"9644_CR16","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.cell.2022.01.018","volume":"185","author":"K R\u00f6ltgen","year":"2022","unstructured":"R\u00f6ltgen K, Nielsen SCA, Silva O, Younes SF, Zaslavsky M, Costales C, et al. Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination. Cell. 2022;185:1025-1040.e14. https:\/\/doi.org\/10.1016\/j.cell.2022.01.018.","journal-title":"Cell"},{"key":"9644_CR17","doi-asserted-by":"publisher","unstructured":"Kaku CI, Champney ER, Normark J, Garcia M, Johnson CE, Ahlm C, et al. Broad anti\u2013SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1\/mRNA-1273 vaccination. Science (80- ). 2022;375:1041\u20137. https:\/\/doi.org\/10.1126\/science.abn2688.","DOI":"10.1126\/science.abn2688"},{"key":"9644_CR18","doi-asserted-by":"crossref","unstructured":"Gilboa M, Regev-Yochay G, Mandelboim M, Indenbaum V, Asraf K, Fluss R, et al. Durability of immune response after COVID-19 booster vaccination and association with COVID-19 omicron infection. JAMA Netw open. 2022;5:e2231778. https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.31778.","DOI":"10.1001\/jamanetworkopen.2022.31778"},{"key":"9644_CR19","doi-asserted-by":"publisher","unstructured":"Gilboa M, Gonen T, Barda N, Cohn S, Indenbaum V, Weiss-Ottolenghi Y, et al. Factors associated with protection from SARS-CoV-2 omicron variant infection and disease among vaccinated health care workers in Israel. JAMA Netw open. 2023;6:e2314757. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.14757.","DOI":"10.1001\/jamanetworkopen.2023.14757"},{"key":"9644_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01705-6","author":"E P\u00e9rez-Then","year":"2022","unstructured":"P\u00e9rez-Then E, Lucas C, Monteiro VS, Miric M, Brache V, Cochon L, et al. Neutralizing antibodies against the SARS-CoV-2 Delta and Omicron variants following heterologous CoronaVac plus BNT162b2 booster vaccination. Nat Med. 2022. https:\/\/doi.org\/10.1038\/s41591-022-01705-6.","journal-title":"Nat Med"},{"key":"9644_CR21","doi-asserted-by":"publisher","first-page":"E2228900","DOI":"10.1001\/jamanetworkopen.2022.28900","volume":"5","author":"OT Ng","year":"2022","unstructured":"Ng OT, Marimuthu K, Lim N, Lim ZQ, Thevasagayam NM, Koh V, et al. Analysis of COVID-19 Incidence and Severity among Adults Vaccinated with 2-Dose mRNA COVID-19 or Inactivated SARS-CoV-2 Vaccines with and Without Boosters in Singapore. JAMA Netw Open. 2022;5:E2228900. https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.28900.","journal-title":"JAMA Netw Open"},{"key":"9644_CR22","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1016\/S1473-3099(22)00345-0","volume":"22","author":"ME McMenamin","year":"2022","unstructured":"McMenamin ME, Nealon J, Lin Y, Wong JY, Cheung JK, Lau EHY, et al. Vaccine effectiveness of one, two, and three doses of BNT162b2 and CoronaVac against COVID-19 in Hong Kong: a population-based observational study. Lancet Infect Dis. 2022;22:1435\u201343. https:\/\/doi.org\/10.1016\/S1473-3099(22)00345-0.","journal-title":"Lancet Infect Dis"},{"key":"9644_CR23","doi-asserted-by":"publisher","first-page":"100348","DOI":"10.1016\/j.lansea.2023.100348","volume":"22","author":"A Karuniawati","year":"2024","unstructured":"Karuniawati A, Pasaribu AP, Lazarus G, Irawany V, Nusantara DU, Sinto R, et al. Characteristics and clinical outcomes of patients with pre-delta, delta and omicron SARS-CoV-2 infection in Indonesia (2020\u20132023): a multicentre prospective cohort study. Lancet Reg Heal - Southeast Asia. 2024;22:100348. https:\/\/doi.org\/10.1016\/j.lansea.2023.100348.","journal-title":"Lancet Reg Heal - Southeast Asia"},{"key":"9644_CR24","doi-asserted-by":"publisher","unstructured":"Chen Y, Zhao T, Chen L, Jiang G, Geng Y, Li W, et al. SARS-CoV-2 Omicron infection augments the magnitude and durability of systemic and mucosal immunity in triple-dose CoronaVac recipients. MBio. 2024:e0240723. https:\/\/doi.org\/10.1128\/mbio.02407-23b.","DOI":"10.1128\/mbio.02407-23b"},{"key":"9644_CR25","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1038\/s41591-023-02503-4","volume":"29","author":"AR Branche","year":"2023","unstructured":"Branche AR, Rouphael NG, Diemert DJ, Falsey AR, Losada C, Baden LR, et al. Comparison of bivalent and monovalent SARS-CoV-2 variant vaccines: the phase 2 randomized open-label COVAIL trial. Nat Med. 2023;29:2334\u201346. https:\/\/doi.org\/10.1038\/s41591-023-02503-4.","journal-title":"Nat Med"},{"key":"9644_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-023-38892-w","volume":"14","author":"S Chalkias","year":"2023","unstructured":"Chalkias S, Harper C, Vrbicky K, Walsh SR, Essink B, Brosz A, et al. Three-month antibody persistence of a bivalent Omicron-containing booster vaccine against COVID-19. Nat Commun. 2023;14:1\u20137. https:\/\/doi.org\/10.1038\/s41467-023-38892-w.","journal-title":"Nat Commun"},{"key":"9644_CR27","doi-asserted-by":"publisher","unstructured":"Ho-Yan Fong C, Zhang X, Chen LL, Wing-Shan Poon R, Pui-Chun Chan B, Zhao Y, et al. Effect of vaccine booster, vaccine type, and hybrid immunity on humoral and cellular immunity against SARS-CoV-2 ancestral strain and Omicron variant sublineages BA.2 and BA.5 among older adults with comorbidities: a cross sectional study. eBioMedicine. 2023;88:104446. https:\/\/doi.org\/10.1016\/j.ebiom.2023.104446.","DOI":"10.1016\/j.ebiom.2023.104446"},{"key":"9644_CR28","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1038\/s41590-022-01313-z","volume":"23","author":"N Brasu","year":"2022","unstructured":"Brasu N, Elia I, Russo V, Montacchiesi G, Stabile SA, De Intinis C, et al. Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination. Nat Immunol. 2022;23:1445\u201356. https:\/\/doi.org\/10.1038\/s41590-022-01313-z.","journal-title":"Nat Immunol"},{"key":"9644_CR29","doi-asserted-by":"publisher","unstructured":"M\u00e9ndez C, Pe\u00f1aloza HF, Schultz BM, Pi\u00f1a-Iturbe A, R\u00edos M, Moreno-Tapia D, et al. Humoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adults. eBioMedicine. 2023;91:1\u201314. https:\/\/doi.org\/10.1016\/j.ebiom.2023.104563.","DOI":"10.1016\/j.ebiom.2023.104563"},{"key":"9644_CR30","doi-asserted-by":"publisher","unstructured":"Lasrado N, Collier A ris Y, Hachmann NP, Miller J, Rowe M, Schonberg ED, et al. Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86. Vaccine. 2023;41:6904\u20139. https:\/\/doi.org\/10.1016\/j.vaccine.2023.10.051.","DOI":"10.1016\/j.vaccine.2023.10.051"}],"container-title":["BMC Infectious Diseases"],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-024-09644-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-024-09644-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-024-09644-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T09:04:49Z","timestamp":1722503089000},"score":9.770147,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-024-09644-y"}},"issued":{"date-parts":[[2024,8,1]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["9644"],"URL":"https:\/\/doi.org\/10.1186\/s12879-024-09644-y","ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"published":{"date-parts":[[2024,8,1]]},"assertion":[{"value":"8 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The INVITE study was approved by the research ethics committee of the Faculty of Medicine Universitas Indonesia (841\/UN2.F1.ETIK\/PPM.00.02\/2021) and the Oxford Tropical Research Ethics Committee (22\u201321). All participants provided written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"768"},{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:03:42Z","timestamp":1777572222496,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["223195\/Z\/21\/Z"],"award-info":[{"award-number":["223195\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["223195\/Z\/21\/Z"],"award-info":[{"award-number":["223195\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Other"],"award-info":[{"award-number":["Other"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"Abstract<\/jats:title>\n \n Brief summary<\/jats:title>\n In early symptomatic COVID-19 treatment, high dose oral favipiravir did not accelerate viral clearance.<\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n Favipiravir, an anti-influenza drug, has in vitro antiviral activity against SARS-CoV-2. Clinical trial evidence to date is inconclusive. Favipiravir has been recommended for the treatment of COVID-19 in some countries.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In a multicentre open-label, randomised, controlled, adaptive platform trial, low-risk adult patients with early symptomatic COVID-19 were randomised to one of ten treatment arms including high dose oral favipiravir (3.6g on day 0 followed by 1.6g daily to complete 7 days treatment) or no study drug. The primary outcome was the rate of viral clearance (derived under a linear mixed-effects model from the daily log\n 10<\/jats:sub>\n viral densities in standardised duplicate oropharyngeal swab eluates taken daily over 8 days [18 swabs per patient]), assessed in a modified intention-to-treat population (mITT). The safety population included all patients who received at least one dose of the allocated intervention. This ongoing adaptive platform trial was registered at ClinicalTrials.gov (NCT05041907) on 13\/09\/2021.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In the final analysis, the mITT population contained data from 114 patients randomised to favipiravir and 126 patients randomised concurrently to no study drug. Under the linear mixed-effects model fitted to all oropharyngeal viral density estimates in the first 8 days from randomisation (4,318 swabs), there was no difference in the rate of viral clearance between patients given favipiravir and patients receiving no study drug; a -1% (95% credible interval: -14 to 14%) difference. High dose favipiravir was well-tolerated.<\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n Favipiravir does not accelerate viral clearance in early symptomatic COVID-19. The viral clearance rate estimated\u00a0from quantitative measurements of oropharyngeal eluate viral densities assesses the antiviral efficacy of drugs in vivo with comparatively few studied\u00a0patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s12879-023-08835-3","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T06:02:18Z","timestamp":1705298538000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open-label, randomised, controlled, adaptive platform trial"],"prefix":"10.1186","volume":"24","author":[{"given":"Viravarn","family":"Luvira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H. K.","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Podjanee","family":"Jittamala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanaya","family":"Siripoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thundon","family":"Ngamprasertchai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro J.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maneerat","family":"Ekkapongpisit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cintia","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Callery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivani","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runch","family":"Tuntipaiboontana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varaporn","family":"Kruabkontho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thatsanun","family":"Ngernseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaruwan","family":"Tubprasert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Yazid","family":"Abdad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srisuda","family":"Keayarsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanassanan","family":"Madmanee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato S.","family":"Aguiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franciele M.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pongtorn","family":"Hanboonkunupakarn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borimas","family":"Hanboonkunupakarn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kittiyod","family":"Poovorawan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mallika","family":"Imwong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter R. J.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasin","family":"Chotivanich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kesinee","family":"Chotivanich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasithon","family":"Pukrittayakamee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjen M.","family":"Dondorp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas P. J.","family":"Day","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro M.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Watcharapong","family":"Piyaphanee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weerapong","family":"Phumratanaprapin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the PLATCOV Collaborative Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,15]]},"reference":[{"key":"8835_CR1","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1128\/AAC.46.4.977-981.2002","volume":"46","author":"Y Furuta","year":"2002","unstructured":"Furuta Y, Takahashi K, Fukuda Y, Kuno M, Kamiyama T, Kozaki K, et al. In vitro and in vivo activities of anti-influenza virus compound T-705. Antimicrob Agents Chemother. 2002;46:977\u201381.","journal-title":"Antimicrob Agents Chemother"},{"key":"8835_CR2","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.antiviral.2013.09.015","volume":"100","author":"Y Furuta","year":"2013","unstructured":"Furuta Y, Gowen BB, Takahashi K, Shiraki K, Smee DF, Barnard DL. Favipiravir (T-705), a novel viral RNA polymerase inhibitor. Antiviral Res. 2013;100:446\u201354.","journal-title":"Antiviral Res"},{"key":"8835_CR3","doi-asserted-by":"publisher","first-page":"e1001967","DOI":"10.1371\/journal.pmed.1001967","volume":"13","author":"D Sissoko","year":"2016","unstructured":"Sissoko D, Laouenan C, Folkesson E, M\u2019Lebing AB, Beavogui AH, Baize S, et al. Experimental treatment with favipiravir for ebola virus disease (the JIKI Trial): a historically controlled, single-arm proof-of-concept trial in Guinea. PLoS Med. 2016;13:e1001967.","journal-title":"PLoS Med"},{"key":"8835_CR4","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/s41422-020-0282-0","volume":"30","author":"M Wang","year":"2020","unstructured":"Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30:269\u201371.","journal-title":"Cell Res"},{"key":"8835_CR5","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cell.2020.05.034","volume":"182","author":"Q Wang","year":"2020","unstructured":"Wang Q, Wu J, Wang H, Gao Y, Liu Q, Mu A, et al. Structural basis for RNA replication by the SARS-CoV-2 polymerase. Cell. 2020;182:417\u201328.","journal-title":"Cell"},{"key":"8835_CR6","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1093\/jac\/dkaa171","volume":"75","author":"EA Coomes","year":"2020","unstructured":"Coomes EA, Haghbayan H. Favipiravir, an antiviral for COVID-19? J Antimicrob Chemother. 2020;75:2013\u20134.","journal-title":"J Antimicrob Chemother"},{"key":"8835_CR7","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1128\/AAC.01739-09","volume":"54","author":"K Sleeman","year":"2010","unstructured":"Sleeman K, Mishin VP, Deyde VM, Furuta Y, Klimov AI, Gubareva LV. In vitro antiviral activity of favipiravir (T-705) against drug-resistant influenza and 2009 A(H1N1) viruses. Antimicrob Agents Chemother. 2010;54:2517\u201324.","journal-title":"Antimicrob Agents Chemother"},{"key":"8835_CR8","doi-asserted-by":"publisher","first-page":"26955","DOI":"10.1073\/pnas.2014441117","volume":"117","author":"SJF Kaptein","year":"2020","unstructured":"Kaptein SJF, Jacobs S, Langendries L, Seldeslachts L, Ter Horst S, Liesenborghs L, et al. Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity. Proc Natl Acad Sci USA. 2020;117:26955\u201365.","journal-title":"Proc Natl Acad Sci USA"},{"key":"8835_CR9","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1038\/s41467-021-21992-w","volume":"12","author":"JS Driouich","year":"2021","unstructured":"Driouich JS, Cochin M, Lingas G, Moureau G, Touret F, Petit PR, et al. Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model. Nat Commun. 2021;12:1735.","journal-title":"Nat Commun"},{"key":"8835_CR10","doi-asserted-by":"publisher","first-page":"4551","DOI":"10.2147\/IJGM.S349241","volume":"15","author":"PK Reddy","year":"2022","unstructured":"Reddy PK, Patil S, Khobragade A, Balki A, Raj A, Kalikar M, et al. Evaluation of the safety and efficacy of favipiravir in adult Indian patients with mild-to-moderate COVID-19 in a real-world setting. Int J Gen Med. 2022;15:4551\u201363.","journal-title":"Int J Gen Med"},{"key":"8835_CR11","doi-asserted-by":"publisher","first-page":"e31681","DOI":"10.1097\/MD.0000000000031681","volume":"101","author":"T Sitasuwan","year":"2022","unstructured":"Sitasuwan T, Phisalprapa P, Srivanichakorn W, Washirasaksiri C, Auesomwang C, Tinmanee R, et al. Early antiviral and supervisory dexamethasone treatment improve clinical outcomes of nonsevere COVID-19 patients. Medicine (Baltimore). 2022;101:e31681.","journal-title":"Medicine (Baltimore)"},{"issue":"10","key":"8835_CR12","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/j.eng.2020.03.007","volume":"6","author":"Q Cai","year":"2020","unstructured":"Cai Q, Yang M, Liu D, Chen J, Shu D, Xia J, et al. Experimental treatment with favipiravir for COVID-19: an open-label control study. Engineering. 2020;6(10):1192\u20138.","journal-title":"Engineering"},{"key":"8835_CR13","unstructured":"Doi Y, Ishihara T, Banno S, Ando M, Kondo M. Favipiravir Observational Study. Favipiravir for symptomatic COVID-19: a nationwide observational cohort study. J Infect Chemother. 2022:S1341\u2013321X(22)00291\u20134."},{"issue":"3","key":"8835_CR14","doi-asserted-by":"publisher","first-page":"397","DOI":"10.55519\/JAMC-03-10305","volume":"34","author":"B Abdulrahman","year":"2022","unstructured":"Abdulrahman B, Mady A, Odat MA, Tayar AA, Rana MA, Alharthy A, et al. Favipiravir efficacy and safety for the treatment of severe coronavirus disease 2019: a retrospective study. J Ayub Med Coll Abbottabad. 2022;34(3):397\u2013402.","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"8835_CR15","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1080\/22221751.2022.2117092","volume":"11","author":"R Sirijatuphat","year":"2022","unstructured":"Sirijatuphat R, Manosuthi W, Niyomnaitham S, Owen A, Copeland KK, Charoenpong L, et al. Early treatment of Favipiravir in COVID-19 patients without pneumonia: a multicentre, open-labelled, randomized control study. Emerg Microbes Infect. 2022;11:2197\u2013206.","journal-title":"Emerg Microbes Infect"},{"key":"8835_CR16","doi-asserted-by":"publisher","first-page":"e01897","DOI":"10.1128\/AAC.01897-20","volume":"64","author":"Y Doi","year":"2020","unstructured":"Doi Y, Hibino M, Hase R, Yamamoto M, Kasamatsu Y, Hirose M, et al. Prospective, randomized, open-label trial of early versus late favipiravir therapy in hospitalized patients with COVID-19. Antimicrob Agents Chemother. 2020;64:e01897\u201320.","journal-title":"Antimicrob Agents Chemother."},{"key":"8835_CR17","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.ijid.2020.11.008","volume":"102","author":"F Khamis","year":"2021","unstructured":"Khamis F, Al Naabi H, Al Lawati A, Ambusaidi Z, Al Sharji M, Al Barwani U, et al. Randomized controlled open label trial on the use of favipiravir combined with inhaled interferon beta-1b in hospitalized patients with moderate to severe COVID-19 pneumonia. Int J Infect Dis. 2021;102:538\u201343.","journal-title":"Int J Infect Dis"},{"key":"8835_CR18","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1093\/cid\/ciaa1176","volume":"73","author":"AA Ivashchenko","year":"2021","unstructured":"Ivashchenko AA, Dmitriev KA, Vostokova NV, Azarova VN, Blinow AA, Egorova AN, et al. AVIFAVIR for treatment of patients with moderate coronavirus disease 2019 (COVID-19): interim results of a phase ii\/iii multicenter randomized clinical trial. Clin Infect Dis. 2021;73:531\u20134.","journal-title":"Clin Infect Dis"},{"key":"8835_CR19","doi-asserted-by":"crossref","unstructured":"Zhao H, Zhang C, Zhu Q, Chen X, Chen G, Sun W, et al. Favipiravir in the treatment of patients with SARS-CoV-2 RNA recurrent positive after discharge: a multicenter, open-label, randomized trial. Int Immunopharmacol. 2021;97:107702.","DOI":"10.1016\/j.intimp.2021.107702"},{"key":"8835_CR20","doi-asserted-by":"publisher","first-page":"107522","DOI":"10.1016\/j.intimp.2021.107522","volume":"95","author":"M Solaymani-Dodaran","year":"2021","unstructured":"Solaymani-Dodaran M, Ghanei M, Bagheri M, Qazvini A, Vahedi E, Hassan Saadat S, et al. Safety and efficacy of Favipiravir in moderate to severe SARS-CoV-2 pneumonia. Int Immunopharmacol. 2021;95:107522.","journal-title":"Int Immunopharmacol"},{"key":"8835_CR21","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ijid.2020.11.142","volume":"103","author":"ZF Udwadia","year":"2021","unstructured":"Udwadia ZF, Singh P, Barkate H, Patil S, Rangwala S, Pendse A, et al. Efficacy and safety of favipiravir, an oral RNA-dependent RNA polymerase inhibitor, in mild-to-moderate COVID-19: a randomized, comparative, open-label, multicenter, phase 3 clinical trial. Int J Infect Dis. 2021;103:62\u201371.","journal-title":"Int J Infect Dis"},{"issue":"1","key":"8835_CR22","doi-asserted-by":"publisher","first-page":"4925","DOI":"10.1038\/s41598-022-08794-w","volume":"12","author":"M Al Qahtani","year":"2022","unstructured":"Al Qahtani M, Kumar N, Aljawder D, Abdulrahman A, Mohamed MW, Alnashaba F, et al. Randomized controlled trial of favipiravir, hydroxychloroquine, and standard care in patients with mild\/moderate COVID-19 disease. Sci Rep. 2022;12(1):4925.","journal-title":"Sci Rep"},{"key":"8835_CR23","doi-asserted-by":"publisher","first-page":"3184","DOI":"10.1002\/jmv.27724","volume":"94","author":"M Hassaniazad","year":"2022","unstructured":"Hassaniazad M, Farshidi H, Gharibzadeh A, Bazram A, Khalili E, Noormandi A, Fathalipour M. Efficacy and safety of favipiravir plus interferon-beta versus lopinavir\/ritonavir plus interferon-beta in moderately ill patients with COVID-19: a randomized clinical trial. J Med Virol. 2022;94:3184\u201391.","journal-title":"J Med Virol"},{"key":"8835_CR24","doi-asserted-by":"publisher","first-page":"101703","DOI":"10.1016\/j.eclinm.2022.101703","volume":"54","author":"JH McMahon","year":"2022","unstructured":"McMahon JH, Lau JSY, Coldham A, Roney J, Hagenauer M, Price S, et al. Favipiravir in early symptomatic COVID-19, a randomised placebo-controlled trial. EClinicalMedicine. 2022;54:101703.","journal-title":"EClinicalMedicine"},{"key":"8835_CR25","doi-asserted-by":"publisher","first-page":"e1004120","DOI":"10.1371\/journal.pmed.1004120","volume":"19","author":"DM Lowe","year":"2022","unstructured":"Lowe DM, Brown LK, Chowdhury K, Davey S, Yee P, Ikeji F, et al. Favipiravir, lopinavir-ritonavir, or combination therapy (FLARE): a randomised, double-blind, 2 \u00d7 2 factorial placebo-controlled trial of early antiviral therapy in COVID-19. PLoS Med. 2022;19:e1004120.","journal-title":"PLoS Med"},{"key":"8835_CR26","first-page":"ciac712","volume":"6","author":"Y Golan","year":"2022","unstructured":"Golan Y, Campos JAS, Woolson R, Cilla D, Hanabergh R, Gonzales-Rojas Y, et al. Favipiravir in patients with early mild-to-moderate COVID-19: a randomized controlled trial. Clin Infect Dis. 2022;6:ciac712.","journal-title":"Clin Infect Dis."},{"key":"8835_CR27","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.cmi.2021.12.026","volume":"28","author":"M Bosaeed","year":"2022","unstructured":"Bosaeed M, Alharbi A, Mahmoud E, Alrehily S, Bahlaq M, Gaifer Z, et al. Efficacy of favipiravir in adults with mild COVID-19: a randomized, double-blind, multicentre, placebo-controlled clinical trial. Clin Microbiol Infect. 2022;28:602\u20138.","journal-title":"Clin Microbiol Infect"},{"key":"8835_CR28","doi-asserted-by":"publisher","first-page":"e432","DOI":"10.1093\/cid\/ciab962","volume":"75","author":"CH Chuah","year":"2022","unstructured":"Chuah CH, Chow TS, Hor CP, Cheng JT, Ker HB, Lee HG, et al. Efficacy of early treatment with favipiravir on disease progression among high-risk patients with coronavirus disease 2019 (COVID-19): a randomized open-label clinical trial. Clin Infect Dis. 2022;75:e432\u20139.","journal-title":"Clin Infect Dis"},{"key":"8835_CR29","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1093\/cid\/ciac312","volume":"75","author":"M Holubar","year":"2022","unstructured":"Holubar M, Subramanian A, Purington N, Hedlin H, Bunning B, Walter KS, et al. Favipiravir for treatment of outpatients with asymptomatic or uncomplicated coronavirus disease 2019: a double-blind, randomized, placebo-controlled, phase 2 trial. Clin Infect Dis. 2022;75:1883\u201392.","journal-title":"Clin Infect Dis"},{"key":"8835_CR30","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/em.22471","volume":"63","author":"MD Waters","year":"2022","unstructured":"Waters MD, Warren S, Hughes C, Lewis P, Zhang F. Human genetic risk of treatment with antiviral nucleoside analog drugs that induce lethal mutagenesis: the special case of molnupiravir. Environ Mol Mutagen. 2022;63:37\u201363.","journal-title":"Environ Mol Mutagen"},{"key":"8835_CR31","doi-asserted-by":"publisher","unstructured":"Schilling WHK, Jittamala P, Watson JA, Boyd S, Luvira V, Siripoon T, et al. Antiviral efficacy of molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial. Lancet Infect Dis. 2023:S1473-3099(23)00493-0. https:\/\/doi.org\/10.1016\/S1473-3099(23)00493-0. Epub ahead of print. Erratum in: Lancet Infect Dis. 2023;23(12):e511.","DOI":"10.1016\/S1473-3099(23)00493-0"},{"key":"8835_CR32","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1002\/cpt.1844","volume":"108","author":"YX Du","year":"2020","unstructured":"Du YX, Chen XP. Favipiravir: pharmacokinetics and concerns about clinical trials for 2019-nCoV infection. Clin Pharmacol Ther. 2020;108:242\u20137.","journal-title":"Clin Pharmacol Ther"},{"key":"8835_CR33","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1056\/NEJMoa2116044","volume":"386","author":"A Jayk Bernal","year":"2022","unstructured":"Jayk Bernal A, Gomes da Silva MM, Musungaie DB, Kovalchuk E, Gonzalez A, Delos Reyes V, et al. Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients. N Engl J Med. 2022;386:509\u201320.","journal-title":"N Engl J Med"},{"key":"8835_CR34","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1056\/NEJMoa2118542","volume":"386","author":"J Hammond","year":"2022","unstructured":"Hammond J, Leister-Tebbe H, Gardner A, Abreu P, Bao W, Wisemandle W, et al. Oral nirmatrelvir for high-risk, nonhospitalized adults with Covid-19. N Engl J Med. 2022;386:1397\u2013408.","journal-title":"N Engl J Med"},{"key":"8835_CR35","doi-asserted-by":"publisher","first-page":"e0005389","DOI":"10.1371\/journal.pntd.0005389","volume":"11","author":"TH Nguyen","year":"2017","unstructured":"Nguyen TH, Guedj J, Anglaret X, Laou\u00e9nan C, Madelain V, Taburet AM, et al. Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals concentrations lower than targeted. PLoS Negl Trop Dis. 2017;11:e0005389.","journal-title":"PLoS Negl Trop Dis"},{"key":"8835_CR36","doi-asserted-by":"publisher","unstructured":"Schilling WHK, Jittamala P, Watson JA, Ekkapongpisit M, Siripoon T, Ngamprasertchai T, et al. Pharmacometrics of high-dose ivermectin in early COVID-19 from an open label, randomized, controlled adaptive platform trial (PLATCOV). Elife. 2023;12:e83201. https:\/\/doi.org\/10.7554\/eLife.83201.","DOI":"10.7554\/eLife.83201"},{"key":"8835_CR37","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1056\/NEJMoa2115869","volume":"386","author":"G Reis","year":"2022","unstructured":"Reis G, Silva EASM, Silva DCM, Thabane L, Milagres AC, Ferreira TS, et al. Effect of early treatment with ivermectin among patients with Covid-19. N Engl J Med. 2022;386:1721\u201331.","journal-title":"N Engl J Med"},{"issue":"10","key":"8835_CR38","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1093\/infdis\/jiad275","volume":"228","author":"P Jittamala","year":"2023","unstructured":"Jittamala P, Schilling WHK, Watson JA, Luvira V, Siripoon T, Ngamprasertchai T, et al. Clinical antiviral efficacy of remdesivir in COVID-19: an open label, randomized, controlled adaptive platform trial (PLATCOV). J Infect Dis. 2023;228(10):1318\u201325. https:\/\/doi.org\/10.1093\/infdis\/jiad275.","journal-title":"J Infect Dis"},{"key":"8835_CR39","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1056\/NEJMoa2116846","volume":"386","author":"RL Gottlieb","year":"2022","unstructured":"Gottlieb RL, Vaca CE, Paredes R, Mera J, Webb BJ, Perez G, et al. Early remdesivir to prevent progression to severe Covid-19 in outpatients. N Engl J Med. 2022;386:305\u201315.","journal-title":"N Engl J Med"},{"key":"8835_CR40","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1056\/NEJMoa2035002","volume":"384","author":"DM Weinreich","year":"2021","unstructured":"Weinreich DM, Sivapalasingam S, Norton T, Ali S, Gao H, Bhore R, et al. REGN-COV2, a neutralizing antibody cocktail, in outpatients with COVID-19. N Engl J Med. 2021;384:238\u201351.","journal-title":"N Engl J Med"},{"key":"8835_CR41","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1056\/NEJMoa2109682","volume":"385","author":"MP O'Brien","year":"2021","unstructured":"O\u2019Brien MP, Forleo-Neto E, Musser BJ, Isa F, Chan KC, Sarkar N, et al. Covid-19 phase 3 prevention trial team. Subcutaneous REGEN-COV antibody combination to prevent Covid-19. N Engl J Med. 2021;385:1184\u201395.","journal-title":"N Engl J Med."},{"key":"8835_CR42","doi-asserted-by":"publisher","first-page":"eabl7430","DOI":"10.1126\/scitranslmed.abl7430","volume":"14","author":"WA Fischer 2nd","year":"2022","unstructured":"Fischer WA 2nd, Eron JJ Jr, Holman W, Cohen MS, Fang L, Szewczyk LJ, et al. A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus. Sci Transl Med. 2022;14:eabl7430.","journal-title":"Sci Transl Med"},{"key":"8835_CR43","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0140-6736(22)02597-1","volume":"401","author":"CC Butler","year":"2023","unstructured":"Butler CC, Hobbs DR, Gbinigie OA, Rahman NM, Hayward G, Richards DB, et al. Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial. Lancet. 2023;401:281\u201393.","journal-title":"Lancet"},{"key":"8835_CR44","doi-asserted-by":"publisher","first-page":"e0019222","DOI":"10.1128\/aac.00192-22","volume":"66","author":"JA Watson","year":"2022","unstructured":"Watson JA, Kissler SM, Day NPJ, Grad YH, White NJ. Characterizing SARS-CoV-2 viral clearance kinetics to improve the design of antiviral pharmacometric studies. Antimicrob Agents Chemother. 2022;66:e0019222.","journal-title":"Antimicrob Agents Chemother"}],"container-title":["BMC Infectious Diseases"],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-023-08835-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-023-08835-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-023-08835-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T18:01:47Z","timestamp":1705341707000},"score":9.763665,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-023-08835-3"}},"issued":{"date-parts":[[2024,1,15]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["8835"],"URL":"https:\/\/doi.org\/10.1186\/s12879-023-08835-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2675703\/v1","asserted-by":"object"}]},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"published":{"date-parts":[[2024,1,15]]},"assertion":[{"value":"10 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All patients provided fully informed written consent. The trial was approved by local and national research ethics boards in Thailand (Faculty of Tropical Medicine Ethics Committee, Mahidol University, FTMEC Ref: TMEC 21\u2013058) and the Central Research Ethics Committee (CREC, Bangkok, Thailand, CREC Ref: CREC048\/64BP-MED34), in Brazil by the Research Ethics Committee of the Universidade Federal de Minas Gerais (COEP-UFMG, Minas Gerais, Brazil, COEP-UFMG) and National Research Ethics Commission- (CONEP, Brazil, COEP-UFMG and CONEP Ref: CAAE:51593421.1.0000.5149), and by the Oxford University Tropical Research Ethics Committee (OxTREC, Oxford, UK, OxTREC Ref: 24\u201321). All methods were performed in accordance with the relevant guidelines and regulations (e.g. Declaration of Helsinki).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"89"},{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:03:17Z","timestamp":1772136197206,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["106680\/Z\/14\/Z"],"award-info":[{"award-number":["106680\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"Abstract<\/jats:title>\n Vietnam has high rates of antibiotic use and resistance. Measuring resistance in commensal bacteria could provide an objective indicator for evaluating the impact of interventions to reduce antibiotic use and resistance. This study aimed to evaluate the feasibility, acceptability, and bacterial recovery for different sampling strategies. We conducted a cross-sectional mixed methods study in a rural community in Ha Nam Province, northern Vietnam, and collected structured interviews, samples, and in-depth interviews from households. Out of 389 households invited, 324 participated (83%), representing 1502 individuals. Samples were collected from these individuals (1498 stool, 1002 self-administered nasal swabs, and 496 HW-administered nasopharyngeal swabs). Pneumococci were recovered from 11.1% (128\/1149) of the total population and 26.2% (48\/183) of those under 5-years. Recovery was higher for health-worker (HW)-administered swabs (13.7%, 48\/350) than self-administered swabs (10.0%, 80\/799) (OR 2.06, 95% CI 1.07\u20133.96).\u00a0Cost\u00a0per swab was\u00a0cheaper for self-administered ($7.26) than HW-administered\u00a0($8.63) swabs, but the overall\u00a0cost for 100 positive samples was higher ($7260 and\u00a0$6300 respectively).\ufeff Qualitative interviews revealed that HW-administered nasopharyngeal swabs took longer to collect, caused more discomfort, and were more difficult to take from children. Factors affecting participation included sense of contribution, perceived trade-offs between benefits and effort, and peer influence. Reluctance was related to stool sampling and negative perceptions of research. This study provides important evidence for planning community-based carriage studies, including cost, logistics, and acceptability. Self-administered swabs had lower recovery, and though cheaper and quicker, this would translate to higher costs for large population-based studies. Recovery might be improved by swab-type, transport medium, and better cold-chain to lab.<\/jats:p>","DOI":"10.1038\/s41598-022-27084-z","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T06:02:48Z","timestamp":1672293768000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Feasibility, acceptability, and bacterial recovery for community-based sample collection to estimate antibiotic resistance in commensal gut and upper respiratory tract bacteria"],"prefix":"10.1038","volume":"12","author":[{"given":"Hoang Huy","family":"Tran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hien Anh Thi","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huyen Bang","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bich Ngoc Thi","family":"Vu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu Cam Thi","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costanza","family":"Tacoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thao Phuong","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tung Son","family":"Trinh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thien Huong Ngoc","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behzad","family":"Nadjm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieu H\u01b0\u01a1ng Thi","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quynh Dieu","family":"Pham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Th\u01b0\u01a1ng Hong Thi","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trang Thu","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thai Duy","family":"Pham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kesteman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duc Anh","family":"Dang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien Dac","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Rogier","family":"van Doorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Lewycka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"issue":"1","key":"27084_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2458-13-1158","volume":"13","author":"K van Nguyen","year":"2013","unstructured":"van Nguyen, K. et al. Antibiotic use and resistance in emerging economies: a situation analysis for Viet Nam. BMC Public Health 13(1), 1\u201310 (2013).","journal-title":"BMC Public Health"},{"key":"27084_CR2","first-page":"84","volume":"7","author":"AQ Chua","year":"2021","unstructured":"Chua, A. Q., Verma, M., Hsu, L. Y. & Legido-Quigley, H. An analysis of national action plans on antimicrobial resistance in Southeast Asia using a governance framework approach. Lancet Reg Health West Pac. 7, 84 (2021).","journal-title":"Lancet Reg Health West Pac."},{"key":"27084_CR3","unstructured":"Ministry of Health. National Action Plan on Combatting Drug Resistance in the period from 2013 to 2020. Hanoi (2013)."},{"key":"27084_CR4","doi-asserted-by":"crossref","unstructured":"Aabenhus, R., Jensen, J. U. S., J\u00f8rgensen, K. J., Hr\u00f3bjartsson, A., Bjerrum. L. Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care. Cochrane Database Syst. Rev. 2014(11) (2014).","DOI":"10.1002\/14651858.CD010130.pub2"},{"issue":"8","key":"27084_CR5","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.1177\/0300060518782519","volume":"46","author":"MS McDonagh","year":"2018","unstructured":"McDonagh, M. S. et al. Interventions to reduce inappropriate prescribing of antibiotics for acute respiratory tract infections: Summary and update of a systematic review. J. Int. Med. Res. 46(8), 3337\u20133357 (2018).","journal-title":"J. Int. Med. Res."},{"key":"27084_CR6","doi-asserted-by":"crossref","unstructured":"Tonkin-Crine, S. K. G., Tan, P. S., van Hecke, O., Wang, K., Roberts, N. W., Mccullough, A. et al. Clinician-targeted interventions to influence antibiotic prescribing behaviour for acute respiratory infections in primary care: an overview of systematic reviews. Cochrane Datab. Syst. Rev. 9(9) (2017).","DOI":"10.1002\/14651858.CD012252.pub2"},{"issue":"12","key":"27084_CR7","doi-asserted-by":"publisher","first-page":"e1258","DOI":"10.1016\/S2214-109X(17)30383-2","volume":"5","author":"X Wei","year":"2017","unstructured":"Wei, X. et al. Effect of a training and educational intervention for physicians and caregivers on antibiotic prescribing for upper respiratory tract infections in children at primary care facilities in rural China: A cluster-randomised controlled trial. Lancet Glob. Health. 5(12), e1258\u2013e1267 (2017).","journal-title":"Lancet Glob. Health."},{"issue":"10","key":"27084_CR8","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1046\/j.1365-3156.2000.00630.x","volume":"5","author":"M Larsson","year":"2000","unstructured":"Larsson, M. et al. Antibiotic medication and bacterial resistance to antibiotics: A survey of children in a Vietnamese community. Trop. Med. Int. Health. 5(10), 711\u2013721 (2000).","journal-title":"Trop. Med. Int. Health."},{"issue":"1","key":"27084_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2050-6511-15-6","volume":"15","author":"DTT Nga","year":"2014","unstructured":"Nga, D. T. T. et al. Antibiotic sales in rural and urban pharmacies in northern Vietnam: An observational study. BMC Pharmacol. Toxicol. 15(1), 1\u201310 (2014).","journal-title":"BMC Pharmacol. Toxicol."},{"issue":"5","key":"27084_CR10","doi-asserted-by":"publisher","first-page":"e610","DOI":"10.1016\/S2214-109X(21)00024-3","volume":"9","author":"NTT Do","year":"2021","unstructured":"Do, N. T. T. et al. Community-based antibiotic access and use in six low-income and middle-income countries: A mixed-method approach. Lancet Glob. Health. 9(5), e610\u2013e619 (2021).","journal-title":"Lancet Glob. Health."},{"issue":"7756","key":"27084_CR11","first-page":"1120","volume":"340","author":"C Costelloe","year":"2010","unstructured":"Costelloe, C., Metcalfe, C., Lovering, A., Mant, D. & Hay, A. D. Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: Systematic review and meta-analysis. BMJ 340(7756), 1120 (2010).","journal-title":"BMJ"},{"issue":"1","key":"27084_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2334-14-13","volume":"14","author":"BG Bell","year":"2014","unstructured":"Bell, B. G., Schellevis, F., Stobberingh, E., Goossens, H. & Pringle, M. A systematic review and meta-analysis of the effects of antibiotic consumption on antibiotic resistance. BMC Infect. Dis. 14(1), 1\u201325 (2014).","journal-title":"BMC Infect. Dis."},{"issue":"9459","key":"27084_CR13","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/S0140-6736(05)17907-0","volume":"365","author":"H Goossens","year":"2005","unstructured":"Goossens, H., Ferech, M. & vander Stichele R, Elseviers M.,. Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. Lancet 365(9459), 579\u2013587 (2005).","journal-title":"Lancet"},{"issue":"7","key":"27084_CR14","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1086\/432721","volume":"41","author":"D Guillemot","year":"2005","unstructured":"Guillemot, D. et al. Reduction of antibiotic use in the community reduces the rate of colonization with penicillin G-nonsusceptible Streptococcus pneumoniae. Clin. Infect. Dis. 41(7), 930\u2013938 (2005).","journal-title":"Clin. Infect. Dis."},{"issue":"9","key":"27084_CR15","doi-asserted-by":"publisher","first-page":"e450","DOI":"10.1016\/S2666-5247(21)00064-1","volume":"2","author":"K Andrejko","year":"2021","unstructured":"Andrejko, K., Ratnasiri, B., Hausdorff, W. P., Laxminarayan, R. & Lewnard, J. A. Antimicrobial resistance in paediatric Streptococcus pneumoniae isolates amid global implementation of pneumococcal conjugate vaccines: A systematic review and meta-regression analysis. Lancet Microb. 2(9), e450 (2021).","journal-title":"Lancet Microb."},{"issue":"8","key":"27084_CR16","doi-asserted-by":"publisher","first-page":"e103293","DOI":"10.1371\/journal.pone.0103293","volume":"9","author":"RA Adegbola","year":"2014","unstructured":"Adegbola, R. A. et al. Carriage of Streptococcus pneumoniae and other respiratory bacterial pathogens in low and lower-middle income countries: A systematic review and meta-analysis. PLoS ONE 9(8), e103293 (2014).","journal-title":"PLoS ONE"},{"key":"27084_CR17","unstructured":"Talarico, C. A. Epidemiologic characteristics of colonizing streptococcus pneumoniae in Vietnam and implications for population vaccination [PhD]. The University of Michigan (2009)."},{"issue":"6","key":"27084_CR18","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1111\/apa.15795","volume":"110","author":"M Larsson","year":"2021","unstructured":"Larsson, M. et al. Multi-drug resistance in Streptococcus pneumoniae among children in rural Vietnam more than doubled from 1999 to 2014. Acta Paediatr. 110(6), 1916\u20131923. https:\/\/doi.org\/10.1111\/apa.15795 (2021).","journal-title":"Acta Paediatr."},{"issue":"1","key":"27084_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2334-10-85","volume":"10","author":"NQ Hoa","year":"2010","unstructured":"Hoa, N. Q. et al. Decreased Streptococcus pneumoniae susceptibility to oral antibiotics among children in rural Vietnam: A community study. BMC Infect. Dis. 10(1), 1\u201311 (2010).","journal-title":"BMC Infect. Dis."},{"issue":"3","key":"27084_CR20","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1128\/AAC.44.3.484-488.2000","volume":"44","author":"CM Parry","year":"2000","unstructured":"Parry, C. M. et al. Nasal carriage in Vietnamese children of Streptococcus pneumoniae resistant to multiple antimicrobial agents. Antimicrob. Agents Chemother. 44(3), 484\u2013488 (2000).","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"27084_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12879-019-3861-2","volume":"19","author":"HAT Nguyen","year":"2019","unstructured":"Nguyen, H. A. T. et al. An alarmingly high nasal carriage rate of Streptococcus pneumoniae serotype 19F non-susceptible to multiple beta-lactam antimicrobials among Vietnamese children. BMC Infect. Dis. 19(1), 1\u201310. https:\/\/doi.org\/10.1186\/s12879-019-3861-2 (2019).","journal-title":"BMC Infect. Dis."},{"issue":"5","key":"27084_CR22","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.trstmh.2006.08.010","volume":"101","author":"C Schultsz","year":"2007","unstructured":"Schultsz, C. et al. Changes in the nasal carriage of drug-resistant Streptococcus pneumoniae in urban and rural Vietnamese schoolchildren. Trans. R. Soc. Trop. Med. Hyg. 101(5), 484\u2013492 (2007).","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"10","key":"27084_CR23","doi-asserted-by":"publisher","first-page":"e110777","DOI":"10.1371\/journal.pone.0110777","volume":"9","author":"BG Dhoubhadel","year":"2014","unstructured":"Dhoubhadel, B. G. et al. Bacterial load of pneumococcal serotypes correlates with their prevalence and multiple serotypes is associated with acute respiratory infections among children less than 5 years of age. PLoS ONE 9(10), e110777 (2014).","journal-title":"PLoS ONE"},{"issue":"10","key":"27084_CR24","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1086\/320165","volume":"32","author":"NY Lee","year":"2001","unstructured":"Lee, N. Y. et al. Carriage of antibiotic-resistant pneumococci among Asian children: A multinational surveillance by the Asian Network for Surveillance of Resistant Pathogens (ANSORP). Clin. Infect. Dis. 32(10), 1463\u20131469 (2001).","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"27084_CR25","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.vaccine.2013.08.062","volume":"32","author":"C Satzke","year":"2013","unstructured":"Satzke, C. et al. Standard method for detecting upper respiratory carriage of Streptococcus pneumoniae: updated recommendations from the World Health Organization Pneumococcal Carriage Working Group. Vaccine. 32(1), 165\u2013179 (2013).","journal-title":"Vaccine."},{"issue":"6","key":"27084_CR26","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1128\/JCM.00048-08","volume":"46","author":"AJ Leach","year":"2008","unstructured":"Leach, A. J., Stubbs, E., Hare, K., Beissbarth, J. & Morris, P. S. Comparison of nasal swabs with nose blowing for community-based pneumococcal surveillance of healthy children. J. Clin. Microbiol. 46(6), 2081\u20132082 (2008).","journal-title":"J. Clin. Microbiol."},{"issue":"5","key":"27084_CR27","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1128\/jcm.35.5.1077-1079.1997","volume":"35","author":"S Rapola","year":"1997","unstructured":"Rapola, S., Salo, E., Kiiski, P., Leinonen, M. & Takala, A. K. Comparison of four different sampling methods for detecting pharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae in children. J. Clin. Microbiol. 35(5), 1077\u20131079 (1997).","journal-title":"J. Clin. Microbiol."},{"issue":"1","key":"27084_CR28","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1128\/JCM.01131-06","volume":"45","author":"KS Carville","year":"2007","unstructured":"Carville, K. S., Bowman, J. M., Lehmann, D. & Riley, T. V. Comparison between nasal swabs and nasopharyngeal aspirates for, and effect of time in transit on, isolation of Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, and Moraxella catarrhalis. J. Clin. Microbiol. 45(1), 244\u2013245 (2007).","journal-title":"J. Clin. Microbiol."},{"key":"27084_CR29","doi-asserted-by":"publisher","first-page":"5341","DOI":"10.1136\/bmjopen-2014-005341","volume":"4","author":"AL Coughtrie","year":"2014","unstructured":"Coughtrie, A. L. et al. Evaluation of swabbing methods for estimating the prevalence of bacterial carriage in the upper respiratory tract: A cross sectional study. BMJ Open 4, 5341 (2014).","journal-title":"BMJ Open"},{"issue":"1","key":"27084_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2334-12-92","volume":"12","author":"OJ Dyar","year":"2012","unstructured":"Dyar, O. J. et al. High prevalence of antibiotic resistance in commensal Escherichia coli among children in rural Vietnam. BMC Infect. Dis. 12(1), 1\u20138. https:\/\/doi.org\/10.1186\/1471-2334-12-92 (2012).","journal-title":"BMC Infect. Dis."},{"key":"27084_CR31","unstructured":"WHO RO for the WP. Human resources for health country profiles: Viet Nam [Internet]. Available from: https:\/\/apps.who.int\/iris\/handle\/10665\/259990 (2016)."},{"key":"27084_CR32","doi-asserted-by":"publisher","DOI":"10.1128\/9781555816728.ch20","author":"B Spellerberg","year":"2011","unstructured":"Spellerberg, B. & Brandt, C. Streptococcus. Man. Clin. Microbiol. https:\/\/doi.org\/10.1128\/9781555816728.ch20 (2011).","journal-title":"Man. Clin. Microbiol."},{"issue":"4","key":"27084_CR33","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/j.1469-0691.2006.01667.x","volume":"13","author":"G Wilson","year":"2007","unstructured":"Wilson, G. & Mccabe, D. The use of antibiotic-containing agars for the isolation of extended-spectrum \u03b2-lactamase-producing organisms in intensive care units. Clin. Microbiol. Infect. 13(4), 451\u2013453. https:\/\/doi.org\/10.1111\/j.1469-0691.2006.01667.x (2007).","journal-title":"Clin. Microbiol. Infect."},{"issue":"1","key":"27084_CR34","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1177\/1525822x05279903","volume":"18","author":"G Guest","year":"2006","unstructured":"Guest, G., Bunce, A. & Johnson, L. How many interviews are enough? An experiment with data saturation and variability. Field Methods 18(1), 59\u201382. https:\/\/doi.org\/10.1177\/1525822x05279903 (2006).","journal-title":"Field Methods"},{"issue":"2","key":"27084_CR35","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1177\/1098214005283748","volume":"27","author":"DR Thomas","year":"2006","unstructured":"Thomas, D. R. A general inductive approach for analyzing qualitative evaluation data. Am. J. Eval. 27(2), 237\u2013246. https:\/\/doi.org\/10.1177\/1098214005283748 (2006).","journal-title":"Am. J. Eval."},{"key":"27084_CR36","unstructured":"Copan. TransystemTM: Traditional Bacteriology Transport Swabs For Collection and Transport of Aerobic and Anaerobic Bacteria [Internet]. Available from: http:\/\/www.copanusa.com\/products\/collection-transport\/m40-transystem\/."},{"issue":"5","key":"27084_CR37","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.jen.2021.04.006","volume":"47","author":"TT Nguyen","year":"2021","unstructured":"Nguyen, T. T., Zeger, W. G., Wadman, M. C. & Barksdale, A. N. Accuracy and acceptance of a self-collection model for respiratory tract infection diagnostics: A concise clinical literature review. J. Emerg. Nurs. 47(5), 798\u2013806 (2021).","journal-title":"J. Emerg. Nurs."},{"issue":"118","key":"27084_CR38","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jcv.2019.07.010","volume":"1","author":"CP Seaman","year":"2019","unstructured":"Seaman, C. P., Tran, L. T. T., Cowling, B. J. & Sullivan, S. G. Self-collected compared with professional-collected swabbing in the diagnosis of influenza in symptomatic individuals: A meta-analysis and assessment of validity. J. Clin. Virol. 1(118), 28\u201335 (2019).","journal-title":"J. Clin. Virol."},{"issue":"12","key":"27084_CR39","doi-asserted-by":"publisher","first-page":"e0244417","DOI":"10.1371\/journal.pone.0244417","volume":"15","author":"SY Tan","year":"2020","unstructured":"Tan, S. Y. et al. The accuracy of healthcare worker versus self collected (2-in-1) Oropharyngeal and Bilateral Mid-Turbinate (OPMT) swabs and saliva samples for SARS-CoV-2. PLoS ONE 15(12), e0244417. https:\/\/doi.org\/10.1371\/journal.pone.0244417 (2020).","journal-title":"PLoS ONE"},{"key":"27084_CR40","doi-asserted-by":"crossref","unstructured":"Vuichard, D., Singh, P., Luinstra, K., Newton, J., Loeb, M., Smieja, M. Agreement between nasal midturbinate and nasopharyngeal swab to detect streptococcus pneumoniae by polymerase chain reaction in children and adults. Open Forum Infect Dis. 3(suppl_1) (2016).","DOI":"10.1093\/ofid\/ofw172.63"},{"issue":"6","key":"27084_CR41","doi-asserted-by":"publisher","first-page":"e68097","DOI":"10.1371\/journal.pone.0068097","volume":"8","author":"FS Dube","year":"2013","unstructured":"Dube, F. S., Kaba, M., Whittaker, E., Zar, H. J. & Nicol, M. P. Detection of Streptococcus pneumoniae from Different Types of Nasopharyngeal Swabs in Children. PLoS ONE 8(6), e68097 (2013).","journal-title":"PLoS ONE"},{"issue":"4","key":"27084_CR42","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/01.inf.0000257425.24492.11","volume":"26","author":"SM Granat","year":"2007","unstructured":"Granat, S. M. et al. Longitudinal study on pneumococcal carriage during the first year of life in Bangladesh. Pediatr. Infect Dis. J. 26(4), 319\u2013324 (2007).","journal-title":"Pediatr. Infect Dis. J."},{"issue":"1","key":"27084_CR43","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1097\/INF.0b013e31814da70c","volume":"27","author":"O Abdullahi","year":"2008","unstructured":"Abdullahi, O., Nyiro, J., Lewa, P., Slack, M. & Scott, J. A. G. The descriptive epidemiology of Streptococcus pneumoniae and Haemophilus influenzae nasopharyngeal carriage in children and adults in Kilifi district, Kenya. Pediatr. Infect Dis. J. 27(1), 59\u201364 (2008).","journal-title":"Pediatr. Infect Dis. J."},{"issue":"4","key":"27084_CR44","doi-asserted-by":"publisher","first-page":"e35061","DOI":"10.1371\/journal.pone.0035061","volume":"7","author":"G Regev-Yochay","year":"2012","unstructured":"Regev-Yochay, G. et al. Streptococcus pneumoniae carriage in the Gaza strip. PLoS ONE 7(4), e35061 (2012).","journal-title":"PLoS ONE"},{"key":"27084_CR45","unstructured":"World Bank Group. Climate Change Knowledge Portal [Internet]. [cited 2022 Mar 29]. Available from: https:\/\/climateknowledgeportal.worldbank.org\/country\/vietnam\/climate-data-historical."}],"container-title":["Scientific Reports"],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-27084-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-27084-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-27084-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T04:02:41Z","timestamp":1672545761000},"score":9.759443,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-022-27084-z"}},"issued":{"date-parts":[[2022,12,29]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["27084"],"URL":"https:\/\/doi.org\/10.1038\/s41598-022-27084-z","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-1663712\/v2","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-1663712\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"published":{"date-parts":[[2022,12,29]]},"assertion":[{"value":"7 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"22512"},{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:34Z","timestamp":1772168974317,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.73900.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000}},{"DOI":"10.12688\/f1000research.73900.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000}}],"reference-count":32,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["214185\/Z\/18\/Z"],"award-info":[{"award-number":["214185\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["074833\/Z\/04\/Z"],"award-info":[{"award-number":["074833\/Z\/04\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["103994\/Z\/14\/Z"],"award-info":[{"award-number":["103994\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome","award":["20517\/Z\/16\/Z"],"award-info":[{"award-number":["20517\/Z\/16\/Z"]}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"\n Background<\/ns3:bold>\n <\/ns3:p>\n The long-term impact of elevated blood pressure on mortality outcomes has been recently revisited due to proposed changes in cut-offs for hypertension. This study aimed at assessing the association between high blood pressure levels and 10-year mortality using the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) and the American College of Cardiology and the American Heart Association (ACC\/AHA) 2017 blood pressure guidelines.<\/ns3:p>\n \n Methods<\/ns3:bold>\n <\/ns3:p>\n Data of the PERU MIGRANT Study, a prospective ongoing cohort, was used. The outcome of interest was 10-year all-cause mortality, and exposures were blood pressure categories according to the JNC-7 and ACC\/AHA 2017 guidelines. Log-rank test, Kaplan-Meier and Cox regression models were used to assess the associations of interest controlling for confounders. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated.<\/ns3:p>\n \n Results<\/ns3:bold>\n <\/ns3:p>\n A total of 976 records, mean age of 60.4 (SD: 11.4), 513 (52.6%) women, were analyzed. Hypertension prevalence at baseline almost doubled from 16.0% (95% CI 13.7%\u201318.4%) to 31.3% (95% CI 28.4%\u201334.3%), using the JNC-7 and ACC\/AHA 2017 definitions, respectively. Sixty-three (6.4%) participants died during the 10-year follow-up, equating to a mortality rate of 3.6 (95% CI 2.4\u20134.7) per 1000 person-years. Using JNC-7, and compared to those with normal blood pressure, those with pre-hypertension and hypertension had 2-fold and 3.5-fold increased risk of death, respectively. Similar mortality effect sizes were estimated using ACC\/AHA 2017 for stage 1 and stage 2 hypertension.<\/ns3:p>\n \n Conclusions<\/ns3:bold>\n <\/ns3:p>\n Blood pressure levels under two different definitions increased the risk of 10-year all-cause mortality. Hypertension prevalence doubled using ACC\/AHA 2017 compared to JNC-7. The choice of blood pressure cut-offs to classify hypertension categories need to be balanced against the patients benefit and the capacities of the health system to adequately handle a large proportion of new patients.<\/ns3:p>","DOI":"10.12688\/f1000research.73900.3","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T04:45:08Z","timestamp":1681274708000},"page":"1134","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Blood pressure and 10-year all-cause mortality: Findings from the PERU MIGRANT Study"],"prefix":"10.12688","volume":"10","author":[{"given":"Aida","family":"Hidalgo-Benites","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Senosain-Leon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo M.","family":"Carrillo-Larco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ruiz-Alejos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Gilman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam","family":"Smeeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4738-5468","authenticated-orcid":false,"given":"J. Jaime","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-1376","authenticated-orcid":false,"given":"Antonio","family":"Bernab\u00e9-Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,4,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1603-1658","DOI":"10.1016\/S0140-6736(16)31460-X","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.","volume":"388","year":"2016","journal-title":"Lancet."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2224-2260","DOI":"10.1016\/S0140-6736(12)61766-8","article-title":"A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010.","volume":"380","author":"S Lim","year":"2012","journal-title":"Lancet."},{"key":"ref4","first-page":"37-55","article-title":"Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants.","volume":"389","year":"2017","journal-title":"Lancet."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1206-1252","DOI":"10.1161\/01.HYP.0000107251.49515.c2","article-title":"Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.","volume":"42","author":"A Chobanian","year":"2003","journal-title":"Hypertension."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e426-e483","DOI":"10.1161\/CIR.0000000000000597","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines.","volume":"138","author":"P Whelton","year":"2018","journal-title":"Circulation."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"956-960","DOI":"10.1016\/j.amjmed.2017.12.049","article-title":"Baseline Blood Pressure, the 2017 ACC\/AHA High Blood Pressure Guidelines, and Long-Term Cardiovascular Risk in SPRINT.","volume":"131","author":"M Vaduganathan","year":"2018","journal-title":"Am. J. Med."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"399-410","DOI":"10.23736\/S0026-4725.19.04965-X","article-title":"Implications of the new 2017 American College of Cardiology\/American Aeart Association Guidelines for Hypertension.","volume":"67","author":"W Aronow","year":"2019","journal-title":"Minerva Cardioangiol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"6382","DOI":"10.1038\/s41598-019-42809-3","article-title":"Status of Hypertension in Tehran: Potential impact of the ACC\/AHA 2017 and JNC7 Guidelines, 2012\u20132015.","volume":"9","author":"S Asgari","year":"2019","journal-title":"Sci. Rep."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"109-118","DOI":"10.1161\/CIRCULATIONAHA.117.032582","article-title":"Potential US Population Impact of the 2017 ACC\/AHA High Blood Pressure Guideline.","volume":"137","author":"P Muntner","year":"2018","journal-title":"Circulation."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s11906-019-0906-2","article-title":"Impact of the 2017 American College of Cardiology\/American Heart Association Blood Pressure Guidelines on the Next Blood Pressure Guidelines in Asia.","volume":"21","author":"N Nakagawa","year":"2019","journal-title":"Curr. Hypertens. Rep."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"545-556","DOI":"10.4067\/S0034-98872019000500545","article-title":"Changes in the prevalence of hypertension in Peru using the new guideline of the American College of Cardiology.","volume":"147","author":"A Hernandez-Vasquez","year":"2019","journal-title":"Rev. Med. Chil."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"668-670","DOI":"10.1177\/2047487318799489","article-title":"New 2017 ACC\/AHA hypertension guideline: Implications for a Latin American country like Peru.","volume":"26","author":"A Hern\u00e1ndez-V\u00e1squez","year":"2019","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1256-1264","DOI":"10.1161\/HYPERTENSIONAHA.106.083592","article-title":"Predictive utility of pulse pressure and other blood pressure measures for cardiovascular outcomes.","volume":"49","author":"W Mosley","year":"2007","journal-title":"Hypertension."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"345-354","DOI":"10.1177\/2047487319862066","article-title":"Associations of blood pressure categories defined by 2017 ACC\/AHA guidelines with mortality in China: Pooled results from three prospective cohorts.","volume":"27","author":"N Liu","year":"2020","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"678-685","DOI":"10.1111\/jch.12375","article-title":"Brachial pulse pressure and cardiovascular or all-cause mortality in the general population: a meta-analysis of prospective observational studies.","volume":"16","author":"L Zhao","year":"2014","journal-title":"J. Clin. Hypertens. (Greenwich)."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"775-781","DOI":"10.1001\/jamacardio.2017.1421","article-title":"Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Network Meta-analysis.","volume":"2","author":"J Bundy","year":"2017","journal-title":"JAMA Cardiol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e035190","DOI":"10.1136\/bmjopen-2019-035190","article-title":"Association between blood pressure levels and cardiovascular deaths: a 20-year follow-up study in rural China.","volume":"10","author":"M Wang","year":"2020","journal-title":"BMJ Open."},{"key":"ref19","first-page":"e123-e133","article-title":"Trends in cardiometabolic risk factors in the Americas between 1980 and 2014: a pooled analysis of population-based surveys.","volume":"8","year":"2020","journal-title":"Lancet Glob. Health."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1471-2261-9-23","article-title":"The effect on cardiovascular risk factors of migration from rural to urban areas in Peru: PERU MIGRANT Study.","volume":"9","author":"J Miranda","year":"2009","journal-title":"BMC Cardiovasc. Disord."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1752-f","DOI":"10.1093\/ije\/dyx116","article-title":"Cohort Profile: The PERU MIGRANT Study-A prospective cohort study of rural dwellers, urban dwellers and rural-to-urban migrants in Peru.","volume":"46","author":"R Carrillo-Larco","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.16811350.v3","article-title":"PERU MIGRANT Study. Figshare.","author":"J Miranda","year":"2021","journal-title":"Dataset."},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008548","article-title":"Nationwide Impact of the 2017 American College of Cardiology\/American Heart Association Blood Pressure Guidelines on Stroke Survivors.","volume":"7","author":"A Lekoubou","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1-3","DOI":"10.6515\/ACS.201801_34(1).20171218A","article-title":"Our Stance towards the 2017 ACC\/AHA High Blood Pressure Clinical Practice Guideline: Has the Pendulum Swung Too Far?.","volume":"34","author":"T Wang","year":"2018","journal-title":"Acta Cardiol. Sin."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"74-80","DOI":"10.1097\/HPC.0000000000000045","article-title":"Agreement Between Cardiovascular Disease Risk Scores in Resource-Limited Settings: Evidence from 5 Peruvian Sites.","volume":"14","author":"J Bazo-Alvarez","year":"2015","journal-title":"Crit. Pathw. Cardiol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"771-778","DOI":"10.3949\/ccjm.85a.18028","article-title":"2017 ACC\/AHA hypertension guidelines: Toward tighter control.","volume":"85","author":"R Blonsky","year":"2018","journal-title":"Cleve. Clin. J. Med."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jash.2018.01.004","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines.","volume":"12","author":"R Brook","year":"2018","journal-title":"J. Am. Soc. Hypertens."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1187-1197","DOI":"10.1016\/j.jacc.2018.05.074","article-title":"2017 ACC\/AHA Blood Pressure Treatment Guideline Recommendations and Cardiovascular Risk.","volume":"72","author":"L Colantonio","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"374-378","DOI":"10.1038\/s41591-020-0754-2","article-title":"Effect of salt substitution on community-wide blood pressure and hypertension incidence.","volume":"26","author":"A Bernabe-Ortiz","year":"2020","journal-title":"Nat. Med."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"507-520","DOI":"10.1001\/jama.2013.284427","article-title":"2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8).","volume":"311","author":"P James","year":"2014","journal-title":"JAMA."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"327-334","DOI":"10.1161\/HYPERTENSIONAHA.118.12291","article-title":"Cardiovascular Disease and Mortality in Adults Aged >\/=60 Years According to Recommendations by the American College of Cardiology\/American Heart Association and American College of Physicians\/American Academy of Family Physicians.","volume":"73","author":"B Jaeger","year":"2019","journal-title":"Hypertension."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"572-581","DOI":"10.1001\/jamacardio.2018.1240","article-title":"Estimating the Association of the 2017 and 2014 Hypertension Guidelines With Cardiovascular Events and Deaths in US Adults: An Analysis of National DataAssociation of the 2014 and 2017 Hypertension Guidelines With Cardiovascular Events and Deaths in US AdultsAssociation of the 2014 and 2017 Hypertension Guidelines With Cardiovascular Events and Deaths in US Adults.","volume":"3","author":"J Bundy","year":"2018","journal-title":"JAMA Cardiol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"114-119","DOI":"10.4103\/aam.aam_6_17","article-title":"A profile of adverse effects of antihypertensive medicines in a tertiary care clinic in Nigeria.","volume":"16","author":"A Olowofela","year":"2017","journal-title":"Ann. Afr. Med."}],"updated-by":[{"DOI":"10.12688\/f1000research.73900.4","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000}}],"container-title":["F1000Research"],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/10-1134\/v3\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-1134\/v3\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-1134\/v3\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T08:50:13Z","timestamp":1701247813000},"score":9.758668,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/10-1134\/v3"}},"issued":{"date-parts":[[2023,4,12]]},"references-count":32,"URL":"https:\/\/doi.org\/10.12688\/f1000research.73900.3","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.146604.r221681","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.146604.r221681","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"published":{"date-parts":[[2023,4,12]]},"assertion":[{"value":"Approved with reservations, Approved with reservations","URL":"https:\/\/f1000research.com\/articles\/10-1134\/v3#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.142808.r160523, Annika Hoyer, Dina Voeltz, Biostatistics and Medical Biometry, Medical School OWL, Bielefeld University, Bielefeld, 24 Jan 2023, version 2, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/10-1134\/v2#referee-response-160523","order":0,"name":"referee-response-160523","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Antonio Bernabe-Ortiz<\/b>; \nPosted: 04 Apr 2023<\/i>; \n1. We do now understand the age cut-off at year 30 and thank the authors for clarification. Nonetheless, we are wondering how the new categorization is justified. With regards to blood pressure and mortality, we would think that particularly the age group 60+ might be at high risk and thus, more detailed analysis (i.e., splitting into further age group 60-69, 70-79, etc.) might be of interest. We kindly ask the authors for more details on the stratification choice. Overall, though, we still recommend including age as a covariate measured on a continuous scale to improve the power of the analysis.<\/b> \nResponse:<\/i><\/b> The categorization of the age variable is due to the fact that the sampling approach was stratified by age in that way (i.e., 30-39, 40-49, 50-59, and 60+). For instance, even we can adjust for that variable in different forms (i.e., using different cut-offs or in a continuous fashion), the best way would be to adjust for the form the variable was stratified. This was explained in the \u201cSettings and participants\u201d subheading in the Methods section. In addition, this was added in the Statistical analysis subheading: \u201c\nPotential confounders were selected under epidemiological criteria. Since the selection of the participant\u2019s sample was stratified by age (i.e., 30-39, 40-49, 50-59, 60+), such variable was included in that form in adjusted models.<\/i>\u201d \n2. Current guidelines used to report the results of observational studies such as STROBE clearly state that inferential measures should not be used for description of the study population. In line with that, we strongly suggest to delete all p-values from tables 1-3 and to simply describe the characteristics of the study participants. Further, and also as advanced by current guidelines, the use of p-values is not an appropriate criterion for selecting which confounders to adjust for in the analysis. Consequently, we advocate that any statement about potential associations based on single p-values should be avoided.<\/b> \nResponse:<\/i><\/b> We have deleted p-values from tables 1 to 3 as suggested. We have not selected confounders based on p-values, but in an epidemiological approach (pre-specified model). \n3. We thank the authors for rewriting the Statistical analysis section where they refer to the Kaplan-Meier estimator. In the text it now reads that the evaluation of the proportional hazard assumption is based on visual inspection of a graph. For higher transparency and better understanding, we would suggest to include the graph in the article or as supporting material.<\/b> \nResponse:<\/i><\/b>\n <\/b>We have included the figure in the manuscript as requested. We believe the figure does not add more information. Thus, we think the figure should be included in online material but F1000Research does not accept supplemental material. We leave the final decision to include the figure to the reviewer and the editor. \n4. We are pleased to see that the authors followed our recommendation and changed the term \u201cbivariate model\u201d. Though, the term \u201cbivariable model\u201d is still somewhat misleading and rather uncommon to use. We would suggest to simply refer to an \u201cassociation\u201d.<\/b> \nResponse:<\/i><\/b> We have deleted the word bivariable from the text of the manuscript. \n5. As suggested by the authors, we have reviewed the Public health relevance section for more information on how their study provides input e.g. for local decision making or public health implications. From our point of view, the article still lacks precise guidance in which way the estimates\/results from the study presented in the article can be used for decision making with respect to benefits and risks for patients with newly diagnosed hypertension. Consequently, we highly recommend that the authors explain the implications of their study in more detail and that they provide concrete ideas of possible future activities.<\/b> \nResponse:<\/i><\/b> This is an observational study looking at the association between two different guidelines for hypertension definition and all-cause mortality, and not a clinical trial to do decision making. However, according to our results, we have added some lines: \n\u201cTreatment must be guaranteed for hypertension (using JNC-7) and stage 2 hypertension (ACC\/AHA 2017) to reduce mortality risk. If this effect can be seen in pre-hypertension (JNC-7) and stage 1 hypertension (ACC\/AHA 2017) should be further assessed.\u201d<\/i> \n6. In our first review we noted that the authors were not consistent in their writing and with the vocabulary used in the tables, e.g. "stage 1" vs. "stage-1" vs. "stage I" (same applies for \u201cstage 2\u201d). In the reviewed article we still find inconsistencies, particularly comparing the Public health relevance section with the rest of the text.<\/b> \nResponse:<\/i><\/b> We have reviewed through manuscript, tables and figures to keep consistency.","URL":"https:\/\/f1000research.com\/articles\/10-1134\/v3#referee-comment-9541","order":1,"name":"referee-comment-9541","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.146604.r221681, Margarita Gutierrez, University of the Philippines Manila College of Pharmacy, Manila, 09 Nov 2023, version 3, 2 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/10-1134\/v3#referee-response-221681","order":2,"name":"referee-response-221681","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Antonio Bernabe-Ortiz<\/b>; \nPosted: 13 Nov 2023<\/i>; \nSample Size and Generalizability: While the study provides valuable insights, it is important to ensure that the sample size and characteristics of the study population are representative of the broader population. A larger and more diverse sample could enhance the generalizability of the findings.<\/b> \nResponse:<\/i><\/b> This is a secondary analysis of an existing dataset. The idea of the original study was to compare the cardiometabolic profile of three different populations (urban, rural-to-urban migrants, and rural dwellers). Even, we tried to take a random sample of participants for each population group, such selection was done in specific study sites using an age- and sex-stratification approach. Based on that, it is not possible to increase the sample size of the study. \nConfounding Factors: The study controlled for confounding factors, but it is essential to consider potential unmeasured confounders that might affect the relationship between blood pressure and mortality. A more comprehensive assessment of confounding variables, including lifestyle factors and comorbidities, would strengthen the study.<\/b> \nResponse:<\/i><\/b> We agree with the reviewer. Our adjusted model was built using epidemiological criteria and information available in the dataset. As a result, we did not include variables, important to control the model, but not present in the database. We have clarified that in the Statistical analysis section. In addition, we have added a comment about that in the Strengths and Limitations section: \n\u201c<\/i>\nSecond, some variables, relevant to understand the relationship between hypertension and all-cause mortality, were not available (e.g., diet patterns, salt consumption, among others).\u201d<\/i>   \nLong-Term Follow-Up: Ten years is a substantial follow-up period, but extending the observation period further could provide additional insights into the relationship between blood pressure and long-term mortality.<\/b> \nResponse:<\/i><\/b> As pointed out by the reviewer, extending observation period would be ideal, but currently, that is not possible. Available information was used for this manuscript. \nClinical Implications: The authors should provide recommendations for healthcare practitioners based on their findings. This could include guidance on blood pressure management strategies, especially considering the increased prevalence of hypertension when using ACC\/AHA 2017 guidelines.<\/b> \nResponse:<\/b> We would like to add a comment to provide recommendation for healthcare practitioners. However, this is an observational study looking at the association between two different guidelines for hypertension definition and all-cause mortality, and not a clinical trial to do decision making. Nevertheless, we have included a couple of sentences have been added: \n\u201cFrom the clinical perspective, a tailored follow-up of those individuals with pre-hypertension may be required to decide appropriate treatment, even high-risk stratification may be considered. In addition to that, a combination of population-wide interventions may be also needed.\u201d<\/i> \nDiscussion of Potential Biases: The study should address potential biases, such as selection bias or measurement bias, and explain how these were minimized or managed.<\/b> \nResponse:<\/i><\/b> Thanks for the suggestion. We have added that in the Strengths and Limitations section: \n\u201c<\/i>\nFourth, selection bias can be an issue as studied population groups were selected in specific sites and may not be totally representative of the general population. In addition, measurement bias may be present. However, standard procedures were used to assess blood pressure levels.\u201d<\/i> \nPublic Health Impact: The study mentions the capacity of healthcare systems to manage a larger number of hypertensive patients. A discussion of the potential public health impact of increased hypertension prevalence and its associated resource implications would be valuable.<\/b> Response: We have discussed this point in our manuscript. We have extended some topics: \n\u201c<\/i>\nPeru is a middle-income country with a fragile and fragmented healthcare system, with poor response to the challenges of chronic conditions. Increasing the number of people with hypertension may benefit those with blood pressure levels in the range 130\u2013139\/80\u201389 mm Hg, but would represent a major investment (i.e., human resources, budget and time) so that these patients can receive adequate treatment, management, and follow-up.\u201d<\/i>","URL":"https:\/\/f1000research.com\/articles\/10-1134\/v3#referee-comment-10564","order":3,"name":"referee-comment-10564","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"RMC-L is supported by a Wellcome Trust International Training Fellowship, London, UK (214185\/Z\/18\/Z). AB-O (103994\/Z\/14\/Z) and JJM (074833\/Z\/04\/Z, 20517\/Z\/16\/Z) were supported by the Wellcome Trust, London, UK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]},{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:34Z","timestamp":1772168974333,"version":"3.50.1"},"reference-count":32,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["074833\/Z\/04\/Z"],"award-info":[{"award-number":["074833\/Z\/04\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["214185\/Z\/18\/Z"],"award-info":[{"award-number":["214185\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["103994\/Z\/14\/Z"],"award-info":[{"award-number":["103994\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome","award":["20517\/Z\/16\/Z"],"award-info":[{"award-number":["20517\/Z\/16\/Z"]}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"\n Background<\/ns4:bold>\n <\/ns4:p>\n The long-term impact of elevated blood pressure on mortality outcomes has been recently revisited due to proposed changes in cut-offs for hypertension. This study aimed at assessing the association between high blood pressure levels and 10-year mortality using the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) and the American College of Cardiology and the American Heart Association (ACC\/AHA) 2017 blood pressure guidelines.<\/ns4:p>\n \n Methods<\/ns4:bold>\n <\/ns4:p>\n Data analysis of the PERU MIGRANT Study, a prospective ongoing cohort, was used. The outcome of interest was 10-year all-cause mortality, and exposures were blood pressure categories according to the JNC-7 and ACC\/AHA 2017 guidelines. Log-rank test, Kaplan-Meier and Cox regression models were used to assess the associations of interest controlling for confounders. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated.<\/ns4:p>\n \n Results<\/ns4:bold>\n <\/ns4:p>\n A total of 976 records, mean age of 60.4 (SD: 11.4), 513 (52.6%) women, were analyzed. Hypertension prevalence at baseline almost doubled from 16.0% (95% CI 13.7%\u201318.4%) to 31.3% (95% CI 28.4%\u201334.3%), using the JNC-7 and ACC\/AHA 2017 definitions, respectively. Sixty three (6.4%) participants died during the 10-year follow-up, equating to a mortality rate of 3.6 (95% CI 2.4\u20134.7) per 1000 person-years. Using JNC-7, and compared to those with normal blood pressure, those with pre-hypertension and hypertension had 2.1-fold and 5.1-fold increased risk of death, respectively. Similar mortality effect sizes were estimated using ACC\/AHA 2017 for stage-1 and stage-2 hypertension.<\/ns4:p>\n \n Conclusions<\/ns4:bold>\n <\/ns4:p>\n Blood pressure levels under two different definitions increased the risk of 10-year all-cause mortality. Hypertension prevalence doubled using ACC\/AHA 2017 compared to JNC-7. The choice of blood pressure cut-offs to classify hypertension categories need to be balanced against the patients benefit and the capacities of the health system to adequately handle a large proportion of new patients.<\/ns4:p>","DOI":"10.12688\/f1000research.73900.1","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T10:05:08Z","timestamp":1636452308000},"page":"1134","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Blood pressure and 10-year all-cause mortality: Findings from the PERU MIGRANT Study"],"prefix":"10.12688","volume":"10","author":[{"given":"Aida","family":"Hidalgo-Benites","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Senosain-Leon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo M.","family":"Carrillo-Larco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ruiz-Alejos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Gilman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam","family":"Smeeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4738-5468","authenticated-orcid":false,"given":"J. Jaime","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-1376","authenticated-orcid":false,"given":"Antonio","family":"Bernab\u00e9-Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1603-1658","DOI":"10.1016\/S0140-6736(16)31460-X","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.","volume":"388","year":"2016","journal-title":"Lancet."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2224-2260","DOI":"10.1016\/S0140-6736(12)61766-8","article-title":"A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010.","volume":"380","author":"S Lim","year":"2012","journal-title":"Lancet."},{"key":"ref4","first-page":"37-55","article-title":"Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants.","volume":"389","year":"2017","journal-title":"Lancet."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1206-1252","DOI":"10.1161\/01.HYP.0000107251.49515.c2","article-title":"Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.","volume":"42","author":"A Chobanian","year":"2003","journal-title":"Hypertension."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e426-e483","DOI":"10.1161\/CIR.0000000000000597","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines.","volume":"138","author":"P Whelton","year":"2018","journal-title":"Circulation."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"956-960","DOI":"10.1016\/j.amjmed.2017.12.049","article-title":"Baseline Blood Pressure, the 2017 ACC\/AHA High Blood Pressure Guidelines, and Long-Term Cardiovascular Risk in SPRINT.","volume":"131","author":"M Vaduganathan","year":"2018","journal-title":"Am. J. Med."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"399-410","DOI":"10.23736\/S0026-4725.19.04965-X","article-title":"Implications of the new 2017 American College of Cardiology\/American Aeart Association Guidelines for Hypertension.","volume":"67","author":"W Aronow","year":"2019","journal-title":"Minerva Cardioangiol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"6382","DOI":"10.1038\/s41598-019-42809-3","article-title":"Status of Hypertension in Tehran: Potential impact of the ACC\/AHA 2017 and JNC7 Guidelines, 2012\u20132015.","volume":"9","author":"S Asgari","year":"2019","journal-title":"Sci. Rep."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"109-118","DOI":"10.1161\/CIRCULATIONAHA.117.032582","article-title":"Potential US Population Impact of the 2017 ACC\/AHA High Blood Pressure Guideline.","volume":"137","author":"P Muntner","year":"2018","journal-title":"Circulation."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s11906-019-0906-2","article-title":"Impact of the 2017 American College of Cardiology\/American Heart Association Blood Pressure Guidelines on the Next Blood Pressure Guidelines in Asia.","volume":"21","author":"N Nakagawa","year":"2019","journal-title":"Curr. Hypertens. Rep."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"545-556","DOI":"10.4067\/S0034-98872019000500545","article-title":"Changes in the prevalence of hypertension in Peru using the new guideline of the American College of Cardiology.","volume":"147","author":"A Hernandez-Vasquez","year":"2019","journal-title":"Rev. Med. Chil."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"668-670","DOI":"10.1177\/2047487318799489","article-title":"New 2017 ACC\/AHA hypertension guideline: Implications for a Latin American country like Peru.","volume":"26","author":"A Hern\u00e1ndez-V\u00e1squez","year":"2019","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1256-1264","DOI":"10.1161\/HYPERTENSIONAHA.106.083592","article-title":"Predictive utility of pulse pressure and other blood pressure measures for cardiovascular outcomes.","volume":"49","author":"W Mosley","year":"2007","journal-title":"Hypertension."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"345-354","DOI":"10.1177\/2047487319862066","article-title":"Associations of blood pressure categories defined by 2017 ACC\/AHA guidelines with mortality in China: Pooled results from three prospective cohorts.","volume":"27","author":"N Liu","year":"2020","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"678-685","DOI":"10.1111\/jch.12375","article-title":"Brachial pulse pressure and cardiovascular or all-cause mortality in the general population: a meta-analysis of prospective observational studies.","volume":"16","author":"L Zhao","year":"2014","journal-title":"J. Clin. Hypertens. (Greenwich)."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"775-781","DOI":"10.1001\/jamacardio.2017.1421","article-title":"Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Network Meta-analysis.","volume":"2","author":"J Bundy","year":"2017","journal-title":"JAMA Cardiol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e035190","DOI":"10.1136\/bmjopen-2019-035190","article-title":"Association between blood pressure levels and cardiovascular deaths: a 20-year follow-up study in rural China.","volume":"10","author":"M Wang","year":"2020","journal-title":"BMJ Open."},{"key":"ref19","first-page":"e123-e133","article-title":"Trends in cardiometabolic risk factors in the Americas between 1980 and 2014: a pooled analysis of population-based surveys.","volume":"8","year":"2020","journal-title":"Lancet Glob. Health."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1471-2261-9-23","article-title":"The effect on cardiovascular risk factors of migration from rural to urban areas in Peru: PERU MIGRANT Study.","volume":"9","author":"J Miranda","year":"2009","journal-title":"BMC Cardiovasc. Disord."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1752-f","DOI":"10.1093\/ije\/dyx116","article-title":"Cohort Profile: The PERU MIGRANT Study-A prospective cohort study of rural dwellers, urban dwellers and rural-to-urban migrants in Peru.","volume":"46","author":"R Carrillo-Larco","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.16811350.v3","article-title":"PERU MIGRANT Study. Figshare.","author":"J Miranda","year":"2021","journal-title":"Dataset."},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008548","article-title":"Nationwide Impact of the 2017 American College of Cardiology\/American Heart Association Blood Pressure Guidelines on Stroke Survivors.","volume":"7","author":"A Lekoubou","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1-3","DOI":"10.6515\/ACS.201801_34(1).20171218A","article-title":"Our Stance towards the 2017 ACC\/AHA High Blood Pressure Clinical Practice Guideline: Has the Pendulum Swung Too Far?.","volume":"34","author":"T Wang","year":"2018","journal-title":"Acta Cardiol. Sin."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"74-80","DOI":"10.1097\/HPC.0000000000000045","article-title":"Agreement Between Cardiovascular Disease Risk Scores in Resource-Limited Settings: Evidence from 5 Peruvian Sites.","volume":"14","author":"J Bazo-Alvarez","year":"2015","journal-title":"Crit. Pathw. Cardiol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"771-778","DOI":"10.3949\/ccjm.85a.18028","article-title":"2017 ACC\/AHA hypertension guidelines: Toward tighter control.","volume":"85","author":"R Blonsky","year":"2018","journal-title":"Cleve. Clin. J. Med."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jash.2018.01.004","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines.","volume":"12","author":"R Brook","year":"2018","journal-title":"J. Am. Soc. Hypertens."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1187-1197","DOI":"10.1016\/j.jacc.2018.05.074","article-title":"2017 ACC\/AHA Blood Pressure Treatment Guideline Recommendations and Cardiovascular Risk.","volume":"72","author":"L Colantonio","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"374-378","DOI":"10.1038\/s41591-020-0754-2","article-title":"Effect of salt substitution on community-wide blood pressure and hypertension incidence.","volume":"26","author":"A Bernabe-Ortiz","year":"2020","journal-title":"Nat. Med."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"507-520","DOI":"10.1001\/jama.2013.284427","article-title":"2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8).","volume":"311","author":"P James","year":"2014","journal-title":"JAMA."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"327-334","DOI":"10.1161\/HYPERTENSIONAHA.118.12291","article-title":"Cardiovascular Disease and Mortality in Adults Aged >\/=60 Years According to Recommendations by the American College of Cardiology\/American Heart Association and American College of Physicians\/American Academy of Family Physicians.","volume":"73","author":"B Jaeger","year":"2019","journal-title":"Hypertension."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"572-581","DOI":"10.1001\/jamacardio.2018.1240","article-title":"Estimating the Association of the 2017 and 2014 Hypertension Guidelines With Cardiovascular Events and Deaths in US Adults: An Analysis of National DataAssociation of the 2014 and 2017 Hypertension Guidelines With Cardiovascular Events and Deaths in US AdultsAssociation of the 2014 and 2017 Hypertension Guidelines With Cardiovascular Events and Deaths in US Adults.","volume":"3","author":"J Bundy","year":"2018","journal-title":"JAMA Cardiol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"114-119","DOI":"10.4103\/aam.aam_6_17","article-title":"A profile of adverse effects of antihypertensive medicines in a tertiary care clinic in Nigeria.","volume":"16","author":"A Olowofela","year":"2017","journal-title":"Ann. Afr. Med."}],"updated-by":[{"DOI":"10.12688\/f1000research.73900.4","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000}},{"DOI":"10.12688\/f1000research.73900.3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000}},{"DOI":"10.12688\/f1000research.73900.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000}}],"container-title":["F1000Research"],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/10-1134\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-1134\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-1134\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T04:45:20Z","timestamp":1681274720000},"score":9.758668,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/10-1134\/v1"}},"issued":{"date-parts":[[2021,11,9]]},"references-count":32,"URL":"https:\/\/doi.org\/10.12688\/f1000research.73900.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.77589.r144138","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.77589.r144138","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"published":{"date-parts":[[2021,11,9]]},"assertion":[{"value":"Approved with reservations","URL":"https:\/\/f1000research.com\/articles\/10-1134\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.77589.r144138, Annika Hoyer, Biostatistics and Medical Biometry, Medical School OWL, Bielefeld University, Bielefeld, 22 Jul 2022, version 1, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/10-1134\/v1#referee-response-144138","order":0,"name":"referee-response-144138","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Antonio Bernabe-Ortiz<\/b>; \nPosted: 02 Jan 2023<\/i>; \nREVIEWER 1 - ANNIKA HOYER<\/b> The article is well written and spreads light on the association between blood pressure and mortality depending on the cut-off for defining high blood pressure in the Peruvian population. However, we have some comments and suggestions that may improve the article: \nIn the introduction, it was written that "prevalence of hypertension was estimated to be 24.1% and 20.1% in men and women, respectively". It would be helpful to add the year that corresponds to these prevalence's.<\/b> \nResponse:<\/i><\/b> We have rewritten the sentence to clarify this point. Now, it reads: \u201c\n\u2026and the prevalence of hypertension in 2015 was estimated to be 24.1% and 20.1% in men and women, respectively.<\/i>\u201d   \nIn the introduction, we would suggest to briefly discuss the reasons that initially led to a reformulation of the definition of hypertension, i.e., what were the motives of the ACC\/AHA to change the cut-off levels, and why did they introduce four instead of three categories?<\/b> \nResponse:<\/i><\/b> Although the focus of the paper was not to define the motivations of the ACC\/AHA to change the cut-off levels, we have introduced some lines regarding this point. Now, it reads: \u201c\nIn 2017, as part of the ongoing review process of full guidelines commissioned in about 6-year cycles, the American College of Cardiology and the American Heart Association (ACC\/AHA 2017) changed the proposed cut-off points used for defining hypertension, \u2026<\/i>\u201d \nIn the "Settings and participants" section, it remains unclear what is meant by an "age and stratified sampling approach" which is used to select participants of the PERU MIGRANT study. This should be clarified.<\/b> \nResponse:<\/i><\/b> Thanks for noticing these typos. We have corrected this section to better clarify this point. Now, it reads: \u201c\nParticipants were randomly selected using an age- (30\u201339, 40\u201349, 50\u201359, and 60+) and sex- stratified sampling approach, utilizing the most up-to-date census in the study area.<\/i>\u201d \nWhat is the reason for splitting age into two categories (< 50 vs. >= 50)? With respect to the power of the analysis, it would be far better to include age as a covariate measured on a continuous scale.<\/b> \nResponse: <\/i><\/b>Age is considered as confounder in our models. However, we have changed the categorization of age in four categories based on the stratification of the sample (30-39, 40-49, 50-69, and 60+ years). We have accordingly modified paper results. Overall, HR reduced after controlling for age in 4 categories, but are yet consistent. \nWe were also wondering about the reason for the age cut-off at year 30? Is there a reason why no children, adolescents and any other people below 30 years are excluded?<\/b> \nResponse:<\/i><\/b> The original study at baseline recruited participants aged 30 years and over, and this was done because cardiovascular conditions are most common among subjects aged \u2265 30 years. This is a secondary analysis of that data and for instance no data of other age group was available. \nWe would strongly recommend to delete all p-values from tables 1-3 and to purely report on the characteristics of the population. This would be in line with current guidelines used to report the results of observational studies (e.g., STROBE).<\/b> \nResponse: <\/i><\/b>We have decided to keep the p-values in Tables 1 to 3 as they are important to show association of variables with the exposures and outcome of interest, and for instance, the role of potential confounders. We ask the editor to decide about this topic if relevant. \nWe are a bit confused about the term "Kaplan-Meier test" and would suggest that the authors explain in more detail what specific kind of statistical test they used. If they are interested in the association between the exposure and outcome, it would be also possible to assess the estimated hazard ratios (HR) and their confidence intervals based on the proportional hazard regression approach.<\/b> \nResponse:<\/i><\/b> We have rewritten this section to clarify this point. It now reads: \u201c\nA plot of the Kaplan-Meier estimator was used to evaluate the assumption of proportional hazards graphically, whereas such assessment was done in post-hoc analysis using the Schoenfeld residuals.<\/i>\u201d \nDrawing conclusions about potential associations between variables based on univariate p-values (tables 1-3) alone should be viewed critically because the PERU MIGRANT study is a cohort study. That means that there are indeed confounding variables that are not adjusted for in tables 1-3. Again, we would recommend to delete all p-values from tables 1-3, to simply describe the characteristics of the study participants and to avoid statements about potential associations based on single p-values.<\/b> \nResponse: <\/i><\/b>We only described the findings in our Results section. To avoid confusion, we have rewritten this section as follows: \u201c\nIn both definitions, high blood pressure levels were more frequent among males, older subjects, migrant and urban dwellers, as well as those with obesity and those with type 2 diabetes mellitus<\/i>\u201d. \nThe term "bivariate model" should be avoided when only the association between two variables is meant because in a bivariate analysis, the outcome consists of two variables.<\/b> \nResponse:<\/i><\/b> We have changed the term by using \u201cbivariable model\u201d.   \nWith respect to the Cox model, we would suggest to interpret the HR in terms of hazards and not risks. That means, a HR of 5.1 indicates a 5.1-fold increased hazard (and not a risk). It should also be added compared to which group the hazard is increased (or decreased).<\/b> \nResponse:<\/i><\/b> We have rewritten this section as suggested: \u201c\nUsing the JNC-7 guideline and compared to those with normal blood pressure, those with pre-hypertension and hypertension had 2-fold and 3.4-fold increased hazard of death, respectively. On the other hand, using the ACC\/AHA 2017 definition and compared to those with normal blood pressure, stage 1 and stage 2 hypertension were associated with a 2.5- and 3.5-fold increase in the hazard of mortality.<\/i>\u201d \nWe were wondering if the authors took account for possible left truncation which maybe occurred because the minimum age of entry is 30 years.<\/b> \nResponse:<\/i><\/b> Although left truncation can be present as minimum age at study entry was 30 years, we believe the effect can be negligible as the prevalence of hypertension in Peruvian population aged <30 years is very low (<3%). However, we have added that in the limitations section: \u201c\nThird, although left truncation can be present as subjects <30 years were excluded, the potential effect of such limitation may be negligible as the prevalence of hypertension is low in that age group.<\/i>\u201d \nWhen discussing the AIC and BIC for the models, the authors should be more precise and state which models were compared and which result refers to which comparison.<\/b> \nResponse:<\/i><\/b> We have clarified this point in the Statistical analysis section: \u201c\nUsing full-adjusted models, Akaike and Bayesian information criteria (AIC and BIC) as well as the Nelson-Aalen graphs were utilized to compare both blood pressure level definitions and their impact on mortality.<\/i>\u201d In addition, this has been also clarified in the Results section: \u201c\nWhen comparing adjusted models, AIC and BIC were very similar (AIC was 741.3 for JNC-7 vs. 742.2 for ACC\/AHA 2017, whereas BIC was 824.1 for JNC-7 vs. 829.9 for ACC\/AHA 2017), highlighting no difference between models.<\/i>\u201d \nIn the section where the authors compare their findings with other studies, the dates of the studies mentioned should be added.<\/b> \nResponse:<\/i><\/b> We have modified this section accordingly. We have added dates of recruitment of the studies. \nIn the introduction and conclusion, the authors highlight that three different population groups were separately considered. Though, in the result section this is not further taken up. We would recommend that the authors explain why the distinction is yet so important and if the findings of their study differ with regards to the different groups.<\/b> \nResponse:<\/i><\/b> We have not included population groups in the Introduction section. However, we have included such information in the Methods section as it is needed to describe the cohort used in the analysis, and in the Discussion section, especially in the Strength and Limitations section. We have dropped this section as it does not affect the interpretation of the results. \nFrom our point of view, the conclusion that 46% of deaths could be avoided using the JNC-7 definition, and 66.7% using the ACC\/AHA 2017 guideline if hypertension is treated, seem a bit speculative. Could deaths be really prevented if people are classified as being hypertensive? We think such a conclusion cannot be drawn from a cohort study and the analysis done by the authors because it is not known if hypertension was the reason for all reported deaths. Only associations are seen. This should be discussed in more detail. We would also suggest to weaken this conclusion.<\/b> \nResponse:<\/i><\/b> This section highlighted by the reviewer is not a conclusion, it is only a finding described taking into account the limitations of the study (only observational). However, based on the comment, we have deleted this section.   \nWe would suggest that the authors explain the implications of their study in more detail. As a concluding remark, they have written that their estimates can be used to inform local decision making. We were wondering how this can be achieved based on the estimated HRs because they do not differ that much between the two definitions of hypertension. It would be helpful to describe in which way these estimates can be used for decision making with respect to benefits and risks for patients with newly diagnosed hypertension.<\/b> \nResponse:<\/i><\/b> We believe all these topics are discussed in the Public Health Relevance section: (1) the increase in the prevalence of hypertension, and the use of medications would start at a lower blood pressure level, with the subsequent increase in care costs at the health system which will be translated to the patient. So, countries like Peru are not prepared for that change, and for instance, it will require appropriate strategies to face them. In addition, we also discuss in this section the increase of side effects due to the greater use of anti-hypertensive medication. \nThe authors may want to add a decimal separator (e.g. 1,000 person years).<\/b> \nResponse:<\/i><\/b> This will depend on the journal style and not necessarily on us. The paper has been adapted for review by editors, so we believe this may be not important at all. \nWith regards to abbreviations: They should be introduced when first used (e.g. page 9 "CV risk scores"), and only introduced when needed (e.g. STEPs is never referred to again). First, the full name should be spelled and then the abbreviation should be added in brackets (e.g., Systolic Blood Pressure Intervention Trial Study (SPRINT)). Abbreviations in the abstract should be avoided (e.g., HR).<\/b> \nResponse:<\/i><\/b> The meaning of SPRINT Study is in the introduction of the paper. The use of abbreviations in the abstract depends on the journal style. We have nevertheless described the meaning of such abbreviations.   \nThe authors should be consistent in their writing and with the vocabulary used in the tables. E.g. "stage 1" vs. "stage-1" vs. "stage I" (same applies for \u201cstage 2\u201d)<\/b> \nand "Las Pampas de San Juan de Miraflores" vs. <\/b>\n"San Juan de Miraflores".<\/b> \nResponse:<\/i><\/b> We have modified the manuscript to be consistent with our terms.   \nAbstract: The data of the PERU MIGRANT Study was used, not the analysis, we think.<\/b> \nResponse:<\/i><\/b> We have modified this section.   \nPage 3, Settings and Participants: The sentence \u201cIn Lima, a highly urbanized city, Las Pampas de San Juan de Miraflores was selected as the urban environment,\u201d should be rephrased as follows \u201cLas Pampas de San Juan de Miraflores, a highly urbanized city in Lima, Peru, was selected as the urban environment....\u201d.<\/b> \nResponse:<\/i><\/b> We have modified this section as suggested.   \nPage 4: There is a typo in the Procedures section. It should be read \u201cmeasured\u201d instead of \u201cmeasure\u201d in the following sentence: \u201cBlood pressure was measured in seated position after a resting period of five minutes.\u201d<\/b> \nResponse:<\/i><\/b> We have modified this section as suggested.   \nPage 4: Another typo is found in the Ethics section. Instead of \u201cin UK\u201d the authors should write \u201cin the UK\u201d at the end of the first sentence of the mentioned paragraph.<\/b> \nResponse:<\/i><\/b> We have modified this section as suggested.   \nPage 7: When discussing the main findings, we would suggest reformulating the following sentence on page 7 to \u201cHigh blood pressure levels have been found to increase the risk of 10-year all-cause mortality (please add a reference) \u2026\u201d.<\/b> \nResponse:<\/i><\/b> This sentence is not part of a reference but instead the interpretation of our findings. We have clarified that by adding an introduction phase as follows: \u201c\nAccording to our findings, high blood pressure levels increased the risk of 10-year all-cause mortality, \u2026<\/i>\u201d","URL":"https:\/\/f1000research.com\/articles\/10-1134\/v1#referee-comment-9179","order":1,"name":"referee-comment-9179","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Antonio Bernabe-Ortiz<\/b>; \nPosted: 04 Jan 2023<\/i>; The article is well written and spreads light on the association between blood pressure and mortality depending on the cut-off for defining high blood pressure in the Peruvian population. However, we have some comments and suggestions that may improve the article: \nIn the introduction, it was written that "prevalence of hypertension was estimated to be 24.1% and 20.1% in men and women, respectively". It would be helpful to add the year that corresponds to these prevalence's.<\/b> \nResponse:<\/i><\/b> We have rewritten the sentence to clarify this point. Now, it reads: \u201c\n\u2026and the prevalence of hypertension in 2015 was estimated to be 24.1% and 20.1% in men and women, respectively.<\/i>\u201d   \nIn the introduction, we would suggest to briefly discuss the reasons that initially led to a reformulation of the definition of hypertension, i.e., what were the motives of the ACC\/AHA to change the cut-off levels, and why did they introduce four instead of three categories?<\/b> \nResponse:<\/i><\/b> Although the focus of the paper was not to define the motivations of the ACC\/AHA to change the cut-off levels, we have introduced some lines regarding this point. Now, it reads: \u201c\nIn 2017, as part of the ongoing review process of full guidelines commissioned in about 6-year cycles, the American College of Cardiology and the American Heart Association (ACC\/AHA 2017) changed the proposed cut-off points used for defining hypertension, \u2026<\/i>\u201d \nIn the "Settings and participants" section, it remains unclear what is meant by an "age and stratified sampling approach" which is used to select participants of the PERU MIGRANT study. This should be clarified.<\/b> \nResponse:<\/i><\/b> Thanks for notice these typos. We have corrected this section to better clarify this point. Now, it reads: \u201c\nParticipants were randomly selected using an age- (30\u201339, 40\u201349, 50\u201359, and 60+) and sex- stratified sampling approach, utilizing the most up-to-date census in the study area.<\/i>\u201d \nWhat is the reason for splitting age into two categories (< 50 vs. >= 50)? With respect to the power of the analysis, it would be far better to include age as a covariate measured on a continuous scale.<\/b> \nResponse: <\/i><\/b>Age is considered as confounder in our models. However, we have changed the categorization of age in four categories based on the stratification of the sample (30-39, 40-49, 50-69, and 60+ years). We have accordingly modified paper results. Overall, HR reduced after controlling for age in 4 categories, but are yet consistent. \nWe were also wondering about the reason for the age cut-off at year 30? Is there a reason why no children, adolescents and any other people below 30 years are excluded?<\/b> \nResponse:<\/i><\/b> The original study at baseline recruited participants aged 30 years and over, and this was done because cardiovascular conditions are most common among subjects aged \u2265 30 years. This is a secondary analysis of that data and for instance no data of other age group was available. \nWe would strongly recommend to delete all p-values from tables 1-3 and to purely report on the characteristics of the population. This would be in line with current guidelines used to report the results of observational studies (e.g., STROBE).<\/b> \nResponse: <\/i><\/b>We have decided to keep the p-values in Tables 1 to 3 as they are important to show association of variables with the exposures and outcome of interest, and for instance, the role of potential confounders. We ask the editor to decide about this topic if relevant. \nWe are a bit confused about the term "Kaplan-Meier test" and would suggest that the authors explain in more detail what specific kind of statistical test they used. If they are interested in the association between the exposure and outcome, it would be also possible to assess the estimated hazard ratios (HR) and their confidence intervals based on the proportional hazard regression approach.<\/b> \nResponse:<\/i><\/b> We have rewritten this section to clarify this point. It now reads: \u201c\nA plot of the Kaplan-Meier estimator was used to evaluate the assumption of proportional hazards graphically, whereas such assessment was done in post-hoc analysis using the Schoenfeld residuals.<\/i>\u201d \nDrawing conclusions about potential associations between variables based on univariate p-values (tables 1-3) alone should be viewed critically because the PERU MIGRANT study is a cohort study. That means that there are indeed confounding variables that are not adjusted for in tables 1-3. Again, we would recommend to delete all p-values from tables 1-3, to simply describe the characteristics of the study participants and to avoid statements about potential associations based on single p-values.<\/b> \nResponse: <\/i><\/b>We only described the findings in our Results section. To avoid confusion, we have rewritten this section as follows: \u201c\nIn both definitions, high blood pressure levels were more frequent among males, older subjects, migrant and urban dwellers, as well as those with obesity and those with type 2 diabetes mellitus<\/i>\u201d. \nThe term "bivariate model" should be avoided when only the association between two variables is meant because in a bivariate analysis, the outcome consists of two variables.<\/b> \nResponse:<\/i><\/b> We have changed the term by using \u201cbivariable model\u201d.   \nWith respect to the Cox model, we would suggest to interpret the HR in terms of hazards and not risks. That means, a HR of 5.1 indicates a 5.1-fold increased hazard (and not a risk). It should also be added compared to which group the hazard is increased (or decreased).<\/b> \nResponse:<\/i><\/b> We have rewritten this section as suggested: \u201c\nUsing the JNC-7 guideline and compared to those with normal blood pressure, those with pre-hypertension and hypertension had 2-fold and 3.4-fold increased hazard of death, respectively. On the other hand, using the ACC\/AHA 2017 definition and compared to those with normal blood pressure, stage 1 and stage 2 hypertension were associated with a 2.5- and 3.5-fold increase in the hazard of mortality.<\/i>\u201d \nWe were wondering if the authors took account for possible left truncation which maybe occurred because the minimum age of entry is 30 years.<\/b> \nResponse:<\/i><\/b> Although left truncation can be present as minimum age at study entry was 30 years, we believe the effect can be negligible as the prevalence of hypertension in Peruvian population aged <30 years is very low (<3%). However, we have added that in the limitations section: \u201c\nThird, although left truncation can be present as subjects <30 years were excluded, the potential effect of such limitation may be negligible as the prevalence of hypertension is low in that age group.<\/i>\u201d \nWhen discussing the AIC and BIC for the models, the authors should be more precise and state which models were compared and which result refers to which comparison.<\/b> \nResponse:<\/i><\/b> We have clarified this point in the Statistical analysis section: \u201c\nUsing full-adjusted models, Akaike and Bayesian information criteria (AIC and BIC) as well as the Nelson-Aalen graphs were utilized to compare both blood pressure level definitions and their impact on mortality.<\/i>\u201d In addition, this has been also clarified in the Results section: \u201c\nWhen comparing adjusted models, AIC and BIC were very similar (AIC was 741.3 for JNC-7 vs. 742.2 for ACC\/AHA 2017, whereas BIC was 824.1 for JNC-7 vs. 829.9 for ACC\/AHA 2017), highlighting no difference between models.<\/i>\u201d \nIn the section where the authors compare their findings with other studies, the dates of the studies mentioned should be added.<\/b> \nResponse:<\/i><\/b> We have modified this section accordingly. We have added dates of recruitment of the studies. \nIn the introduction and conclusion, the authors highlight that three different population groups were separately considered. Though, in the result section this is not further taken up. We would recommend that the authors explain why the distinction is yet so important and if the findings of their study differ with regards to the different groups.<\/b> \nResponse:<\/i><\/b> We have not included population groups in the Introduction section. However, we have included such information in the Methods section as it is needed to describe the cohort used in the analysis, and in the Discussion section, especially in the Strength and Limitations section. We have dropped this section as it does not affect the interpretation of the results. \nFrom our point of view, the conclusion that 46% of deaths could be avoided using the JNC-7 definition, and 66.7% using the ACC\/AHA 2017 guideline if hypertension is treated, seem a bit speculative. Could deaths be really prevented if people are classified as being hypertensive? We think such a conclusion cannot be drawn from a cohort study and the analysis done by the authors because it is not known if hypertension was the reason for all reported deaths. Only associations are seen. This should be discussed in more detail. We would also suggest to weaken this conclusion.<\/b> \nResponse:<\/i><\/b> This section highlighted by the reviewer is not a conclusion, it is only a finding described taking into account the limitations of the study (only observational). However, based on the comment, we have deleted this section.   \nWe would suggest that the authors explain the implications of their study in more detail. As a concluding remark, they have written that their estimates can be used to inform local decision making. We were wondering how this can be achieved based on the estimated HRs because they do not differ that much between the two definitions of hypertension. It would be helpful to describe in which way these estimates can be used for decision making with respect to benefits and risks for patients with newly diagnosed hypertension.<\/b> \nResponse:<\/i><\/b> We believe all these topics are discussed in the Public Health Relevance section: (1) the increase in the prevalence of hypertension, and the use of medications would start at a lower blood pressure level, with the subsequent increase in care costs at the health system which will be translated to the patient. So, countries like Peru are not prepared for that change, and for instance, it will require appropriate strategies to face them. In addition, we also discuss in this section the increase of side effects due to the greater use of anti-hypertensive medication. \nThe authors may want to add a decimal separator (e.g. 1,000 person years).<\/b> \nResponse:<\/i><\/b> This will depend on the journal style and not necessarily on us. The paper has been adapted for review by editors, so we believe this may be not important at all. \nWith regards to abbreviations: They should be introduced when first used (e.g. page 9 "CV risk scores"), and only introduced when needed (e.g. STEPs is never referred to again). First, the full name should be spelled and then the abbreviation should be added in brackets (e.g., Systolic Blood Pressure Intervention Trial Study (SPRINT)). Abbreviations in the abstract should be avoided (e.g., HR).<\/b> \nResponse:<\/i><\/b> The meaning of SPRINT Study is in the introduction of the paper. The use of abbreviations in the abstract depends on the journal style. We have nevertheless described the meaning of such abbreviations.   \nThe authors should be consistent in their writing and with the vocabulary used in the tables. E.g. "stage 1" vs. "stage-1" vs. "stage I" (same applies for \u201cstage 2\u201d)<\/b> \nand "Las Pampas de San Juan de Miraflores" vs. <\/b>\n"San Juan de Miraflores".<\/b> \nResponse:<\/i><\/b> We have modified the manuscript to be consistent with our terms.   \nAbstract: The data of the PERU MIGRANT Study was used, not the analysis, we think.<\/b> \nResponse:<\/i><\/b> We have modified this section.   \nPage 3, Settings and Participants: The sentence \u201cIn Lima, a highly urbanized city, Las Pampas de San Juan de Miraflores was selected as the urban environment,\u201d should be rephrased as follows \u201cLas Pampas de San Juan de Miraflores, a highly urbanized city in Lima, Peru, was selected as the urban environment....\u201d.<\/b> \nResponse:<\/i><\/b> We have modified this section as suggested.   \nPage 4: There is a typo in the Procedures section. It should be read \u201cmeasured\u201d instead of \u201cmeasure\u201d in the following sentence: \u201cBlood pressure was measured in seated position after a resting period of five minutes.\u201d<\/b> \nResponse:<\/i><\/b> We have modified this section as suggested.   \nPage 4: Another typo is found in the Ethics section. Instead of \u201cin UK\u201d the authors should write \u201cin the UK\u201d at the end of the first sentence of the mentioned paragraph.<\/b> \nResponse:<\/i><\/b> We have modified this section as suggested.   \nPage 7: When discussing the main findings, we would suggest reformulating the following sentence on page 7 to \u201cHigh blood pressure levels have been found to increase the risk of 10-year all-cause mortality (please add a reference) \u2026\u201d.<\/b> \nResponse:<\/i><\/b> This sentence is not part of a reference but instead the interpretation of our findings. We have clarified that by adding an introduction phase as follows: \u201c\nAccording to our findings, high blood pressure levels increased the risk of 10-year all-cause mortality, \u2026<\/i>\u201d","URL":"https:\/\/f1000research.com\/articles\/10-1134\/v1#referee-comment-9188","order":2,"name":"referee-comment-9188","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"RMC-L is supported by a Wellcome Trust International Training Fellowship, London, UK (214185\/Z\/18\/Z). AB-O (103994\/Z\/14\/Z) and JJM (074833\/Z\/04\/Z, 20517\/Z\/16\/Z) were supported by the Wellcome Trust, London, UK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]},{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T15:21:59Z","timestamp":1776957719689,"version":"3.51.4"},"reference-count":69,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["109916"],"award-info":[{"award-number":["109916"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["104648"],"award-info":[{"award-number":["104648"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["108504"],"award-info":[{"award-number":["108504"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["093853"],"award-info":[{"award-number":["093853"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["097383"],"award-info":[{"award-number":["097383"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["092076"],"award-info":[{"award-number":["092076"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["200885"],"award-info":[{"award-number":["200885"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"abstract":"Numerous links exist between co-transcriptional RNA processing and the transcribing RNAPII. In particular, pre-mRNA splicing was reported to be associated with slowed RNAPII elongation. Here, we identify a site of ubiquitination (K1246) in the catalytic subunit of RNAPII close to the DNA entry path. Ubiquitination was increased in the absence of the Bre5-Ubp3 ubiquitin protease complex. Bre5 binds RNA in vivo, with a preference for exon 2 regions of intron-containing pre-mRNAs and poly(A) proximal sites. Ubiquitinated RNAPII showed similar enrichment. The absence of Bre5 led to impaired splicing and defects in RNAPII elongation in vivo on a splicing reporter construct. Strains expressing RNAPII with a K1246R mutation showed reduced co-transcriptional splicing. We propose that ubiquinitation of RNAPII is induced by RNA processing events and linked to transcriptional pausing, which is released by Bre5-Ubp3 associated with the nascent transcript.<\/jats:p>","DOI":"10.7554\/elife.27082","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T08:00:24Z","timestamp":1507881624000},"source":"Crossref","is-referenced-by-count":20,"title":["RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit"],"prefix":"10.7554","volume":"6","author":[{"given":"Laura","family":"Milligan","sequence":"first","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8226-7272","authenticated-orcid":true,"given":"Camille","family":"Sayou","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Tuck","sequence":"additional","affiliation":[{"name":"Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsiana","family":"Auchynnikava","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane EA","family":"Reid","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Alexander","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia de Lima","family":"Alves","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Allshire","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Spanos","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juri","family":"Rappsilber","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland"},{"name":"Institute of Biotechnology, Technische Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean D","family":"Beggs","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Kudla","sequence":"additional","affiliation":[{"name":"MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2894-2772","authenticated-orcid":true,"given":"David","family":"Tollervey","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4374","published-online":{"date-parts":[[2017,10,13]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1261\/rna.2119903","article-title":"Identification and characterization of Prp45p and Prp46p, essential pre-mRNA splicing factors","volume":"9","author":"Albers","year":"2003","journal-title":"RNA"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1261\/rna.2162610","article-title":"RiboSys, a high-resolution, quantitative approach to measure the in vivo kinetics of pre-mRNA splicing and 3'-end processing in Saccharomyces cerevisiae","volume":"16","author":"Alexander","year":"2010","journal-title":"RNA"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.molcel.2010.11.005","article-title":"Splicing-dependent RNA polymerase pausing in yeast","volume":"40","author":"Alexander","year":"2010","journal-title":"Molecular Cell"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"W39","DOI":"10.1093\/nar\/gkv416","article-title":"The MEME Suite","volume":"43","author":"Bailey","year":"2015","journal-title":"Nucleic Acids Research"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"39067","DOI":"10.1074\/jbc.M508064200","article-title":"Atg19p ubiquitination and the cytoplasm to vacuole trafficking pathway in yeast","volume":"280","author":"Baxter","year":"2005","journal-title":"Journal of Biological Chemistry"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1002\/(SICI)1097-0061(19980915)14:12<1127::AID-YEA300>3.0.CO;2-#","article-title":"Functional analysis of yeast essential genes using a promoter-substitution cassette and the tetracycline-regulatable dual expression system","volume":"14","author":"Bell\u00ed","year":"1998","journal-title":"Yeast"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1016\/j.dnarep.2007.04.010","article-title":"The Bre5\/Ubp3 ubiquitin protease complex from budding yeast contributes to the cellular response to DNA damage","volume":"6","author":"Bilsland","year":"2007","journal-title":"DNA Repair"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.cell.2013.07.033","article-title":"From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II","volume":"154","author":"Braberg","year":"2013","journal-title":"Cell"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.molcel.2017.01.005","article-title":"Nuclear RNA Decay Pathways Aid Rapid Remodeling of Gene Expression in Yeast","volume":"65","author":"Bresson","year":"2017","journal-title":"Molecular Cell"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.molcel.2010.11.004","article-title":"Global analysis of nascent RNA reveals transcriptional pausing in terminal exons","volume":"40","author":"Carrillo Oesterreich","year":"2010","journal-title":"Molecular Cell"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.molcel.2014.01.017","article-title":"A splicing-dependent transcriptional checkpoint associated with prespliceosome formation","volume":"53","author":"Chathoth","year":"2014","journal-title":"Molecular Cell"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1042\/BJ20101152","article-title":"Transcriptional activation requires protection of the TATA-binding protein Tbp1 by the ubiquitin-specific protease Ubp3","volume":"431","author":"Chew","year":"2010","journal-title":"Biochemical Journal"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/nature09652","article-title":"Nascent transcript sequencing visualizes transcription at nucleotide resolution","volume":"469","author":"Churchman","year":"2011","journal-title":"Nature"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/ncb1003","article-title":"Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23","volume":"5","author":"Cohen","year":"2003","journal-title":"Nature Cell Biology"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/nature05649","article-title":"Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map","volume":"446","author":"Collins","year":"2007","journal-title":"Nature"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/nrm3956","article-title":"Orchestrating transcription with the Pol II CTD","volume":"16","author":"Conaway","year":"2015","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1126\/science.1180823","article-title":"The genetic landscape of a cell","volume":"327","author":"Costanzo","year":"2010","journal-title":"Science"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"5821","DOI":"10.1073\/pnas.0710533105","article-title":"Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles","volume":"105","author":"Decourty","year":"2008","journal-title":"PNAS"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"895","DOI":"10.3390\/biology1030895","article-title":"FLEXBAR-Flexible Barcode and Adapter Processing for Next-Generation Sequencing Platforms","volume":"1","author":"Dodt","year":"2012","journal-title":"Biology"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/abio.1993.1170","article-title":"Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins","volume":"210","author":"Frangioni","year":"1993","journal-title":"Analytical Biochemistry"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1038\/nmeth.3170","article-title":"A robust pipeline for rapid production of versatile nanobody repertoires","volume":"11","author":"Fridy","year":"2014","journal-title":"Nature Methods"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.jprot.2013.10.029","article-title":"Technical considerations for large-scale parallel reaction monitoring analysis","volume":"100","author":"Gallien","year":"2014","journal-title":"Journal of Proteomics"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"9613","DOI":"10.1073\/pnas.0901997106","article-title":"Identification of protein binding sites on U3 snoRNA and pre-rRNA by UV cross-linking and high-throughput analysis of cDNAs","volume":"106","author":"Granneman","year":"2009","journal-title":"PNAS"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"4006","DOI":"10.1038\/emboj.2011.256","article-title":"A cluster of ribosome synthesis factors regulate pre-rRNA folding and 5.8S rRNA maturation by the Rat1 exonuclease","volume":"30","author":"Granneman","year":"2011","journal-title":"The EMBO Journal"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"20705","DOI":"10.1073\/pnas.0907052106","article-title":"Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation","volume":"106","author":"Harreman","year":"2009","journal-title":"PNAS"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S1097-2765(03)00488-X","article-title":"Cytoplasmic degradation of splice-defective pre-mRNAs and intermediates","volume":"12","author":"Hilleren","year":"2003","journal-title":"Molecular Cell"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"e1005735","DOI":"10.1371\/journal.pgen.1005735","article-title":"Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough","volume":"11","author":"Holmes","year":"2015","journal-title":"PLOS Genetics"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/sj.embor.7400612","article-title":"Yeast Trf5p is a nuclear poly(A) polymerase","volume":"7","author":"Houseley","year":"2006","journal-title":"EMBO reports"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1101\/gad.200303.112","article-title":"The RNA polymerase II CTD coordinates transcription and RNA processing","volume":"26","author":"Hsin","year":"2012","journal-title":"Genes & Development"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0021-9673(02)01402-4","article-title":"Microcolumns with self-assembled particle frits for proteomics","volume":"979","author":"Ishihama","year":"2002","journal-title":"Journal of Chromatography A"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"e1002627","DOI":"10.1371\/journal.pgen.1002627","article-title":"Dissection of Pol II trigger loop function and Pol II activity-dependent control of start site selection in vivo","volume":"8","author":"Kaplan","year":"2012","journal-title":"PLoS Genetics"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/ncb1723","article-title":"Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p\/Bre5p ubiquitin protease","volume":"10","author":"Kraft","year":"2008","journal-title":"Nature Cell Biology"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.molcel.2008.04.018","article-title":"Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease Ubp3","volume":"30","author":"Kvint","year":"2008","journal-title":"Molecular Cell"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/nsmb.3000","article-title":"CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II-transcribed genes","volume":"22","author":"Laitem","year":"2015","journal-title":"Nature Structural & Molecular Biology"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"29176","DOI":"10.1074\/jbc.M502975200","article-title":"Structural basis for interaction between the Ubp3 deubiquitinating enzyme and its Bre5 cofactor","volume":"280","author":"Li","year":"2005","journal-title":"Journal of Biological Chemistry"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1093\/nar\/gkv005","article-title":"Interaction between the RNA-dependent ATPase and poly(A) polymerase subunits of the TRAMP complex is mediated by short peptides and important for snoRNA processing","volume":"43","author":"Losh","year":"2015","journal-title":"Nucleic Acids Research"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","article-title":"Skyline: an open source document editor for creating and analyzing targeted proteomics experiments","volume":"26","author":"MacLean","year":"2010","journal-title":"Bioinformatics"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.cell.2015.03.010","article-title":"Native elongating transcript sequencing reveals human transcriptional activity at nucleotide resolution","volume":"161","author":"Mayer","year":"2015","journal-title":"Cell"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"5446","DOI":"10.1128\/MCB.00463-08","article-title":"A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts","volume":"28","author":"Milligan","year":"2008","journal-title":"Molecular and Cellular Biology"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"874","DOI":"10.15252\/msb.20166869","article-title":"Strand-specific, high-resolution mapping of modified RNA polymerase II","volume":"12","author":"Milligan","year":"2016","journal-title":"Molecular Systems Biology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/nsmb.2468","article-title":"Global analysis of yeast mRNPs","volume":"20","author":"Mitchell","year":"2013","journal-title":"Nature Structural & Molecular Biology"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/S0092-8674(00)80139-7","article-title":"A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae","volume":"86","author":"Moazed","year":"1996","journal-title":"Cell"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1146\/annurev-biochem-060614-034242","article-title":"Regulation of alternative splicing through coupling with transcription and chromatin structure","volume":"84","author":"Naftelberg","year":"2015","journal-title":"Annual Review of Biochemistry"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1038\/sj.embor.7400026","article-title":"Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p","volume":"4","author":"Neumann","year":"2003","journal-title":"EMBO Reports"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.cell.2015.03.027","article-title":"Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing","volume":"161","author":"Nojima","year":"2015","journal-title":"Cell"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1101\/gad.285604","article-title":"A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits","volume":"18","author":"Oeffinger","year":"2004","journal-title":"Genes & Development"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.1016\/j.yexcr.2010.09.005","article-title":"The Rsp5 ubiquitin ligase and the AAA-ATPase Cdc48 control the ubiquitin-mediated degradation of the COPII component Sec23","volume":"316","author":"Ossareh-Nazari","year":"2010","journal-title":"Experimental Cell Research"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/nrm3943","article-title":"Transcription termination and the control of the transcriptome: why, where and how to stop","volume":"16","author":"Porrua","year":"2015","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1021\/ac026117i","article-title":"Stop and go extraction tips for matrix-assisted laser desorption\/ionization, nanoelectrospray, and LC\/MS sample pretreatment in proteomics","volume":"75","author":"Rappsilber","year":"2003","journal-title":"Analytical Chemistry"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1038\/13732","article-title":"A generic protein purification method for protein complex characterization and proteome exploration","volume":"17","author":"Rigaut","year":"1999","journal-title":"Nature Biotechnology"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nature11715","article-title":"Structure and function of the initially transcribing RNA polymerase II-TFIIB complex","volume":"493","author":"Sainsbury","year":"2013","journal-title":"Nature"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1016\/j.jmb.2016.04.017","article-title":"Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing","volume":"428","author":"Saldi","year":"2016","journal-title":"Journal of Molecular Biology"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"e00165-17","DOI":"10.1128\/MCB.00165-17","article-title":"RNA binding by histone methyltransferases Set1 and Set2","volume":"37","author":"Sayou","year":"2017","journal-title":"Molecular and Cellular Biology"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/yea.2898","article-title":"Genetic interactions of yeast NEP1 (EMG1), encoding an essential factor in ribosome biogenesis","volume":"29","author":"Schilling","year":"2012","journal-title":"Yeast"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.molcel.2012.08.013","article-title":"Transcriptome-wide analysis of exosome targets","volume":"48","author":"Schneider","year":"2012","journal-title":"Molecular Cell"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.15252\/embj.201488757","article-title":"The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase","volume":"33","author":"Schuch","year":"2014","journal-title":"The EMBO Journal"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1021\/ac950914h","article-title":"Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels","volume":"68","author":"Shevchenko","year":"1996","journal-title":"Analytical Chemistry"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.cell.2007.01.046","article-title":"Communication between distant sites in RNA polymerase II through ubiquitylation factors and the polymerase CTD","volume":"129","author":"Somesh","year":"2007","journal-title":"Cell"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1101\/gad.1925010","article-title":"The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome","volume":"24","author":"Song","year":"2010","journal-title":"Genes & Development"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"31816","DOI":"10.1074\/jbc.M113.491290","article-title":"Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger ribonucleoprotein particle (mRNP) in yeast","volume":"288","author":"Stuparevic","year":"2013","journal-title":"Journal of Biological Chemistry"},{"key":"bib64","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1002\/j.1460-2075.1987.tb02763.x","article-title":"A yeast small nuclear RNA is required for normal processing of pre-ribosomal RNA","volume":"6","author":"Tollervey","year":"1987","journal-title":"The EMBO Journal"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.cell.2013.07.047","article-title":"A transcriptome-wide atlas of RNP composition reveals diverse classes of mRNAs and lncRNAs","volume":"154","author":"Tuck","year":"2013","journal-title":"Cell"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"R8","DOI":"10.1186\/gb-2014-15-1-r8","article-title":"PAR-CLIP data indicate that Nrd1-Nab3-dependent transcription termination regulates expression of hundreds of protein coding genes in yeast","volume":"15","author":"Webb","year":"2014","journal-title":"Genome Biology"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"e46398","DOI":"10.1371\/journal.pone.0046398","article-title":"MultiDsk: a ubiquitin-specific affinity resin","volume":"7","author":"Wilson","year":"2012","journal-title":"PLoS One"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"Wi\u015bniewski","year":"2009","journal-title":"Nature Methods"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/nature07728","article-title":"Bidirectional promoters generate pervasive transcription in yeast","volume":"457","author":"Xu","year":"2009","journal-title":"Nature"}],"container-title":["eLife"],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/27082\/elife-27082-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/27082\/elife-27082-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/27082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:55:55Z","timestamp":1697057755000},"score":9.742465,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/27082"}},"issued":{"date-parts":[[2017,10,13]]},"references-count":69,"aliases":["10.7554\/elife.27082.034","10.7554\/elife.27082.031"],"alternative-id":["10.7554\/eLife.27082"],"URL":"https:\/\/doi.org\/10.7554\/elife.27082","archive":["CLOCKSS"],"relation":{"is-supplemented-by":[{"id-type":"uri","id":"https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE94944","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.27082.033","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.27082.032","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"published":{"date-parts":[[2017,10,13]]},"article-number":"e27082"},{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:45:02Z","timestamp":1779403502057,"version":"3.53.1"},"reference-count":193,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["226014"],"award-info":[{"award-number":["226014"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["224315"],"award-info":[{"award-number":["224315"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["107769"],"award-info":[{"award-number":["107769"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["203077"],"award-info":[{"award-number":["203077"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"Severe anaemia and invasive bacterial infections remain important causes of hospitalization and death among young African children. The emergence and spread of antimicrobial resistance demand better understanding of bacteraemia risk factors to inform prevention strategies. Epidemiological studies have reported an association between severe anaemia and bacteraemia. In this review, we explore evidence that severe anaemia is associated with increased risk of invasive bacterial infections in young children. We describe mechanisms of iron dysregulation in severe anaemia that might contribute to increased risk and pathogenesis of invasive bacteria, recent advances in knowledge of how iron deficiency and severe anaemia impair immune responses to bacterial infections and vaccines, and the gaps in our understanding of mechanisms underlying severe anaemia, iron deficiency, and the risk of invasive bacterial infections.<\/ns3:p>","DOI":"10.12688\/wellcomeopenres.18829.1","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T08:09:56Z","timestamp":1675325396000},"page":"48","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Severe anaemia, iron deficiency, and susceptibility to invasive bacterial infections"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5726-1776","authenticated-orcid":false,"given":"Kelvin M.","family":"Abuga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Nairz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9694-0846","authenticated-orcid":false,"given":"Calman A.","family":"MacLennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8360-4402","authenticated-orcid":false,"given":"Sarah H.","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"417-32","DOI":"10.1016\/S1473-3099(10)70072-4","article-title":"Community-acquired bloodstream infections in Africa: a systematic review and meta-analysis.","volume":"10","author":"E Reddy","year":"2010","journal-title":"Lancet Infect Dis."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"39-47","DOI":"10.1056\/NEJMoa040275","article-title":"Bacteremia among children admitted to a rural hospital in Kenya.","volume":"352","author":"J Berkley","year":"2005","journal-title":"N Engl J Med."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"108-13","DOI":"10.1097\/INF.0b013e318187a87d","article-title":"Community-acquired bacteremia among children admitted to a rural hospital in Mozambique.","volume":"28","author":"B Siga\u00faque","year":"2009","journal-title":"Pediatr Infect Dis J."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"180-8","DOI":"10.1016\/s1201-9712(01)90067-0","article-title":"Community-acquired bacteremia among hospitalized children in rural central Africa.","volume":"5","author":"P Bahwere","year":"2001","journal-title":"Int J Infect Dis."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"c1350","DOI":"10.1136\/bmj.c1350","article-title":"WHO guidelines for antimicrobial treatment in children admitted to hospital in an area of intense Plasmodium falciparum transmission: prospective study.","volume":"340","author":"B Nadjm","year":"2010","journal-title":"BMJ."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"e023445","DOI":"10.1136\/bmjopen-2018-023445","article-title":"Paediatric postdischarge mortality in developing countries: a systematic review.","volume":"8","author":"B Nemetchek","year":"2018","journal-title":"BMJ Open."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"482-8","DOI":"10.1016\/S0140-6736(06)68180-4","article-title":"Incidence of clinically significant bacteraemia in children who present to hospital in Kenya: community-based observational study.","volume":"367","author":"A Brent","year":"2006","journal-title":"Lancet."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1741-7015-12-31","article-title":"Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review.","volume":"12","author":"J Church","year":"2014","journal-title":"BMC Med."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"1364-70","DOI":"10.1016\/S0140-6736(09)61374-X","article-title":"Bacteraemia in Kenyan children with sickle-cell anaemia: a retrospective cohort and case-control study.","volume":"374","author":"T Williams","year":"2009","journal-title":"Lancet."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/1471-2334-6-160","article-title":"Bacteraemia among severely malnourished children infected and uninfected with the human immunodeficiency virus-1 in Kampala, Uganda.","volume":"6","author":"H Bachou","year":"2006","journal-title":"BMC Infect Dis."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"690-5","DOI":"10.1111\/j.1365-2141.2011.08761.x","article-title":"Severe acquired anaemia in Africa: new concepts.","volume":"154","author":"M van Hensbroek","year":"2011","journal-title":"Br J Haematol."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"e1435-e1447","DOI":"10.1016\/S2214-109X(19)30345-6","article-title":"Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial.","volume":"7","author":"K Maitland","year":"2019","journal-title":"Lancet Glob Health."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"474-83","DOI":"10.1016\/S2352-4642(22)00074-8","article-title":"Post-discharge morbidity and mortality in children admitted with severe anaemia and other health conditions in malaria-endemic settings in Africa: a systematic review and meta-analysis.","volume":"6","author":"T Kwambai","year":"2022","journal-title":"Lancet Child Adolesc Health."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"e2903","DOI":"10.1371\/journal.pone.0002903","article-title":"Long term outcome of severe anaemia in Malawian children.","volume":"3","author":"K Phiri","year":"2008","journal-title":"PLoS One."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"e16-25","DOI":"10.1016\/S2214-109X(13)70001-9","article-title":"Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995-2011: a systematic analysis of population-representative data.","volume":"1","author":"G Stevens","year":"2013","journal-title":"Lancet Glob Health."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"459-68","DOI":"10.2471\/BLT.10.083568","article-title":"Spatial heterogeneity of haemoglobin concentration in preschool-age children in sub-Saharan Africa.","volume":"89","author":"R Soares Magalh\u00e3es","year":"2011","journal-title":"Bull World Health Organ."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"247-308","DOI":"10.1016\/j.hoc.2015.11.002","article-title":"The Global Burden of Anemia.","volume":"30","author":"N Kassebaum","year":"2016","journal-title":"Hematol Oncol Clin North Am."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"888-99","DOI":"10.1056\/NEJMoa072727","article-title":"Severe anemia in Malawian children.","volume":"358","author":"J Calis","year":"2008","journal-title":"N Engl J Med."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"165-78","DOI":"10.1046\/j.1365-3156.1997.d01-238.x","article-title":"Severe anaemia in children living in a malaria endemic area of Kenya.","volume":"2","author":"C Newton","year":"1997","journal-title":"Trop Med Int Health."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1186\/1475-2875-9-307","article-title":"Changing trends in blood transfusion in children and neonates admitted in Kilifi District Hospital, Kenya.","volume":"9","author":"R Pedro","year":"2010","journal-title":"Malar J."},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12878-015-0033-5","article-title":"Prevalence and factors associated with severe anaemia amongst under-five children hospitalized at Bugando Medical Centre, Mwanza, Tanzania.","volume":"15","author":"R Simbauranga","year":"2015","journal-title":"BMC Hematol."},{"key":"ref-22","doi-asserted-by":"publisher","first-page":"655-60","DOI":"10.4269\/ajtmh.1996.55.655","article-title":"Childhood mortality during and after hospitalization in western Kenya: effect of malaria treatment regimens.","volume":"55","author":"J Zucker","year":"1996","journal-title":"Am J Trop Med Hyg."},{"key":"ref-23","article-title":"Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity","year":"2011"},{"key":"ref-24","doi-asserted-by":"publisher","first-page":"104-107","DOI":"10.1038\/s41586-019-1151-1","article-title":"Synthesis and breakdown of universal metabolic precursors promoted by iron.","volume":"569","author":"K Muchowska","year":"2019","journal-title":"Nature."},{"key":"ref-25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/fphys.2014.00003","article-title":"Primitive and definitive erythropoiesis in mammals.","volume":"5","author":"J Palis","year":"2014","journal-title":"Front Physiol."},{"key":"ref-26","doi-asserted-by":"publisher","first-page":"e0122139","DOI":"10.1371\/journal.pone.0122139","article-title":"Clinical indicators for bacterial co-infection in Ghanaian children with P. falciparum infection.","volume":"10","author":"M Nielsen","year":"2015","journal-title":"PLoS One."},{"key":"ref-27","doi-asserted-by":"publisher","first-page":"671-6","DOI":"10.1128\/JCM.01864-10","article-title":"Bacteremia in Kenyan children presenting with malaria.","volume":"49","author":"T Were","year":"2011","journal-title":"J Clin Microbiol."},{"key":"ref-28","first-page":"146-50","article-title":"Malaria with bacteraemia in acutely febrile preschool children without localizing signs: coincidence or association\/complication?","volume":"96","author":"G Akpede","year":"1993","journal-title":"J Trop Med Hyg."},{"key":"ref-29","doi-asserted-by":"publisher","first-page":"2574-2580","DOI":"10.4269\/ajtmh.20-0199","article-title":"Severe Anemia Is Associated with Systemic Inflammation in Young Children Presenting to a Tertiary Hospital in Uganda.","volume":"103","author":"R Opoka","year":"2020","journal-title":"Am J Trop Med Hyg."},{"key":"ref-30","doi-asserted-by":"publisher","first-page":"945-51","DOI":"10.1038\/nm.4146","article-title":"On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver.","volume":"22","author":"I Theurl","year":"2016","journal-title":"Nat Med."},{"key":"ref-31","doi-asserted-by":"publisher","first-page":"1223-1234","DOI":"10.1016\/j.cell.2014.01.069","article-title":"Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.","volume":"156","author":"M Haldar","year":"2014","journal-title":"Cell."},{"key":"ref-32","first-page":"27-34","article-title":"Absorption of heme iron.","volume":"35","author":"C Uzel","year":"1998","journal-title":"Semin Hematol."},{"key":"ref-33","doi-asserted-by":"publisher","first-page":"1755-9","DOI":"10.1126\/science.1057206","article-title":"An iron-regulated ferric reductase associated with the absorption of dietary iron.","volume":"291","author":"A McKie","year":"2001","journal-title":"Science."},{"key":"ref-34","doi-asserted-by":"publisher","first-page":"482-8","DOI":"10.1038\/41343","article-title":"Cloning and characterization of a mammalian proton-coupled metal-ion transporter.","volume":"388","author":"H Gunshin","year":"1997","journal-title":"Nature."},{"key":"ref-35","doi-asserted-by":"publisher","first-page":"776-81","DOI":"10.1038\/35001596","article-title":"Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter.","volume":"403","author":"A Donovan","year":"2000","journal-title":"Nature."},{"key":"ref-36","doi-asserted-by":"publisher","first-page":"2090-3","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.","volume":"306","author":"E Nemeth","year":"2004","journal-title":"Science."},{"key":"ref-37","doi-asserted-by":"publisher","first-page":"195-9","DOI":"10.1038\/5979","article-title":"Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse.","volume":"21","author":"C Vulpe","year":"1999","journal-title":"Nat Genet."},{"key":"ref-38","doi-asserted-by":"publisher","first-page":"322-32","DOI":"10.1007\/s12291-012-0250-7","article-title":"Non transferrin bound iron: nature, manifestations and analytical approaches for estimation.","volume":"27","author":"M Patel","year":"2012","journal-title":"Indian J Clin Biochem."},{"key":"ref-39","doi-asserted-by":"publisher","first-page":"69-74","DOI":"10.1016\/j.freeradbiomed.2018.07.003","article-title":"Erythropoietic regulators of iron metabolism.","volume":"133","author":"T Ganz","year":"2019","journal-title":"Free Radic Biol Med."},{"key":"ref-40","doi-asserted-by":"publisher","first-page":"410-6","DOI":"10.1111\/j.1749-6632.1959.tb36917.x","article-title":"Some quantitative aspects of erythropoiesis.","volume":"77","author":"C Finch","year":"1959","journal-title":"Ann N Y Acad Sci."},{"key":"ref-41","doi-asserted-by":"publisher","first-page":"678-84","DOI":"10.1038\/ng.2996","article-title":"Identification of erythroferrone as an erythroid regulator of iron metabolism.","volume":"46","author":"L Kautz","year":"2014","journal-title":"Nat Genet."},{"key":"ref-42","doi-asserted-by":"publisher","first-page":"1037-1044","DOI":"10.1172\/JCI15686","article-title":"The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation.","volume":"110","author":"G Nicolas","year":"2002","journal-title":"J Clin Invest."},{"key":"ref-43","doi-asserted-by":"publisher","first-page":"1951-9","DOI":"10.1136\/gutjnl-2013-305317","article-title":"Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB.","volume":"63","author":"T Sonnweber","year":"2014","journal-title":"Gut."},{"key":"ref-44","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.3389\/fphys.2019.01294","article-title":"Hepcidin and Anemia: A Tight Relationship.","volume":"10","author":"A Pagani","year":"2019","journal-title":"Front Physiol."},{"key":"ref-45","doi-asserted-by":"publisher","first-page":"e78964","DOI":"10.1371\/journal.pone.0078964","article-title":"Low hepcidin levels in severely anemic malawian children with high incidence of infectious diseases and bone marrow iron deficiency.","volume":"8","author":"F Jonker","year":"2013","journal-title":"PLoS One."},{"key":"ref-46","doi-asserted-by":"publisher","first-page":"1589-1598","DOI":"10.3324\/haematol.2021.279316","article-title":"Hepcidin regulation in Kenyan children with severe malaria and non-typhoidal Salmonella bacteremia.","volume":"107","author":"K Abuga","year":"2022","journal-title":"Haematologica."},{"key":"ref-47","doi-asserted-by":"publisher","first-page":"158-164","DOI":"10.1016\/j.ebiom.2018.07.024","article-title":"Decreased Hepcidin Levels Are Associated with Low Steady-state Hemoglobin in Children With Sickle Cell Disease in Tanzania.","volume":"34","author":"N Lee","year":"2018","journal-title":"EBioMedicine."},{"key":"ref-48","doi-asserted-by":"publisher","first-page":"133-43","DOI":"10.1016\/S0140-6736(06)67962-2","article-title":"Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial.","volume":"367","author":"S Sazawal","year":"2006","journal-title":"Lancet."},{"key":"ref-49","doi-asserted-by":"publisher","first-page":"492-504","DOI":"10.1016\/j.immuni.2016.02.016","article-title":"Macrophages and Iron Metabolism.","volume":"44","author":"M Soares","year":"2016","journal-title":"Immunity."},{"key":"ref-50","doi-asserted-by":"publisher","first-page":"1276-84","DOI":"10.1182\/blood-2012-11-451229","article-title":"Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins.","volume":"121","author":"D Schaer","year":"2013","journal-title":"Blood."},{"key":"ref-51","doi-asserted-by":"publisher","first-page":"1807-1814","DOI":"10.1093\/cid\/ciy791","article-title":"Iron Status and Associated Malaria Risk Among African Children.","volume":"68","author":"J Muriuki","year":"2019","journal-title":"Clin Infect Dis."},{"key":"ref-52","doi-asserted-by":"publisher","first-page":"e42670","DOI":"10.1371\/journal.pone.0042670","article-title":"Iron status predicts malaria risk in Malawian preschool children.","volume":"7","author":"F Jonker","year":"2012","journal-title":"PLoS One."},{"key":"ref-53","doi-asserted-by":"publisher","first-page":"731-42","DOI":"10.1136\/gutjnl-2014-307720","article-title":"Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants.","volume":"64","author":"T Jaeggi","year":"2015","journal-title":"Gut."},{"key":"ref-54","doi-asserted-by":"publisher","first-page":"e2133935","DOI":"10.1001\/jamanetworkopen.2021.33935","article-title":"Risk of Infection Associated With Administration of Intravenous Iron: A Systematic Review and Meta-analysis.","volume":"4","author":"A Shah","year":"2021","journal-title":"JAMA Netw Open."},{"key":"ref-55","doi-asserted-by":"publisher","first-page":"63-7","DOI":"10.1016\/j.coi.2009.01.011","article-title":"Iron in innate immunity: starve the invaders.","volume":"21","author":"T Ganz","year":"2009","journal-title":"Curr Opin Immunol."},{"key":"ref-56","doi-asserted-by":"publisher","first-page":"e1000949","DOI":"10.1371\/journal.ppat.1000949","article-title":"The battle for iron between bacterial pathogens and their vertebrate hosts.","volume":"6","author":"E Skaar","year":"2010","journal-title":"PLoS Pathog."},{"key":"ref-57","doi-asserted-by":"publisher","first-page":"525-37","DOI":"10.1038\/nrmicro2836","article-title":"Nutritional immunity: transition metals at the pathogen-host interface.","volume":"10","author":"M Hood","year":"2012","journal-title":"Nat Rev Microbiol."},{"key":"ref-58","doi-asserted-by":"publisher","first-page":"e00253-18","DOI":"10.1128\/IAI.00253-18","article-title":"Hepcidin Protects against Lethal Escherichia coli Sepsis in Mice Inoculated with Isolates from Septic Patients.","volume":"86","author":"D Stefanova","year":"2018","journal-title":"Infect Immun."},{"key":"ref-59","doi-asserted-by":"publisher","first-page":"245-257","DOI":"10.1182\/blood-2017-03-772715","article-title":"Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron.","volume":"130","author":"D Stefanova","year":"2017","journal-title":"Blood."},{"key":"ref-60","doi-asserted-by":"publisher","first-page":"e92002","DOI":"10.1172\/jci.insight.92002","article-title":"Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia.","volume":"2","author":"K Michels","year":"2017","journal-title":"JCI Insight."},{"key":"ref-61","doi-asserted-by":"publisher","first-page":"335-7","DOI":"10.1038\/nm.3526","article-title":"Hypoferremia of infection: a double-edged sword?","volume":"20","author":"K Lokken","year":"2014","journal-title":"Nat Med."},{"key":"ref-62","doi-asserted-by":"publisher","first-page":"40-50","DOI":"10.1182\/blood-2018-06-856500","article-title":"Anemia of inflammation.","volume":"133","author":"G Weiss","year":"2019","journal-title":"Blood."},{"key":"ref-63","doi-asserted-by":"publisher","first-page":"4038-44","DOI":"10.1182\/blood-2006-10-051755","article-title":"Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation.","volume":"109","author":"C Roy","year":"2007","journal-title":"Blood."},{"key":"ref-64","doi-asserted-by":"publisher","first-page":"eaaw9522","DOI":"10.1126\/scitranslmed.aaw9522","article-title":"Immune system development varies according to age, location, and anemia in African children.","volume":"12","author":"D Hill","year":"2020","journal-title":"Sci Transl Med."},{"key":"ref-65","doi-asserted-by":"publisher","first-page":"6976","DOI":"10.3390\/ijms21186976","article-title":"How Severe Anaemia Might Influence the Risk of Invasive Bacterial Infections in African Children.","volume":"21","author":"K Abuga","year":"2020","journal-title":"Int J Mol Sci."},{"key":"ref-66","doi-asserted-by":"publisher","first-page":"G705-G716","DOI":"10.1152\/ajpgi.00324.2019","article-title":"Severe neonatal anemia increases intestinal permeability by disrupting epithelial adherens junctions.","volume":"318","author":"K MohanKumar","year":"2020","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"ref-67","doi-asserted-by":"publisher","first-page":"1233-1245","DOI":"10.1111\/trf.15254","article-title":"Anemia induces gut inflammation and injury in an animal model of preterm infants.","volume":"59","author":"C Arthur","year":"2019","journal-title":"Transfusion."},{"key":"ref-68","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/1471-2334-13-117","article-title":"Endotoxaemia is common in children with Plasmodium falciparum malaria.","volume":"13","author":"P Olupot-Olupot","year":"2013","journal-title":"BMC Infect Dis."},{"key":"ref-69","doi-asserted-by":"publisher","first-page":"e1002833","DOI":"10.1371\/journal.pmed.1002833","article-title":"Associations of genetically determined iron status across the phenome: A mendelian randomization study.","volume":"16","author":"D Gill","year":"2019","journal-title":"PLoS Med."},{"key":"ref-70","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.3389\/fimmu.2020.01221","article-title":"The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria.","volume":"11","author":"D Kell","year":"2020","journal-title":"Front Immunol."},{"key":"ref-71","doi-asserted-by":"publisher","first-page":"103-130","DOI":"10.1146\/annurev-nutr-071816-064559","article-title":"Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation.","volume":"37","author":"X Xiao","year":"2017","journal-title":"Annu Rev Nutr."},{"key":"ref-72","doi-asserted-by":"publisher","first-page":"182-203","DOI":"10.1111\/imr.12266","article-title":"Macrophage defense mechanisms against intracellular bacteria.","volume":"264","author":"G Weiss","year":"2015","journal-title":"Immunol Rev."},{"key":"ref-73","doi-asserted-by":"publisher","first-page":"3727-32","DOI":"10.1182\/blood-2005-06-2259","article-title":"TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens.","volume":"107","author":"C Peyssonnaux","year":"2006","journal-title":"Blood."},{"key":"ref-74","doi-asserted-by":"publisher","first-page":"3322-8","DOI":"10.1172\/JCI39939","article-title":"Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice.","volume":"119","author":"L Wang","year":"2009","journal-title":"J Clin Invest."},{"key":"ref-75","doi-asserted-by":"publisher","first-page":"eabq4469","DOI":"10.1126\/sciadv.abq4469","article-title":"Iron regulatory protein (IRP)-mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow.","volume":"8","author":"M Bonadonna","year":"2022","journal-title":"Sci Adv."},{"key":"ref-76","doi-asserted-by":"publisher","first-page":"eabq5384","DOI":"10.1126\/sciadv.abq5384","article-title":"Plasma iron controls neutrophil production and function.","volume":"8","author":"J Frost","year":"2022","journal-title":"Sci Adv."},{"key":"ref-77","doi-asserted-by":"publisher","first-page":"120-7","DOI":"10.1038\/nm.2601","article-title":"Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization.","volume":"18","author":"A Cunnington","year":"2011","journal-title":"Nat Med."},{"key":"ref-78","doi-asserted-by":"publisher","first-page":"1520-7","DOI":"10.1128\/IAI.00887-09","article-title":"Both hemolytic anemia and malaria parasite-specific factors increase susceptibility to Nontyphoidal Salmonella enterica serovar typhimurium infection in mice.","volume":"78","author":"C Roux","year":"2010","journal-title":"Infect Immun."},{"key":"ref-79","doi-asserted-by":"publisher","first-page":"1302-11","DOI":"10.1038\/mi.2014.18","article-title":"The mucosal inflammatory response to non-typhoidal Salmonella in the intestine is blunted by IL-10 during concurrent malaria parasite infection.","volume":"7","author":"J Mooney","year":"2014","journal-title":"Mucosal Immunol."},{"key":"ref-80","doi-asserted-by":"publisher","first-page":"e1004049","DOI":"10.1371\/journal.ppat.1004049","article-title":"Malaria parasite infection compromises control of concurrent systemic non-typhoidal Salmonella infection via IL-10-mediated alteration of myeloid cell function.","volume":"10","author":"K Lokken","year":"2014","journal-title":"PLoS Pathog."},{"key":"ref-81","doi-asserted-by":"publisher","first-page":"e8899","DOI":"10.7759\/cureus.8899","article-title":"Iron Deficiency Anemia-Induced Neutropenia in Adult Female.","volume":"12","author":"E Abdelmahmuod","year":"2020","journal-title":"Cureus."},{"key":"ref-82","doi-asserted-by":"publisher","first-page":"512-5","DOI":"10.1046\/j.1365-2141.1999.01756.x","article-title":"Neutrophil hypersegmentation in iron deficiency anaemia: a case-control study.","volume":"107","author":"D Westerman","year":"1999","journal-title":"Br J Haematol."},{"key":"ref-83","doi-asserted-by":"publisher","first-page":"235-8","DOI":"10.1080\/08880010252899398","article-title":"Neutrophil hypersegmentation in children with iron deficiency anemia.","volume":"19","author":"T Sipahi","year":"2002","journal-title":"Pediatr Hematol Oncol."},{"key":"ref-84","doi-asserted-by":"publisher","first-page":"1464-8","DOI":"10.1182\/BLOOD.V69.5.1464.1464","article-title":"Iron deficiency and neutrophil function: different rates of correction of the depressions in oxidative burst and myeloperoxidase activity after iron treatment.","volume":"69","author":"H Murakawa","year":"1987","journal-title":"Blood."},{"key":"ref-85","doi-asserted-by":"publisher","first-page":"e00333","DOI":"10.1042\/BSR20160031","article-title":"Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils.","volume":"36","author":"L V\u00f6llger","year":"2016","journal-title":"Biosci Rep."},{"key":"ref-86","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1182\/blood.V128.22.161.161","article-title":"Free iron in sera of patients with sickle cell disease contributes to the release of neutrophil extracellular traps.","volume":"128","author":"K Van Avondt","year":"2016","journal-title":"Blood."},{"key":"ref-87","doi-asserted-by":"publisher","first-page":"118-22","DOI":"10.1016\/s0163-4453(84)92414-9","article-title":"Defective phagocytic and bactericidal function of polymorphonuclear leucocytes in patients with beta-thalassaemia major.","volume":"8","author":"A Skoutelis","year":"1984","journal-title":"J Infect."},{"key":"ref-88","doi-asserted-by":"publisher","first-page":"3853-3863","DOI":"10.1182\/bloodadvances.2020002198","article-title":"Neutrophils from hereditary hemochromatosis patients are protected from iron excess and are primed.","volume":"4","author":"C Renassia","year":"2020","journal-title":"Blood Adv."},{"key":"ref-89","doi-asserted-by":"publisher","first-page":"15602-7","DOI":"10.1073\/pnas.242614699","article-title":"The hemochromatosis protein HFE inhibits iron export from macrophages.","volume":"99","author":"H Drakesmith","year":"2002","journal-title":"Proc Natl Acad Sci U S A."},{"key":"ref-90","doi-asserted-by":"publisher","first-page":"1125-9","DOI":"10.1182\/blood.V96.3.1125","article-title":"Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis.","volume":"96","author":"G Montosi","year":"2000","journal-title":"Blood."},{"key":"ref-91","doi-asserted-by":"publisher","first-page":"e39363","DOI":"10.1371\/journal.pone.0039363","article-title":"Hfe deficiency impairs pulmonary neutrophil recruitment in response to inflammation.","volume":"7","author":"K Benesova","year":"2012","journal-title":"PLoS One."},{"key":"ref-92","doi-asserted-by":"publisher","first-page":"824-35","DOI":"10.1002\/eji.200939889","article-title":"Differential regulation of iron homeostasis during human macrophage polarized activation.","volume":"40","author":"S Recalcati","year":"2010","journal-title":"Eur J Immunol."},{"key":"ref-93","doi-asserted-by":"publisher","first-page":"473-86","DOI":"10.1182\/blood-2015-08-663245","article-title":"Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.","volume":"127","author":"F Vinchi","year":"2016","journal-title":"Blood."},{"key":"ref-94","doi-asserted-by":"publisher","first-page":"e02638-16","DOI":"10.1128\/AAC.02638-16","article-title":"Synthetic Porcine Hepcidin Exhibits Different Roles in Escherichia coli and Salmonella Infections.","volume":"61","author":"D Liu","year":"2017","journal-title":"Antimicrob Agents Chemother."},{"key":"ref-95","doi-asserted-by":"publisher","first-page":"e00353-17","DOI":"10.1128\/IAI.00353-17","article-title":"Hepcidin-(In)dependent Mechanisms of Iron Metabolism Regulation during Infection by Listeria and Salmonella.","volume":"85","author":"A Moreira","year":"2017","journal-title":"Infect Immun."},{"key":"ref-96","doi-asserted-by":"publisher","first-page":"2126-40","DOI":"10.1111\/j.1462-5822.2007.00942.x","article-title":"The co-ordinated regulation of iron homeostasis in murine macrophages limits the availability of iron for intracellular Salmonella typhimurium.","volume":"9","author":"M Nairz","year":"2007","journal-title":"Cell Microbiol."},{"key":"ref-97","doi-asserted-by":"publisher","first-page":"498-511.e5","DOI":"10.1016\/j.celrep.2019.06.039","article-title":"Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo.","volume":"28","author":"M Pereira","year":"2019","journal-title":"Cell Rep."},{"key":"ref-98","doi-asserted-by":"publisher","first-page":"727-34","DOI":"10.1046\/j.1365-2141.2002.03498.x","article-title":"Differentiation of functional dendritic cells and macrophages from human peripheral blood monocyte precursors is dependent on expression of p21 (WAF1\/CIP1) and requires iron.","volume":"117","author":"J Kramer","year":"2002","journal-title":"Br J Haematol."},{"key":"ref-99","doi-asserted-by":"publisher","first-page":"2048-55","DOI":"10.1016\/j.celrep.2015.11.005","article-title":"Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1\u03b1 upon LPS Activation in the Presence of Ample Oxygen.","volume":"13","author":"I Siegert","year":"2015","journal-title":"Cell Rep."},{"key":"ref-100","doi-asserted-by":"publisher","first-page":"1450-1465","DOI":"10.1038\/s41418-022-00932-1","article-title":"Heme-stress activated NRF2 skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages in hemolytic anemia.","volume":"29","author":"F Vallelian","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref-101","doi-asserted-by":"publisher","first-page":"186-189","DOI":"10.1126\/science.aau6481","article-title":"Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing.","volume":"368","author":"N Bessman","year":"2020","journal-title":"Science."},{"key":"ref-102","doi-asserted-by":"publisher","first-page":"455-464","DOI":"10.1159\/000491439","article-title":"Complement and Bacterial Infections: From Molecular Mechanisms to Therapeutic Applications.","volume":"10","author":"D Heesterbeek","year":"2018","journal-title":"J Innate Immun."},{"key":"ref-103","doi-asserted-by":"publisher","first-page":"799-811","DOI":"10.1016\/j.tim.2015.09.006","article-title":"Pentraxins and Collectins: Friend or Foe during Pathogen Invasion?","volume":"23","author":"S Foo","year":"2015","journal-title":"Trends Microbiol."},{"key":"ref-104","doi-asserted-by":"publisher","first-page":"2482-2488","DOI":"10.1007\/s12011-020-02379-2","article-title":"Serum Iron and Ferritin Levels Are Correlated with Complement C3.","volume":"199","author":"S Wen","year":"2021","journal-title":"Biol Trace Elem Res."},{"key":"ref-105","doi-asserted-by":"publisher","first-page":"899-902","DOI":"10.1016\/s0022-3476(75)80221-6","article-title":"Impaired immunocompetence associated with iron deficiency.","volume":"86","author":"R Chandra","year":"1975","journal-title":"J Pediatr."},{"key":"ref-106","doi-asserted-by":"publisher","first-page":"164-179.e12","DOI":"10.1016\/j.medj.2020.10.004","article-title":"Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection.","volume":"2","author":"J Frost","year":"2021","journal-title":"Med (N Y)."},{"key":"ref-107","doi-asserted-by":"publisher","first-page":"218-30","DOI":"10.1016\/0008-8749(89)90162-7","article-title":"Inhibition of lymphocyte activation with anti-transferrin receptor Mabs: a comparison of three reagents and further studies of their range of effects and mechanism of action.","volume":"122","author":"J Kemp","year":"1989","journal-title":"Cell Immunol."},{"key":"ref-108","doi-asserted-by":"publisher","first-page":"80-92.e7","DOI":"10.1016\/j.immuni.2018.05.008","article-title":"Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production.","volume":"49","author":"Z Wang","year":"2018","journal-title":"Immunity."},{"key":"ref-109","doi-asserted-by":"publisher","first-page":"3711-8","DOI":"10.1182\/blood-2003-04-1086","article-title":"Transferrin receptor 1 is differentially required in lymphocyte development.","volume":"102","author":"R Ned","year":"2003","journal-title":"Blood."},{"key":"ref-110","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1038\/s41467-019-11002-5","article-title":"Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses.","volume":"10","author":"Y Jiang","year":"2019","journal-title":"Nat Commun."},{"key":"ref-111","doi-asserted-by":"publisher","first-page":"74-8","DOI":"10.1038\/ng.3465","article-title":"A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.","volume":"48","author":"H Jabara","year":"2016","journal-title":"Nat Genet."},{"key":"ref-112","doi-asserted-by":"publisher","first-page":"616S-633S","DOI":"10.1093\/jn\/131.2.616S","article-title":"Iron and its relation to immunity and infectious disease.","volume":"131","author":"S Oppenheimer","year":"2001","journal-title":"J Nutr."},{"key":"ref-113","doi-asserted-by":"publisher","first-page":"158-63","DOI":"10.4103\/0976-9668.127317","article-title":"Impact of iron deficiency anemia on cell-mediated and humoral immunity in children: A case control study.","volume":"5","author":"I Das","year":"2014","journal-title":"J Nat Sci Biol Med."},{"key":"ref-114","doi-asserted-by":"publisher","first-page":"e5395","DOI":"10.1097\/MD.0000000000005395","article-title":"Impact of iron deficiency anemia on the function of the immune system in children.","volume":"95","author":"T Hassan","year":"2016","journal-title":"Medicine (Baltimore)."},{"key":"ref-115","doi-asserted-by":"publisher","first-page":"40","DOI":"10.12688\/wellcomeopenres.15750.2","article-title":"Interferon-gamma polymorphisms and risk of iron deficiency and anaemia in Gambian children [version 2; peer review: 2 approved].","volume":"5","author":"K Abuga","year":"2020","journal-title":"Wellcome Open Res."},{"key":"ref-116","doi-asserted-by":"publisher","first-page":"1660-7","DOI":"10.3324\/haematol.2010.022426","article-title":"Severe iron deficiency blunts the response of the iron regulatory gene Hamp and pro-inflammatory cytokines to lipopolysaccharide.","volume":"95","author":"D Darshan","year":"2010","journal-title":"Haematologica."},{"key":"ref-117","doi-asserted-by":"publisher","first-page":"466-73","DOI":"10.1046\/j.1365-2249.2001.01707.x","article-title":"The effects of iron deficiency on lymphocyte cytokine production and activation: preservation of hepatic iron but not at all cost.","volume":"126","author":"J Jason","year":"2001","journal-title":"Clin Exp Immunol."},{"key":"ref-118","doi-asserted-by":"publisher","first-page":"1482-500","DOI":"10.15252\/embr.201540558","article-title":"The Iron age of host-microbe interactions.","volume":"16","author":"M Soares","year":"2015","journal-title":"EMBO Rep."},{"key":"ref-119","doi-asserted-by":"publisher","first-page":"100864","DOI":"10.1016\/j.mam.2020.100864","article-title":"Iron in infection and immunity.","volume":"75","author":"M Nairz","year":"2020","journal-title":"Mol Aspects Med."},{"key":"ref-120","doi-asserted-by":"publisher","first-page":"6493","DOI":"10.3390\/ijms22126493","article-title":"Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis.","volume":"22","author":"E Nemeth","year":"2021","journal-title":"Int J Mol Sci."},{"key":"ref-121","doi-asserted-by":"publisher","first-page":"47-57","DOI":"10.1016\/j.chom.2014.12.001","article-title":"Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus.","volume":"17","author":"J Arezes","year":"2015","journal-title":"Cell Host Microbe."},{"key":"ref-122","doi-asserted-by":"publisher","first-page":"419-24","DOI":"10.1038\/nm.3483","article-title":"Inverse agonist of estrogen-related receptor gamma controls Salmonella typhimurium infection by modulating host iron homeostasis.","volume":"20","author":"D Kim","year":"2014","journal-title":"Nat Med."},{"key":"ref-123","doi-asserted-by":"publisher","first-page":"765-71","DOI":"10.1038\/nchembio.1891","article-title":"Human calprotectin is an iron-sequestering host-defense protein.","volume":"11","author":"T Nakashige","year":"2015","journal-title":"Nat Chem Biol."},{"key":"ref-124","doi-asserted-by":"publisher","first-page":"1365-81","DOI":"10.1111\/j.1462-5822.2009.01337.x","article-title":"Slc11a1 limits intracellular growth of Salmonella enterica sv. Typhimurium by promoting macrophage immune effector functions and impairing bacterial iron acquisition.","volume":"11","author":"M Nairz","year":"2009","journal-title":"Cell Microbiol."},{"key":"ref-125","doi-asserted-by":"publisher","first-page":"18984-90","DOI":"10.1074\/jbc.R115.643973","article-title":"Nramp1 and Other Transporters Involved in Metal Withholding during Infection.","volume":"290","author":"M Wessling-Resnick","year":"2015","journal-title":"J Biol Chem."},{"key":"ref-126","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1001\/archinte.1985.00360100178031","article-title":"Escherichia coli bacteremia, meningitis, and hemochromatosis.","volume":"145","author":"G Christopher","year":"1985","journal-title":"Arch Intern Med."},{"key":"ref-127","doi-asserted-by":"publisher","first-page":"1606-9","DOI":"10.1001\/archinte.1991.00400080096018","article-title":"Hemochromatosis, iron and septicemia caused by Vibrio vulnificus.","volume":"151","author":"J Bullen","year":"1991","journal-title":"Arch Intern Med."},{"key":"ref-128","doi-asserted-by":"publisher","first-page":"7-15","DOI":"10.1007\/s12185-017-2366-2","article-title":"Iron and infection.","volume":"107","author":"T Ganz","year":"2018","journal-title":"Int J Hematol."},{"key":"ref-129","doi-asserted-by":"publisher","first-page":"1923-36","DOI":"10.1002\/eji.200738056","article-title":"Interferon-gamma limits the availability of iron for intramacrophage Salmonella typhimurium.","volume":"38","author":"M Nairz","year":"2008","journal-title":"Eur J Immunol."},{"key":"ref-130","first-page":"605-10","article-title":"Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1.","volume":"20","author":"G Weiss","year":"1992","journal-title":"Exp Hematol."},{"key":"ref-131","doi-asserted-by":"publisher","first-page":"287-94","DOI":"10.1189\/jlb.0802420","article-title":"Pathways for the regulation of interferon-gamma-inducible genes by iron in human monocytic cells.","volume":"74","author":"H Oexle","year":"2003","journal-title":"J Leukoc Biol."},{"key":"ref-132","doi-asserted-by":"publisher","first-page":"3065-7","DOI":"10.1128\/IAI.74.5.3065-3067.2006","article-title":"The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica.","volume":"74","author":"S Chlosta","year":"2006","journal-title":"Infect Immun."},{"key":"ref-133","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1038\/s41467-018-04446-8","article-title":"The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages.","volume":"9","author":"D Lim","year":"2018","journal-title":"Nat Commun."},{"key":"ref-134","doi-asserted-by":"publisher","first-page":"459-474","DOI":"10.1182\/bloodadvances.2020002833","article-title":"Rapid removal of phagosomal ferroportin in macrophages contributes to nutritional immunity.","volume":"5","author":"R Flannagan","year":"2021","journal-title":"Blood Adv."},{"key":"ref-135","doi-asserted-by":"publisher","first-page":"e02211","DOI":"10.1128\/mBio.02211-14","article-title":"Salmonella enterica infection stimulates macrophages to hemophagocytose.","volume":"5","author":"M Pilonieta","year":"2014","journal-title":"mBio."},{"key":"ref-136","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3389\/fcimb.2013.00059","article-title":"Transcriptional regulation by Ferric Uptake Regulator (Fur) in pathogenic bacteria.","volume":"3","author":"B Troxell","year":"2013","journal-title":"Front Cell Infect Microbiol."},{"key":"ref-137","doi-asserted-by":"publisher","first-page":"249-262","DOI":"10.1159\/000494627","article-title":"The Iron Tug-of-War between Bacterial Siderophores and Innate Immunity.","volume":"11","author":"R Golonka","year":"2019","journal-title":"J Innate Immun."},{"key":"ref-138","doi-asserted-by":"publisher","first-page":"109-19","DOI":"10.1016\/j.chom.2007.03.001","article-title":"A Staphylococcus aureus regulatory system that responds to host heme and modulates virulence.","volume":"1","author":"V Torres","year":"2007","journal-title":"Cell Host Microbe."},{"key":"ref-139","doi-asserted-by":"publisher","first-page":"909-17","DOI":"10.1128\/JB.185.3.909-917.2003","article-title":"Heme-responsive transcriptional activation of Bordetella bhu genes.","volume":"185","author":"C Vanderpool","year":"2003","journal-title":"J Bacteriol."},{"key":"ref-140","doi-asserted-by":"publisher","first-page":"2421-31","DOI":"10.1128\/IAI.01821-06","article-title":"The ChrA-ChrS and HrrA-HrrS signal transduction systems are required for activation of the hmuO promoter and repression of the hemA promoter in Corynebacterium diphtheriae.","volume":"75","author":"L Bibb","year":"2007","journal-title":"Infect Immun."},{"key":"ref-141","doi-asserted-by":"publisher","first-page":"34-41","DOI":"10.1016\/j.cbpa.2013.12.014","article-title":"Heme uptake in bacterial pathogens.","volume":"19","author":"H Contreras","year":"2014","journal-title":"Curr Opin Chem Biol."},{"key":"ref-142","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3389\/fcimb.2019.00081","article-title":"Heme Uptake and Utilization by Gram-Negative Bacterial Pathogens.","volume":"9","author":"K Richard","year":"2019","journal-title":"Front Cell Infect Microbiol."},{"key":"ref-143","doi-asserted-by":"publisher","first-page":"917-21","DOI":"10.1038\/nature03104","article-title":"Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.","volume":"432","author":"T Flo","year":"2004","journal-title":"Nature."},{"key":"ref-144","doi-asserted-by":"publisher","first-page":"eaai8371","DOI":"10.1126\/sciimmunol.aai8371","article-title":"IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections.","volume":"2","author":"K Sakamoto","year":"2017","journal-title":"Sci Immunol."},{"key":"ref-145","doi-asserted-by":"publisher","first-page":"422-4","DOI":"10.1016\/j.chom.2009.05.005","article-title":"A precious metal heist.","volume":"5","author":"E Skaar","year":"2009","journal-title":"Cell Host Microbe."},{"key":"ref-146","doi-asserted-by":"publisher","first-page":"83-92","DOI":"10.1016\/j.jsb.2013.02.009","article-title":"Structural insight into the lactoferrin receptors from pathogenic Neisseria.","volume":"184","author":"N Noinaj","year":"2013","journal-title":"J Struct Biol."},{"key":"ref-147","doi-asserted-by":"publisher","first-page":"e02624-18","DOI":"10.1128\/mBio.02624-18","article-title":"Dopamine Is a Siderophore-Like Iron Chelator That Promotes Salmonella enterica Serovar Typhimurium Virulence in Mice.","volume":"10","author":"S Dichtl","year":"2019","journal-title":"mBio."},{"key":"ref-148","doi-asserted-by":"publisher","first-page":"100895","DOI":"10.1016\/j.mam.2020.100895","article-title":"Iron at the host-microbe interface.","volume":"75","author":"R Gerner","year":"2020","journal-title":"Mol Aspects Med."},{"key":"ref-149","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.3389\/fimmu.2018.02086","article-title":"The Diversity of Mammalian Hemoproteins and Microbial Heme Scavengers Is Shaped by an Arms Race for Iron Piracy.","volume":"9","author":"A Mozzi","year":"2018","journal-title":"Front Immunol."},{"key":"ref-150","doi-asserted-by":"publisher","first-page":"1368-78","DOI":"10.1001\/jama.2013.3010","article-title":"Effect of an investigational vaccine for preventing Staphylococcus aureus infections after cardiothoracic surgery: a randomized trial.","volume":"309","author":"V Fowler","year":"2013","journal-title":"JAMA."},{"key":"ref-151","doi-asserted-by":"publisher","first-page":"1729-36","DOI":"10.1016\/j.vaccine.2011.12.045","article-title":"The immunogenicity and safety of different formulations of a novel Staphylococcus aureus vaccine (V710): results of two Phase I studies.","volume":"30","author":"C Harro","year":"2012","journal-title":"Vaccine."},{"key":"ref-152","doi-asserted-by":"publisher","first-page":"3513-6","DOI":"10.4161\/hv.34407","article-title":"Mortality among recipients of the Merck V710 Staphylococcus aureus vaccine after postoperative S. aureus infections: an analysis of possible contributing host factors.","volume":"10","author":"T McNeely","year":"2014","journal-title":"Hum Vaccin Immunother."},{"key":"ref-153","doi-asserted-by":"publisher","first-page":"1849-1858","DOI":"10.1099\/mic.0.26131-0","article-title":"Antigenic diversity of meningococcal enterobactin receptor FetA, a vaccine component.","volume":"149","author":"E Thompson","year":"2003","journal-title":"Microbiology (Reading)."},{"key":"ref-154","doi-asserted-by":"publisher","first-page":"7164-9","DOI":"10.1128\/IAI.71.12.7164-7169.2003","article-title":"The Siderophore receptor IroN of extraintestinal pathogenic Escherichia coli is a potential vaccine candidate.","volume":"71","author":"T Russo","year":"2003","journal-title":"Infect Immun."},{"key":"ref-155","doi-asserted-by":"publisher","first-page":"518-27","DOI":"10.4049\/jimmunol.91.4.518","article-title":"The Influence of Hemolysis on Susceptibility to Salmonella Infection: Additional Observations.","volume":"91","author":"D Kaye","year":"1963","journal-title":"J Immunol."},{"key":"ref-156","doi-asserted-by":"publisher","first-page":"810-3","DOI":"10.3181\/00379727-120-30661","article-title":"Influence of Plasmodium berghei infection on susceptibility to salmonella infection.","volume":"120","author":"D Kaye","year":"1965","journal-title":"Proc Soc Exp Biol Med."},{"key":"ref-157","doi-asserted-by":"publisher","first-page":"205-15","DOI":"10.1097\/00000441-196708000-00011","article-title":"Factors influencing host resistance to Salmonella infections: the effects of hemolysis and erythrophagocytosis.","volume":"254","author":"D Kaye","year":"1967","journal-title":"Am J Med Sci."},{"key":"ref-158","doi-asserted-by":"publisher","first-page":"e00301-18","DOI":"10.1128\/IAI.00301-18","article-title":"Malaria Parasite-Mediated Alteration of Macrophage Function and Increased Iron Availability Predispose to Disseminated Nontyphoidal Salmonella Infection.","volume":"86","author":"K Lokken","year":"2018","journal-title":"Infect Immun."},{"key":"ref-159","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12916-020-1502-7","article-title":"Estimating the burden of iron deficiency among African children.","volume":"18","author":"J Muriuki","year":"2020","journal-title":"BMC Med."},{"key":"ref-160","doi-asserted-by":"publisher","first-page":"402S-415S","DOI":"10.3945\/ajcn.116.142323","article-title":"Predictors of anemia in preschool children: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.","volume":"106","author":"R Engle-Stone","year":"2017","journal-title":"Am J Clin Nutr."},{"key":"ref-161","doi-asserted-by":"publisher","first-page":"757-64","DOI":"10.4269\/ajtmh.12-0560","article-title":"Determinants of anemia among preschool children in rural, western Kenya.","volume":"88","author":"E Foote","year":"2013","journal-title":"Am J Trop Med Hyg."},{"key":"ref-162","doi-asserted-by":"publisher","first-page":"1361-1372","DOI":"10.1038\/ni.3590","article-title":"Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.","volume":"17","author":"R Martins","year":"2016","journal-title":"Nat Immunol."},{"key":"ref-163","doi-asserted-by":"publisher","first-page":"14-20","DOI":"10.1016\/j.coi.2017.10.005","article-title":"Heme and hemolysis in innate immunity: adding insult to injury.","volume":"50","author":"R Martins","year":"2018","journal-title":"Curr Opin Immunol."},{"key":"ref-164","doi-asserted-by":"publisher","first-page":"1374-89","DOI":"10.1111\/cmi.12578","article-title":"Heme oxygenase 1 controls early innate immune response of macrophages to Salmonella Typhimurium infection.","volume":"18","author":"A Mitterstiller","year":"2016","journal-title":"Cell Microbiol."},{"key":"ref-165","doi-asserted-by":"publisher","first-page":"331-8","DOI":"10.1016\/j.chom.2008.04.003","article-title":"Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection.","volume":"3","author":"S Epiphanio","year":"2008","journal-title":"Cell Host Microbe."},{"key":"ref-166","doi-asserted-by":"publisher","first-page":"253-266","DOI":"10.1038\/s41385-020-00342-x","article-title":"Heme oxygenase-1 inhibition promotes IFN\u03b3- and NOS2-mediated control of Mycobacterium tuberculosis infection.","volume":"14","author":"D Costa","year":"2021","journal-title":"Mucosal Immunol."},{"key":"ref-167","doi-asserted-by":"publisher","first-page":"50-8","DOI":"10.1016\/j.molmed.2008.12.004","article-title":"Heme oxygenase-1: from biology to therapeutic potential.","volume":"15","author":"M Soares","year":"2009","journal-title":"Trends Mol Med."},{"key":"ref-168","doi-asserted-by":"publisher","first-page":"833-43","DOI":"10.1016\/s0022-3476(75)80211-3","article-title":"The immune response in iron-deficient children: Impaired cellular defense mechanisms with altered humoral components.","volume":"86","author":"L Macdougall","year":"1975","journal-title":"J Pediatr."},{"key":"ref-169","doi-asserted-by":"publisher","first-page":"1307-1309","DOI":"10.1016\/s0140-6736(76)92647-7","article-title":"Anaemia and immune response.","volume":"307","author":"S Srikantia","year":"1976","journal-title":"Lancet."},{"key":"ref-170","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.1038\/s41598-021-82330-0","article-title":"Events associated with susceptibility to invasive Salmonella enterica serovar Typhi in BALB\/c mice previously infected with Plasmodium berghei ANKA.","volume":"11","author":"Y Moreira","year":"2021","journal-title":"Sci Rep."},{"key":"ref-171","doi-asserted-by":"publisher","first-page":"169-75","DOI":"10.1016\/0925-4439(96)00021-x","article-title":"Phagocytosis of malarial pigment hemozoin inhibits NADPH-oxidase activity in human monocyte-derived macrophages.","volume":"1316","author":"E Schwarzer","year":"1996","journal-title":"Biochim Biophys Acta."},{"key":"ref-172","doi-asserted-by":"publisher","first-page":"942-9","DOI":"10.1046\/j.1365-2141.1998.01126.x","article-title":"Dyserythropoiesis and severe anaemia associated with malaria correlate with deficient interleukin-12 production.","volume":"103","author":"K Mohan","year":"1998","journal-title":"Br J Haematol."},{"key":"ref-173","doi-asserted-by":"publisher","first-page":"1755-7","DOI":"10.1086\/425021","article-title":"Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans.","volume":"190","author":"C MacLennan","year":"2004","journal-title":"J Infect Dis."},{"key":"ref-174","doi-asserted-by":"publisher","first-page":"103568","DOI":"10.1016\/j.ebiom.2021.103568","article-title":"Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice.","volume":"71","author":"A Hoffmann","year":"2021","journal-title":"EBioMedicine."},{"key":"ref-175","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s12879-016-1604-1","article-title":"Microbiological, clinical and molecular findings of non-typhoidal Salmonella bloodstream infections associated with malaria, Oriental Province, Democratic Republic of the Congo.","volume":"16","author":"D Falay","year":"2016","journal-title":"BMC Infect Dis."},{"key":"ref-176","doi-asserted-by":"publisher","first-page":"230-6","DOI":"10.1097\/01.inf.0000202066.02212.ff","article-title":"Salmonella bacteremia in Kenyan children.","volume":"25","author":"A Brent","year":"2006","journal-title":"Pediatr Infect Dis J."},{"key":"ref-177","doi-asserted-by":"publisher","first-page":"895-904","DOI":"10.1086\/511437","article-title":"Bacteremia in Malawian children with severe malaria: prevalence, etiology, HIV coinfection, and outcome.","volume":"195","author":"R Bronzan","year":"2007","journal-title":"J Infect Dis."},{"key":"ref-178","first-page":"11-5","article-title":"The pattern of bacteraemia in children with severe malaria.","volume":"14","author":"S Graham","year":"2002","journal-title":"Malawi Med J."},{"key":"ref-179","doi-asserted-by":"publisher","first-page":"310-4","DOI":"10.1016\/s0035-9203(00)90337-7","article-title":"Clinical presentation of non-typhoidal Salmonella bacteraemia in Malawian children.","volume":"94","author":"S Graham","year":"2000","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"ref-180","doi-asserted-by":"publisher","first-page":"312-8","DOI":"10.1097\/00006454-200004000-00010","article-title":"Bacteremia in febrile Malawian children: clinical and microbiologic features.","volume":"19","author":"A Walsh","year":"2000","journal-title":"Pediatr Infect Dis J."},{"key":"ref-181","doi-asserted-by":"publisher","first-page":"S339-45","DOI":"10.1093\/cid\/civ712","article-title":"Invasive Salmonella Infections Among Children From Rural Mozambique, 2001-2014.","volume":"61 Suppl 4","author":"I Mandomando","year":"2015","journal-title":"Clin Infect Dis."},{"key":"ref-182","doi-asserted-by":"publisher","first-page":"1467-74","DOI":"10.1111\/j.1365-3156.2009.02399.x","article-title":"Invasive non-typhoidal Salmonella in Mozambican children.","volume":"14","author":"I Mandomando","year":"2009","journal-title":"Trop Med Int Health."},{"key":"ref-183","doi-asserted-by":"publisher","first-page":"638-47","DOI":"10.1093\/cid\/cit798","article-title":"Invasive Salmonella infections in areas of high and low malaria transmission intensity in Tanzania.","volume":"58","author":"H Biggs","year":"2014","journal-title":"Clin Infect Dis."},{"key":"ref-184","doi-asserted-by":"publisher","first-page":"e9244","DOI":"10.1371\/journal.pone.0009244","article-title":"Invasive salmonellosis among children admitted to a rural Tanzanian hospital and a comparison with previous studies.","volume":"5","author":"G Mtove","year":"2010","journal-title":"PLoS One."},{"key":"ref-185","doi-asserted-by":"publisher","first-page":"S23-31","DOI":"10.1093\/cid\/civ893","article-title":"The Relationship Between Invasive Nontyphoidal Salmonella Disease, Other Bacterial Bloodstream Infections, and Malaria in Sub-Saharan Africa.","volume":"62 Suppl 1","author":"S Park","year":"2016","journal-title":"Clin Infect Dis."},{"key":"ref-186","doi-asserted-by":"publisher","first-page":"1478-93","DOI":"10.4161\/hv.29054","article-title":"Vaccines against invasive Salmonella disease: current status and future directions.","volume":"10","author":"C MacLennan","year":"2014","journal-title":"Hum Vaccin Immunother."},{"key":"ref-187","doi-asserted-by":"publisher","first-page":"287-302","DOI":"10.1038\/s41579-020-00506-3","article-title":"The role of vaccines in combatting antimicrobial resistance.","volume":"19","author":"F Micoli","year":"2021","journal-title":"Nat Rev Microbiol."},{"key":"ref-188","doi-asserted-by":"publisher","first-page":"e666-e669","DOI":"10.1016\/S2352-3026(21)00201-5","article-title":"Vaccine efficacy and iron deficiency: an intertwined pair?","volume":"8","author":"H Drakesmith","year":"2021","journal-title":"Lancet Haematol."},{"key":"ref-189","doi-asserted-by":"publisher","first-page":"2154s-218s","DOI":"10.3945\/jn.109.105312","article-title":"Landscape analysis of interactions between nutrition and vaccine responses in children.","volume":"139","author":"M Savy","year":"2009","journal-title":"J Nutr."},{"key":"ref-190","first-page":"405-7","article-title":"The immune response in iron-deficient children. Isohaemagglutinin titres and antibody response to immunization.","volume":"53","author":"L MacDougall","year":"1978","journal-title":"S Afr Med J."},{"key":"ref-191","doi-asserted-by":"publisher","first-page":"1249-51","DOI":"10.1136\/bmj.280.6226.1249","article-title":"Humoral immune response in children with iron-deficiency anaemia.","volume":"280","author":"K Bagchi","year":"1980","journal-title":"Br Med J."},{"key":"ref-192","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.3389\/fimmu.2020.01313","article-title":"Iron Deficiency Anemia at Time of Vaccination Predicts Decreased Vaccine Response and Iron Supplementation at Time of Vaccination Increases Humoral Vaccine Response: A Birth Cohort Study and a Randomized Trial Follow-Up Study in Kenyan Infants.","volume":"11","author":"N Stoffel","year":"2020","journal-title":"Front Immunol."},{"key":"ref-193","doi-asserted-by":"publisher","first-page":"62-8","DOI":"10.1128\/cdli.2.1.62-68.1995","article-title":"Effect of malnutrition in Ecuadorian children on titers of serum antibodies to various microbial antigens.","volume":"2","author":"H Br\u00fcssow","year":"1995","journal-title":"Clin Diagn Lab Immunol."}],"container-title":["Wellcome Open Research"],"language":"en","link":[{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-48\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-48\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-48\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T06:07:29Z","timestamp":1692338849000},"score":9.741658,"resource":{"primary":{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-48\/v1"}},"issued":{"date-parts":[[2023,2,2]]},"references-count":193,"URL":"https:\/\/doi.org\/10.12688\/wellcomeopenres.18829.1","relation":{"has-review":[{"id-type":"doi","id":"10.21956\/wellcomeopenres.20875.r61498","asserted-by":"subject"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.20875.r55343","asserted-by":"subject"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.20875.r61498","asserted-by":"object"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.20875.r55343","asserted-by":"object"}]},"ISSN":["2398-502X"],"issn-type":[{"value":"2398-502X","type":"electronic"}],"published":{"date-parts":[[2023,2,2]]},"assertion":[{"value":"Indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-48\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/wellcomeopenres.20875.r55343, Jason P. Mooney, Institute of Immunology and Infection Research, The University of Edinburgh, Edinburgh, Scotland, 24 Mar 2023, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-48\/v1#referee-response-55343","order":0,"name":"referee-response-55343","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.20875.r61498, Gaetano Cairo, Department of Biomedical Sciences for Health, Universita degli Studi di Milano, Milan, Lombardy, 18 Aug 2023, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-48\/v1#referee-response-61498","order":1,"name":"referee-response-61498","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by Wellcome [226014 to SHA; 224315 to KMA; 203077, https:\/\/doi.org\/10.35802\/203077<\/a>, a core award to the KEMRI-Wellcome Trust Research Programme]; the DELTAS Africa Initiative [DEL-15-003 to KMA]. The DELTAS Africa Initiative is an independent funding scheme of the African Academy of Sciences (AAS)'s Alliance for Accelerating Excellence in Science in Africa (AESA) and supported by the New Partnership for Africa's Development Planning and Coordinating Agency (NEPAD Agency) with funding from Wellcome [107769] and the UK government. For the purpose of Open Access, the author has applied a CC-BY public copyright licence to any author accepted manuscript version arising from this submission. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]},{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T03:29:33Z","timestamp":1767151773106,"version":"build-2238731810"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"],"award-info":[{"award-number":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"],"award-info":[{"award-number":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"],"award-info":[{"award-number":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"],"award-info":[{"award-number":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"],"award-info":[{"award-number":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"],"award-info":[{"award-number":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"],"award-info":[{"award-number":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"],"award-info":[{"award-number":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"],"award-info":[{"award-number":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"],"award-info":[{"award-number":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"],"award-info":[{"award-number":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"],"award-info":[{"award-number":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"],"award-info":[{"award-number":["202922\/Z\/16\/Z, 104085\/Z\/14\/Z, 088158\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"Abstract<\/jats:title>\n Absolute risks of stroke are typically estimated using measurements of cardiovascular disease risk factors recorded at a single visit. However, the comparative utility of single versus sequential risk factor measurements for stroke prediction is unclear. Risk factors were recorded on three separate visits on 13,753 individuals in the prospective China Kadoorie Biobank. All participants were stroke-free at baseline (2004\u20132008), first resurvey (2008), and second resurvey (2013\u20132014), and were followed-up for incident cases of first stroke in the 3\u00a0years following the second resurvey. To reflect the models currently used in clinical practice, sex-specific Cox models were developed to estimate 3-year risks of stroke using single measurements recorded at second resurvey and were retrospectively applied to risk factor data from previous visits. Temporal trends in the Cox-generated risk estimates from 2004 to 2014 were analyzed using linear mixed effects models. To assess the value of more flexible machine learning approaches and the incorporation of longitudinal data, we developed gradient boosted tree (GBT) models for 3-year prediction of stroke using both single measurements and sequential measurements of risk factor inputs. Overall, Cox-generated estimates for 3-year stroke risk increased by 0.3% per annum in men and 0.2% per annum in women, but varied substantially between individuals. The risk estimates at second resurvey were highly correlated with the annual increase of risk for each individual (men: r\u2009=\u20090.91, women: r\u2009=\u20090.89), and performance of the longitudinal GBT models was comparable with both Cox and GBT models that considered measurements from only a single visit (AUCs: 0.779\u20130.811 in men, 0.724\u20130.756 in women). These results provide support for current clinical guidelines, which recommend using risk factor measurements recorded at a single visit for stroke prediction.<\/jats:p>","DOI":"10.1038\/s41598-021-95244-8","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:16:11Z","timestamp":1632960971000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utility of single versus sequential measurements of risk factors for prediction of stroke in Chinese adults"],"prefix":"10.1038","volume":"11","author":[{"given":"Matthew","family":"Chun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Clifton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derrick","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canqing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J.","family":"Cairns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the China Kadoorie Biobank Collaborative Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"International Steering Committee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junshi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rory","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Peto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Walters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"International Co-ordinating Centre, Oxford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Avery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derrick","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Boxall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Bragg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushila","family":"Burgess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kahung","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaidong","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zammy","family":"Fairhurst-Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Hacker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parisa","family":"Hariri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andri","family":"Iona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Becky","family":"Im","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kakkoura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiana","family":"Kartsonaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene","family":"Kerosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iona","family":"Millwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qunhua","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"Pozaricki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Ryder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Sansome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajani","family":"Sohoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iain","family":"Turnbull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Walters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"National Co-ordinating Centre, Beijing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canqing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Regional Co-ordinating Centres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengchang","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruqin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanpeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaojie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranran","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaocao","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoming","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silu","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junzheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyuan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shichun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhendong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shukuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonglin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihe","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangcai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianrong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingchao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhuai","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qilian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuping","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanwen","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunfu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guojin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunfu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caixia","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enke","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shixian","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyou","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huarong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xukui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaixu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongxia","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qijun","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuelong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huilin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongxi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaohua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huajun","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"95244_CR1","unstructured":"Institute for Health Metrics and Evaluation (IHME). GBD Compare. Seattle, WA: IHME, University of Washington, 2015. http:\/\/vizhub.healthdata.org\/gbd-compare. Accessed January 18, 2021"},{"key":"95244_CR2","doi-asserted-by":"publisher","first-page":"S74","DOI":"10.1161\/01.cir.0000437741.48606.98","volume":"129","author":"DC Goff Jr","year":"2014","unstructured":"Goff, D. C. Jr. et al. 2013 ACC\/AHA guideline on the assessment of cardiovascular risk: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. Circulation 129, S74\u2013S75 (2014).","journal-title":"Circulation"},{"key":"95244_CR3","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1161\/CIRCULATIONAHA.115.021275","volume":"135","author":"C Dufouil","year":"2017","unstructured":"Dufouil, C. et al. Revised Framingham stroke risk profile to reflect temporal trends. Circulation 135, 1145\u20131159 (2017).","journal-title":"Circulation"},{"key":"95244_CR4","doi-asserted-by":"publisher","first-page":"3754","DOI":"10.1161\/STR.0000000000000046","volume":"45","author":"JF Meschia","year":"2014","unstructured":"Meschia, J. F. et al. Guidelines for the primary prevention of stroke: A statement for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke 45, 3754\u20133832 (2014).","journal-title":"Stroke"},{"key":"95244_CR5","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1136\/svn-2020-000385","volume":"5","author":"Y Wang","year":"2020","unstructured":"Wang, Y. et al. Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: Executive summary and 2019 update of the management of high-risk population. Stroke Vasc Neurol. 5, 270\u2013278 (2020).","journal-title":"Stroke Vasc Neurol."},{"key":"95244_CR6","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1093\/eurheartj\/ehm316","volume":"28","author":"I Graham","year":"2007","unstructured":"Graham, I. et al. European Society of Cardiology (ESC) Committee for Practice Guidelines (CPG). European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by representatives of nine societies and by invited experts). Eur Heart J. 28, 2375\u20132414 (2007).","journal-title":"Eur Heart J."},{"issue":"25","key":"95244_CR7","first-page":"49","volume":"129","author":"DC Goff","year":"2014","unstructured":"Goff, D. C. et al. American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. 2013 ACC\/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. Circulation 129(25), 49\u201373 (2014).","journal-title":"Circulation"},{"key":"95244_CR8","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1001\/jama.2014.2632","volume":"311","author":"M Kavousi","year":"2014","unstructured":"Kavousi, M. et al. Comparison of application of the ACC\/AHA guidelines, Adult Treatment Panel III guidelines, and European Society of Cardiology guidelines for cardiovascular disease prevention in a European cohort. JAMA 311, 1416\u20131423 (2014).","journal-title":"JAMA"},{"key":"95244_CR9","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1080\/07853890.2020.1733648","volume":"52","author":"J Nuotio","year":"2020","unstructured":"Nuotio, J., Suvila, K., Cheng, S., Lang\u00e9n, V. & Niiranen, T. Longitudinal blood pressure patterns and cardiovascular disease risk. Ann. Med. 52, 43\u201354 (2020).","journal-title":"Ann. Med."},{"key":"95244_CR10","doi-asserted-by":"publisher","first-page":"4514","DOI":"10.1002\/sim.7144","volume":"36","author":"MJ Sweeting","year":"2017","unstructured":"Sweeting, M. J., Barrett, J. K., Thompson, S. G. & Wood, A. M. The use of repeated blood pressure measures for cardiovascular risk prediction: A comparison of statistical models in the ARIC study. Stat. Med. 36, 4514\u20134528 (2017).","journal-title":"Stat. Med."},{"key":"95244_CR11","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.annepidem.2011.12.001","volume":"22","author":"NP Paynter","year":"2012","unstructured":"Paynter, N. P., Crainiceanu, C. M., Sharrett, A. R., Chambless, L. E. & Coresh, J. Effect of correcting for long-term variation in major coronary heart disease risk factors: Relative hazard estimation and risk prediction in the Atherosclerosis Risk in Communities Study. Ann. Epidemiol. 22, 191\u2013197 (2012).","journal-title":"Ann. Epidemiol."},{"key":"95244_CR12","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1093\/aje\/kwx149","volume":"186","author":"E Paige","year":"2017","unstructured":"Paige, E. et al. Use of repeated blood pressure and cholesterol measurements to improve cardiovascular disease risk prediction: An individual-participant-data meta-analysis. Am. J. Epidemiol. 186, 899\u2013907 (2017).","journal-title":"Am. J. Epidemiol."},{"key":"95244_CR13","doi-asserted-by":"publisher","first-page":"4197","DOI":"10.1161\/CIRCOUTCOMES.117.004197","volume":"10","author":"IJ Cho","year":"2017","unstructured":"Cho, I. J., Sung, J. M., Chang, H. J., Chung, N. & Kim, H. C. Incremental value of repeated risk factor measurements for cardiovascular disease prediction in middle-aged Korean adults. Circ. Cardiovasc. Qual. Outcomes 10, 4197 (2017).","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"95244_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-37186-2","volume":"9","author":"J Zhao","year":"2019","unstructured":"Zhao, J. et al. Learning from longitudinal data in electronic health record and genetic data to improve cardiovascular event prediction. Sci. Rep. 9, 1\u201310 (2019).","journal-title":"Sci. Rep."},{"key":"95244_CR15","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1093\/ije\/dyi174","volume":"34","author":"Z Chen","year":"2005","unstructured":"Chen, Z. et al. Cohort profile: The Kadoorie Study of Chronic Disease in China (KSCDC). Int. J. Epidemiol. 34, 1243\u20131249 (2005).","journal-title":"Int. J. Epidemiol."},{"key":"95244_CR16","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1093\/ije\/dyr120","volume":"40","author":"Z Chen","year":"2011","unstructured":"Chen, Z. et al. China Kadoorie Biobank of 0\u00b75 million people: survey methods, baseline characteristics and long-term follow-up. Int. J. Epidemiol. 40, 1652\u20131666 (2011).","journal-title":"Int. J. Epidemiol."},{"key":"95244_CR17","first-page":"ocab068","volume":"1","author":"M Chun","year":"2021","unstructured":"Chun, M. et al. Stroke risk prediction using machine learning: a prospective cohort study of 05 million Chinese adults. JAMIA. 1, ocab068 (2021).","journal-title":"JAMIA."},{"key":"95244_CR18","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2307\/2531595","volume":"44","author":"ER DeLong","year":"1988","unstructured":"DeLong, E. R., DeLong, D. M. & Clarke-Pearson, D. L. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44, 837\u2013845 (1988).","journal-title":"Biometrics"},{"key":"95244_CR19","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/S0140-6736(81)90791-1","volume":"318","author":"R Peto","year":"1981","unstructured":"Peto, R. The horse-racing effect. Lancet 318, 467\u2013468 (1981).","journal-title":"Lancet"},{"issue":"4","key":"95244_CR20","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","volume":"15","author":"FE Harrell","year":"1996","unstructured":"Harrell, F. E., Lee, K. L. & Mark, D. B. Multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat. Med. 15(4), 361\u2013387 (1996).","journal-title":"Stat. Med."},{"key":"95244_CR21","first-page":"11","volume":"156","author":"PM Burch","year":"2017","unstructured":"Burch, P. M. et al. Net reclassification index and integrated discrimination index are not appropriate for testing whether a biomarker improves predictive performance. Toxic. Sci. 156, 11\u201313 (2017).","journal-title":"Toxic. Sci."},{"key":"95244_CR22","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.amjcard.2018.05.015","volume":"122","author":"Z Wang","year":"2018","unstructured":"Wang, Z. et al. The disease burden of atrial fibrillation in China from a National Cross-sectional Survey. J. Am. Coll. Cardiol. 122, 793\u2013798 (2018).","journal-title":"J. Am. Coll. Cardiol."},{"key":"95244_CR23","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1161\/CIRCULATIONAHA.111.065904","volume":"125","author":"W Yang","year":"2012","unstructured":"Yang, W. et al. Serum Lipids and Lipoproteins in Chinese Men and Women. Circutlation. 125, 2212\u20132221 (2012).","journal-title":"Circutlation."}],"updated-by":[{"DOI":"10.1038\/s41598-021-00401-8","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000}}],"container-title":["Scientific Reports"],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-95244-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-95244-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-95244-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T10:34:11Z","timestamp":1670063651000},"score":9.741174,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-95244-8"}},"issued":{"date-parts":[[2021,9,2]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["95244"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-95244-8","ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"published":{"date-parts":[[2021,9,2]]},"assertion":[{"value":"10 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-021-00401-8","URL":"https:\/\/doi.org\/10.1038\/s41598-021-00401-8","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17575"},{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:30:56Z","timestamp":1778725856332,"version":"3.51.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["074048\/Z\/05\/Z"],"award-info":[{"award-number":["074048\/Z\/05\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["074048\/Z\/05\/Z"],"award-info":[{"award-number":["074048\/Z\/05\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["074048\/Z\/05\/Z"],"award-info":[{"award-number":["074048\/Z\/05\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["074048\/Z\/05\/Z"],"award-info":[{"award-number":["074048\/Z\/05\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["074048\/Z\/05\/Z"],"award-info":[{"award-number":["074048\/Z\/05\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["074048\/Z\/05\/Z"],"award-info":[{"award-number":["074048\/Z\/05\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["074048\/Z\/05\/Z"],"award-info":[{"award-number":["074048\/Z\/05\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["074048\/Z\/05\/Z"],"award-info":[{"award-number":["074048\/Z\/05\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["074048\/Z\/05\/Z"],"award-info":[{"award-number":["074048\/Z\/05\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["074048\/Z\/05\/Z"],"award-info":[{"award-number":["074048\/Z\/05\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["074048\/Z\/05\/Z"],"award-info":[{"award-number":["074048\/Z\/05\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["074048\/Z\/05\/Z"],"award-info":[{"award-number":["074048\/Z\/05\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["074048\/Z\/05\/Z"],"award-info":[{"award-number":["074048\/Z\/05\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["074048\/Z\/05\/Z"],"award-info":[{"award-number":["074048\/Z\/05\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1038\/s41430-019-0429-6","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T10:02:51Z","timestamp":1559296971000},"page":"1536-1545","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Dietary micronutrient intakes among women of reproductive age in Mumbai slums"],"prefix":"10.1038","volume":"73","author":[{"given":"Rebecca L.","family":"Nunn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah H.","family":"Kehoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harsha","family":"Chopra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirazul A.","family":"Sahariah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meera","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Di Gravio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patsy J.","family":"Coakley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa A.","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshad","family":"Sane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devi","family":"Shivshankaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ella","family":"Marley-Zagar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barrie M.","family":"Margetts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan A.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh D.","family":"Potdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline H. D.","family":"Fall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,31]]},"reference":[{"key":"429_CR1","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.3390\/nu7031744","volume":"7","author":"I Darnton-Hill","year":"2015","unstructured":"Darnton-Hill I, Mkparu UC. Micronutrients in pregnancy in low- and middle-income countries. Nutrients. 2015;7:1744\u201368.","journal-title":"Nutrients"},{"key":"429_CR2","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1093\/jn\/135.5.1106","volume":"135","author":"TN Jiang","year":"2005","unstructured":"Jiang TN, Christian P, Khatry SK, Wu L, West KP. Micronutrient deficiencies in early pregnancy are common, concurrent, and vary by season among rural nepali pregnant women. J Nutr. 2005;135:1106\u201312.","journal-title":"J Nutr"},{"key":"429_CR3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1159\/000365792","volume":"65","author":"RA Salam","year":"2014","unstructured":"Salam RA, Das JK, Bhutta ZA. Multiple micronutrient supplementation during pregnancy and lactation in low-to-middle-income developing country settings: impact on pregnancy outcomes. Ann Nutr Metab. 2014;65:4\u201312.","journal-title":"Ann Nutr Metab"},{"key":"429_CR4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/bmb\/ldt015","volume":"106","author":"ZA Bhutta","year":"2013","unstructured":"Bhutta ZA, Salam RA, Das JK. Meeting the challenges of micronutrient malnutrition in the developing world. Br Med Bull. 2013;106:7\u201317.","journal-title":"Br Med Bull"},{"key":"429_CR5","volume-title":"Essential nutrition actions: improving maternal, newborn, infant and young child health and nutrition","author":"World Health Organization.","year":"2013","unstructured":"World Health Organization. Essential nutrition actions: improving maternal, newborn, infant and young child health and nutrition. Geneva: World Health Organization; 2013."},{"key":"429_CR6","first-page":"79","volume":"81","author":"R Black","year":"2003","unstructured":"Black R. Micronutrient deficiency\u2014an underlying cause of morbidity and mortality. Bull World Health Organ. 2003;81:79\u201379.","journal-title":"Bull World Health Organ"},{"key":"429_CR7","doi-asserted-by":"publisher","first-page":"S40","DOI":"10.1301\/00296640260130722","volume":"60","author":"P Bhaskaram","year":"2002","unstructured":"Bhaskaram P. Micronutrient malnutrition, infection, and immunity: an overview. Nutr Rev. 2002;60:S40\u2013S45.","journal-title":"Nutr Rev"},{"key":"429_CR8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s12011-007-8067-6","volume":"122","author":"A Kassu","year":"2008","unstructured":"Kassu A, Yabutani T, Mulu A, Tessema B, Ota F. Serum zinc, copper, selenium, calcium, and magnesium levels in pregnant and non-pregnant women in Gondar, northwest Ethiopia. Biol Trace Elem Res. 2008;122:97\u2013106.","journal-title":"Biol Trace Elem Res"},{"key":"429_CR9","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/S0140-6736(13)60996-4","volume":"382","author":"ZA Bhutta","year":"2013","unstructured":"Bhutta ZA, Das JK, Rizvi A, Gaffey MF, Walker N, Horton S, et al. Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost? Lancet. 2013;382:452\u201377.","journal-title":"Lancet"},{"key":"429_CR10","first-page":"983","volume":"36","author":"U Kapil","year":"1999","unstructured":"Kapil U, Pathak P, Tandon M, Singh C, Pradhan R, Dwivedi SN. Micronutrient deficiency disorders amongst pregnant women in three urban slum communities of Delhi. Indian Pediatr. 1999;36:983\u20139.","journal-title":"Indian Pediatr"},{"key":"429_CR11","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1007\/BF02828117","volume":"71","author":"P Pathak","year":"2004","unstructured":"Pathak P, Kapil U, Kapoor SK, Saxena R, Kumar A, Gupta N, et al. Prevalence of multiple micronutrient deficiencies amongst pregnant women in a rural area of Haryana. Indian J Pediatr. 2004;71:1007\u201314.","journal-title":"Indian J Pediatr"},{"key":"429_CR12","volume-title":"National Family Health Survey (NFHS-3), India, 2005\u201306: Maharashtra","author":"International Institute for Population Sciences (IIPS) and Macro International.","year":"2008","unstructured":"International Institute for Population Sciences (IIPS) and Macro International. National Family Health Survey (NFHS-3), India, 2005\u201306: Maharashtra. Mumbai: International Institute for Population Sciences; 2008."},{"key":"429_CR13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.bpobgyn.2011.10.010","volume":"26","author":"M Goonewardene","year":"2012","unstructured":"Goonewardene M, Shehata M, Hamad A. Anaemia in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2012;26:3\u201324.","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"429_CR14","volume-title":"Mothers, babies and health in later life","author":"D Barker","year":"1998","unstructured":"Barker D. Mothers, babies and health in later life. Edinburgh, UK: Churchill Livingstone; 1998."},{"key":"429_CR15","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1093\/tropej\/43.4.192-a","volume":"43","author":"A Ploysangam","year":"1997","unstructured":"Ploysangam A, Falciglia GA, Brehm BJ. Effect of marginal zinc deficiency on human growth and development. J Trop Pediatr. 1997;43:192\u20138.","journal-title":"J Trop Pediatr"},{"key":"429_CR16","first-page":"9","volume":"9","author":"PH Nguyen","year":"2014","unstructured":"Nguyen PH, Nguyen H, Gonzalez-Casanova I, Copeland E, Strizich G, Lowe A, et al. Micronutrient intakes among women of reproductive age in Vietnam. Plos One. 2014;9:9.","journal-title":"Plos One"},{"key":"429_CR17","doi-asserted-by":"publisher","first-page":"1206S","DOI":"10.1093\/ajcn\/81.5.1206","volume":"81","author":"LH Allen","year":"2005","unstructured":"Allen LH. Multiple micronutrients in pregnancy and lactation: an overview. Am J Clin Nutr. 2005;81:1206S\u20131212S.","journal-title":"Am J Clin Nutr"},{"key":"429_CR18","doi-asserted-by":"publisher","first-page":"1198S","DOI":"10.1093\/ajcn\/81.5.1198","volume":"81","author":"I Darnton-Hill","year":"2005","unstructured":"Darnton-Hill I, Webb P, Harvey PWJ, Hunt JM, Dalmiya N, Chopra M, et al. Micronutrient deficiencies and gender: social and economic costs. Am J Clin Nutr. 2005;81:1198S\u20131205S.","journal-title":"Am J Clin Nutr"},{"key":"429_CR19","unstructured":"Briones Alonso E. The impact of culture, religion and traditional knowledge on food and nutrition security in developing countries. Food Secure, 2015."},{"key":"429_CR20","first-page":"485","volume":"129","author":"S Isharwal","year":"2009","unstructured":"Isharwal S, Misra A, Wasir JS, Nigam P. Diet & insulin resistance: a review & Asian Indian perspective. Indian J Med Res. 2009;129:485\u201399.","journal-title":"Indian J Med Res"},{"key":"429_CR21","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1017\/S0007114508073649","volume":"101","author":"A Misra","year":"2009","unstructured":"Misra A, Khurana L, Isharwal S, Bhardwaj S. South Asian diets and insulin resistance. Br J Nutr. 2009;101:465\u201373.","journal-title":"Br J Nutr"},{"key":"429_CR22","volume-title":"Report of Urban survey\u2014slums (1993\u201394)","author":"National Institute of Nutrition.","year":"1994","unstructured":"National Institute of Nutrition. Report of Urban survey\u2014slums (1993\u201394). Hyderabad: Indian Council of Medical Research; 1994."},{"key":"429_CR23","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1017\/S0007114507803965","volume":"99","author":"G Radhika","year":"2008","unstructured":"Radhika G, Sudha V, Sathya RM, Ganesan A, Mohan V. Association of fruit and vegetable intake with cardiovascular risk factors in urban south Indians. Br J Nutr. 2008;99:398\u2013405.","journal-title":"Br J Nutr"},{"key":"429_CR24","first-page":"99","volume":"38","author":"KV Murty","year":"1994","unstructured":"Murty KV, Reddy KJ. Dietary patterns and selected anthropometric indices in reproductive age women of a slum in urban: Kurnool. Indian J public health. 1994;38:99\u2013102.","journal-title":"Indian J public health"},{"key":"429_CR25","first-page":"1","volume":"14","author":"H Chopra","year":"2012","unstructured":"Chopra H, Chheda P, Kehoe S, Taskar V, Brown N, Shivashankaran D, et al. Dietary habits of female urban slum-dwellers in Mumbai. Indian J Matern Child Health. 2012;14:1\u201313.","journal-title":"Indian J Matern Child Health"},{"key":"429_CR26","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1093\/jn\/131.4.1217","volume":"131","author":"S Rao","year":"2001","unstructured":"Rao S, Yajnik CS, Kanade A, Fall CHD, Margetts BM, Jackson AA, et al. Intake of micronutrient-rich foods in rural Indian mothers is associated with the size of their babies at birth: Pune maternal nutrition study. J Nutr. 2001;131:1217\u201324.","journal-title":"J Nutr"},{"key":"429_CR27","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1079\/PHN2002367","volume":"6","author":"LT Andersen","year":"2003","unstructured":"Andersen LT, Thilsted SH, Nielsen BB, Rangasamy S. Food and nutrient intakes among pregnant women in rural Tamil Nadu, South India. Public Health Nutr. 2003;6:131\u20137.","journal-title":"Public Health Nutr"},{"key":"429_CR28","doi-asserted-by":"publisher","first-page":"2051S","DOI":"10.3945\/jn.110.123463","volume":"140","author":"LE Torheim","year":"2010","unstructured":"Torheim LE, Ferguson EL, Penrose K, Arimond M. Women in resource-poor settings are at risk of inadequate intakes of multiple micronutrients. J Nutr. 2010;140:2051S\u20132058S.","journal-title":"J Nutr"},{"key":"429_CR29","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.3945\/ajcn.114.084921","volume":"100","author":"RD Potdar","year":"2014","unstructured":"Potdar RD, Sahariah SA, Gandhi M, Kehoe SH, Brown N, Sane H, et al. Improving women\u2019s diet quality preconceptionally and during gestation: effects on birth weight and prevalence of low birth weight-a randomized controlled efficacy trial in India (Mumbai Maternal Nutrition Project). Am J Clin Nutr. 2014;100:1257\u201368.","journal-title":"Am J Clin Nutr"},{"key":"429_CR30","volume-title":"National Family Health Survey (NFHS-2), India, 1998\u201399","author":"International Institute for Population sciences (IIPS) and Operations Research Centre (ORC) Macro.","year":"2000","unstructured":"International Institute for Population sciences (IIPS) and Operations Research Centre (ORC) Macro. National Family Health Survey (NFHS-2), India, 1998\u201399. Maharashtra: International Institute for Population Sciences Mumbai; 2000."},{"key":"429_CR31","volume-title":"McCance & Widdowson\u2019s The composition of foods integrated dataset. Version 6, Sixth summary edition","author":"The Food Standards Agency.","year":"2002","unstructured":"The Food Standards Agency. McCance & Widdowson\u2019s The composition of foods integrated dataset. Version 6, Sixth summary edition. Cambridge: The Stationary Office; 2002."},{"key":"429_CR32","volume-title":"Vitamin and mineral requirements in human nutrition","author":"World Health Organization and Food and Agriculture Organization of the United Nations.","year":"2004","unstructured":"World Health Organization and Food and Agriculture Organization of the United Nations. Vitamin and mineral requirements in human nutrition. 2nd edn. Rome: Report of a Joint FAO\/WHO Expert Consultation. Food and Agriculture Organization; 2004.","edition":"2nd edn"},{"key":"429_CR33","first-page":"1","volume":"41","author":"Committee on Medical Aspects of Food Policy.","year":"1991","unstructured":"Committee on Medical Aspects of Food Policy. Dietary reference values for food energy and nutrients for the United Kingdom. Report of the Panel on Dietary Reference Values of the Committee on Medical Aspects of Food Policy. Rep health Soc Subj. 1991;41:1\u2013210.","journal-title":"Rep health Soc Subj"},{"key":"429_CR34","unstructured":"Institute of Medicine Panel on Dietary Antioxidants and Related Compounds. Vitamin E. In: Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. National Academies Press (US): Washington (DC); 2000, pp 186\u2013262."},{"key":"429_CR35","unstructured":"Institute of Medicine Panel on Dietary Antioxidants and Related Compounds. Selenium. In: Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. National Academies Press (US): Washington (DC); 2000, pp 284\u2013319."},{"key":"429_CR36","first-page":"634","volume":"130","author":"KM Nair","year":"2009","unstructured":"Nair KM, Iyengar V. Iron content, bioavailability & factors affecting iron status of Indians. Indian J Med Res. 2009;130:634\u201345.","journal-title":"Indian J Med Res"},{"key":"429_CR37","first-page":"324","volume":"137","author":"S Kalasuramath","year":"2013","unstructured":"Kalasuramath S, Kurpad AV, Thankachan P. Effect of iron status on iron absorption in different habitual meals in young south Indian women. Indian J Med Res. 2013;137:324\u201330.","journal-title":"Indian J Med Res"},{"key":"429_CR38","volume-title":"Dietary guidelines for Indians\u2014a manual","author":"National Institute of Nutrition.","year":"2011","unstructured":"National Institute of Nutrition. Dietary guidelines for Indians\u2014a manual. Hyderabad, India: Indian Council of Medical Research; 2011."},{"key":"429_CR39","doi-asserted-by":"publisher","first-page":"2079S","DOI":"10.3945\/jn.110.123356","volume":"140","author":"E Becquey","year":"2010","unstructured":"Becquey E, Martin-Prevel Y. Micronutrient adequacy of women\u2019s diet in urban Burkina Faso is low. J Nutr. 2010;140:2079S\u20132085S.","journal-title":"J Nutr"},{"key":"429_CR40","doi-asserted-by":"publisher","first-page":"S87","DOI":"10.1079\/BJN2000299","volume":"85","author":"S Seshadri","year":"2001","unstructured":"Seshadri S. Prevalence of micronutrient deficiency particularly of iron, zinc and folic acid in pregnant women in South East Asia. Br J Nutr. 2001;85:S87\u2013S92.","journal-title":"Br J Nutr"},{"key":"429_CR41","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1017\/S0007114514000592","volume":"112","author":"S Henjum","year":"2014","unstructured":"Henjum S, Manger M, Skeie E, Ulak M, Thorne-Lyman AL, Chandyo R, et al. Iron deficiency is uncommon among lactating women in urban Nepal, despite a high risk of inadequate dietary iron intake. Br J Nutr. 2014;112:132\u201341.","journal-title":"Br J Nutr"},{"key":"429_CR42","first-page":"156","volume":"11","author":"S Songchitsomboon","year":"1998","unstructured":"Songchitsomboon S, Komindr S, Phuapradit W, Sirivarasai J. Zinc and copper status in urban Thai pregnant women and their pregnancy outcome. Biomed Environ Sci. 1998;11:156\u201364.","journal-title":"Biomed Environ Sci"},{"key":"429_CR43","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1017\/PHN2005921","volume":"9","author":"L Al Khatib","year":"2006","unstructured":"Al Khatib L, Obeid O, Sibai AM, Batal M, Adra N, Hwalla N. Folate deficiency is associated with nutritional anaemia in Lebanese women of childbearing age. Public Health Nutr. 2006;9:921\u20137.","journal-title":"Public Health Nutr"},{"key":"429_CR44","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1079\/BJN20051590","volume":"95","author":"T Thoradeniya","year":"2006","unstructured":"Thoradeniya T, Wickremasinghe R, Ramanayake R, Atukorala S. Low folic acid status and its association with anaemia in urban adolescent girls and women of childbearing age in Sri Lanka. Br J Nutr. 2006;95:511\u20136.","journal-title":"Br J Nutr"},{"key":"429_CR45","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1093\/ajcn\/80.5.1276","volume":"80","author":"K Alarcon","year":"2004","unstructured":"Alarcon K, Kolsteren PW, Prada AM, Chian AM, Velarde RE, Pecho IL, et al. Effects of separate delivery of zinc or zinc and vitamin A on hemoglobin response, growth, and diarrhea in young Peruvian children receiving iron therapy for anemia. Am J Clin Nutr. 2004;80:1276\u201382.","journal-title":"Am J Clin Nutr"},{"key":"429_CR46","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1093\/jn\/116.6.927","volume":"116","author":"NW Solomons","year":"1986","unstructured":"Solomons NW. Competitive interaction of iron and zinc in the diet\u2014consequences for human nutrition. J Nutr. 1986;116:927\u201335.","journal-title":"J Nutr"},{"key":"429_CR47","doi-asserted-by":"publisher","first-page":"442S","DOI":"10.1093\/ajcn\/68.2.442S","volume":"68","author":"P Whittaker","year":"1998","unstructured":"Whittaker P. Iron and zinc interactions in humans. Am J Clin Nutr. 1998;68:442S\u2013446S.","journal-title":"Am J Clin Nutr"},{"key":"429_CR48","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1159\/000371618","volume":"66","author":"RL Bailey","year":"2015","unstructured":"Bailey RL, West KP, Black RE. The epidemiology of global micronutrient deficiencies. Ann Nutr Metab. 2015;66:22\u201333.","journal-title":"Ann Nutr Metab"},{"key":"429_CR49","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1079\/PNS19950018","volume":"54","author":"MW Bloem","year":"1995","unstructured":"Bloem MW. Interdependence of vitamin A and iron\u2014an important association for programs of anaemia control. Proc Nutr Soc. 1995;54:501\u20138.","journal-title":"Proc Nutr Soc"},{"key":"429_CR50","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1093\/ajcn\/87.4.881","volume":"87","author":"P Thankachan","year":"2008","unstructured":"Thankachan P, Walczyk T, Muthayya S, Kurpad AV, Hurrell RF. Iron absorption in young Indian women: the interaction of iron status with the influence of tea and ascorbic acid. Am J Clin Nutr. 2008;87:881\u20136.","journal-title":"Am J Clin Nutr"},{"key":"429_CR51","doi-asserted-by":"publisher","first-page":"E366","DOI":"10.1016\/S2214-109X(15)00038-8","volume":"3","author":"CHD Fall","year":"2015","unstructured":"Fall CHD, Sachdev HS, Osmond C, Restrepo-Mendez MC, Victora C, Martorell R, et al. Association between maternal age at childbirth and child and adult outcomes in the off spring: a prospective study in five low-income and middle-income countries (COHORTS collaboration). Lancet Glob Health. 2015;3:E366\u2013E377.","journal-title":"Lancet Glob Health"},{"key":"429_CR52","volume-title":"Nutrition in India. National Family Health Survey (NFHS-3), India, 2005\u201306","author":"FPS Arnold","year":"2009","unstructured":"Arnold FPS, Arokiasamy P, Kothari M. Nutrition in India. National Family Health Survey (NFHS-3), India, 2005\u201306. Mumbai: International Institute for Population Sciences; Calverton, Maryland, USA: ICF Macro; 2009."},{"key":"429_CR53","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3945\/jn.112.169524","volume":"143","author":"JE Arsenault","year":"2013","unstructured":"Arsenault JE, Yakes EA, Islam MM, Hossain MB, Ahmed T, Hotz C, et al. Very low adequacy of micronutrient intakes by young children and women in rural Bangladesh is primarily explained by low food intake and limited diversity. J Nutr. 2013;143:197\u2013203.","journal-title":"J Nutr"},{"key":"429_CR54","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/S0140-6736(07)61692-4","volume":"371","author":"CG Victora","year":"2008","unstructured":"Victora CG, Adair L, Fall C, Hallal PC, Martorell R, Richter L, et al. Maternal and child undernutrition 2\u2014Maternal and child undernutrition: consequences for adult health and human capital. Lancet. 2008;371:340\u201357.","journal-title":"Lancet"},{"key":"429_CR55","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-12-126","volume":"12","author":"PH Nguyen","year":"2013","unstructured":"Nguyen PH, Strizich G, Lowe A, Nguyen H, Pham H, Truong TV, et al. Food consumption patterns and associated factors among Vietnamese women of reproductive age. Nutr J. 2013;12:11.","journal-title":"Nutr J"},{"issue":"Suppl 1","key":"429_CR56","first-page":"103","volume":"17","author":"LH Allen","year":"2008","unstructured":"Allen LH. To what extent can food-based approaches improve micronutrient status? Asia Pac J Clin Nutr. 2008;17(Suppl 1):103\u20135.","journal-title":"Asia Pac J Clin Nutr"},{"key":"429_CR57","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1177\/15648265110321S103","volume":"32","author":"HE Bouis","year":"2011","unstructured":"Bouis HE, Eozenou P, Rahman A. Food prices, household income, and resource allocation: socioeconomic perspectives on their effects on dietary quality and nutritional status. Food Nutr Bull. 2011;32:S14\u201323.","journal-title":"Food Nutr Bull"},{"key":"429_CR58","first-page":"29","volume-title":"2013 Global food policy report","author":"A Kishore","year":"2014","unstructured":"Kishore A, Hoddinott JF, Joshi PK. India\u2019s right to food act: a novel approach to food security. 2013 Global food policy report. Washington, DC: International Food Policy Research Institute (IFPRI); 2014. p. 29\u201342."},{"key":"429_CR59","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.3945\/ajcn.112.048462","volume":"97","author":"P Dominguez-Salas","year":"2013","unstructured":"Dominguez-Salas P, Moore SE, Cole D, da Costa KA, Cox SE, Dyer RA, et al. DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women. Am J Clin Nutr. 2013;97:1217\u201327.","journal-title":"Am J Clin Nutr"},{"key":"429_CR60","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4746","volume":"5","author":"P Dominguez-Salas","year":"2014","unstructured":"Dominguez-Salas P, Moore SE, Baker MS, Bergen AW, Cox SE, Dyer RA, et al. Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nat Commun. 2014;5:7.","journal-title":"Nat Commun"}],"container-title":["European Journal of Clinical Nutrition"],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41430-019-0429-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41430-019-0429-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41430-019-0429-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:38:28Z","timestamp":1684618708000},"score":9.736749,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41430-019-0429-6"}},"issued":{"date-parts":[[2019,5,31]]},"references-count":60,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["429"],"URL":"https:\/\/doi.org\/10.1038\/s41430-019-0429-6","ISSN":["0954-3007","1476-5640"],"issn-type":[{"value":"0954-3007","type":"print"},{"value":"1476-5640","type":"electronic"}],"published":{"date-parts":[[2019,5,31]]},"assertion":[{"value":"4 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]},{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:09:12Z","timestamp":1779887352806,"version":"3.53.1"},"reference-count":102,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["098387\/Z\/12\/Z"],"award-info":[{"award-number":["098387\/Z\/12\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["212284\/Z\/18\/Z"],"award-info":[{"award-number":["212284\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["109109\/Z\/15\/Z"],"award-info":[{"award-number":["109109\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["095552\/Z\/11\/Z"],"award-info":[{"award-number":["095552\/Z\/11\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"abstract":"\n During meiosis, homologous chromosomes pair and recombine, enabling balanced segregation and generating genetic diversity. In many vertebrates, double-strand breaks (DSBs) initiate recombination within hotspots where PRDM9 binds, and deposits H3K4me3 and H3K36me3. However, no protein(s) recognising this unique combination of histone marks have been identified. We identified\n Zcwpw1<\/jats:italic>\n , containing H3K4me3 and H3K36me3 recognition domains, as having highly correlated expression with\n Prdm9<\/jats:italic>\n . Here, we show that ZCWPW1 has co-evolved with PRDM9 and, in human cells, is strongly and specifically recruited to PRDM9 binding sites, with higher affinity than sites possessing H3K4me3 alone. Surprisingly, ZCWPW1 also recognises CpG dinucleotides. Male\n Zcwpw1<\/jats:italic>\n knockout mice show completely normal DSB positioning, but persistent DMC1 foci, severe DSB repair and synapsis defects, and downstream sterility. Our findings suggest ZCWPW1 recognition of PRDM9-bound sites at DSB hotspots is critical for synapsis, and hence fertility.\n <\/jats:p>","DOI":"10.7554\/elife.53392","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T08:00:39Z","timestamp":1596441639000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.53392","source":"Crossref","is-referenced-by-count":51,"title":["ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair"],"prefix":"10.7554","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-8978","authenticated-orcid":true,"given":"Daniel","family":"Wells","sequence":"first","affiliation":[{"name":"The Wellcome Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, United Kingdom"},{"name":"Department of Statistics, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3439-2113","authenticated-orcid":true,"given":"Emmanuelle","family":"Bitoun","sequence":"additional","affiliation":[{"name":"The Wellcome Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, United Kingdom"},{"name":"Department of Statistics, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Moralli","sequence":"additional","affiliation":[{"name":"The Wellcome Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Wellcome Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Hinch","sequence":"additional","affiliation":[{"name":"The Wellcome Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Jankowska","sequence":"additional","affiliation":[{"name":"The Wellcome Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Donnelly","sequence":"additional","affiliation":[{"name":"The Wellcome Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, United Kingdom"},{"name":"Department of Statistics, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Green","sequence":"additional","affiliation":[{"name":"The Wellcome Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2585-9626","authenticated-orcid":true,"given":"Simon R","family":"Myers","sequence":"additional","affiliation":[{"name":"The Wellcome Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, United Kingdom"},{"name":"Department of Statistics, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/BF00292841","article-title":"In vivo BrdU-33258 hoechst analysis of DNA replication kinetics and sister chromatid exchange formation in mouse somatic and meiotic cells","volume":"58","author":"Allen","year":"1976","journal-title":"Chromosoma"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28383","article-title":"A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis","volume":"6","author":"Altemose","year":"2017","journal-title":"eLife"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Research"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"5101","DOI":"10.1111\/j.1742-4658.2005.04945.x","article-title":"Protein database searches using compositionally adjusted substitution matrices","volume":"272","author":"Altschul","year":"2005","journal-title":"FEBS Journal"},{"key":"bib5","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1242\/jcs.114.4.685","article-title":"Localization of two mammalian cyclin dependent kinases during mammalian meiosis","volume":"114","author":"Ashley","year":"2001","journal-title":"Journal of Cell Science"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/nsmb.2796","article-title":"Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks","volume":"21","author":"Aymard","year":"2014","journal-title":"Nature Structural & Molecular Biology"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24133","article-title":"Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates","volume":"6","author":"Baker","year":"2017","journal-title":"eLife"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.ccell.2018.07.006","article-title":"The SS18-SSX oncoprotein hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma","volume":"34","author":"Banito","year":"2018","journal-title":"Cancer Cell"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000076","article-title":"ATM promotes the obligate XY crossover and both crossover control and chromosome Axis integrity on autosomes","volume":"4","author":"Barchi","year":"2008","journal-title":"PLOS Genetics"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","article-title":"High-resolution profiling of histone methylations in the human genome","volume":"129","author":"Barski","year":"2007","journal-title":"Cell"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1126\/science.1183439","article-title":"PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice","volume":"327","author":"Baudat","year":"2010","journal-title":"Science"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.14541.1","article-title":"drawProteins: a bioconductor\/R package for reproducible and programmatic generation of protein schematics","volume":"7","author":"Brennan","year":"2018","journal-title":"F1000Research"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/nature11089","article-title":"Genetic recombination is directed away from functional genomic elements in mice","volume":"485","author":"Brick","year":"2012","journal-title":"Nature"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005653","article-title":"Small Rad51 and Dmc1 complexes often Co-occupy both ends of a meiotic DNA double strand break","volume":"11","author":"Brown","year":"2015","journal-title":"PLOS Genetics"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s00412-019-00692-x","article-title":"Leagues of their own: sexually dimorphic features of meiotic prophase I","volume":"128","author":"Cahoon","year":"2019","journal-title":"Chromosoma"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006529","article-title":"A versatile viral system for expression and depletion of proteins in mammalian cells","volume":"4","author":"Campeau","year":"2009","journal-title":"PLOS ONE"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1093\/bioinformatics\/btm270","article-title":"Predicting functionally important residues from sequence conservation","volume":"23","author":"Capra","year":"2007","journal-title":"Bioinformatics"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1089\/bio.2015.0032","article-title":"A novel approach to High-Quality postmortem tissue procurement: the GTEx project","volume":"13","author":"Carithers","year":"2015","journal-title":"Biopreservation and Biobanking"},{"key":"bib19","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02482","article-title":"SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint","volume":"3","author":"Carvalho","year":"2014","journal-title":"eLife"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/7506976","article-title":"Noncoding centromeric RNA expression impairs chromosome stability in human and murine stem cells","volume":"2017","author":"Chan","year":"2017","journal-title":"Disease Markers"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/nature16931","article-title":"Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice","volume":"530","author":"Davies","year":"2016","journal-title":"Nature"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-12-236","article-title":"Alu elements: know the SINEs","volume":"12","author":"Deininger","year":"2011","journal-title":"Genome Biology"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.molcel.2018.01.033","article-title":"PRDM9 methyltransferase activity is essential for meiotic DNA Double-Strand break formation at its binding sites","volume":"69","author":"Diagouraga","year":"2018","journal-title":"Molecular Cell"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.devcel.2007.03.018","article-title":"SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice","volume":"12","author":"Ding","year":"2007","journal-title":"Developmental Cell"},{"key":"bib25","volume-title":"data.table: Extension of `data.frame`","author":"Dowle","year":"2019","unstructured":"Dowle M, Srinivasan A. 2019. data.table: Extension of `data.frame`."},{"key":"bib26","volume-title":"viridis: Default Color Maps from \u201cmatplotlib","author":"Garnier","year":"2018","unstructured":"Garnier S. 2018. viridis: Default Color Maps from \u201cmatplotlib."},{"key":"bib27","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/cyto.a.22463","article-title":"Optimized flow cytometry isolation of murine spermatocytes","volume":"85","author":"Gaysinskaya","year":"2014","journal-title":"Cytometry Part A"},{"key":"bib28","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-018-0186-0","article-title":"Transient reduction of DNA methylation at the onset of meiosis in male mice","volume":"11","author":"Gaysinskaya","year":"2018","journal-title":"Epigenetics & Chromatin"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1093\/bioinformatics\/btv153","article-title":"PRROC: computing and visualizing precision-recall and receiver operating characteristic curves in R","volume":"31","author":"Grau","year":"2015","journal-title":"Bioinformatics"},{"key":"bib30","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34282","article-title":"Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice","volume":"7","author":"Gregorova","year":"2018","journal-title":"eLife"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/nature04112","article-title":"A histone H3 methyltransferase controls epigenetic events required for meiotic prophase","volume":"438","author":"Hayashi","year":"2005","journal-title":"Nature"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.2210\/pdb2rr4\/pdb","article-title":"Complex structure of the zf-CW domain and the H3K4me3 peptide","volume":"18","author":"He","year":"2010","journal-title":"Structure"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.str.2010.06.012","article-title":"Structural insight into the zinc finger CW domain as a histone modification reader","volume":"18","author":"He","year":"2010","journal-title":"Structure"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1002\/dvdy.24183","article-title":"Poly peak parser: method and software for identification of unknown indels using Sanger sequencing of polymerase chain reaction products","volume":"243","author":"Hill","year":"2014","journal-title":"Developmental Dynamics"},{"key":"bib36","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau8861","article-title":"Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm","volume":"363","author":"Hinch","year":"2019","journal-title":"Science"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"41906","DOI":"10.1074\/jbc.M105563200","article-title":"Saccharomyces cerevisiae Dmc1 protein promotes renaturation of single-strand DNA (ssDNA) and assimilation of ssDNA into homologous super-coiled duplex DNA","volume":"276","author":"Hong","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1083\/jcb.201304004","article-title":"A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton","volume":"202","author":"Horn","year":"2013","journal-title":"The Journal of Cell Biology"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"7811","DOI":"10.1074\/jbc.RA118.002839","article-title":"H3K36me3-mediated mismatch repair preferentially protects actively transcribed genes from mutation","volume":"293","author":"Huang","year":"2018","journal-title":"Journal of Biological Chemistry"},{"key":"bib40","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53459","article-title":"The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair","volume":"9","author":"Huang","year":"2020","journal-title":"eLife"},{"key":"bib41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11282-x","article-title":"The histone methyltransferase Setd2 is indispensable for V(D)J recombination","volume":"10","author":"Ji","year":"2019","journal-title":"Nature Communications"},{"key":"bib42","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-388","article-title":"A comparative study of conservation and variation scores","volume":"11","author":"Johansson","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"bib43","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.43966","article-title":"Unified single-cell analysis of testis gene regulation and pathology in five mouse strains","volume":"8","author":"Jung","year":"2019","journal-title":"eLife"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1093\/bioinformatics\/btq351","article-title":"BigWig and BigBed: enabling browsing of large distributed datasets","volume":"26","author":"Kent","year":"2010","journal-title":"Bioinformatics"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1101\/gr.130583.111","article-title":"Sensitive mapping of recombination hotspots using sequencing-based detection of ssDNA","volume":"22","author":"Khil","year":"2012","journal-title":"Genome Research"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1093\/bioinformatics\/bts480","article-title":"Snakemake--a scalable bioinformatics workflow engine","volume":"28","author":"K\u00f6ster","year":"2012","journal-title":"Bioinformatics"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/s41580-019-0126-2","article-title":"Quality and quantity control of gene expression by nonsense-mediated mRNA decay","volume":"20","author":"Kurosaki","year":"2019","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.cell.2016.09.035","article-title":"The landscape of mouse meiotic Double-Strand break formation, processing, and repair","volume":"167","author":"Lange","year":"2016","journal-title":"Cell"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"41725","DOI":"10.1074\/jbc.M508312200","article-title":"CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1\/COMPASS complex","volume":"280","author":"Lee","year":"2005","journal-title":"Journal of Biological Chemistry"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1128\/MCB.01356-07","article-title":"Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes","volume":"28","author":"Lee","year":"2008","journal-title":"Molecular and Cellular Biology"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.cell.2013.03.025","article-title":"The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutS\u03b1","volume":"153","author":"Li","year":"2013","journal-title":"Cell"},{"key":"bib52","article-title":"Aligning sequence reads\u00a0clone sequences and assembly contigs with BWA-MEM","volume-title":"\u00a0arXiv","author":"Li","year":"2013","unstructured":"Li H. 2013. Aligning sequence reads\u00a0clone sequences and assembly contigs with BWA-MEM. \u00a0arXiv. https:\/\/arxiv.org\/abs\/1303.3997."},{"key":"bib53","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax1101","article-title":"The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice","volume":"5","author":"Li","year":"2019","journal-title":"Science Advances"},{"key":"bib54","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11675-y","article-title":"A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination","volume":"10","author":"Li","year":"2019","journal-title":"Nature Communications"},{"key":"bib55","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2015.00339","article-title":"Overexpression of the heterochromatinization factor BAHD1 in HEK293 cells differentially reshapes the DNA methylome on autosomes and X chromosome","volume":"6","author":"Libertini","year":"2015","journal-title":"Frontiers in Genetics"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"9000","DOI":"10.1074\/jbc.M116.718973","article-title":"Family-wide characterization of histone binding abilities of human CW Domain-containing proteins","volume":"291","author":"Liu","year":"2016","journal-title":"Journal of Biological Chemistry"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1093\/bioinformatics\/btp302","article-title":"pGenTHREADER and pDomTHREADER: new methods for improved protein fold recognition and superfamily discrimination","volume":"25","author":"Lobley","year":"2009","journal-title":"Bioinformatics"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1080\/15384101.2014.998070","article-title":"Double-strand break repair on sex chromosomes: challenges during male meiotic prophase","volume":"14","author":"Lu","year":"2015","journal-title":"Cell Cycle"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1101\/gr.111120.110","article-title":"Stampy: a statistical algorithm for sensitive and fast mapping of illumina sequence reads","volume":"21","author":"Lunter","year":"2011","journal-title":"Genome Research"},{"key":"bib60","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/784706","article-title":"Dynamic alu methylation during normal development, aging, and tumorigenesis","volume":"2014","author":"Luo","year":"2014","journal-title":"BioMed Research International"},{"key":"bib61","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53360","article-title":"Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice","volume":"9","author":"Mahgoub","year":"2020","journal-title":"eLife"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"W327","DOI":"10.1093\/nar\/gkh454","article-title":"CD-Search: protein domain annotations on the fly","volume":"32","author":"Marchler-Bauer","year":"2004","journal-title":"Nucleic Acids Research"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.1007\/s00018-017-2517-x","article-title":"Shaping the cellular landscape with Set2\/SETD2 methylation","volume":"74","author":"McDaniel","year":"2017","journal-title":"Cellular and Molecular Life Sciences"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1101\/gr.244426.118","article-title":"Histone methyltransferase PRDM9 is not essential for meiosis in male mice","volume":"29","author":"Mihola","year":"2019","journal-title":"Genome Research"},{"key":"bib65","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1242\/jcs.115.8.1611","article-title":"The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination","volume":"115","author":"Moens","year":"2002","journal-title":"Journal of Cell Science"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1530\/rep.1.00865","article-title":"Not all germ cells are created equal: aspects of sexual dimorphism in mammalian meiosis","volume":"130","author":"Morelli","year":"2005","journal-title":"Reproduction"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.molcel.2008.10.025","article-title":"CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation","volume":"32","author":"Mulligan","year":"2008","journal-title":"Molecular Cell"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1126\/science.1182363","article-title":"Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination","volume":"327","author":"Myers","year":"2010","journal-title":"Science"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nature04885","article-title":"Clarifying the mechanics of DNA strand exchange in meiotic recombination","volume":"442","author":"Neale","year":"2006","journal-title":"Nature"},{"key":"bib70","volume-title":"RColorBrewer: ColorBrewer Palettes","author":"Neuwirth","year":"2014","unstructured":"Neuwirth E. 2014. RColorBrewer: ColorBrewer Palettes."},{"key":"bib71","doi-asserted-by":"publisher","DOI":"10.1126\/science.1181495","article-title":"Prdm9 controls activation of mammalian recombination hotspots","volume":"327","author":"Parvanov","year":"2010","journal-title":"Science"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1091\/mbc.e16-09-0686","article-title":"PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal Axis in meiosis","volume":"28","author":"Parvanov","year":"2017","journal-title":"Molecular Biology of the Cell"},{"key":"bib73","volume-title":"ggforce: Accelerating \u201cggplot2","author":"Pedersen","year":"2016","unstructured":"Pedersen TL. 2016. ggforce: Accelerating \u201cggplot2."},{"key":"bib74","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1023\/a:1018445520117","article-title":"A drying-down technique for the spreading of mammalian meiocytes from the male and female germline","volume":"5","author":"Peters","year":"1997","journal-title":"Chromosome Research : An International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/S1534-5807(03)00369-1","article-title":"The Hop2 protein has a direct role in promoting interhomolog interactions during mouse meiosis","volume":"5","author":"Petukhova","year":"2003","journal-title":"Developmental Cell"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1016\/j.celrep.2014.05.026","article-title":"SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability","volume":"7","author":"Pfister","year":"2014","journal-title":"Cell Reports"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1093\/bioinformatics\/btu056","article-title":"Bwtool: a tool for bigWig files","volume":"30","author":"Pohl","year":"2014","journal-title":"Bioinformatics"},{"key":"bib78","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006146","article-title":"The meiotic recombination activator PRDM9 trimethylates both H3K36 and H3K4 at recombination hotspots in vivo","volume":"12","author":"Powers","year":"2016","journal-title":"PLOS Genetics"},{"key":"bib79","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256442","article-title":"DNA recombination recombination initiation maps of individual human genomes","volume":"346","author":"Pratto","year":"2014","journal-title":"Science"},{"key":"bib80","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.tibs.2014.09.001","article-title":"Structure and function of the nucleosome-binding PWWP domain","volume":"39","author":"Qin","year":"2014","journal-title":"Trends in Biochemical Sciences"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"bib82","article-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2018","unstructured":"R Development Core Team. 2018. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing. http:\/\/www.r-project.org."},{"key":"bib83","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s12551-015-0190-6","article-title":"PWWP domains and their modes of sensing DNA and histone methylated lysines","volume":"8","author":"Rona","year":"2016","journal-title":"Biophysical Reviews"},{"key":"bib84","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1101\/gad.973302","article-title":"SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins","volume":"16","author":"Schultz","year":"2002","journal-title":"Genes & Development"},{"key":"bib85","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature02563","article-title":"Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange","volume":"429","author":"Sehorn","year":"2004","journal-title":"Nature"},{"key":"bib86","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2011.0330","article-title":"Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers","volume":"368","author":"Seisenberger","year":"2013","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"key":"bib87","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163962","article-title":"SeqKit: a Cross-Platform and ultrafast toolkit for FASTA\/Q file manipulation","volume":"11","author":"Shen","year":"2016","journal-title":"PLOS ONE"},{"key":"bib88","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/ncb2896","article-title":"The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis","volume":"16","author":"Shibuya","year":"2014","journal-title":"Nature Cell Biology"},{"key":"bib89","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/nature09869","article-title":"Genome-wide analysis reveals novel molecular features of mouse recombination hotspots","volume":"472","author":"Smagulova","year":"2011","journal-title":"Nature"},{"key":"bib90","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005531","article-title":"A gene regulatory program for meiotic prophase in the fetal ovary","volume":"11","author":"Soh","year":"2015","journal-title":"PLOS Genetics"},{"key":"bib91","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1101\/gad.333542.119","article-title":"HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots","volume":"34","author":"Spruce","year":"2020","journal-title":"Genes & Development"},{"key":"bib92","volume-title":"GNU Parallel","author":"Tange","year":"2018","unstructured":"Tange O. 2018. GNU Parallel. http:\/\/Lulu.com."},{"key":"bib93","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1083\/jcb.147.2.207","article-title":"RAD51 and DMC1 form mixed complexes associated with mouse meiotic chromosome cores and synaptonemal complexes","volume":"147","author":"Tarsounas","year":"1999","journal-title":"Journal of Cell Biology"},{"key":"bib94","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1093\/bib\/bbs017","article-title":"Integrative genomics viewer (IGV): high-performance genomics data visualization and exploration","volume":"14","author":"Thorvaldsd\u00f3ttir","year":"2013","journal-title":"Briefings in Bioinformatics"},{"key":"bib95","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1073\/pnas.1618465114","article-title":"Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation","volume":"114","author":"Tu","year":"2017","journal-title":"PNAS"},{"key":"bib96","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419","article-title":"Proteomics Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"bib97","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nrm3274","article-title":"Understanding the language of Lys36 methylation at histone H3","volume":"13","author":"Wagner","year":"2012","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"bib98","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4","volume-title":"Ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"bib99","volume-title":"cowplot: Streamlined Plot Theme and Plot Annotations for \u201cggplot2.","author":"Wilke","year":"2018","unstructured":"Wilke CO. 2018. cowplot: Streamlined Plot Theme and Plot Annotations for \u201cggplot2."},{"key":"bib100","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1467-9868.2010.00749.x","article-title":"Fast stable restricted maximum likelihood and marginal likelihood estimation of semiparametric generalized linear models","volume":"73","author":"Wood","year":"2011","journal-title":"Journal of the Royal Statistical Society: Series B"},{"key":"bib101","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1093\/nar\/gkr017","article-title":"Genome-wide quantitative assessment of variation in DNA methylation patterns","volume":"39","author":"Xie","year":"2011","journal-title":"Nucleic Acids Research"},{"key":"bib102","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08676-2","article-title":"A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination","volume":"10","author":"Zhang","year":"2019","journal-title":"Nature Communications"}],"container-title":["eLife"],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/53392\/elife-53392-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/53392\/elife-53392-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/53392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:00:47Z","timestamp":1697058047000},"score":9.731461,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/53392"}},"issued":{"date-parts":[[2020,8,3]]},"references-count":102,"alternative-id":["10.7554\/eLife.53392"],"URL":"https:\/\/doi.org\/10.7554\/elife.53392","archive":["CLOCKSS"],"relation":{"references":[{"id-type":"accession","id":"GSE59836","asserted-by":"subject"},{"id-type":"accession","id":"GSE73833","asserted-by":"subject"},{"id-type":"accession","id":"GSE84689","asserted-by":"subject"},{"id-type":"accession","id":"GSE35498","asserted-by":"subject"},{"id-type":"accession","id":"GSE99407","asserted-by":"subject"},{"id-type":"accession","id":"GSE51867","asserted-by":"subject"}],"is-supplemented-by":[{"id-type":"accession","id":"GSE141516","asserted-by":"subject"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/821678","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.53392.sa2","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.53392.sa1","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"published":{"date-parts":[[2020,8,3]]},"article-number":"e53392"},{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:32:31Z","timestamp":1777984351279,"version":"3.51.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214280\/Z\/18\/Z"],"award-info":[{"award-number":["214280\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214280\/Z\/18\/Z"],"award-info":[{"award-number":["214280\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214280\/Z\/18\/Z"],"award-info":[{"award-number":["214280\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214280\/Z\/18\/Z"],"award-info":[{"award-number":["214280\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214280\/Z\/18\/Z"],"award-info":[{"award-number":["214280\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214280\/Z\/18\/Z"],"award-info":[{"award-number":["214280\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214280\/Z\/18\/Z"],"award-info":[{"award-number":["214280\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214280\/Z\/18\/Z"],"award-info":[{"award-number":["214280\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214280\/Z\/18\/Z"],"award-info":[{"award-number":["214280\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214280\/Z\/18\/Z"],"award-info":[{"award-number":["214280\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214280\/Z\/18\/Z"],"award-info":[{"award-number":["214280\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214280\/Z\/18\/Z"],"award-info":[{"award-number":["214280\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214280\/Z\/18\/Z"],"award-info":[{"award-number":["214280\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214280\/Z\/18\/Z"],"award-info":[{"award-number":["214280\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214280\/Z\/18\/Z"],"award-info":[{"award-number":["214280\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Health Serv Res"],"DOI":"10.1186\/s12913-026-14137-6","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T05:17:11Z","timestamp":1770441431000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u201cWe carried her in a wheelbarrow to the clinic\u201d: process evaluation of the AMETHIST intervention combining microplanning with self-help groups to improve HIV prevention and treatment among female sex workers in Zimbabwe"],"prefix":"10.1186","volume":"26","author":[{"given":"Fortunate","family":"Machingura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gracious","family":"Madimutsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Memory","family":"Makamba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatenda","family":"Kujeke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Takaruza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaspar","family":"Maguma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanni","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungai T.","family":"Chabata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Primrose","family":"Matambanadzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Steen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Shahmanesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amon","family":"Mpofu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen","family":"Mugurungi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew N.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Hargreaves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances M.","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Busza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"issue":"S3","key":"14137_CR1","doi-asserted-by":"publisher","first-page":"e25716","DOI":"10.1002\/jia2.25716","volume":"24","author":"H Jin","year":"2021","unstructured":"Jin H, Restar A, Beyrer C. Overview of the epidemiological conditions of HIV among key populations in Africa. J Int AIDS Soc. 2021;24(S3):e25716.","journal-title":"J Int AIDS Soc"},{"issue":"10148","key":"14137_CR2","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/S0140-6736(18)31439-9","volume":"392","author":"K Shannon","year":"2018","unstructured":"Shannon K, Crago A-L, Baral SD, Bekker L-G, Kerrigan D, Decker MR, et al. The global response and unmet actions for HIV and sex workers. Lancet. 2018;392(10148):698\u2013710.","journal-title":"Lancet"},{"issue":"9963","key":"14137_CR3","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/S0140-6736(14)60973-9","volume":"385","author":"D Kerrigan","year":"2015","unstructured":"Kerrigan D, Kennedy CE, Morgan-Thomas R, Reza-Paul S, Mwangi P, Win KT, et al. A community empowerment approach to the HIV response among sex workers: effectiveness, challenges, and considerations for implementation and scale-up. Lancet. 2015;385(9963):172\u201385.","journal-title":"Lancet"},{"issue":"8","key":"14137_CR4","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1097\/OLQ.0000000000001020","volume":"46","author":"S Reza-Paul","year":"2019","unstructured":"Reza-Paul S, Steen R, Maiya R, Lorway R, Wi TE, Wheeler T, et al. Sex worker Community-led interventions interrupt sexually transmitted Infection\/Human immunodeficiency virus transmission and improve human immunodeficiency virus cascade outcomes: A program review from South India. Sex Transm Dis. 2019;46(8):556\u201362.","journal-title":"Sex Transm Dis"},{"issue":"4","key":"14137_CR5","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1007\/s10461-021-03481-9","volume":"26","author":"G Young","year":"2022","unstructured":"Young G, Danner MJE, Fort L, Blankenship KM. Community mobilization challenging gender power imbalances: women sex workers\u2019 capacity to engage in Health-Enhancing practices in Southern India. AIDS Behav. 2022;26(4):1238\u201350.","journal-title":"AIDS Behav"},{"issue":"3","key":"14137_CR6","doi-asserted-by":"publisher","first-page":"e0194301","DOI":"10.1371\/journal.pone.0194301","volume":"13","author":"T Chiyaka","year":"2018","unstructured":"Chiyaka T, Mushati P, Hensen B, Chabata S, Hargreaves JR, Floyd S, et al. Reaching young women who sell sex: methods and results of social mapping to describe and identify young women for DREAMS impact evaluation in Zimbabwe. PLoS ONE. 2018;13(3):e0194301.","journal-title":"PLoS ONE"},{"issue":"1","key":"14137_CR7","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/s12889-018-5085-6","volume":"18","author":"B Hensen","year":"2018","unstructured":"Hensen B, Hargreaves JR, Chiyaka T, Chabata S, Mushati P, Floyd S, et al. Evaluating the impact of DREAMS on HIV incidence among young women who sell sex: protocol for a non-randomised study in Zimbabwe. BMC Public Health. 2018;18(1):203.","journal-title":"BMC Public Health"},{"issue":"2","key":"14137_CR8","doi-asserted-by":"publisher","first-page":"85","DOI":"10.2471\/BLT.20.260224","volume":"99","author":"CR Mackworth-Young","year":"2021","unstructured":"Mackworth-Young CR, Chingono R, Mavodza C, McHugh G, Tembo M, Chikwari CD, et al. Community perspectives on the COVID-19 response, Zimbabwe. Bull World Health Organ. 2021;99(2):85\u201391.","journal-title":"Bull World Health Organ"},{"issue":"Suppl 5","key":"14137_CR9","doi-asserted-by":"publisher","first-page":"e25138","DOI":"10.1002\/jia2.25138","volume":"21","author":"T Ndori-Mharadze","year":"2018","unstructured":"Ndori-Mharadze T, Fearon E, Busza J, Dirawo J, Musemburi S, Davey C, et al. Changes in engagement in HIV prevention and care services among female sex workers during intensified community mobilization in 3 sites in Zimbabwe, 2011 to 2015. J Int AIDS Soc. 2018;21(Suppl 5):e25138.","journal-title":"J Int AIDS Soc"},{"issue":"8","key":"14137_CR10","doi-asserted-by":"publisher","first-page":"e417","DOI":"10.1016\/S2352-3018(18)30111-5","volume":"5","author":"FM Cowan","year":"2018","unstructured":"Cowan FM, Davey C, Fearon E, Mushati P, Dirawo J, Chabata S, et al. Targeted combination prevention to support female sex workers in Zimbabwe accessing and adhering to antiretrovirals for treatment and prevention of HIV (SAPPH-IRe): a cluster-randomised trial. Lancet HIV. 2018;5(8):e417\u201326.","journal-title":"Lancet HIV"},{"issue":"Suppl 4","key":"14137_CR11","doi-asserted-by":"publisher","first-page":"e25320","DOI":"10.1002\/jia2.25320","volume":"22","author":"FM Cowan","year":"2019","unstructured":"Cowan FM, Chabata ST, Musemburi S, Fearon E, Davey C, Ndori-Mharadze T, et al. Strengthening the scale-up and uptake of effective interventions for sex workers for population impact in Zimbabwe. J Int AIDS Soc. 2019;22(Suppl 4):e25320.","journal-title":"J Int AIDS Soc"},{"issue":"1","key":"14137_CR12","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s13063-022-06119-w","volume":"23","author":"FM Cowan","year":"2022","unstructured":"Cowan FM, Machingura F, Chabata ST, Ali MS, Busza J, Steen R, et al. Differentiated prevention and care to reduce the risk of HIV acquisition and transmission among female sex workers in zimbabwe: study protocol for the \u2018AMETHIST\u2019 cluster randomised trial. Trials. 2022;23(1):209.","journal-title":"Trials"},{"key":"14137_CR13","unstructured":"Cowan FM, Machingura F, Ali S, Chabata S, Takura A, Bansi-Matharu L. Cluster randomised trial of risk-differentiated care for female sex workers: AMETHIST. In: Conference on Retroviruses and Opportunistic Infections (CROI); 2023 Feb 19\u201322; Seattle, WA, USA. Seattle (WA): CROI; 2023. p. Oral Abstract Session 03."},{"key":"14137_CR14","doi-asserted-by":"crossref","unstructured":"Busza J, Chiyaka T, Musemburi S, Fearon E, Davey C, Chabata S, et al. Enhancing national prevention and treatment services for sex workers in Zimbabwe: a process evaluation of the SAPPH-IRe trial. Health Policy Plan. 2019.","DOI":"10.1093\/heapol\/czz037"},{"issue":"1","key":"14137_CR15","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1097\/QAI.0000000000001980","volume":"81","author":"E Fearon","year":"2019","unstructured":"Fearon E, Phillips A, Mtetwa S, Chabata ST, Mushati P, Cambiano V, et al. How can programs better support female sex workers to avoid HIV infection in zimbabwe? A prevention cascade analysis. J Acquir Immune Defic Syndr. 2019;81(1):24\u201335.","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"6","key":"14137_CR16","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1080\/09540121.2020.1832192","volume":"33","author":"J Busza","year":"2020","unstructured":"Busza J, Phillips AN, Mushati P, Chiyaka T, Magutshwa S, Musemburi S, et al. Understanding early uptake of PrEP by female sex workers in Zimbabwe. AIDS Care. 2020;33(6):729\u201335.","journal-title":"AIDS Care"},{"key":"14137_CR17","volume-title":"Building partnerships on HIV and sex work","author":"APNSW","year":"2011","unstructured":"APNSW. Building partnerships on HIV and sex work. Bangkok: Asia Pacific Network of Sex Workers; 2011."},{"issue":"6","key":"14137_CR18","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1007\/s10461-013-0458-4","volume":"17","author":"DL Kerrigan","year":"2013","unstructured":"Kerrigan DL, Fonner VA, Stromdahl S, Kennedy CE. Community empowerment among female sex workers is an effective HIV prevention intervention: a systematic review of the peer-reviewed evidence from low- and middle-income countries. AIDS Behav. 2013;17(6):1926\u201340.","journal-title":"AIDS Behav"},{"issue":"2","key":"14137_CR19","doi-asserted-by":"publisher","first-page":"104","DOI":"10.4103\/2224-3151.294302","volume":"9","author":"S Reza-Paul","year":"2020","unstructured":"Reza-Paul S, Lazarus L, Haldar P, Reza Paul M, Lakshmi B, Ramaiah M, et al. Community action for people with HIV and sex workers during the COVID-19 pandemic in India. WHO South East Asia J Public Health. 2020;9(2):104\u20136.","journal-title":"WHO South East Asia J Public Health"},{"issue":"11","key":"14137_CR20","doi-asserted-by":"publisher","first-page":"e0205056","DOI":"10.1371\/journal.pone.0205056","volume":"13","author":"P Bhattacharjee","year":"2018","unstructured":"Bhattacharjee P, Musyoki H, Prakash R, Malaba S, Dallabetta G, Wheeler T, et al. Micro-planning at scale with key populations in kenya: optimising peer educator ratios for programme outreach and HIV\/STI service utilisation. PLoS ONE. 2018;13(11):e0205056\u2013e.","journal-title":"PLoS ONE"},{"key":"14137_CR21","doi-asserted-by":"crossref","unstructured":"Brody C, de Hoop T, Vojtkova M, Warnock R, Dunbar M, Murthy P, et al. Economic self-help group programs for improving women\u2019s empowerment: a systematic review. Campbell Syst Reviews. 2015;19.","DOI":"10.4073\/csr.2015.19"},{"issue":"Suppl 1","key":"14137_CR22","doi-asserted-by":"publisher","first-page":"S102","DOI":"10.1080\/09540120500121185","volume":"17","author":"CA Latkin","year":"2005","unstructured":"Latkin CA, Knowlton AR. Micro-social structural approaches to HIV prevention: a social ecological perspective. AIDS Care. 2005;17(Suppl 1):S102\u201313.","journal-title":"AIDS Care"},{"issue":"9879","key":"14137_CR23","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/S0140-6736(13)60685-6","volume":"381","author":"A Prost","year":"2013","unstructured":"Prost A, Colbourn T, Seward N, Azad K, Coomarasamy A, Copas A, et al. Women\u2019s groups practising participatory learning and action to improve maternal and newborn health in low-resource settings: a systematic review and meta-analysis. Lancet. 2013;381(9879):1736\u201346.","journal-title":"Lancet"},{"issue":"1","key":"14137_CR24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/her\/cyp054","volume":"25","author":"J Hargreaves","year":"2010","unstructured":"Hargreaves J, Hatcher A, Strange V, Phetla G, Busza J, Kim J, et al. Process evaluation of the intervention with microfinance for AIDS and gender equity (IMAGE) in rural South Africa. Health Educ Res. 2010;25(1):27\u201340.","journal-title":"Health Educ Res"},{"key":"14137_CR25","doi-asserted-by":"publisher","first-page":"98","DOI":"10.4103\/0971-5916.93431","volume":"135","author":"S Reza-Paul","year":"2012","unstructured":"Reza-Paul S, Lorway R, O\u2019Brien N, Lazarus L, Jain J, Bhagya M, et al. Sex worker-led structural interventions in india: a case study on addressing violence in HIV prevention through the Ashodaya samithi collective in Mysore. Indian J Med Res. 2012;135:98\u2013106.","journal-title":"Indian J Med Res"},{"issue":"1","key":"14137_CR26","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1046\/j.1365-2648.1997.1997025095.x","volume":"25","author":"CP Langford","year":"1997","unstructured":"Langford CP, Bowsher J, Maloney JP, Lillis PP. Social support: a conceptual analysis. J Adv Nurs. 1997;25(1):95\u2013100.","journal-title":"J Adv Nurs"},{"issue":"2","key":"14137_CR27","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s10461-013-0561-6","volume":"18","author":"S Qiao","year":"2014","unstructured":"Qiao S, Li X, Stanton B. Social support and HIV-related risk behaviors: A systematic review of the global literature. AIDS Behav. 2014;18(2):419\u201341.","journal-title":"AIDS Behav"},{"key":"14137_CR28","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.socscimed.2016.05.012","volume":"159","author":"MA Carrasco","year":"2016","unstructured":"Carrasco MA, Bilal U. A sign of the times: to have or to be? Social capital or social cohesion? Soc Sci Med. 2016;159:127\u201331.","journal-title":"Soc Sci Med"},{"issue":"1","key":"14137_CR29","doi-asserted-by":"publisher","first-page":"e87527","DOI":"10.1371\/journal.pone.0087527","volume":"9","author":"VA Fonner","year":"2014","unstructured":"Fonner VA, Kerrigan D, Mnisi Z, Ketende S, Kennedy CE, Baral S. Social Cohesion, social Participation, and HIV related risk among female sex workers in Swaziland. PLoS ONE. 2014;9(1):e87527.","journal-title":"PLoS ONE"},{"issue":"6","key":"14137_CR30","doi-asserted-by":"publisher","first-page":"e001972","DOI":"10.1136\/bmjgh-2019-001972","volume":"4","author":"L Gram","year":"2019","unstructured":"Gram L, Fitchett A, Ashraf A, Daruwalla N, Osrin D. Promoting women\u2019s and children\u2019s health through community groups in low-income and middle-income countries: a mixed-methods systematic review of mechanisms, enablers and barriers. BMJ Glob Health. 2019;4(6):e001972.","journal-title":"BMJ Glob Health"},{"key":"14137_CR31","doi-asserted-by":"publisher","first-page":"h1258","DOI":"10.1136\/bmj.h1258","volume":"350","author":"GF Moore","year":"2015","unstructured":"Moore GF, Audrey S, Barker M, Bond L, Bonell C, Hardeman W, et al. Process evaluation of complex interventions: medical research Council guidance. BMJ. 2015;350:h1258.","journal-title":"BMJ"},{"key":"14137_CR32","doi-asserted-by":"publisher","first-page":"101172","DOI":"10.1016\/j.eclinm.2021.101172","volume":"41","author":"A Fryatt","year":"2021","unstructured":"Fryatt A, Simms V, Bandason T, Redzo N, Olaru ID, Ndhlovu CE, et al. Community SARS-CoV-2 Seroprevalence before and after the second wave of SARS-CoV-2 infection in Harare. Zimbabwe eClinicalMedicine. 2021;41:101172.","journal-title":"Zimbabwe eClinicalMedicine"},{"issue":"11","key":"14137_CR33","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1097\/QAD.0000000000002943","volume":"35","author":"F Machingura","year":"2021","unstructured":"Machingura F, Chabata ST, Busza J, Jamali G, Makamba M, Dirawo J, et al. Potential reduction in female sex workers\u2019 risk of contracting HIV during coronavirus disease 2019. Aids. 2021;35(11):1871\u20132.","journal-title":"Aids"},{"issue":"S6","key":"14137_CR34","doi-asserted-by":"publisher","first-page":"e25813","DOI":"10.1002\/jia2.25813","volume":"24","author":"P Matambanadzo","year":"2021","unstructured":"Matambanadzo P, Busza J, Mafaune H, Chinyanganya L, Machingura F, Ncube G, et al. It went through the roof: an observation study exploring the rise in PrEP uptake among Zimbabwean female sex workers in response to adaptations during Covid-19. J Int AIDS Soc. 2021;24(S6):e25813.","journal-title":"J Int AIDS Soc"},{"issue":"1","key":"14137_CR35","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1016\/S2352-3018(20)30334-9","volume":"8","author":"L Hans","year":"2021","unstructured":"Hans L, Hong SY, Ashipala LSN, Bikinesi L, Hamunime N, Kamangu JWN, et al. Maintaining ART services during COVID-19 border closures: lessons learned in Namibia. Lancet HIV. 2021;8(1):e7.","journal-title":"Lancet HIV"},{"issue":"6","key":"14137_CR36","doi-asserted-by":"publisher","first-page":"e373","DOI":"10.1016\/S2352-3018(20)30143-0","volume":"7","author":"HIV The Lancet","year":"2020","unstructured":"The Lancet HIV. Lockdown fears for key populations. Lancet HIV. 2020;7(6):e373.","journal-title":"Lancet HIV"},{"issue":"10","key":"14137_CR37","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1080\/17441692.2020.1810298","volume":"15","author":"S Gichuna","year":"2020","unstructured":"Gichuna S, Hassan R, Sanders T, Campbell R, Mutonyi M, Mwangi P. Access to healthcare in a time of COVID-19: sex workers in crisis in Nairobi, Kenya. Glob Public Health. 2020;15(10):1430\u201342.","journal-title":"Glob Public Health"},{"issue":"8","key":"14137_CR38","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1007\/s10508-020-01849-x","volume":"49","author":"R Singer","year":"2020","unstructured":"Singer R, Crooks N, Johnson AK, Lutnick A, Matthews A. COVID-19 prevention and protecting sex workers: A call to action. Arch Sex Behav. 2020;49(8):2739\u201341.","journal-title":"Arch Sex Behav"},{"issue":"10243","key":"14137_CR39","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0140-6736(20)31033-3","volume":"396","author":"L Platt","year":"2020","unstructured":"Platt L, Elmes J, Stevenson L, Holt V, Rolles S, Stuart R. Sex workers must not be forgotten in the COVID-19 response. Lancet (London England). 2020;396(10243):9\u201311.","journal-title":"Lancet (London England)"},{"issue":"7","key":"14137_CR40","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1080\/17441692.2020.1770831","volume":"15","author":"J Kimani","year":"2020","unstructured":"Kimani J, Adhiambo J, Kasiba R, Mwangi P, Were V, Mathenge J, et al. The effects of COVID-19 on the health and socio-economic security of sex workers in Nairobi, kenya: emerging intersections with HIV. Glob Public Health. 2020;15(7):1073\u201382.","journal-title":"Glob Public Health"},{"key":"14137_CR41","doi-asserted-by":"crossref","unstructured":"Tura HT, Story WT, Licoze A. Community-based savings groups, women\u2019s agency, and maternal health service utilisation: evidence from Mozambique. Glob Public Health. 2020:1\u201311.","DOI":"10.1080\/17441692.2020.1751232"},{"issue":"9","key":"14137_CR42","doi-asserted-by":"publisher","first-page":"e1004097","DOI":"10.1371\/journal.pmed.1004097","volume":"19","author":"JD Tapsoba","year":"2022","unstructured":"Tapsoba JD, Cover J, Obong\u2019o C, Brady M, Cressey TR, Mori K, et al. Continued attendance in a PrEP program despite low adherence and non-protective drug levels among adolescent girls and young women in kenya: results from a prospective cohort study. PLoS Med. 2022;19(9):e1004097.","journal-title":"PLoS Med"},{"issue":"7","key":"14137_CR43","doi-asserted-by":"publisher","first-page":"e25963","DOI":"10.1002\/jia2.25963","volume":"25","author":"H-MA Schmidt","year":"2022","unstructured":"Schmidt H-MA, Rodolph M, Schaefer R, Baggaley R, Doherty M. Long-acting injectable cabotegravir: implementation science needed to advance this additional HIV prevention choice. J Int AIDS Soc. 2022;25(7):e25963.","journal-title":"J Int AIDS Soc"},{"issue":"1","key":"14137_CR44","doi-asserted-by":"publisher","first-page":"2040151","DOI":"10.1080\/16549716.2022.2040151","volume":"15","author":"R Chingono","year":"2022","unstructured":"Chingono R, Kasese C, Miles S, Busza J. I was in need of somewhere to release my hurt:\u2019 addressing the mental health of vulnerable adolescent mothers in Harare, Zimbabwe, through self-help groups. Glob Health Action. 2022;15(1):2040151.","journal-title":"Glob Health Action"},{"key":"14137_CR45","doi-asserted-by":"crossref","unstructured":"Hargreaves J, Busza J, Mushati P, Fearon E, Cowan F. Overlapping HIV and sex-work stigma among female sex-workers recruited to 14 respondent-driven sampling surveys across Zimbabwe. 2013. AIDS Care. 2017;In press.","DOI":"10.1080\/09540121.2016.1268673"},{"key":"14137_CR46","doi-asserted-by":"crossref","unstructured":"Steen R, Hontelez JAC, Mugurungi O, Mpofu A, Matthijsse SM, de Vlas SJ et al. Economy, migrant labour and sex work: interplay of HIV epidemic drivers in Zimbabwe over three decades. AIDS. 2019;33(1).","DOI":"10.1097\/QAD.0000000000002066"},{"key":"14137_CR47","doi-asserted-by":"publisher","first-page":"113597","DOI":"10.1016\/j.socscimed.2020.113597","volume":"270","author":"TL Crankshaw","year":"2021","unstructured":"Crankshaw TL, Chareka S, Zambezi P, Poku NK. Age matters: determinants of sexual and reproductive health vulnerabilities amongst young women who sell sex (16\u201324 years) in Zimbabwe. Soc Sci Med. 2021;270:113597.","journal-title":"Soc Sci Med"},{"issue":"S3","key":"14137_CR48","doi-asserted-by":"publisher","first-page":"e25512","DOI":"10.1002\/jia2.25512","volume":"23","author":"ST Chabata","year":"2020","unstructured":"Chabata ST, Hensen B, Chiyaka T, Mushati P, Busza J, Floyd S, et al. Condom use among young women who sell sex in zimbabwe: a prevention cascade analysis to identify gaps in HIV prevention programming. J Int AIDS Soc. 2020;23(S3):e25512.","journal-title":"J Int AIDS Soc"},{"issue":"12","key":"14137_CR49","doi-asserted-by":"publisher","first-page":"e25410","DOI":"10.1002\/jia2.25410","volume":"22","author":"B Hensen","year":"2019","unstructured":"Hensen B, Chabata ST, Floyd S, Chiyaka T, Mushati P, Busza J, et al. HIV risk among young women who sell sex by whether they identify as sex workers: analysis of respondent-driven sampling surveys, Zimbabwe, 2017. J Int AIDS Soc. 2019;22(12):e25410\u2013e.","journal-title":"J Int AIDS Soc"},{"issue":"3","key":"14137_CR50","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1097\/QAI.0000000000001815","volume":"79","author":"S Napierala","year":"2018","unstructured":"Napierala S, Chabata ST, Fearon E, Davey C, Hargreaves J, Busza J, et al. Engagement in HIV care among young female sex workers in Zimbabwe. J Acquir Immune Defic Syndr. 2018;79(3):358\u201366.","journal-title":"J Acquir Immune Defic Syndr"}],"container-title":["BMC Health Services Research"],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12913-026-14137-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12913-026-14137-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12913-026-14137-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:02:07Z","timestamp":1772820127000},"score":9.729992,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12913-026-14137-6"}},"issued":{"date-parts":[[2026,2,7]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["14137"],"URL":"https:\/\/doi.org\/10.1186\/s12913-026-14137-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4341475\/v1","asserted-by":"object"}]},"ISSN":["1472-6963"],"issn-type":[{"value":"1472-6963","type":"electronic"}],"published":{"date-parts":[[2026,2,7]]},"assertion":[{"value":"29 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was granted by the Medical Research Council of Zimbabwe (MRCZ\/A\/2559), the Liverpool School of Tropical Medicine (Ref 19-115RS), the London School of Hygiene and Tropical Medicine (ref:19123) the UK. Written informed consent from participants was obtained before enrolment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"334"},{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:06:26Z","timestamp":1777662386859,"version":"3.51.4"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205177\/Z\/16\/Z"],"award-info":[{"award-number":["205177\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"Abstract<\/jats:title>\n Urbanization results in increased numbers of people living in cities and poses challenges and opportunities to public health policies. Studies of urban scaling have unveiled how cities\u2019 socio-economic and infrastructural attributes vary systematically with city size. Previous studies have explored the scaling properties of health outcomes across metropolitan areas in different countries, but chronic diseases have been infrequently examined. This paper examines scaling behaviors of 4 cardiovascular risk factors: hypertension, diabetes, tobacco smoking, and obesity across 230 cities in six countries of Latin America. In analyses pooled across countries, diabetes and hypertension showed weakly superlinear scaling (higher prevalence in larger cities). In comparison, obesity showed linear scaling, and tobacco showed weakly sublinear scaling (lower prevalence in larger cities), although most coefficients did not differ significantly from the null. In country-specific analyses, hypertension and diabetes tended to show a superlinear pattern across most countries, obesity tended to show a sublinear pattern in most countries, and tobacco tended to be superlinear (in contrast to the analysis pooled across countries where it was sublinear). Results suggest the need to examine further the drivers of this varying scaling of risk factors.<\/jats:p>","DOI":"10.1038\/s41598-025-92087-5","type":"journal-article","created":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T08:45:51Z","timestamp":1740818751000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Scaling of cardiovascular risk factors in 230 Latin American cities"],"prefix":"10.1038","volume":"15","author":[{"given":"Aureliano S. S.","family":"Paiva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usama","family":"Bilal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto F. S.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiano C. Cruz","family":"Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Firmino","family":"de Sousa Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerv\u00e1sio F.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio L.","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pricila","family":"Mullachery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brisa","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana V.","family":"Diez-Roux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Montes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Trotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Alfaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Jaime","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonatiuh","family":"Barrientos-Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,1]]},"reference":[{"key":"92087_CR1","unstructured":"UN-Habitat. Urbanization and Development: Emerging Futures. World Cities Report 2016 264 (United Nations, 2016)."},{"key":"92087_CR2","unstructured":"United Nations. World Urbanization Prospects: The 2018 Revision (United Nations, 2019)."},{"key":"92087_CR3","doi-asserted-by":"publisher","first-page":"e111015","DOI":"10.1371\/journal.pone.0111015","volume":"9","author":"FJ Antonio","year":"2014","unstructured":"Antonio, F. J., De Piccoli, S., Teixeira, J. J. V. & Mendes, R. D. S. Growth patterns and scaling laws governing AIDS epidemic in Brazilian cities. PLoS ONE 9, e111015 (2014).","journal-title":"PLoS ONE"},{"key":"92087_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15517\/es.2023.55397","volume":"1","author":"O Patterson-Lomba","year":"2023","unstructured":"Patterson-Lomba, O. & Gomez-Lievano, A. On the scaling patterns of infectious disease incidence in cities. Epi. Sci. 1, 1 (2023).","journal-title":"Epi. Sci."},{"key":"92087_CR5","doi-asserted-by":"publisher","first-page":"e0293518","DOI":"10.1371\/journal.pone.0293518","volume":"18","author":"ASS Paiva","year":"2023","unstructured":"Paiva, A. S. S. et al. A scaling investigation of urban form features in Latin America cities. PLoS ONE 18, e0293518 (2023).","journal-title":"PLoS ONE"},{"key":"92087_CR6","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1126\/science.1235823","volume":"340","author":"LM Bettencourt","year":"2013","unstructured":"Bettencourt, L. M. A. The origins of scaling in cities. Science 340, 1438\u20131441 (2013).","journal-title":"Science"},{"key":"92087_CR7","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1080\/15389588.2016.1162904","volume":"17","author":"YS Chang","year":"2016","unstructured":"Chang, Y. S., Lee, W. J. & Lee, J. H. Are there higher pedestrian fatalities in larger cities? A scaling analysis of 115 to 161 largest cities in the united States. Traffic Inj. Prev. 17, 720\u2013728 (2016).","journal-title":"Traffic Inj. Prev."},{"key":"92087_CR8","doi-asserted-by":"publisher","first-page":"e0183110","DOI":"10.1371\/journal.pone.0183110","volume":"12","author":"M Oliveira","year":"2017","unstructured":"Oliveira, M., Bastos-Filho, C. & Menezes, R. The scaling of crime concentration in cities. PLoS ONE 12, e0183110 (2017).","journal-title":"PLoS ONE"},{"key":"92087_CR9","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s11524-021-00577-4","volume":"99","author":"EM McCulley","year":"2022","unstructured":"McCulley, E. M. et al. Urban scaling of health outcomes: a scoping review. J. Urban Health 99, 409\u2013426 (2022).","journal-title":"J. Urban Health"},{"key":"92087_CR10","unstructured":"Choi, S. B., Lee, Y. J. & Chang, Y. S. Population Size and Urban Health Advantage: Scaling Analyses of Four Major Diseases for 417 US Counties."},{"key":"92087_CR11","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1016\/S0140-6736(15)60901-1","volume":"386","author":"S Whitmee","year":"2015","unstructured":"Whitmee, S. et al. Safeguarding human health in the anthropocene epoch: report of the rockefeller Foundation\u2013Lancet commission on planetary health. Lancet 386, 1973\u20132028 (2015).","journal-title":"Lancet"},{"key":"92087_CR12","unstructured":"West, G. B. Scale: the Universal Laws of Growth, Innovation, Sustainability, and the Pace of Life in Organisms, Cities, Economies, and Companies (Penguin, 2017)."},{"key":"92087_CR13","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/35001159","volume":"403","author":"V Smil","year":"2000","unstructured":"Smil, V. Laying down the low: every living thing obeys the rules of scaling discovered by max Kleiber. Nature 403, 597\u2013598 (2000).","journal-title":"Nature"},{"key":"92087_CR14","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/421713a","volume":"421","author":"GB West","year":"2003","unstructured":"West, G. B. et al. Why does metabolic rate scale with body size? Physiology (communication arising). Nature 421, 713\u2013713 (2003).","journal-title":"Nature"},{"key":"92087_CR15","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1136\/sextrans-2014-051932","volume":"91","author":"O Patterson-Lomba","year":"2015","unstructured":"Patterson-Lomba, O., Goldstein, E., G\u00f3mez-Li\u00e9vano, A., Castillo-Chavez, C. & Towers, S. Per capita incidence of sexually transmitted infections increases systematically with urban population size: a cross-sectional study. Sex. Transm. Infect. 91, 610\u2013614 (2015).","journal-title":"Sex. Transm Infect."},{"key":"92087_CR16","doi-asserted-by":"publisher","first-page":"eabl6325","DOI":"10.1126\/sciadv.abl6325","volume":"7","author":"U Bilal","year":"2021","unstructured":"Bilal, U. et al. Scaling of mortality in 742 metropolitan areas of the Americas. Sci. Adv. 7, eabl6325 (2021).","journal-title":"Sci. Adv."},{"key":"92087_CR17","unstructured":"United Nations. The World\u2019s Cities in 2016\u2014Data Booklet (eds P.D. Department of Economic and Social Affairs) (United Nations, 2016)."},{"key":"92087_CR18","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/s41591-020-01214-4","volume":"27","author":"U Bilal","year":"2021","unstructured":"Bilal, U. et al. Life expectancy and mortality in 363 cities of Latin America. Nat. Med. 27, 463\u2013470 (2021).","journal-title":"Nat. Med."},{"key":"92087_CR19","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1136\/tc.11.4.305","volume":"11","author":"J Barnoya","year":"2002","unstructured":"Barnoya, J. Tobacco industry success in preventing regulation of secondhand smoke in Latin America: the \u2018Latin project\u2019. Tob. Control 11, 305\u2013314 (2002).","journal-title":"Tob. Control"},{"key":"92087_CR20","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1080\/17441692.2017.1316414","volume":"13","author":"A Arredondo","year":"2018","unstructured":"Arredondo, A., Azar, A. & Recam\u00e1n, A. L. Diabetes, a global public health challenge with a high epidemiological and economic burden on health systems in Latin America. Glob. Public Health 13, 780\u2013787 (2018).","journal-title":"Glob. Public Health"},{"key":"92087_CR21","doi-asserted-by":"publisher","first-page":"5142","DOI":"10.1017\/S1368980021001403","volume":"24","author":"C Palacios","year":"2021","unstructured":"Palacios, C. et al. Obesity in Latin America, a scoping review of public health prevention strategies and an overview of their impact on obesity prevention. Public Health Nutr. 24, 5142\u20135155 (2021).","journal-title":"Public Health Nutr."},{"key":"92087_CR22","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s11524-015-9976-x","volume":"92","author":"LEC Rocha","year":"2015","unstructured":"Rocha, L. E. C., Thorson, A. E. & Lambiotte, R. The non-linear health consequences of living in larger cities. J. Urban Health 92, 785\u2013799 (2015).","journal-title":"J. Urban Health"},{"key":"92087_CR23","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1161\/CIRCULATIONAHA.104.521708","volume":"112","author":"M Ezzati","year":"2005","unstructured":"Ezzati, M., Henley, S. J., Thun, M. J. & Lopez, A. D. Role of smoking in global and regional cardiovascular mortality. Circulation 112, 489\u2013497 (2005).","journal-title":"Circulation"},{"key":"92087_CR24","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.healthplace.2006.11.001","volume":"13","author":"B Idris","year":"2007","unstructured":"Idris, B. et al. Higher smoking prevalence in urban compared to non-urban areas: time trends in six European countries. Health Place 13, 702\u2013712 (2007).","journal-title":"Health Place"},{"key":"92087_CR25","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12942-017-0092-x","volume":"16","author":"T Yang","year":"2017","unstructured":"Yang, T. et al. Contextual influences affecting patterns of overweight and obesity among university students: a 50 universities population-based study in China. Int. J. Health Geogr. 16, 18 (2017).","journal-title":"Int. J. Health Geogr."},{"key":"92087_CR26","doi-asserted-by":"publisher","unstructured":"Balandr\u00e1n, A. et al. Health Systems in Transition: Mexico. https:\/\/doi.org\/10.3138\/9781487538422 (University of Toronto, 2021).","DOI":"10.3138\/9781487538422"},{"key":"92087_CR27","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1590\/S0104-12902013000200013","volume":"22","author":"MA Separavich","year":"2013","unstructured":"Separavich, M. A. & Canesqui, A. M. Sa\u00fade do homem e masculinidades Na pol\u00edtica Nacional de Aten\u00e7\u00e3o integral \u00e0 Sa\u00fade do Homem: uma Revis\u00e3o bibliogr\u00e1fica. Saude Soc. 22, 415\u2013428 (2013).","journal-title":"Saude Soc."},{"key":"92087_CR28","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1590\/S0102-311X2007000300015","volume":"23","author":"R Gomes","year":"2007","unstructured":"Gomes, R., Nascimento, E. F. D. & Ara\u00fajo, F. C. D. Por Que Os homens Buscam Menos Os servi\u00e7os de Sa\u00fade do Que as mulheres? As explica\u00e7\u00f5es de homens com Baixa escolaridade e homens com Ensino superior. Cad Saude Publica. 23, 565\u2013574 (2007).","journal-title":"Cad Saude Publica"},{"key":"92087_CR29","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1177\/0898264314527477","volume":"26","author":"LS Rohlfsen","year":"2014","unstructured":"Rohlfsen, L. S. & Jacobs Kronenfeld, J. Gender differences in trajectories of self-rated health in middle and old age: an examination of differential exposure and differential vulnerability. J. Aging Health. 26, 637\u2013662 (2014).","journal-title":"J. Aging Health"},{"key":"92087_CR30","unstructured":"UN Women. Progress of the World\u2019s Women 2015\u20132016: Transforming Economies, Realizing Rights 342 (2015)."},{"key":"92087_CR31","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1186\/s12889-022-13752-2","volume":"22","author":"M Castillo-Riquelme","year":"2022","unstructured":"Castillo-Riquelme, M. et al. Aging and self-reported health in 114 Latin American cities: gender and socio-economic inequalities. BMC Public Health. 22, 1499 (2022).","journal-title":"BMC Public Health"},{"key":"92087_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/409083","volume":"2013","author":"V Mohan","year":"2013","unstructured":"Mohan, V., Seedat, Y. K. & Pradeepa, R. The rising burden of diabetes and hypertension in Southeast Asian and African regions: need for effective strategies for prevention and control in primary health care settings. Int. J. Hypertens. 2013, 1\u201314 (2013).","journal-title":"Int. J. Hypertens."},{"key":"92087_CR33","doi-asserted-by":"publisher","first-page":"e55149","DOI":"10.1590\/1980-0037.2019v21e55149","volume":"21","author":"EZ Martinez","year":"2019","unstructured":"Martinez, E. Z. et al. Association between diabetes, hypertension, activities of daily living and physical activity among elderly users of primary healthcare facilities. Rev. Bras. Cineantropom Desempenho Hum. 21, e55149 (2019).","journal-title":"Rev. Bras. Cineantropom Desempenho Hum."},{"key":"92087_CR34","doi-asserted-by":"publisher","first-page":"264","DOI":"10.17843\/rpmesp.2023.403.13284","volume":"1","author":"A Alcaraz","year":"2023","unstructured":"Alcaraz, A. & Pichon-Riviere, A. El control Del Tabaco En Am\u00e9rica Latina: Logros, pendientes y Nuevos desaf\u00edos. Rev. Peru Med. Exp. Salud Publica 1, 264\u2013266. https:\/\/doi.org\/10.17843\/rpmesp.2023.403.13284 (2023).","journal-title":"Rev. Peru Med. Exp. Salud Publica"},{"key":"92087_CR35","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0140-6736(19)31243-7","volume":"394","author":"MC Castro","year":"2019","unstructured":"Castro, M. C. et al. Brazil\u2019s unified health system: the first 30 years and prospects for the future. Lancet 394, 345\u2013356 (2019).","journal-title":"Lancet"},{"key":"92087_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/0102-311x00113016","volume":"33","author":"MJ Marro","year":"2017","unstructured":"Marro, M. J., Cardoso, A. M. & Leite, I. D. C. Desigualdades regionales En La Mortalidad Por diabetes mellitus y En El acceso a La Salud En Argentina. Cad Sa\u00fade P\u00fabl. 33, 1 (2017).","journal-title":"Cad Sa\u00fade P\u00fabl."},{"key":"92087_CR37","doi-asserted-by":"publisher","first-page":"57","DOI":"10.37757\/MR2017.V19.N2-3.10","volume":"19","author":"A Castillo-Laborde","year":"2017","unstructured":"Castillo-Laborde, A. et al. Health insurance scheme performance and effects on health and health inequalities in Chile. MEDICC Rev. 19, 57\u201364 (2017).","journal-title":"MEDICC Rev."},{"key":"92087_CR38","first-page":"100148","volume":"7","author":"RM Carrillo-Larco","year":"2022","unstructured":"Carrillo-Larco, R. M. et al. Peru\u2014Progress in health and sciences in 200 years of independence. Lancet Reg. Health Am. 7, 100148 (2022).","journal-title":"Lancet Reg. Health Am."},{"key":"92087_CR39","doi-asserted-by":"publisher","first-page":"737","DOI":"10.7705\/biomedica.4453","volume":"39","author":"L Hilari\u00f3n-Gait\u00e1n","year":"2019","unstructured":"Hilari\u00f3n-Gait\u00e1n, L., D\u00edaz-Jim\u00e9nez, D. & Cotes-Cantillo, K. Casta\u00f1eda-Orjuela, C. Desigualdades En Salud Seg\u00fan r\u00e9gimen de afiliaci\u00f3n y eventos notificados al sistema de vigilancia (Sivigila) En Colombia, 2015. Biomedica 39, 737\u2013747 (2019).","journal-title":"Biomedica"},{"key":"92087_CR40","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1111\/j.1468-0009.2005.00398.x","volume":"83","author":"AR Omran","year":"2005","unstructured":"Omran, A. R. The epidemiologic transition: A theory of the epidemiology of population change. Milbank Q. 83, 731\u2013757 (2005).","journal-title":"Milbank Q."},{"key":"92087_CR41","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.compenvurbsys.2016.04.006","volume":"63","author":"C Cottineau","year":"2017","unstructured":"Cottineau, C., Hatna, E., Arcaute, E. & Batty, M. Diverse cities or the systematic paradox of urban scaling laws. Comput. Environ. Urban Syst. 63, 80\u201394 (2017).","journal-title":"Comput. Environ. Urban Syst."},{"key":"92087_CR42","doi-asserted-by":"crossref","unstructured":"Portugali, J. et al. Complexity Theories of Cities Have Come of Age: An Overview with Implications to Urban Planning and Design 449 (Springer, 2012).","DOI":"10.1007\/978-3-642-24544-2"},{"key":"92087_CR43","doi-asserted-by":"publisher","first-page":"13759","DOI":"10.1073\/pnas.1906258116","volume":"116","author":"M Keuschnigg","year":"2019","unstructured":"Keuschnigg, M. Scaling trajectories of cities. Proc. Natl. Acad. Sci. U.S.A. 116, 13759\u201313761 (2019).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"92087_CR44","doi-asserted-by":"publisher","first-page":"20150937","DOI":"10.1098\/rsif.2015.0937","volume":"13","author":"H Youn","year":"2016","unstructured":"Youn, H. et al. Scaling and universality in urban economic diversification. J. R. Soc. Interface 13, 20150937 (2016).","journal-title":"J. R. Soc. Interface"},{"key":"92087_CR45","doi-asserted-by":"publisher","first-page":"20190846","DOI":"10.1098\/rsif.2019.0846","volume":"17","author":"LMA Bettencourt","year":"2020","unstructured":"Bettencourt, L. M. A. et al. The interpretation of urban scaling analysis in time. J. R. Soc. Interface 17, 20190846 (2020).","journal-title":"J. R. Soc. Interface"},{"key":"92087_CR46","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/467912a","volume":"467","author":"L Bettencourt","year":"2010","unstructured":"Bettencourt, L. & West, G. A unified theory of urban living. Nature 467, 912\u2013913 (2010).","journal-title":"Nature"},{"key":"92087_CR47","doi-asserted-by":"crossref","unstructured":"Bettencourt, L. M. A., Lobo, J., Helbing, D., K\u00fchnert, C. & West, G. B. Growth, innovation, scaling, and the pace of life in cities. Proc. Natl. Acad. Sci. U.S.A. 104, 7301\u20137306 (2007).","DOI":"10.1073\/pnas.0610172104"},{"key":"92087_CR48","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s11524-018-00326-0","volume":"96","author":"DA Quistberg","year":"2019","unstructured":"Quistberg, D. A. et al. Building a data platform for cross-country urban health studies: the SALURBAL study. J. Urban Health 96, 311\u2013337 (2019).","journal-title":"J. Urban Health"},{"key":"92087_CR49","doi-asserted-by":"publisher","first-page":"1800013","DOI":"10.1002\/gch2.201800013","volume":"3","author":"AV Diez Roux","year":"2019","unstructured":"Diez Roux, A. V. et al. A novel international partnership for actionable evidence on urban health in Latin America: LAC-urban health and SALURBAL. Global Challenges 3, 1800013 (2019).","journal-title":"Global Challenges"},{"key":"92087_CR50","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1136\/jech-2020-216116","volume":"75","author":"A Braverman-Bronstein","year":"2021","unstructured":"Braverman-Bronstein, A. et al. Association of education level with diabetes prevalence in Latin American cities and its modification by City social environment. J. Epidemiol. Community Health 75, 874\u2013880 (2021).","journal-title":"J. Epidemiol. Community Health"},{"key":"92087_CR51","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1017\/S1368980021002457","volume":"25","author":"M Mazariegos","year":"2022","unstructured":"Mazariegos, M. et al. Educational inequalities in obesity: a multilevel analysis of survey data from cities in Latin America. Public Health Nutr. 25, 1790\u20131798 (2022).","journal-title":"Public Health Nutr."},{"key":"92087_CR52","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/EDE.0000000000001118","volume":"31","author":"H Quick","year":"2020","unstructured":"Quick, H., Terloyeva, D., Wu, Y., Moore, K. & Diez Roux, A. V. Trends in tract-level prevalence of obesity in Philadelphia by race-ethnicity, space, and time. Epidemiology 31, 15\u201321 (2020).","journal-title":"Epidemiology"}],"container-title":["Scientific Reports"],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92087-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92087-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92087-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T09:19:13Z","timestamp":1740820753000},"score":9.728826,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92087-5"}},"issued":{"date-parts":[[2025,3,1]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["92087"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-92087-5","ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"published":{"date-parts":[[2025,3,1]]},"assertion":[{"value":"3 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The SALURBAL study protocol was approved by the Drexel University Institutional Review Board with ID #1612005035 and by appropriate site-specific IRBs.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"7279"}],"items-per-page":20,"query":{"start-index":0,"search-terms":null}}}